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https://www.readbyqxmd.com/read/28803033/the-risk-of-tumour-recurrence-in-patients-undergoing-renal-transplantation-for-end-stage-renal-disease-after-previous-treatment-for-a-urological-cancer-a-systematic-review
#1
REVIEW
Romain Boissier, Vital Hevia, Harman Max Bruins, Klemens Budde, Arnaldo Figueiredo, Enrique Lledó-García, Jonathon Olsburgh, Heinz Regele, Claire Fraser Taylor, Rhana Hassan Zakri, Cathy Yuhong Yuan, Alberto Breda
CONTEXT: Renal transplantation is the gold standard renal replacement therapy in end-stage renal disease owing to its superior survival and quality of life compared with dialysis. When the potential recipient has a history of cancer, the waiting period before radiotherapy is usually based on the Cincinnati Registry. OBJECTIVE: To systematically review all available evidence on the risk of cancer recurrence in end-stage renal disease patients with a history of urological cancer...
August 9, 2017: European Urology
https://www.readbyqxmd.com/read/28795851/selective-induction-of-apoptosis-in-mcf7-cancer-cell-by-targeted-liposomes-functionalized-with-mannose-6-phosphate
#2
Cristina Minnelli, Laura Cianfruglia, Emiliano Laudadio, Roberta Galeazzi, Michela Pisani, Emanuela Crucianelli, Davide Bizzaro, Tatiana Armeni, Giovanna Mobbili
Liposomes are versatile platforms to carry anticancer drugs in targeted drug delivery; they can be surface modified by different strategies and, when coupled with targeting ligands, are able to increase cellular internalization and organelle-specific drug delivery. An interesting strategy of antitumoral therapy could involve the use of lysosomotropic ligand-targeted liposomes loaded with molecules, which can induce lysosomal membrane permeabilization (LMP), leakage of cathepsins into the cytoplasm and subsequent apoptosis...
August 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28794264/liquid-phase-electron-microscopy-of-molecular-drug-response-in-breast-cancer-cells-reveals-irresponsive-cell-subpopulations-related-to-lack-of-her2-homodimers
#3
Diana B Peckys, Ulrike Korf, Stefan Wiemann, Niels de Jonge
The development of drug resistance in cancer poses a major clinical problem. An example is human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer often treated with anti-HER2 antibody therapies, such as trastuzumab. Since drug resistance is rooted mainly in tumor cell heterogeneity, we examined the drug effect in different subpopulations of SKBR3 breast cancer cells, and compared the results with a drug resistant cell line, HCC1954. Correlative light microscopy and liquid-phase scanning transmission electron microscopy (STEM) were used to quantitatively analyze HER2 responses upon drug binding, whereby many tens of whole cells were imaged...
August 9, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28790340/verteporfin-inhibits-growth-of-human-glioma-in-vitro-without-light-activation
#4
Ahmad Al-Moujahed, Katarzyna Brodowska, Tomasz P Stryjewski, Nikolaos E Efstathiou, Ioannis Vasilikos, Joanna Cichy, Joan W Miller, Evangelos Gragoudas, Demetrios G Vavvas
Verteporfin (VP), a light-activated drug used in photodynamic therapy for the treatment of choroidal neovascular membranes, has also been shown to be an effective inhibitor of malignant cells. Recently, studies have demonstrated that, even without photo-activation, VP may still inhibit certain tumor cell lines, including ovarian cancer, hepatocarcinoma and retinoblastoma, through the inhibition of the YAP-TEAD complex. In this study, we examined the effects of VP without light activation on human glioma cell lines (LN229 and SNB19)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782050/theranostic-gold-nanoantennas-for-simultaneous-multiplexed-raman-imaging-of-immunomarkers-and-photothermal-therapy
#5
Joseph A Webb, Yu-Chuan Ou, Shannon Faley, Eden P Paul, Joseph P Hittinger, Camden C Cutright, Eugene C Lin, Leon M Bellan, Rizia Bardhan
In this study, we demonstrate the theranostic capability of actively targeted, site-specific multibranched gold nanoantennas (MGNs) in triple-negative breast cancer (TNBC) cells in vitro. By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. A 1:1 mixture of MGNs functionalized with anti-PDL1 antibodies and Raman tag 5,5-dithio-bis-(2-nitrobenzoic acid) (DTNB) and MGNs functionalized with anti-EGFR antibodies and Raman tag para-mercaptobenzoic acid (pMBA) were incubated with the cells...
July 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28766338/near-infrared-light-responsive-magnetic-dna-microgels-for-photon-and-magneto-manipulated-cancer-therapy
#6
Yitong Wang, Ling Wang, Miaomiao Yan, Shuli Dong, Jingcheng Hao
Functional DNA molecules have been introduced into polymer-based nanocarrier systems to incorporate chemotherapy drugs for the cancer therapy. Here is the first report the dual-responsive microgels composed of core of Au-nanorods and shell of magnetic ionic liquid and DNA moieties in the crosslinking network simultaneously as effective drug delivery vectors. TEM images indicated a magnetic polymer shell has an analogous "doughnut" shape which is loosely surrounded around the AuNRs core. When irradiated with a near-infrared-light (NIR) laser, Au-nanorods are the motors which convert the light to the heat, leading to the release of the encapsulated payloads with high controllability...
August 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28766210/positive-ultrasound-guided-lymph-node-needle-biopsy-in-breast-cancer-may-not-mandate-axillary-lymph-node-dissection
#7
Christine K Harris, Hanh Tam Tran, Katherine Lee, Charles Mylander, Daina Pack, Martin Rosman, Lorraine Tafra, Christopher B Umbricht, Reema Andrade, Wen Liang, Rubie Sue Jackson
BACKGROUND: The ACOSOG Z0011 (Z11) trial demonstrated that in patients with nonpalpable axillary lymph nodes (LN) and one to two positive sentinel LN (SLN), axillary LN dissection (ALND) is unnecessary.JAMA 305:569-575, [2011], Ann Surg 264:413-42, [2016] The Z11 trial did not require preoperative axillary ultrasound (axUS). In many centers, preoperative axUS is part of the standard workup of a newly diagnosed breast cancer patient, but in light of the Z11 results, its role is now questioned...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28763105/physiological-doses-of-red-light-induce-il-4-release-in-co-cultures-between-human-keratinocytes-and-immune-cells
#8
Cheryl Leong, Paul L Bigliardi, Gopu Sriram, Bijin Veonice Au, John Connolly, Mei Bigliardi-Qi
Phototherapy is routinely used for the treatment of various skin conditions and targeted therapy of superficial cancers. However, the molecular mechanisms behind their biological effects and the need for efficacy enhancing photosensitizers are not well addressed. Particularly, not much is known about the inherent effect of light from the visible spectrum on cytokine release and its downstream effects in keratinocytes and immune cells located in skin and therefore exposed to light. To address this, we delivered calibrated doses of well-defined light qualities (380 to 660 nm) to co-cultures of human keratinocytes and macrophage/dendritic cells in the absence or presence of the commonly used photosensitizer 8-methoxypsoralen (8-MOP)...
August 1, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28752174/transferrin-coated-magnetic-upconversion-nanoparticles-for-efficient-photodynamic-therapy-with-near-infrared-irradiation-and-luminescence-bioimaging
#9
Dan Wang, Lin Zhu, Yuan Pu, Jie-Xin Wang, Jian-Feng Chen, Liming Dai
In the present study, we devised a green-synthesis route to NaYF4:Gd(3+),Yb(3+),Er(3+) upconversion nanoparticles (UCNPs) by using eco-friendly paraffin liquid, instead of 1-octadecene, as a high boiling non-coordinating solvent. A multifunctional nanoplatform was then developed by coating UCNPs with biocompatible transferrin (TRF) for magnetically-assisted and near-infrared light induced photodynamic therapy and bioimaging. Protoporphyrin IX (PpIX), a clinically approved photodynamic therapy agent, was loaded into the shell layer of the TRF-coated UCNPs (UCNP@TRF nanoparticles), which can be efficiently taken up by cancer cells for photodynamic therapy...
July 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28740543/self-assembly-of-semiconducting-plasmonic-gold-nanoparticles-with-enhanced-optical-property-for-photoacoustic-imaging-and-photothermal-therapy
#10
Zhen Yang, Jibin Song, Yunlu Dai, Jingyi Chen, Feng Wang, Lisen Lin, Yijing Liu, Fuwu Zhang, Guocan Yu, Zijian Zhou, Wenpei Fan, Wei Huang, Quli Fan, Xiaoyuan Chen
Although various noble metal and semiconducting molecules have been developed as photoacoustic (PA) agents, the use of semiconducting polymer-metal nanoparticle hybrid materials to enhance PA signal has not been explored. A novel semiconducting-plasmonic nanovesicle was fabricated by self-assembly of semiconducting poly(perylene diimide) (PPDI) and poly(ethylene glycol (PEG) tethered gold nanoparticles (Au@PPDI/PEG). A highly localized and strongly enhanced electromagnetic (EM) field is distributed between adjacent gold nanoparticles in the vesicular shell, where the absorbing collapsed PPDI is present...
2017: Theranostics
https://www.readbyqxmd.com/read/28737462/co-delivery-of-hydrophilic-and-hydrophobic-drugs-by-micelles-a-new-approach-using-drug-conjugated-peg-pcl-nanoparticles
#11
H Danafar, K Rostamizadeh, S Davaran, M Hamidi
Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. A conjugate of the antitumor drug, doxorubicin, with diblock methoxy poly (ethylene glycol)-poly caprolactone (mPEG-PCL) copolymer was synthesized by the reaction of mPEG-PCL copolymer with doxorubicin in the presence of p-nitrophenylchloroformate. The conjugated copolymer was characterized in vitro by (1)H NMR, FTIR, DSC and GPC techniques. Then, the doxorubicin conjugated mPEG-PCL(DOX-mPEG-PCL) was self-assembled into micelles in the presence of curcumin in aqueous solution...
July 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28723476/charting-recent-progress-and-challenges-in-metastatic-castration-resistant-prostate-cancer-is-there-an-optimal-treatment-sequence
#12
REVIEW
Stéphane Oudard, Pablo Maroto, Gaston Demonty, Winald R Gerritsen
CONTEXT: Recent developments in the treatment of metastatic castration-resistant prostate cancer (mCRPC) have led to uncertainty about the optimal sequence of agents. OBJECTIVE: To review and assess treatment options and sequence in patients with mCRPC. EVIDENCE ACQUISITION: To identify data on the optimal use of approved treatments, we searched PubMed for studies on the use of recently approved agents for men with mCRPC published before March 2015...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28713968/inhibition-of-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-by-lncrna-aslnc02525-silencing-and-the-mechanism
#13
Zi Chen, Dongwen Xu, Tao Zhang
One of the most differentially expressed long non-coding RNAs (lncRNAs) that we identified by high throughput screening from liver cancer and para-carcinoma tissues, ASLNC02525, was highly expressed in the tissues and cell lines of liver cancer but not in adjacent tissues or normal hepatic cells. Knockdown of ASLNC02525 in hepatocellular carcinoma cells inhibited the proliferation and invasion. In the process, expression level of transcription factor twist1 (twist‑related protein 1) was reduced, but no change at transcription level was observed...
July 7, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28713002/photo-stimulation-of-persistent-luminescence-nanoparticles-enhances-cancer-cells-death
#14
Gonzalo Ramírez-García, Minerva Martínez-Alfaro, Fanny d'Orlyé, Fethi Bedioui, Nathalie Mignet, Anne Varenne, Silvia Gutiérrez-Granados, Cyrille Richard
Persistent luminescence nanoparticles made of ZnGa1.995Cr0.005O4 (ZGO-NPs) are innovative nanomaterials that emit photons during long periods of time after the end of the excitation, allowing their use as diagnosis probes for in vivo optical imaging. During the excitation process, a part of the energy is stored in traps to further emit photons over long time. However, we observed in this study that some of the energy reduces molecular oxygen to produce reactive oxygen species (ROS). Following this observation, theoxidative stress induction and cytotoxic effects of these NPs were investigated on human breast cancer cells...
July 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28708430/natural-extracellular-nanovesicles-and-photodynamic-molecules-is-there-a-future-for-drug-delivery
#15
Katsuyuki Kusuzaki, Takao Matsubara, Hiroaki Murata, Mariantonia Logozzi, Elisabetta Iessi, Rossella Di Raimo, Fabrizio Carta, Claudiu T Supuran, Stefano Fais
Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotoxic activity against tumour cells. However, to date their clinical use is limited by the side effects elicited by systemic administration. Extracellular vesicles are endogenous nanosized-carriers that have been recently introduced as a natural delivery system for therapeutic molecules...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28700237/rgd-modified-albumin-nanoconjugates-for-targeted-delivery-of-a-porphyrin-photosensitizer
#16
Fang Li, Yan Zhao, Chengqiong Mao, Yi Kong, Xin Ming
Advances in photodynamic therapy of cancer have been restrained by lack of cancer specificity and side effects to normal tissues. Molecularly targeted photodynamic therapy can achieve higher cancer specificity by combination of active cancer targeting and localized laser activation. We aimed to use albumin as a carrier to prepare targeted nanoconjugates that are selective to cancer cells and smaller than conventional nanoparticles for superior tumor penetration. IRDye 700DX (IR700), a porphyrin photosensitizer, was covalently conjugated to human serum albumin that was also linked with tumor-targeting RGD peptides...
August 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28691356/tumor-microenvironment-and-noncoding-rnas-as-co-drivers-of-epithelial-mesenchymal-transition-and-cancer-metastasis
#17
REVIEW
Kinan Drak Alsibai, Didier Meseure
Reciprocal interactions between cancer cells and tumor microenvironment (TME) are crucial events in tumor progression and metastasis. Pervasive stromal reprogramming of TME modifies numerous cellular functions including, extracellular matrix (ECM) stiffness, inflammation and immunity. These environmental factors allow selection of more aggressive cells that develop adaptive strategies associating plasticity and epithelial-mesenchymal transition (EMT), stem-like phenotype, invasion, immunosuppression, and resistance to therapies...
July 10, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28688985/mussel-inspired-plga-polydopamine-core-shell-nanoparticle-for-light-induced-cancer-thermochemotherapy
#18
Huacheng He, Eleni Markoutsa, Yihong Zhan, Jiajia Zhang, Peisheng Xu
Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body due to the uncertainty of their fate. Hereby, we developed a mussel-inspired PLGA/polydopamine core-shell nanoparticle for cancer photothermal and chemotherapy. With the help of an anti-EGFR antibody, the nanoparticle could effectively enter head and neck cancer cells and convert near-infrared light to heat to trigger drug release from PLGA core for chemotherapy as well as ablate tumors by the elevated temperature...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28684780/retinoic-acid-affects-lung-adenocarcinoma-growth-by-inducing-differentiation-via-gata6-activation-and-egfr-and-wnt-inhibition
#19
Giovanni Zito, Flores Naselli, Laura Saieva, Stefania Raimondo, Giovanna Calabrese, Claudio Guzzardo, Stefano Forte, Christian Rolfo, Rosalba Parenti, Riccardo Alessandro
A fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Here we show that Retinoic Acid (RA) arrests in vitro and in vivo the growth of Tyrosine Kinase Inhibitors (TKI) resistant Non Small Cell Lung Cancer (NSCLC). In particular, we found that RA induces G0/G1 cell cycle arrest in TKI resistant NSCLC cells and activates terminal differentiation programs by modulating the expression of GATA6, a key transcription factor involved in the physiological differentiation of the distal lung...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677575/from-class-waivers-to-precision-medicine-in-paediatric-oncology
#20
REVIEW
Andrew D J Pearson, Stefan M Pfister, Andre Baruchel, Jean-Pierre Bourquin, Michela Casanova, Louis Chesler, François Doz, Angelika Eggert, Birgit Geoerger, David T W Jones, Pamela R Kearns, Jan J Molenaar, Bruce Morland, Gudrun Schleiermacher, Johannes H Schulte, Josef Vormoor, Lynley V Marshall, C Michel Zwaan, Gilles Vassal
New drugs are crucially needed for children with cancer. The European Paediatric Regulation facilitates paediatric class waivers for drugs developed for diseases only occurring in adults. In this Review, we retrospectively searched oncology drugs that were class waivered between June, 2012, and June, 2015. 147 oncology class waivers were confirmed for 89 drugs. Mechanisms of action were then assessed as potential paediatric therapeutic targets by both a literature search and an expert review. 48 (54%) of the 89 class-waivered drugs had a mechanisms of action warranting paediatric development...
July 2017: Lancet Oncology
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