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domoic OR Pseudo-nitzschia

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https://www.readbyqxmd.com/read/28916171/neurobehavioral-assessment-of-mice-following-repeated-oral-exposures-to-domoic-acid-during-prenatal-development
#1
Motohiro Shiotani, Toby B Cole, Sungwoo Hong, Julie Ju Young Park, William C Griffith, Thomas M Burbacher, Tomomi Workman, Lucio G Costa, Elaine M Faustman
Domoic acid (DA) is an algal toxin which has been associated with significant neurotoxicity in humans, non-human primates, rodents, and marine mammals. Developmental exposure to DA is believed to result in neurotoxicity that may persist into adulthood. DA is produced by harmful algal blooms of Pseudo-nitzschia, raising concerns about the consumption of contaminated seafood. We evaluated oral exposures to DA during pregnancy in mice. Doses of 0 (vehicle), 1 or 3mg/kg/d of DA were administered by gavage to C57BL/6J mice on gestational days 10 to 17...
September 12, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28875534/post-mortem-dti-reveals-altered-hippocampal-connectivity-in-wild-sea-lions-diagnosed-with-chronic-toxicosis-from-algal-exposure
#2
Peter F Cook, Gregory S Berns, Kathleen Colegrove, Shawn Johnson, Frances Gulland
Hundreds of wild California sea lions (Zalophus californianus) exposed to the algal neurotoxin domoic acid are treated in veterinary rehabilitation centers each year. Common chronic effects of toxic exposure in these animals are seizures and hippocampal damage, and they have been proposed as a natural animal model for human epilepsy. Humans with medial temporal lobe epilepsy present with white matter pathology in a number of tracts including the fornix and increased structural connectivity between the hippocampus and thalamus...
September 5, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28817087/the-preparation-and-identification-of-a-monoclonal-antibody-against-domoic-acid-and-establishment-of-detection-by-indirect-competitive-elisa
#3
Abdullah F U H Saeed, Sumei Ling, Jun Yuan, Shihua Wang
Domoic acid (DA) is a potent toxin, marine biotoxin, and primarily produced by Pseudo-nitzschia. The DA hapten was coupled with bovine serum albumin (BSA), and ovalbumin (OVA) as carrier proteins. DA-BSA conjugate was used as immunogen and DA-OVA as coating antigen. Cell fusion between spleen cells and sp2/0 myeloma cells developed 1C3 hybridoma clone producing 1C3 monoclonal antibody (mAb). Hybridoma was injected into the mice to produce ascites, and further purified by caprylic acid/ammonium sulfate method...
August 17, 2017: Toxins
https://www.readbyqxmd.com/read/28795276/topiramate-via-nmda-ampa-kainate-gabaa-and-alpha2-receptors-and-by-modulation-of-creb-bdnf-and-akt-gsk3-signaling-pathway-exerts-neuroprotective-effects-against-methylphenidate-induced-neurotoxicity-in-rats
#4
Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Tabassom Beiranvand, Shiva Mozaffari
Chronic abuse of methylphenidate (MPH) often causes neuronal cell death. Topiramate (TPM) carries neuroprotective effects, but its exact mechanism of action remains unclear. In the present study, the role of various doses of TPM and its possible mechanisms, receptors and signaling pathways involved against MPH-induced hippocampal neurodegeneration were evaluated in vivo. Thus, domoic acid (DOM) was used as AMPA/kainate receptor agonist, bicuculline (BIC) as GABAA receptor antagonist, ketamine (KET) as NMDA receptor antagonist, yohimbine (YOH) as α2 adrenergic receptor antagonist and haloperidol (HAL) was used as dopamine D2 receptor antagonist...
August 9, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28755719/understanding-the-blob-bloom-warming-increases-toxicity-and-abundance-of-the-harmful-bloom-diatom-pseudo-nitzschia-in-california-coastal-waters
#5
Zhi Zhu, Pingping Qu, Feixue Fu, Nancy Tennenbaum, Avery O Tatters, David A Hutchins
The toxic diatom genus Pseudo-nitzschia produces environmentally damaging harmful algal blooms (HABs) along the U.S. west coast and elsewhere, and a recent ocean warming event coincided with toxic blooms of record extent. This study examined the effects of temperature on growth, domoic acid toxin production, and competitive dominance of two Pseudo-nitzschia species from Southern California. Growth rates of cultured P. australis were maximal at 23°C (∼0.8d(-1)), similar to the maximum temperature recorded during the 2014-2015 warming anomaly, and decreased to ∼0...
July 2017: Harmful Algae
https://www.readbyqxmd.com/read/28755714/pseudo-nitzschia-simulans-sp-nov-bacillariophyceae-the-first-domoic-acid-producer-from-chinese-waters
#6
Yang Li, Chun Xiu Huang, Guo Shuang Xu, Nina Lundholm, Sing Tung Teng, Haiyan Wu, Zhijun Tan
The genus Pseudo-nitzschia has attracted attention because of production of the toxin, domoic acid (DA), causing Amnesic Shellfish Poisoning (ASP). Pseudo-nitzschia blooms occur frequently in Chinese coastal waters, and DA has been detected in several marine organisms, but so far no Pseudo-nitzschia strains from Chinese waters have been shown to produce DA. In this study, monoclonal Pseudo-nitzschia strains were established from Chinese coastal waters and examined using light microscopy, electron microscopy and molecular markers...
July 2017: Harmful Algae
https://www.readbyqxmd.com/read/28652566/a-high-resolution-melting-method-for-the-molecular-identification-of-the-potentially-toxic-diatom-pseudo-nitzschia-spp-in-the-mediterranean-sea
#7
Laura Pugliese, Silvia Casabianca, Federico Perini, Francesca Andreoni, Antonella Penna
The aim of this study was to develop and validate a high resolution melting (HRM) method for the rapid, accurate identification of the various harmful diatom Pseudo-nitzschia species in marine environments. Pseudo-nitzschia has a worldwide distribution and some species are toxic, producing the potent domoic acid toxin, which poses a threat to both human and animal health. Hence, it is important to identify toxic Pseudo-nitzschia species. A pair of primers targeting the LSU rDNA of the genus Pseudo-nitzschia was designed for the development of the assay and its specificity was validated using 22 control DNAs of the P...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28602251/analysis-of-sterols-in-selected-bloom-forming-algae-in-china
#8
Hui-Xia Geng, Ren-Cheng Yu, Zhen-Fan Chen, Quan-Cai Peng, Tian Yan, Ming-Jiang Zhou
Sterols, a group of stable lipid compounds, are often used as biomarkers in marine biogeochemical studies to indicate sources of organic matter. In this study, sterols in 13 species of major bloom-forming algae in China, which belong to Dinophyceae, Bacillariophyceae, Ulvophyceae, and Pelagophyceae, were analyzed with gas chromatography-mass spectrometry (GC-MS) to test their feasibility in representing different types of harmful algal blooms (HABs). It was found that (24Z)-stigmasta-5,24-dien-3β-ol (28-isofucosterol) was a major sterol component in green-tide forming macroalga Ulva prolifera...
June 2017: Harmful Algae
https://www.readbyqxmd.com/read/28535464/occurrence-of-marine-algal-toxins-in-oyster-and-phytoplankton-samples-in-daya-bay-south-china-sea
#9
Tao Jiang, Lei Liu, Yang Li, Jing Zhang, Zhijun Tan, Haiyan Wu, Tianjiu Jiang, Songhui Lu
The occurrence and seasonal variations of marine algal toxins in phytoplankton and oyster samples in Daya Bay (DYB), South China Sea were investigated. Two Dinophysis species, namely, D. caudata and D. acuminata complex, were identified as Okadaic acid (OA)/pectenotoxin (PTX) related species. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis demonstrated that 2.04-14.47 pg PTX2 per cell was the predominant toxin in single-cell isolates of D. caudata. D. acuminata was not subjected to toxin analysis...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28442131/multipoint-recognition-of-domoic-acid-from-seawater-by-dummy-template-molecularly-imprinted-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography
#10
Xiuping He, Jianlei Chen, Jiangtao Wang, Liju Tan
Due to the high cost of domoic acid (DA), different carboxylic acid compounds including indole-3-acetic acid (IAA), pyrrole-2-formic acid (PFA), pyridine-2,3-dicarboxylic anhydride (PDA), trimesitinic acid (TA) and citric acid (CA) were investigated as dummy templates for the molecularly imprinted solid-phase extraction (MISPE) for selective isolation and pre-concentration of an amnesic shellfish poison (ASP), DA. The highest binding amount of the polymers towards DA was obtained when CA was used as dummy template owing to its high hydrophilicity...
April 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28429538/finding-a-partner-in-the-ocean-molecular-and-evolutionary-bases-of-the-response-to-sexual-cues-in-a-planktonic-diatom
#11
Swaraj Basu, Shrikant Patil, Daniel Mapleson, Monia Teresa Russo, Laura Vitale, Cristina Fevola, Florian Maumus, Raffaella Casotti, Thomas Mock, Mario Caccamo, Marina Montresor, Remo Sanges, Maria Immacolata Ferrante
Microalgae play a major role as primary producers in aquatic ecosystems. Cell signalling regulates their interactions with the environment and other organisms, yet this process in phytoplankton is poorly defined. Using the marine planktonic diatom Pseudo-nitzschia multistriata, we investigated the cell response to cues released during sexual reproduction, an event that demands strong regulatory mechanisms and impacts on population dynamics. We sequenced the genome of P. multistriata and performed phylogenomic and transcriptomic analyses, which allowed the definition of gene gains and losses, horizontal gene transfers, conservation and evolutionary rate of sex-related genes...
July 2017: New Phytologist
https://www.readbyqxmd.com/read/28427569/chronic-low-level-exposure-to-the-common-seafood-toxin-domoic-acid-causes-cognitive-deficits-in-mice
#12
Kathi A Lefebvre, Preston S Kendrick, Warren Ladiges, Emma M Hiolski, Bridget E Ferriss, Donald R Smith, David J Marcinek
The consumption of one meal of seafood containing domoic acid (DA) at levels high enough to induce seizures can cause gross histopathological lesions in hippocampal regions of the brain and permanent memory loss in humans and marine mammals. Seafood regulatory limits have been set at 20mgDA/kg shellfish to protect human consumers from symptomatic acute exposure, but the effects of repetitive low-level asymptomatic exposure remain a critical knowledge gap. Recreational and Tribal-subsistence shellfish harvesters are known to regularly consume low levels of DA...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28427568/inter-and-intra-specific-growth-and-domoic-acid-production-in-relation-to-nutrient-ratios-and-concentrations-in-pseudo-nitzschia-phosphate-an-important-factor
#13
Kimberley A Lema, Marie Latimier, Élisabeth Nézan, Juliette Fauchot, Mickael Le Gac
The factors responsible for inducing the synthesis of toxins and responses from toxic phytoplankton blooms remain unclear. In this study we compare the influence of genotypic (at both the intra and interspecific levels) and environmental factors (nutrient concentration and ratio) on growth (in terms of cell densities) and domoic acid (DA) production in three Pseudo-nitzschia species: P. australis, P.pungens and P.fradulenta. A strong phosphate effect was detected. More precisely, a low initial concentration in phosphate, even at high initial nitrogen and silicate concentrations, induced the highest DA concentrations and the lowest cell densities in all strains/species studied...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28394444/development-of-a-molecular-based-index-for-assessing-iron-status-in-bloom-forming-pennate-diatoms
#14
Adrian Marchetti, Carly M Moreno, Natalie R Cohen, Irina Oleinikov, Kimberly deLong, Benjamin S Twining, E Virginia Armbrust, Robert H Lampe
Iron availability limits primary productivity in large areas of the world's oceans. Ascertaining the iron status of phytoplankton is essential for understanding the factors regulating their growth and ecology. We developed an incubation-independent, molecular-based approach to assess the iron nutritional status of specific members of the diatom community, initially focusing on the ecologically important pennate diatom Pseudo-nitzschia. Through a comparative transcriptomic approach, we identified two genes that track the iron status of Pseudo-nitzschia with high fidelity...
August 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28366401/development-of-a-qpcr-assay-for-tracking-the-ecological-niches-of-genetic-sub-populations-within-pseudo-nitzschia-pungens-bacillariophyceae
#15
Jin Ho Kim, Joo-Hwan Kim, Bum Soo Park, Pengbin Wang, Shailesh Kumar Patidar, Myung-Soo Han
Three genetic sub-populations (clade I, II and III) of Pseudo-nitzschia pungens, the potential toxic marine diatom, are known to have distinguishable growth characteristics under different culture conditions and distinct distributed patterns in the world. However, to date their exact eco-physiological traits are unrevealed in fields due to lack of the method to detect and/or measure abundances of each sub-populations, hence, the qPCR (quantitative real-time polymerase chain reaction) assay was developed to detect and quantify the P...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28366399/species-occurrence-of-the-potentially-toxigenic-diatom-genus-pseudo-nitzschia-and-the-associated-neurotoxin-domoic-acid-in-the-argentine-sea
#16
Gastón O Almandoz, Elena Fabro, Martha Ferrario, Urban Tillmann, Allan Cembella, Bernd Krock
The marine diatom genus Pseudo-nitzschia, the major known producer of the neurotoxin domoic acid (DA) responsible for the amnesic shellfish poisoning (ASP) syndrome in humans and marine mammals, is globally distributed. The genus presents high species richness in the Argentine Sea and DA has been frequently detected in the last few years in plankton and shellfish samples, but the species identity of the producers remains unclear. In the present work, the distribution and abundance of Pseudo-nitzschia species and DA were determined from samples collected on two oceanographic cruises carried out through the Argentine Sea (∼39-47°S) during summer and spring 2013...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28366394/the-relationship-between-pseudo-nitzschia-peragallo-and-domoic-acid-in-scottish-shellfish
#17
E Bresnan, R J Fryer, S Fraser, N Smith, L Stobo, N Brown, E Turrell
The diatom genus Pseudo-nitzschia (Peragallo) associated with the production of domoic acid (DA), the toxin reposnsible for amnesic shellfish poisoning, is abundant in Scottish waters. A two year study examined the relationship between Pseudo-nitzschia cells in the water column and DA concentration in blue mussels (Mytilus edulis) at two sites, and king scallops (Pecten maximus) at one site. The rate of DA uptake and depuration differed greatly between the two species with M. edulis whole tissue accumulating and depurating 7μgg(-1) (now expressed as mgkg(-1)) per week...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28342004/modulatory-effects-of-terminalia-arjuna-against-domoic-acid-induced-toxicity-in-caco-2-cell-line
#18
E M Ramya, G Phani Kumar, T Anand, K R Anilakumar
Domoic acid is a potent marine algal toxin produced by diatomic genus of Pseudo-nitzschia causing amnesic shell fish poisoning. Domoic acid toxicosis mainly involves excitotoxic effects coupled with oxidative stress. The present study was aimed to evaluate the protective effects of hydro-alcoholic extract of Terminalia arjuna (TA) against domoic acid induced toxic effects in Caco-2 cell line. It was observed that the toxicity induced by domoic acid in Caco-2 cells was mediated by oxidative insult leading to morphological changes, DNA damage and apoptosis...
August 2017: Cytotechnology
https://www.readbyqxmd.com/read/28303313/significant-change-in-marine-plankton-structure-and-carbon-production-after-the-addition-of-river-water-in-a-mesocosm-experiment
#19
E Fouilland, A Trottet, C Alves-de-Souza, D Bonnet, T Bouvier, M Bouvy, S Boyer, L Guillou, E Hatey, H Jing, C Leboulanger, E Le Floc'h, H Liu, S Mas, B Mostajir, J Nouguier, D Pecqueur, E Rochelle-Newall, C Roques, C Salles, M-G Tournoud, C Vasseur, F Vidussi
Rivers are known to be major contributors to eutrophication in marine coastal waters, but little is known on the short-term impact of freshwater surges on the structure and functioning of the marine plankton community. The effect of adding river water, reducing the salinity by 15 and 30%, on an autumn plankton community in a Mediterranean coastal lagoon (Thau Lagoon, France) was determined during a 6-day mesocosm experiment. Adding river water brought not only nutrients but also chlorophyceans that did not survive in the brackish mesocosm waters...
March 16, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28285260/microsatellite-markers-for-population-genetic-applications-in-the-domoic-acid-producing-diatom-pseudo-nitzschia-australis-frenguelli-bacillariophyceae
#20
Nicolaus G Adams, Piper Schwenke, G Jason Smith, Vera L Trainer
Microsatellites are commonly used markers in population genetics and are increasingly being employed to determine population structure in phytoplankton populations. We have developed seven polymorphic microsatellite markers for the domoic-acid producing diatom Pseudo-nitzschia australis. Using these markers, thirty P. australis isolates were genotyped, 10 isolates were from Monterey Bay, California and 20 were from off the northern coast of Oregon. The number of alleles per locus ranged from two to eight and observed heterozygosities ranged from 0...
January 26, 2017: Protist
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