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https://www.readbyqxmd.com/read/28743024/a-method-to-evaluate-the-quality-of-clinical-gene-panel-sequencing-data-for-single-nucleotide-variant-detection
#1
Chung Lee, Joon S Bae, Gyu H Ryu, Nayoung K D Kim, Donghyun Park, Jongsuk Chung, Sungkyu Kyung, Je-Gun Joung, Hyun-Tae Shin, Seung-Ho Shin, Younglan Kim, Byung S Kim, Hojun Lee, Kyoung-Mee Kim, Jung-Sun Kim, Woong-Yang Park, Dae-Soon Son
Customized gene-panel tests, based on next-generation sequencing, have demonstrated their usefulness in a plethora of clinical settings. As with other clinical diagnostic techniques, gene-panel sequencing for clinical purposes requires precise quality control (QC) measures to ensure its reliability. Only detected variants are currently recorded in clinical reports; however, identifying whether a nondetected variant is a true or false negative is regarded essential in a clinical setting and, thus, a comprehensive QC measure is in demand...
July 22, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28742946/the-association-between-obesity-and-academic-performance-in-youth-a-systematic-review
#2
REVIEW
C C A Santana, J O Hill, L B Azevedo, T Gunnarsdottir, W L Prado
Previous studies have found that obesity could influence academic performance. The aim of this study was to systematically review the scientific evidence on the association between obesity and academic performance in school children. A systematic review of English articles was undertaken by using databases PubMed/Medline, ERIC, LILACS, SciELO and Web of Science. Cross-sectional and longitudinal studies examining the association between obesity and academic performance in children and adolescents, published between January 1990 and December 2016, were included...
July 25, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28742853/leadership-and-management-training-as-a-catalyst-to-health-system-strengthening-in-low-income-settings-evidence-from-implementation-of-the-zambia-management-and-leadership-course-for-district-health-managers-in-zambia
#3
Wilbroad Mutale, Anne-Thora Vardoy-Mutale, Arthur Kachemba, Roman Mukendi, Kupela Clarke, Dennis Mulenga
BACKGROUND: Research has shown that the modes of leadership and management may influence health outcomes. However, majority of health leaders and managers in many low-income countries are promoted on account of clinical expertise. It has been recognised that these new managers are often ill-prepared for managing complex health systems. In response to this challenge, the Zambian Ministry of Health (MoH) has developed the Governance and Management Capacity Building (GMCB) Strategic Plan (2012-2016), whose overarching goal is to improve health sector governance and create an environment that is result-oriented, accountable and transparent...
2017: PloS One
https://www.readbyqxmd.com/read/28741747/defending-the-scientific-integrity-of-conservation-policy-processes
#4
Carlos Carroll, Brett Hartl, Gretchen T Goldman, Daniel J Rohlf, Adrian Treves, Jeremy T Kerr, Euan G Ritchie, Richard T Kingsford, Katherine E Gibbs, Martine Maron, James E M Watson
Government agencies faced with politically controversial decisions often discount or ignore scientific information, whether from agency staff or nongovernmental scientists. Recent developments in scientific integrity (the ability to perform, use, communicate, and publish science free from censorship or political interference) in Canada, Australia, and the United States demonstrate a similar trajectory. A perceived increase in scientific-integrity abuses provokes concerted pressure by the scientific community, leading to efforts to improve scientific-integrity protections under a new administration...
July 25, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28741682/strengthening-the-laboratory-diagnosis-of-infections-caused-by-pathogenic-corynebacterium-species-in-the-vaccine-era
#5
REVIEW
Suresh Kumar Rajamani Sekar, Balaji Veeraraghavan, Shalini Anandan, Naveen Kumar Devanga Ragupathi, Lucky Sangal, Sudhir Joshi
Over the last three decades, successful implementation of the diphtheria vaccination in the developed and developing countries has reduced the infections caused by the toxigenic strains of C. diphtheriae, but a concomitant increase in the invasive infections due to the non-toxigenic strains was seen. In addition, the recent reports on the emergence of non-toxigenic toxin gene bearing strains (NTTB), having the potential to revert back to toxigenic form poses a significant threat to human beings. Besides infections caused by C...
July 25, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28741202/a-user-centred-approach-to-developing-bwell-a-mobile-app-for-arm-and-shoulder-exercises-after-breast-cancer-treatment
#6
Helena Harder, Patrick Holroyd, Lynn Burkinshaw, Phil Watten, Charles Zammit, Peter R Harris, Anna Good, Val Jenkins
PURPOSE: The study aim was to develop a mobile application (app) supported by user preferences to optimise self-management of arm and shoulder exercises for upper-limb dysfunction (ULD) after breast cancer treatment. METHODS: Focus groups with breast cancer patients were held to identify user needs and requirements. Behaviour change techniques were explored by researchers and discussed during the focus groups. Concepts for content were identified by thematic analysis...
July 24, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28741201/cost-effectiveness-of-a-locally-organized-surgical-outreach-mission-making-a-case-for-strengthening-local-non-governmental-organizations
#7
Adam Gyedu, Cameron Gaskill, Godfred Boakye, Francis Abantanga
INTRODUCTION: Many low- and middle-income countries (LMICs) have a high prevalence of unmet surgical need. Provision of operations through surgical outreach missions, mostly led by foreign organizations, offers a way to address the problem. We sought to assess the cost-effectiveness of surgical outreach missions provided by a wholly local organization in Ghana to highlight the role local groups might play in reducing the unmet surgical need of their communities. METHODS: We calculated the disability-adjusted life years (DALY) averted by surgical outreach mission activities of ApriDec Medical Outreach Group (AMOG), a Ghanaian non-governmental organization...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28740374/characterization-of-throat-microbial-flora-in-smokers-with-or-without-copd
#8
Wenqi Diao, Ning Shen, Yipeng Du, Ke Qian, Bei He
The study aimed to determine the relationship between throat microbiome and COPD. Sixty-five Chinese males (n=20, smokers without COPD; n=45 smokers with COPD) were included. Nonmetric multidimensional scaling indicated differences of microbiome between COPD and controls, but no difference was observed between COPD patients with differing degrees of lung function or disease severity. Rarefaction analyses suggested that operational taxonomic units (OTUs, species-level) richness decreased in COPD. The dominant taxa between COPD and controls were similar, but the proportions of taxonomic distribution were different...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28739799/lgr5-receptor-promotes-cell-cell-adhesion-in-stem-cells-and-colon-cancer-cells-via-the-iqgap1-rac1-pathway
#9
Kendra S Carmon, Xing Gong, Jing Yi, Ling Wu, Anthony Thomas, Catherine M Moore, Ikuo Masuho, David J Timson, Kirill A Martemyanov, Qingyun J Liu
Leucine rich repeat containing G protein coupled receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most notably in the intestinal crypts and is highly upregulated in many colorectal, hepatocellular, and ovarian cancers. LGR5 activation by R-spondin (RSPO) ligands potentiates Wnt/β-catenin signaling in vitro, yet deletion of LGR5 in stem cells has little or no effect on Wnt/β-catenin signaling or cell proliferation in vivo. Remarkably, modulation of LGR5 expression has a major impact on the actin cytoskeletal structure and cell adhesion in the absence of RSPO stimulation, but the molecular mechanism is unclear...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28739648/hepatocyte-nuclear-factor-1%C3%AE-controls-mitochondrial-respiration-in-renal-tubular-cells
#10
Audrey Casemayou, Audren Fournel, Alessia Bagattin, Joost Schanstra, Julie Belliere, Stéphane Decramer, Dimitri Marsal, Marion Gillet, Nicolas Chassaing, Antoine Huart, Marco Pontoglio, Claude Knauf, Jean-Loup Bascands, Dominique Chauveau, Stanislas Faguer
AKI is a frequent condition that involves renal microcirculation impairment, infiltration of inflammatory cells with local production of proinflammatory cytokines, and subsequent epithelial disorders and mitochondrial dysfunction. Peroxisome proliferator-activated receptor γ coactivator 1-α (PPARGC1A), a coactivator of the transcription factor PPAR-γ that controls mitochondrial biogenesis and function, has a pivotal role in the early dysfunction of the proximal tubule and the subsequent renal repair. Here, we evaluated the potential role of hepatocyte nuclear factor-1β (HNF-1β) in regulating PPARGC1A expression in AKI...
July 24, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28739218/phase-behavior-of-a-fc-fusion-protein-reveals-generic-patterns-of-ion-specific-perturbation-on-protein-protein-interactions
#11
Le Zhang, Lei Yu, Jian Zhang-Van Enk, Gang Huang, Jifeng Zhang
Modulation of liquid-liquid phase separation temperature (Tph) for liquid-liquid phase separation (LLPS) of a Fc-fusion protein was studied at pH values below, near and above its pI where the net charge of the protein was positive, neutral and negative, respectively, in KF, KCl, KSCN and MgCl2 solutions. At the pH value near the pI, the monotonic drop in Tph for all the salt solutions suggests that both the anion and cation can disrupt attractive protein-protein interactions, effectively salting-in the protein...
July 21, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28738870/cross-sectional-description-of-nursing-and-midwifery-pre-service-education-accreditation-in-east-central-and-southern-africa-in-2013
#12
Carey F McCarthy, Jessica M Gross, Andre R Verani, Annette M Nkowane, Erica L Wheeler, Thokozire J Lipato, Maureen A Kelley
BACKGROUND: In 2013, the World Health Organization issued guidelines, Transforming and Scaling Up Health Professional Education and Training, to improve the quality and relevance of health professional pre-service education. Central to these guidelines was establishing and strengthening education accreditation systems. To establish what current accreditation systems were for nursing and midwifery education and highlight areas for strengthening these systems, a study was undertaken to document the pre-service accreditation policies, approaches, and practices in 16 African countries relative to the 2013 WHO guidelines...
July 24, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28738816/disease-activity-resilience-and-health-related-quality-of-life-in-chinese-patients-with-rheumatoid-arthritis-a-multi-center-cross-sectional-study
#13
Li Liu, Xin Xu, Neili Xu, Lie Wang
BACKGROUND: Positive psychological constructs that can moderate or mediate the negative impact of disease activity on health-related quality of life (HRQOL) in patients with rheumatoid arthritis (RA) have not been explored widely. This study aimed to assess the associations of disease activity, resilience with HRQOL and the moderating and mediating roles of resilience among Chinese RA patients. METHODS: A multi-center, cross-sectional study was conducted in RA inpatients in northeast of China...
July 24, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28738522/combination-of-nrp1-mediated-irgd-with-5-fluorouracil-suppresses-proliferation-migration-and-invasion-of-gastric-cancer-cells
#14
Li Zhang, Yanfeng Xing, Qi Gao, Xuejun Sun, Di Zhang, Gang Cao
Gastric cancer is one of the most of common cancers in the world. 5-Fluorouracil (5-FU) has been identified as one of the standard first-line chemotherapy drugs for locally advanced or metastatic gastric cancer. However, poor tumor penetration, bad selectivity and toxic side effects are the major limitations for the application of chemotherapy drugs in anticancer therapy. Recently, plenty of studies demonstrate that the novel tumor-homing peptide iRGD could promote the tumor-penetrating capability of chemotherapy drugs in multiple cancers, and neuropilin-1 (NRP1) protein is the critical mediator for iRGD...
July 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738476/-relationship-between-risk-factors-of-liver-cancer-and-onset-age-in-ningxia-hui-autonomous-region
#15
Q Liu, B Liu, G R Ding
Objective: To investigate the clinical data of patients with hepatocellular carcinoma in Ningxia Hui Autonomous Region through questionnaire survey, explore the association between the risk factors of liver cancer and the onset age of disease in this area and provide evidence for prevention and treatment of liver diseases. Methods: A retrospectively analysis was conducted in 250 patients with primary hepatocellular carcinoma by using their clinical data collected through questionnaire survey to understand the relationship between gender, smoking, alcohol use, hypertension, diabetes mellitus, hyperlipidemia, family history of liver cancer, liver cirrhosis, HBV infection, eating fish history and other factors and the incidence of hepatocellular carcinoma by univariate and logistic multivariate regression models...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738370/drug-level-monitoring-on-admission-for-presurgical-epilepsy-evaluation
#16
Irina Constantinescu, Christian M Korff, Serge Vulliemoz, Fabienne Picard, Margitta Seeck
OBJECTIVE: Evaluation for surgical treatment is offered to patients who do not respond to antiepileptic drugs. Pseudo-pharmacoresistance (PPR) has been described in the context of impaired compliance, incorrect diagnosis of epilepsy or pharmacological interference resulting in too low blood levels. We were interested to determine the frequency and causes of PPR in patients admitted for presurgical evaluation. METHODS: We reviewed 553 drug levels in 199 patients and analyzed the relative frequency of drugs below reference range (10 and 20% below the range)...
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28738185/mother-and-child-characteristics-at-birth-and-early-age-leukemia-a-case-cohort-population-based-study-in-brazil
#17
Rejane de Souza Reis, Neimar de Paula Silva, Marceli de Oliveira Santos, Julio Fernando Pinto Oliveira, Luiz Claudio Santos Thuler, Beatriz de Camargo, Maria S Pombo-de-Oliveira
OBJECTIVE: The population-based cancer registries (PBCR) and the Information System on Live Births in Brazil (Sistema de Informações sobre Nascidos Vivos [SINASC]) have information that enables the test for risk factors associated with leukemia at an early age. The aim of this study was to identify maternal and birth characteristics associated with early-age acute leukemia (EAL) in Brazil. METHODS: A case-cohort study was performed using secondary dataset information of PBCR and SINASC...
July 21, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28738032/nurse-administered-hand-massage-integration-into-an-infusion-suite-s-standard-of-care%C3%A2
#18
Caitlin M Braithwaite, Deborah Ringdahl
BACKGROUND: Nurse-delivered hand massage is a safe and effective intervention that has potential for positively affecting nursing and patient outcomes.
. OBJECTIVES: Nurses in a National Cancer Institute-designated academic health center outpatient chemotherapy infusion suite were taught how to administer a hand massage to strengthen the nurse-patient relationship and improve patient experience, comfort, satisfaction, stress, and anxiety.
. METHODS: A pre-/postimplementation group comparison design was used...
August 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28738002/effects-of-storage-conditions-on-results-for-quantitative-and-qualitative-evaluation-of-proteins-in-canine-urine
#19
Marie-Laure Théron, Laetitia Piane, Laetitia Lucarelli, Rémi Henrion, Catherine Layssol-Lamour, Florence Palanché, Didier Concordet, Jean-Pierre D Braun, Catherine Trumel, Rachel Lavoué
OBJECTIVE To investigate effects of storage conditions on the canine urine protein-to-creatinine ratio (UPC) and on SDS-agarose gel electrophoresis (AGE) of urinary proteins. SAMPLE Urine specimens from 20 proteinuric (UPC > 0.5) and 20 nonproteinuric (UPC ≤ 0.2) dogs. PROCEDURES UPC and SDS-AGE were performed on urine specimens stored at room temperature (20°C) and 4°C for up to 5 days and at -20° and -80°C for up to 360 days; some specimens were subjected to 3 freeze-thaw cycles. Results were compared with those obtained for fresh urine specimens...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28737729/geographic-distribution-and-temporal-trends-of-hiv-1-subtypes-through-heterosexual-transmission-in-china-a-systematic-review-and-meta-analysis
#20
REVIEW
Peipei Xiao, Jianjun Li, Gengfeng Fu, Ying Zhou, Xiping Huan, Haitao Yang
Background: Heterosexual transmission (HST) has become the current predominant transmission pathways of the HIV-1 epidemic in China. The aim of this study was to explore the geographic and dynamic change of HIV-1 subtypes through HST in China from published studies. Methods: Several electronic databases were searched to identify the studies, and the overall prevalence of HIV-1 subtypes was estimated by a meta-analysis method. Subgroup analysis was conducted by study region and time period. Publication bias was evaluated using Egger's test...
July 24, 2017: International Journal of Environmental Research and Public Health
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