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KSHV (OR) HHV8

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https://www.readbyqxmd.com/read/28615210/a-conserved-leucine-zipper-motif-in-gammaherpesvirus-orf52-is-critical-for-distinct-microtubule-rearrangements
#1
Matthew S Loftus, Nancy Verville, Dean H Kedes
Productive viral infection often depends on manipulation of the cytoskeleton. Herpesviruses, including Rhesus monkey rhadinovirus (RRV) and its close homolog the oncogenic human gammaherpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8), exploit microtubule-based retrograde transport to deliver their genomes to the nucleus. Subsequently, during the lytic phase of the life cycle, the maturing viral particles undergo orchestrated translocation to specialized regions within the cytoplasm, leading to tegumentation, secondary envelopment, and then egress...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28465156/plasma-viral-mirnas-indicate-a-high-prevalence-of-occult-viral-infections
#2
Enrique Fuentes-Mattei, Dana Elena Giza, Masayoshi Shimizu, Cristina Ivan, John T Manning, Stefan Tudor, Maria Ciccone, Osman Aykan Kargin, Xinna Zhang, Pilar Mur, Nayra Soares do Amaral, Meng Chen, Jeffrey J Tarrand, Florea Lupu, Alessandra Ferrajoli, Michael J Keating, Catalin Vasilescu, Sai-Ching Jim Yeung, George A Calin
Prevalence of Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) varies greatly in different populations. We hypothesized that the actual prevalence of KSHV/HHV8 infection in humans is underestimated by the currently available serological tests. We analyzed four independent patient cohorts with post-surgical or post-chemotherapy sepsis, chronic lymphocytic leukemia and post-surgical patients with abdominal surgical interventions. Levels of specific KSHV-encoded miRNAs were measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and KSHV/HHV-8 IgG were measured by immunoassay...
June 2017: EBioMedicine
https://www.readbyqxmd.com/read/28455950/rhadinoviral-interferon-regulatory-factor-homologues
#3
REVIEW
Sandra Koch, Thomas F Schulz
Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.
July 26, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28395104/hhv8-kshv-positive-lymphoproliferative-disorders-and-the-spectrum-of-plasmablastic-and-plasma-cell-neoplasms-2015-sh-eahp-workshop-report-part-3
#4
Amy Chadburn, Jonathan Said, Dita Gratzinger, John K C Chan, Daphne de Jong, Elaine S Jaffe, Yasodha Natkunam, John R Goodlad
Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review immunodeficiency-related lymphoproliferative disorders with plasmablastic and plasma cell differentiation. Methods: The workshop panel reviewed human herpes virus 8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV)-associated lesions and other lesions exhibiting plasma cell differentiation, including plasmablastic proliferations with features of myeloma/plasmacytoma, plasmablastic neoplasms presenting in extranodal sites and effusion-based lymphomas, and rendered a consensus diagnosis...
February 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28335496/quantitative-analysis-of-the-kshv-transcriptome-following-primary-infection-of-blood-and-lymphatic-endothelial-cells
#5
A Gregory Bruce, Serge Barcy, Terri DiMaio, Emilia Gan, H Jacques Garrigues, Michael Lagunoff, Timothy M Rose
The transcriptome of the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) after primary latent infection of human blood (BEC), lymphatic (LEC) and immortalized (TIME) endothelial cells was analyzed using RNAseq, and compared to long-term latency in BCBL-1 lymphoma cells. Naturally expressed transcripts were obtained without artificial induction, and a comprehensive annotation of the KSHV genome was determined. A set of unique coding sequence (UCDS) features and a process to resolve overlapping transcripts were developed to accurately quantitate transcript levels from specific promoters...
March 19, 2017: Pathogens
https://www.readbyqxmd.com/read/26998055/herpes-and-polyoma-family-viruses-in-thyroid-cancer
#6
Dimitris P Stamatiou, Stavros P Derdas, Odysseas L Zoras, Demetrios A Spandidos
Thyroid cancer is considered the most common malignancy that affects the endocrine system. Generally, thyroid cancer derives from follicular epithelial cells, and thyroid cancer is divided into well-differentiated papillary (80% of cases) and follicular (15% of cases) carcinoma. Follicular thyroid cancer is further divided into the conventional and oncocytic (Hürthle cell) type, poorly differentiated carcinoma and anaplastic carcinoma. Both poorly differentiated and anaplastic carcinoma can arise either de novo, or secondarily from papillary and follicular thyroid cancer...
March 2016: Oncology Letters
https://www.readbyqxmd.com/read/26870016/kshv-genome-replication-and-maintenance
#7
REVIEW
Pravinkumar Purushothaman, Prerna Dabral, Namrata Gupta, Roni Sarkar, Subhash C Verma
Kaposi's sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a major etiological agent for multiple severe malignancies in immune-compromised patients. KSHV establishes lifetime persistence in the infected individuals and displays two distinct life cycles, generally a prolonged passive latent, and a short productive or lytic cycle. During latent phase, the viral episome is tethered to the host chromosome and replicates once during every cell division. Latency-associated nuclear antigen (LANA) is a predominant multifunctional nuclear protein expressed during latency, which plays a central role in episome tethering, replication and perpetual segregation of the episomes during cell division...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26431609/kaposi-sarcoma-associated-herpesvirus-mechanisms-of-oncogenesis
#8
REVIEW
Thomas F Schulz, Ethel Cesarman
Kaposi Sarcoma-associated Herpesvirus (KSHV, HHV8) causes three human malignancies, Kaposi Sarcoma (KS), an endothelial tumor, as well as Primary Effusion Lymphoma (PEL) and the plasma cell variant of Multicentric Castleman's Disease (MCD), two B-cell lymphoproliferative diseases. All three cancers occur primarily in the context of immune deficiency and/or HIV infection, but their pathogenesis differs. KS most likely results from the combined effects of an endotheliotropic virus with angiogenic properties and inflammatory stimuli and thus represents an interesting example of a cancer that arises in an inflammatory context...
October 2015: Current Opinion in Virology
https://www.readbyqxmd.com/read/26092770/kshv-induces-aerobic-glycolysis-and-angiogenesis-through-hif-1-dependent-upregulation-of-pyruvate-kinase-2-in-kaposi-s-sarcoma
#9
Tao Ma, Harsh Patel, Savalan Babapoor-Farrokhran, Renty Franklin, Gregg L Semenza, Akrit Sodhi, Silvia Montaner
Kaposi's sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR/HIF-1 is a fundamental pathway driving these processes through the upregulation of angiogenic and inflammatory proteins, including VEGF, ANGPTL4, and ANGPT2. Interestingly, HIF-1 has also been implicated in the upregulation of metabolic genes associated with aerobic glycolysis and the growth of solid tumors...
October 2015: Angiogenesis
https://www.readbyqxmd.com/read/24304907/the-conundrum-of-causality-in-tumor-virology-the-cases-of-kshv-and-mcv
#10
REVIEW
Patrick S Moore, Yuan Chang
Controversy has plagued tumor virology since the first tumor viruses were described over 100 years ago. Methods to establish cancer causation, such as Koch's postulates, work poorly or not at all for these viruses. Kaposi's sarcoma herpesvirus (KSHV/HHV8) and Merkel cell polyomavirus (MCV) were both found using nucleic acid identification methods but they represent opposite poles in the patterns for tumor virus epidemiology. KSHV is uncommon and has specific risk factors that contribute to infection and subsequent cancers...
June 2014: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/24286304/akt-pathway-protein-expression-in-gastrointestinal-kaposi-sarcomas-relevance-for-tumor-biology
#11
Alina Badescu, Anne Couvelard, Adriana Handra-Luca
Gastrointestinal Kaposi sarcoma (KS) is classical, but rare. The AKT signaling pathway plays a central role in G protein-coupled receptor, key protein of KS histogenesis, encoded by KSHV/HHV8. There is increasing evidence that rapamycin, acting on AKT pathway, may be useful in the treatment of KS, including in HIV patients. We aimed to study the expression pattern of AKT pathway proteins in gastrointestinal KS. Expression of AKT, 4EBP1, PTEN, mTOR was assessed in 19 gastrointestinal KS biopsies by immunohistochemistry (17 patients)...
June 2014: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/23699887/a-rare-case-of-primary-body-cavity-effusion-lymphoma-pel-presenting-as-severe-hemolytic-anemia
#12
Ameer Rasheed, Viswanath Vasudevan, Farhad Arjomand
SESSION TYPE: Cancer Case Report Posters IIPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: PEL is a rare form of Non-Hodgkin lymphoma that involves serous body cavities with lymphomatous effusions in absence of lymphadenopathy or organomegaly. Extracavity involvement is a rarity and only two cases have been described since its recognition in 1995. We report PEL presenting with hemolytic anemia, hepatomegaly and abdominal lymphadenoapthy and bowel wall thickening.CASE PRESENTATION: A 53 yr old male with HIV on ART presented with sudden onset of generalized weakness...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23368874/kaposi-sarcoma
#13
REVIEW
Oana Radu, Liron Pantanowitz
Kaposi sarcoma (KS) is a low-grade vascular tumor associated with Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. Kaposi sarcoma lesions predominantly present at mucocutaneous sites, but may involve all organs and anatomic locations. Recognized epidemiologic-clinical forms of KS include classic, African (endemic), AIDS-associated (epidemic), and iatrogenic KS. New clinical manifestations have been described, such as antiretroviral therapy-related KS regression or flares. Kaposi sarcoma lesions evolve from early (patch stage) macules into plaques (plaque stage) that grow into larger nodules (tumor stage)...
February 2013: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/23282971/kshv-hhv8-negative-effusion-based-lymphoma-a-distinct-entity-associated-with-fluid-overload-states
#14
REVIEW
Serge Alexanian, Jonathan Said, Mark Lones, Sheeja T Pullarkat
Human herpesvirus-8 (HHV8)-positive effusion-based lymphomas have been termed primary effusion lymphoma (PEL) in the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Kaposi sarcoma herpesvirus (KSHV)/HHV8-negative effusion-based lymphomas (KSHV/HHV8-negative EBLs) resembling PELs have been reported in the literature and in many cases have been (mis)classified as PEL-like lymphomas. Herein, we present a series of cases and a review of KSHV/HHV8-negative EBLs. This lymphoma, although cytomorphologically resembling PEL, is a distinct entity with characteristic clinical and pathologic features...
February 2013: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/23082307/kaposi-sarcoma-pathogenesis-a-triad-of-viral-infection-oncogenesis-and-chronic-inflammation
#15
Janet L Douglas, Jean K Gustin, Ashlee V Moses, Bruce J Dezube, Liron Pantanowitz
Kaposi sarcoma (KS) is a complex cancer that arises from the initial infection of an appropriate endothelial or progenitor cell by Kaposi Sarcoma Herpesvirus/Human Herpesvirus-8 (KSHV/HHV8). However, the majority of KS cases occur when infected patients also suffer from some coincident form of immune deregulation, providing a favorable microenvironment for tumor development. Cellular hallmarks of KS progression include both the hyper-proliferation of KSHV-infected cells and the infiltration of immune modulatory cells into KS lesions, which together result in chronic inflammation, the induction of angiogenesis and tumor growth...
2010: Translational Biomedicine
https://www.readbyqxmd.com/read/23022500/incidental-epstein-barr-virus-associated-atypical-lymphoid-proliferation-arising-in-a-left-atrial-myxoma-a-case-of-long-survival-without-any-postsurgical-treatment-and-review-of-the-literature
#16
Giovanni Bartoloni, Angela Pucci, Alexandra Giorlandino, Massimiliano Berretta, Carmelo Mignosa, Fabrizio Italia, Antonino Carbone, Vincenzo Canzonieri
We report a case of left atrial cardiac myxoma harbouring an incidental atypical B-cell lymphoid proliferation. Histology disclosed classic myxoma cells embedded in a mucopolysaccharide-rich matrix and a micronodular atypical lymphoid proliferation under the surface of the mass. Myxoma cells were immunoreactive for calretinin, while lymphoid cells expressed B lineage markers (CD 20+, CD79a), without evidence of clonality. Moreover, they were LMP1 positive; EBNA2 negative; KSHV/HHV8 negative; and, by in situ hybridization, EBER/Epstein-Barr virus (EBV) positive and Kappa and Lambda negative...
May 2013: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/22968461/how-i-treat-hhv8-kshv-related-diseases-in-posttransplant-patients
#17
Giovanni Riva, Mario Luppi, Patrizia Barozzi, Fabio Forghieri, Leonardo Potenza
Posttransplantation human herpesvirus-8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV) primary infection and/or reactivations are associated with uncommon and sometimes fatal, neoplastic, and non-neoplastic diseases. HHV8-related clinical manifestations notably range from Kaposi sarcoma (KS) to either primary effusion lymphoma or multicentric Castleman disease B-cell malignancies, and from polyclonal HHV8-positive plasmacytic lymphoproliferative disorders to bone marrow failure and peripheral cytopenias, associated or not with hemophagocytic syndromes, and to acute hepatitis syndromes...
November 15, 2012: Blood
https://www.readbyqxmd.com/read/22925337/vironome-of-kaposi-sarcoma-associated-herpesvirus-inflammatory-cytokine-syndrome-in-an-aids-patient-reveals-co-infection-of-human-herpesvirus-8-and-human-herpesvirus-6a
#18
Kristen M Tamburro, Dongmei Yang, Jessica Poisson, Yuri Fedoriw, Debasmita Roy, Amy Lucas, Sang-Hoon Sin, Nadia Malouf, Vincent Moylan, Blossom Damania, Stephan Moll, Charles van der Horst, Dirk P Dittmer
KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified concurrent high-level viremia of human herpesvirus (HHV) 8 and 6a. The HHV8 plasma viral load was 5,300,000 copies/ml, which is the highest reported to date; this despite less than five skin lesions and no HHV8 associated lymphoma. This is the first report of systemic HHV6a/KSHV co-infection in a patient...
November 10, 2012: Virology
https://www.readbyqxmd.com/read/22591071/prognosis-in-primary-effusion-lymphoma-is-associated-with-the-number-of-body-cavities-involved
#19
Jorge J Castillo, Helen Shum, Majid Lahijani, Eric S Winer, James N Butera
Primary effusion lymphoma (PEL) is a rare lymphoma associated with Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), and characterized by a malignant body cavity effusion without solid organ or nodal involvement. Prognostic factors in patients with PEL have not been systematically studied. We conducted a literature search for patients with HHV8-positive PEL to identify potential prognostic factors for survival. Our search identified 147 patients, among which 104 patients were HHV8-positive...
December 2012: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/21509436/lymph-node-based-disease-and-hhv-8-kshv-infection-in-hiv-seronegative-patients-report-of-three-new-cases-of-a-heterogeneous-group-of-diseases
#20
Antonio D'Antonio, Maria Addesso, Domenico Memoli, Pina Liguori, Roberto Cuomo, Amedeo Boscaino, Oscar Nappi
We describe three cases of lymph proliferative diseases characterized by the presence of lymphoma cells expressing the KSHV/HHV-8 antigen with or without EBV expression. The patients were HIV seronegative without serous effusions. One case was diagnosed as KSHV-germinotropic lymphoproliferative disorder due to the presence of atypical plasmablasts involving germinal centers. These plasmablasts were positive for MUM1 and vIL6, co-expressed EBV and LNA-1 of HHV-8/KSHV, and showed a polyclonal pattern of Ig gene rearrangements on PCR...
June 2011: International Journal of Hematology
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