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https://www.readbyqxmd.com/read/27833157/association-between-the-p-thr1406asn-polymorphism-of-the-carbamoyl-phosphate-synthetase-1-gene-and-necrotizing-enterocolitis-a-prospective-multicenter-study
#1
Rob M Moonen, Giacomo Cavallaro, Maurice J Huizing, Gema E González-Luis, Fabio Mosca, Eduardo Villamor
The p.Thr1406Asn (rs1047891) polymorphism of the carbamoyl-phosphate synthetase 1 (CPS1) gene has been linked to functional consequences affecting the downstream availability of the nitric oxide precursor L-arginine. L-arginine concentrations are decreased in preterm infants with necrotizing enterocolitis (NEC). In this multicenter prospective study, we investigated the association of the p.Thr1406Asn polymorphism with NEC in 477 preterm infants (36 cases of NEC) from 4 European neonatal intensive care units (Maastricht, Las Palmas de Gran Canaria, Mantova, and Milan)...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27762063/peritoneal-dialysis-in-patients-with-failed-kidney-transplant-single-centre-experience
#2
Saurabh Chaudhri, Alice A Thomas, Nasreen Samad, Stanley L Fan
AIM: To determine if patients with failing kidney transplants who opt to have peritoneal dialysis (PD) have poor short-term PD technique survival and increased rates of peritonitis. METHODS: We performed a retrospective analysis comparing 50 consecutive patients starting PD after a failed kidney transplant to 93 incident patients starting PD (matching for age, gender, diabetes causing renal failure, ethnicity and year of starting PD). RESULTS: The mean follow-up period was 26 months...
October 20, 2016: Nephrology
https://www.readbyqxmd.com/read/27760419/relationship-between-anemia-and-serum-concentrations-of-calcium-and-phosphorus-in-advanced-non-dialysis-dependent-chronic-kidney-disease
#3
Mauro Boronat, Ángelo Santana, Elvira Bosch, Dionisio Lorenzo, Marta Riaño, César García-Cantón
BACKGROUND/AIMS: Different biochemical abnormalities of metabolic bone disease have been associated with anemia of chronic kidney disease (CKD), mainly in hemodialysis patients. However, all of these abnormalities are closely inter-related and their individual effect on the development of anemia is uncertain. This study was aimed to assess the relationship between anemia and a set of metabolic bone disease biomarkers in a cohort of adult patients with advanced non-dialysis-dependent CKD...
October 20, 2016: Nephron
https://www.readbyqxmd.com/read/27751690/the-heartworm-dirofilaria-immitis-seems-to-be-able-to-metabolize-organochlorine-pesticides-and-polychlorinated-biphenyls-a-case-control-study-in-dogs
#4
Luis A Henríquez-Hernández, Elena Carretón, María Camacho, José Alberto Montoya-Alonso, Luis D Boada, Pilar F Valerón, Yaiza Falcón-Cordón, Soraya Falcón-Cordón, Maira Almeida-González, Manuel Zumbado, Octavio P Luzardo
It has been described that the co-existence of parasite infection and chemical exposure has various effects on the accumulation of persistent organochlorine pollutants (POPs) in the host. Certain parasites are not only able to accumulate POPs but also seem to have the ability to metabolize certain compounds. We have designed a case-control study aimed to disclose the role of Dirofilaria immitis in the bioavailability of POPs in dogs trying to know whether these parasites store or metabolize the POPs. A total of 40 common POPs (18 polychlorinated biphenyls congeners (PCBs) and 22 organochlorine pesticides were quantified in dog serum...
October 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27598380/drug-drug-interactions-and-adverse-drug-reactions-in-polypharmacy-among-older-adults-an-integrative-review
#5
Maria Cristina Soares Rodrigues, Cesar de Oliveira
OBJECTIVE: to identify and summarize studies examining both drug-drug interactions (DDI) and adverse drug reactions (ADR) in older adults polymedicated. METHODS: an integrative review of studies published from January 2008 to December 2013, according to inclusion and exclusion criteria, in MEDLINE and EMBASE electronic databases were performed. RESULTS: forty-seven full-text studies including 14,624,492 older adults (≥ 60 years) were analyzed: 24 (51...
2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27232130/invasion-of-rural-houses-by-wild-triatominae-in-the-arid-chaco
#6
María J Cavallo, Ivana Amelotti, David E Gorla
Triatomines are the vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease, the main endemic disease affecting five to seven million people in Latin America. Besides Triatoma infestans, the most important T. cruzi vector in the Gran Chaco region, other triatomine species associated with sylvatic birds and mammals are responsible for the maintenance of the wild cycle of T. cruzi. The present study aimed at evaluating the house invasion by sylvatic triatomine species in rural communities of the Los Llanos region (La Rioja, Argentina) and its association with environmental variables...
June 2016: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/27198794/potential-role-for-mucosal-iga-in-modulating-haemonchus-contortus-adult-worm-infection-in-sheep
#7
J N Hernández, A Hernández, M J Stear, M Conde-Felipe, E Rodríguez, D Piedrafita, J F González
Haemonchus contortus (H. contortus) is a haematophagous parasite which causes important economic losses in small ruminants. On the island of Gran Canaria, two sheep breeds coexist which differ in their susceptibility to the infection with H. contortus; the resistant Canaria Hair Breed (CHB) sheep and the susceptible Canaria Sheep (CS) breed. The major target of resistance mechanisms in CHB sheep are directed to the adult parasite stage, reducing the worm burden, and decreased length and fecundity of surviving worms...
June 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27096633/influence-of-parasitism-in-dogs-on-their-serum-levels-of-persistent-organochlorine-compounds-and-polycyclic-aromatic-hydrocarbons
#8
Luis A Henríquez-Hernández, Elena Carretón, María Camacho, José Alberto Montoya-Alonso, Luis D Boada, Pilar F Valerón, Yaiza Falcón Cordón, Maira Almeida-González, Manuel Zumbado, Octavio P Luzardo
Persistent organochlorine pollutants (POPs) are toxic chemicals, which accumulate in humans and animals, as only few species have the capability of eliminating them. However, some authors have pointed to the possibility that certain species of invertebrates (i.e. nematodes) could metabolize this type of compounds. As certain species of nematodes act as parasites of vertebrates, this research was designed to explore the influence of some of the most common parasites of the dogs in their serum levels of 56 common POPs...
August 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26866695/characterization-of-regulatory-t-cell-markers-in-cd4-t-cells-of-the-upper-airway-mucosa
#9
Christina Ballke, Einar Gran, Espen S Baekkevold, Frode L Jahnsen
CD4+ T regulatory cells (Tregs) comprise a heterogeneous population of cells the regulate immune responses and prevent autoimmunity. Most reports on human Tregs are derived from studies of peripheral blood, although Tregs mainly exert their functions in the periphery. Here we performed a detailed analysis of Tregs in the human upper airway mucosa under non-inflammatory conditions, and found that 10% of all CD4+ T cells expressed the transcription factor FOXP3 and the memory marker CD45RO, as well as high levels of CTLA-4...
2016: PloS One
https://www.readbyqxmd.com/read/26708994/a-comparative-study-of-trypanosoma-cruzi-infection-in-sylvatic-mammals-from-a-protected-and-a-disturbed-area-in-the-argentine-chaco
#10
COMPARATIVE STUDY
M M Orozco, G F Enriquez, M V Cardinal, R V Piccinali, R E Gürtler
Understanding the complex epidemiology of Trypanosoma cruzi transmission cycles requires comparative studies in widely different environments. We assessed the occurrence of T. cruzi infection in sylvatic mammals, their infectiousness to the vector, and parasite genotypes in a protected area of the Argentine Chaco, and compared them with information obtained similarly in a nearby disturbed area. A total of 278 mammals from >23 species in the protected area were diagnosed for T. cruzi infection using xenodiagnosis, kDNA-PCR and nuclear satellite DNA-PCR (SAT) from blood samples...
March 2016: Acta Tropica
https://www.readbyqxmd.com/read/26386212/maternal-inheritance-does-not-predict-cholesterol-levels-in-children-with-familial-hypercholesterolemia
#11
Ingunn Narverud, Jeanine Roeters van Lennep, Jacob J Christensen, Jorie Versmissen, Jon Michael Gran, Per Ole Iversen, Pål Aukrust, Bente Halvorsen, Thor Ueland, Stine M Ulven, Leiv Ose, Marit B Veierød, Eric Sijbrands, Kjetil Retterstøl, Kirsten B Holven
BACKGROUND AND AIMS: Pregnancy exerts metabolic changes with increasing levels of total cholesterol and triglycerides as prominent features. Maternal hypercholesterolemia may thus contribute to an unfavorable in utero environment potentially influencing the susceptibility of adult cardiovascular disease in the offspring. We investigated the impact of maternal familial hypercholesterolemia (FH) on pre-treatment plasma lipids and C-reactive protein (CRP) levels in non-statin treated FH children...
November 2015: Atherosclerosis
https://www.readbyqxmd.com/read/26382746/fear-of-childbirth-and-elective-caesarean-section-a-population-based-study
#12
Hege Therese Størksen, Susan Garthus-Niegel, Samantha S Adams, Siri Vangen, Malin Eberhard-Gran
BACKGROUND: This population-based cohort study aimed to investigate the demographic and psychosocial characteristics associated with fear of childbirth and the relative importance of such fear as a predictor of elective caesarean section. METHODS: A sample of 1789 women from the Akershus Birth Cohort in Norway provided data collected by three self-administered questionnaires at 17 and 32 weeks of pregnancy and 8 weeks postpartum. Information about the participants' childbirths was obtained from the hospital records...
2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26180162/echocardiography-in-the-assessment-of-left-atrial-pressure-after-pediatric-heart-surgery-a-comparison-study-with-measurements-obtained-from-left-atrial-catheter
#13
Marc Figueras-Coll, Joan Sanchez-de-Toledo, Ferran Gran, Raul Abella, Santiago Perez-Hoyos, Ferran Rosés
BACKGROUND: Correlation between ventricular end-diastolic pressure and pulsed Doppler and tissue Doppler-derived E/e' ratio has been widely reported in adults but scarcely studied in children with congenital heart diseases. This ratio is defined as the relationship between diastolic transmitral flow velocity (cm/s; E) and myocardial diastolic relaxation velocity (cm/s; e') in the lateral aspect of the mitral annulus. Our main objective was to ascertain whether a correlation existed between direct measurement of left atrial pressure and echocardiographic E/e' ratio in children after heart surgery...
July 2015: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/26134933/detection-of-lyme-disease-and-q-fever-agents-in-wild-rodents-in-central-italy
#14
Ilaria Pascucci, Marco Di Domenico, Francesca Dall'Acqua, Giulia Sozio, Cesare Cammà
The maintenance of tick-borne disease agents in the environment strictly depends on the relationship between tick vectors and their hosts, which act as reservoirs for these pathogens. A pilot study aimed to investigate wild rodents as reservoirs for zoonotic tick-borne pathogens (Borrelia burgdorferi sensu lato (s.l.), Coxiella burnetii, Francisella tularensis, and Anaplasma phagocytophilum) was carried out in an area of Gran Sasso e Monti della Laga National Park (Abruzzi Region, central Italy), a wide protected area where, despite sporadic reports of infection in humans and animals, eco-epidemiological data on these diseases are still not available...
July 2015: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/25993914/sterilization-of-polydimethylsiloxane-surface-with-chinese-herb-extract-a-new-antibiotic-mechanism-of-chlorogenic-acid
#15
Song Ren, Ming Wu, Jiayu Guo, Wang Zhang, Xiaohan Liu, Lili Sun, Robert Holyst, Sen Hou, Yongchun Fang, Xizeng Feng
Coating of polydimethylsiloxane (PDMS) surface with a traditional Chinese herb extract chlorogenic acid (CA) solves the contemporary problem of sterilization of PDMS surface. The E. coli grows slower and has a higher death rate on the CA-coated PDMS surfaces. A smoother morphology of these E. coli cell wall is observed by atomic force microscopy (AFM). Unlike the reported mechanism, where CA inhibits bacterial growth by damaging the cell membrane in the bulk solution, we find the CA-coated PDMS surface also decreases the stiffness of the cell wall...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25662814/persistent-extended-spectrum-%C3%AE-lactamase-positive-escherichia-coli-chronic-prostatitis-successfully-treated-with-a-combination-of-fosfomycin-and-doxycycline
#16
Burke A Cunha, Arthur Gran, Muhammad Raza
For chronic bacterial prostatitis, there are few oral antibiotics available that are active against common uropathogens and are able to penetrate the non-inflamed prostate at therapeutic concentrations. Oral options to treat chronic prostatitis due to Gram-negative bacillary multidrug-resistant organisms are even more limited. We report a case of persistent extended-spectrum β-lactamase (ESBL)-positive Escherichia coli chronic prostatitis refractory to antibiotic therapy. Prolonged courses of fosfomycin failed to eradicate the infection...
April 2015: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/25579426/trypanosoma-cruzi-infection-in-triatoma-sordida-before-and-after-community-wide-residual-insecticide-spraying-in-the-argentinean-chaco
#17
Natalia P Macchiaverna, María S Gaspe, Gustavo F Enriquez, Laura Tomassone, Ricardo E Gürtler, Marta V Cardinal
Triatoma sordida is a secondary vector of Trypanosoma cruzi in the Gran Chaco and Cerrado eco-regions where it frequently infests peridomestic and domestic habitats. In a well-defined area of the humid Argentine Chaco, very few T. sordida were found infected when examined by optical microscopic examination (OM). In order to further assess the role of T. sordida and the relative magnitude of subpatent bug infections, we examined the insects for T. cruzi infection, parasite Discrete Typing Units (DTUs) and bloodmeal sources using various molecular techniques...
March 2015: Acta Tropica
https://www.readbyqxmd.com/read/25385993/brenneria-populi-sp-nov-isolated-from-symptomatic-bark-of-populus%C3%A3-euramericana-canker
#18
Yong Li, Wei Fang, Han Xue, Wen-Xing Liang, Lai-Fa Wang, Guo-Zhong Tian, Xi-Zhuo Wang, Cai-Li Lin, Xia Li, Chun-Gen Piao
Five Gran-stain-negative, facultatively anaerobic, motile, bacterial strains were isolated from symptomatic bark tissue of Populus×euramericana canker. Strains grew at 4-41 °C, pH 4-10 and 0-6 % (w/v) salinity. They were positive with respect to catalase activity and negative for oxidase activity, nitrate reduction and the Voges-Proskauer reaction. Analysis of 16S rRNA gene sequences indicated that these five poplar isolates belong to the genus Brenneria, having highest sequence similarity of 95.98 % with Brenneria goodwinii LMG 26270(T)...
February 2015: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/25182013/earthquakes-trigger-the-loss-of-groundwater-biodiversity
#19
Diana M P Galassi, Paola Lombardo, Barbara Fiasca, Alessia Di Cioccio, Tiziana Di Lorenzo, Marco Petitta, Piero Di Carlo
Earthquakes are among the most destructive natural events. The 6 April 2009, 6.3-Mw earthquake in L'Aquila (Italy) markedly altered the karstic Gran Sasso Aquifer (GSA) hydrogeology and geochemistry. The GSA groundwater invertebrate community is mainly comprised of small-bodied, colourless, blind microcrustaceans. We compared abiotic and biotic data from two pre-earthquake and one post-earthquake complete but non-contiguous hydrological years to investigate the effects of the 2009 earthquake on the dominant copepod component of the obligate groundwater fauna...
2014: Scientific Reports
https://www.readbyqxmd.com/read/25138406/-a-man-in-his-forties-with-swelling-in-both-orbits
#20
Øyvind Midtvedt, Jan Tore Gran, Hanne Solheim, Eva Kirkhus, Signe Spetalen
UNLABELLED: Erdheim-Chester disease. A multi-disiplinary challenge. The histiocytoses are a diverse, but rare group of disorders with symptoms affecting many organs, varying from self-limiting, localised lesions to disseminated multi-organ disease. The diagnostic challenges are illustrated and discussed in the following case. CASE REPORT: A man in his forties was admitted to hospital due to pain in his right eye and visual disturbances. MRI imaging detected a mass in his right orbit and a minor mass in his left orbit...
August 19, 2014: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
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