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https://www.readbyqxmd.com/read/29163351/computed-tomography-perfusion-alberta-stroke-program-early-computed-tomography-score-is-associated-with-hemorrhagic-transformation-after-acute-cardioembolic-stroke
#1
Lan Liu, Bo Wu, Jinglong Zhao, Yanyan Cao, Nikita Dedhia, Louis R Caplan, Qiaoshu Wang
Alberta Stroke Program Early Computed Tomography (CT) score (ASPECTS) has been applied to CT perfusion (CTP) with good interrater agreement to predict early ischemic stroke, and it can be useful in decision making in acute ischemic stroke. The aim of the present study was to assess the predictive value of CTP ASPECTS of hemorrhagic transformation (HT) in acute cardioembolic stroke. This is a single-enter, retrospective study. All patients hospitalized with acute cardioembolic stroke from January 2008 to September 2013 were included...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29162523/specific-visualization-of-neuromelanin-iron-complex-and-ferric-iron-in-the-human-post-mortem-substantia-nigra-using-mr-relaxometry-at-7t
#2
Hansol Lee, Sun-Yong Baek, Se Young Chun, Jae-Hyeok Lee, HyungJoon Cho
Neuromelanin (NM) is an endogenous iron chelating molecule of pigmented neurons in the human substantia nigra (SN). Along with the increase in iron deposition, the reduction in NM-containing dopaminergic neurons and the variation of iron load on NM are generally considered to be important factors participating to pathogenesis of Parkinson's disease (PD). The aim of this study was to non-invasively delineate the spatial distributions of paramagnetic magnetic susceptibility perturbers, such as NM-iron complex and ferric iron in SN...
November 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/29159960/mapping-the-structural-and-functional-network-architecture-of-the-medial-temporal-lobe-using-7t-mri
#3
Preya Shah, Danielle S Bassett, Laura E M Wisse, John A Detre, Joel M Stein, Paul A Yushkevich, Russell T Shinohara, John B Pluta, Elijah Valenciano, Molly Daffner, David A Wolk, Mark A Elliott, Brian Litt, Kathryn A Davis, Sandhitsu R Das
Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla...
November 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29159883/phase-sensitive-b1-mapping-effects-of-relaxation-and-rf-spoiling
#4
Jie Wen, Alexander L Sukstanskii, Dmitriy A Yablonskiy
PURPOSE: To develop a phase-based B1 mapping technique accounting for the effects of imperfect RF spoiling and magnetization relaxation. THEORY AND METHODS: The technique is based on a multi-gradient-echo sequence with 2 successive orthogonal radiofrequency (RF) excitation pulses followed by the train of gradient echoes measurements. We have derived a theoretical expression relating the MR signal phase produced by the 2 successive RF pulses to the B1 field and B0 -related frequency shift...
November 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29157260/high-resolution-and-accelerated-multi-parametric-mapping-with-automated-characterization-of-vessel-disease-using-intravascular-mri
#5
Guan Wang, Yi Zhang, Shashank Sathyanarayana Hegde, Paul A Bottomley
BACKGROUND: Atherosclerosis is prevalent in cardiovascular disease, but present imaging modalities have limited capabilities for characterizing lesion stage, progression and response to intervention. This study tests whether intravascular magnetic resonance imaging (IVMRI) measures of relaxation times (T1, T2) and proton density (PD) in a clinical 3 Tesla scanner could characterize vessel disease, and evaluates a practical strategy for accelerated quantification. METHODS: IVMRI was performed in fresh human artery segments and swine vessels in vivo, using fast multi-parametric sequences, 1-2 mm diameter loopless antennae and 200-300 μm resolution...
November 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29153711/characterisation-of-heterogeneity-and-spatial-autocorrelation-in-phase-separating-mixtures-using-moran-s-i
#6
Emma S Thompson, Pieter Saveyn, Marc Declercq, Joris Meert, Vincenzo Guida, Charles D Eads, Eric S J Robles, Melanie M Britton
In complex colloidal systems, particle-poor regions can develop within particle-rich phases during sedimentation or creaming. These particle-poor regions are overlooked by 1D profiles, which are typically used to assess particle distributions in a sample. Alternative methods to visualise and quantify these regions are required to better understand phase separation, which is the focus of this paper. Magnetic resonance imaging has been used to monitor the development of compositional heterogeneity in a vesicle-polymer mixture undergoing creaming...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153657/cardiac-magnetic-resonance-imaging-in-myocardial-inflammation-in-autoimmune-rheumatic-diseases-an-appraisal-of-the-diagnostic-strengths-and-limitations-of-the-lake-louise-criteria
#7
Sophie Mavrogeni, Juerg Schwitter, Albert van Rossum, Robin Nijveldt, Antony Aletras, Genovefa Kolovou, Gerald Pohost, Joao Lima
Myocardial inflammation in autoimmune rheumatic diseases (ARDs) is the endpoint of various pathophysiologic processes. The Lake Louise-criteria is the most popular approach for the diagnosis of myocarditis. However, due to the diversity of myocardial inflammation in ARDs, some issues should be acknowledged. Of the three Lake Louise indices, early and late gadolinium enhancement (EGE and LGE respectively) measurements may be affected by co-existing disease processes or be present due to a fibrotic ARD like systemic sclerosis, leaving T2-ratio as the only uniformly robust measurement across ARDs...
November 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29153575/persistent-iron-within-the-infarct-core%C3%A2-after-st-segment-elevation-myocardial-infarction-implications-for-left-ventricular-remodeling-and-health%C3%A2-outcomes
#8
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
OBJECTIVES: This study sought to determine the incidence and prognostic significance of persistent iron in patients post-ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The clinical significance of persistent iron within the infarct core after STEMI complicated by acute myocardial hemorrhage is poorly understood. METHODS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction])...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29153506/role-of-non-local-interactions-between-cdr-loops-in-binding-affinity-of-mr78-antibody-to-marburg-virus-glycoprotein
#9
Amandeep K Sangha, Jinhui Dong, Lauren Williamson, Takao Hashiguchi, Erica Ollmann Saphire, James E Crowe, Jens Meiler
An atomic-detail model of the Marburg virus glycoprotein in complex with a neutralizing human monoclonal antibody designated MR78 was constructed using Phenix.Rosetta starting from a 3.6Å crystallographic density map. The Asp at T6 in the HCDR3's bulged torso cannot form the canonical salt bridge as position T2 lacks an Arg or Lys residue. It instead engages in a hydrogen bond interaction with a Tyr contributed by the HCDR1 loop. This inter-CDR loop interaction stabilizes the bulged conformation needed for binding to the viral glycoprotein: a Tyr to Phe mutant displays a binding affinity reduced by a factor of at least 10...
November 14, 2017: Structure
https://www.readbyqxmd.com/read/29152942/effects-of-positive-end-expiratory-pressure-on-intracranial-pressure-during-pneumoperitoneum-and-trendelenburg-position-in-a-porcine-mode
#10
Nurdan Bedirli, Gökçen Emmez, Yusuf Ünal, Mehmet Tönge, Hakan Emmez
Background/aim: This study was undertaken to evaluate the effects of positive end-expiratory pressure (PEEP) levels on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) and to determine the appropriate PEEP level during steep Trendelenburg position combined with pneumoperitoneum.Materials and methods: Ten pigs were included in this study. Pneumoperitoneum and Trendelenburg position were maintained and PEEP titration was initiated. Arterial pressure, heart rate, arterial blood gas, ICP, and CPP were recorded at the following time points: baseline (T0), 30 min after positioning and pneumoperitoneum (T1), PEEP 5 (T2), PEEP 10 (T3), PEEP 15 (T4), and PEEP 20 (T5)...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152563/integrated-radiomic-framework-for-breast-cancer-and-tumor-biology-using-advanced-machine-learning-and-multiparametric-mri
#11
Vishwa S Parekh, Michael A Jacobs
Radiomics deals with the high throughput extraction of quantitative textural information from radiological images that not visually perceivable by radiologists. However, the biological correlation between radiomic features and different tissues of interest has not been established. To that end, we present the radiomic feature mapping framework to generate radiomic MRI texture image representations called the radiomic feature maps (RFM) and correlate the RFMs with quantitative texture values, breast tissue biology using quantitative MRI and classify benign from malignant tumors...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29151166/t2-weighted-images-are-superior-to-other-mr-image-types-for-the-determination-of-diffuse-intrinsic-pontine-glioma-intratumoral-heterogeneity
#12
Stephen Harward, S Harrison Farber, Michael Malinzak, Oren Becher, Eric M Thompson
PURPOSE: Diffuse intrinsic pontine glioma (DIPG) remains the main cause of death in children with brain tumors. Given the inefficacy of numerous peripherally delivered agents to treat DIPG, convection enhanced delivery (CED) of therapeutic agents is a promising treatment modality. The purpose of this study was to determine which MR imaging type provides the best discrimination of intratumoral heterogeneity to guide future stereotactic implantation of CED catheters into the most cellular tumor regions...
November 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149177/new-brain-lesions-with-no-impact-on-physical-disability-can-impact-cognition-in-early-multiple-sclerosis-a-ten-year-longitudinal-study
#13
D Wybrecht, F Reuter, F Pariollaud, W Zaaraoui, A Le Troter, A Rico, S Confort-Gouny, E Soulier, M Guye, A Maarouf, J-P Ranjeva, J Pelletier, B Audoin
OBJECTIVE: In early multiple sclerosis, although brain T2 lesions accrual are hallmark of the disease, only weak correlations were found between T2 lesions accrual and EDSS progression, the disability scale commonly used in multiple sclerosis studies. This may be related to the very poor sensitivity of EDSS to cognitive dysfunctions that may occur and progress from the first stage of the disease. In the present study, we aimed to demonstrate that cognitive deficits progress during the first ten years of MS and are significantly impacted by new T2 lesions...
2017: PloS One
https://www.readbyqxmd.com/read/29146220/autologous-chondrocyte-implantation-for-talar-osteochondral-lesions-comparison-between-5-year-follow-up-magnetic-resonance-imaging-findings-and-7-year-follow-up-clinical-results
#14
Gherardo Pagliazzi, Francesca Vannini, Milva Battaglia, Laura Ramponi, Roberto Buda
Autologous chondrocyte implantation (ACI) is an established surgical procedure that has provided satisfactory results. The aim of the present study was to correlate the clinical outcomes of a series of 20 patients treated by ACI at a 7-year follow-up examination with the magnetic resonance imaging (MRI) T2-mapping 5-year follow-up findings. We evaluated 20 patients using the American Orthopaedic Foot and Ankle Society (AOFAS) score preoperatively and the established follow-up protocol until 87.2 ± 14.5 months...
November 14, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29136120/t2-mapping-cardiovascular-magnetic-resonance-identifies-the-presence-of-myocardial-inflammation-in-patients-with-dilated-cardiomyopathy-as-compared-to-endomyocardial-biopsy
#15
M Spieker, E Katsianos, M Gastl, P Behm, P Horn, C Jacoby, B Schnackenburg, P Reinecke, M Kelm, R Westenfeld, F Bönner
Aims: The aim of this study was to determine the value of T2 mapping for the non-invasive assessment of myocardial inflammation in different stages of systolic left ventricular dysfunction in dilated cardiomyopathy (DCM) in comparison with endomyocardial biopsy (EMB). Methods and results: A total of 132 subjects were enrolled between 2013 and 2016 (62 controls and 70 patients with DCM). All patients underwent CMR at 1.5 T and received coronary angiogram and EMB...
November 10, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29136015/the-influences-of-walking-running-and-stair-activity-on-knee-articular-cartilage-quantitative-mri-using-t1-rho-and-t2-mapping
#16
Meng Chen, Lin Qiu, Si Shen, Fei Wang, Jing Zhang, Cici Zhang, Sirun Liu
OBJECTIVE: To explore the different influences of walking, running and stair activity on knee articular cartilage with T1 rho and T2 mapping sequences. MATERIALS AND METHODS: MRI (3.0-T) scans of the right knee were performed in twenty-three young healthy adults immediately after 30 minutes of rest, walking, running and stair activity respectively. Articular cartilage was quantitatively assessed based on T1 rho and T2 relaxation times. Analysis of variance for random block design data, bonferroni test and paired samples t tests were performed to estimate the different influences of physiological activities on articular cartilage...
2017: PloS One
https://www.readbyqxmd.com/read/29126367/t2-mapping-of-acetabular-cartilage-in-patients-with-femoroacetabular-impingement-at-3-tesla-comparative-analysis-with-arthroscopic-findings
#17
Tobias Hesper, Christina Neugroda, Christoph Schleich, Gerald Antoch, Harish Hosalkar, Rüdiger Krauspe, Christoph Zilkens, Bernd Bittersohl
Objective To evaluate the diagnostic accuracy of T2*-mapping for detecting acetabular cartilage damage in patients with symptomatic femoroacetabular impingement (FAI). Design A total of 29 patients (17 females, 12 males, mean age 35.6 ± 12.8 years, mean body mass index 25.1 ± 4.1 kg/m(2), 16 right hips) with symptomatic FAI underwent T2* MRI and subsequent hip arthroscopy. T2* values were obtained by region of interest analysis in seven radially reformatted planes around the femoral neck (anterior, anterior-superior, superior-anterior, superior, superior-posterior, posterior-superior, posterior)...
November 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29123919/t2-mapping-and-post-contrast-t1-dgemric-of-the-patellar-cartilage-12-year-follow-up-after-patellar-stabilizing-surgery-in-childhood
#18
Eva Bengtsson Moström, Eveliina Lammentausta, Thröstur Finnbogason, Lars Weidenhielm, Per-Mats Janarv, Carl Johan Tiderius
Background: Cartilage degeneration has been reported after recurrent patellar dislocation. However, effects of surgical stabilization in childhood have not yet been described. Purpose: To examine the cartilage quality in very young adults operated with a patellar stabilizing procedure due to recurrent patellar dislocation in childhood, and evaluate if cartilage quality correlates with clinical parameters and patient-reported outcomes. Material and Methods: Seventeen patients were investigated ≥ 5 years (mean = 11...
October 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/29122471/3d-registration-of-mpmri-for-assessment-of-prostate-cancer-focal-therapy
#19
Clément Orczyk, Andrew B Rosenkrantz, Artem Mikheev, Arnauld Villers, Myriam Bernaudin, Samir S Taneja, Samuel Valable, Henry Rusinek
RATIONALE AND OBJECTIVES: This study aimed to assess a novel method of three-dimensional (3D) co-registration of prostate magnetic resonance imaging (MRI) examinations performed before and after prostate cancer focal therapy. MATERIALS AND METHODS: We developed a software platform for automatic 3D deformable co-registration of prostate MRI at different time points and applied this method to 10 patients who underwent focal ablative therapy. MRI examinations were performed preoperatively, as well as 1 week and 6 months post treatment...
November 6, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29121971/cmr-based-blood-oximetry-via-multi-parametric-estimation-using-multiple-t2-measurements
#20
Juliet Varghese, Lee C Potter, Richard LaFountain, Xueliang Pan, Subha V Raman, Rizwan Ahmad, Orlando P Simonetti
BACKGROUND: Measurement of blood oxygen saturation (O2 saturation) is of great importance for evaluation of patients with many cardiovascular diseases, but currently there are no established non-invasive methods to measure blood O2 saturation in the heart. While T2-based CMR oximetry methods have been previously described, these approaches rely on technique-specific calibration factors that may not generalize across patient populations and are impractical to obtain in individual patients...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
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