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https://www.readbyqxmd.com/read/29772642/pilot-study-examining-the-influence-of-potassium-bicarbonate-supplementation-on-nitrogen-balance-and-whole-body-ammonia-and-urea-turnover-following-short-term-energy-restriction-in-older-men
#1
Lee M Margolis, Lisa Ceglia, Donato A Rivas, Bess Dawson-Hughes, Roger A Fielding
With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day-1 potassium bicarbonate (KHCO₃) versus a placebo (PLA) on 24-h urinary net acid excretion (NAE), nitrogen balance (NBAL), and whole-body ammonia and urea turnover following short-term diet-induced weight loss. Sixteen (KHCO₃; n = 8, PLA; n = 8) older (64 ± 4 years) overweight (BMI: 28.5 ± 2.1 kg∙day-1 ) men completed a 35-day controlled feeding study, with a 7-day weight-maintenance phase followed by a 28-day 30% energy-restriction phase...
May 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29767729/a-comparative-study-on-the-excretion-of-urinary-metabolites-in-goats-and-sheep-to-evaluate-spot-sampling-applied-to-protein-nutrition-trials
#2
A C S Dos Santos, S A Santos, G G P Carvalho, L D S Mariz, M S L Tosto, S C Valadares Filho, J A G Azevedo
The main objective of this study was to establish a protocol to validate urine spot samples to estimate N excretion and microbial synthesis in goat and sheep; and to study factors that affect daily creatinine and purine derivatives urinary excretion. Also a performance trial was carried out to compare goat and sheep slaughtered after different feedlot periods. Twelve Boer goats (20.6 kg±3.4 initial BW) and twelve Dorper sheep (18.4 kg±2.3 initial BW), all 4-month-old, males, were used. Eight animals (four goats and four sheep) were randomly allocated to be slaughtered at 28, 56 and 84 days in feedlot...
May 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29761900/fenofibrate-improves-renal-function-by-amelioration-of-nox-4-il-18-and-p53-expression-in-an-experimental-model-of-diabetic-nephropathy
#3
Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is no evidence about its effects on interleukin-18 (IL-18), NADPH oxidase type 4 (NOX-4), and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of fenofibrate on improving the underlying mechanisms of diabetic nephropathy...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29753739/effect-of-cisplatin-on-the-clock-genes-expression-in-the-liver-heart-and-kidney
#4
Bei-Bei Cao, Dengfeng Li, Xiaoliang Xing, Yaguang Zhao, Kunyang Wu, Fang Jiang, Wei Yin, Jia-Da Li
Cisplatin is a platinum-based chemotherapy drug is widely used to treat various types of malignancies. Although the involvement of circadian clock in cisplatin metabolism and excretion has been reported, the effect of cisplatin on circadian rhythm remains unclear. In the present study, we investigated the effects of cisplatin on clock genes expression in mouse peripheral tissues. Cisplatin induced severe nephrotoxicity, as revealed by the significant increase of blood urea nitrogen and serum creatinine levels...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29753467/effect-of-exogenous-amylase-on-lactation-performance-of-dairy-cows-fed-a-high-starch-diet
#5
Arturo S R Andreazzi, Marcos N Pereira, Ronaldo B Reis, Renata A N Pereira, Nilson N Morais Júnior, Tiago S Acedo, Rafael G Hermes, Cristina S Cortinhas
Exogenous amylase supplementation can increase starch and fiber digestibility in lactating dairy cows. We evaluated the effect of exogenous amylase supplementation on diets with high starch concentration (32% of dry matter). Twenty-eight Holstein cows (171 ± 80 d in milk, 4 primiparous) received a standard diet for 14 d and then a treatment for 63 d, in a covariate-adjusted randomized block design with repeated measures over time. Treatments were amylase [0.5 g of Ronozyme RumiStar (DSM Nutritional Products, Basel, Switzerland) per kg of total mixed ration dry matter] or control...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29719791/antihyperuricemic-effect-of-mangiferin-aglycon-derivative-j99745-by-inhibiting-xanthine-oxidase-activity-and-urate-transporter-1-expression-in-mice
#6
Zhizhen Qin, Shoubao Wang, Yihuang Lin, Ying Zhao, Shengqian Yang, Junke Song, Tao Xie, Jinlong Tian, Song Wu, Guanhua Du
A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the underlying mechanisms. Mice were orally administered 600 mg/kg xanthine once daily for 7 days and intraperitoneally injected 250 mg/kg oxonic acid on the 7th day to induce hyperuricemia. Meanwhile, J99745 (3, 10, and 30 mg/kg), allopurinol (20 mg/kg) or benzbromarone (20 mg/kg) were orally administered to mice for 7 days...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29710508/puerarin-improves-methotrexate-induced-renal-damage-by-up-regulating-renal-expression-of-oat1-and-oat3-in-vivo-and-in-vitro
#7
Qi Liu, Zhihao Liu, Xiaokui Huo, Changyuan Wang, Qiang Meng, Huijun Sun, Pengyuan Sun, Jinyong Peng, Xiaodong Ma, Kexin Liu
The regulation of renal transporters such as organic anion transporter (OATs) is a new target for treatment of acute renal failure. The purpose of this study was to investigate whether the effect of puerarin (Pur) on renal damage induced by methotrexate (MTX) is related to the expression of renal Oat1/3 in vivo and in vitro, and to explore the related mechanisms. Effect of Pur on the renal damage caused by MTX was evaluated by assessment of the changes of endogenous metabolites, toxins and H&E staining...
April 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29693650/a-randomized-trial-to-study-the-comparative-efficacy-of-phenylbutyrate-and-benzoate-on-nitrogen-excretion-and-ureagenesis-in-healthy-volunteers
#8
Sandesh C S Nagamani, Umang Agarwal, Allison Tam, Mahshid Azamian, Ann McMeans, Inka C Didelija, Mahmoud A Mohammad, Juan C Marini
PurposeBenzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.MethodsWe conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m-2 BSA•day-1 ), benzoate (NaBz; 5.5 g•m-2 BSA•day-1 ), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m-2 BSA•day-1 ) on nitrogen excretion...
October 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29686861/pre-pregnancy-bmi-gestational-weight-gain-and-body-image-are-associated-with-dietary-under-reporting-in-pregnant-japanese-women
#9
Mie Shiraishi, Megumi Haruna, Masayo Matsuzaki, Ryoko Murayama, Satoshi Sasaki
Dietary under-reporting is a common problem when using self-reported dietary assessment tools. However, there are few studies regarding under-reporting during pregnancy. This study aimed to explore the demographic and psychosocial characteristics related to dietary under-reporting in pregnant Japanese women. A cross-sectional study was conducted between 2010 and 2011 at a university hospital in Tokyo, Japan. Nutrient intake was assessed using a self-administered Diet History Questionnaire (DHQ), which had questions about the consumption frequency and portion size of selected food items...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29682583/therapeutic-effects-of-tangshen-formula-on-diabetic-nephropathy-in-db-db-mice-using-cytokine-antibody-array
#10
Xue Mei Fan, Chun Lian Huang, Yi Ming Wang, Ning Li, Qiong Lin Liang, Guo An Luo
Objective: Cytokines are essential promoters in the pathogenesis of diabetic nephropathy (DN) in type 2 diabetes. The following study investigates the adjustment mechanism of Tangshen formula (TSF) on cytokine expressions in db/db mice (DN animal model). Materials and Methods: Db/db mice were randomly divided into three groups. The treated groups were orally administered with TSF and losartan for 12 weeks. Biochemical and histological examinations were determined at 8 and 12 weeks posttreatment, while the cytokine antibody array analysis was applied to analyze the expression of 144 cytokines in kidney tissues at the end of the 12th week posttreatment...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29675795/oral-adsorbent-ast-120-ameliorates-gut-environment-and-protects-against-the-progression-of-renal-impairment-in-ckd-rats
#11
Ayumi Yoshifuji, Shu Wakino, Junichiro Irie, Ayumi Matsui, Kazuhiro Hasegawa, Hirobumi Tokuyama, Koichi Hayashi, Hiroshi Itoh
BACKGROUND: Oral charcoal adsorbent AST-120 (AST) is reported to ameliorate renal dysfunction by the absorption of toxic substance in the gut. Recent study revealed that, in CKD, gut environment is disturbed including the decrease in tight junctions and Lactobacillus (Lact). In this study, we examined whether AST improves the renal dysfunction through gut environment. METHOD: Six-week-old spontaneously hypertensive rats (SHR) were rendered CKD by 5/6th nephrectomy (Nx)...
April 19, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29674265/relationship-between-plasma-levels-of-homocysteine-and-the-related-b-vitamins-in-patients-with-hemodialysis-adequacy-or-inadequacy
#12
En-Ling Yeh, Yi-Chia Huang, Shang-Feng Tsai, Tong-Min Yu, Ming-Ju Wu, Cheng-Hsu Chen
OBJECTIVES: Hemodialysis (HD) with dialysis adequacy could increase the excretion of B vitamins (folate, vitamin B6 , and B12 ) and raise the plasma level of homocysteine. Here we determined the associations of plasma homocysteine with B vitamins in patients with HD adequacy or inadequacy. METHODS: We recruited 68 patients who had received HD treatments (three times a week, 4 h each). Based on the individual's hemogram and quarterly urea reduction rate (Kt/V), patients were pooled into one of the following two groups: the first group with dialysis adequacy (Kt/V > 1...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29671960/renal-potassium-handling-in-carriers-of-the-gly40ser-mutation-of-the-glucagon-receptor-suggests-a-role-for-glucagon-in-potassium-homeostasis
#13
Lise Bankir, Antonio Barbato, Ornella Russo, Gilles Crambert, Roberto Iacone, Nadine Bouby, Ludovica Perna, Pasquale Strazzullo
Plasma potassium concentration (PK ) is tightly regulated. Insulin is known to favor potassium entry into cells. But how potassium leaves the cells later on is not often considered. Previous studies in rats showed that glucagon infusion increased urinary potassium excretion dose-dependently and reversibly. This prompted us to investigate the possible influence of glucagon on potassium handling in humans. We took advantage of the Gly40Ser mutation of the glucagon receptor (GR) that results in a partial loss of function of the GR...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29657939/cisplatin-alters-sodium-excretion-and-renal-clearance-in-rats-gender-and-drug-dose-related
#14
Sima Jilanchi, Ardeshir Talebi, Mehdi Nematbakhsh
Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29657194/association-of-brucellosis-with-renal-tubular-and-glomerular-damage-in-children-in-turkey
#15
Secil Conkar, Muhammed Kosker, Saliha Cevik, Muzeyyen Ay
Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Until now, no studies have been performed on renal tubular disorders in patients with brucellosis. The present study aims to investigate renal tubular disorders in patients with brucellosis. This prospective case-control study includes a total of 31 brucellosis patients (Group 1) and 30 healthy controls (Group 2) matched for age and sex. Renal tubular functions of children who were diagnosed as having brucellosis in outpatient pediatric clinics were evaluated...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29651565/synthesis-and-preclinical-evaluation-of-novel-18-f-labeled-glu-urea-glu-based-psma-inhibitors-for-prostate-cancer-imaging-a-comparison-with-18-f-dcfpyl-and-18-f-psma-1007
#16
Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger, Hans-Jürgen Wester
BACKGROUND: Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific radiolabeled PSMA ligands. To address the continuously growing clinical demand for 18 F-labeled PSMA-probes, we developed two novel Glu-urea-Glu-(EuE)-based inhibitors, EuE-k-18 F-FBOA (1) and EuE-k-β-a-18 F-FPyl (2), both with optimized linker structure and different 18 F-labeled aromatic moieties...
April 12, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29627253/yeast-culture-increased-plasma-niacin-concentration-evaporative-heat-loss-and-feed-efficiency-of-dairy-cows-in-a-hot-environment
#17
Julia D L Dias, Rayana B Silva, Tatiane Fernandes, Eugenio F Barbosa, Larissa E C Graças, Rafael C Araujo, Renata A N Pereira, Marcos N Pereira
The supplementation of dairy cows with yeast culture may increase diet digestibility, plasma niacin concentration, heat dissipation, and lactation performance. Our objective was to evaluate the response of Holstein cows in late lactation (234 ± 131 d in milk) to dead yeast culture (YC, 15 g/d, Factor SC, GRASP, Saccharomyces cerevisiae) during Brazilian summer (temperature-humidity index >68 for 92.2% of the time). Thirty-two cows were individually fed a standard total mixed ration for 14 d and control (CTL) or YC treatments for 35 d, in a covariate adjusted complete randomized block design...
April 4, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29619875/protective-effect-of-gelofusine-against-crgd-sirna-induced-nephrotoxicity-in-mice
#18
Wenjie Liao, Yixin Qin, Lumin Liao, Bohong Cen, Zhuomin Wu, Yuanyi Wei, Zhen Wang, Guoxian Li, Aimin Ji
Based on successful targeting to the αvβ3 integrin of cyclic arginine-glycine-aspartic acid (cRGD), cRGD-conjugated small interfering RNA (siRNA) exhibits tumor targeting and has become a new treatment strategy for solid tumors. However, the nephrotoxicity caused by its renal retention limits its clinical application. Here, we evaluated the protective effect of Gelofusine against cRGD-conjugated siRNA-induced nephrotoxicity in mice. Male Kunming mice (six per group) were either co-injected with Gelofusine and cRGD-siRNA or injected with cRGD-siRNA alone...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29617268/antidiabetic-and-renoprotective-effect-of-anogeissus-acuminata-leaf-extract-on-experimentally-induced-diabetic-nephropathy
#19
Archana M Navale, Archana Paranjape
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Hyperglycemia, oxidative stress, and inflammation are some of the mechanisms involved in renal damage. Anogeissus acuminata (AA) is used in India as an antidiabetic agent and has potent antioxidant activity. However, it has never been evaluated for its effect on diabetic nephropathy. Hence, in the present study we aimed to evaluate its effect on streptozotocin-induced diabetes mellitus and its renal complications...
April 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29604500/physiological-impacts-and-bioaccumulation-of-dietary-cu-and-cd-in-a-model-teleost-the-amazonian-tambaqui-colossoma-macropomum
#20
Marina Giacomin, Gisele C Vilarinho, Katia F Castro, Márcio Ferreira, Rafael M Duarte, Chris M Wood, Adalberto L Val
Increasing anthropogenic activities in the Amazon have led to elevated metals in the aquatic environment. Since fish are the main source of animal protein for the Amazonian population, understanding metal bioaccumulation patterns and physiological impacts is of critical importance. Juvenile tambaqui, a local model species, were exposed to chronic dietary Cu (essential, 500 μg Cu/g food) and Cd (non-essential, 500 μg Cd/g food). Fish were sampled at 10-14, 18-20 and 33-36 days of exposure and the following parameters were analyzed: growth, voluntary food consumption, conversion efficiency, tissue-specific metal bioaccumulation, ammonia and urea-N excretion, O2 consumption, Pcrit , hypoxia tolerance, nitrogen quotient, major blood plasma ions and metabolites, gill and gut enzyme activities, and in vitro gut fluid transport...
March 19, 2018: Aquatic Toxicology
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