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Urinary sodium potassium ratio AND hypertension

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https://www.readbyqxmd.com/read/28123179/diurnal-variation-of-urinary-sodium-to-potassium-ratio-in-free-living-japanese-individuals
#1
Toshiyuki Iwahori, Hirotsugu Ueshima, Sayuki Torii, Yoshino Saito, Keiko Kondo, Sachiko Tanaka-Mizuno, Hisatomi Arima, Katsuyuki Miura
High sodium-to-potassium ratios are associated with elevated blood pressure levels and an increased risk of cardiovascular diseases. We aimed to determine whether urinary sodium-to-potassium ratios fluctuate diurnally during the day to understand measured values of casual urinary sodium-to-potassium ratios. A total of 13,277 casual urine specimens were collected under free-living conditions from 122 Japanese normotensive and hypertensive individuals. Participants collected all casual urine samples in aliquot tubes, reported urine volumes and the time at each voiding for 10-22 days...
January 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27935977/the-effects-of-a-community-based-sodium-reduction-program-in-rural-china-a-cluster-randomized-trial
#2
Nicole Li, Lijing L Yan, Wenyi Niu, Chen Yao, Xiangxian Feng, Jianxin Zhang, Jingpu Shi, Yuhong Zhang, Ruijuan Zhang, Zhixin Hao, Hongling Chu, Jing Zhang, Xian Li, Jianhong Pan, Zhifang Li, Jixin Sun, Bo Zhou, Yi Zhao, Yan Yu, Michael Engelgau, Darwin Labarthe, Jixiang Ma, Stephen MacMahon, Paul Elliott, Yangfeng Wu, Bruce Neal
BACKGROUND: Average sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed. OBJECTIVE: We sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China. DESIGN: This study was a cluster-randomized trial done over 18 months in 120 townships (one village from each township) from five provinces...
2016: PloS One
https://www.readbyqxmd.com/read/27754020/chl-02-3-evidence-and-initiatives-in-the-dietary-salt-reduction-in-china
#3
Chao Chu, Yumeng Cao, Jianjun Mu
BACKGROUND: Salt reduction are crucial in the management of hypertension. Over the past few decades, Series of national activities and studies focusing on salt reduction and salt intake education were promoted by the Chinese government. However, the current status of dietary sodium and potassium intake of Chinese population is unclear. OBJECTIVE: The aim of this study is to analyze the status of dietary salt and potassium intake in the Chinese population through summarizing the previous studies from 1998 to 2011 and then propose appropriate initiatives...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753931/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#4
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753910/os-03-02-stronger-associations-of-urinary-sodium-to-potassium-ratio-with-blood-pressure-results-from-a-prospective-cohort-study-in-china
#5
Lu Yin, Xinhua Zhang, Xingyu Wang, Yang Wang, Jian Bo, Wei Li
OBJECTIVE: To evaluate the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with ratio for urinary sodium versus potassium in a large prospective urban and rural epidemiological study in China (PURE-China). DESIGN AND METHOD: As the important part of global multi-center PURE study, a prospective cohort study was conducted to recruit 46,285 participants in urban and rural area of 12 provinces in China between 2005 and 2009. A single fasting morning urine specimen was collected to test sodium and potassium excretion, and the Kawasaki formula was used to estimate 24-hour urinary sodium and potassium excretion...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27712964/relationship-between-sodium-and-potassium-intake-and-blood-pressure-in-a-sample-of-overweight-adults
#6
Rhoda N Ndanuko, Linda C Tapsell, Karen E Charlton, Elizabeth P Neale, Katrina M O'Donnell, Marijka J Batterham
OBJECTIVE: The aim of this study was to examine the relationship between sodium and potassium intakes and blood pressure (BP) in a clinical sample. METHODS: Secondary analysis of baseline data from 328 participants (mean age: 43.6 ± 8 y, mean body mass index [BMI]: 32.4 ± 4.2 kg/m(2), mean systolic BP [SBP]/diastolic BP [DBP]: 124.9 ± 14.5/73.3 ± 9.9 mm Hg) of the 12-mo HealthTrack randomized controlled weight loss trial was conducted. Resting BP and 24-h urine sodium and potassium were measured...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27712772/sodium-intake-and-all-cause-mortality-over-20-years-in-the-trials-of-hypertension%C3%A2-prevention
#7
Nancy R Cook, Lawrence J Appel, Paul K Whelton
BACKGROUND: The relationship between lower sodium intake and total mortality remains controversial. OBJECTIVES: This study examined the relationship between well-characterized measures of sodium intake estimated from urinary sodium excretion and long-term mortality. METHODS: Two trials, phase I (1987 to 1990), over 18 months, and phase II (1990 to 1995), over 36 months, were undertaken in TOHP (Trials of Hypertension Prevention), which implemented sodium reduction interventions...
October 11, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27702722/population-based-association-between-urinary-excretion-of-sodium-potassium-and-its-ratio-with-albuminuria-in-chinese
#8
Liuxia Yan, Xiaolei Guo, Huicheng Wang, Jiyu Zhang, Junli Tang, Zilong Lu, Xiaoning Cai, Longjian Liu, Edward J Gracely, Jixiang Ma
BACKGROUND AND OBJECTIVES: Albuminuria is a risk factor for cardiovascular and renal disease. However, little is known about the association of 24 h urinary sodium and potassium excretion with albuminuria in China. The aim of this study was to examine this association by analyzing the data from 1,975 Chinese adults living in north China. METHODS AND STUDY DESIGN: Excretion of urinary sodium, potassium and albumin was assessed in a single 24-h urine sample for each participant...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27643324/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#9
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643258/os-03-02-stronger-associations-of-urinary-sodium-to-potassium-ratio-with-blood-pressure-results-from-a-prospective-cohort-study-in-china
#10
Lu Yin, Xinhua Zhang, Xingyu Wang, Yang Wang, Jian Bo, Wei Li
OBJECTIVE: To evaluate the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with ratio for urinary sodium versus potassium in a large prospective urban and rural epidemiological study in China (PURE-China). DESIGN AND METHOD: As the important part of global multi-center PURE study, a prospective cohort study was conducted to recruit 46,285 participants in urban and rural area of 12 provinces in China between 2005 and 2009. A single fasting morning urine specimen was collected to test sodium and potassium excretion, and the Kawasaki formula was used to estimate 24-hour urinary sodium and potassium excretion...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642938/chl-02-3-evidence-and-initiatives-in-the-dietary-salt-reduction-in-china
#11
Chao Chu, Yumeng Cao, Jianjun Mu
BACKGROUND: Salt reduction are crucial in the management of hypertension. Over the past few decades, Series of national activities and studies focusing on salt reduction and salt intake education were promoted by the Chinese government. However, the current status of dietary sodium and potassium intake of Chinese population is unclear. OBJECTIVE: The aim of this study is to analyze the status of dietary salt and potassium intake in the Chinese population through summarizing the previous studies from 1998 to 2011 and then propose appropriate initiatives...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508584/-op-8e-03-relation-between-24-hours-urinary-sodium-and-potassium-excretion-and-blood-pressure-in-rural-and-urban-pygmies-and-bantus-of-southern-cameroon
#12
D Lemogoum, Y Hako, C Bika Lele, C Okalla, J Dissongo, J M'buyamba-Kabangu, J Degaute, M Leeman, P van de Borne
OBJECTIVE: To assess the association between 24 hours urinary sodium and potassium excretion with blood pressure (BP) in rural and urban pygmies and Bantus of southern Cameroon. DESIGN AND METHOD: In this cross-sectional survey, we compared 100 traditional pygmies (TP) living in equatorial forest (Lolodorf) and their 100 neighbors traditional Bantus (TB) living in Bidjouka village, to 100 contemporary pygmies (CP) and 100 contemporary Bantus (CB) both living in urban environment in Kribi city...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27381844/in-primary-aldosteronism-mineralocorticoids-influence-exosomal-sodium-chloride-cotransporter-abundance
#13
Martin J Wolley, Aihua Wu, Shengxin Xu, Richard D Gordon, Robert A Fenton, Michael Stowasser
Distal tubular sodium retention is a potent driver of hypertension, and the thiazide-sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldosterone is a potent regulator, possibly via effects on plasma potassium. We studied the effects of the mineralocorticoid fludrocortisone on the abundance of NCC and its phosphorylated form (pNCC) as well as WNK lysine deficient protein kinase 4 (WNK4) and STE20/SPS1-related, proline alanine-rich kinase (SPAK) in human urinary exosomes...
January 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27072344/sodium-and-potassium-urinary-excretion-and-dietary-intake-a-cross-sectional-analysis-in-adolescents
#14
Carla Gonçalves, Sandra Abreu, Patrícia Padrão, Olívia Pinho, Pedro Graça, João Breda, Rute Santos, Pedro Moreira
BACKGROUND: Hypertension is the leading cause for heart disease and stroke, for mortality and morbidity worldwide, and a high sodium-to-potassium intake ratio is considered a stronger risk factor for hypertension than sodium alone. OBJECTIVE: This study aims to evaluate sodium and potassium urinary excretion, and assess the food sources of these nutrients in a sample of Portuguese adolescents. DESIGN: A cross-sectional study with a sample of 250 Portuguese adolescents...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27055519/association-of-estimated-sodium-and-potassium-intake-with-blood-pressure-in-patients-with-systemic-lupus-erythematosus
#15
A Barnado, A Oeser, Y Zhang, C R Okafor, J Titze, C M Stein, C P Chung
Sodium and potassium intake are modifiable determinants of hypertension in the general population but have not been studied in patients with systemic lupus erythematosus (SLE). We examined the relationship between urinary excretion of sodium and potassium, as an estimate of intake, and blood pressure in patients with SLE. We studied 178 SLE patients and 86 controls, matched for age, sex, and race. Urine sodium (Na(+)) and potassium (K(+)) were measured by flame photometry. Blood pressure was the average of two resting measurements...
November 2016: Lupus
https://www.readbyqxmd.com/read/26430087/examination-of-potential-modifiers-of-the-association-of-apol1-alleles-with-ckd-progression
#16
RANDOMIZED CONTROLLED TRIAL
Teresa K Chen, Michael J Choi, W H Linda Kao, Brad C Astor, Julia J Scialla, Lawrence J Appel, Liang Li, Michael S Lipkowitz, Myles Wolf, Rulan S Parekh, Cheryl A Winkler, Michelle M Estrella, Deidra C Crews
BACKGROUND AND OBJECTIVES: Common apolipoprotein L1 (APOL1) variants are associated with increased risk of progressive CKD; however, not all individuals with high-risk APOL1 variants experience CKD progression. Identification of factors contributing to heterogeneity has important scientific and clinical implications. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using multivariable Cox models, we analyzed data from 693 participants in the African American Study of Kidney Disease and Hypertension to identify factors that modify the association between APOL1 genotypes and CKD progression (doubling of serum creatinine or incident ESRD)...
December 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26378682/descriptive-epidemiology-of-spot-urine-sodium-to-potassium-ratio-clarified-close-relationship-with-blood-pressure-level-the-nagahama-study
#17
Yasuharu Tabara, Yoshimitsu Takahashi, Kyoko Kumagai, Kazuya Setoh, Takahisa Kawaguchi, Meiko Takahashi, Yuki Muraoka, Akitaka Tsujikawa, Norimoto Gotoh, Chikashi Terao, Ryo Yamada, Shinji Kosugi, Akihiro Sekine, Nagahisa Yoshimura, Takeo Nakayama, Fumihiko Matsuda
OBJECTIVES: We undertook descriptive epidemiology of spot urine sodium-to-potassium ratio (Na/K) in a population sample to clarify the close relationship between Na/K and blood pressure level independently of potential confounding factors. METHODS: Study participants consisted of 9144 apparently healthy citizens (aged 54 ± 13 years). All clinical parameters were obtained at baseline. RESULTS: Na/K was significantly higher in hypertensive individuals irrespective of antihypertensive medication status (normotension, 3...
December 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26332433/relationships-between-blood-pressure-and-24-hour-urinary-excretion-of-sodium-and-potassium-by-body-mass-index-status-in-chinese-adults
#18
Liuxia Yan, Zhenqiang Bi, Junli Tang, Linhong Wang, Quanhe Yang, Xiaolei Guo, Mary E Cogswell, Xiaofei Zhang, Yuling Hong, Michael Engelgau, Jiyu Zhang, Paul Elliott, Sonia Y Angell, Jixiang Ma
This study examined the impact of overweight/obesity on sodium, potassium, and blood pressure associations using the Shandong-Ministry of Health Action on Salt Reduction and Hypertension (SMASH) project baseline survey data. Twenty-four-hour urine samples were collected in 1948 Chinese adults aged 18 to 69 years. The observed associations of sodium, potassium, sodium-potassium ratio, and systolic blood pressure (SBP) were stronger in the overweight/obese population than among those of normal weight. Among overweight/obese respondents, each additional standard deviation (SD) higher of urinary sodium excretion (SD=85 mmol) and potassium excretion (SD=19 mmol) was associated with a 1...
December 2015: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/26311164/altitudes-of-residential-areas-affect-salt-intake-in-a-rural-area-in-japan-a-shimane-cohre-study
#19
Sonia I Ferdaus, Kunie Kohno, Tsuyoshi Hamano, Miwako Takeda, Masayuki Yamasaki, Minoru Isomura, Kuninori Shiwaku, Toru Nabika
There is increasing evidence of an association between residential environments and hypertension. As shown in our previous study, the inconvenience of the locations of residential areas may be one of the factors influencing the blood pressures of inhabitants. Salt intake is one of the likely mediators between inconvenience and hypertension. Therefore, in this study, we evaluated the association between the altitudes of residential areas and salt intake in a rural Japanese region because altitude may be one of the proxies for inconvenience...
December 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/26310187/four-to-seven-random-casual-urine-specimens-are-sufficient-to-estimate-24-h-urinary-sodium-potassium-ratio-in-individuals-with-high-blood-pressure
#20
T Iwahori, H Ueshima, S Torii, Y Saito, A Fujiyoshi, T Ohkubo, K Miura
This study was done to clarify the optimal number and type of casual urine specimens required to estimate urinary sodium/potassium (Na/K) ratio in individuals with high blood pressure. A total of 74 individuals with high blood pressure, 43 treated and 31 untreated, were recruited from the Japanese general population. Urinary sodium, potassium and Na/K ratio were measured in both casual urine samples and 7-day 24-h urine samples and then analyzed by correlation and Bland-Altman analyses. Mean Na/K ratio from random casual urine samples on four or more days strongly correlated with the Na/K ratio of 7-day 24-h urine (r=0...
May 2016: Journal of Human Hypertension
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