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https://www.readbyqxmd.com/read/27914710/higher-net-acid-excretion-is-associated-with-a-lower-risk-of-kidney-disease-progression-in-patients-with%C3%A2-diabetes
#1
Julia J Scialla, John Asplin, Mirela Dobre, Alex R Chang, James Lash, Chi-Yuan Hsu, Radhakrishna R Kallem, L Lee Hamm, Harold I Feldman, Jing Chen, Lawrence J Appel, Cheryl A M Anderson, Myles Wolf
Higher diet-dependent nonvolatile acid load is associated with faster chronic kidney disease (CKD) progression, but most studies have used estimated acid load or measured only components of the gold standard, net acid excretion (NAE). Here we measured NAE as the sum of urine ammonium and titratable acidity in 24-hour urines from a random subset of 980 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. In multivariable models accounting for demographics, comorbidity and kidney function, higher NAE was significantly associated with lower serum bicarbonate (0...
November 30, 2016: Kidney International
https://www.readbyqxmd.com/read/27876925/therapeutic-effect-of-arctium-lappa-in-schistosoma-haematobium-associated-kidney-disturbance-biochemical-and-molecular-effects
#2
Khaled M M Koriem, Zulzamri H Idris, Hasniza F Haron, Nurulhuda A Omar, Halita S Lazain
Schistosoma haematobium (S. haematobium) infection has been found to be strongly associated with bladder cancer, which necessitates for discover of a natural new therapeutic agent. The aim of this study was to evaluate the therapeutic effect of Arctium lappa seed extract in S. haematobium associated kidney disturbance. Forty male albino mice were used and divided into four equal groups; group 1 control includes non-infected healthy mice, groups 2, 3 and 4 subcutaneous infected with S. haematobium cercariae...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27875290/whole-body-protein-turnover-and-net-protein-balance-after-pediatric-thoracic-surgery-a-noninvasive-single-dose-15n-glycine-stable-isotope-protocol-with-end-product-enrichment
#3
Brenna S Fullerton, Eric A Sparks, Faraz A Khan, Jeremy G Fisher, Rocco Anzaldi, Michael R Scoville, Yong-Ming Yu, David A Wagner, Tom Jaksic, Nilesh M Mehta
BACKGROUND: We used the (15)N glycine urinary end-product enrichment technique to quantify whole body protein turnover following thoracic surgery. MATERIALS AND METHODS: A single dose of (15)N glycine (2 mg/kg) was administered orally on postoperative day 1 to children (1-18 years) following thoracic surgery. (15)N enrichment of ammonia and urea was measured in mixed urine after 12 and 24 hours, respectively, and protein synthesis, breakdown, and net balance determined...
November 15, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27865300/effect-of-dapagliflozin-treatment-on-fluid-and-electrolyte-balance-in-diabetic-rats
#4
Ling Chen, Lauren M LaRocque, Orhan Efe, Juan Wang, Jeff M Sands, Janet D Klein
AIM: This study evaluates the effect of dapagliflozin, a SGLT2 inhibitor, on fluid or electrolyte balance and its effect on urea transporter-A1 (UT-A1), aquaporin-2 (AQP2) and Na-K-2Cl cotransporter (NKCC2) protein abundance in diabetic rats. METHODS: Diabetes mellitus (DM) was induced by injection of streptozotocin into the tail vein. Serum Na(+), K(+), Cl(-) concentration, urine Na(+), K(+), Cl(-) excretion, blood glucose, urine glucose excretion, urine volume, urine osmolality and urine urea excretion were analyzed after the administration of dapagliflozin...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27860049/pimpinella-anisum-l-ethanolic-extract-ameliorates-the-gentamicin-induced-nephrotoxicity-in-rats
#5
Saeed Changizi-Ashtiyani, Amirhassan Seddigh, Houshang Najafi, Nasser Hossaini, Amir Avan, Ahmad Akbary, Mostafa Manian, Reza Nedaeinia
AIM: Gentamicin (GM) is one of the commonest causes of drug-induced nephrotoxicity. Moreover, oxidative stress plays an important role in gentamicin-induced nephrotoxicity. The current study aimed to explore the anti-oxidant and protective effects of Pimpinella anisum (P. anisum) on the alleviation of GM-induced damage. METHODS: Forty male wistar rats were divided into four groups: control, sham that was administrated normal saline orally and intraperitoneally (i...
November 8, 2016: Nephrology
https://www.readbyqxmd.com/read/27846769/effect-of-cichorium-intybus-l-seed-extract-on-renal-parameters-in-experimentally-induced-early-and-late-diabetes-type-2-in-rats
#6
Yasin Pourfarjam, Lotfollah Rezagholizadeh, Azin Nowrouzi, Alipasha Meysamie, Sarah Ghaseminejad, Nasrin Ziamajidi, Davood Norouzi
Blood and urine biochemistry screening tests are important for initial detection of diabetes, determination of severity of its complications, and monitoring of therapy. We evaluated the effects of aqueous chicory seed extract (CSE), on renal biochemical parameters, histology, and Na+/glucose cotansporters, SGLT1 and SGLT2 expression levels using metformin, and aspirin as controls. Late stage type 2 diabetes (LT2D; FBS, >300 mg/dl) and early stage type 2 diabetes (ET2D; FBS, 140-220 mg/dl) were induced in rats by streptozotocin (STZ group) and a combination of STZ and niacinamide (NIA/STZ group), respectively...
November 16, 2016: Renal Failure
https://www.readbyqxmd.com/read/27830586/effect-of-dietary-quebracho-tannin-extract-on-feed-intake-digestibility-excretion-of-urinary-purine-derivatives-and-milk-production-in-dairy-cows
#7
Anika Henke, Uta Dickhoefer, Edwin Westreicher-Kristen, Karin Knappstein, Joachim Molkentin, Mario Hasler, Andreas Susenbeth
The aim of this study was to evaluate the effects of dietary Quebracho tannin extract (QTE) on feed intake, apparent total tract digestibility (ATTD), excretion of urinary purine derivatives (PD) and milk composition and yield in dairy cows. Fifty Holstein cows were divided into two groups. To reach a similar performance of both groups, cows were divided according to their milk yield, body weight, days in milk and number of lactations at the start of the experiment averaging 33.2 ± 8.2 kg/d, 637 ± 58 kg, 114 ± 73 d and 2...
November 10, 2016: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/27830333/hooded-seal-cystophora-cristata-pups-ingest-snow-and-seawater-during-their-post-weaning-fast
#8
Pauke C Schots, Marie E Bue, Erling S Nordøy
The purpose of this study was to evaluate the importance of exogenous water intake (snow/seawater) in hooded seal (Cystophora cristata) pups during their post-weaning fast. In this study, five hooded seal pups had ad lib access to snow and seawater for the first 12 and last 21 days of their post-weaning fast, respectively. Total body water and water flux were determined during both exposure periods by use of the tritiated water method. Blood samples were collected to monitor changes in hematocrit, plasma urea and plasma osmolality...
November 9, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/27802150/feeding-through-your-gills-and-turning-a-toxicant-into-a-resource-how-the-dogfish-shark-scavenges-ammonia-from-its-environment
#9
Chris M Wood, Marina Giacomin
Nitrogen (N) appears to be a limiting dietary resource for elasmobranchs, required not only for protein growth but also for urea-based osmoregulation. Building on recent evidence that the toxicant ammonia can be taken up actively at the gills of the shark and made into the valuable osmolyte urea, we demonstrate that the uptake exhibits classic Michaelis-Menten saturation kinetics with an affinity constant (Km) of 379 µmol l(-1), resulting in net N retention at environmentally realistic ammonia concentrations (100-400 µmol l(-1)) and net N loss through stimulated urea-N excretion at higher levels...
October 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27782759/zinc-supplementation-alleviates-hyperglycemia-and-associated-metabolic-abnormalities-in-streptozotocin-induced-diabetic-rats
#10
Susmita Barman, Krishnapura Srinivasan
The cause and effect relationship between diabetes and zinc is complex and unclear. This animal study has examined the potential of zinc supplementation in beneficial modulating hyperglycemia, insulin secretion, and metabolic abnormalities associated with diabetes. The study was conducted in streptozotocin-induced diabetic rats. Groups of hyperglycemic rats were subjected to dietary interventions for 6 weeks with zinc supplementation (5 times and 10 times the normal level). Supplemental-zinc-fed diabetic groups showed significant control on hyperglycemia and hypoinsulinemia...
August 7, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27751996/fractional-excretion-of-magnesium-a-marker-of-aminoglycoside-induced-nephrotoxicity-in-neonates
#11
Sheikh Farjana Sonia, Mohammad S Hassan, Ferdous Ara, Mohammed Hanif
Aminoglycoside is a widely used antibiotic in neonatal age group at hospital setting in Bangladesh. It has underlying side effect and toxicity which is mostly unseen and ignored. The aim of the study was to evaluate the nephrotoxic effect of aminoglycoside in neonates. This study was conducted in fifty hospital admitted neonates of Dhaka Shishu Hospital from January 2012 to December 2013. Serum creatinine, blood urea nitrogen, and fractional excretion of magnesium (FEMg) were measured before starting and after seven days of aminoglycoside treatment...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27747195/respiratory-syncytial-virus-aggravates-renal-injury-through-cytokines-and-direct-renal-injury
#12
Songhui Zhai, Lijuan Hu, Lin Zhong, Yannan Guo, Liqun Dong, Ruizhen Jia, Zheng Wang
The purpose of this study was to investigate the relationship between renal injury and reinfection that is caused by respiratory syncytial virus (RSV) and to analyze the mechanism of renal injury. Rats were repeatedly infected with RSV on days 4, 8, 14, and 28, then sacrificed and examined on day 56 after the primary infection. Renal injury was examined by transmission electron microscopy and histopathology. The F protein of RSV was detected in the renal tissue by indirect immunofluorescence. Proteinuria and urinary glycosaminoglycans (GAGs), serum levels of albumin, urea nitrogen, and creatinine, secretion of cytokines, T lymphocyte population and subsets, and dendritic cell (DC) activation state were examined...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27733975/might-e-cadherin-promoter-polymorphisms-of-rs16260-and-rs5030625-associate-with-the-risk-of-nephrolithiasis
#13
Cigdem Donmez, Ece Konac, Batuhan T Aydogan, Cenk Y Bilen
PURPOSE: To study whether -160 C > A (rs16260) and -347 G > GA (rs5030625) single nucleotide polymorphisms of the regulatory region (rSNPs) of CDH1 gene modulate the risk of nephrolithiasis. METHODS: Genomic DNA of 101 patients with calcium oxalate nephrolithiasis and 114 healthy controls were screened for both polymorphisms, using polymerase chain reaction-restriction fragments length polymorphism method (PCR-RLFP). Haplotype frequencies were also analyzed...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27733168/efficacy-of-statins-in-patients-with-diabetic-nephropathy-a-meta-analysis-of-randomized-controlled-trials
#14
Xue Shen, Zhongwen Zhang, Xiaoqian Zhang, Junyu Zhao, Xiaojun Zhou, Qinglei Xu, Hongxia Shang, Jianjun Dong, Lin Liao
BACKGROUND: The effects of statins in patients with diabetic nephropathy are controversial. With increasing interest in the potential therapeutic role of statins in diabetic nephropathy, it is essential to evaluate its real effects. METHODS: PubMed, EMBASE, Web of Science databases, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure were systematically searched for randomized controlled trials (RCTs) of statins in patients with diabetic nephropathy...
October 12, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27724994/combination-of-legume-based-herbage-and-total-mixed-ration-tmr-maintains-intake-and-nutrient-utilization-of-tmr-and-improves-nitrogen-utilization-of-herbage-in-heifers
#15
A Santana, C Cajarville, A Mendoza, J L Repetto
Diets combining herbage and total mixed rations (TMR) are increasingly used in temperate regions for feeding ruminants, but little information is available regarding the effects on nutrient intake and digestion of this feeding management in beef cattle. The aim of this study was to determine the effects of combining TMR (10% CP and 13% ADF), and legume-based herbage (14% CP and 27% ADF) on intake, nutrient digestion, ruminal fermentation, microbial N flow and glucose and nitrogen metabolism in heifers. The experiment was a 3×3 Latin square design replicated three times; each period lasted 18 days (10 adaptation days and 8 measurement days)...
October 11, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27699876/estimating-time-averaged-serum-urea-nitrogen-concentration-during-various-urine-collection-periods-a-prediction-equation-for-thrice-weekly-and-biweekly-dialysis-schedules
#16
John T Daugirdas
Residual kidney urea clearance in dialysis patients typically is calculated as the per minute excretion of urea nitrogen, obtained during the 24-48 hour collection period that usually ends just prior to a dialysis session, divided by the time-averaged serum water urea nitrogen concentration during the collection period. This concentration is difficult to estimate unless a formal kinetic modeling program is being used. We used a urea kinetic modeling program to derive an equation to estimate the time-averaged serum water concentration during urine collection periods of various lengths collected during various interdialytic intervals, for 3/week or 2/week dialysis schedules...
November 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27678172/-13-c-and-15-n-natural-isotope-abundance-reflects-breast-cancer-cell-metabolism
#17
Illa Tea, Estelle Martineau, Ingrid Antheaume, Julie Lalande, Caroline Mauve, Francoise Gilard, Sophie Barillé-Nion, Anneke C Blackburn, Guillaume Tcherkez
Breast cancer is the most common cancer in women worldwide. Despite the information provided by anatomopathological assessment and molecular markers (such as receptor expression ER, PR, HER2), breast cancer therapies and prognostics depend on the metabolic properties of tumor cells. However, metabolomics have not provided a robust and congruent biomarker yet, likely because individual metabolite contents are insufficient to encapsulate all of the alterations in metabolic fluxes. Here, we took advantage of natural (13)C and (15)N isotope abundance to show there are isotopic differences between healthy and cancer biopsy tissues or between healthy and malignant cultured cell lines...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27670393/the-response-to-tolvaptan-and-its-effect-on-prognosis-in-cirrhotic-patients-with-ascites
#18
Tomomi Kogiso, Kuniko Yamamoto, Mutsuki Kobayashi, Yuichi Ikarashi, Kazuhisa Kodama, Makiko Taniai, Nobuyuki Torii, Etsuko Hashimoto, Katsutoshi Tokushige
AIMS: The vasopressin V2 receptor antagonist tolvaptan has been used for the treatment of cirrhotic patients with ascites; however, no predictor of efficacy and prognosis has been developed. Here, we evaluated candidate predictors of response to tolvaptan treatment. METHODS: This was a single-center retrospective study. Overall, 97 Japanese cirrhotic patients (60 males, median age 63 years), who were hospitalized for ascites treatment including oral tolvaptan coupled with conventional diuretics, were enrolled...
September 27, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27624603/the-effect-of-tolvaptan-on-renal-excretion-of-electrolytes-and-urea-nitrogen-in-patients-undergoing-coronary-artery-bypass-surgery
#19
Tomoko S Kato, Hiroshi Nakamura, Mai Murata, Kishio Kuroda, Hitoshi Suzuki, Yasutaka Yokoyama, Akie Shimada, Satoshi Matsushita, Taira Yamamoto, Atsushi Amano
BACKGROUND: Adequate fluid management is an important component of patient care following cardiac surgery. Our aim in this study was to determine the benefits of tolvaptan, an oral selective vasopressin-2 receptor antagonist that causes electrolyte-free water diuresis, in postoperative fluid management. We prospectively examined the effect of tolvaptan on renal excretion of electrolytes and urea nitrogen in cardiac surgery patients. METHODS: Patients undergoing coronary artery bypass surgery were randomized to receive conventional loop diuretics (Group C, n = 30) or conventional loop diuretic therapy plus tolvaptan (Group T, n = 27)...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27608780/identification-and-stratification-of-diabetic-kidney-disease-using-serum-cystatin-c-and-serum-creatinine-based-estimating-equations-in-type-2-diabetes-a-comparative-analysis
#20
S Avinash, V P Singh, A K Agarwal, S Chatterjee, V Arya
BACKGROUND: Cystatin C is a low molecular weight protein produced by all nucleated human cells, with a stable production rate. Its levels are not influenced by inflammation, infections, hepatic or renal diseases, or by dietary or constitutional factors. We compared serum cystatin C and serum creatinine based predicting equations to estimate glomerular filteration rate (GFR) in type 2 diabetes mellitus, using the staging of chronic kidney disease (CKD) defined by the National Kidney Foundation...
November 2015: Journal of the Association of Physicians of India
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