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https://www.readbyqxmd.com/read/28650699/effect-of-euterpe-oleracea-mart-seeds-extract-on-chronic-ischemic-renal-injury-in-renovascular-hypertensive-rats
#1
Cristiane Aguiar da Costa, Dayane Teixeira Ognibene, Viviane Silva Cristino Cordeiro, Graziele Freitas de Bem, Izabelle Barcellos Santos, Ricardo Andrade Soares, Letícia L de Melo Cunha, Lenize C R M Carvalho, Roberto Soares de Moura, Angela Castro Resende
Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (açaí) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of açaí (ASE) fruits in two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C and sham groups. Animals received ASE (200 mg/(kg·day) in drinking water) or vehicle for 40 days. We evaluated serum and urinary parameters, renal structural changes, and oxidative status...
June 26, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28648206/how-to-assess-the-efficacy-of-phosphate-binders
#2
Francisco Caravaca, Fernando Caravaca-Fontán, Lilia Azevedo, Enrique Luna
BACKGROUND AND AIMS: The efficacy of phosphate binders is difficult to be estimated clinically. This study analyzes the changes in serum phosphate and urinary phosphate excretion after the prescription of phosphate binders (PB) in patients with chronic kidney disease stage 4-5 pre-dialysis, and the usefulness of the ratio between total urinary phosphate and protein catabolic rate (Pu/PCR) for estimating the efficacy of PB. METHODS: This retrospective observational cohort study included adult chronic kidney disease patients...
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28645705/acid-load-and-phosphorus-homeostasis-in-ckd
#3
Pascale Khairallah, Tamara Isakova, John Asplin, Lee Hamm, Mirela Dobre, Mahboob Rahman, Kumar Sharma, Mary Leonard, Edgar Miller, Bernard Jaar, Carolyn Brecklin, Wei Yang, Xue Wang, Harold Feldman, Myles Wolf, Julia J Scialla
BACKGROUND: The kidneys maintain acid-base homeostasis through excretion of acid as either ammonium or as titratable acids that primarily use phosphate as a buffer. In chronic kidney disease (CKD), ammoniagenesis is impaired, promoting metabolic acidosis. Metabolic acidosis stimulates phosphaturic hormones, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) in vitro, possibly to increase urine titratable acid buffers, but this has not been confirmed in humans. We hypothesized that higher acid load and acidosis would associate with altered phosphorus homeostasis, including higher urinary phosphorus excretion and serum PTH and FGF-23...
June 21, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28638881/aristolochia-bracteolate-retz-attenuates-hyperuricemia-in-a-metabolic-arthritis-rat-model
#4
Yun-Peng Li, Shuang Wu, Afou Ran, Da-Yong Xu, Jing-Mei Wei, Zi-Long Zhao
BACKGROUND: The leaves of Aristolochia bracteolata Retz. has been documented in the folk medicine literature for its anti-arthritic activity. The target of the research envisaged was to elucidate the activity of A. bracteolata extract on hyperuricemic condition in arthritis rat model. MATERIALS AND METHODS: Dried and powdered plant leaves were extracted using ether and chloroform. Potassium oxonate was injected intra-articularly to produce arthritis. The hyperuricemic effect, of A...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28614828/relationship-between-sodium-intake-and-water-intake-the-false-and-the-true
#5
Lise Bankir, Julie Perucca, Peter Norsk, Nadine Bouby, Morten Damgaard
Generally, eating salty food items increases thirst. Thirst is also stimulated by the experimental infusion of hypertonic saline. But, in steady state, does the kidney need a higher amount of water to excrete sodium on a high than on a low sodium intake? This issue is still controversial. The purpose of this review is to provide examples of how the kidney handles water in relation to salt intake/output. It is based on re-analysis of previously published studies in which salt intake was adjusted to several different levels in the same subjects, and in databases of epidemiologic studies in populations on an ad libitum diet...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28608638/effect-of-different-levels-of-copper-nanoparticles-and-copper-sulphate-on-performance-metabolism-and-blood-biochemical-profiles-in-broiler-chicken
#6
A Scott, K P Vadalasetty, M Łukasiewicz, S Jaworski, M Wierzbicki, A Chwalibog, E Sawosz
A study was conducted to investigate the influence of copper administration in ovo to chicken embryos and/or supplied in drinking water to growing chickens in the form copper nanoparticles (Cu-NP) or copper sulphate (CuSO4 ). The fertilised eggs were assigned to three groups (n = 50 per group): control (not injected), injected with 50 mg/kg Cu-NP or with 50 mg/kg CuSO4 at day 1 of incubation. Thereafter, 126 one-day-old broiler chickens were randomly assigned to seven post-hatched groups: control not injected and not provided with Cu in the drinking water, injected with 50 mg/kg Cu-NP + 20 mg/kg in water, not injected + 20 mg/kg Cu-NP in water, injected with 50 mg/kg CuSO4  + 20 mg/kg in water, not injected + 20 mg/kg CuSO4 in water, injected with 50 mg/kg Cu-NP and injected with 50 mg/kg CuSO4 ...
June 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28607409/functional-characterization-of-aquaporin-like-genes-in-the-human-bed-bug-cimex-lectularius
#7
Hitoshi Tsujimoto, Joyce M Sakamoto, Jason L Rasgon
The bed bug Cimex lectularius is a blood-feeding re-emerging annoyance pest insect that has the ability to transmit Trypanosoma cruzi under experimental laboratory conditions. Aquaporins (AQPs) are water channel proteins that are essential in biological organisms. C. lectularius are constantly exposed to water-related stress, suggesting that AQPs may offer novel control avenues. We identified and cloned four AQPs from C. lectularius, assessed tissue and lifestage-specific expression, and characterized biochemical functions in vitro and in vivo...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28601456/inclusion-of-wheat-and-triticale-silage-in-the-diet-of-lactating-dairy-cows
#8
M T Harper, J Oh, F Giallongo, G W Roth, A N Hristov
The objective of this experiment was to partially replace corn silage with 2 alternative forages, wheat (Triticum aestivum) or triticale (X Triticosecale) silages at 10% of the diet dry matter (DM), and investigate the effects on dairy cow productivity, nutrient utilization, enteric CH4 emissions, and farm income over feed costs. Wheat and triticale were planted in the fall as cover crops and harvested in the spring at the boot stage. Neutral- and acid-detergent fiber and lignin concentrations were higher in the wheat and triticale silages compared with corn silage...
June 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28601445/production-and-nitrogen-utilization-in-lactating-dairy-cows-fed-ground-field-peas-with-or-without-ruminally-protected-lysine-and-methionine
#9
A B D Pereira, N L Whitehouse, K M Aragona, C S Schwab, S F Reis, A F Brito
Previous research has shown that cows fed ≥24% of the diet dry matter (DM) as field peas decreased milk yield as well as concentration and yield of milk protein, possibly due to reduced DM intake and limited supply of Lys and Met. Twelve multiparous and 4 primiparous lactating Holstein cows were randomly assigned to 1 of 4 diets in a replicated 4 × 4 Latin square design. The diets contained (DM basis) 34.8% corn silage, 15.2% grass-legume silage, 5.9% roasted soybean, 2.4% mineral-vitamin premix, 2.0% alfalfa pellets, and either (1) 36% ground corn, 2...
June 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28601120/measurement-of-breath-ammonia-for-detection-of-patients-with-chronic-kidney-disease
#10
Sebastjan Bevc, Eva Mohorko, Mitja Kolar, Polona Brglez, Andrej Holobar, Daniela Kniepeiss, Matej Podbregar, Nejc Piko, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: In a healthy individual, ammonia is converted to urea in the liver. Urea is then transported through the bloodstream and then excreted into the urine by the kidneys. In patients with chronic kidney disease (CKD), the accumulated urea is degraded by salivary urease into ammonia, which is then excreted by breathing. Breath ammonia can therefore be used for detecting the increased nitrogen-bearing wastes. In our pilot study, an electrochemical sensor was used to measure and analyze breath ammonia in healthy volunteers and patients with CKD...
June 9, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28599386/amelioration-of-hyperglycemia-and-associated-metabolic-abnormalities-by-a-combination-of-fenugreek-trigonella-foenum-graecum-seeds-and-onion-allium-cepa-in-experimental-diabetes
#11
Seetur R Pradeep, Krishnapura Srinivasan
BACKGROUND: Fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) are independently known to have antidiabetic effects through different mechanisms. The beeneficial influence of a combination of dietary fenugreek seeds and onion on hyperglycemia and its associated metabolic abnormalities were evaluated in streptozotocin-induced diabetic rats. METHODS: Diabetes was experimentally induced with streptozotocin and diabetic rats were fed with 10% fenugreek or 3% onion or their combination for 6 weeks...
May 24, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28577234/antagonistic-effect-of-laver-pyropia-yezonensis-and-p-haitanensis-on-subchronic-lead-poisoning-in-rats
#12
Yingying Guo, Xiaohui Gu, Yanhua Jiang, Wenjia Zhu, Lin Yao, Zhantao Liu, Hua Gao, Lianzhu Wang
Lead, one of the most harmful heavy metals, can cause various hazardous effects on living organisms. This study was undertaken to evaluate the antagonistic and protective effects of two economically important laver species, Pyropia yezoensis and P. haitanensis, against subchronic lead poisoning in rats by a 30-day feeding test. Sixty-four healthy Wistar rats were randomly divided into eight groups with eight rats (4♂ + 4♀) per group, among which, one group was served as the control, the others were respectively treated with lead acetate (5 mg/kg b w), and a combination of lead acetate and P...
June 3, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28553862/the-possible-protective-effect-of-l-arginine-against-5-fluorouracil-induced-nephrotoxicity-in-male-albino-rats
#13
Mohamed H Badawoud, Eman B Elshal, Azza I Zaki, Hanan A Amin
5-fluorouracil (5-FU) is a potent antineoplastic agent used for the treatment of various malignancies. The L-argininenitric oxide (NO) pathway involved in the pathogenesis of chemotherapy induced kidney damage. This work investigated the beneficial mechanism of L-arginine supplementation in 5 FU induced nephropathy. Eighty male Wistar rats were divided into four equal groups: Control group; L-arginine group (378 mg/rat /day for 4 weeks); 5-FU group (189 mg/rat/week for 4 weeks) and L-arginine for one week before and 4 weeks concomitant with 5-FU group...
May 29, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28551194/effects-of-shortening-the-close-up-period-length-coupled-with-increased-supply-of-metabolizable-protein-on-performance-and-metabolic-status-of-multiparous-holstein-cows
#14
T Amirabadi Farahani, H Amanlou, M Kazemi-Bonchenari
This experiment was conducted to compare conventional (CON; 21 d) and shortened (SH; 10 d) close-up period, and evaluate the effect of shortened close-up period combined with feeding different metabolizable protein (MP) levels on dry matter (DM) intake, metabolic status, and performance of dairy cows. Forty-eight multiparous Holstein cows with similar parity, body weight (BW), and previous lactation milk yield were divided into 2 groups. The first group (n = 24) received the far-off diet from -60 to -21 d (CON), and the second group (n = 24) received same far-off diet from -60 to -10 d (SH) relative to expected parturition...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28550063/an-environment-friendly-engineered-azotobacter-can-replace-substantial-amount-of-urea-fertilizer-and-yet-sustain-same-wheat-yield
#15
Umesh K Bageshwar, Madhulika Srivastava, Pedisetty Pardha-Saradhi, Sangeeta Paul, Sellamuthu Gothandapani, Ranjeet S Jaat, Prabha Shankar, Rajbir Yadav, Dipak R Biswas, Polumetla A Kumar, Jasdeep C Padaria, Pranab K Mandal, Kannepalli Annapurna, Hirendra K Das
In our endeavor to improve upon nitrogen fixation efficiency of a soil diazotroph that would be unaffected by synthetic nitrogenous fertilizers, we have deleted a part of the negative regulatory gene nifL and constitutively expressed the positive regulatory gene nifA in the chromosome of Azotobacter chroococcum CBD15, a strain isolated from the local field soil. No antibiotic resistance gene or other foreign gene was there in the chromosome of the engineered strain. Wheat seeds inoculated with this engineered strain, which we have named Azotobacter chroococcum HKD15, were tested for three years in pots and one year in the field...
May 26, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28529539/jiangtang-decoction-ameliorate-diabetic-nephropathy-through-the-regulation-of-pi3k-akt-mediated-nf-%C3%AE%C2%BAb-pathways-in-kk-ay-mice
#16
Jin-Ni Hong, Wei-Wei Li, Lin-Lin Wang, Hao Guo, Yong Jiang, Yun-Jia Gao, Peng-Fei Tu, Xue-Mei Wang
BACKGROUND: Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28507058/hepatocyte-nuclear-factor-1%C3%AE-regulates-urinary-concentration-and-response-to-hypertonicity
#17
Karam Aboudehen, Lama Noureddine, Patricia Cobo-Stark, Svetlana Avdulov, Shayan Farahani, Micah D Gearhart, Daniel G Bichet, Marco Pontoglio, Vishal Patel, Peter Igarashi
The transcription factor hepatocyte nuclear factor-1β (HNF-1β) is essential for normal kidney development and function. Inactivation of HNF-1β in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality. Here, we used Pkhd1/Cre mice to delete HNF-1β specifically in renal collecting ducts (CDs). CD-specific HNF-1β mutant mice survived long term and developed slowly progressive cystic kidney disease, renal fibrosis, and hydronephrosis. Compared with wild-type littermates, HNF-1β mutant mice exhibited polyuria and polydipsia...
May 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28506671/modeling-of-flux-binding-and-substitution-of-urea-molecules-in-the-urea-transporter-dvut
#18
Hai-Tian Zhang, Zhe Wang, Tao Yu, Jian-Ping Sang, Xian-Wu Zou, Xiaoqin Zou
Urea transporters (UTs) are transmembrane proteins that transport urea molecules across cell membranes and play a crucial role in urea excretion and water balance. Modeling the functional characteristics of UTs helps us understand how their structures accomplish the functions at the atomic level, and facilitates future therapeutic design targeting the UTs. This study was based on the crystal structure of Desulfovibrio vulgaris urea transporter (dvUT). To model the binding behavior of urea molecules in dvUT, we constructed a cooperative binding model...
April 25, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28503330/febuxostat-attenuates-renal-damage-besides-exerting-hypouricemic-effect-in-streptozotocin-induced-diabetic-rats
#19
Jianmin Ran, Gang Xu, Huixuan Ma, Hailing Xu, Yan Liu, Rongshao Tan, Ping Zhu, Jun Song, Gancheng Lao
Aim. In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. Methods. Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats. Sham-injected rats served as controls. The control and diabetic rats were treated with and without febuxostat for 8 weeks, respectively. Fasting blood and 24-h urine samples were collected every 4 weeks. Rat livers were extracted for detecting gene expression, content, and bioactivity of XO...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28501426/attenuation-of-diabetic-nephropathy-by-sanziguben-granule-inhibiting-emt-through-nrf2-mediated-anti-oxidative-effects-in-streptozotocin-stz-induced-diabetic-rats
#20
Chenxue Zhang, Qian Li, Sisi Lai, Lei Yang, Guoqi Shi, Qing Wang, Zijie Luo, Ruizhi Zhao, Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is an acute and serious diabetic complication characterized by renal hypertrophy and renal fibrosis with the expansion of extracellular matrices. Diabetic nephropathy has become a major cause of end-stage kidney disease. Sanziguben Granule (SZGB) is a compound prescription which has been widely applied in clinical medicine for the prevention and treatment of diabetic nephropathy as well as for acute and chronic kidney injuries...
June 9, 2017: Journal of Ethnopharmacology
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