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https://www.readbyqxmd.com/read/28761349/excoriation-skin-picking-disorder-a-systematic-review-of-treatment-options
#1
REVIEW
Christine Lochner, Annerine Roos, Dan J Stein
Although pathological skin-picking has been documented in the medical literature since the 19th century, it has only recently been included as a distinct entity in psychiatric classification systems. In the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition and the proposed International Classification of Diseases, Eleventh Revision, excoriation (skin-picking) disorder (ED), also known as neurotic excoriation, psychogenic excoriation, or dermatillomania), is described as recurrent picking of skin, leading to skin lesions and significant distress or functional impairment...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28755270/embodied-conversational-agents-for-the-detection-and-prevention-of-suicidal-behaviour-current-applications-and-open-challenges
#2
Juan Martínez-Miranda
Embodied conversational agents (ECAs) are advanced computational interactive interfaces designed with the aim to engage users in the continuous and long-term use of a background application. The advantages and benefits of these agents have been exploited in several e-health systems. One of the medical domains where ECAs are recently applied is to support the detection of symptoms, prevention and treatment of mental health disorders. As ECAs based applications are increasingly used in clinical psychology, and due that one fatal consequence of mental health problems is the commitment of suicide, it is necessary to analyse how current ECAs in this clinical domain support the early detection and prevention of risk situations associated with suicidality...
September 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28754582/catatonia-in-children-and-adolescents-new-perspectives
#3
Xavier Benarous, Marie Raffin, Vladimir Ferrafiat, Angèle Consoli, David Cohen
INTRODUCTION: Catatonia is a rare and severe psychomotor condition in children and adolescents. In the current report, we aimed to review the recent literature. METHOD: Using a PRISMA approach, we searched MEDLINE between 1982 and 2017 using the keywords 'CATATONIA' and 'CHILD' or 'ADOLESCENT'. In total, we reviewed 130 reports (controlled study, N=4; clinical chart, N=23; case report, N=54; and editorial/review, N=42). RESULTS: Several aspects seem to be age specific: (1) although the clinical presentation resembles that in adults, some symptoms are important in children and adolescents (e...
July 25, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28733193/traditional-neurotherapeutics-approach-intended-for-direct-nose-to-brain-delivery
#4
REVIEW
Zohreh Abolhasanzadeh, Hajar Ashrafi, Parmis Badr, Amir Azadi
ETHNOPHARMACOLOGICAL RELEVANCE: Nasal delivery systems have a significant role in Persian traditional medicine. Most of them were utilized for central nervous system (CNS)-related disorders. In modern medicine, nasal drug delivery systems for brain delivery are highly regarded. AIM OF THE STUDY: Despite recent advances in drug delivery to the (CNS), delivery of therapeutics to the brain remains a major challenge because of the blood brain barrier (BBB). There are several mechanisms which regulate the drug transfer across the BBB...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28687709/the-effects-of-public-access-defibrillation-on-survival-after-out-of-hospital-cardiac-arrest-a-systematic-review-of-observational-studies
#5
Josefine Bækgaard, Søren Viereck, Thea Møller, Annette Ersbøll, Freddy Lippert, Fredrik Folke
Background -Despite recent advances, the average survival after out-of-hospital cardiac arrest (OHCA) remains below 10%. Early defibrillation by an automated external defibrillator (AED) is the most important intervention for OHCA patients, showing survival proportions above 50%. Accordingly, placement of AEDs in the community as part of a public access defibrillation program (PAD) is recommended by international guidelines. However, different strategies have been proposed on how exactly to increase and make use of public available AEDs...
July 7, 2017: Circulation
https://www.readbyqxmd.com/read/28675017/-analysis-of-the-current-status-of-research-on-human-papillomavirus-associated-head-and-neck-cancers-based-on-recent-chinese-literature
#6
REVIEW
Liu Yan, Cao Mingxin, Wu Jiashun, Gao Xiaolei, Liang Xinhua
OBJECTIVE: To analyze the current status of research on human papillomavirus (HPV)-associated head and neck cancers in China using national and international references. METHODS: We searched for bibliographies in the electronic databases of Sichuan University, including Chinese Biological and Medical Database (CBM), China Science and Technology Journal Database (VIP), and Wanfang Journal Database. Then, data was selected and extracted to analyze the basic characteristics of HPV-related head and neck cancers, the general prevalence of HPV, and the effects of various clinic pathological indicators on HPV patients...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28657444/bridging-the-gap-for-lipid-lowering-therapy-plaque-regression-coronary-computed-tomographic-angiography-and-imaging-guided-personalized-medicine
#7
Alan C Kwan, Konstantinos N Aronis, Veit Sandfort, Roger S Blumenthal, David A Bluemke
Lipid-lowering therapy effectively decreases cardiovascular risk on a population level, but it remains difficult to identify an individual patient's personal risk reduction while following guideline directed medical therapy, leading to overtreatment in some patients and cardiovascular events in others. Recent improvements in cardiac CT technology provide the ability to directly assess an individual's atherosclerotic disease burden, which has the potential to personalize risk assessment for lipid-lowering therapy...
July 6, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28632829/-advances-in-dengue-virus-research-in-colombia-the-role-of-cellular-micrornas-as-an-anti-dengue-virus-response
#8
Juan Camilo Castrillón-Betancur, Silvio Urcuqui-Inchima
Dengue is one of the most important mosquito-borne diseases, and its incidence has increased at an alarming rate in recent years, becoming a real public health problem. Currently, there is no vaccine or medication or proper treatment for dengue control. Considering this situation, it is necessary to prioritize the search for new alternatives and strategies for dengue prevention and control, in order to reduce not only the economic burden of endemic countries, but also to improve the quality of life of patients...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28609021/the-critical-role-of-ebus-tbna-cytology-in-the-staging-of-mediastinal-lymph-nodes-in-lung-cancer-patients-a-correlation-study-with-positron-emission-tomography-findings
#9
Mohammed T Lilo, Derek B Allison, Bouchra K Younes, Min Cui, Fred B Askin, Edward Gabrielson, Qing Kay Li
BACKGROUND: The sensitivity and specificity of positron emission tomography (PET) have been significantly improved for the identification of malignancies in recent years; however, it is still necessary to confirm PET findings in a lymph node (LN) by direct tissue sampling. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the most commonly used approach for diagnosing and staging mediastinal LNs, particularly in lung cancer patients with locally advanced disease...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28606838/the-role-of-low-intensity-pulsed-ultrasound-on-cartilage-healing-in-knee-osteoarthritis-a-review
#10
REVIEW
Joshua B Rothenberg, Prathap Jayaram, Usker Naqvi, Joslyn Gober, Gerard A Malanga
Ultrasound (US) is a therapeutic modality that has been used in the treatment of musculoskeletal conditions for decades. In recent years, there have been technological advancements using low-intensity pulsed ultrasound (LIPUS) as a clinical modality. The purpose of this review was to critically examine the medical literature to determine the effects of LIPUS on the chondrogenic properties of knee osteoarthritis. A literature search of 3 major databases (PubMed, Scopus, and EMBASE) was performed. Two independent physician reviewers screened titles and abstracts, yielding a total of 18 relevant articles after the inclusion and exclusion criteria were applied...
June 9, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28593466/high-content-drug-screening-for-rare-diseases
#11
REVIEW
F Bellomo, D L Medina, E De Leo, A Panarella, F Emma
Per definition, rare diseases affect only a small number of subjects within a given population. Taken together however, they represent a considerable medical burden, which remains poorly addressed in terms of treatment. Compared to other diseases, obstacles to the development of therapies for rare diseases include less extensive physiopathology knowledge, limited number of patients to test treatments, and poor commercial interest from the industry. Recently, advances in high-throughput and high-content screening (HTS and HCS) have been fostered by the development of specific routines that use robot- and computer-assisted technologies to automatize tasks, allowing screening of a large number of compounds in a short period of time, using experimental model of diseases...
June 7, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28580508/economics-of-early-warning-scores-for-identifying-clinical-deterioration-a-systematic-review
#12
A Murphy, J Cronin, R Whelan, F J Drummond, E Savage, J Hegarty
AIM: In 2013, a National Early Warning System (EWS) was implemented in Ireland. Whilst evidence exists to support the clinical effectiveness of EWS in the acute health care setting, there is a paucity of information on their cost and cost effectiveness. The objective of this systematic literature review was to critically evaluate the economic literature on the use of EWS in adult patients in acute health care settings for the timely detection of physiological deterioration. METHODS: A systematic literature review was conducted to accumulate the economic evidence on the use of EWS in adult patients in acute health care settings...
June 3, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28548893/dynamic-decision-making-learning-processes-and-new-research-directions
#13
Cleotilde Gonzalez, Pegah Fakhari, Jerome Busemeyer
OBJECTIVE: The aim of this manuscript is to provide a review of contemporary research and applications on dynamic decision making (DDM). BACKGROUND: Since early DDM studies, there has been little systematic progress in understanding decision making in complex, dynamic systems. Our review contributes to better understanding of decision making processes in dynamic tasks. METHOD: We discuss new research directions in DDM to highlight the value of simplification in the study of complex decision processes, divided into experimental and theoretical/computational approaches, and focus on problems involving control tasks and search-and-choice tasks...
August 2017: Human Factors
https://www.readbyqxmd.com/read/28521703/recent-advances-in-antiepileptic-herbal-medicine
#14
Stephen M Manchishi
Epilepsy is one of the most common neurological disorders worldwide, with about 80 percent of cases thought to be in developing nations where it is mostly linked to superstition. Most cases of epilepsy are idiopathic, though brain injury, brain tumor, severe systemic infection and genetic mutations have been implicated in some cases. Anti-epileptic drugs (AEDs) currently in existence are not sufficient to contain the disorder. This is not only because of their limited availability and cost, but also their adverse side effects...
May 18, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28501667/update-and-new-insights-in-encephalitis
#15
REVIEW
Alexandra Mailles, Jean-Paul Stahl, Karen C Bloch
BACKGROUND: Encephalitis is a medical condition possibly caused by an unlimited number of infectious agents. AIMS: Our review aims at giving an overview of the recent discoveries and advances in encephalitis presentation, diagnosis and management, including in the field of emerging diseases. SOURCES: We search the literature using Pubmed and Embase to identify the most relevant new data published over the last years in the field of infectious encephalitis...
May 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28475137/assessing-the-racial-and-ethnic-disparities-in-breast-cancer-mortality-in-the-united-states
#16
REVIEW
Clement G Yedjou, Paul B Tchounwou, Marinelle Payton, Lucio Miele, Duber D Fonseca, Leroy Lowe, Richard A Alo
Breast cancer is the second leading cause of cancer related deaths among women aged 40-55 in the United States and currently affects more than one in ten women worldwide. It is also one of the most diagnosed cancers in women both in wealthy and poor countries. Fortunately, the mortality rate from breast cancer has decreased in recent years due to increased emphasis on early detection and more effective treatments in White population. Although the mortality rates have declined in some ethnic populations, the overall cancer incidence among African American and Hispanic populations has continued to grow...
May 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28462943/media-reporting-of-protect-a-disconnect-in-information-dissemination
#17
M E Westerman, B Bhindi, R Choo, M T Gettman, R J Karnes, L Klotz, S A Boorjian
BACKGROUND: Given the central role of the media in disseminating information to the public, we analyzed news coverage of the recent publication from ProtecT to assess views on treatment, the level of detail presented and degree of bias. METHODS: We applied a predefined search strategy to identify all news articles reporting on ProtecT within 30 days of its publication. Articles were independently assessed by two urologists and two lay persons using five-point Likert scales...
May 2, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28428947/update-on-programmed-death-1-and-programmed-death-ligand-1-inhibition-in-the-treatment-of-advanced-or-metastatic-non-small-cell-lung-cancer
#18
REVIEW
Marco A J Iafolla, Rosalyn A Juergens
PURPOSE: Non-small-cell lung cancer (NSCLC) has a large worldwide prevalence with a high mortality rate. Chemotherapy has offered modest improvements in survival over the past two decades. Immune checkpoint modulation with programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibition has shown the promise of changing the future landscape of cancer therapy. This update reviews recent advances in the treatment of NSCLC with immune checkpoint modulation. METHODS: Publications and proceedings were identified from searching PubMed and proceedings from the annual meetings of the American Society of Clinical Oncology, European Society for Medical Oncology, and European Lung Cancer Conference...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28426103/neurotoxicity-from-immune-checkpoint-inhibition-in-the-treatment-of-melanoma-a-single-centre-experience-and-review-of-the-literature
#19
L Spain, G Walls, M Julve, K O'Meara, T Schmid, E Kalaitzaki, S Turajlic, M Gore, J Rees, J Larkin
Background: Treatment with immune checkpoint inhibitors (ICPi) has greatly improved survival for patients with advanced melanoma in recent years. Anti-CTLA-4 and anti-PD1 antibodies have been approved following large Phase III trials. Immune-related neurological toxicity of varying severity has been reported in the literature. The cumulative incidence of neurotoxicity among ipilimumab, nivolumab and pembrolizumab is reported as <1% in published clinical trials. We aimed to identify the incidence of neurotoxicity in our institution across anti-CTLA4 and anti-PD-1 antibodies, including the combination of ipilimumab with nivolumab...
February 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28421875/three-dimensional-printing-and-its-applications-in-otorhinolaryngology-head-and-neck-surgery
#20
Trevor D Crafts, Susan E Ellsperman, Todd J Wannemuehler, Travis D Bellicchi, Taha Z Shipchandler, Avinash V Mantravadi
Objective Three-dimensional (3D)-printing technology is being employed in a variety of medical and surgical specialties to improve patient care and advance resident physician training. As the costs of implementing 3D printing have declined, the use of this technology has expanded, especially within surgical specialties. This article explores the types of 3D printing available, highlights the benefits and drawbacks of each methodology, provides examples of how 3D printing has been applied within the field of otolaryngology-head and neck surgery, discusses future innovations, and explores the financial impact of these advances...
November 1, 2016: Otolaryngology—Head and Neck Surgery
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