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Hirohisa Izumi

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https://www.readbyqxmd.com/read/29555594/ultrastructural-alteration-of-pulmonary-capillary-endothelial-glycocalyx-during-endotoxemia
#1
Risa Inagawa, Hideshi Okada, Genzou Takemura, Kodai Suzuki, Chihiro Takada, Hirohisa Yano, Yoshiaki Ando, Takahiro Usui, Yasuaki Hotta, Nagisa Miyazaki, Akiko Tsujimoto, Ryogen Zaikokuji, Atsumu Matsumoto, Tomonori Kawaguchi, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Keisuke Kumada, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura
BACKGROUND: The most recent diagnostic criteria for sepsis includes organ failure. Microvascular endothelial injury is thought to lead to the multiple organ failure seen in sepsis, although the precise mechanism is still controversial. Acute respiratory distress syndrome (ARDS) is the primary complication during the sequential development of multiple organ dysfunction in sepsis, and endothelial injury is deeply involved. Sugar-protein glycocalyx coats all healthy vascular endothelium, and its disruption is one factor thought to contribute to microvascular endothelial dysfunction during sepsis...
March 16, 2018: Chest
https://www.readbyqxmd.com/read/29518286/ingestion-of-partially-hydrolyzed-whey-protein-suppresses-epicutaneous-sensitization-to-%C3%AE-lactoglobulin-in-mice
#2
Takeshi Matsubara, Hiroshi Iwamoto, Yuki Nakazato, Tomoyuki Okamoto, Tatsuya Ehara, Hirohisa Izumi, Yasuhiro Takeda
BACKGROUND: Epicutaneous sensitization to food allergens can occur through defective skin barriers. However, the relationship between oral tolerance and epicutaneous sensitization remains to be elucidated. We aimed to determine whether prior oral exposure to whey proteins or their hydrolysates prevents epicutaneous sensitization and subsequent food-allergic reaction to the whey protein, β-lactoglobulin (β-LG), and investigated the underlying mechanisms. METHODS: BALB/c mice were given whey protein concentrate (WPC), two kinds of partial whey protein hydrolysate (PWH1 or PWH2), or extensive whey protein hydrolysate (EWH) in drinking water for 21 days...
March 8, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29459562/-the-impact-of-direct-acting-antiviral-therapy-on-the-diagnosis-of-hepatitis-c-virus-associated-hepatocellular-carcinoma
#3
Aya Takahashi, Toshihide Shima, Naohiko Kinoshita, Kota Yano, Tomoko Ueno, Masatake Nishiwaki, Yasuhide Yamamoto, Hirohisa Oya, Ichiro Amano, Junko Matsumoto, Yasuhide Mitsumoto, Izumi Tanaka, Kyoko Sakai, Naoki Sawai, Chiemi Mizuno, Masayuki Mizuno, Yoshito Itoh, Takeshi Okanoue
Since the introduction of direct-acting antiviral (DAA)-based combination therapies in September 2014 for patients with chronic hepatitis-C (CH-C), numerous patients have been diagnosed with hepatitis-C virus (HCV)-associated hepatocellular carcinomas (HCCs) during the screening performed prior to DAA therapy. The present study was conducted on the antiviral therapy for CH-C in two phases:i) the interferon (IFN) phase between January 2011 and August 2014 and ii) the DAA phase between September 2014 and September 2016...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29398122/frequency-and-characteristics-of-the-tbk1-gene-variants-in-japanese-patients-with-sporadic-amyotrophic-lateral-sclerosis
#4
Genki Tohnai, Ryoichi Nakamura, Jun Sone, Masahiro Nakatochi, Daichi Yokoi, Masahisa Katsuno, Hazuki Watanabe, Hirohisa Watanabe, Mizuki Ito, Yuanzhe Li, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Koji Abe, Ikuko Aiba, Koichi Okamoto, Kouichi Mizoguchi, Kazuko Hasegawa, Masashi Aoki, Nobutaka Hattori, Osamu Onodera, Hiroya Naruse, Jun Mitsui, Yuji Takahashi, Jun Goto, Hiroyuki Ishiura, Shinichi Morishita, Jun Yoshimura, Koichiro Doi, Shoji Tsuji, Kenji Nakashima, Ryuji Kaji, Naoki Atsuta, Gen Sobue
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease, and the etiology of sporadic ALS is generally unknown. The TANK-binding kinase 1 (TBK1) gene was identified as an ALS gene contributing to a predisposition toward ALS. To reveal the frequency and characteristics of variants of the TBK1 gene in sporadic ALS patients in Japan, we analyzed the TBK1 gene by exome sequencing in a large Japanese cohort of 713 sporadic ALS patients and 800 controls. We identified known or potentially toxic rare variants of TBK1 gene in 9 patients (1...
April 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29374613/default-mode-network-changes-in-moyamoya-disease-before-and-after-bypass-surgery-preliminary-report
#5
Yusuke Sakamoto, Sho Okamoto, Satoshi Maesawa, Epifanio Bagarinao, Yoshio Araki, Takashi Izumi, Hirohisa Watanabe, Gen Sobue, Toshihiko Wakabayashi
OBJECTIVE: Neurocognitive impairment is often reported in moyamoya disease. We aimed to detect default mode network (DMN) alterations using resting-state functional magnetic resonance imaging and their association with neurocognitive impairments. In addition, the influence of surgical treatment was individually evaluated. METHODS: Seven patients with moyamoya disease underwent preoperative resting-state functional magnetic resonance imaging and neuropsychologic tests...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29093393/retroperitoneal-perforation-caused-by-migration-of-a-pancreatic-spontaneous-dislodgement-stent-into-periampullary-diverticula
#6
Masatake Nishiwaki, Chiemi Mizuno, Kota Yano, Hirohisa Oya, Ichiro Amano, Junko Matsumoto, Izumi Tanaka, Naoki Sawai, Masayuki Mizuno, Toshihide Shima, Yoshiharu Miyamoto, Takeshi Okanoue
An 85-year-old woman underwent endoscopic retrograde cholangiopancreatography (ERCP) for obstructive jaundice. Selective bile duct cannulation was unsuccessful because of periampullary diverticula (PAD). A pancreatic spontaneous dislodgement stent (PSDS) (5F diameter, 3 cm, straight type) was inserted to prevent post-ERCP pancreatitis. Three days after ERCP, she complained of abdominal pain, and computed tomography revealed retroperitoneal perforation because of PSDS migration to the PAD. If the papillary orifice is observed at the diverticular rim or in the diverticula, a pigtailed PSDS on the duodenal side or flanged stent on the pancreatic ductal side should be inserted in order to prevent this rare adverse event...
February 1, 2018: Internal Medicine
https://www.readbyqxmd.com/read/28887635/the-prognostic-impact-of-controlling-nutritional-status-conut-in-intrahepatic-cholangiocarcinoma-following-curative-hepatectomy-a-retrospective-single-institution-study
#7
Tatsunori Miyata, Yo-Ichi Yamashita, Takaaki Higashi, Katsunobu Taki, Daisuke Izumi, Keisuke Kosumi, Ryuma Tokunaga, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba
BACKGROUND: Several studies have examined controlling nutritional status (CONUT), which is one of the useful biomarkers for predicting patients' prognosis following cancer treatment. The aim of this study was to evaluate the value of CONUT as a postoperative prognostic marker in patients with intrahepatic cholangiocarcinoma (ICC) following curative hepatectomy. METHODS: We retrospectively analyzed 71 patients who underwent curative hepatectomy for ICC between May 2002 and November 2016...
April 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/28622333/acute-40-exchange-transfusion-with-hemoglobin-vesicles-in-a-mouse-pneumonectomy-model
#8
Mitsutomo Kohno, Tatsuhiko Ikeda, Ryo Hashimoto, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Hiromi Sakai, Koichi Kobayashi, Masayuki Iwazaki
OBJECTIVES: Hemoglobin vesicles (HbVs) function as a red blood cell (RBC) substitute and are composed of purified hemoglobin encapsulated in a phospholipid bilayer membrane. The performance of HbVs as a substitute for RBC transfusions was examined in a mouse model of pneumonectomy following acute 40% exchange-transfusion with HbVs. METHODS: Before performing left pneumonectomies, 40% of the blood volume of mice was replaced with a) lactated Ringer's solution (control), b) 5% recombinant human serum albumin (rHSA), c) mouse RBCs shed in rHSA (mRBCs/rHSA), or d) HbV suspended in rHSA (HbV/rHSA)...
2017: PloS One
https://www.readbyqxmd.com/read/28595218/-disruption-of-matsui-kitamura-stent-graft-six-years-after-treatment-for-rupture-of-thoracic-aortic-aneurysm
#9
Takahiro Ishigaki, Hitoshi Matsuda, Ryuta Kawasaki, Soichiro Henmi, Hidekazu Nakai, So Izumi, Masamichi Matsumori, Hirohisa Murakami, Tasuku Honda, Masato Yoshida, Nobuhiko Mukohara
Matsui-Kitamura stent-graft (MKSG) is a home-made device for thoracic endovascular aortic repair (TEVAR) developed in Japan. A 76-year-old man who had been treated by TEVAR (zone 3) with a MKSG for ruptured thoracic aortic aneurysm was diagnosed as having type Ia endoleak caused by suture disruption and aneurysmal sac expansion 6 years later. He underwent TEVAR (zone 1) with debranching and type Ia endoleak disappeared. MKSG had been the effective device especially for acute aortic emergencies in the descending thoracic aorta until the stent-grafts became commercially available, but careful observation and appropriate re-intervention is mandatory for the continued life-saving contribution...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28133352/-a-case-of-gastrointestinal-stromal-tumor-gist-originating-in-the-anal-canal
#10
Itsuro Terada, Akemi Yoshikawa, Shogo Maruzen, Yasumichi Yagi, Shozo Sasaki, Wataru Fukushima, Hirohisa Kitagawa, Takashi Fujimura, Ryohei Izumi
We report a case of a gastrointestinal stromal tumor(GIST)that originated in the anal canal. A 70's woman with a subcutaneous tumor reaching from the anal canal was referred to our hospital. After a thorough examination, the tumor was resected percutaneously in the jackknife position. Histopathological examination showed proliferation of spindle-shaped tumor cells arranged in irregular bundles. Immunohistochemical staining showed that the tumor was positive for c-kit and CD34, and negative for a-SMA and S-100, so the tumor was diagnosed as GIST...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27431633/-a-study-of-patients-with-regional-lymph-node-recurrence-after-breast-surgery
#11
Wataru Fukushima, Shogo Maruzen, Yasumichi Yagi, Shozo Sasaki, Itsuro Terada, Akemi Yoshikawa, Hirohisa Kitagawa, Takashi Fujimura, Ryohei Izumi, Katsuhiko Saito
Regional lymph node recurrence without distant metastasis after the initial treatment of breast cancer is a relatively rare event. The optimal management for regional lymph node recurrence is poorly understood. We retrospectively evaluated 21 patients who developed regional lymph node recurrence between January 1, 2003 and December 31, 2014. The median interval between regional lymph node recurrence and distant metastasis was 1.0 years(range, 0.4 to 2.5 years). On followup, 15 cases(71.4%)were found to eventually develop distant metastases...
July 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27423564/japanese-version-of-the-als-ftd-questionnaire-als-ftd-q-j
#12
MULTICENTER STUDY
Yasuhiro Watanabe, Emma Beeldman, Joost Raaphorst, Yuishin Izumi, Hiide Yoshino, Michihito Masuda, Naoki Atsuta, Satoru Ito, Tadashi Adachi, Yoshiki Adachi, Osamu Yokota, Masaya Oda, Ritsuko Hanashima, Mieko Ogino, Hiroo Ichikawa, Kazuko Hasegawa, Hideki Kimura, Toshio Shimizu, Ikuko Aiba, Hayato Yabe, Makoto Kanba, Kimiyoshi Kusumi, Tetsuya Aoki, Yu Hiroe, Hirohisa Watanabe, Kazutoshi Nishiyama, Masahiro Nomoto, Gen Sobue, Kenji Nakashima
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share common clinical, genetic and neuropathological features. Some ALS patients have behavioral/personality changes, which could result in significant obstacles in the care provided by family members and caregivers. An easy screening tool would contribute greatly to the evaluation of these symptoms. We translated the ALS-FTD-Questionnaire, developed in the Netherlands, into Japanese (ALS-FTD-Q-J) and examined the clinimetric properties (internal consistency, construct and clinical validity)...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27198516/combinational-effects-of-prebiotic-oligosaccharides-on-bifidobacterial-growth-and-host-gene-expression-in-a-simplified-mixed-culture-model-and-neonatal-mice
#13
Tatsuya Ehara, Hirohisa Izumi, Muneya Tsuda, Yuki Nakazato, Hiroshi Iwamoto, Kazuyoshi Namba, Yasuhiro Takeda
It is important to provide formula-fed infants with a bifidobacteria-enriched gut microbiota similar to those of breastfed infants to ensure intestinal health. Prebiotics, such as certain oligosaccharides, are a useful solution to this problem, but the combinational benefits of these oligosaccharides have not been evaluated. This study investigated the benefits of oligosaccharide combinations and screened for an optimal combination of oligosaccharides to promote healthy gut microbiota of formula-fed infants...
July 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27083563/age-of-onset-differentially-influences-the-progression-of-regional-dysfunction-in-sporadic-amyotrophic-lateral-sclerosis
#14
MULTICENTER STUDY
Daichi Yokoi, Naoki Atsuta, Hazuki Watanabe, Ryoichi Nakamura, Akihiro Hirakawa, Mizuki Ito, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Masaya Oda, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Satoshi Kuwabara, Ryuji Kaji, Gen Sobue
The clinical courses of sporadic amyotrophic lateral sclerosis (ALS) show extensive variability. Our objective was to elucidate how age of onset influences the progression of regional symptoms and functional losses in sporadic ALS. We included 648 patients with sporadic ALS from a multicenter prospective ALS cohort. We investigated the distribution of initial symptoms and analyzed the time from onset to events affecting activities of daily living (ADL) as well as the longitudinal changes in each regional functional rating score among four groups with different ages of onset...
June 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26987428/epicutaneous-allergic-sensitization-by-cooperation-between-allergen-protease-activity-and-mechanical-skin-barrier-damage-in-mice
#15
Sakiko Shimura, Toshiro Takai, Hideo Iida, Natsuko Maruyama, Hirono Ochi, Seiji Kamijo, Izumi Nishioka, Mutsuko Hara, Akira Matsuda, Hirohisa Saito, Susumu Nakae, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda
Allergen sources such as mites, insects, fungi, and pollen contain proteases. Airway exposure to proteases induces allergic airway inflammation and IgE/IgG1 responses via IL-33-dependent mechanisms in mice. We examined the epicutaneous sensitization of mice to a model protease allergen, papain; the effects of tape stripping, which induces epidermal barrier dysfunction; and the atopic march upon a subsequent airway challenge. Papain painting on ear skin and tape stripping cooperatively promoted dermatitis, the skin gene expression of proinflammatory cytokines and growth factors, up-regulation of serum total IgE, and papain-specific IgE/IgG1 induction...
July 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26746183/a-rapid-functional-decline-type-of-amyotrophic-lateral-sclerosis-is-linked-to-low-expression-of-ttn
#16
Hazuki Watanabe, Naoki Atsuta, Akihiro Hirakawa, Ryoichi Nakamura, Masahiro Nakatochi, Shinsuke Ishigaki, Aritoshi Iida, Shiro Ikegawa, Michiaki Kubo, Daichi Yokoi, Hirohisa Watanabe, Mizuki Ito, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Kazuaki Kanai, Akira Taniguchi, Ikuko Aiba, Koji Abe, Koichi Mizoguchi, Masaya Oda, Osamu Kano, Koichi Okamoto, Satoshi Kuwabara, Kazuko Hasegawa, Takashi Imai, Akihiro Kawata, Masashi Aoki, Shoji Tsuji, Kenji Nakashima, Ryuji Kaji, Gen Sobue
OBJECTIVE: To classify the patterns of functional decline in patients with sporadic amyotrophic lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns. METHODS: We included 465 patients with sporadic ALS in the analysis and clustered the longitudinal functional scores in the registered patients, using a mixture approach of a non-linear mixed-effects model. We conducted a genome-wide analysis of 572 983 single nucleotide polymorphisms (SNPs)...
August 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26616485/-an-autopsy-case-of-progressive-generalized-muscle-atrophy-over-14-years-due-to-post-polio-syndrome
#17
REVIEW
Ryosuke Oki, Akiko Uchino, Yuishin Izumi, Hirohisa Ogawa, Shigeo Murayama, Ryuji Kaji
We report the case of a 72-year-old man who had contracted acute paralytic poliomyelitis in his childhood. Thereafter, he had suffered from paresis involving the left lower limb, with no relapse or progression of the disease. He began noticing slowly progressive muscle weakness and atrophy in the upper and lower extremities in his 60s. At the age of 72, muscle weakness developed rapidly, and he demonstrated dyspnea on exertion and dysphagia. He died after about 14 years from the onset of muscle weakness symptoms...
2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/26463667/massive-pneumoretroperitoneum-arising-from-emphysematous-cholecystitis-a-case-report-and-the-literature-review
#18
REVIEW
Yasumichi Yagi, Shozo Sasaki, Itsuro Terada, Akemi Yoshikawa, Wataru Fukushima, Hirohisa Kitagawa, Takashi Fujimura, Ryohei Izumi, Katsuhiko Saito
BACKGROUND: Emphysematous cholecystitis is a severe variant of acute cholecystitis caused by anaerobic bacteria. Although intraperitoneal air as a complication has been described in association with emphysematous cholecystitis, pneumoretroperitoneum arising from emphysematous cholecystitis is extremely rare. Herein, we describe a rare case of pneumoretroperitoneum arising from emphysematous cholecystitis that was successfully treated with emergency surgery. CASE PRESENTATION: An 84-year-old male was transported to the Emergency Department of our hospital for acute abdomen...
September 8, 2015: BMC Gastroenterology
https://www.readbyqxmd.com/read/26305023/prognostic-impact-of-visceral-fat-amount-and-branched-chain-amino-acids-bcaa-in-hepatocellular-carcinoma
#19
Takaaki Higashi, Hiromitsu Hayashi, Takayoshi Kaida, Kota Arima, Hideaki Takeyama, Katsunobu Taki, Daisuke Izumi, Ryuma Tokunaga, Keisuke Kosumi, Shigeki Nakagawa, Hirohisa Okabe, Katsunobu Imai, Hidetoshi Nitta, Daisuke Hashimoto, Akira Chikamoto, Toru Beppu, Hideo Baba
BACKGROUND: Dysregulation of lipid and amino acid metabolism in patients with liver diseases results in obesity-related carcinogenesis and decreased levels of branched-chain amino acids (BCAA), respectively. This study assessed the clinical and prognostic impact of visceral fat amount (VFA) and its association with amino acid metabolism in patients with hepatocellular carcinoma (HCC). METHODS: In this study, 215 patients who underwent hepatic resection for HCC were divided into two groups based on VFA criteria for metabolic abnormalities in Japan...
December 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26083761/bifidobacterium-breve-alters-immune-function-and-ameliorates-dss-induced-inflammation-in-weanling-rats
#20
Hirohisa Izumi, Mario Minegishi, Yohei Sato, Takashi Shimizu, Kazunori Sekine, Mitsunori Takase
BACKGROUND: Bifidobacterium breve M-16V (M16V) is a probiotic bacterial strain with a long tradition of use in neonatal intensive care units in some countries. Previous study showed that the effects of M16V administration on gene expression were greater during the weaning period than in the neonatal period and were greater in the colon than in the small intestine and spleen, suggesting that M16V has anti-inflammatory effects. In this study, we evaluated the effects of inflammation during the weaning period and the effects of M16V on normal and inflammatory conditions...
October 2015: Pediatric Research
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