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https://www.readbyqxmd.com/read/29775856/a-simple-ultrasensitive-electrochemical-sensor-for-simultaneous-determination-of-gallic-acid-and-uric-acid-in-human-urine-and-fruit-juices-based-on-zirconia-choline-chloride-gold-nanoparticles-modified-carbon-paste-electrode
#1
Seyed Alireza Shahamirifard, Mehrorang Ghaedi, Zahra Razmi, Shaaker Hajati
The determination of gallic acid (GA) and uric acid (UA) is essential due to their biological properties. Numerous methods have been reported for the analysis of GA and UA in various real samples. However, the development of a simple, rapid and practical sensor still remains a great challenge. Here, a carbon paste electrode (CPE) was modified by nanocomposite containing zirconia nanoparticles (ZrO2 NPs), Choline chloride (ChCl) and gold nanoparticles (AuNPs) to construct ZrO2 -ChCl-AuNPs/CPE as electrochemical sensor for the simultaneous electro-oxidation of GA and UA...
May 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29775834/association-between-food-insecurity-and-food-intake
#2
Melissa Luciana de Araújo, Raquel de Deus Mendonça, José Divino Lopes Filho, Aline Cristine Souza Lopes
BACKGROUND: We aim to identify the prevalence of food insecurity and to ascertain the association between food insecurity and food intake. METHOD: A cross-sectional survey. SETTING: The study included users of a primary healthcare service in Belo Horizonte, Brazil, from 2013 to 2014. Socioeconomic, health, and food intake data were gathered using a questionnaire and the Brazilian Food Insecurity Scale. SUBJECTS: Individuals 20 years old or older (n = 2817)...
March 28, 2018: Nutrition
https://www.readbyqxmd.com/read/29775541/molecular-characterization-and-bioactivity-of-coumarin-derivatives-from-the-fruits-of-cucumis-bisexualis
#3
Qin-Ge Ma, Rong-Rui Wei, Ming Yang, Xiao-Ying Huang, Fang Wang, Zhi-Pei Sang, Wen-Min Liu, Qing Yu
Cucumis bisexualis (Cucurbitaceae) is known as "mapao egg" or "muskmelon egg", which has been widely used as a wild melon in Chinese folk. Nine new coumarin derivatives (1-9), named 7-hydroxy-3-(4',6'-dihydroxy-5'-isopropyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (1), 7-hydroxy-3-(5'-prenyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (2), 3-(6'-hydroxy-5'-prenyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (3), 3-(5'-ethyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (4), 3-(4',6'-dihydroxy-5'-dimethylallyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (5), 3-[4',6'-dihydroxy-5'-(2-propenyl)-3'',3''-dimethyl-2H-chromen]-14,15-dimethyl-pyrano-chromen-2-one (6), 3-(6'-dihydroxy-5'-isopropanol-3'',3''-dimethyl-2H-chromen)-14,15-dimethyl-pyrano-chromen-2-one (7), 3-(5'-isopentenol-3'',3''-dimethyl-2H-chromen)-14,15-dimethyl-pyrano-chromen-2-one (8), 3-(4',6'-dihydroxy-5'-prenyl-3'',3''-dimethyl-2H-chromen)-14,15-dimethyl-pyrano-chromen-2-one (9), together with twelve known compounds (10-21), were isolated and identified by spectroscopic analysis and references from the active site (EtOAc soluble fraction) of the fruits of C...
May 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29774854/marburg-virus-infection-in-egyptian-rousette-bats-south-africa-2013-2014-1
#4
Janusz T Pawęska, Petrus Jansen van Vuren, Alan Kemp, Nadia Storm, Antoinette A Grobbelaar, Michael R Wiley, Gustavo Palacios, Wanda Markotter
We detected a high seroprevalence of Marburg virus (MARV) antibodies in fruit bats in South Africa; 19.1% of recaptured bats seroconverted. The MARV RNA isolated closely resembled the 1975 Ozolin strain. These findings indicate endemic MARV circulation in bats in South Africa and should inform policies on MARV disease risk reduction.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774351/diversity-of-biologically-active-secondary-metabolites-from-endophytic-and-saprotrophic-fungi-of-the-ascomycete-order-xylariales
#5
REVIEW
Soleiman E Helaly, Benjarong Thongbai, Marc Stadler
Covering: up to December 2017The diversity of secondary metabolites in the fungal order Xylariales is reviewed with special emphasis on correlations between chemical diversity and biodiversity as inferred from recent taxonomic and phylogenetic studies. The Xylariales are arguably among the predominant fungal endophytes, which are the producer organisms of pharmaceutical lead compounds including the antimycotic sordarins and the antiparasitic nodulisporic acids, as well as the marketed drug, emodepside. Many Xylariales are "macromycetes", which form conspicuous fruiting bodies (stromata), and the metabolite profiles that are predominant in the stromata are often complementary to those encountered in corresponding mycelial cultures of a given species...
May 18, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/29774047/genome-sequencing-and-analysis-of-the-peanut-b-genome-progenitor-arachis-ipaensis
#6
Qing Lu, Haifen Li, Yanbin Hong, Guoqiang Zhang, Shijie Wen, Xingyu Li, Guiyuan Zhou, Shaoxiong Li, Hao Liu, Haiyan Liu, Zhongjian Liu, Rajeev K Varshney, Xiaoping Chen, Xuanqiang Liang
Peanut ( Arachis hypogaea L.), an important leguminous crop, is widely cultivated in tropical and subtropical regions. Peanut is an allotetraploid, having A and B subgenomes that maybe have originated in its diploid progenitors Arachis duranensis (A-genome) and Arachis ipaensis (B-genome), respectively. We previously sequenced the former and here present the draft genome of the latter, expanding our knowledge of the unique biology of Arachis . The assembled genome of A. ipaensis is ~1.39 Gb with 39,704 predicted protein-encoding genes...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29773477/selenium-bioaccumulation-and-associated-nutraceutical-properties-in-calocybe-indica-mushroom-cultivated-on-se-enriched-wheat-straw
#7
Himanshi Rathore, Abhishek Sharma, Shalinee Prasad, Satyawati Sharma
Calocybe indica was cultivated on wheat straw enriched with various concentrations of sodium selenite (Na2 SeO3 ), (2.5-40 μg/ml). The content of selenium (Se) in fruit bodies increased linearly by increasing the amount of Na2 SeO3 , although the biomass yield inhibited above 5 μg/ml. The fruit bodies accumulated inorganic Se into organic forms by integrating the Se into proteins (56%-68%), polysaccharides (22%-29%), and nucleic acids (1.4%-2.7%). Maximum protein content (25.31 g/100 g) was observed in fruit bodies harvested from the substrate enriched with 10 μg/ml Se...
May 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29773393/comparative-study-of-physicochemical-properties-and-bioactivity-of-hericium-erinaceus-polysaccharides-at-different-solvent-extractions
#8
Jing-Kun Yan, Zhi-Chao Ding, Xianli Gao, Yao-Yao Wang, Yan Yang, Di Wu, He-Nan Zhang
In this study, hot water, 0.9% NaCl, citric acid, and 1.25 M NaOH/0.05% NaBH4 were separately used for the extraction of water-soluble H. erinaceus polysaccharides (HEPs; HEP-W, HEP-S, HEP-C, and HEP-A) from the fruit body of Hericium erinaceus. The physicochemical properties and biological activities were then investigated and compared. Results showed that the extraction solvents exhibited significant effects on the extraction yields, molecular weights, monosaccharide compositions, preliminary structural characteristics, microstructures of HEPs and on their contents, such as neutral sugar, uronic acid, protein, and β-(1 → 3)-glucan...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773188/the-toxic-effect-of-gallic-acid-on-biochemical-factors-viability-and-proliferation-of-rat-bone-marrow-mesenchymal-stem-cells-was-compensated-by-boric-acid
#9
Mohammad Hussein Abnosi, Somayeh Yari
OBJECTIVE: Gallic acid (GA) and boron are found in many plants. Our previous studies showed 6 ng/ml boric acid (BA) had positive effect on biochemistry of rat bone marrow mesenchymal stem cells (MSCs) and their osteogenic differentiation. Therefore, we investigate the effect of different doses of GA alone and in the presence of BA on MSCs. MATERIALS AND METHODS: the viability of MSCs was assayed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue at 12, 24 and 36 h in presence of different concentration of GA...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773006/antimelanogenesis-and-anti-inflammatory-activity-of-selected-culinary-medicinal-mushrooms
#10
Hazwani Mat Saad, Kae Shin Sim, Yee Shin Tan
Five culinary-medicinal mushrooms are commonly available in the Malaysian market: Agaricus bisporus (white and brown), Ganoderma lucidum, Hypsizygus marmoreus, Pleurotus floridanus, and P. pulmonarius. These species were selected for use in the current study, the aim of which was to investigate the antimelanogenesis and anti-inflammatory activity of these mushrooms in an attempt to evaluate their potential use in cosmeceuticals. Mushroom fruiting bodies were extracted with hot water, and the extracts were freeze-dried before testing...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29773004/anti-inflammatory-activity-of-chemical-constituents-isolated-from-the-willow-bracket-medicinal-mushroom-phellinus-igniarius-agaricomycetes
#11
Zhe Jiang, Mei Jin, Wei Zhou, Ren Li, Yan Zhao, Xuejun Jin, Gao Li
Nuclear factor-κB (NF-κB) has an important role in immune response and inflammation. Phellinus igniarius (known as Sang huang in traditional Chinese medicine) has various pharmacologic effects. In this study, 19 chemical constituents (1-19) were isolated from the fruiting bodies of Ph. igniarius. Their structures were elucidated based on data from nuclear magnetic resonance spectroscopy and comparison with the literature. Overall, 3 compounds (2, 7, and 11) from this species were reported, to our knowledge for the first time...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772800/identification-and-expression-of-mirnas-related-to-female-flower-induction-in-walnut-juglans-regia-l
#12
Li Zhou, Shaowen Quan, Hang Xu, Li Ma, Jianxin Niu
Flower induction is an essential stage in walnut ( Juglans regia L.) trees, directly affecting yield, yield stability, fruit quality and commodity value. The objective of this study was to identify miRNAs related to female flower induction via high-throughput sequencing and bioinformatics analysis. A total of 123 miRNAs were identified including 51 known miRNAs and 72 novel miRNAs. Differential expression was observed in 19 of the known miRNAs and 34 of the novel miRNAs. Twelve miRNAs were confirmed by RT-qPCR...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29772776/pyrrole-alkaloids-from-the-edible-mushroom-phlebopus-portentosus-with-their-bioactive-activities
#13
Zhaocui Sun, Meigeng Hu, Zhonghao Sun, Nailiang Zhu, Junshan Yang, Guoxu Ma, Xudong Xu
Seven pyrrole alkaloids, three of which are novel (phlebopines A⁻C ( 1 ⁻ 3 )), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus . Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound 7 displayed remarkable neuroprotective effects against hydrogen peroxide (H₂O₂)-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29772757/fine-mapping-and-candidate-gene-prediction-for-white-immature-fruit-skin-in-cucumber-cucumis-sativus-l
#14
Hong-Yu Tang, Xu Dong, Jian-Ke Wang, Jun-Hui Xia, Fei Xie, Yu Zhang, Xuan Yao, Yue-Jin Xu, Zheng-Jie Wang
In this study, a single recessive gene (designated w ₀) was identified to control the white immature fruit color. Genetic mapping with simple sequence repeats (SSR) markers located the w₀ gene in the distal region of cucumber chromosome 3 (Chr.3). Fine mapping was then conducted using the method of draft genome scaffold-assisted chromosome walking with 7304 F₂ individuals, which allowed for the assignment of the gene locus to a 100.3 kb genomic DNA region with two flanking markers, Q138 and Q193. Thirteen candidate genes were predicted in the 100...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772703/alpha-mangostin-improves-insulin-secretion-and-protects-ins-1-cells-from-streptozotocin-induced-damage
#15
Dahae Lee, Young-Mi Kim, Kiwon Jung, Young-Won Chin, Ki Sung Kang
Alpha (α)-mangostin, a yellow crystalline powder with a xanthone core structure, is isolated from mangosteen ( Garcinia mangostana ), which is a tropical fruit of great nutritional value. The aim of the present study was to investigate the anti-diabetic effects of α-mangostin and to elucidate the molecular mechanisms underlying its effect on pancreatic beta (β)-cell dysfunction. To assess the effects of α-mangostin on insulin production, rat pancreatic INS-1 cells were treated with non-toxic doses of α-mangostin (1⁻10 μM) and its impact on insulin signaling was examined by Western blotting...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772647/the-antimicrobial-activity-of-annona-emarginata-schltdl-h-rainer-and-most-active-isolated-compounds-against-clinically-important-bacteria
#16
Juan G Dolab, Beatriz Lima, Ewelina Spaczynska, Jiri Kos, Natividad H Cano, Gabriela Feresin, Alejandro Tapia, Francisco Garibotto, Elisa Petenatti, Monica Olivella, Robert Musiol, Josef Jampilek, Ricardo D Enriz
Annona emarginata (Schltdl.) H. Rainer, commonly known as "arachichú", "araticú", "aratigú", and "yerba mora", is a plant that grows in Argentina. Infusions and decoctions are used in folk medicine as a gargle against throat pain and for calming toothache; another way to use the plant for these purposes is chewing its leaves. Extracts from bark, flowers, leaves, and fruits from A. emarginata were subjected to antibacterial assays against a panel of Gram (+) and Gram (-) pathogenic bacteria according to Clinical and Laboratory Standards Institute protocols...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29772515/simultaneous-determination-of-nine-neonicotinoids-in-human-urine-using-isotope-dilution-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#17
Quan Zhang, Ximing Wang, Zhe Li, Hangbiao Jin, Zhengbiao Lu, Chang Yu, Yu-Fang Huang, Meirong Zhao
Neonicotinoids (neonics), a class of systemic insecticides, have been frequently detected in pollen, vegetables, and fruits. Recently, an increasing concern has been aroused for human exposure to neonics. However, biological monitoring for quantifying body burden of neonics has rarely been reported. In this study, we developed an isotope-dilution ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method to simultaneously quantify nine neonics, including acetamiprid (ACE), thiamethoxam (THIAM), imidacloprid (IMIP), clothianidin (CLO), flonicamid (FLO), thiacloprid (THIAC), dinotefuran (DIN), nitenpyram (NIT), and imidaclothiz (IMIT) in urine...
May 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29772410/estrogenic-properties-of-coumarins-and-meroterpene-from-the-fruits-of-cullen-corylifolium-experimental-and-computational-studies
#18
Tiehua Zhang, Shuning Zhong, Ligang Hou, Tiezhu Li, XiaoJia Xing, Tianzhu Guan, Jie Zhang, Yongjun Wang
Coumarins and meroterpene from the fruits of Cullen corylifolium were evaluated for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro studies and molecular dynamics simulations. The recombinant hERα ligand binding domain (hERα-LBD) was produced in BL21 (DE3)pLysS and the fluorescence polarization (FP) assay was performed to determine the binding affinities of coumarins and meroterpene with receptor protein. These compounds displayed distinct binding potency toward hERα-LBD, generally increased with their increasing molecular length and Connolly solvent-excluded volume (CSEV)...
May 14, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29772299/biophenols-enzymes-%C3%AE-secretase-cholinesterases-histone-deacetylase-and-tyrosinase-inhibitors-from-olive-olea-europaea-l
#19
Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obied
The focus of this study was on inhibition of enzymes involved in the pathogenesis Alzheimer's disease (AD) including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols. Here we report the strongest inhibition of BACE-1 from rutin (IC50 : 3.8 nM) followed by verbascoside (IC50 : 6.3 nM) and olive fruit extract (IC50 : 18 ng), respectively...
May 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29771736/the-role-of-diet-for-prevention-and-management-of-hypertension
#20
Cemal Ozemek, Deepika R Laddu, Ross Arena, Carl J Lavie
PURPOSE OF REVIEW: Regular consumption of a diet high in sodium, energy dense foods, fat content, refined carbohydrates, added sugar and low in fruits and vegetables contributes to an increased risk of developing hypertension (HTN) and cardiovascular disease. This review aims to provide a synopsis of evidence-based dietary approaches that have been effective in lowering blood pressure (BP) in pre-HTN and individuals with HTN. RECENT FINDINGS: Recent dietary recommendations have emphasized overall dietary patterns and its relation between food and BP...
May 15, 2018: Current Opinion in Cardiology
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