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https://www.readbyqxmd.com/read/29065449/chronic-venous-insufficiency-transforming-growth-factor-%C3%AE-isoforms-and-soluble-endoglin-concentration-in-different-states-of-wound-healing
#1
Daniela Ligi, Lidia Croce, Giovanni Mosti, Joseph D Raffetto, Ferdinando Mannello
Venous leg ulcer (VLU) is a huge healthcare problem with poorly understood pathophysiology. Transforming growth factor-β (TGF-β) and endoglin (Eng), are inflammatory and wound healing mediators. Eng, co-receptor for TGF-β type-II receptors, may be cleaved forming soluble Eng (sEng), antagonizing TGF-β signaling, a crucial process in vascular pathologies. We evaluated the accumulation in wound fluid (WF) of TGF-β isoforms and sEng in healing stages, showing the effects of sulodexide treatments, a glycosaminoglycan with clinical efficacy in VLU healing...
October 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28894442/isolation-and-characterization-of-phenanthrene-degrading-bacteria-from-diesel-fuel-contaminated-antarctic-soils
#2
Alejandro Gran-Scheuch, Edwar Fuentes, Denisse M Bravo, Juan Cristobal Jiménez, José M Pérez-Donoso
Antarctica is an attractive target for human exploration and scientific investigation, however the negative effects of human activity on this continent are long lasting and can have serious consequences on the native ecosystem. Various areas of Antarctica have been contaminated with diesel fuel, which contains harmful compounds such as heavy metals and polycyclic aromatic hydrocarbons (PAH). Bioremediation of PAHs by the activity of microorganisms is an ecological, economical, and safe decontamination approach...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28766791/symptom-burden-and-patient-characteristics-association-with-quality-of-life-in-patients-with-head-and-neck-cancer-undergoing-radiotherapy
#3
Guro Lindviksmoen Astrup, Tone Rustøen, Kristin Hofsø, Jon Michael Gran, Kristin Bjordal
BACKGROUND: Patients with head and neck cancer (HNC) experience diminished quality of life (QOL) during and after treatment. This study examined which characteristics were associated with QOL over time. METHODS: One hundred thirty-three patients with HNC from a study of 534 oncology patients rated physical and mental QOL using the Short Form-12 5 times from the initiation of radiotherapy (RT) through the following 6 months. Linear mixed model analyses examined changes over time and associated characteristics...
October 2017: Head & Neck
https://www.readbyqxmd.com/read/28724645/effect-of-maternal-high-dosages-of-folic-acid-supplements-on-neurocognitive-development-in-children-at-4-5-y-of-age-the-prospective-birth-cohort-infancia-y-medio-ambiente-inma-study
#4
MULTICENTER STUDY
Desirée Valera-Gran, Eva M Navarrete-Muñoz, Manuela Garcia de la Hera, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea, Nekane Balluerka, Mario Murcia, Llúcia González-Safont, Dora Romaguera, Jordi Julvez, Jesús Vioque
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 μg/d) on child neurocognitive outcomes.Objective: The objective of the study was to examine the association between the use of high dosages of FASs during pregnancy and child neuropsychological development at ages 4-5 y...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28688631/are-early-physical-activity-and-sedentary-behaviors-related-to-working-memory-at-7-and-14-years-of-age
#5
Mónica López-Vicente, Judith Garcia-Aymerich, Jaume Torrent-Pallicer, Joan Forns, Jesús Ibarluzea, Nerea Lertxundi, Llúcia González, Desirée Valera-Gran, Maties Torrent, Payam Dadvand, Martine Vrijheid, Jordi Sunyer
OBJECTIVE: To evaluate the role of extracurricular physical activity and sedentary behavior at preschool and primary school age on working memory at primary school age and adolescence, respectively. STUDY DESIGN: This prospective study was based on a birth cohort across 4 Spanish regions. In the 3 younger subcohorts (n = 1093), parents reported lifestyle habits of child at age 4 years of age on a questionnaire, and children performed a computerized working memory task at 7 years of age...
September 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28388824/conservation-strategies-for-understanding-and-combating-the-primate-bushmeat-trade-on-bioko-island-equatorial-guinea
#6
REVIEW
Drew T Cronin, Paul R Sesink Clee, Matthew W Mitchell, Demetrio Bocuma Meñe, David Fernández, Cirilo Riaco, Maximiliano Fero Meñe, Jose Manuel Esara Echube, Gail W Hearn, Mary Katherine Gonder
Bioko Island, Equatorial Guinea is among the important places in Africa for the conservation of primates, but a cultural preference for bushmeat and a lack of effective law enforcement has encouraged commercial bushmeat hunting, threatening the survival of the remaining primate population. For over 13 years, we collected bushmeat market data in the Malabo market, recording over 35,000 primate carcasses, documenting "mardi gras" consumption patterns, seasonal carcass availability, and negative effects resulting from government intervention...
November 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28367377/expression-and-clinical-value-of-egfr-in-human-meningiomas
#7
Magnus B Arnli, Thomas Backer-Grøndahl, Borgny Ytterhus, Unn S Granli, Stian Lydersen, Sasha Gulati, Sverre H Torp
BACKGROUND: Meningiomas are common intracranial tumors in humans that frequently recur despite having a predominantly benign nature. Even though these tumors have been shown to commonly express EGFR/c-erbB1 (epidermal growth factor receptor), results from previous studies are uncertain regarding the expression of either intracellular or extracellular domains, cellular localization, activation state, relations to malignancy grade, and prognosis. AIMS: This study was designed to investigate the expression of the intracellular and extracellular domains of EGFR and of the activated receptor as well as its ligands EGF and TGFα in a large series of meningiomas with long follow-up data, and investigate if there exists an association between antibody expression and clinical and histological data...
2017: PeerJ
https://www.readbyqxmd.com/read/28301557/a-screening-questionnaire-for-convulsive-seizures-a-three-stage-field-validation-in-rural-bolivia
#8
Loretta Giuliano, Calogero Edoardo Cicero, Elizabeth Blanca Crespo Gómez, Sandra Padilla, Elisa Bruno, Mario Camargo, Benoit Marin, Vito Sofia, Pierre-Marie Preux, Marianne Strohmeyer, Alessandro Bartoloni, Alessandra Nicoletti
INTRODUCTION: Epilepsy is one of the most common neurological diseases in Latin American Countries (LAC) and epilepsy associated with convulsive seizures is the most frequent type. Therefore, the detection of convulsive seizures is a priority, but a validated Spanish-language screening tool to detect convulsive seizures is not available. We performed a field validation to evaluate the accuracy of a Spanish-language questionnaire to detect convulsive seizures in rural Bolivia using a three-stage design...
2017: PloS One
https://www.readbyqxmd.com/read/28101997/the-ecology-of-anemia-anemia-prevalence-and-correlated-factors-in-adult-indigenous-women-in-argentina
#9
Laura G Goetz, Claudia Valeggia
OBJECTIVES: The Toba/Qom of Namqom are an indigenous community native to the Gran Chaco region of northern Argentina. Historically seminomadic foragers, the diet of peri-urban community members has rapidly changed from high-protein, high-fiber to hypercaloric, processed. This study aims to understand the impact of this nutritional transition on aspects of women's health by exploring the relationship between prevalence of anemia and current diet composition, place of birth, and reproductive history...
January 19, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27833157/association-between-the-p-thr1406asn-polymorphism-of-the-carbamoyl-phosphate-synthetase-1-gene-and-necrotizing-enterocolitis-a-prospective-multicenter-study
#10
Rob M Moonen, Giacomo Cavallaro, Maurice J Huizing, Gema E González-Luis, Fabio Mosca, Eduardo Villamor
The p.Thr1406Asn (rs1047891) polymorphism of the carbamoyl-phosphate synthetase 1 (CPS1) gene has been linked to functional consequences affecting the downstream availability of the nitric oxide precursor L-arginine. L-arginine concentrations are decreased in preterm infants with necrotizing enterocolitis (NEC). In this multicenter prospective study, we investigated the association of the p.Thr1406Asn polymorphism with NEC in 477 preterm infants (36 cases of NEC) from 4 European neonatal intensive care units (Maastricht, Las Palmas de Gran Canaria, Mantova, and Milan)...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27762063/peritoneal-dialysis-in-patients-with-failed-kidney-transplant-single-centre-experience
#11
Saurabh Chaudhri, Alice A Thomas, Nasreen Samad, Stanley L Fan
AIM: To determine if patients with failing kidney transplants who opt to have peritoneal dialysis (PD) have poor short-term PD technique survival and increased rates of peritonitis. METHODS: We performed a retrospective analysis comparing 50 consecutive patients starting PD after a failed kidney transplant to 93 incident patients starting PD (matching for age, gender, diabetes causing renal failure, ethnicity and year of starting PD). RESULTS: The mean follow-up period was 26 months...
October 20, 2016: Nephrology
https://www.readbyqxmd.com/read/27760419/relationship-between-anemia-and-serum-concentrations-of-calcium-and-phosphorus-in-advanced-non-dialysis-dependent-chronic-kidney-disease
#12
Mauro Boronat, Ángelo Santana, Elvira Bosch, Dionisio Lorenzo, Marta Riaño, César García-Cantón
BACKGROUND/AIMS: Different biochemical abnormalities of metabolic bone disease have been associated with anemia of chronic kidney disease (CKD), mainly in hemodialysis patients. However, all of these abnormalities are closely inter-related and their individual effect on the development of anemia is uncertain. This study was aimed to assess the relationship between anemia and a set of metabolic bone disease biomarkers in a cohort of adult patients with advanced non-dialysis-dependent CKD...
2017: Nephron
https://www.readbyqxmd.com/read/27751690/the-heartworm-dirofilaria-immitis-seems-to-be-able-to-metabolize-organochlorine-pesticides-and-polychlorinated-biphenyls-a-case-control-study-in-dogs
#13
Luis A Henríquez-Hernández, Elena Carretón, María Camacho, José Alberto Montoya-Alonso, Luis D Boada, Pilar F Valerón, Yaiza Falcón-Cordón, Soraya Falcón-Cordón, Maira Almeida-González, Manuel Zumbado, Octavio P Luzardo
It has been described that the co-existence of parasite infection and chemical exposure has various effects on the accumulation of persistent organochlorine pollutants (POPs) in the host. Certain parasites are not only able to accumulate POPs but also seem to have the ability to metabolize certain compounds. We have designed a case-control study aimed to disclose the role of Dirofilaria immitis in the bioavailability of POPs in dogs trying to know whether these parasites store or metabolize the POPs. A total of 40 common POPs (18 polychlorinated biphenyls congeners (PCBs) and 22 organochlorine pesticides were quantified in dog serum...
January 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27598380/drug-drug-interactions-and-adverse-drug-reactions-in-polypharmacy-among-older-adults-an-integrative-review
#14
Maria Cristina Soares Rodrigues, Cesar de Oliveira
OBJECTIVE: to identify and summarize studies examining both drug-drug interactions (DDI) and adverse drug reactions (ADR) in older adults polymedicated. METHODS: an integrative review of studies published from January 2008 to December 2013, according to inclusion and exclusion criteria, in MEDLINE and EMBASE electronic databases were performed. RESULTS: forty-seven full-text studies including 14,624,492 older adults (≥ 60 years) were analyzed: 24 (51...
September 1, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27232130/invasion-of-rural-houses-by-wild-triatominae-in-the-arid-chaco
#15
María J Cavallo, Ivana Amelotti, David E Gorla
Triatomines are the vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease, the main endemic disease affecting five to seven million people in Latin America. Besides Triatoma infestans, the most important T. cruzi vector in the Gran Chaco region, other triatomine species associated with sylvatic birds and mammals are responsible for the maintenance of the wild cycle of T. cruzi. The present study aimed at evaluating the house invasion by sylvatic triatomine species in rural communities of the Los Llanos region (La Rioja, Argentina) and its association with environmental variables...
June 2016: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/27198794/potential-role-for-mucosal-iga-in-modulating-haemonchus-contortus-adult-worm-infection-in-sheep
#16
J N Hernández, A Hernández, M J Stear, M Conde-Felipe, E Rodríguez, D Piedrafita, J F González
Haemonchus contortus (H. contortus) is a haematophagous parasite which causes important economic losses in small ruminants. On the island of Gran Canaria, two sheep breeds coexist which differ in their susceptibility to the infection with H. contortus; the resistant Canaria Hair Breed (CHB) sheep and the susceptible Canaria Sheep (CS) breed. The major target of resistance mechanisms in CHB sheep are directed to the adult parasite stage, reducing the worm burden, and decreased length and fecundity of surviving worms...
June 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27096633/influence-of-parasitism-in-dogs-on-their-serum-levels-of-persistent-organochlorine-compounds-and-polycyclic-aromatic-hydrocarbons
#17
Luis A Henríquez-Hernández, Elena Carretón, María Camacho, José Alberto Montoya-Alonso, Luis D Boada, Pilar F Valerón, Yaiza Falcón Cordón, Maira Almeida-González, Manuel Zumbado, Octavio P Luzardo
Persistent organochlorine pollutants (POPs) are toxic chemicals, which accumulate in humans and animals, as only few species have the capability of eliminating them. However, some authors have pointed to the possibility that certain species of invertebrates (i.e. nematodes) could metabolize this type of compounds. As certain species of nematodes act as parasites of vertebrates, this research was designed to explore the influence of some of the most common parasites of the dogs in their serum levels of 56 common POPs...
August 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26866695/characterization-of-regulatory-t-cell-markers-in-cd4-t-cells-of-the-upper-airway-mucosa
#18
Christina Ballke, Einar Gran, Espen S Baekkevold, Frode L Jahnsen
CD4+ T regulatory cells (Tregs) comprise a heterogeneous population of cells the regulate immune responses and prevent autoimmunity. Most reports on human Tregs are derived from studies of peripheral blood, although Tregs mainly exert their functions in the periphery. Here we performed a detailed analysis of Tregs in the human upper airway mucosa under non-inflammatory conditions, and found that 10% of all CD4+ T cells expressed the transcription factor FOXP3 and the memory marker CD45RO, as well as high levels of CTLA-4...
2016: PloS One
https://www.readbyqxmd.com/read/26708994/a-comparative-study-of-trypanosoma-cruzi-infection-in-sylvatic-mammals-from-a-protected-and-a-disturbed-area-in-the-argentine-chaco
#19
COMPARATIVE STUDY
M M Orozco, G F Enriquez, M V Cardinal, R V Piccinali, R E Gürtler
Understanding the complex epidemiology of Trypanosoma cruzi transmission cycles requires comparative studies in widely different environments. We assessed the occurrence of T. cruzi infection in sylvatic mammals, their infectiousness to the vector, and parasite genotypes in a protected area of the Argentine Chaco, and compared them with information obtained similarly in a nearby disturbed area. A total of 278 mammals from >23 species in the protected area were diagnosed for T. cruzi infection using xenodiagnosis, kDNA-PCR and nuclear satellite DNA-PCR (SAT) from blood samples...
March 2016: Acta Tropica
https://www.readbyqxmd.com/read/26386212/maternal-inheritance-does-not-predict-cholesterol-levels-in-children-with-familial-hypercholesterolemia
#20
Ingunn Narverud, Jeanine Roeters van Lennep, Jacob J Christensen, Jorie Versmissen, Jon Michael Gran, Per Ole Iversen, Pål Aukrust, Bente Halvorsen, Thor Ueland, Stine M Ulven, Leiv Ose, Marit B Veierød, Eric Sijbrands, Kjetil Retterstøl, Kirsten B Holven
BACKGROUND AND AIMS: Pregnancy exerts metabolic changes with increasing levels of total cholesterol and triglycerides as prominent features. Maternal hypercholesterolemia may thus contribute to an unfavorable in utero environment potentially influencing the susceptibility of adult cardiovascular disease in the offspring. We investigated the impact of maternal familial hypercholesterolemia (FH) on pre-treatment plasma lipids and C-reactive protein (CRP) levels in non-statin treated FH children...
November 2015: Atherosclerosis
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