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Cmr and valve

Franck Levy, Laura Iacuzio, Filippo Civaia, Stephane Rusek, Carine Dommerc, Nicolas Hugues, Clara Alexandrescu, Vincent Dor, Christophe Tribouilloy, Gilles Dreyfus
BACKGROUND: Recently, 1.5-Tesla cardiac magnetic resonance imaging (CMR) was reported to provide a reliable alternative to transthoracic echocardiography (TTE) for the quantification of aortic stenosis (AS) severity. Few data are available using higher magnetic field strength MRI systems in this context. AIMS: To evaluate the feasibility and reproducibility of the assessment of aortic valve area (AVA) using 3-Tesla CMR in routine clinical practice, and to assess concordance between TTE and CMR for the estimation of AS severity...
September 28, 2016: Archives of Cardiovascular Diseases
Raluca G Chelu, Kevin W Wanambiro, Albert Hsiao, Laurens E Swart, Teun Voogd, Allard T van den Hoven, Matthijs van Kranenburg, Adriaan Coenen, Sara Boccalini, Piotr A Wielopolski, Mika W Vogel, Gabriel P Krestin, Shreyas S Vasanawala, Ricardo P J Budde, Jolien W Roos-Hesselink, Koen Nieman
OBJECTIVES: In this study, we evaluated a cloud-based platform for cardiac magnetic resonance (CMR) four-dimensional (4D) flow imaging, with fully integrated correction for eddy currents, Maxwell phase effects, and gradient field non-linearity, to quantify forward flow, regurgitation, and peak systolic velocity over the pulmonary artery. METHODS: We prospectively recruited 52 adult patients during one-year period from July 2014. The 4D flow and planar (2D) phase-contrast (PC) were acquired during same scanning session, but 4D flow was scanned after injection of a gadolinium-based contrast agent...
October 2016: European Journal of Radiology
Dalin Tang, Pedro J Del Nido, Chun Yang, Heng Zuo, Xueying Huang, Rahul H Rathod, Vasu Gooty, Alexander Tang, Zheyang Wu, Kristen L Billiar, Tal Geva
BACKGROUND: Accurate calculation of ventricular stress and strain is critical for cardiovascular investigations. Sarcomere shortening in active contraction leads to change of ventricular zero-stress configurations during the cardiac cycle. A new model using different zero-load diastole and systole geometries was introduced to provide more accurate cardiac stress/strain calculations with potential to predict post pulmonary valve replacement (PVR) surgical outcome. METHODS: Cardiac magnetic resonance (CMR) data were obtained from 16 patients with repaired tetralogy of Fallot prior to and 6 months after pulmonary valve replacement (8 male, 8 female, mean age 34...
2016: PloS One
Chee Loong Chow, Sylvia S M Chen, William van Gaal
CLINICAL INTRODUCTION: A 66-year-old asymptomatic patient underwent a routine transthoracic echocardiogram prior to commencement of clozapine, and was found to have a mobile echogenic structure in the right atrium, which was later confirmed on transoesophageal echocardiogram to be adjacent to the insertion of inferior vena cava.Follow-up cardiovascular MRI (CMR) revealed a mobile, avascular 2.1×2.2 cm(2) mass with regular and smooth borders, adjacent to the eustachian valve (Figure 1 panel A: coronal view; online supplementary movie 1)...
September 12, 2016: Heart: Official Journal of the British Cardiac Society
Litten Bertelsen, Jesper Hastrup Svendsen, Lars Køber, Ketil Haugan, Søren Højberg, Carsten Thomsen, Niels Vejlstrup
BACKGROUND: Cardiovascular magnetic resonance (CMR) is considered the gold standard of cardiac volumetric measurements. Flow in the aortic root is often measured at the sinotubular junction, even though placing the slice just above valve level may be more precise. It is unknown how much flow measurements vary at different levels in the aortic root and which level corresponds best to left ventricle volumetry. METHODS: All patients were older than 70 years presenting with at least one of the following diagnoses: diabetes, hypertension, prior stroke and/or heart failure...
September 7, 2016: Journal of Cardiovascular Magnetic Resonance
Tarique Al Musa, Akhlaque Uddin, Timothy A Fairbairn, Laura E Dobson, Christopher D Steadman, Ananth Kidambi, David P Ripley, Peter P Swoboda, Adam K McDiarmid, Bara Erhayiem, Pankaj Garg, Daniel J Blackman, Sven Plein, Gerald P McCann, John P Greenwood
OBJECTIVE: The response of the RV following treatment of aortic stenosis is poorly defined, reflecting the challenge of accurate RV assessment. Cardiovascular magnetic resonance (CMR) is the established reference for imaging of RV volumes, mass and function. We sought to define the impact of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) upon RV function in patients treated for severe aortic stenosis using CMR. METHODS: A 1...
November 15, 2016: International Journal of Cardiology
An H Bui, Sébastien Roujol, Murilo Foppa, Kraig V Kissinger, Beth Goddu, Thomas H Hauser, Peter J Zimetbaum, Long H Ngo, Warren J Manning, Reza Nezafat, Francesca N Delling
OBJECTIVE: We aimed to investigate the association of diffuse myocardial fibrosis by cardiac magnetic resonance (CMR) T1 with complex ventricular arrhythmia (ComVA) in mitral valve prolapse (MVP). METHODS: A retrospective analysis was performed on 41 consecutive patients with MVP referred for CMR between 2006 and 2011, and 31 healthy controls. Arrhythmia analysis was available in 23 patients with MVP with Holter/event monitors. Left ventricular (LV) septal T1 times were derived from Look-Locker sequences after administration of 0...
August 11, 2016: Heart: Official Journal of the British Cardiac Society
Xi Liu, Qin Zhang, Zhi-Gang Yang, Ying-Kun Guo, Ke Shi, Hua-Yan Xu, Ling-Yi Wen, Rui Li, Jing Chen
PURPOSE: The aim of this study was to assess the correlations of functional and dimensional parameters with the severity of tricuspid regurgitation in patients with Ebstein's anomaly (EA) by using cardiac magnetic resonance (CMR) imaging. MATERIALS AND METHODS: Thirty-three patients with EA without previous cardiac surgery and 25 normal individuals were recruited and underwent both cardiac MR imaging and preoperative transthoracic echocardiography. The left ventricular (LV) functional parameters and dimensions of the right ventricle (RV) and LV were measured using 3...
September 2016: European Journal of Radiology
Henrique B Ribeiro, Stefan Orwat, Salim S Hayek, Éric Larose, Vasilis Babaliaros, Abdellaziz Dahou, Florent Le Ven, Sergio Pasian, Rishi Puri, Omar Abdul-Jawad Altisent, Francisco Campelo-Parada, Marie-Annick Clavel, Philippe Pibarot, Stamatios Lerakis, Helmut Baumgartner, Josep Rodés-Cabau
BACKGROUND: Residual aortic regurgitation (AR) following transcatheter aortic valve replacement (TAVR) is associated with greater mortality; yet, determining AR severity post-TAVR using Doppler echocardiography remains challenging. Cardiovascular magnetic resonance (CMR) is purported as a more accurate means of quantifying AR; however, no data exist regarding the prognostic value of AR as assessed by CMR post-TAVR. OBJECTIVES: This study sought to evaluate the effect of AR assessed with CMR on clinical outcomes post-TAVR...
August 9, 2016: Journal of the American College of Cardiology
Jonathan Nadjiri, Hanna Nieberler, Eva Hendrich, Albrecht Will, Costanza Pellegrini, Oliver Husser, Christian Hengstenberg, Andreas Greiser, Stefan Martinoff, Martin Hadamitzky
The benefit of a transcatheter aortic valve replacement (TAVR) can differ in patients, and therapy bears severe risks. High-degree aortic stenosis can lead to cardiac damage such as diffuse myocardial fibrosis, evaluable by extra-cellular volume (ECV) in CMR. Therefore, fibrosis might be a possible risk factor for unfavorable outcome after TAVR. We sought to assess the prognostic value of T1-mapping and ECV to predict adverse events during and after TAVR. The study population consisted of patients undergoing clinically indicated TAVR by performing additional CMR with native and contrast-enhanced T1-mapping sequences for additional evaluation of ECV...
November 2016: International Journal of Cardiovascular Imaging
Tarique Al Musa, Sven Plein, John P Greenwood
Degenerative aortic stenosis (AS) is the most common valvular disease in the western world with a prevalence expected to double within the next 50 years. International guidelines advocate the use of cardiovascular magnetic resonance (CMR) as an investigative tool, both to guide diagnosis and to direct optimal treatment. CMR is the reference standard for quantifying both left and right ventricular volumes and mass, which is essential to assess the impact of AS upon global cardiac function. Given the ability to image any structure in any plane, CMR offers many other diagnostic strengths including full visualisation of valvular morphology, direct planimetry of orifice area, the quantification of stenotic jets and in particular, accurate quantification of valvular regurgitation...
June 2016: Quantitative Imaging in Medicine and Surgery
Alistair C Lindsay, Katie Harron, Richard J Jabbour, Ritesh Kanyal, Thomas M Snow, Paramvir Sawhney, Francisco Alpendurada, Michael Roughton, Dudley J Pennell, Alison Duncan, Carlo Di Mario, Simon W Davies, Raad H Mohiaddin, Neil E Moat
BACKGROUND: Cardiovascular magnetic resonance (CMR) can provide important structural information in patients undergoing transcatheter aortic valve implantation. Although CMR is considered the standard of reference for measuring ventricular volumes and mass, the relationship between CMR findings of right ventricular (RV) function and outcomes after transcatheter aortic valve implantation has not previously been reported. METHODS AND RESULTS: A total of 190 patients underwent 1...
July 2016: Circulation. Cardiovascular Interventions
Inyoung Song, Jung Ah Park, Bo Hwa Choi, Sung Min Ko, Je Kyoun Shin, Hyun Keun Chee, Jun Seok Kim
OBJECTIVE: The aim of this study was to identify the morphological and functional characteristics of quadricuspid aortic valves (QAV) on cardiac computed tomography (CCT). MATERIALS AND METHODS: We retrospectively enrolled 11 patients with QAV. All patients underwent CCT and transthoracic echocardiography (TTE), and 7 patients underwent cardiovascular magnetic resonance (CMR). The presence and classification of QAV assessed by CCT was compared with that of TTE and intraoperative findings...
July 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Jimmy C Lu, Sunkyung Yu, Ray Lowery, Janaki Sagi, Amanda C Delong, Prachi P Agarwal, Maryam Ghadimi Mahani, Adam L Dorfman
Left ventricular (LV) ejection fraction (EF) and right ventricular (RV) ejection fraction by cardiovascular magnetic resonance (CMR) are associated with functional health status in patients with repaired tetralogy of Fallot (TOF) in cross-sectional studies, but few longitudinal data are available. This study aimed to determine predictors of subsequent decrease in functional health status in midterm follow-up. Patients with repaired TOF who had previously completed CMR and assessment with the Short Form 36 version 2 (SF-36) were recruited for repeat CMR, SF-36, and exercise test, if they had not had interval pulmonary valve replacement (PVR)...
October 2016: Pediatric Cardiology
Jonathan C L Rodrigues, Stephen Rohan, Amardeep Ghosh Dastidar, Iwan Harries, Christopher B Lawton, Laura E Ratcliffe, Amy E Burchell, Emma C Hart, Mark C K Hamilton, Julian F R Paton, Angus K Nightingale, Nathan E Manghat
OBJECTIVES: European guidelines state left ventricular (LV) end-diastolic wall thickness (EDWT) ≥15mm suggests hypertrophic cardiomyopathy (HCM), but distinguishing from hypertensive heart disease (HHD) is challenging. We identify cardiovascular magnetic resonance (CMR) predictors of HHD over HCM when EDWT ≥15mm. METHODS: 2481 consecutive clinical CMRs between 2014 and 2015 were reviewed. 464 segments from 29 HCM subjects with EDWT ≥15mm but without other cardiac abnormality, hypertension or renal impairment were analyzed...
July 1, 2016: European Radiology
Giselle Revah, Vincent Wu, Peter R Huntjens, Eve Piekarski, Janice Y Chyou, Leon Axel
Patients with left bundle branch block (LBBB) can exhibit mechanical dyssynchrony which may contribute to heart failure; such patients may benefit from cardiac resynchronization treatment (CRT). While cardiac magnetic resonance imaging (CMR) has become a common part of heart failure work-up, CMR features of mechanical dyssynchrony in patients with LBBB have not been well characterized. This study aims to investigate the potential of CMR to characterize mechanical features of LBBB. CMR examinations from 43 patients with LBBB on their electrocardiogram, but without significant focal structural abnormalities, and from 43 age- and gender-matched normal controls were retrospectively reviewed...
June 15, 2016: International Journal of Cardiovascular Imaging
Jessica M King, Katarina Kulhankova, Christopher S Stach, Bao G Vu, Wilmara Salgado-Pabón
Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. However, the virulence mechanisms associated with these clonal lineages, in particular the USA100 and USA600 isolates, have been severely understudied. We investigated the virulence of these strains, in addition to strains in the USA200, USA300, and USA400 types, in well-established in vitro assays and in vivo in the rabbit model of infective endocarditis and sepsis...
May 2016: MSphere
Johannes H Riffel, Marius G P Keller, Franziska Rost, Nisha Arenja, Florian Andre, Fabian Aus dem Siepen, Thomas Fritz, Philipp Ehlermann, Tobias Taeger, Lutz Frankenstein, Benjamin Meder, Hugo A Katus, Sebastian J Buss
BACKGROUND: Long axis strain (LAS) has been shown to be a fast assessable parameter representing global left ventricular (LV) longitudinal function in cardiovascular magnetic resonance (CMR). However, the prognostic value of LAS in cardiomyopathies with reduced left ventricular ejection fraction (LVEF) has not been evaluated yet. METHODS AND RESULTS: In 146 subjects with non-ischemic dilated cardiomyopathy (NIDCM, LVEF ≤45 %) LAS was assessed retrospectively from standard non-contrast SSFP cine sequences by measuring the distance between the epicardial border of the left ventricular apex and the midpoint of a line connecting the origins of the mitral valve leaflets in end-systole and end-diastole...
2016: Journal of Cardiovascular Magnetic Resonance
Mika Tarkiainen, Petri Sipola, Mikko Jalanko, Tiina Heliö, Mika Laine, Vesa Järvinen, Kaisu Häyrinen, Kirsi Lauerma, Johanna Kuusisto
BACKGROUND: Previous data suggest that mitral valve leaflets are elongated in hypertrophic cardiomyopathy (HCM), and mitral valve leaflet elongation may constitute a primary phenotypic expression of HCM. Our objective was to measure the length of mitral valve leaflets by cardiovascular magnetic resonance (CMR) in subjects with HCM caused by a Finnish founder mutation in the myosin-binding protein C gene (MYBPC3-Q1061X), carriers of the same mutation without left ventricular hypertrophy, as well as in unselected consecutive patients with HCM, and respective controls...
2016: Journal of Cardiovascular Magnetic Resonance
Scott Somerville, Elizabeth Rosolowsky, Somjate Suntratonpipat, Rose Girgis, Benjamin H Goot, Edythe B Tham
OBJECTIVE: To compare the detection of cardiac lesions with the use of cardiac magnetic resonance imaging (CMR) and conventional echocardiography in children with Turner syndrome. STUDY DESIGN: Twenty-four girls with Turner syndrome, 8-18 years of age, were recruited through the Pediatric Endocrinology Program. Participants underwent CMR and echocardiography within a 2-year period, and discrepancies between the results of each modality were identified. RESULTS: Fifteen of 24 (63%) girls had a cardiac lesion identified on CMR or echocardiography...
August 2016: Journal of Pediatrics
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