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https://www.readbyqxmd.com/read/28649271/effect-of-electrochemotherapy-on-human-herpesvirus-8-kinetics-in-classic-kaposi-sarcoma
#1
Noemy Starita, Gianluca Di Monta, Andrea Cerasuolo, Ugo Marone, Anna Maria Anniciello, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Electrochemotherapy (ECT) has shown to be an effective treatment for cutaneous and subcutaneous Kaposi sarcoma (KS) lesions. However, no study has investigated the impact of ECT treatment on the kinetics of human herpesvirus type 8 (HHV8), which is considered the necessary causal agent of KS. We aimed to evaluate HHV8 viral load and expression levels in patients affected by classic KS who received one or more ECT treatments and have been followed semi annually for up to four years...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28639696/modulation-of-global-sumoylation-by-kaposi-s-sarcoma-associated-herpesvirus-and-its-effects-on-viral-gene-expression
#2
Jinzhong Wang, Yuying Guo, Xu Wang, Rui Zhao, Ying Wang
Some viruses have evolved to exploit the host SUMOylation system to regulate their own replication. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes K-bZIP, a SUMO E3 ligase catalyzing the SUMOylation of viral and host proteins. KSHV also encodes replication and transcriptional activator (RTA), a SUMO-targeted ubiquitin ligase catalyzing the ubiquitination of SUMOylated proteins and targeting them for degradation. Using chronic KSHV-infected TRE × BCBL-1 RTA cells, the expression kinetics of K-bZIP and RTA, and the global SUMOylation level were detected...
June 22, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28623553/-kaposi-s-disease-in-an-hiv-positive-child-with-probable-contamination-from-his-grandmother
#3
A Dicko, Y Fofana, A Traoré, S Berthé, S Touré, C Lamissa, B Guindo, A Keita, O Faye
Kaposi's disease in children with HIV is rarely reported in everyday practice. This is a case study of cutaneous Kaposi's disease revealing HIV in a 5-year-old child with polymorphic eruption of papules and nodules on the face, trunk, back, and limbs. Histopathological examination confirmed the diagnosis of Kaposi's disease. The child's HIV serology was positive with a CD4 count of 240/mm3, normochromic and normocytic anemia, and a hemoglobin level at 8.5 g/dl. It was found that the child, after early weaning from his HIV-negative mother, had repeatedly suckled his healthy grandmother, who had no skin lesions but was HIV1 positive...
June 16, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28615210/a-conserved-leucine-zipper-motif-in-gammaherpesvirus-orf52-is-critical-for-distinct-microtubule-rearrangements
#4
Matthew S Loftus, Nancy Verville, Dean H Kedes
Productive viral infection often depends on manipulation of the cytoskeleton. Herpesviruses, including Rhesus monkey rhadinovirus (RRV) and its close homolog the oncogenic human gammaherpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), exploit microtubule-based retrograde transport to deliver their genomes to the nucleus. Subsequently, during the lytic phase of the life cycle, the maturing viral particles undergo orchestrated translocation to specialized regions within the cytoplasm, leading to tegumentation, secondary envelopment, and then egress...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28615201/the-latency-associated-nuclear-antigen-of-kaposi-s-sarcoma-associated-herpesvirus-inhibits-expression-of-sumo-sentrin-specific-peptidase-6-to-facilitate-latency-establishment
#5
Xiaoxi Lin, Rui Sun, Fang Zhang, Yuan Gao, Lianghua Bin, Ke Lan
Kaposi's sarcoma-associated herpesvirus (KSHV), belonging to γ-herpesviridae, typically displays two different phases in its lifecycle, the latent phase and the lytic phase. Latent-associated nuclear antigen (LANA), the primary viral product during latency, has been reported to bind to a series of cellular gene promoters to modulate gene transcription. To systemically elucidate the cellular genes regulated by LANA, we identified genome-wide LANA binding sites by chromatin immunoprecipitation coupled with sequencing (ChIP-seq)...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28611469/antimicrobial-sulfonamides-clear-latent-kaposi-sarcoma-herpesvirus-infection-and-impair-mdm2-p53-complex-formation
#6
Fabrizio Angius, Enrica Piras, Sabrina Uda, Clelia Madeddu, Roberto Serpe, Rachele Bigi, Wuguo Chen, Dirk P Dittmer, Raffaello Pompei, Angela Ingianni
Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8, is the causative agent of Kaposi sarcoma; this malignant angiosarcoma is usually treated with conventional antitumor agents that can control disease evolution, but do not clear the latent KSHV episome that binds to cellular DNA. Some commercial antibacterial sulfonamides were tested for the ability to suppress latent KSHV. Quantitative PCR (qPCR) and cytofluorometry assays were used for detecting both viral DNA and the latency factor LANA (latency-associated nuclear antigen) in BC3 cells, respectively...
June 14, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28609402/hiv-associated-kaposi-sarcoma-and-related-diseases
#7
Priscila H Gonçalves, Thomas S Uldrick, Robert Yarchoan
The search for the etiologic agent for Kaposi sarcoma (KS) led to the discovery of Kaposi sarcoma associated herpesvirus (KSHV) in 1994. KSHV, also called human herpesvirus-8 (HHV-8) has since been shown to be the etiologic agent for several other tumors and diseases, including primary effusion lymphoma (PEL), an extracavitary variant of PEL, KSHV-associated diffuse large B-cell lymphoma, a form of multicentric Castleman disease (MCD), and KSHV inflammatory cytokine syndrome (KICS). KSHV encodes several genes that interfere with innate and specific immunity, thwart apoptosis, enhance cell proliferation and cytokine production, and promote angiogenesis, and these play important roles in the disease pathogenesis...
June 12, 2017: AIDS
https://www.readbyqxmd.com/read/28606034/high-seroprevalence-of-human-herpesvirus-8-infection-in-hiv-positive-homosexual-men-in-jiangsu-province-china
#8
Jiayan Li, Jinyun Song, Guolei Tan, Jianfang Wang, Zhenxian Zhou, Xuping Wu
BACKGROUD: HIV-infected homosexual men are more frequently diagnosed with Kaposi's sarcoma. With the increase of HIV-infected homosexual men in China, we urgently need to know the KS-related human herpesvirus (KSHV/HHV-8) seroprevalence in this population. To investigate the HHV-8 prevalence among HIV-positive homosexual men, we recruited 183 patients naive of antiretroviral therapy (ART) whose blood samples present HIV-antibody positive confirmed by western blot. METHODS: HIV viral load was tested using Cobas TaqMan HIV-1 test Version 2...
June 12, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28602767/an-easily-transfectable-cell-line-that-produces-an-infectious-reporter-virus-for-routine-and-robust-quantitation-of-kaposi-s-sarcoma-associated-herpesvirus-reactivation
#9
Jennifer L DeCotiis, Noelle C Ortiz, Brian A Vega, David M Lukac
Reactivation of Kaposi's sarcoma-associated herpesvirus (KHSV; also known as Human herpesvirus (HHV)-8) from latency is associated with progression to disease. The primary experimental models for studying KSHV reactivation are B lymphocyte cell lines derived from patients with primary effusion lymphoma (PEL). PEL models have remained essential tools for understanding molecular details of latency and reactivation, yet they have shortcomings. In particular, PEL cells are difficult to transfect with plasmid DNA, which limits their routine use in studies that require introduction of exogenous DNA...
June 8, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28600495/functional-dissection-of-human-targets-for-kshv-encoded-mirnas-using-network-analysis
#10
Yu Wang, Yun Lin, Yanzhi Guo, Xuemei Pu, Menglong Li
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease, etc. In this study, we firstly systematically constructed the KSHV-encoded miRNA-regulated co-expressed protein-protein interaction network (CePPIN), which display the biological knowledge regarding the mechanism of miRNA-regulated KSHV pathogenesis. Then, we investigated the topological parameters for the proteins in CePPIN, especially for those miRNA targets and we found that cellular target genes of KSHV-encoded miRNAs tend to be hubs and bottlenecks in the network...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28592530/kaposi-s-sarcoma-associated-herpesvirus-utilizes-and-manipulates-rna-n-6-adenosine-methylation-to-promote-lytic-replication
#11
Fengchun Ye, E Ricky Chen, Timothy W Nilsen
N(6)-adenosine methylation (m(6)A) is the most common post-transcriptional RNA modification in mammalian cells. We found that most transcripts encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) undergo m(6)A modification. The levels of m(6)A-modified mRNAs increase substantially upon stimulation for lytic replication. Blocking m(6)A inhibits splicing of the pre-mRNA encoding replication transcription activator (RTA), a key KSHV lytic switch protein, and halts viral lytic replication. We identified several m(6)A sites in RTA pre-mRNA crucial for splicing through interactions with YTH domain containing 1 (YTHDC1), an m(6)A nuclear reader protein, in conjunction with serine/arginine-rich splicing factor 3 (SRSF3) and SRSF10...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28592529/guanylate-binding-protein-1-inhibits-nuclear-delivery-of-kaposi-s-sarcoma-associated-herpesvirus-virions-by-disrupting-formation-of-actin-filament
#12
Zhe Zou, Zhihua Meng, Chao Ma, Deguang Liang, Rui Sun, Ke Lan
Kaposi's sarcoma-associated herpesvirus (KSHV) is a typical gamma-herpesvirus which establishes persistent lifelong infection in host cells. In order to establish a successful infection, KSHV has evolved numerous immune-evasion strategies to bypass or hijack the host immune system. However, host cells still produce immune cytokines abundantly during KSHV primary infection. Whether the immune effectors produced are able to inhibit viral infection and how KSHV successfully conquers these immune effectors remain largely unknown...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28591700/restoration-of-immune-surface-molecules-in-kaposi-sarcoma-associated-herpesvirus-infected-cells-by-lenalidomide-and-pomalidomide
#13
David A Davis, Suraj Mishra, Holda A Anagho, Ashley I Aisabor, Prabha Shrestha, Victoria Wang, Yuki Takamatsu, Kenji Maeda, Hiroaki Mitsuya, Jerome B Zeldis, Robert Yarchoan
Kaposi sarcoma-associated herpesvirus (KSHV) is the cause of several tumors, including Kaposi sarcoma and primary effusion lymphoma (PEL). Most viruses have evolved means of escaping immune recognition. KSHV downregulates MHC-I expression during lytic infection, and expression of ICAM-1 and B7-2 (CD86) during latent infection, allowing evasion of T cell and natural killer immunity respectively. These effects are largely mediated by two KSHV-encoded proteins, K3 and K5. We show here that lenalidomide (Len) and pomalidomide (Pom) prevent down-regulation of MHC-I during lytic activation, and restore ICAM-1 and B7-2 surface expression in latently infected PEL cells...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28580733/case-report-of-a-primary-effusion-lymphoma-successfully-treated-with-oral-valganciclovir-after-failing-chemotherapy
#14
Juan Marquet, Kyra Velazquez-Kennedy, Sandra López, Amparo Benito, María-Jesús Blanchard, Jose Antonio Garcia-Vela
Primary effusion lymphoma is a rare non-Hodgkin lymphoma that presents with pleural effusions and lacking of tumour mass. It is universally associated with human herpesvirus 8 (HHV8) and is more frequent among immunosuppressed patients. There is no standard treatment, chemotherapy and anti-HIV therapy have been used with poor results, but there is still no strong evidence supporting the use of valganciclovir. We present the case of a HIV positive man that presented with pleural effusion compatible with primary effusion lymphoma and positivity for HHV8 DNA in blood...
June 4, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28572838/seroprevalence-of-antibodies-against-kaposi-s-sarcoma-associated-herpesvirus-among-hiv-negative-people-in-china
#15
Tiejun Zhang, Zhenqiu Liu, Jun Wang, Veenu Minhas, Charles Wood, Gary M Clifford, Na He, Silvia Franceschi
BACKGROUND: Little information on the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. METHODS: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28542909/the-role-of-metabolic-reprogramming-in-%C3%AE-herpesvirus-associated-oncogenesis
#16
REVIEW
Angela Kwok-Fung Lo, Christopher W Dawson, Lawrence S Young, Kwok-Wai Lo
The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways...
May 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28534512/a-viral-microrna-downregulates-metastasis-suppressor-cd82-and-induces-cell-invasion-and-angiogenesis-by-activating-the-c-met-signaling
#17
W Li, M Hu, C Wang, H Lu, F Chen, J Xu, Y Shang, F Wang, J Qin, Q Yan, B J Krueger, R Renne, S-J Gao, C Lu
Kaposi's sarcoma (KS) as the most common AIDS-associated malignancy is etiologically caused by KS-associated herpesvirus (KSHV). KS is a highly disseminated and vascularized tumor. KSHV encodes 12 pre-microRNAs that yield 25 mature microRNAs (miRNAs), but their roles in KSHV-induced tumor metastasis and angiogenesis remain largely unclear. KSHV-encoded miR-K12-6 (miR-K6) can generate two mature miRNAs, miR-K6-5p and miR-K6-3p. Recently, we have shown that miR-K6-3p induced cell migration and angiogenesis via directly targeting SH3 domain binding glutamate-rich protein (SH3BGR)...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28515293/virus-like-vesicles-of-kaposi-s-sarcoma-associated-herpesvirus-activate-lytic-replication-through-triggering-differentiation-signaling
#18
Danyang Gong, Xinghong Dai, Yuchen Xiao, Yushen Du, Travis J Chapa, Jeffrey R Johnson, Xinmin Li, Nevan J Krogan, Hongyu Deng, Ting-Ting Wu, Ren Sun
Virus-like vesicles (VLVs) are membrane enclosed vesicles that resemble native enveloped viruses in organization, but lack viral capsid and genome. During the productive infection of tumor associated gamma-herpesviruses, both virions and VLVs are produced and released into the extracellular space. However, studies of gamma-herpesvirus associated VLVs have been largely restricted by the technical difficulty of separating VLVs from mature virions. Here, we report a strategy of using a Kaposi's sarcoma-associated herpesvirus (KSHV) mutant defective in small capsid protein, unable to produce mature virions, to selectively isolate VLVs...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28506687/human-immunodeficiency-virus-hiv-and-epstein-barr-virus-ebv-related-lymphomas-pathology-view-point
#19
REVIEW
Ebru Linke-Serinsöz, Falko Fend, Leticia Quintanilla-Martinez
The contribution of Epstein Barr virus (EBV) and Kaposi sarcoma herpes virus (KSHV) to the development of specific types of malignant lymphomas occurring in the human immunodeficiency virus (HIV) setting has been extensively studied since the beginning of the HIV epidemic 35 years ago. The introduction of highly active antiretroviral therapies (HAART) in 1996 has changed dramatically the incidence of HIV-related malignancies. Nevertheless, malignant lymphomas continue to be the major group of malignances observed in HIV infected individuals, and the most common cause of cancer related-deaths...
July 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28502522/human-herpesvirus-8-related-diseases-histopathologic-diagnosis-and-disease-mechanisms
#20
REVIEW
Matthew Auten, Annette S Kim, Kyle T Bradley, Flavia G Rosado
The emergence of HIV/AIDS more than three decades ago led to an increased incidence of diseases caused by HHV8 co-infection, particularly Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Over time, the development of highly effective AIDS therapies has resulted in a decreased incidence of HHV8-associated entities, which are now more commonly found in patients with undiagnosed and/or untreated AIDS. Due to their rarity, some of these diseases may be difficult to recognize without appropriate clinical information...
July 2017: Seminars in Diagnostic Pathology
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