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gestational diabetes AND malformations

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https://www.readbyqxmd.com/read/27798989/maternal-environmental-risk-factors-for-congenital-hydrocephalus-a-systematic-review
#1
Aristotelis V Kalyvas, Theodosis Kalamatianos, Mantha Pantazi, Georgios D Lianos, George Stranjalis, George A Alexiou
OBJECTIVE Congenital hydrocephalus (CH) is one of the most frequent CNS congenital malformations, representing an entity with serious pathological consequences. Although several studies have previously assessed child-related risk factors associated with CH development, there is a gap of knowledge on maternal environmental risk factors related to CH. The authors have systematically assessed extrinsic factors in the maternal environment that potentially confer an increased risk of CH development. METHODS The Cochrane Library, MEDLINE, and EMBASE were systematically searched for works published between 1966 and December 2015 to identify all relevant articles published in English...
November 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27743975/preconceptional-and-maternal-obesity-epidemiology-and-health-consequences
#2
REVIEW
Lucilla Poston, Rishi Caleyachetty, Sven Cnattingius, Camila Corvalán, Ricardo Uauy, Sharron Herring, Matthew W Gillman
Obesity in women of reproductive age is increasing in prevelance worldwide. Obesity reduces fertility and increases time taken to conceive, and obesity-related comorbidities (such as type 2 diabetes and chronic hypertension) heighten the risk of adverse outcomes for mother and child if the woman becomes pregnant. Pregnant women who are obese are more likely to have early pregnancy loss, and have increased risk of congenital fetal malformations, delivery of large for gestational age infants, shoulder dystocia, spontaneous and medically indicated premature birth, and stillbirth...
December 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27704220/a-review-of-the-safety-of-clozapine-during-pregnancy-and-lactation
#3
Taylor M Mehta, Ryan J Van Lieshout
Clozapine is an antipsychotic used in the management of treatment-resistant schizophrenia. However, little is known about clozapine use during pregnancy and lactation, or its impact on the mother, foetus, and infant. This review aims to summarize the available literature on the safety of clozapine use during the perinatal period. EMBASE, PsycINFO, and MEDLINE were searched from their inceptions through June 2016. The review encompasses 21 studies that have examined clozapine use during pregnancy and lactation...
October 4, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27620916/adverse-obstetric-outcomes-associated-with-in-vitro-fertilization-in-singleton-pregnancies-a-prospective-cohort-study
#4
Jiabi Qin, Xiaoqi Sheng, Di Wu, Shiyou Gao, Yiping You, Tubao Yang, Hua Wang
OBJECTIVE: To compare the obstetric outcomes of women treated with in vitro fertilization (IVF), women with indicators of subfertility but without assisted reproductive technologies, and fertile women with singleton pregnancies. METHODS: A prospective cohort study was conducted from March 2013 to February 2016 at the Hunan Provincial Maternal and Child Health Hospital in China. Finally, 1260 eligible mothers were recruited into the IVF group, 1899 into the subfertile group, and 2480 into the fertile group...
September 11, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27603343/effects-of-metformin-on-pregnancy-outcomes-in-women-with-polycystic-ovary-syndrome-a-meta-analysis
#5
Xian-Ling Zeng, Ya-Fei Zhang, Quan Tian, Yan Xue, Rui-Fang An
AIM: The aim of the study is to evaluate the effects of metformin on pregnancy outcomes in women with polycystic ovary syndrome (PCOS). METHODS: We searched electronic databases and bibliographies of relevant papers to identify studies comparing the pregnancy outcomes in the metformin group with those in the placebo or blank control group. Then, we did this meta-analysis based on the PRISMA guidelines. The primary outcomes included early pregnancy loss (EPL), preterm delivery, term delivery, and gestational diabetes mellitus (GDM)...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27593528/impact-of-type-2-diabetes-obesity-and-glycaemic-control-on-pregnancy-outcomes
#6
Sally K Abell, Jacqueline A Boyle, Barbora de Courten, Georgia Soldatos, Euan M Wallace, Sophia Zoungas, Helena J Teede
BACKGROUND: There are no contemporary cohorts examining pregnancy outcomes in women with type 2 diabetes (T2D) in Australia. AIM: To compare pregnancy outcomes in women with and without T2D, and assess effects of body mass index (BMI) and glycaemic control on outcomes. MATERIALS AND METHODS: An historical cohort study was conducted of all singleton births > 20 weeks gestation at a specialist maternity network in Australia from 2010 to 2013...
September 5, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27590958/outcomes-of-offspring-born-to-mothers-with-gestational-diabetes
#7
Noel Pratheepan Somasundaram, Chandrika Jayakanthi Subasinghe, Wickrama Kankanamge Maheshi Gimhani Amarawardena
With the global explosion of Diabetes and obesity at epidemic proportions, keeping Asia at its epicenter, 1 in 7 live births get complicated with hyperglycaemia; either pre-existing Diabetes or Gestational Diabetes. In utero, exposure to an adverse metabolic environment with nutrient excess or deficiencies and toxic metabolites with teratogenic potential, leads to short and long term consequences to the offspring. Multisystemic congenital malformations, macrosomia associated obstetric complications and perinatal metabolic derangements complicate the early neonatal stage...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27590955/neonatal-management-of-pregnancy-complicated-by-diabetes
#8
Fauzia Mohsin, Shareen Khan, Md Abdul Baki, Bedowra Zabeen, Kiswhar Azad
Women with diabetes in pregnancy, either pre-gestational Diabetes Mellitus (Type 1 & Type 2) or Gestational Diabetes, are at increased risk for adverse pregnancy outcomes, including preterm labour and increased foetal mortality rate. Adequate glycaemic control before and during pregnancy is crucial for improving foetal and perinatal outcomes in these babies. Perinatal and neonatal morbidities and mortality rates have declined since the development of specialized maternal, foetal, and neonatal care for women with diabetes and their offspring...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27590953/first-trimester-complications-in-pregnancy-with-diabetes
#9
Bishwajit Bhowmik
Diabetes is the most prevalent medical condition complicating pregnancy in the world. It carries both acute and long-term health consequences for the mother and her offspring. Both preexisting (type 1 and type 2) and gestational diabetes are a high-risk state for miscarriage, stillbirths and congenital malformations in early pregnancy. Like normal pregnancy, vaginal bleeding, urinary tract infection, abdominopelvic pain, nausea, and vomiting are common presenting symptoms in early pregnancy with preexisting and gestational diabetes...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27582165/outcomes-of-offspring-born-to-mothers-with-gestational-diabetes
#10
Noel Pratheepan Somasundaram, Chandrika Jayakanthi Subasinghe, Wickrama Kankanamge Maheshi Gimhani Amarawardena
With the global explosion of Diabetes and obesity at epidemic proportions, keeping Asia at its epicenter, 1 in 7 live births get complicated with hyperglycaemia; either pre-existing Diabetes or Gestational Diabetes. In utero, exposure to an adverse metabolic environment with nutrient excess or deficiencies and toxic metabolites with teratogenic potential, leads to short and long term consequences to the offspring. Multisystemic congenital malformations, macrosomia associated obstetric complications and perinatal metabolic derangements complicate the early neonatal stage...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27582162/neonatal-management-of-pregnancy-complicated-by-diabetes
#11
Fauzia Mohsin, Shareen Khan, Md Abdul Baki, Bedowra Zabeen, Kiswhar Azad
Women with diabetes in pregnancy, either pre-gestational Diabetes Mellitus (Type 1 & Type 2) or Gestational Diabetes, are at increased risk for adverse pregnancy outcomes, including preterm labour and increased foetal mortality rate. Adequate glycaemic control before and during pregnancy is crucial for improving foetal and perinatal outcomes in these babies. Perinatal and neonatal morbidities and mortality rates have declined since the development of specialized maternal, foetal, and neonatal care for women with diabetes and their offspring...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27582160/first-trimester-complications-in-pregnancy-with-diabetes
#12
Bishwajit Bhowmik
Diabetes is the most prevalent medical condition complicating pregnancy in the world. It carries both acute and long-term health consequences for the mother and her offspring. Both preexisting (type 1 and type 2) and gestational diabetes are a high-risk state for miscarriage, stillbirths and congenital malformations in early pregnancy. Like normal pregnancy, vaginal bleeding, urinary tract infection, abdominopelvic pain, nausea, and vomiting are common presenting symptoms in early pregnancy with preexisting and gestational diabetes...
September 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27535646/investigating-susceptibility-to-diabetes-using-features-of-the-adipose-tissue-in-response-to-in-utero-polycyclic-aromatic-hydrocarbons-exposure
#13
Worlanyo E Gato, Daniel A Hunter, Shamaya L Whitby, Christopher A Mays, Wilson Yau
BACKGROUND: In recent times, there has been an increase in the incidence of type 2 diabetes mellitus (T2DM) particularly in children. Adipocyte dysfunction provide a critical link between obesity and insulin resistance resulting in diabetes outcome. Further, environmental chemical exposure during early years of life might be a significant contributing factor to the increase in the incidence of T2DM. This study tests the idea that exposure to environmental contaminants (2-aminoanthracene [2AA]) in utero will show effects in the adipose tissue (AT) that signify T2DM vulnerability...
August 12, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27533763/inflammatory-and-oxidative-stress-airway-markers-in-premature-newborns-of-hypertensive-mothers
#14
R J Madoglio, L M S S Rugolo, C S Kurokawa, M P A Sá, J C Lyra, L C O Antunes
Although oxidative stress and inflammation are important mechanisms in the pathophysiology of preeclampsia and preterm diseases, their contribution to the respiratory prognosis of premature infants of hypertensive mothers is not known. Our objective was to determine the levels of oxidative stress and inflammation markers in the airways of premature infants born to hypertensive and normotensive mothers, in the first 72 h of life, and to investigate whether they are predictors of bronchopulmonary dysplasia (BPD)/death...
August 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27510344/contemporary-type-1-diabetes-pregnancy-outcomes-impact-of-obesity-and-glycaemic-control
#15
Sally K Abell, Jacqueline A Boyle, Barbora de Courten, Michelle Knight, Sanjeeva Ranasinha, John Regan, Georgia Soldatos, Euan M Wallace, Sophia Zoungas, Helena J Teede
OBJECTIVE: To compare contemporary pregnancy outcomes in women with and without type 1 diabetes, and to examine the effects of obesity and glycaemic control on these outcomes. DESIGN AND SETTING: Historical cohort study in a specialist diabetes and maternity network in Victoria. PARTICIPANTS: All singleton births (at least 20 weeks' gestation), 2010-2013, were analysed: 107 pregnancies to women with type 1 diabetes and 27 075 pregnancies to women without diabetes...
August 15, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27484686/risks-associated-with-antipsychotic-treatment-in-pregnancy-comparative-cohort-studies-based-on-electronic-health-records
#16
Irene Petersen, Cormac J Sammon, Rachel L McCrea, David P J Osborn, Stephen J Evans, Phillip J Cowen, Irwin Nazareth
BACKGROUND: Limited information is available on whether antipsychotics prescribed in pregnancy are associated with increased risks of adverse outcomes. METHODS: We used electronic health records from pregnant women and their children to examine risks of adverse maternal and child outcomes in three cohorts of women who: (A) received antipsychotic treatment in pregnancy (n=416) (B) discontinued antipsychotic treatment before pregnancy (n=670), and (C) had no records of antipsychotic treatment before or during pregnancy (n=318,434)...
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27443814/associations-between-maternal-periconceptional-exposure-to-secondhand-tobacco-smoke-and-major-birth-defects
#17
Adrienne T Hoyt, Mark A Canfield, Paul A Romitti, Lorenzo D Botto, Marlene T Anderka, Sergey V Krikov, Morgan K Tarpey, Marcia L Feldkamp
BACKGROUND: While associations between secondhand smoke and a few birth defects (namely, oral clefts and neural tube defects) have been noted in the scientific literature, to our knowledge, there is no single or comprehensive source of population-based information on its associations with a range of birth defects among nonsmoking mothers. OBJECTIVE: We utilized data from the National Birth Defects Prevention Study, a large population-based multisite case-control study, to examine associations between maternal reports of periconceptional exposure to secondhand smoke in the household or workplace/school and major birth defects...
July 18, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27424371/cesarean-rate-and-risk-factors-for-singleton-breech-presentation-in-china
#18
Hong Cui, Yi Chen, QiuLing Li, Jing Chen, CaiXia Liu, Weiyuan Zhang
OBJECTIVE: To determine the risk factors for breech birth, as well as the rates of cesarean section in singleton breech births in different Chinese provinces. STUDY DESIGN: This retrospective, cross-sectional study included 109,736 singleton preterm and term infants, with 4,535 presenting breech. The risk factors of singleton breech were calculated by using multiple logistic regression analysis based on a cohort design (4,535 breech, 103,484 cephalic presentation)...
May 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27382214/outcome-of-diabetic-pregnancies-in-a-tertiary-referral-centre-varanasi
#19
Uma Pandey, Neeraj Kumar Agrawal, Shilpa Agrawal, Shuchita Batra
AIM: The study was done to determine the maternal and fetal outcome of pregnancies complicated by maternal diabetes either Gestational Diabetes Mellitus (GDM) or preexisting (type 1 or type 2) diabetes over a period from March 2011 to Feb 2013 in a tertiary care hospital, Varanasi. METHODS: This is a retrospective audit of the maternal and fetal outcome of women who presented to the Sir Sundar Lal Hospital, Department of Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India from March 2011 to Feb 2013, with GDM or pre-existing type 1 or type 2 Diabetes with pregnancy...
August 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27337958/management-of-type-1-diabetes-in-pregnancy
#20
REVIEW
Anna Z Feldman, Florence M Brown
Women with type 1 diabetes (T1DM) have unique needs during the preconception, pregnancy, and postpartum periods. Preconception counseling is essential for women with T1DM to minimize pregnancy risks. The goals of preconception care should be tight glycemic control with a hemoglobin A1c (A1C) < 7 % and as close to 6 % as possible, without significant hypoglycemia. This will lower risks of congenital malformations, preeclampsia, and perinatal mortality. The safety of medications should be assessed prior to conception...
August 2016: Current Diabetes Reports
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