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L-Glutamine

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https://www.readbyqxmd.com/read/29348849/reduced-levels-of-n-methyl-2-pyridone-5-carboxamide-and-lysophosphatidylcholine-16-0-in-the-serum-of-patients-with-intrahepatic-cholangiocarcinoma-and-the-correlation-with-recurrence-free-survival
#1
Kyung-Hee Kim, Jungnam Joo, Boram Park, Sang-Jae Park, Woo Jin Lee, Sung-Sik Han, Tae Hyun Kim, Eun Kyung Hong, Sang Myung Woo, Byong Chul Yoo
We searched for metabolic biomarkers that may predict the prognosis of patients with intrahepatic cholangiocarcinoma (IHCC). To this end, a total of 237 serum samples were obtained from IHCC patients (n = 87) and healthy controls (n = 150), and serum metabolites were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Two stratified algorithms were used to select the metabolites, the levels of which predicted the prognosis of IHCC patients. We performed MS/MS and multiple-reaction-monitoring MS analyses to identify and quantify the selected metabolites...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29343523/a-novel-l-asparaginase-with-low-l-glutaminase-coactivity-is-highly-efficacious-against-both-t-and-b-cell-acute-lymphoblastic-leukemias-in-vivo
#2
Hien Anh Nguyen, Ying Su, Jenny Yu Zhang, Aleksandar Antanasijevic, Michael Caffrey, Amanda M Schalk, Li Liu, Damiano Rondelli, Annie Oh, Dolores L Mahmud, Maarten C Bosland, Andre Kajdacsy-Balla, Sofie Peirs, Tim Lammens, Veerle Mondelaers, Barbara De Moerloose, Steven Goossens, Michael J Schlicht, Kasim K Kabirov, Alexander V Lyubimov, Bradley J Merrill, Yogen Saunthararajah, Pieter Van Vlierberghe, Arnon Lavie
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug L-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine-dependency of ALL cells. In addition to hydrolyzing the amino acid L-asparagine, all FDA-approved L-asparaginases also have significant L-glutaminase coactivity. Since several reports suggest that L-glutamine depletion correlates with many of the side effects of these drugs, enzyme variants with reduced L-glutaminase coactivity might be clinically beneficial if their anti-leukemic activity would be preserved...
January 17, 2018: Cancer Research
https://www.readbyqxmd.com/read/29321939/isolation-of-rickettsia-amblyommatis-in-huvec-line
#3
S Santibáñez, A Portillo, A M Palomar, J A Oteo
Rickettsia amblyommatis, formerly named Rickettsia amblyommii and 'Candidatus Rickettsia amblyommii' is an intracellular bacterium belonging to the spotted fever group Rickettsia. It is highly prevalent in Amblyomma americanum and in other Amblyomma spp. throughout the Western Hemisphere. R. amblyommatis has been cultivated in chicken fibroblast, primary embryonated chicken eggs, Vero cells and arthropod-derived cells. Because of the affinity of rickettsiae to invade vascular endothelial cells, we tried to isolate R...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29301018/herbivore-derived-fatty-acid-amides-elicit-reactive-oxygen-species-burst-in-plants
#4
Anna Block, Shawn A Christensen, Charles T Hunter, Hans T Alborn
Reactive oxygen species (ROS) can be elicited by many forms of stress, including pathogen attack, abiotic stress, damage and insect infestation. Perception of microbe- or damage-associated elicitors triggers an ROS burst in many plant species; however, the impact of herbivore fatty-acid amides on ROS elicitation remains largely unexplored. In this study we show that the lepidopteran-derived fatty-acid amide elicitor N-linolenoyl-L-glutamine (GLN18:3) can induce a ROS burst in multiple plant species. Furthermore, in Arabidopsis this ROS burst is partially dependent on the plasma membrane localized NADPH oxidases RBOHD and RBOHF, and an Arabidopsis rbohD/F double mutant produces enhanced GLN18:3-induced jasmonic acid...
December 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29296801/pharmacotherapeutical-strategies-in-the-prevention-of-acute-vaso-occlusive-pain-in-sickle-cell-disease-a-systematic-review
#5
REVIEW
Joep W R Sins, David J Mager, Shyrin C A T Davis, Bart J Biemond, Karin Fijnvandraat
Sickle-cell disease (SCD) is characterized by frequent and painful vaso-occlusive crises (VOCs). Various treatments have been evaluated over the years. However, a clear overview is lacking. The objective of this study was to systematically review all pharmacotherapeutical strategies in the prevention of VOCs beyond hydroxyurea. We performed a systematic literature search (MEDLINE, Embase, CENTRAL). Eligible studies were controlled clinical trials evaluating pharmacotherapeutical interventions targeting the reduction of VOCs in patients with SCD...
August 22, 2017: Blood Advances
https://www.readbyqxmd.com/read/29227501/chondrogenic-potential-of-macroporous-biodegradable-cryogels-based-on-synthetic-poly-%C3%AE-amino-acids
#6
T Sedlačík, O K Acar, H Studenovská, I Kotelnikov, J Kučka, Z Konečná, T Zikmund, J Kaiser, G T Kose, F Rypáček
In this study, the potential of highly porous hydrogels based on biodegradable synthetic poly(α-amino acids) to support proliferation and chondrogenesis of human dental pulp stem cells (hDPSCs) was investigated. Covalently crosslinked gels with permanent pores were formed under cryogenic conditions by free-radical copolymerization of poly[N5-(2-hydroxyethyl)-l-glutamine-stat-N5-(2-methacryloyl-oxy-ethyl)-l-glutamine] (PHEG-MA) with 2-hydroxyethyl methacrylate (HEMA) and N-propargyl methacrylamide (PrMAAm) as minor co-monomers...
December 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/29206200/l-glutamine-attenuates-apoptosis-induced-by-endoplasmic-reticulum-stress-by-activating-the-ire1%C3%AE-xbp1-axis-in-ipec-j2-a-novel-mechanism-of-l-glutamine-in-promoting-intestinal-health
#7
Qian Jiang, Jiashun Chen, Shaojuan Liu, Gang Liu, Kang Yao, Yulong Yin
Intestinal absorption and barrier malfunctions are associated with endoplasmic reticulum stress (ERS) in the intestine. We induced ERS by exposing the intestinal porcine epithelial cell line J2 (IPEC-J2) to tunicamycin (TUNI) to explore the potential of l-glutamine to reduce ERS-induced apoptosis. Our experiments demonstrated that exposing cells to TUNI results in spontaneous ERS and encourages the upregulation of glucose-regulated protein 78 (GRP78). Prolonged TUNI-induced ERS was found to increase apoptosis mediated by C/enhancer binding protein homologous protein (CHOP), accompanied by GRP78 downregulation...
December 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29172854/design-of-composite-microparticle-systems-based-on-pectin-and-waste-material-of-propolis-for-modified-l-alanyl-l-glutamine-release-and-with-immunostimulant-activity
#8
Mônica Villa Nova, Bianca A Ratti, Leandro S Herculano, Paulo R S Bittencourt, Cláudio R Novello, Roberto Barbosa Bazotte, Sueli de Oliveira Silva Lautenschlager, Marcos Luciano Bruschi
Catabolic conditions like acquired immunodeficiency syndrome, cancer and burn can cause immunosuppression. Amino acids such as alanine and glutamine are essential for the activity of the immune system. Propolis is immunostimulant and the waste of propolis extraction has been reused with technological and therapeutic purposes. Therefore, this study describes the association of propolis byproduct extract with pectin to prepare spray-dried microparticles containing the dipeptide L-alanyl-L-glutamine as stimulant systems of neutrophils...
November 27, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29163437/transport-deficiency-is-the-molecular-basis-of-candida-albicans-resistance-to-antifungal-oligopeptides
#9
Marta Schielmann, Piotr Szweda, Katarzyna Gucwa, Marcin Kawczyński, Maria J Milewska, Dorota Martynow, Joachim Morschhäuser, Sławomir Milewski
Oligopeptides incorporating N(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05-50 μg mL(-1) range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing hexa-, hepta-, and undecapeptide (F6, F7, and F11) were taken up by the oligopeptide transporters (OPT) oligopeptide permeases, preferably by Opt2p/Opt3p...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29138359/comparative-effects-of-intraduodenal-amino-acid-infusions-on-food-intake-and-gut-hormone-release-in-healthy-males
#10
Robert E Steinert, Sina S Ullrich, Nori Geary, Lori Asarian, Marco Bueter, Michael Horowitz, Christine Feinle-Bisset
In contrast to the many studies of the effects of individual amino acids (AAs) on eating, no studies have compared the effects of different AAs on eating and underlying preabsorptive gastrointestinal mechanisms. To compare the effects of intraduodenal infusions of l-tryptophan (TRP), l-leucine (LEU), l-phenylalanine (PHE) and l-glutamine (GLN) on appetite, gastrointestinal hormone responses (including ghrelin, cholecystokinin (CCK), peptide YY (PYY) and glucagon-like peptide-1 [GLP-1]), glycemia (glucagon, insulin and glucose) and test meal size in healthy males, we retrospectively analyzed data from four published independent, randomized, double-blind, placebo-controlled studies of 90-min intraduodenal infusions of the individual AAs...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29119243/retraction-note-to-l-glutamine-supplementation-induces-insulin-resistance-in-adipose-tissue-and-improves-insulin-signalling-in-liver-and-muscle-of-rats-with-diet-induced-obesity
#11
P O Prada, S M Hirabara, C T de Souza, A A Schenka, H G Zecchin, J Vassallo, L A Velloso, E Carneiro, J B C Carvalheira, R Curi, M J Saad
In light of forensic evidence indicating duplication and/or manipulation of western blot images the Editor-in-Chief is retracting the article cited above.
November 8, 2017: Diabetologia
https://www.readbyqxmd.com/read/29090226/fifty-percent-ethanolic-extract-of-momordica-charantia-inhibits-adipogenesis-and-promotes-adipolysis-in-3t3-l1-pre-adipocyte-cells
#12
Chikkavadaragudi Ramachandra Shobha, Vishwanath Prashant, Prashant Akila, Rangaswamy Chandini, Maduvanahalli Nataraj Suma, Hattur Basavanagowdappa
BACKGROUND: Natural products have gained importance recently for the treatment of obesity and its complications, partly because of the side effects of modern drugs.Hence, we aimed to study and compare the effect of varying concentrations of Momordicacharantiaon adipogenesis and adipolysis using 3T3-L1 pre-adipocyte cell lines. METHODS: 3T3-L1 pre-adipocytes were procured from the National Center for Cell Sciences, Pune, and cultured in Dulbecco's Modified Eagle's Media (DMEM) supplemented with 20% fetal bovine serum (FBS) and 1 mM L-glutamine...
October 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29023101/biosynthesis-of-nucleoside-diphosphoramidates-in-campylobacter-jejuni
#13
Zane W Taylor, Haley A Brown, Hazel M Holden, Frank M Raushel
Campylobacter jejuni is a pathogenic Gram-negative bacterium and a leading cause of food-borne gastroenteritis. C. jejuni produces a capsular polysaccharide (CPS) that contains a unique O-methyl phosphoramidate modification (MeOPN). Recently, the first step in the biosynthetic pathway for the assembly of the MeOPN modification to the CPS was elucidated. It was shown that the enzyme Cj1418 catalyzes the phosphorylation of the amide nitrogen of l-glutamine to form l-glutamine phosphate. In this investigation, the metabolic fate of l-glutamine phosphate was determined...
October 24, 2017: Biochemistry
https://www.readbyqxmd.com/read/29018296/pharmaceutical-approval-update
#14
Michele B Kaufman
L-glutamine oral powder (Endari) for reducing the acute complications of sickle cell disease; edaravone (Radicava) for the treatment of amyotrophic lateral sclerosis; and midostaurin (Rydapt) for the treatment of acute myeloid leukemia in combination with chemotherapy.
October 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28987406/ametryn-removal-by-metarhizium-brunneum-biodegradation-pathway-proposal-and-metabolic-background-revealed
#15
Rafał Szewczyk, Anna Kuśmierska, Przemysław Bernat
Ametryn is a representative of a class of s-triazine herbicides absorbed by plant roots and leaves and characterized as a photosynthesis inhibitor. It is still in use in some countries in the farming of pineapples, soybean, corn, cotton, sugar cane or bananas; however, due to the adverse effects of s-triazine herbicides on living organisms use of these pesticides in the European Union has been banned. In the current study, we characterized the biodegradation of ametryn (100 mg L(-1)) by entomopathogenic fungal cosmopolite Metarhizium brunneum...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28980034/effect-of-the-route-of-nutrition-and-l-alanyl-l-glutamine-supplementation-in-amino-acids-concentration-in-trauma-patients
#16
J M Raurich, J A Llompart-Pou, A García-de-Lorenzo, A Buño Soto, P Marsé, G Frontera, J Pérez-Bárcena
PURPOSE: Our purpose was to assess the amino acids' (AAs) profile in trauma patients and to assess the effect of the route of nutrition and the exogenous ALA-GLN dipeptide supplementation on plasma AAs' concentration. METHODS: This is a secondary analysis of a previous randomized controlled trial. On day 1 and day 6 after trauma, plasma concentration of 25 AAs was measured using reverse phase high-performance liquid chromatography. Results were analyzed in relation to the route of nutrition and supplementation of ALA-GLN dipeptide...
October 4, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28971241/effects-of-l-theanine-on-anxiety-like-behavior-cerebrospinal-fluid-amino-acid-profile-and-hippocampal-activity-in-wistar-kyoto-rats
#17
Shintaro Ogawa, Miho Ota, Jun Ogura, Koichi Kato, Hiroshi Kunugi
RATIONALE AND OBJECTIVES: The amino acid L-theanine (N-ethyl-L-glutamine) has historically been considered a relaxing agent. In the present study, we examined the effects of repeated L-theanine administration on behavior, levels of amino acids in the cerebrospinal fluid (CSF), and hippocampal activity in Wistar Kyoto (WKY) rats, an animal model of anxiety and depressive disorders. METHODS: Behavioral tests were performed after 7-10 days of L-theanine (0.4 mg kg(-1) day(-1)) or saline administration, followed by CSF sampling for high-performance liquid chromatography (HPLC) analysis...
October 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28967640/endometrial-stromal-cells-isolation-expansion-morphological-and-functional-properties
#18
A V Zlatska, A E Rodnichenko, O S Gubar, D O Zubov, S N Novikova, R G Vasyliev
AIM: We aimed to study biological properties of human endometrial stromal cells in vitro. MATERIALS AND METHODS: The endometrium samples (n = 5) were obtained by biopsy at the first phase of the menstrual cycle from women with endometrial hypoplasia. In all cases, a voluntary written informed consent was obtained from the patients. Endometrial fragments were dissociated by enzymatic treatment. The cells were cultured in DMEM/F12 supplemented with 10% FBS, 2 mМ L-glutamine and 1 ng/ml FGF-2 in a multi-gas incubator at 5% CO2 and 5% O2...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28965405/metabolic-characterization-of-dairy-cows-treated-with-gossypol-by-blood-biochemistry-and-body-fluid-untargeted-metabolome-analyses
#19
Chaohua Tang, Kai Zhang, Tengfei Zhan, Qingyu Zhao, Junmin Zhang
To characterize the metabolic disorders of dairy cows treated with gossypol, 12 dairy cows were assigned to either a control group or a treatment group that was fed 1000 mg of gossypol per kilogram of dry matter feed for 28 days. Milk quality was adversely affected, as both milk protein and lactose levels were significantly decreased in the gossypol-treated group (3.40% vs 3.16%, P = 0.044; 5.15% vs 4.91%, P = 0.027; respectively). Plasma samples revealed increases in alanine aminotransferase (P = 0.092), choline esterase (P = 0...
October 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28960829/separation-and-determination-of-peptide-metabolite-of-bacillus-licheniformis-in-a-microbial-fuel-cell-by-high-speed-capillary-micellar-electrokinetic-chromatography
#20
Wei Wang, Ruiguang Bai, Xiaoyu Cai, Ping Lin, Lihong Ma
A method using high-speed capillary micellar electrokinetic chromatography and a microbial fuel cell was applied to determine the metabolite of the peptides released by Bacillus licheniformis. Two peptides, l-carnosine and l-alanyl-l-glutamine were used as the substrate to feed Bacillus licheniformis in a microbial fuel cell. The metabolism process of the bacterium was monitored by analyzing the voltage outputs of the microbial fuel cell. A home-made spontaneous injection device was applied to perform high-speed capillary micellar electrokinetic chromatography...
September 27, 2017: Journal of Separation Science
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