keyword
MENU ▼
Read by QxMD icon Read
search

Antibiotic for MDR

keyword
https://www.readbyqxmd.com/read/28622861/antimicrobial-susceptibility-and-genotyping-of-staphylococcus-aureus-isolates-collected-between-1986-and-2015-from-ovine-mastitis
#1
Elisa Azara, Maria Giovanna Piras, Antonio Parisi, Sebastiana Tola
In this research, 330 Staphylococcus aureus isolates, collected in Sardinia (Italy) in the period 1986-2015 from clinical ovine mastitis and used for the preparation of inactivated autogenous vaccines, were analyzed. Susceptibility to 12 antimicrobial agents was tested by disk diffusion, according to CLSI recommendations. Resistance genes were detected by PCR assays. The most of isolates (85.2%) were susceptible to all antimicrobials tested, suggesting that did not exist change of resistance over time. Two isolates were multidrug-resistant (MDR), one of them (isolate 1496) showed resistance to seven antibiotics including oxacillin and erythromycin...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28622712/evaluation-of-the-antibacterial-and-modulatory-potential-of-%C3%AE-bisabolol-%C3%AE-cyclodextrin-and-%C3%AE-bisabolol-%C3%AE-cyclodextrin-complex
#2
Fernanda de Sousa Oliveira, Thiago Sampaio de Freitas, Rafael Pereira da Cruz, Maria do Socorro Costa, Raimundo Luiz Silva Pereira, Lucindo José Quintans-Júnior, Tatianny de Araújo Andrade, Paula Dos Passos Menezes, Bruna Maria Hipólito de Sousa, Paula Santos Nunes, Mairim Russo Serafini, Irwin Rose Alencar de Menezes, Adriano Antunes de Souza Araújo, Henrique Douglas Melo Coutinho
The present study aimed to evaluate the antibacterial and modulatory potential of α-bisabolol, β-cyclodextrin and α-bisabolol/β-cyclodextrin complex. The minimum inhibitory concentration was determined through the broth microdilution technique using the bacterial strains: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The drugs norfloxacin, imipenem and gentamicin were used in the tests, and the compounds α-bisabolol and β-cyclodextrin; all the compounds were diluted in DMSO. To obtain the minimum inhibitory concentration (MIC) a serial microdilution of the substances in volumes corresponding to the sub-inhibitory concentration (MIC/8), and microdilution with the antibiotic until the penultimate well were performed...
June 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28621642/spectrum-and-antibiotic-resistance-of-uropathogens-between-2004-and-2015-in-a-tertiary-care-hospital-in-hungary
#3
András Magyar, Béla Köves, Károly Nagy, András Dobák, Vinodh Kumar Adithyaa Arthanareeswaran, Péter Bálint, Florian Wagenlehner, Péter Tenke
PURPOSE: Surveillance of the bacterial spectrum and antibiotic-resistance patterns of locally occurring uropathogens is essential to serve as a basis for empirical treatment of urinary tract infections (UTIs), as antibiotic-resistance rates may vary geographically with significant differences between countries and regions, and with time. METHODOLOGY: We retrospectively analysed all urine samples taken in the department of urology in a tertiary care hospital in Hungary from January 2004 to December 2015...
June 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28617526/antimicrobial-resistance-gene-expression-associated-with-multidrug-resistant-salmonella-spp-isolated-from-retail-meat-in-hanoi-vietnam
#4
Minh Ngoc Nghiem, Viet Thanh Nguyen, Thu Thi Hoai Nguyen, Ton Dang Nguyen, Thuy Thi Bich Vo
The purpose of this study was to further characterize the multi-antimicrobial resistance and antibiotic resistance gene expression associated with multi-drug resistance (MDR) in Salmonella spp. isolates from retail meats in Hanoi, Vietnam. A total of 14 Salmonella spp. belonging to 9 serotypes (e.g., Warragul, London, Derby, Indiana, Meleagridis, Give, Rissen, Assine, and Typhimurium) were tested for sensitivity to 8 antibiotics. Resistance to at least one antibiotic was shown in 13 strains (92.85%). The multiple antimicrobial resistances accounted for 64...
June 2017: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28616070/persistence-of-antibiotic-resistance-plasmids-in-bacterial-biofilms
#5
Benjamin J Ridenhour, Genevieve A Metzger, Michael France, Karol Gliniewicz, Jack Millstein, Larry J Forney, Eva M Top
The emergence and spread of antibiotic resistance is a crisis in health care today. Antibiotic resistance is often horizontally transferred to susceptible bacteria by means of multidrug resistance plasmids that may or may not persist in the absence of antibiotics. Because bacterial pathogens often grow as biofilms, there is a need to better understand the evolution of plasmid persistence in these environments. Here we compared the evolution of plasmid persistence in the pathogen Acinetobacter baumannii when grown under antibiotic selection in biofilms versus well-mixed liquid cultures...
July 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28606995/synergistic-antibacterial-effect-of-silver-and-ebselen-against-multidrug-resistant-gram-negative-bacterial-infections
#6
Lili Zou, Jun Lu, Jun Wang, Xiaoyuan Ren, Lanlan Zhang, Yu Gao, Martin E Rottenberg, Arne Holmgren
Multidrug-resistant (MDR) Gram-negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance. Here, we report that five most clinically difficult-to-treat MDR Gram-negative bacteria are highly sensitive to a synergistic combination of silver and ebselen. In contrast, silver has no synergistic toxicity with ebselen on mammalian cells. The silver and ebselen combination causes a rapid depletion of glutathione and inhibition of the thioredoxin system in bacteria...
June 12, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28600080/novel-pyridyl-nitrofuranyl-isoxazolines-show-antibacterial-activity-against-multiple-drug-resistant-staphylococcus-species
#7
Pietro Picconi, Priya Prabaharan, Jennifer L Auer, Stephanie Sandiford, Francesco Cascio, Madiha Chowdhury, Charlotte Hind, Matthew E Wand, J Mark Sutton, Khondaker M Rahman
A novel series of pyridyl nitrofuranyl isoxazolines were synthesized and evaluated for their antibacterial activity against multiple drug resistant (MDR) Staphylococcus strains. Compounds with piperazine linker between the pyridyl group and isoxazoline ring showed better activity when compared to compounds without the piperazine linker. 3-Pyridyl nitrofuranyl isoxazoline with a piperazine linker was found to be more active than corresponding 2-and 4-pyridyl analogues with MICs in the range of 4-32µg/mL against MDR Staphylococcus strains...
May 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28591163/strong-influence-of-livestock-environments-on-the-emergence-and-dissemination-of-distinct-multidrug-resistant-phenotypes-among-the-population-of-non-typhoidal-salmonella
#8
Ran An, Sahar Alshalchi, Peter Breimhurst, Jeannette Munoz-Aguayo, Christian Flores-Figueroa, Sinisa Vidovic
The problem of emergence and dissemination of multidrug resistance, especially among Gram-negative bacteria, has reached alarming levels. This increases the need to develop surveillance methods that more effectively and accurately provide information about the emergence and spread of multidrug-resistant organisms. In this study, using a well-defined population of non-typhoidal Salmonella (NTS) isolates associated with avian, bovine and porcine hosts, we found that the livestock environments had a specific (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28587631/bacterial-etiologic-agents-causing-neonatal-sepsis-and-associated-risk-factors-in-gondar-northwest-ethiopia
#9
Tsehaynesh G/Eyesus, Feleke Moges, Setegn Eshetie, Biruk Yeshitela, Ebba Abate
BACKGROUND: Neonatal sepsis is a blood stream infection which is seen in the first month of life of the neonate. Bacterial profile of neonatal septicemia is constantly changing thus, current knowledge on the patterns of bacterial isolates, its antibiotic resistance profile, and associated factors, are essential to design and implement appropriate interventions. Therefore, the aim of this study was to identify bacterial etiologic agents, their antimicrobial susceptibility pattern and associated risk factors of neonatal sepsis among neonates...
June 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28581702/universal-coating-from-electrostatic-self-assembly-to-prevent-multi-drug-resistant-bacteria-colonization-on-medical-devices-solid-surfaces
#10
Wenshu Zheng, Yuexiao Jia, Wenwen Chen, Guanlin Wang, Xuefeng Guo, Xingyu Jiang
We provide a facile and scalable strategy to prepare gold nanoparticles (AuNPs)-based antibacterial coating on a variety of surfaces through electrostatic self-assembly. 4,6-diamino-2-pyrimidinethiol (DAPT, itself non-antibiotic)-conjugated AuNPs (AuDAPT) can from highly stable coating on different substrates in one-step, such coating can efficiently eradicate pathogenic gram-negative bacteria and even multidrug resistant (MDR) mutants without causing any side-effect such as cytotoxicity, hemolysis, coagulation and inflammation...
June 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28580804/burden-of-antimicrobial-resistance-in-an-era-of-decreasing-susceptibility
#11
Glenn S Tillotson, Stephen H Zinner
Antimicrobial resistance has become a global problem. Many pathogens are becoming multidrug-resistant with the attendant increased risk of failure of standard therapies and the under-recognised outcomes such as increased morbidity, mortality, length of hospitalization and costs of treatment. Areas covered: We undertook a review of the literature using standard search engines including PubMed, Google Scholar, Scopus and internet sources. Key search terms included antimicrobial resistance, antibiotic resistance, bacterial resistance, clinical outcomes, economic consequences, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Streptococcus pneumoniae and Staphylococcus aureus...
June 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28578621/drug-resistant-tuberculosis-in-zhejiang-province-china-an-updated-analysis-of-time-trends-1999-2013
#12
Beibei Wu, Le Zhang, Zhengwei Liu, Haibo He, Aizhen Pan, Fei Wang, Mingwu Zhang, Bin Chen, Zuhong Lu, Songhua Chen, Xiaomeng Wang
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) hinder the progress of TB control. OBJECTIVE: To track the trend of drug-resistant tuberculosis (DR-TB) prevalence in Zhejiang Province from 1999 to 2013, and identify risk factors of resistance to second-line drugs among MDR-TB patients. DESIGN: Four DR-TB surveys had been done in Zhejiang Province in 1999, 2004, 2008 and 2013 through questionnaires, in which demographic and epidemiological items were included...
2017: Global Health Action
https://www.readbyqxmd.com/read/28572036/draft-genome-sequence-of-a-multidrug-resistant-oxa-23-producing-acinetobacter-baumannii-st191-clinical-isolate-from-china
#13
Juan Xu, Wenping Lin, Weixing Xi, Yingyu Yao
Acinetobacter baumannii has emerged worldwide as a dominant pathogen in nosocomial infections. In this study, we report the draft genome sequence of a clinical multidrug-resistant (MDR) A. baumannii ST191 (CC92) strain. Whole-genome sequencing of the isolate was performed using an Illumina HiSeq™ 2500 system, and bioinformatics analysis was also performed. The draft genome length was 4,259,210bp, harbouring 14 gene sequences relevant to antibiotic resistance. Antimicrobial susceptibility testing revealed that the isolate was resistant to all of the tested antibiotics except for tigecycline and colistin...
May 30, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28567057/molecular-study-of-acinetobacter-baumannii-isolates-for-metallo-%C3%AE-lactamases-and-extended-spectrum-%C3%AE-lactamases-genes-in-intensive-care-unit-mansoura-university-hospital-egypt
#14
Nashwa M Alkasaby, Maysaa El Sayed Zaki
Acinetobacter baumannii (A. baumannii) has been known as a causative pathogen of hospital acquired infections. The aim of this study is to examine the presence of A. baumannii among clinical isolates from intensive care unit (ICU) in Mansoura University Hospital (MUH), its antibiotic resistance pattern, and prevalence of antibiotic resistance genes metallo-β-lactamases (MBLs) and extended-spectrum-β-lactamases (ESBLs) among A. baumannii isolates. A. baumannii was identified by colony morphology, API 20E, and confirmed by detecting the bla OXA-51-like carbapenemase gene by PCR...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28561378/epidemiology-of-bloodstream-infections-after-myeloablative-and-non-myeloablative-allogeneic-hematopoietic-stem-cell-transplantation-a-single-center-cohort-study
#15
Lars I Gjaerde, Claus Moser, Henrik Sengeløv
BACKGROUND: Patients who undergo allogeneic hematopoietic stem cell transplantation (allo-HSCT) often develop bloodstream infections (BSI). We aimed to describe the etiologies and antibiotic resistance patterns of BSI after allo-HSCT, and, since knowledge about the impact of conditioning regimen is limited, we looked at the incidence, timing, risk factors, and mortality of BSI separately for myeloablative (MA)- and non-myeloablative (NMA)-conditioned patients. METHODS: All 460 patients (207 MA- and 253 NMA-conditioned) who underwent their first allo-HSCT at our center from 2008 to 2013 were included in a historical cohort...
May 31, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28560883/a-deletion-mutation-in-nfxb-of-in-vitro-induced-moxifloxacin-resistant-pseudomonas-aeruginosa-confers-multidrug-resistance
#16
Van Chi Thai, Hoang Vy Pham, Duc Nhat Minh Nguyen, Peter Lambert, Thi Thu Hoai Nguyen
The modulation of efflux pump functions under fluoroquinolone (FQ) exposure is of great concern as it could result in occurrence of multidrug-resistant (MDR) bacterial strains. In this study, MDR mechanism in Pseudomonas aeruginosa induced via moxifloxacin (MOX) pressure was investigated. After serial MOX [concentration of 0.5 × the minimum inhibitory concentration (MIC)] exposure, the fully susceptible P. aeruginosa ATCC 9027 strain has increased its MIC not only toward MOX (1→128 mg/L) but also to other antibiotics...
May 31, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28553417/synergistic-effect-of-colistin-and-rifampin-against-multidrug-resistant-acinetobacter-baumannii-a-systematic-review-and-meta-analysis
#17
REVIEW
Maryam Mohammadi, Hatef Khayat, Koroush Sayehmiri, Setareh Soroush, Fatemeh Sayehmiri, Somayeh Delfani, Lidija Bogdanovic, Morovat Taherikalani
The existence of infections caused by multidrug resistant (MDR) Acinetobacter baumannii is a growing problem because of the difficulty to treat them. We examined the published literature and focused our analysis on the investigation of the synergism of colistin and rifampin against MDR A. baumannii isolates via systematic review and meta-analysis. A systematic literature search was performed using the following 4 databases (PubMed, Scopus, EMBASE and ISI Web of Sciences). The related articles were evaluated during the period from December 2014 to January 2015...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28553414/esbl-production-among-e-coli-and-klebsiella-spp-causing-urinary-tract-infection-a-hospital-based-study
#18
Pooja Shakya, Dhiraj Shrestha, Elina Maharjan, Vijay K Sharma, Rabin Paudyal
INTRODUCTION: Increase in extended-spectrum β-lactamases (ESBL) producing microbes in recent years has led to limitations of treatment options. This study aimed to assess the prevalence of ESBL producing E. coli and Klebsiella spp. at a tertiary hospital in Nepal. METHODS: A total of 2209 non-repetitive mid-stream urine (MSU) samples were collected during the study period (March to September 2014). Identification of the isolates was done by Gram's staining followed by biochemical tests...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28551912/-bacteria-without-borders-a-high-carriage-rate-of-antibiotic-resistant-bacteria-among-syrian-children-hospitalized-in-galilee-medical-center
#19
Diana Faour Kassem, Naama Shahar, Smadar Ocampo, Tarif Bader, Zeev Zonis, Daniel Glikman
INTRODUCTION: As the civil war in Syria enters its fifth year, the Israeli government continues to provide humanitarian aid to Syrian civilians in Israeli hospitals. Many wounded Syrian children are treated at the Galilee Medical Center (GMC). Due to the patients' incomplete medical history and increasing infection rates in Syria, contact isolation and screening cultures for multi-drug resistant bacteria (MDR's) are conducted upon admission for all Syrian children. AIMS: To describe the rate of MDR carriage in Syrian children and compare it to hospitalized Israeli children...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28550370/molecular-epidemiology-of-escherichia-coli-sequence-type-131-and-its-h30-h30-rx-subclones-recovered-from-extra-intestinal-infections-first-report-of-oxa-48-producing-st131-clone-from-iran
#20
Z Hojabri, M Mirmohammadkhani, F Kamali, K Ghassemi, S Taghavipour, O Pajand
Multidrug-resistant (MDR) O25b-ST131 clone of Escherichia coli is well established as a significant cause of extra-intestinal infections worldwide. However, there have been no studies about the prevalence of ST131 and its H30/H30Rx subclones from Iran. The prevalence of ST131 was 29.8% among phylogroups B2, D, and F of E.coli isolates recovered from extra-intestinal infections. Fifty-seven (90.4%) and six (9.6%) of isolates belonged to serogroups O25b and O16 respectively, and exhibited high rates of MDR (98...
May 27, 2017: European Journal of Clinical Microbiology & Infectious Diseases
keyword
keyword
82827
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"