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https://www.readbyqxmd.com/read/29350657/an-icet-a-survey-on-hypoparathyroidism-in-patients-with-thalassaemia-major-and-intermedia-a-preliminary-report
#1
Vincenzo De Sanctis, Ashraf T Soliman, Duran Canatan, Heba Elsedfy, Mehran Karimi, Shahina Daar, Hala Rimawi, Soteroula Christou, Nicos Skordis, Ploutarchos Tzoulis, Praveen Sobti, Shruti Kakkar, Yurdanur Kilinc, Doaa Khater, Saif A Alyaarubi, Valeriya Kaleva, Su Han Lum, Mohamed A Yassin, Forough Saki, Maha Obiedat, Salvatore Anastasi, Maria Concetta Galati, Giuseppe Raiola, Saveria Campisi, Nada Soliman, Mohamed Elshinawy, Soad Al Jaouni, Salvatore Di Maio, Yasser Wali, Ihab Zaki Elhakim, Christos Kattamis
Hypoparathyroidism (HPT) is a rare disease with leading symptoms of hypocalcemia, associated with high serum phosphorus levels and absent or inappropriately low levels of parathyroid hormone (PTH). In patients with thalassemias it is mainly attributed to transfusional iron overload, and suboptimal iron chelation therapy. The main objectives of this survey were to provide data on the prevalence, demographic and clinical features of HPT in thalassemia major (TM) and intermedia (TI) patients living in different countries, and to assess its impact in clinical medical practice...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29349485/undiagnosed-primary-hyperparathyroidism-and-recurrent-miscarriage-the-first-prospective-pilot-study
#2
Aimee DiMarco, Ioannis Christakis, Vasilis Constantinides, Lesley Regan, F Fausto Palazzo
BACKGROUND: Primary hyperparathyroidism (pHPT) in pregnancy is reported to be associated with significant maternal and foetal complications and an up to threefold increase in the risk of miscarriage. However, the true incidence of pHPT in pregnancy, complete and miscarried, is unknown and there are no data on the prevalence of undiagnosed pHPT in recurrent miscarriage (RM) (≥3 consecutive miscarriages under 24-week gestation). This is the first prospective study aiming to establish the prevalence of undiagnosed pHPT in RM...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29348466/gender-specific-association-of-parathyroid-hormone-and-vitamin-d-with-metabolic-syndrome-in-population-with-preserved-renal-function
#3
Min-Hee Kim, Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Bong Yun Cha
The association of parathyroid hormone (PTH) and vitamin D with Metabolic syndrome (MetS) was evaluated using representative data from the Korean population. Data from 7004 subjects aged 50 or older with preserved renal function (excluding chronic kidney disease stage 3b to 5) who were included in the Korean National Health and Nutrition Examination Survey between 2008 and 2010 were analysed. Higher PTH levels (pg/ml) were observed in subjects with MetS than in those without MetS among both genders (60.1 (58...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342867/a-longitudinal-study-of-25-hydroxy-vitamin-d-and-parathyroid-hormone-status-throughout-pregnancy-and-exclusive-lactation-in-new-zealand-mothers-and-their-infants-at-45%C3%A2-s
#4
Benjamin J Wheeler, Barry J Taylor, Michel de Lange, Michelle J Harper, Shirley Jones, Adel Mekhail, Lisa A Houghton
Vitamin D status and associated metabolism during pregnancy and lactation have been assessed in only a limited number of longitudinal studies, all from the northern hemisphere, with no infant data concurrently reported. Therefore, we aimed to describe longitudinal maternal and infant 25-hydroxy vitamin D (25OHD) and parathyroid hormone (PTH) status during pregnancy and up to 5 months postnatal age, in New Zealand women and their infants living at 45° S latitude. Between September 2011 and June 2013, 126 pregnant women intending to exclusively breastfeed for at least 20 weeks were recruited...
January 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29336900/combined-use-of-a-nanocarbon-suspension-and-99mtc-mibi-for-the-intra-operative-localization-of-the-parathyroid-glands
#5
Jun Chen, Qinyi Zhou, Jialin Feng, Jiadong Wang
OBJECTIVE: To investigate the combined use of a nanocarbon (NC) suspension and low-dose 99mTc-MIBI for parathyroid localization during surgery in patients with secondary hyperparathyroidism (sHPT). METHODS: Between March 2010 and September 2015, 40 patients with sHPT were enrolled in this study and were randomized to receive either low-dose 99mTc-MIBI+NC (group I) or low-dose 99mTc-MIBI (group II). Pre- and post-operative serum levels of intact PTH (iPTH), calcium and phosphorus between groups were compared and the intra-operative radioactive counts of the parathyroid glands were measured...
December 13, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29336756/risk-factors-for-elevated-preoperative-alkaline-phosphatase-in-patients-with-refractory-secondary-hyperparathyroidism
#6
Meng Yang, Ling Zhang, Linping Huang, Xiaoliang Sun, Haoyang Ji, Yao Lu
Elevated preoperative levels of alkaline phosphatase (ALP) in patients with refractory secondary hyperparathyroidism are correlated with postoperative hypocalcemia and mortality. The aim of this study was to identify the predictors of preoperative ALP in patients with secondary hyperparathyroidism. From April 2012 to December 2015, 220 patients with refractory secondary hyperparathyroidism undergoing total parathyroidectomy without autotransplantation were reviewed. A total of 164 patients presented with elevated preoperative ALP...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29336547/efficient-blue-and-yellow-organic-light-emitting-diodes-enabled-by-aggregation-induced-emission
#7
N Venkatramaiah, G Dinesh Kumar, Yogesh Chandrasekaran, Ramesh Ganduri, Satish Patil
A new class of donor-bridge-acceptor (D-π-A) π-conjugated light-emitting molecules comprising carbazole as donor and maleimide (Cbz-MI, Cbz-MI(d)), phthalimide (Cbz-Pth) as acceptor units with phenyl ring as spacer have been synthesized in good yields. These compounds exhibit high quantum yield with three distinct emission colors yellowish-green (Cbz-MI), bright yellow Cbz-MI(d), and sky blue (Cbz-Pth) in the solid state. Single-crystal X-ray and quantum chemical calculations reveals that twisting of the phenyl rings with high torsional angle on maleimide and phthalimide units reduce the effective inter-chromophore electronic coupling, furnish dramatic changes in their photophysical properties in solution and solid states...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336002/body-composition-and-circulating-estradiol-are-the-main-bone-density-predictors-in-healthy-young-and-middle-aged-men
#8
S C Bilha, D Branisteanu, C Buzduga, D Constantinescu, P Cianga, E Anisie, A Covic, M C Ungureanu
PURPOSE: Current fracture risk assessment options in men call for improved evaluation strategies. Recent research directed towards non-classic bone mass determinants have often yielded scarce and conflicting results. We aimed at investigating the impact of novel potential bone mass regulators together with classic determinants of bone status in healthy young and middle-aged men. METHODS: Anthropometric measurements, all-site bone mineral density (BMD) and body composition parameters assessed by dual-energy X-ray absorptiometry and also serum concentrations of (1) the adipokines leptin and resistin, (2) vitamin D and parathormone (PTH), (3) sex hormone binding globulin (SHBG), total testosterone and estradiol (free testosterone was also calculated) and (4) C-terminal telopeptide of type I collagen (CTx) were obtained from 30 apparently healthy male volunteers aged 20-65 years enrolled in this cross-sectional study...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29331397/persistent-hyperparathyroidism-as-a-risk-factor-for-long-term-graft-failure-the-need-to-discuss-indication-for-parathyroidectomy
#9
Maria Júlia Correia Lima Nepomuceno Araujo, Janaina Almeida Mota Ramalho, Rosilene Motta Elias, Vanda Jorgetti, William Nahas, Melani Custodio, Rosa M A Moysés, Elias David-Neto
BACKGROUND: Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29330344/parathyroid-hormone-related-protein-exhibits-antioxidant-features-in-osteoblastic-cells-through-its-n-terminal-and-osteostatin-domains
#10
S Portal-Núñez, J A Ardura, D Lozano, I Martínez de Toda, M De la Fuente, G Herrero-Beaumont, R Largo, P Esbrit
OBJECTIVES: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts. The PTH counterpart in bone, which is the PTH-related protein (PTHrP), displays osteogenic actions through both its N-terminal PTH-like region and the C-terminal domain...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29330338/diagnosis-management-histology-and-genetics-of-sporadic-primary-hyperparathyroidism-old-knowledge-with-new-tricks
#11
Maria Mizamtsidi, Constantinos Nastos, George Mastorakos, Roberto Dina, Ioannis Vassiliou, Maria Gazouli, Fausto Palazzo
Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Elucidation of the genetic background of each of these clinical entities would be of great interest...
January 12, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29324909/effect-of-hypoparathyroid-on-bone-mineral-density-of-lumber-spine-in-postmenopausal-women-with-differentiated-thyroid-cancinoma
#12
Yongli Bai, Yanlei Huo, Fei Yu, Danyang Wang, Chao Ma
OBJECTIVE: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC). SUBJECT AND METHODS: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Bone mineral density (BMD) at the lumbar spine was analyzed using dual-energy X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29322026/the-pgris-and-parathyroid-splinting-concepts-for-the-analysis-and-prognosis-of-protracted-hypoparathyroidism
#13
Antonio Sitges-Serra
Most patients with hypocalcemia after total thyroidectomy will recover the parathyroid function in a few weeks, but some 20-30% of them will still be in the need for replacement therapy one month after surgery and about 5-10% of those will develop permanent hypoparathyroidism. Although postoperative hypocalcemia has been related to several demographic and metabolic causes, parathyroid hormone (PTH) decline, resulting from autotransplantation, inadvertent excision or devascularization of the parathyroid glands, is the common final pathway...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29322021/the-role-and-timing-of-parathyroid-hormone-determination-after-total-thyroidectomy
#14
REVIEW
Ioanna G Mazotas, Tracy S Wang
Postoperative hypocalcemia is a common complication of total thyroidectomy resulting from manipulation, resection, or devascularization of the parathyroid glands. Parathyroid hormone (PTH) levels assessed in the perioperative period have been used to predict development of hypocalcemia. Articles examining the role of PTH measurement in the perioperative period following total or completion thyroidectomy are reviewed. Focus is placed on the timing of PTH measurement and the ability to predict which patients will develop hypocalcemia requiring supplementation...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29322018/a-nomogram-to-predict-the-likelihood-of-permanent-hypoparathyroidism-after-total-thyroidectomy-based-on-delayed-serum-calcium-and-ipth-measurements
#15
Antonio Sitges-Serra, Joaquín Gómez, Marcin Barczynski, Leyre Lorente-Poch, Maurizio Iacobone, Juan Sancho
Background: Retrospective studies have shown that delayed high-normal serum calcium and detectable iPTH are independent variables positively influencing outcome of prolonged parathyroid failure after total thyroidectomy (TT). The aim of the present study was to examine prospectively the ability of these two variables to predict permanent hypoparathyroidism in patients under replacement therapy for postoperative hypocalcemia. Methods: Prospective observational multicenter study of patients undergoing TT followed by postoperative parathyroid failure (serum calcium <8 mg/dL within 24 h and PTH <15 pg/mL 4 h after surgery)...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29317405/coagulation-and-fibrinolysis-in-hyperparathyroidism-secondary-to-vitamin-d-deficiency
#16
Laura P B Elbers, Marije Wijnberge, Joost C M Meijers, Dennis C W Poland, Dees P M Brandjes, Eric Fliers, Victor E A Gerdes
INTRODUCTION: Abnormal coagulation tests have been observed in patients with primary hyperparathyroidism (HPT) suggesting a prothrombotic effect of parathyroid hormone (PTH). Vitamin D deficiency (VIDD) is the most frequent cause of secondary HPT. Aim of our study was to investigate the influence of HPT secondary to moderate-severe VIDD and vitamin D replacement on the coagulation and fibrinolysis system. SUBJECTS AND METHODS: Prospective cohort study of patients with vitamin D<25 nmol/l with and without HPT, and a control group of patients on vitamin D suppletion...
January 9, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29315610/magnetic-dispersive-solid-phase-extraction-based-on-graphene-oxide-fe3-o4-polythionine-nanocomposite-followed-by-atomic-absorption-spectrometry-for-zinc-monitoring-in-water-flour-celery-and-egg
#17
Azar Babaei, Mohsen Zeeb, Ali Es-Haghi
BACKGROUND: Magnetic graphene oxide nanocomposite has been proposed as promising and sustainable sorbent for the extraction and separation of target analytes from food matrices. Sample preparation based on nanocomposite presents several advantages such as desired efficiency, reasonable selectivity and high surface area-to-volume ratio. RESULTS: A new graphene oxide/Fe3 O4 @polythionine (GO/Fe3 O4 @PTh) nanocomposite sorbent was introduced for magnetic dispersive solid-phase extraction (MDSPE) and flame atomic absorption spectrometric (FAAS) detection of zinc (II) in water, flour, celery and egg...
January 9, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29312648/predicting-clinically-significant-prostate-cancer-based-on-pre-operative-patient-profile-and-serum-biomarkers
#18
Izak Faiena, Sinae Kim, Nicholas Farber, Young Suk Kwon, Brian Shinder, Neal Patel, Amirali H Salmasi, Thomas Jang, Eric A Singer, Wun-Jae Kim, Isaac Y Kim
Previous studies have reported association of multiple preoperative factors predicting clinically significant prostate cancer with varying results. We assessed the predictive model using a combination of hormone profile, serum biomarkers, and patient characteristics in order to improve the accuracy of risk stratification of patients with prostate cancer. Data on 224 patients from our prostatectomy database were queried. Demographic characteristics, including age, body mass index (BMI), clinical stage, clinical Gleason score (GS) as well as serum biomarkers, such as prostate-specific antigen (PSA), parathyroid hormone (PTH), calcium (Ca), prostate acid phosphatase (PAP), testosterone, and chromogranin A (CgA), were used to build a predictive model of clinically significant prostate cancer using logistic regression methods...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310503/decision-making-for-position-dependent-obstructive-sleep-apnea-syndrome-on-the-basis-of-patient-information-and-physical-examinations-of-the-upper-airway-acquired-on-an-outpatient-basis
#19
Minoru Endo, Takahito Kondo, Rie Shimada, Kiyoaki Tsukahara
CONCLUSIONS: Patients with body mass index (BMI) < 25 kg/m2 and obstructive sleep apnea syndrome (OSAS) are highly suspicious for position-dependent OSAS. Diagnosis of position-dependent/position-independent OSAS can be difficult in patients satisfying both 'BMI >25 kg/m2' and 'any of tongue enlargement (TE), palatine tonsil hypertrophy (PTH) and obstruction by Muller's maneuver (OMM)'. Polysomnography is warranted in such patients. OBJECTIVES: The objective was to retrospectively elucidate criteria for differentiating position-dependent OSAS on the basis of patient information and physical examinations of the upper airway obtainable in clinics...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29306227/parathyroid-hormone-in-washout-fluid-seems-to-be-superior-to-cytology-for-localization-of-the-lesion-in-mibi-negative-patients-with-primary-hyperparathyroidism
#20
Güven Barış Cansu, Bengür Taşkıran, Hayrettin Dizen, Betül Peker Cengiz
Background/aim: Primary hyperparathyroidism (PHPT) is characterized by increased calcium (Ca) and parathyroid hormone (PTH) levels. Surgical removal of the culprit hyperfunctioning parathyroid gland is the preferred treatment. In this study, we aimed to determine whether PTH-washout or cytological examination of suspicious lesions was superior in MIBI-negative patients diagnosed with PHPT.Materials and methods: We retrospectively evaluated the medical records of 98 patients diagnosed with PHPT. Seventy-six patients who had positive parathyroid scintigraphy and who did not undergo parathyroidectomy in our center due to various reasons were excluded...
December 19, 2017: Turkish Journal of Medical Sciences
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