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https://www.readbyqxmd.com/read/28068779/norepinephrine-transporter-gene-variants-and-remission-from-depression-with-venlafaxine-treatment-in-older-adults
#1
Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Müller
OBJECTIVE: The primary objective of this study was to investigate five putatively functional variants of the norepinephrine transporter (SLC6A2, NET) and serotonin transporter (SLC6A4, SERT) genes and remission in depressed older adults treated with venlafaxine. A secondary objective was to analyze 17 other variants in serotonergic system genes (HTR1A, HTR2A, HTR1B, HTR2C, TPH1, TPH2) potentially involved in the mechanism of action of venlafaxine. METHOD: The sample included 350 adults age 60 or older with DSM-IV-defined major depressive disorder and a score of at least 15 on the Montgomery-Åsberg Depression Rating Scale (MADRS)...
January 10, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28064281/childhood-abuse-history-in-depression-predicts-better-response-to-antidepressants-with-higher-serotonin-transporter-affinity-a-pilot-investigation
#2
Lena C Quilty, Victoria Marshe, Daniela S S Lobo, Kate L Harkness, Daniel J Müller, R Michael Bagby
OBJECTIVES: Childhood abuse is a powerful prognostic indicator in adults with major depressive disorder (MDD) and is associated with numerous biological risk factors for depression. The purpose of this investigation was to explore if antidepressant medication affinity for the serotonin transporter moderates the association between childhood abuse and treatment response. METHODS: Our sample included 52 outpatients with MDD who had received up to 26 weeks of pharmacotherapy, stratifying antidepressant medications with a high versus a low affinity for the serotonin transporter...
January 7, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28054193/personality-as-an-intermediate-phenotype-for-genetic-dissection-of-alcohol-use-disorder
#3
REVIEW
Lars Oreland, Gianvito Lagravinese, Simone Toffoletto, Kent W Nilsson, Jaanus Harro, C Robert Cloninger, Erika Comasco
Genetic and environmental interactive influences on predisposition to develop alcohol use disorder (AUD) account for the high heterogeneity among AUD patients and make research on the risk and resiliency factors complicated. Several attempts have been made to identify the genetic basis of AUD; however, only few genetic polymorphisms have consistently been associated with AUD. Intermediate phenotypes are expected to be in-between proxies of basic neuronal biological processes and nosological symptoms of AUD...
January 4, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28043073/a-comparative-qsar-analysis-and-molecular-docking-studies-of-phenyl-piperidine-derivatives-as-potent-dual-nk1r-antagonists-serotonin-transporter-sert-inhibitors
#4
Somayeh Zare, Masood Fereidoonnezhad, Davoud Afshar, Zahra Ramezani
Depression is a critical mood disorder that affects millions of patients. Available therapeutic antidepressant agents are associated with several undesirable side effects. Recently, it has been shown that Neurokinin 1 receptor (NK1R) antagonists can potentiate the antidepressant effects of serotonin-selective reuptake inhibitors (SSRIs). In this study, a series of phenyl piperidine derivatives as potent dual NK1R antagonists/serotonin transporter (SERT) inhibitors were applied to quantitative structure-activity relationship (QSAR) analysis...
December 23, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28035393/fluoxetine-protects-against-methamphetamine%C3%A2-induced-lung-inflammation-by-suppressing-oxidative-stress-through-the-sert-p38-mapk-nrf2-pathway-in-rats
#5
Yun Wang, Yu-Han Gu, Ming Liu, Yang Bai, Huai-Liang Wang
Methamphetamine (MA) abuse is a major public health and safety concern throughout the world and a growing burden on healthcare costs. The purpose of the present study was to investigate the protective effect of fluoxetine against MA‑induced chronic pulmonary inflammation and to evaluate the potential role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidative stress. Wistar rats were divided into control, MA and two fluoxetine‑treated groups. Rats in the MA and the two fluoxetine‑treated groups were treated daily with intraperitoneal injection of 10 mg/kg MA twice daily...
December 23, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28029428/the-serotonin-transporter-gene-5-httlpr-polymorphism-is-associated-with-affective-psychoses-but-not-with-schizophrenia-a-large-scale-study-in-the-russian-population
#6
Vera Golimbet, Galina Korovaitseva, Tatyana Lezheiko, L I Abramova, V G Kaleda
BACKGROUND: Affective syndrome is thought to be a key feature that differentiates schizophrenia from schizoaffective disorder (SA) and bipolar disorder with psychotic features (BDP). However genetic underpinnings of these differences remain unresolved. OBJECTIVES: We compared clinical variables of affective psychoses (SA, BDP and schizophrenia with affective symptoms (AFF SCZ)) and schizophrenia without affective symptoms (non-AFF SCZ) and searched for a genetic variant that may differentiate affective psychosis from non-AFF SCZ...
October 26, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28024274/heterogeneity-in-hpa-axis-dysregulation-and-serotonergic-vulnerability-to-depression
#7
Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Ryan
Variability in the serotonin transporter (5-HTTLPR) gene can influence the risk of depression associated with adversity, as well as cortisol stress reactivity, although not consistently. No study has examined the impact of both a stressful environment and corticotropic-axis dysfunction on depression, as a function of 5-HTTLPR. This population-based study included 334 subjects aged 65 and older. Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures...
December 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28019672/serotonin-transporter-in-parkinson-s-disease-a-meta-analysis-of-pet-studies
#8
REVIEW
Gennaro Pagano, Flavia Niccolini, Paolo Fusar-Poli, Marios Politis
Positron emission tomography (PET) is a powerful analytical tool for the in vivo molecular imaging of the human brain. Over the past years, a number of PET studies imaging the serotonin transporter (SERT) have been employed, and provided evidence for the key role of serotonergic pathology in patients with Parkinson's disease (PD). Here, we review the role of SERT in the development of motor and non-motor complications in patients with PD, and we performed a meta-analysis to identify the patterns of SERT pathology and the relevance to symptoms...
December 26, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27998510/stress-burnout-and-depression-a-systematic-review-on-dna-methylation-mechanisms
#9
REVIEW
Jelena Bakusic, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Despite that burnout presents a serious burden for modern society, there are no diagnostic criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there is a need to dispose of a burnout biomarker. Epigenetic studies suggest that DNA methylation is a possible mediator linking individual response to stress and psychopathology and could be considered as a potential biomarker of stress-related mental disorders. Thus, the aim of this review is to provide an overview of DNA methylation mechanisms in stress, burnout and depression...
January 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27996982/-vortioxetine-in-the-treatment-of-major-depression
#10
Andrea de Bartolomeis, Andrea Fagiolini, Giuseppe Maina
Notwithstanding the high prevalence, functional burden, negative consequences and risk of chronicity of major depressive disorder, few innovative medications have been developed in recent years for the treatment of this heterogeneous disease. Vortioxetine is a multi-modal antidepressant that functions both as serotonin transporter (SERT) inhibitor and as 5-HT3, 5-HT7 and 5-HT1D receptors antagonist, 5-HT1A receptor agonist and 5-HT1B receptor partial agonist. A recent meta-analysis of 11 randomized, double-blind, placebo controlled, acute (6-8 weeks) treatment studies has demonstrated the efficacy of vortioxetine 5-20 mg/day in the treatment of depression, with an increasing effect associated with increasing dose...
November 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27992891/negative-experiences-in-childhood-and-the-development-and-course-of-bipolar-disorder
#11
REVIEW
Paulina Jaworska-Andryszewska, Janusz Rybakowski
The aim of this paper is to review the effects of negative childhood experiences on the development and course of bipolar disorder (BD) and to discuss the involved mechanisms. The negative childhood experiences that may play a role in BD are critical or traumatic events including all kinds of abuse, loss of a parent or parents resulting from death, suicide, separation, divorce or prolonged separation. Previous studies indicate that in BD patients negative childhood events are more frequent than in control group...
October 31, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27989490/paraphilic-sexual-offenders-do-not-differ-from-control-subjects-with-respect-to-dopamine-and-serotonin-related-genetic-polymorphisms
#12
Andrzej Jakubczyk, Aleksandra Krasowska, Marcin Bugaj, Maciej Kopera, Anna Klimkiewicz, Agata Łoczewska, Aneta Michalska, Aleksandra Majewska, Natalia Szejko, Anna Podgórska, Małgorzata Sołowiej, Leszek Markuszewski, Sławomir Jakima, Rafał Płoski, Kirk Brower, Marcin Wojnar
INTRODUCTION: Rape and pedophilic child molestation are the most commonly convicted sexual offenses in Poland. Recent studies have suggested a possible genetic contribution toward pathologic sexual interests and behaviors. AIM: To analyze and compare functional polymorphisms of genes associated with the activity of the serotonin and dopamine systems in a group of paraphilic sexual offenders and control subjects. METHODS: The study sample (n = 97) consisted of two groups: paraphilic sexual offenders (65 pedophilic child molesters and 32 rapists) and controls (n = 76)...
December 15, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27981188/maternal-immune-activation-epigenetically-regulates-hippocampal-serotonin-transporter-levels
#13
Sonali N Reisinger, Eryan Kong, Deeba Khan, Stefan Schulz, Marianne Ronovsky, Stefanie Berger, Orsolya Horvath, Maureen Cabatic, Angelika Berger, Daniela D Pollak
Major depressive disorder (MDD) is one of the most debilitating psychiatric diseases, affecting a large percentage of the population worldwide. Currently, the underlying pathomechanisms remain incompletely understood, hampering the development of critically needed alternative therapeutic strategies, which further largely depends on the availability of suitable model systems. Here we used a mouse model of early life stress - a precipitating factor for the development of MDD - featuring infectious stress through maternal immune activation (MIA) by polyinosinic:polycytidilic acid (Poly(I:C)) to examine epigenetic modulations as potential molecular correlates of the alterations in brain structure, function and behavior...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27964944/resequencing-three-candidate-genes-discovers-seven-potentially-deleterious-variants-susceptibility-to-major-depressive-disorder-and-suicide-attempts-in-chinese
#14
Shitao Rao, Cherry She Ting Leung, Macro Hb Lam, Yun Kwok Wing, Mary Miu Yee Waye, Stephen Kwok Wing Tsui
BACKGROUND: To date almost 200 genes were found to be associated with major depressive disorder (MDD) or suicide attempts (SA), but very few genes were reported for their molecular mechanisms. This study aimed to find out whether there were common or rare variants in three candidate genes altering the risk for MDD and SA in Chinese. METHODS: Three candidate genes (HOMER1, SLC6A4 and TEF) were chosen for resequencing analysis and association studies as they were reported to be involved in the etiology of MDD and SA...
March 1, 2017: Gene
https://www.readbyqxmd.com/read/27959497/inhibition-of-the-serotonin-transporter-is-altered-by-metabolites-of-selective-serotonin-and-norepinephrine-reuptake-inhibitors-and-represents-a-caution-to-acute-or-chronic-treatment-paradigms
#15
Danielle Krout, Meghan Rodriquez, Stephen A Brose, Mikhail Y Golovko, L Keith Henry, Brent J Thompson
Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT. However, the ability of AD metabolites to antagonize SERT was not assessed. Here, we evaluated the selectivity and potency of these metabolites for inhibition of SERT in mouse brain-derived synaptosomes and blood platelets from wild-type (I172 mSERT) and the antidepressant-insensitive mouse M172 mSERT...
December 28, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27958222/effects-of-ginseng-fruit-saponins-on-serotonin-system-in-sprague-dawley-rats-with-myocardial-infarction-depression-and-myocardial-infarction-complicated-with-depression
#16
Dong-Fang He, Yan-Ping Ren, Mei-Yan Liu
BACKGROUND: Our previous studies have demonstrated that the levels of 5-hydroxytryptamine (5-HT) and 5-HT 2A receptor (5-HT2AR) in serum and platelet were associated with depression and myocardial infarction (MI), and pretreatment with ginseng fruit saponins (GFS) before MI and depression had an effect on the 5-HT system. In this study, the effects of GFS on the 5-HT system in the Sprague-Dawley (SD) rats with MI, depression, and MI + depression were evaluated. METHODS: A total of eighty SD rats were allocated to four groups: MI, depression, MI + depression, and control groups (n = 20 in each group)...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27957784/d-cycloserine-enhanced-extinction-of-cocaine-induced-conditioned-place-preference-is-attenuated-in-serotonin-transporter-knockout-rats
#17
Peter Karel, Francesca Calabrese, Marco Riva, Paola Brivio, Bas Van der Veen, Liesbeth Reneman, Michel Verheij, Judith Homberg
d-Cycloserine (DCS), a partial NMDA receptor agonist, has been proposed as a cognitive enhancer to facilitate the extinction of drug-related memories. However, it is unknown whether there are individual differences in the efficacy of DCS. Here, we set out to investigate the influence of serotonin transporter (5-HTT) genotype on DCS treatment outcome and the underlying neural mechanism. To that end, we first determined the mRNA levels of several NMDA receptor subunits and observed a reduction in NR1/NR2C receptors in the ventromedial prefrontal cortex and nucleus accumbens of 5-HTT(-/-) compared with 5-HTT(+/+) rats...
December 12, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27956753/the-serotonin-transporter-promoter-variant-stress-and-attentional-biases-in-middle-childhood
#18
Yuliya Kotelnikova, Joelle LeMoult, Sarah V M Mackrell, Haroon I Sheikh, Shiva M Singh, Jutta Joormann, Ian H Gotlib, Elizabeth P Hayden
Although evidence suggests that 5-HTTLPR variants may shape risk for depression, the influence is likely complex, and involves effects on endophenotypes. We examined associations between 5-HTTLPR and biases in attention to affective stimuli in a sample of girls and a sample of both boys and girls. Children with at least one short (S) variant of the 5-HTTLPR polymorphism had lower positive attentional bias scores in both samples. This association was qualified by an interaction with stress in one sample, such that links between the S allele and decreased positive attentional bias was significant only when life stress was elevated...
September 2016: Personality and Individual Differences
https://www.readbyqxmd.com/read/27942217/association-between-serotonin-transporter-gene-polymorphisms-and-heroin-dependence-a-meta-analytic-study
#19
Pao-Yen Lin, Yi-Shan Wu
BACKGROUND: Studies have examined the association between heroin dependence and serotonin transporter gene polymorphisms but yielded inconsistent results. The purpose of current study is to determine the overall effect of these polymorphisms on the risk for heroin dependence through a meta-analytic method. METHODS: A meta-analysis was conducted to examine the association of heroin dependence with two common polymorphisms of serotonin transporter gene, in the promoter (5-hydroxytryptamine transporter-linked promotor region [5-httlpr]) and intron 2 (a various number tandem repeat in serotonin transporter intron 2 [STin2])...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27941910/effects-of-dextromethorphan-on-mdma-induced-serotonergic-aberration-in-the-brains-of-non-human-primates-using-123-i-adam-spect
#20
Kuo-Hsing Ma, Tsung-Ta Liu, Shao-Ju Weng, Chien-Fu F Chen, Yuahn-Sieh Huang, Sheau-Huei Chueh, Mei-Hsiu Liao, Kang-Wei Chang, Chi-Chang Sung, Te-Hung Hsu, Wen-Sheng Huang, Cheng-Yi Cheng
3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely used antitussive reported to exert anti-inflammatory effect in vivo. In this study, we examined the long-term effect of MDMA on the primate serotonergic system and the protective property of DM against MDMA-induced serotonergic abnormality using single photon emission computed tomography (SPECT). Nine monkeys (Macaca cyclopis) were divided into three groups, namely control, MDMA and co-treatment (MDMA/DM)...
December 12, 2016: Scientific Reports
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