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https://www.readbyqxmd.com/read/29775760/synthesis-of-axially-disubstituted-silicon-phthalocyanines-and-investigation-of-photodynamic-effects-on-hct-116-colorectal-cancer-cell-line
#1
Ceren Sarı, Figen Celep Eyüpoğlu, İsmail Değirmencioğlu, Rıza Bayrak
Photodynamic therapy is one of the hot topics in cancer studies recently. Basically, photosensitizing chemical substrates which are stimulated by light having a specific wavelength cause fatal effect on different kind of cells in photodynamic therapy. In this study, axially 4-{[(1E)-2-furylmethylene]amino}phenol, 4-{[(1E)-2-thienylmethylene]amino}phenol and 4-{[(1E)-(4-nitro-2-thienyl)methylene]amino}phenol disubstituted silicon phthalocyanines were synthesized as Photosensitizers for photodynamic therapy in cancer treatment for the first time...
May 15, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29764120/multi-arm-nanoconjugates-for-cancer-cell-targeted-delivery-of-photosensitizers
#2
Yan Zhao, Fang Li, Chengqiong Mao, Xin Ming
Photodynamic therapy, a procedure that uses a photosensitizer to enable light therapy selectively at diseased sites, remains underutilized in oncological clinic. To further improve its cancer selectivity, we developed a polymeric nanosystem by conjugating a photosensitizer IRDye 700DX (IR700) and cancer targeting RGD peptide to 8-arm polyethylene glycol (PEG). The resulting nanoconjugates (RGD-8PEG-IR700) exhibited a hydrodynamic size of 6.6 nm with narrow distribution of size. The targeted nanoconjugates showed significantly higher intracellular uptake of IR700 in integrin αvβ3-expressing A375 and SKOV3 cells when compared with non-targeted control 8PEG-IR700, and excess amount of RGD peptides could abolish this enhancement, indicating a receptor-medicated uptake mechanism for the targeted polymer conjugates...
May 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29755464/oncolytic-viral-therapy-and-the-immune-system-a-double-edged-sword-against-cancer
#3
REVIEW
Giulia Marelli, Anwen Howells, Nicholas R Lemoine, Yaohe Wang
Oncolytic viral therapy is a new promising strategy against cancer. Oncolytic viruses (OVs) can replicate in cancer cells but not in normal cells, leading to lysis of the tumor mass. Beside this primary effect, OVs can also stimulate the immune system. Tumors are an immuno-suppressive environment in which the immune system is silenced in order to avoid the immune response against cancer cells. The delivery of OVs into the tumor wakes up the immune system so that it can facilitate a strong and durable response against the tumor itself...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29750281/an-orthotopic-glioblastoma-animal-model-suitable-for-high-throughput-screenings
#4
Linda Pudelko, Steven Edwards, Mirela Balan, Daniel Nyqvist, Jonathan Al-Saadi, Johannes Dittmer, Ingrid Almlöf, Thomas Helleday, Lars Bräutigam
Background: Glioblastoma (GBM) is an aggressive form of brain cancer with poor prognosis. Although murine animal models have given valuable insights into the GBM disease biology, they cannot be used in high-throughput screens to identify and profile novel therapies. The only vertebrate model suitable for large-scale screens, the zebrafish, has proven to faithfully recapitulate biology and pathology of human malignancies and clinically relevant orthotopic zebrafish models have been developed...
May 10, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29749554/enhanced-production-of-reactive-oxygen-species-in-hela-cells-under-concurrent-low%C3%A2-dose-carboplatin-and-photofrin%C3%A2-photodynamic-therapy
#5
Younshick Choi, Ji-Eun Chang, Sanghoon Jheon, Sei-Jun Han, Jong-Ki Kim
Concurrent low‑dose carboplatin/Photofrin® photodynamic therapy (ccPDT) has been shown to promote relapse‑free complete tumor regression in cervical or endometrial cancer patients as a fertility‑preservation therapy. This study aimed to investigate the molecular mechanism of the enhanced therapeutic efficacy of ccPDT by determining intracellular reactive oxygen species (ROS) and necrotic or apoptotic cell damage in HeLa cells loaded with fluorescent oxidant agents and Photofrin or/and carboplatin under light irradiation...
May 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29748234/radioiodine-therapy-in-differentiated-thyroid-cancer-a-matter-of-controversy-pro-radioiodine
#6
Matthias Schmidt, Rainer Görges, Alexander Drzezga, Markus Dietlein
Radioiodine therapy is a matter of controversy as different opinions exist towards its use in patients with differentiated thyroid carcinoma. The following article sheds light on different opinions and explains why the authors advocate the use of radioiodine therapy not only in high-risk patients. In comparison to other malignancies differentiated thyroid carcinoma has a different tumor biology due to its usually slow growth pattern. Radioiodine therapy was first used about 75 years ago and provided cure at a time when prospective randomized controlled trials were to be developed...
May 10, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29747146/verteporfin-mediated-sequence-dependent-combination-therapy-against-ovarian-cancer-cell-line
#7
S Sibel Erdem, Vildan Akgul Obeidin, Turkan Yigitbasi, S Serranur Tumer, Pakize Yigit
Ovarian Cancer is one of the deadliest gynecological cancer showing high resistance to chemotherapy. Non-overlapping and synergistic combination therapies are the best option to overcome this multi-pathological silent disease. Cationic peptides (CPs) with high targeting feature and ability to pass through cell membrane induce apoptosis via disruption of cancer cell membrane. Photodynamic Therapy (PDT) is a noninvasive clinically approved treatment modality combining light activated photosensitizer, light and oxygen...
May 1, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29744670/real-time-navigation-system-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-using-projection-mapping-with-indocyanine-green-fluorescence
#8
Masahiro Takada, Megumi Takeuchi, Eiji Suzuki, Fumiaki Sato, Yoshiaki Matsumoto, Masae Torii, Nobuko Kawaguchi-Sakita, Hiroto Nishino, Satoru Seo, Etsuro Hatano, Masakazu Toi
BACKGROUND: Inability to visualize indocyanine green fluorescence images in the surgical field limits the application of current near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node (SLN) biopsy in breast cancer patients. The aim of this study was to evaluate the usefulness of the Medical Imaging Projection System (MIPS), which uses active projection mapping, for SLN biopsy. METHODS: A total of 56 patients (59 procedures) underwent SLN biopsy using the MIPS between March 2016 and November 2017...
May 9, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29740437/targeting-and-therapy-of-glioblastoma-in-a-mouse-model-using-exosomes-derived-from-natural-killer-cells
#9
Liya Zhu, Ji Min Oh, Prakash Gangadaran, Senthilkumar Kalimuthu, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Objective: Glioblastoma is a highly aggressive primary brain tumor that is resistant to radiotherapy and chemotherapy. Natural killer (NK) cells have been used to treat incurable cancers. Recent studies have investigated the effectiveness of NK-cell-derived exosomes (NK-Exo) for treating incurable cancers such as melanoma, leukemia, and neuroblastoma; however, NK-Exo have not been used to treat glioblastoma. In the present study, we investigated the antitumor effects of NK-Exo against aggressive glioblastoma both in vitro and in vivo and determined the tumor-targeting ability of NK-Exo by performing fluorescence imaging...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29731331/-advances-in-the-management-of-cervical-lymphadenopathies-of-unknown-primary-with-intensity-modulated-radiotherapy-doses-and-target-volumes
#10
I Troussier, G Klausner, E Blais, P Giraud, L Lahmi, C Pflumio, J-C Faivre, L Geoffrois, E Babin, S Morinière, P Maingon, J Thariat
The definition of nodal and/or mucosal target volumes for radiation therapy for lymphadenopathies of unknown primary is controversial. Target volumes may include all nodal areas bilaterraly and be pan-mucosal or unilateral, selective, including the sole oropharyngeal mucosa. This review presents current recommendations in light of changes in the TNM classification, Human papillomavirus status and therapeutic advances. We conducted a systematic review of the literature with the following keywords: lymphadenopathy; head and neck; unknown primary and radiation therapy...
May 3, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29723075/orlistat-as-a-fasn-inhibitor-and-multitargeted-agent-for-cancer-therapy
#11
Alejandro Schcolnik-Cabrera, Alma Chávez-Blanco, Guadalupe Domínguez-Gómez, Lucia Taja-Chayeb, Rocio Cardenas-Barcenas, Catalina Trejo-Becerril, Enrique Perez-Cardenas, Aurora Gonzalez-Fierro, Alfonso Dueñas-González
Cancer cells have increased glycolysis and glutaminolysis. Their third feature is increased de novo lipogenesis. As such, fatty acid (FA) synthesis enzymes are over-expressed in cancer and their depletion causes antitumor effects. As fatty acid synthase (FASN) plays a pivotal role in this process, it is an attractive target for cancer therapy. Areas covered: This is a review of the lipogenic phenotype of cancer and how this phenomenon can be exploited for cancer therapy using inhibitors of FASN, with particular emphasis on orlistat as a repurposing drug...
May 3, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29721093/graphene-oxide-sensitizes-cancer-cells-to-chemotherapeutics-by-inducing-early-autophagy-events-promoting-nuclear-trafficking-and-necrosis
#12
Kuan-Chen Lin, Mei-Wei Lin, Mu-Nung Hsu, Guan Yu-Chen, Yu-Chan Chao, Hsing-Yu Tuan, Chi-Shiun Chiang, Yu-Chen Hu
Rationale: Cisplatin (CDDP) is a broad-spectrum anticancer drug but chemoresistance to CDDP impedes its wide use for cancer therapy. Autophagy is an event occurring in the cytoplasm and cytoplasmic LC3 puncta formation is a hallmark of autophagy. Graphene oxide (GO) is a nanomaterial that provokes autophagy in CT26 colon cancer cells and confers antitumor effects. Here we aimed to evaluate whether combined use of GO with CDDP (GO/CDDP) overcomes chemoresistance in different cancer cells and uncover the underlying mechanism...
2018: Theranostics
https://www.readbyqxmd.com/read/29717133/kinesin-light-chain-4-depletion-induces-apoptosis-of-radioresistant-cancer-cells-by-mitochondrial-dysfunction-via-calcium-ion-influx
#13
Jeong-Hwa Baek, Janet Lee, Hong Shik Yun, Chang-Woo Lee, Jie-Young Song, Hong-Duck Um, Jong Kuk Park, In-Chul Park, Jae-Sung Kim, Eun Ho Kim, Sang-Gu Hwang
Kinesins act as molecular microtubule-dependent motor proteins and have various important cellular functions related to cell division, intracellular transport, and membrane trafficking. However, the function of kinesin light chain 4 (KLC4) in cancer, especially radioresistance, has not been previously described. Thus, we investigated KLC4 function in lung cancer cells and radioresistant R-H460 cells by analyzing alterations in radiosensitivity after gene knockdown with siRNA and by evaluating cellular phenotypes and xenograft tumor growth...
May 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29714194/synchrotron-x-ray-microbeam-dosimetry-with-a-20-micrometre-resolution-scintillator-fibre-optic-dosimeter
#14
James Archer, Enbang Li, Marco Petasecca, Andrew Stevenson, Jayde Livingstone, Andrew Dipuglia, Jeremy Davis, Anatoly Rosenfeld, Michael Lerch
Cancer is one of the leading causes of death worldwide. External beam radiation therapy is one of the most important modalities for the treatment of cancers. Synchrotron microbeam radiation therapy (MRT) is a novel pre-clinical therapy that uses highly spatially fractionated X-ray beams to target tumours, allowing doses much higher than conventional radiotherapies to be delivered. A dosimeter with a high spatial resolution is required to provide the appropriate quality assurance for MRT. This work presents a plastic scintillator fibre optic dosimeter with a one-dimensional spatial resolution of 20 µm, an improvement on the dosimeter with a resolution of 50 µm that was demonstrated in previous work...
May 1, 2018: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/29703163/development-of-a-computational-promoter-with-highly-efficient-expression-in-tumors
#15
Shu-Yi Ho, Bo-Hau Chang, Chen-Han Chung, Yu-Ling Lin, Cheng-Hsun Chuang, Pei-Jung Hsieh, Wei-Chih Huang, Nu-Man Tsai, Sheng-Chieh Huang, Yen-Ku Liu, Yu-Chih Lo, Kuang-Wen Liao
BACKGROUND: Gene therapy is a potent method to increase the therapeutic efficacy against cancer. However, a gene that is specifically expressed in the tumor area has not been identified. In addition, nonspecific expression of therapeutic genes in normal tissues may cause side effects that can harm the patients' health. Certain promoters have been reported to drive therapeutic gene expression specifically in cancer cells; however, low expression levels of the target gene are a problem for providing good therapeutic efficacy...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29702258/photodynamic-therapy-does-not-induce-cyclobutane-pyrimidine-dimers-in-the-presence-of-melanin
#16
Shaila Mudambi, Paula Pera, Deschana Washington, Eva Remenyik, Eszter Fidrus, Gal Shafirstein, David Bellnier, Gyorgy Paragh
Photodynamic therapy (PDT) is an office-based treatment for precancerous and early cancerous skin changes. PDT induces cell death through the production of reactive oxygen species (ROS). Cyclobutane pyrimidine dimers (CPDs) are the most important DNA changes responsible for ultraviolet (UV) carcinogenesis. Recently ROS induced by UVA were shown to generate CPDs via activating melanin. This raised the possibility that PDT induced ROS may also induce CPDs and mutagenesis in melanin containing cells. Previously the effect of PDT on CPDs in melanin containing cells has not been assessed...
April 24, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29697100/the-comparative-effect-of-wrapping-solid-gold-nanoparticles-and-hollow-gold-nanoparticles-with-doxorubicin-loaded-thermosensitive-liposomes-for-cancer-thermo-chemotherapy
#17
Yanan Li, Dongsheng He, Jiasheng Tu, Ru Wang, Chang Zu, You Chen, Wenqian Yang, Di Shi, Thomas J Webster, Yan Shen
Since conventional chemotherapy is a systemic treatment that affects the body globally and will not concentrate inside the tumor, it causes adverse side effects to patients. In this study, doxorubicin (DOX) together with solid gold nanoparticles (GNPs) or hollow gold nanoparticles (HGNPs), respectively, is loaded inside thermosensitive liposomes (GNPs&DOX-TLs and HGNPs&DOX-TLs), where the GNPs and HGNPs act as a "nanoswitch" for killing tumor cells directly by hyperthermia and triggering DOX release from TLs in the tumor quickly by near infrared laser (NIR) illumination...
April 26, 2018: Nanoscale
https://www.readbyqxmd.com/read/29685157/estrogen-induced-mir-196a-elevation-promotes-tumor-growth-and-metastasis-via-targeting-spred1-in-breast-cancer
#18
Cheng-Fei Jiang, Zhu-Mei Shi, Dong-Mei Li, Ying-Chen Qian, Yi Ren, Xiao-Ming Bai, Yun-Xia Xie, Lin Wang, Xin Ge, Wei-Tao Liu, Lin-Lin Zhen, Ling-Zhi Liu, Bing-Hua Jiang
BACKGROUND: Estrogen plays a critical role in breast cancer (BC) progression through estrogen receptor (ER)-mediated gene regulation. Emerging studies suggest that the malignant progress of BC cells is influenced by the cross talk between microRNAs (miRNAs) and ER-α signaling. However, the mechanism and functional linkage between estrogen and miRNAs remain unclear. METHODS: The expression levels of miR-196a and SPRED1 in BC were tested by qRT-PCR in 46 paired BC and adjacent tissues and by the GEO datasets...
April 23, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29683291/daylight-pdt-for-field-cancerization-lessons-from-molecular-biology
#19
Max Rybarski, Lutz Schmitz, Ben Novak, Thomas Dirschka
Actinic keratoses (AKs) represent in-situ squamous cell carcinomas that potentially invade subepidermal structures and may metastasize. Until now, it is unpredictable to determine which AK lesions show this aggressive behaviour. As AKs usually occur in large sun exposed areas, field-directed treatments have become the standard treatment regimen. Among these, conventional photodynamic therapy (cPDT) with 5- aminolaevulinic acid (ALA) or methyl-aminolevulinate (MAL) using red light is particularly effective in the treatment of AKs, but acceptance of the therapy is impaired by severe pain during treatment...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29673644/3d-mesoscopic-fluorescence-tomography-for-imaging-micro-distribution-of-antibody-photon-absorber-conjugates-during-near-infrared-photoimmunotherapy-in-vivo
#20
Qinggong Tang, Tadanobu Nagaya, Yi Liu, Hannah Horng, Jonathan Lin, Kazuhide Sato, Hisataka Kobayashi, Yu Chen
As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR light, PIT can induce highly-selective cancer cell death while leaving most of tumor blood vessels unharmed, leading to an effect termed super-enhanced permeability and retention (SUPR), which can significantly improve the effectiveness of anti-cancer drug...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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