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https://www.readbyqxmd.com/read/29233642/acute-inescapable-stress-alleviates-fear-extinction-recall-deficits-caused-by-serotonin-transporter-abolishment
#1
Pieter Schipper, Marloes J A G Henckens, Dora Lopresto, Tamas Kozicz, Judith R Homberg
Life stress increases risk for developing post-traumatic stress disorder (PTSD), and more prominently so in short-allele carriers of the serotonin transporter linked polymorphic region (5-HTTLPR). Serotonin transporter knockout (5-HTT-/-) rats show compromised extinction (recall) of conditioned fear, which might mediate the increased risk for PTSD and reduce the therapeutic efficacy of exposure therapy. Here, we assessed whether acute inescapable stress (IS) differentially affects fear extinction and extinction recall in 5-HTT-/- rats and wildtype controls...
December 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29231773/molecular-imaging-of-autism-spectrum-disorder
#2
Brian Jaeho Hwang, Mona Adel Mohamed, James Robert Brašić
Autism spectrum disorder (ASD) is a condition with onset in early childhood characterized by marked deficits in interpersonal interactions and communication and by a restricted and repetitive range of interests and activities. This review points out key recent findings utilizing molecular imaging including magnetic resonance spectroscopy (MRS) and nuclear neuroimaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). MRS indicates an excitatory/inhibitory imbalance in high-functioning autism...
December 12, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/29231507/-effect-of-acupuncture-treatment-on-gene-expression-of-neurotransmitters-of-brain-tissue-in-rats-with-post-stroke-depression
#3
Wei Xiao, Xianbao Zhang, Zhen Wang, Yan Wang, Xiaoli Guo, Ling He, Fajun Liang, Huixing Hu
OBJECTIVE: To observe the effects of acupuncture on mRNA of the neurotransmitter serotonin transporter (5-HTT), 5-HT1Areceptor (5-HT1AR), norepinephrineα2 receptor (NEα2R) in brain tissue in rats with post-stroke depression. METHODS: Forty male SD rats were randomly divided into a normal group, a model group, a medication group and an acupuncture group, 10 rats in each one. The model of post-stroke depression was established by occlusion of middle cerebral artery and chronic unpredictable mild stress method...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230168/a-novel-dopamine-transporter-inhibitor-ce-123-improves-cognitive-flexibility-and-maintains-impulsivity-in-healthy-male-rats
#4
Agnieszka Nikiforuk, Predrag Kalaba, Marija Ilic, Volker Korz, Vladimir Dragačević, Judith Wackerlig, Thierry Langer, Harald Höger, Joanna Golebiowska, Piotr Popik, Gert Lubec
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter (DAT) are widely used for their potential to enhance cognitive abilities. However, commercially available drugs are of limited specificity for DAT, blocking also noradrenaline and serotonine transporters, that can lead to unwanted side effects in healthy subjects...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29228944/effect-of-acupuncture-on-lipopolysaccharide-induced-anxiety-like-behavioral-changes-involvement-of-serotonin-system-in-dorsal-raphe-nucleus
#5
Tae Young Yang, Eun Young Jang, Yeonhee Ryu, Gyu Won Lee, Eun Byeol Lee, Suchan Chang, Jong Han Lee, Jin Suk Koo, Chae Ha Yang, Hee Young Kim
BACKGROUND: Acupuncture has been used as a common therapeutic tool in many disorders including anxiety and depression. Serotonin transporter (SERT) plays an important role in the pathology of anxiety and other mood disorders. The aim of this study was to evaluate the effects of acupuncture on lipopolysaccharide (LPS)-induced anxiety-like behaviors and SERT in the dorsal raphe nuclei (DRN). METHODS: Rats were given acupuncture at ST41 (Jiexi), LI11 (Quchi) or SI3 (Houxi) acupoint in LPS-treated rats...
December 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29228731/impact-of-anger-emotional-stress-before-pregnancy-on-adult-male-offspring
#6
Sheng Wei, Xinyang Xiao, Jieqiong Wang, Shiguang Sun, Zifa Li, Kaiyong Xu, Fang Li, Jie Gao, Dehao Zhu, Mingqi Qiao
Previous studies have reported that maternal chronic stress or depression is linked to an increased risk of affective disorders in progeny. However, the impact of maternal chronic stress before pregnancy on the progeny of animal models is unknown. We investigated the behaviors and the neurobiology of 60-day-old male offspring of female rats subjected to 21 days of resident-intruder stress before pregnancy. An anger stressed parental rat model was established using the resident-intruder paradigm and it was evaluated using behavioral tests...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29225192/effects-of-the-new-psychoactive-substances-diclofensine-diphenidine-and-methoxphenidine-on-monoaminergic-systems
#7
Dino Luethi, Marius C Hoener, Matthias E Liechti
Diclofensine, diphenidine, and methoxphenidine are new psychoactive substances (NPSs) that recently appeared on the illicit drug market. Pharmacological profiling of such newly emerged drugs is crucial for a better understanding of their psychotropic effects and toxicity. We therefore investigated the potential of these NPSs to inhibit the norepinephrine, dopamine, and serotonin transporters in human embryonic kidney cells stably transfected with the respective transporters. In addition, we determined monoamine transporter and receptor affinities for the substances...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29223391/effects-of-a-hydroethanolic-extract-of-boophone-disticha-bulb-on-anxiety-related-behaviour-in-naive-balb-c-mice
#8
William Pote, Shamiso Musarira, Donald Chuma, Louis L Gadaga, Ellen Mwandiringana, Dexter Tagwireyi
ETHNOPHARMACOLOGICAL RELEVANCE: Boophone disticha is one of the most important medicinal bulbs of Southern Africa. Previous in vitro studies have shown that it's crude ethanolic extracts and some alkaloidal phytoconstituents possesses high affinity for the serotonin transporter protein (SERT) and serotonin receptor 1a (5HT1a) which are both implicated in the pathogenesis and treatment of anxiety disorders. However, there are no in vivo studies that validates the anxiolytic actions of the plant...
December 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29220746/testing-bidirectional-relationships-between-alcohol-use-and-depressive-symptoms-what-is-the-role-of-the-serotonin-transporter-gene
#9
Roy Otten, Carmen S van der Zwaluw, Rutger C Engels
Alcohol abuse often co-exists with a major depressive disorder. In order to understand the development of this comorbidity, it is important to concentrate on the preceding process. It has been suggested that the link between alcohol use and depressive symptoms is a result of an interaction with genetic factors. The aim of this study was to longitudinally examine the effect of the 5-HTTLPR genotype on the association between depressive symptoms and alcohol use in a Dutch community sample. Following a stepwise approach, bivariate correlations, longitudinal regression analyses, and latent growth curve analyses were separately conducted for 316 males and 321 females...
August 13, 2017: Alcohol
https://www.readbyqxmd.com/read/29216407/an-open-label-positron-emission-tomography-pet-study-to-evaluate-serotonin-transporter-occupancy-following-escalating-dosing-regimens-of-r-o-desmethylvenlafaxine-and-racemic-o-desmethylvenlafaxine
#10
W Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran
INTRODUCTION: SEP-227162 [R(-)-O-desmethylvenlafaxine] is an enantiomer of the venlafaxine metabolite O-desmethylvenlafaxine (ODV, Pristiq™, Wyeth). This study compared the serotonin transporter occupancy achieved by SEP-227162 and ODV, at daily doses of 25mg, 50mg, 100mg and 150mg using [11 C]DASB positron emission tomography (PET). METHODS: Sixteen healthy male subjects participated in one of four dose groups (N = 4 per group) during which they were administered two doses of the study drug (SEP-227162 or ODV)...
December 7, 2017: Synapse
https://www.readbyqxmd.com/read/29210327/5-httlpr-polymorphism-is-associated-with-nostalgia-proneness-the-role-of-neuroticism
#11
Yu L L Luo, Baldwin Way, Keith Welker, C Nathan DeWall, Brad J Bushman, Tim Wildschut, Constantine Sedikides
Nostalgia, a sentimental longing for the past, is a self-relevant and social emotion. Nostalgia proneness is associated with alleviation of distress or instability (e.g., neuroticism). Although nostalgia proneness is heritable, the specific molecular contributors to this heritability are unknown. We focused on a polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) as a possible biological basis of nostalgia proneness, because the serotonin system has been associated with sensitivity to negative experience...
December 6, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/29210107/higher-serotonin-transporter-availability-in-early-onset-obsessive-compulsive-disorder-patients-undergoing-escitalopram-treatment-a-11-c-dasb-pet-study
#12
Junhee Lee, Bo-Hyung Kim, Euitae Kim, Oliver D Howes, Kang Ik Kevin Cho, Youngwoo Bryan Yoon, Jun Soo Kwon
OBJECTIVE: Early-onset obsessive-compulsive disorder (EOCD) and late-onset obsessive-compulsive disorder (LOCD) are distinct subtypes of obsessive-compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet. METHODS: Six EOCD and 6 LOCD patients were enrolled. They underwent serial [11 C]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan...
December 6, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/29202512/a-simple-and-rapid-uplc-pda-method-for-quality-control-of-nardostachys-jatamansi
#13
Weize Zhang, Guo Nan, Hong-Hua Wu, Miaomiao Jiang, Tian-Xiang Li, Meng Wang, Xiu-Mei Gao, Yan Zhu, Yun Seon Song, Jiaming Wang, Yan-Tong Xu
Nardostachys jatamansi is a well-documented herbal agent used to treat digestive and neuropsychiatric disorders in oriental medicinal systems. However, few simple, rapid, and comprehensive methods were reported for quality assessment and control of N. jatamansi. Herein, a UPLC with photodiode array detection method was developed for both fingerprint investigation of N. jatamansi and simultaneous quantitative analysis of the six serotonin transporter modulatory constituents in N. jatamansi. For chromatographic fingerprinting, 24 common peaks were selected as characteristic peaks to assess the consistency of N...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29196338/proteomics-and-metabolomics-identify-molecular-mechanisms-of-aging-potentially-predisposing-for-chronic-lymphocytic-leukemia
#14
Rupert Laurenz Mayer, Josef D Schwarzmeier, Marlene C Gerner, Andrea Bileck, Johanna C Mader, Samuel M Meier-Menches, Samuel M Gerner, Klaus G Schmetterer, Tobias Pukrop, Albrecht Reichle, Astrid Slany, Christopher Gerner
B cell chronic lymphocytic leukemia (B-CLL), the most common type of leukemia in adults, is still essentially incurable despite the development of novel therapeutic strategies. This reflects the incomplete understanding of the pathophysiology of this disease. A comprehensive proteome analysis of primary human B-CLL cells and B cells from younger as well as elderly healthy donors was performed. For comparison, also the chronic B cell leukemia cell line JVM-13 was included. A principal component analysis comprising 6945 proteins separated these four groups, placing B cells of aged-matched controls between those of young donors and B-CLL patients, while identifying JVM-13 as poorly related cells...
December 1, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29195124/corrigendum-to-the-external-gate-of-the-human-and-drosophila-serotonin-transporters-requires-a-basic-acidic-amino-acid-pair-for-3-4-methylenedioxymethamphetamine-mdma-translocation-and-the-induction-of-substrate-efflux-biochem-pharmacol-120-2016-46-55
#15
Natalie R Sealover, Bruce Felts, Charles P Kuntz, Rachel E Jarrard, Gregory H Hockerman, Patrick W Lamb, Eric L Barker, L Keith Henry
No abstract text is available yet for this article.
November 28, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29189941/vortioxetine-clinical-pharmacokinetics-and-drug-interactions
#16
REVIEW
Grace Chen, Astrid-Maria Højer, Johan Areberg, George Nomikos
Vortioxetine is a novel antidepressant with multimodal activity currently approved for the treatment of major depressive disorder. Vortioxetine is orally administered once daily at 5- to 20-mg doses. The pharmacokinetics of vortioxetine are linear and dose proportional, with a mean terminal half-life of approximately 66 h and steady-state plasma concentrations generally achieved within 2 weeks of dosing. The mean absolute oral bioavailability of vortioxetine is 75%. No food effect on pharmacokinetics was observed...
November 30, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29184054/meta-analysis-of-the-interaction-between-serotonin-transporter-promoter-variant-stress-and-posttraumatic-stress-disorder
#17
Mingzhe Zhao, Jiarun Yang, Wenbo Wang, Jingsong Ma, Jian Zhang, Xueyan Zhao, Xiaohui Qiu, Xiuxian Yang, Zhengxue Qiao, Xuejia Song, Lin Wang, Shixiang Jiang, Erying Zhao, Yanjie Yang
Exposure to stress predicts the occurrence of posttraumatic stress disorder (PTSD) in individuals harboring the serotonin transporter promoter variant 5-HTTLPR. We carried out a meta-analysis of studies investigating the interaction between 5-HTTLPR, stress, and PTSD to clarify the interrelatedness of these factors. We reviewed all relevant studies published in English before May 2016. The Lipták-Stouffer z-score method for meta-analysis was applied to combined data. The z score was separately calculated for the stressful life events, childhood adversity, bi- and triallelic loci, and cross-sectional and longitudinal studies subgroups...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29182616/marble-burying-as-compulsive-behaviors-in-male-and-female-mice
#18
George T Taylor, Sandra Lerch, Sabine Chourbaji
Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor or a "pure" inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/29174865/deep-brain-stimulation-induces-antidepressant-like-effects-in-serotonin-transporter-knockout-mice
#19
Tatiana Bregman, Christina Nona, Julien Volle, Mustansir Diwan, Roger Raymond, Paul J Fletcher, José N Nobrega, Clement Hamani
BACKGROUND: Some of the antidepressant-like effects of ventromedial prefrontal cortex (vmPFC) deep brain stimulation (DBS) in rodents have been attributed to the modulation of prefrontal-raphe pathways. This is largely different from selective serotonin reuptake inhibitors (SSRIs), which increase serotonin (5-HT) levels by inhibiting the serotonin transporter (SERT). SSRIs have limited efficacy when given to SERT knockout (KO) mice, or patients with mutations in the serotonin transporter promoter gene (5-HTTLPR)...
November 15, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29174607/upregulation-of-sert-and-adora1-in-broilers-with-acute-right-ventricular-failure
#20
Mohammad Kamely, Mohammad Amir Karimi Torshizi, Robert F Wideman, James West
Pulmonary hypertension (PH), remains a challenging disease with a large impact on both humans and meat-type chickens. PH is characterized by the onset of idiopathic pulmonary arterial hypertension leading to right ventricular failure. In this experiment relative gene expression of adenosine A1 receptor (ADORA1), serotonin transporter (SERT), phosphodiesterase 5A (PDE5) and troponin T2 were compared in hearts from broilers with acute right ventricular failure and from healthy birds. There were major increases in adenosine A1 receptor (177%) and serotonin transporter (475%), and more modest but significant increases in PDE5 (146%) and troponin T2 (140%) gene expressions in broilers with right ventricular failure compared to healthy birds (P<0...
October 5, 2017: Research in Veterinary Science
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