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Urinary sodium potassium ratio AND hypertension

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https://www.readbyqxmd.com/read/28633342/biomarker-calibrated-sodium-and-potassium-intake-and-cardiovascular-disease-risk-among-postmenopausal-women
#1
Ross L Prentice, Ying Huang, Marian L Neuhouser, JoAnn E Manson, Yasmin Mossavar-Rahmani, Fridtjof Thomas, Lesley F Tinker, Matthew Allison, Karen C Johnson, Sylvia Wassertheil-Smoller, Arjun Seth, Jacques E Rossouw, James Shikany, Laura D Carbone, Lisa W Martin, Marcia L Stefanick, Bernhard Haring, Linda Van Horn
Studies of sodium and potassium intake and cardiovascular disease incidence often rely on self-reported dietary data. Here self-reported intakes from postmenopausal women at 40 participating U.S. clinical centers are calibrated using 24-hour urinary excretion measures in Women's Health Initiative cohorts, with follow-up over 1993-2010. Hypertension incidence related positively to (calibrated) sodium intake and to the ratio of sodium-to-potassium. The sodium-to-potassium ratio was associated with cardiovascular disease incidence during a 12-year average follow-up period...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28559392/renal-dysfunction-induced-by-kidney-specific-gene-deletion-of-hsd11b2-as-a-primary-cause-of-salt-dependent-hypertension
#2
Kohei Ueda, Mitsuhiro Nishimoto, Daigoro Hirohama, Nobuhiro Ayuzawa, Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Johannes Loffing, Ming-Zhi Zhang, Takeshi Marumo, Toshiro Fujita
Genome-wide analysis of renal sodium-transporting system has identified specific variations of Mendelian hypertensive disorders, including HSD11B2 gene variants in apparent mineralocorticoid excess. However, these genetic variations in extrarenal tissue can be involved in developing hypertension, as demonstrated in former studies using global and brain-specific Hsd11b2 knockout rodents. To re-examine the importance of renal dysfunction on developing hypertension, we generated kidney-specific Hsd11b2 knockout mice...
May 30, 2017: Hypertension
https://www.readbyqxmd.com/read/28498883/prognostic-significance-of-spot-urine-na-k-for-longitudinal-changes-in-blood-pressure-and-renal-function-the-nagahama-study
#3
Yasuharu Tabara, Yoshimitsu Takahashi, Kazuya Setoh, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Fumihiko Matsuda
BACKGROUND: Urinary sodium-to-potassium ratio (Na/K) represents a simple measure of sodium load and has been reported to be associated with blood pressure (BP) levels in a cross-sectional setting even with spot measurements. The aim of the present large-scale cohort study is to determine prognostic significance of spot urine Na/K for longitudinal changes in BP levels and renal function. METHODS: The present study population consisted of 7,063 individuals from the general population...
May 12, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28494444/associations-of-usual-24-hour-sodium-and-potassium-intakes-with-blood-pressure-and-risk-of-hypertension-among-adults-in-china-s-shandong-and-jiangsu-provinces
#4
Jianwei Xu, Xiaorong Chen, Zeng Ge, Hao Liang, Liuxia Yan, Xiaolei Guo, Yongqing Zhang, Linhong Wang, Jixiang Ma
BACKGROUND/AIMS: High sodium intake and low intake of potassium can increase blood pressure (BP) and risk of developing hypertension. Few studies have examined the association between 24-h urinary sodium and potassium excretion and BP or risk of hypertension in China, and most used only a single 24-h urinary sample. METHODS: We analyzed data on 2281 participants aged 18-69 years by using two 24-h urinary sodium and potassium excretions from the supplemental baseline survey of the Shandong-Ministry of Health Action on Salt Reduction and Hypertension (SMASH) project...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28322418/associations-of-sodium-potassium-and-protein-intake-with-blood-pressure-and-hypertension-in-switzerland
#5
Nicolas Glatz, Aline Chappuis, David Conen, Paul Erne, Antoinette Péchère-Bertschi, Idris Guessous, Valentina Forni, Luca Gabutti, Franco Muggli, Augusto Gallino, Daniel Hayoz, Isabelle Binet, Paolo Suter, Fred Paccaud, Murielle Bochud, Michel Burnier
BACKGROUND: Nutritional factors play an important role in the regulation of blood pressure and in the development of hypertension. In this analysis, we explored the associations of 24-hour urinary Na+, K+ and urea excretion with blood pressure levels and the risk of hypertension in the Swiss population, taking regional linguistic differences into account. METHODS: The Swiss Survey on Salt is a population based cross-sectional study that included 1336 subjects from the three main linguistic regions (French, German and Italian) of Switzerland...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28289182/continuum-of-renin-independent-aldosteronism-in-normotension
#6
Rene Baudrand, Francisco J Guarda, Carlos Fardella, Gregory Hundemer, Jenifer Brown, Gordon Williams, Anand Vaidya
Primary aldosteronism is a severe form of autonomous aldosteronism. Milder forms of autonomous and renin-independent aldosteronism may be common, even in normotension. We characterized aldosterone secretion in 210 normotensives who had suppressed plasma renin activity (<1.0 ng/mL per hour), completed an oral sodium suppression test, received an infusion of angiotensin II, and had measurements of blood pressure and renal plasma flow. Continuous associations between urinary aldosterone excretion rate, renin, and potassium handling were investigated...
May 2017: Hypertension
https://www.readbyqxmd.com/read/28273873/interaction-between-single-nucleotide-polymorphism-and-urinary-sodium-potassium-and-sodium-potassium-ratio-on-the-risk-of-hypertension-in-korean-adults
#7
Yeong Mi Park, Chang Keun Kwock, Kyunga Kim, Jihye Kim, Yoon Jung Yang
Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Tanaka and Kawasaki formulas were applied to estimate 24 h urinary sodium and potassium excretion...
March 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28123179/diurnal-variation-of-urinary-sodium-to-potassium-ratio-in-free-living-japanese-individuals
#8
Toshiyuki Iwahori, Hirotsugu Ueshima, Sayuki Torii, Yoshino Saito, Keiko Kondo, Sachiko Tanaka-Mizuno, Hisatomi Arima, Katsuyuki Miura
High sodium-to-potassium ratios are associated with elevated blood pressure levels and an increased risk of cardiovascular diseases. We aimed to determine whether urinary sodium-to-potassium ratios fluctuate diurnally during the day to understand measured values of casual urinary sodium-to-potassium ratios. A total of 13,277 casual urine specimens were collected under free-living conditions from 122 Japanese normotensive and hypertensive individuals. Participants collected all casual urine samples in aliquot tubes, reported urine volumes and the time at each voiding for 10-22 days...
January 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27935977/the-effects-of-a-community-based-sodium-reduction-program-in-rural-china-a-cluster-randomized-trial
#9
Nicole Li, Lijing L Yan, Wenyi Niu, Chen Yao, Xiangxian Feng, Jianxin Zhang, Jingpu Shi, Yuhong Zhang, Ruijuan Zhang, Zhixin Hao, Hongling Chu, Jing Zhang, Xian Li, Jianhong Pan, Zhifang Li, Jixin Sun, Bo Zhou, Yi Zhao, Yan Yu, Michael Engelgau, Darwin Labarthe, Jixiang Ma, Stephen MacMahon, Paul Elliott, Yangfeng Wu, Bruce Neal
BACKGROUND: Average sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed. OBJECTIVE: We sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China. DESIGN: This study was a cluster-randomized trial done over 18 months in 120 townships (one village from each township) from five provinces...
2016: PloS One
https://www.readbyqxmd.com/read/27754020/chl-02-3-evidence-and-initiatives-in-the-dietary-salt-reduction-in-china
#10
Chao Chu, Yumeng Cao, Jianjun Mu
BACKGROUND: Salt reduction are crucial in the management of hypertension. Over the past few decades, Series of national activities and studies focusing on salt reduction and salt intake education were promoted by the Chinese government. However, the current status of dietary sodium and potassium intake of Chinese population is unclear. OBJECTIVE: The aim of this study is to analyze the status of dietary salt and potassium intake in the Chinese population through summarizing the previous studies from 1998 to 2011 and then propose appropriate initiatives...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753931/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#11
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753910/os-03-02-stronger-associations-of-urinary-sodium-to-potassium-ratio-with-blood-pressure-results-from-a-prospective-cohort-study-in-china
#12
Lu Yin, Xinhua Zhang, Xingyu Wang, Yang Wang, Jian Bo, Wei Li
OBJECTIVE: To evaluate the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with ratio for urinary sodium versus potassium in a large prospective urban and rural epidemiological study in China (PURE-China). DESIGN AND METHOD: As the important part of global multi-center PURE study, a prospective cohort study was conducted to recruit 46,285 participants in urban and rural area of 12 provinces in China between 2005 and 2009. A single fasting morning urine specimen was collected to test sodium and potassium excretion, and the Kawasaki formula was used to estimate 24-hour urinary sodium and potassium excretion...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27712964/relationship-between-sodium-and-potassium-intake-and-blood-pressure-in-a-sample-of-overweight-adults
#13
Rhoda N Ndanuko, Linda C Tapsell, Karen E Charlton, Elizabeth P Neale, Katrina M O'Donnell, Marijka J Batterham
OBJECTIVE: The aim of this study was to examine the relationship between sodium and potassium intakes and blood pressure (BP) in a clinical sample. METHODS: Secondary analysis of baseline data from 328 participants (mean age: 43.6 ± 8 y, mean body mass index [BMI]: 32.4 ± 4.2 kg/m(2), mean systolic BP [SBP]/diastolic BP [DBP]: 124.9 ± 14.5/73.3 ± 9.9 mm Hg) of the 12-mo HealthTrack randomized controlled weight loss trial was conducted. Resting BP and 24-h urine sodium and potassium were measured...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27712772/sodium-intake-and-all-cause-mortality-over-20-years-in-the-trials-of-hypertension%C3%A2-prevention
#14
Nancy R Cook, Lawrence J Appel, Paul K Whelton
BACKGROUND: The relationship between lower sodium intake and total mortality remains controversial. OBJECTIVES: This study examined the relationship between well-characterized measures of sodium intake estimated from urinary sodium excretion and long-term mortality. METHODS: Two trials, phase I (1987 to 1990), over 18 months, and phase II (1990 to 1995), over 36 months, were undertaken in TOHP (Trials of Hypertension Prevention), which implemented sodium reduction interventions...
October 11, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27702722/population-based-association-between-urinary-excretion-of-sodium-potassium-and-its-ratio-with-albuminuria-in-chinese
#15
Liuxia Yan, Xiaolei Guo, Huicheng Wang, Jiyu Zhang, Junli Tang, Zilong Lu, Xiaoning Cai, Longjian Liu, Edward J Gracely, Jixiang Ma
BACKGROUND AND OBJECTIVES: Albuminuria is a risk factor for cardiovascular and renal disease. However, little is known about the association of 24 h urinary sodium and potassium excretion with albuminuria in China. The aim of this study was to examine this association by analyzing the data from 1,975 Chinese adults living in north China. METHODS AND STUDY DESIGN: Excretion of urinary sodium, potassium and albumin was assessed in a single 24-h urine sample for each participant...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27643324/os-05-06-in-primary-aldosteronism-mineralocorticoids-and-potassium-influence-abundance-of-the-thiazide-sensitive-sodium-chloride-cotransporter
#16
Wolley Mj, Wu A, Xu S, Gordon Rd, Fenton Ra, Stowasser M
BACKGROUND: Distal tubular sodium retention is a potent driver of hypertension, with the thiazide sensitive sodium-chloride cotransporter (NCC) a key player. The upstream modulators of NCC are unclear, but recent evidence has revealed the kinases 'with-no-lysine kinase 4' (WNK4) and 'STE20/SPS1-related, proline alanine-rich kinase' (SPAK) to be involved. The wider role of mineralocorticoids is poorly understood, but animal models implicate aldosterone as a potent regulator, possibly via effects on plasma potassium...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643258/os-03-02-stronger-associations-of-urinary-sodium-to-potassium-ratio-with-blood-pressure-results-from-a-prospective-cohort-study-in-china
#17
Lu Yin, Xinhua Zhang, Xingyu Wang, Yang Wang, Jian Bo, Wei Li
OBJECTIVE: To evaluate the association of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with ratio for urinary sodium versus potassium in a large prospective urban and rural epidemiological study in China (PURE-China). DESIGN AND METHOD: As the important part of global multi-center PURE study, a prospective cohort study was conducted to recruit 46,285 participants in urban and rural area of 12 provinces in China between 2005 and 2009. A single fasting morning urine specimen was collected to test sodium and potassium excretion, and the Kawasaki formula was used to estimate 24-hour urinary sodium and potassium excretion...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642938/chl-02-3-evidence-and-initiatives-in-the-dietary-salt-reduction-in-china
#18
Chao Chu, Yumeng Cao, Jianjun Mu
BACKGROUND: Salt reduction are crucial in the management of hypertension. Over the past few decades, Series of national activities and studies focusing on salt reduction and salt intake education were promoted by the Chinese government. However, the current status of dietary sodium and potassium intake of Chinese population is unclear. OBJECTIVE: The aim of this study is to analyze the status of dietary salt and potassium intake in the Chinese population through summarizing the previous studies from 1998 to 2011 and then propose appropriate initiatives...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508584/-op-8e-03-relation-between-24-hours-urinary-sodium-and-potassium-excretion-and-blood-pressure-in-rural-and-urban-pygmies-and-bantus-of-southern-cameroon
#19
D Lemogoum, Y Hako, C Bika Lele, C Okalla, J Dissongo, J M'buyamba-Kabangu, J Degaute, M Leeman, P van de Borne
OBJECTIVE: To assess the association between 24 hours urinary sodium and potassium excretion with blood pressure (BP) in rural and urban pygmies and Bantus of southern Cameroon. DESIGN AND METHOD: In this cross-sectional survey, we compared 100 traditional pygmies (TP) living in equatorial forest (Lolodorf) and their 100 neighbors traditional Bantus (TB) living in Bidjouka village, to 100 contemporary pygmies (CP) and 100 contemporary Bantus (CB) both living in urban environment in Kribi city...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27381844/in-primary-aldosteronism-mineralocorticoids-influence-exosomal-sodium-chloride-cotransporter-abundance
#20
Martin J Wolley, Aihua Wu, Shengxin Xu, Richard D Gordon, Robert A Fenton, Michael Stowasser
Distal tubular sodium retention is a potent driver of hypertension, and the thiazide-sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldosterone is a potent regulator, possibly via effects on plasma potassium. We studied the effects of the mineralocorticoid fludrocortisone on the abundance of NCC and its phosphorylated form (pNCC) as well as WNK lysine deficient protein kinase 4 (WNK4) and STE20/SPS1-related, proline alanine-rich kinase (SPAK) in human urinary exosomes...
January 2017: Journal of the American Society of Nephrology: JASN
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