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https://www.readbyqxmd.com/read/29321590/six-domoic-acid-related-compounds-from-the-red-alga-chondria-armata-and-domoic-acid-biosynthesis-by-the-diatom-pseudo-nitzschia-multiseries
#1
Yukari Maeno, Yuichi Kotaki, Ryuta Terada, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodomoic acid A (2) and B (3), N-geranyl-L-glutamic acid (4), 7'-hydroxymethyl-isodomoic acid A (5) and B (6), and N-geranyl-3(R)-hydroxy-L-glutamic acid (7), were isolated from the red alga, Chondria armata, and their structures were determined...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313078/preparation-and-application-of-a-molecularly-imprinted-monolith-for-specific-recognition-of-domoic-acid
#2
Fan Yang, Ruirui Wang, Guangshui Na, Qilun Yan, Zhongsheng Lin, Zhifeng Zhang
In this work, a molecularly imprinted monolithic column was synthesized by a facile procedure and was applied for specific recognition of domoic acid, an amnesic shellfish poison. The poly(4-vinylpyridine-co-ethylene glycol dimethacrylate) molecularly imprinted monolith was synthesized in a stainless steel column by in situ polymerization. Pentane-1,3,5-tricarboxylic acid was used as a dummy imprinting template instead of the highly toxic and expensive target molecule. It is the first time that a molecularly imprinted monolith is introduced for separation and detection of domoic acid...
January 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29295741/phytoplankton-diversity-in-adriatic-ports-lessons-from-the-port-baseline-survey-for-the-management-of-harmful-algal-species
#3
Patricija Mozetič, Monica Cangini, Janja Francé, Mauro Bastianini, Fabrizio Bernardi Aubry, Mia Bužančić, Marina Cabrini, Federica Cerino, Marijeta Čalić, Raffaele D'Adamo, Dragana Drakulović, Stefania Finotto, Daniela Fornasaro, Federica Grilli, Romina Kraus, Nataša Kužat, Daniela Marić Pfannkuchen, Živana Ninčević Gladan, Marinella Pompei, Ana Rotter, Irene Servadei, Sanda Skejić
An inventory of phytoplankton diversity in 12 Adriatic ports was performed with the port baseline survey. Particular emphasis was put on the detection of harmful aquatic organisms and pathogens (HAOP) because of their negative impact on ecosystem, human health, and the economy. Phytoplanktonic HAOP are identified as species, either native or non-indigenous (NIS), which can trigger harmful algal blooms (HAB). A list of 691 taxa was prepared, and among them 52 were classified as HAB and five as NIS. Records of toxigenic NIS (Pseudo-nitzschia multistriata, Ostreopsis species including O...
December 30, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29223596/presence-and-persistence-of-the-amnesic-shellfish-poisoning-toxin-domoic-acid-in-octopus-and-cuttlefish-brains
#4
Vanessa M Lopes, Rui Rosa, Pedro R Costa
Domoic acid (DA) is a neurotoxin that causes degenerative damage to brain cells and induces permanent short-term memory loss in mammals. In cephalopod mollusks, although DA is known to accumulate primarily in the digestive gland, there is no knowledge whether DA reaches their central nervous system. Here we report, for the first time, the presence of DA in brain tissue of the common octopus (Octopus vulgaris) and the European cuttlefish (Sepia officinalis), and its absence in the brains of several squid species (Loligo vulgaris, L...
December 5, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29208978/algae-associated-with-coral-degradation-affects-risk-assessment-in-coral-reef-fishes
#5
Mark I McCormick, Randall P Barry, Bridie J M Allan
Habitat degradation alters the chemical landscape through which information about community dynamics is transmitted. Olfactory information is crucial for risk assessment in aquatic organisms as predators release odours when they capture prey that lead to an alarm response in conspecific prey. Recent studies show some coral reef fishes are unable to use alarm odours when surrounded by dead-degraded coral. Our study examines the spatial and temporal dynamics of this alarm odour-nullifying effect, and which substratum types may be responsible...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29169567/sandwich-hybridization-probes-for-the-detection-of-pseudo-nitzschia-bacillariophyceae-species-an-update-to-existing-probes-and-a-description-of-new-probes
#6
Holly A Bowers, Roman Marin, James M Birch, Christopher A Scholin
New sandwich hybridization assay (SHA) probes for detecting Pseudo-nitzschia species (P. arenysensis, P. fraudulenta, P. hasleana, P. pungens) are presented, along with updated cross-reactivity information on historical probes (SHA and FISH; fluorescence in situ hybridization) targeting P. australis and P. multiseries. Pseudo-nitzschia species are a cosmopolitan group of diatoms that produce varying levels of domoic acid (DA), a neurotoxin that can accumulate in finfish and shellfish and transfer throughout the food web...
December 2017: Harmful Algae
https://www.readbyqxmd.com/read/29164356/investigating-the-impacts-of-treated-effluent-discharge-on-coastal-water-health-visakhapatnam-sw-coast-of-bay-of-bengal-india
#7
Aziz Ur Rahman Shaik, Haimanti Biswas, N Surendra Babu, N P C Reddy, Z A Ansari
The present study investigated the impacts of treated effluent discharge on physicochemical and biological properties of coastal waters from three pharmaceuticals situated along the coast of Visakhapatnam (SW Bay of Bengal). Seawater samples were collected (during the months of December 2013, March 2014 and April 2014) from different sampling locations (Chippada (CHP), Tikkavanipalem (TKP) and Nakkapalli (NKP)) at 0- and 30-m depths within 2-km radius (0.5 km = inner, 1 km = middle and 2 km = outer sampling circles) from the marine outfall points...
November 21, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29160864/clonal-expansion-behind-a-marine-diatom-bloom
#8
Maria Valeria Ruggiero, Domenico D'Alelio, Maria Immacolata Ferrante, Mariano Santoro, Laura Vitale, Gabriele Procaccini, Marina Montresor
Genetic diversity is what selection acts on, thus shaping the adaptive potential of populations. We studied micro-evolutionary patterns of the key planktonic diatom Pseudo-nitzschia multistriata at a long-term sampling site over 2 consecutive years by genotyping isolates with 22 microsatellite markers. We show that both sex and vegetative growth interplay in shaping intraspecific diversity. We document a brief but massive demographic and clonal expansion driven by strains of the same mating type. The analysis of an extended data set (6 years) indicates that the genetic fingerprint of P...
November 21, 2017: ISME Journal
https://www.readbyqxmd.com/read/29150543/toxicokinetics-and-physiologically-based-pharmacokinetic-modeling-of-the-shellfish-toxin-domoic-acid-in-nonhuman-primates
#9
Jing Jing, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Ariel R Topletz, Kimberly S Grant, Thomas M Burbacher, Nina Isoherranen
Domoic acid (DA), a neurotoxin, is produced by marine algae and has caused toxications worldwide in animals and humans. However, the toxicokinetics of DA has not been fully evaluated, and information is missing on the disposition of DA following oral exposures at doses that are considered safe for human consumption. In this study, toxicokinetics of DA were investigated in cynomolgus monkeys, following single doses of 5 µg/kg DA iv, 0.075 mg/kg DA po and 0.15 mg/kg DA po. Following iv dosing, DA had a systemic clearance of 124 ± 71 ml/hr/kg, volume of distribution at steady state of 131±71 ml/kg and elimination half-life of 1...
November 17, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29124474/growth-chain-formation-and-toxin-production-by-southern-brazilian-pseudo-nitzschia-isolates-under-laboratory-conditions
#10
Pedro Rebelo Wadt, Luiz Laureno Mafra, Camila Prestes Dos Santos Tavares, Luciano Felício Fernandes, Luís Antonio de Oliveira Proença
Pseudo-nitzschia is a diatom genus capable of producing the neurotoxin domoic acid (DA), which has been related to mortalities of marine vertebrates, and the amnesic shellfish poisoning (ASP) in human consumers of contaminated bivalves. This study reports DA production among Pseudo-nitzschia strains isolated from shellfish farming areas in southern Brazil. Twenty-seven cultures of potentially toxigenic Pseudo-nitzschia species were established. Growth, stepped-chain formation, and DA production were evaluated in static, intermittently illuminated (12:12 photoperiod) batch cultures for 12 selected strains, and under continuous light and/or turbulence for a single Pseudo-nitzschia calliantha strain...
November 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29122243/the-influence-of-salinity-in-the-domoic-acid-effect-on-estuarine-phytoplankton-communities
#11
Elise Van Meerssche, James L Pinckney
Toxic species of the diatom genus Pseudo-nitzschia, observed worldwide from coastal waters to the open ocean, produce the neurotoxin domoic acid (DA). DA is an important environmental and economic hazard due to shellfish contamination with subsequent effects on higher trophic levels. Previous research has demonstrated that, among other environmental factors, salinity influences the abundance and toxicity of Pseudo-nitzschia. In this study, the environmental factors driving the growth of Pseudo-nitzschia and the production of dissolved DA (dDA) in North Inlet estuary were examined...
November 2017: Harmful Algae
https://www.readbyqxmd.com/read/29064395/growth-toxin-production-and-allelopathic-effects-of-pseudo-nitzschia-multiseries-under-iron-enriched-conditions
#12
Bruna Fernanda Sobrinho, Luana Mocelin de Camargo, Leonardo Sandrini-Neto, Cristian Rafael Kleemann, Eunice da Costa Machado, Luiz Laureno Mafra
In order to assess the effects of Fe-enrichment on the growth and domoic acid (DA) production of the toxigenic diatom Pseudo-nitzschia multiseries, static cultures that received the addition of different iron (Fe) concentrations were maintained for 30 days. Intra- and extracellular DA concentrations were evaluated over time, and growth and chain-formation were compared to those of non-toxic diatoms, Bacillaria sp. Growth rates of P. multiseries (μ = 0.45-0.73 d(-1)) were similar among cultures containing different Fe concentrations...
October 24, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29031804/transcriptional-response-after-exposure-to-domoic-acid-producing-pseudo-nitzschia-in-the-digestive-gland-of-the-mussel-mytilus-galloprovincialis
#13
Antonio J Pazos, Pablo Ventoso, Roi Martínez-Escauriaza, M Luz Pérez-Parallé, Juan Blanco, Juan C Triviño, José L Sánchez
Bivalve molluscs are filter feeding species that can accumulate biotoxins in their body tissues during harmful algal blooms. Amnesic Shellfish Poisoning (ASP) is caused by species of the diatom genus Pseudo-nitzschia, which produces the toxin domoic acid. The Mytilus galloprovincialis digestive gland transcriptome was de novo assembled based on the sequencing of 12 cDNA libraries, six obtained from control mussels and six from mussels naturally exposed to domoic acid-producing diatom Pseudo-nitzschia australis...
October 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29029261/selective-enhancement-of-domoic-acid-toxicity-in-primary-cultures-of-cerebellar-granule-cells-by-lowering-extracellular-na-concentration
#14
Anabel Pérez-Gómez, David Cabrera-García, Davide Warm, Ann M Marini, Javier Salas Puig, Maria Teresa Fernández-Sánchez, Antonello Novelli
Domoic acid (DOM) is an excitatory amino acid analog of kainic acid (KA) that acts through glutamic acid (GLU) receptors, inducing a fast and potent neurotoxic response. Here we present evidence for an enhancement of excitotoxicity following exposure of cultured cerebellar granule cells to DOM in the presence of lower than physiological Na+ concentrations. The concentration of DOM that reduced by 50% neuronal survival was ̴ 3 µM in Na+-free conditions and 16 µM in presence of a physiological concentration of extracellular Na+...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29021835/progressive-changes-in-hippocampal-cytoarchitecture-in-a-neurodevelopmental-rat-model-of-epilepsy-implications-for-understanding-presymptomatic-epileptogenesis-predictive-diagnosis-and-targeted-treatments
#15
Paul B Bernard, Leslie A Ramsay, Debra S MacDonald, R Andrew Tasker
Epilepsies affect about 4% of the population and are frequently characterized by a prolonged "silent" period before the onset of spontaneous seizures. Most current animal models of epilepsy either involve acute seizure induction or kindling protocols that induce repetitive seizures. We have developed a rat model of epilepsy that is characterized by a slowly progressing series of behavioral abnormalities prior to the onset of behavioral seizures. In the current study, we further describe an accompanying progression of cytoarchitectural changes in the hippocampal formation...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29021833/what-california-sea-lions-exposed-to-domoic-acid-might-teach-us-about-autism-lessons-for-predictive-and-preventive-medicine
#16
REVIEW
Garet Paul Lahvis
Autism spectrum disorder (ASD) shares many biological and behavioral similarities with the deleterious effects of domoic acid (DA) exposure. DA is produced by marine algae and most commonly by species of Pseudo-nitzschia. Humans and marine mammals can be exposed to DA when they consume whole fish or shellfish. The mammalian fetus is highly sensitive to the deleterious effects of DA exposure. Both ASD and exposures to toxic levels of DA feature repetitive behaviors, challenges with social interaction, and seizures...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28962985/domoic-acid-in-a-marine-pelagic-food-web-exposure-of-southern-right-whales-eubalaena-australis-to-domoic-acid-on-the-pen%C3%A3-nsula-vald%C3%A3-s-calving-ground-argentina
#17
Valeria C D'Agostino, Mariana Degrati, Viviana Sastre, Norma Santinelli, Bernd Krock, Torben Krohn, Silvana L Dans, Mónica S Hoffmeyer
The gulfs that surround Península Valdés (PV), Golfo Nuevo and Golfo San José in Argentina, are important calving grounds for the southern right whale Eubalaena australis. However, high calf mortality events in recent years could be associated with phycotoxin exposure. The present study evaluated the transfer of domoic acid (DA) from Pseudo-nitzschia spp., potential producers of DA, to living and dead right whales via zooplanktonic vectors, while the whales are on their calving ground at PV. Phytoplankton and mesozooplankton (primary prey of the right whales at PV and potential grazers of Pseudo-nitzschia cells) were collected during the 2015 whale season and analyzed for species composition and abundance...
September 2017: Harmful Algae
https://www.readbyqxmd.com/read/28962980/nutrient-ratios-influence-variability-in-pseudo-nitzschia-species-diversity-and-particulate-domoic-acid-production-in-the-bay-of-seine-france
#18
Maxine Thorel, Pascal Claquin, Mathilde Schapira, Romain Le Gendre, Philippe Riou, Didier Goux, Bertrand Le Roy, Virginie Raimbault, Anne-Flore Deton-Cabanillas, Pauline Bazin, Valérie Kientz-Bouchart, Juliette Fauchot
The population dynamics of different Pseudo-nitzschia species, along with particulate domoic acid (pDA) concentrations, were studied from May 2012 to December 2013 in the Bay of Seine (English Channel, Normandy). While Pseudo-nitzschia spp. blooms occurred during the two years of study, Pseudo-nitzschia species diversity and particulate domoic acid concentrations varied greatly. In 2012, three different species were identified during the spring bloom (P. australis, P. pungens and P. fraudulenta) with high pDA concentrations (∼1400ngl(-1)) resulting in shellfish harvesting closures...
September 2017: Harmful Algae
https://www.readbyqxmd.com/read/28962972/insights-into-the-harmful-algal-flora-in-northwestern-mediterranean-coastal-lagoons-revealed-by-pyrosequencing-metabarcodes-of-the-28s-rrna-gene
#19
Daniel Grzebyk, Stéphane Audic, Bernard Lasserre, Eric Abadie, Colomban de Vargas, Béatrice Bec
This study investigated the genetic diversity of phytoplankton communities in six shallow lagoons located on the French coast of the northwestern Mediterranean Sea that represented a trophic gradient ranging from oligotrophic to hypereutrophic. The phytoplankton communities were sampled once a month from spring (May) to the beginning of autumn (September/early October) in 2012 and fractionated by size. Metabarcodes were generated from cDNAs by targeting the D1-D2 region of the 28S rRNA gene and pyrosequenced using Roche 454 technology...
September 2017: Harmful Algae
https://www.readbyqxmd.com/read/28916171/neurobehavioral-assessment-of-mice-following-repeated-oral-exposures-to-domoic-acid-during-prenatal-development
#20
Motohiro Shiotani, Toby B Cole, Sungwoo Hong, Julie Ju Young Park, William C Griffith, Thomas M Burbacher, Tomomi Workman, Lucio G Costa, Elaine M Faustman
Domoic acid (DA) is an algal toxin which has been associated with significant neurotoxicity in humans, non-human primates, rodents, and marine mammals. Developmental exposure to DA is believed to result in neurotoxicity that may persist into adulthood. DA is produced by harmful algal blooms of Pseudo-nitzschia, raising concerns about the consumption of contaminated seafood. We evaluated oral exposures to DA during pregnancy in mice. Doses of 0 (vehicle), 1 or 3mg/kg/d of DA were administered by gavage to C57BL/6J mice on gestational days 10 to 17...
September 13, 2017: Neurotoxicology and Teratology
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