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https://www.readbyqxmd.com/read/28341042/effect-of-forage-to-concentrate-ratio-with-sorghum-silage-as-a-source-of-forage-on-rumen-fermentation-n-balance-and-purine-derivative-excretion-in-limit-fed-dairy-heifers
#1
K Kljak, F Pino, A J Heinrichs
Sorghum silage has been shown to be a good alternative to corn silage for dairy cows; however, studies regarding heifers are insufficiently explored. Therefore, the objective of this study was to evaluate effects of changing forage to concentrate ratio (FOR:CON) in diets based on sorghum silage on N digestibility, rumen fermentation, N balance, C excretion, and microbial N yield in limit-fed dairy heifers. A split-plot 4×4 Latin square design with 19-d periods (15 d of adaptation and 4 d of sampling) was conducted with 8 rumen cannulated dairy heifers (age 13...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28340139/assessment-of-acute-kidney-injury-in-rhabdomyolytic-mice-by-transcutaneous-measurement-of-sinistrin-excretion
#2
Aldo Moggio, Stefania Geraci, Alberto Boido, Carsten Sticht, Norbert Gretz, Benedetta Bussolati
Background: . Early and accurate assessment of renal function is required for the successful detection and treatment of acute kidney injury (AKI). However, only retention parameters such as plasma urea and creatinine, and the indirect estimation of glomerular filtration rate are commonly available. Methods.: Here, we measured the kinetics of plasma fluorescein isothiocyanate (FITC)-sinistrin excretion to detect alterations of renal function over time in a murine model of rhabdomyolysis-induced AKI...
February 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28328817/retrospective-analysis-of-the-overt-proteinuria-diabetic-kidney-disease-in-the-treatment-of-modified-shenzhuo-formula-for-2-years
#3
Hongdong Chen, Jing Guo, Xuemin Zhao, Xinhui He, Zhongchen He, Linhua Zhao, Xiaolin Tong
The objective of the present study was to evaluate the 2-year effectiveness of modified Shenzhuo formula in the treatment of overt proteinuria diabetic kidney disease (DKD).Patients diagnosed with type 2 DKD in the clinical research database of Prof Xiaolin Tong (>20,000 data points) with >1-year follow-up were screened for this study. Patients' demographic data, chief complaint, present illness, past history, allergic history, personal history, family history, test results, tongue images, pulse information, and prescription information at 1, 1...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28324156/molecular-characterization-of-two-rhesus-glycoproteins-from-the-euryhaline-freshwater-white-rimmed-stingray-himantura-signifer-and-changes-in-their-transcript-levels-and-protein-abundance-in-the-gills-kidney-and-liver-during-brackish-water-acclimation
#4
Cheng T Yeam, You R Chng, Jasmine L Y Ong, Wai P Wong, Shit F Chew, Yuen K Ip
Himantura signifer is a freshwater stingray which inhabits rivers in Southeast Asia. It is ammonotelic in fresh water, but retains the capacities of urea synthesis and ureosmotic osmoregulation to survive in brackish water. This study aimed to elucidate the roles of Rhesus glycoproteins (Rhgp), which are known to transport ammonia, in conserving nitrogen (N) in H. signifer during brackish water acclimation when N became limited resulting from increased hepatic urea synthesis. The complete coding sequence of rhbg from H...
March 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28322418/associations-of-sodium-potassium-and-protein-intake-with-blood-pressure-and-hypertension-in-switzerland
#5
Nicolas Glatz, Aline Chappuis, David Conen, Paul Erne, Antoinette Péchère-Bertschi, Idris Guessous, Valentina Forni, Luca Gabutti, Franco Muggli, Augusto Gallino, Daniel Hayoz, Isabelle Binet, Paolo Suter, Fred Paccaud, Murielle Bochud, Michel Burnier
BACKGROUND: Nutritional factors play an important role in the regulation of blood pressure and in the development of hypertension. In this analysis, we explored the associations of 24-hour urinary Na+, K+ and urea excretion with blood pressure levels and the risk of hypertension in the Swiss population, taking regional linguistic differences into account. METHODS: The Swiss Survey on Salt is a population based cross-sectional study that included 1336 subjects from the three main linguistic regions (French, German and Italian) of Switzerland...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28315683/klotho-ameliorates-cyclosporine-a-induced-nephropathy-via-pdlim2-nf-kb-p65-signaling-pathway
#6
Meihua Jin, Pengfei Lv, Guanyu Chen, Peng Wang, Zhongfu Zuo, Lili Ren, Jing Bi, Chul-Woo Yang, Xifan Mei, Donghe Han
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney diseases (CKD). To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks. Also, primary human renal proximal tubule epithelial cells (RPTECs) were treated with soluble Klotho protein and LPS...
March 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28302561/ameliorative-effect-of-gossypin-against-gentamicin-induced-nephrotoxicity-in-rats
#7
Mohamed Katary, Ahmad Salahuddin
AIM: Gentamicin (GEN) is an aminoglycoside antibiotic employed in treatment of life-threatening gram-negative infections, but one of its major side effects is the induction of nephrotoxicity. Therefore, the aim of this work was to scrutinize the possible protective effect of gossypin against GEN-induced nephrotoxicity. METHOD: Rats were randomly divided into four groups. First group served as a control, second group was injected with gossypin (10mg/kg, orally) for 7days, third group was injected with GEN (80mg/kg, i...
March 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/28274925/salt-supplementation-ameliorates-developmental-kidney-defects-in-cox-2-mice
#8
Patrick Slattery, Stefanie Frölich, Itamar Goren, Rolf Michael Nüsing
Deficiency of cyclooxygenase-2 (COX-2) activity in the early postnatal time course causes impairment of kidney development leading to kidney insufficiency. We hypothesize that impaired NaCl reabsorption during the first days of life is a substantial cause for nephrogenic defects observed in COX-2-/- mice and that salt supplementation corrects these defects. Daily injections of 0.8 mg/g/d NaCl for the first 10 days after birth ameliorated impaired kidney development in COX-2-/- pups resulting in an increase in glomerular size and reduction of immature superficial glomeruli...
March 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28270647/protective-effect-of-thymoquinone-against-morphine-injuries-to-kidneys-of-mice
#9
Cyrus Jalili, Mohammad Reza Salahshoor, Mohsen Hoseini, Shiva Roshankhah, Maryam Sohrabi, Ahmad Shabanizadeh
INTRODUCTION: Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It has various pharmacological effects such as antioxidant and anti-apoptotic. Morphine can increase the generation of free radicals. It is mainly excreted through the kidneys and causes disturbing effects. This study was designed to evaluate protective effects of thymoquinone against morphine-induced damages to the kidneys of mice. MATERIALS AND METHODS: Various doses of thymoquinone (4...
March 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28261105/aestivation-induces-changes-in-the-mrna-expression-levels-and-protein-abundance-of-two-isoforms-of-urea-transporters-in-the-gills-of-the-african-lungfish-protopterus-annectens
#10
You R Chng, Jasmine L Y Ong, Biyun Ching, Xiu L Chen, Kum C Hiong, Wai P Wong, Shit F Chew, Siew H Lam, Yuen K Ip
The African lungfish, Protopterus annectens, is ammonotelic in water despite being ureogenic. When it aestivates in mucus cocoon on land, ammonia is detoxified to urea. During the maintenance phase of aestivation, urea accumulates in the body, which is subsequently excreted upon arousal. Urea excretion involves urea transporters (UT/Ut). This study aimed to clone and sequence the ut isoforms from the gills of P. annectens, and to test the hypothesis that the mRNA and/or protein expression levels of ut/Ut isoforms could vary in the gills of P...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28260151/the-effects-of-acute-copper-and-ammonia-challenges-on-ammonia-and-urea-excretion-by-the-blue-crab-callinectes-sapidus
#11
Alex M Zimmer, Marianna Basso Jorge, Chris M Wood, Camila M G Martins, Adalto Bianchini
Copper (Cu) is a persistent environmental contaminant that elicits several physiological disturbances in aquatic organisms, including a disruption in ammonia regulation. We hypothesized that exposure to Cu in a model crustacean (blue crab, Callinectes sapidus) acclimated to brackish water (2 ppt) would lead to hyperammonemia by stimulating an increase in ammonia production and/or by inhibiting ammonia excretion. We further hypothesized that urea production would represent an ammonia detoxification strategy in response to Cu...
April 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28259401/replacing-alfalfa-silage-with-tannin-containing-birdsfoot-trefoil-silage-in-total-mixed-rations-for-lactating-dairy-cows
#12
G A Broderick, J H Grabber, R E Muck, U C Hymes-Fecht
Two lactation trials were conducted comparing the feeding value of silages made from birdsfoot trefoil (BFT, Lotus corniculatus L.) that had been selected for low (BFTL), medium (BFTM), and high (BFTH) levels of condensed tannins (CT) to an alfalfa silage (AS) when fed as the principal forage in total mixed rations. Diets also included corn silage, high-moisture shelled corn, soybean meal, soy hulls, and supplemental fat. In trial 1, 32 lactating Holstein cows were blocked by days in milk, assigned to treatment sequences in 8 balanced 4 × 4 Latin squares, and fed 50% dietary dry matter from AS or 1 of 3 BFT silages containing 0...
March 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28236109/effect-of-administration-of-high-protein-diet-in-rats-submitted-to-resistance-training
#13
Thiago da Rosa Lima, Eudes Thiago Pereira Ávila, Géssica Alves Fraga, Mariana de Souza Sena, Arlyson Batista de Souza Dias, Paula Caroline de Almeida, Joice Cristina Dos Santos Trombeta, Roberto Carlos Vieira Junior, Amílcar Sabino Damazo, James Wilfred Navalta, Jonato Prestes, Fabrício Azevedo Voltarelli
PURPOSE: Although there is limited evidence regarding the pathophysiological effects of a high-protein diet (HD), it is believed that this type of diet could overload the body and cause damage to the organs directly involved with protein metabolism and excretion. The aim of this study was to verify the effects of HD on biochemical and morphological parameters of rats that completed a resistance training protocol (RT; aquatic jump) for 8 weeks. METHODS: Thirty-two adult male Wistar rats were divided into four groups (n = 8 for each group): sedentary normal protein diet (SN-14%), sedentary high-protein diet (SH-35%), trained normal protein diet (TN-14%), and trained high-protein diet (TH-35%)...
February 24, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28218578/bone-marrow-derived-mesenchymal-stem-cells-ameliorate-nephrosis-through-repair-of-impaired-podocytes
#14
Yi Chen, Jun Chen, Jianxin Wan, Na Gao, Jiong Cui, Danyu You, Zhenhuan Zou
PURPOSE: The purpose of this study was to investigate the effects of bone marrow-derived mesenchymal stem cells (BMSC) on podocytes of puromycin amino nuclear glucoside (PAN) -induced nephrosis in mice. METHODS: Mice were randomly divided into Control, PAN and BMSC groups. Mice were injected with PAN (0.5 mg/g weight) via the tail vein. The 24-h urinary protein was obtained after modelling, and urinary protein excretion was determined. The blood and kidney specimens were isolated after the tenth day of modelling...
February 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28205048/mild-orotic-aciduria-in-umps-heterozygotes-a-metabolic-finding-without-clinical-consequences
#15
Saskia B Wortmann, Margaret A Chen, Roberto Colombo, Alessandro Pontoglio, Bader Alhaddad, Lorenzo D Botto, Tatiana Yuzyuk, Curtis R Coughlin, Maria Descartes, Stephanie Grűnewald, Bruno Maranda, Philippa B Mills, James Pitt, Catherine Potente, Richard Rodenburg, Leo A J Kluijtmans, Srirangan Sampath, Emil F Pai, Ron A Wevers, George E Tiller
BACKGROUND: Elevated urinary excretion of orotic acid is associated with treatable disorders of the urea cycle and pyrimidine metabolism. Establishing the correct and timely diagnosis in a patient with orotic aciduria is key to effective treatment. Uridine monophosphate synthase is involved in de novo pyrimidine synthesis. Uridine monophosphate synthase deficiency (or hereditary orotic aciduria), due to biallelic mutations in UMPS, is a rare condition presenting with megaloblastic anemia in the first months of life...
February 15, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28202885/tolvaptan-reduces-the-risk-of-worsening-renal-function-in-patients-with-acute-decompensated-heart-failure-and-preserved-left-ventricular-ejection-fraction%C3%A3-prospective-randomized-controlled-study
#16
Shunsuke Tamaki, Yoshihiro Sato, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tatsuhisa Ozaki, Masahiro Seo, Iyo Ikeda, Eiji Fukuhara, Makoto Abe, Jun Nakamura, Masatake Fukunami
BACKGROUND: Although the mainstay of treatment for acute decompensated heart failure (ADHF) is decongestion by diuretic therapy, it is often associated with worsening renal function (WRF). The effect of tolvaptan, a selective V2 receptor antagonist, on WRF in ADHF patients with preserved left ventricular ejection fraction (LVEF) is unknown.Methods and Results:We enrolled 50 consecutive ADHF patients whose LVEF on admission was ≥45%. Patients were randomly assigned to either tolvaptan add-on (n=26) or conventional diuretic therapy (n=24)...
February 16, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28179254/a-mathematical-model-of-the-rat-kidney-k-induced-natriuresis
#17
Alan M Weinstein
A model of the rat nephron (Am. J. Physiol. 308:F1098, 2015) has been extended with addition of medullary vasculature. Blood vessels contain solutes from the nephron model, plus additional species from the model of Atherton et al. (Am. J. Physiol. 247:F61, 1984), representing hemoglobin buffering. In contrast to prior models of the urine concentrating mechanism, reflection coefficients for DVR are near zero. Model unknowns are initial proximal tubule pressures and flows, connecting tubule pressure, and medullary interstitial pressures and concentrations...
February 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28177373/a-strategy-to-improve-nitrogen-utilization-reduce-environmental-impact-and-increase-performance-and-antioxidant-capacity-of-fattening-lambs-using-pomegranate-peel-extract
#18
M Rajabi, Y Rouzbehan, J Rezaei
Dietary natural plant secondary metabolites (PSM) extracted from a pomegranate peel (PP) byproduct have the potential to improve milk yield and the milk fatty acid profile of dairy cows. This experiment was performed to assess the influence of different dietary levels of PP extract (PPE) on feedlot performance, ruminal status, nutrient utilization, and antioxidant status in fattening Moghani lambs. Thirty-two lambs (initial BW of 22 ± 1.2 kg) were used in a completely randomized design with a 72-d period and 4 treatments: PPE0 (no extract), PPE15 (15 mL PPE/kg of diet DM), PPE30 (30 mL PPE/kg of diet DM), and PPE45 (45 mL PPE/kg of diet DM)...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28174217/diagnosis-and-treatment-of-hyponatremia-compilation-of-the-guidelines
#19
Ewout J Hoorn, Robert Zietse
Hyponatremia is a common water balance disorder that often poses a diagnostic or therapeutic challenge. Therefore, guidelines were developed by professional organizations, one from within the United States (2013) and one from within Europe (2014). This review discusses the diagnosis and treatment of hyponatremia, comparing the two guidelines and highlighting recent developments. Diagnostically, the initial step is to differentiate hypotonic from nonhypotonic hyponatremia. Hypotonic hyponatremia is further differentiated on the basis of urine osmolality, urine sodium level, and volume status...
February 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28131569/histidine-deficiency-has-a-negative-effect-on-lactational-performance-of-dairy-cows
#20
F Giallongo, M T Harper, J Oh, C Parys, I Shinzato, A N Hristov
A 10-wk randomized complete block design experiment with 24 Holstein cows was conducted to investigate the long-term effects of feeding a His-deficient diet on lactational performance of dairy cows. Cows were blocked by days in milk, milk yield, and parity, and randomly assigned to 1 of the following 2 treatments: (1) His-adequate diet [HAD; providing +166 g/d over metabolizable protein (MP) requirements, according to the National Research Council (2001) and digestible His (dHis) supply of 68 g/d, or 2.5% of MP requirements] and (2) His-deficient diet (HDD; +37 g/d over MP requirements and dHis supply of 49 g/d, or 1...
January 25, 2017: Journal of Dairy Science
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