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Osteoarthritis and light

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https://www.readbyqxmd.com/read/27890430/tar-dna-binding-protein-43-inhibits-inflammatory-response-and-protects-chondrocyte-function-by-modulating-rack1-expression-in-osteoarthritis
#1
Yongming Huang, Qiming Huang, Haitao Su, Xiujun Mai, Enhui Feng, Zhenwu Cao, Xiuyun Zeng
BACKGROUND: TAR DNA-binding protein-43 (TDP-43, transactive response DNA binding protein 43kDa) accumulates in the cytoplasm of affected neurons and glia, as large inclusions of stress granules (SGs). However, the mechanism of TDP-43 interaction with the target genes and its specific role in osteoarthritis (OA) progression is still unknown. The goal of this study was to identify the role of TDP-43 in OA progression by modulating its target genes. METHODS: MSCs were transfected with TDP-43 gene lentivirus...
November 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27845712/the-role-of-mirnas-in-common-inflammatory-arthropathies-osteoarthritis-and-gouty-arthritis
#2
REVIEW
Panagiota Papanagnou, Theodora Stivarou, Maria Tsironi
MicroRNAs (miRNAs) are small, non-coding RNA species that are highly evolutionarily conserved, from higher invertebrates to man. Up to 1000 miRNAs have been identified in human cells thus far, where they are key regulators of the expression of numerous targets at the post-transcriptional level. They are implicated in various processes, including cell differentiation, metabolism, and inflammation. An expanding list of miRNAs is known to be involved in the pathogenesis of common, non-autoimmune inflammatory diseases...
November 11, 2016: Biomolecules
https://www.readbyqxmd.com/read/27820852/osteoarthritis-in-the-knee-joints-of-g%C3%A3-ttingen-minipigs-after-resection-of-the-anterior-cruciate-ligament-missing-correlation-of-mri-gene-and-protein-expression-with-histological-scoring
#3
Gregor Reisig, Michael Kreinest, Wiltrud Richter, Mechthild Wagner-Ecker, Dietmar Dinter, Ulrike Attenberger, Barbara Schneider-Wald, Stefan Fickert, Markus L Schwarz
INTRODUCTION: The Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. MATERIALS AND METHODS: The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control...
2016: PloS One
https://www.readbyqxmd.com/read/27808445/chemokines-and-inflammation-in-osteoarthritis-insights-from-patients-and-animal-models
#4
REVIEW
Carla R Scanzello
Evidence has been building that the pathologic drive for development of osteoarthritis (OA) involves more than simple mechanical "wear and tear." Inflammatory mechanisms play an important role in the tissue response to joint injury, and are involved in development of post-traumatic OA. Inflammation also appears integral to the progression of OA, whether post-traumatic or spontaneous, contributing to the evolution of joint tissue degradation and remodeling as well as joint pain. Both patient-based studies and in vivo models of disease have shed light on a number of inflammatory pathways and mediators that impact various aspects of this disease, both structurally and symptomatically...
November 3, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27727249/microrna-140-inhibits-inflammation-and-stimulates-chondrogenesis-in-a-model-of-interleukin-1%C3%AE-induced-osteoarthritis
#5
Tommy A Karlsen, Gustavo Antonio de Souza, Bjørn Ødegaard, Lars Engebretsen, Jan E Brinchmann
Osteoarthritis is a serious disease of articular cartilage. The pathogenic factors contributing to this disorder are inflammation, extracellular matrix degradation and failure to rebuild the articular cartilage. Preclinical studies suggest that microRNA-140 may play a protective role in osteoarthritis development, but little is known about the mechanism by which this occurs. Here we present the results of forced expression of microRNA-140 in an in vitro model of osteoarthritis, evaluated by global proteomics analysis...
October 11, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27727159/preparation-of-low-molecular-weight-chondroitin-sulfates-screening-of-a-high-anti-complement-capacity-of-low-molecular-weight-chondroitin-sulfate-and-its-biological-activity-studies-in-attenuating-osteoarthritis
#6
Lian Li, Yan Li, Danyang Feng, Linghua Xu, Fengxin Yin, Hengchang Zang, Chunhui Liu, Fengshan Wang
Chondroitin sulfate (CS) plays important roles in the complement system. However, the CS structure is complicated due to different sources and the number and positions of sulfate groups. The objective of this study was to prepare different low molecular weight chondroitin sulfates (LMWCSs) and to investigate the biological activity in anti-complement capacity. A series of LMWCSs was prepared from different sources and characterized by ultraviolet-visible (UV) spectroscopy, high-performance liquid chromatography (HPLC), size exclusion chromatography-multiangle laser light scattering (SEC-MALLS) and nuclear magnetic resonance (NMR) spectroscopy...
October 11, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27703331/the-spice-for-joint-inflammation-anti-inflammatory-role-of-curcumin-in-treating-osteoarthritis
#7
Kok-Yong Chin
Osteoarthritis is a degenerative disease of the joint affecting aging populations worldwide. It has an underlying inflammatory cause, which contributes to the loss of chondrocytes, leading to diminished cartilage layer at the affected joints. Compounds with anti-inflammatory properties are potential treatment agents for osteoarthritis. Curcumin derived from Curcuma species is an anti-inflammatory compound as such. This review aims to summarize the antiosteoarthritic effects of curcumin derived from clinical and preclinical studies...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27671326/hip-osteoarthritis-etiopathogenesis-and-implications-for-management
#8
REVIEW
Nicholas J Murphy, Jillian P Eyles, David J Hunter
Highly prevalent among the elderly, hip osteoarthritis (OA) carries a heavy burden of disease. Guidelines for the management of hip OA are often extrapolated from knee OA research, despite clear differences in the etiopathogenesis and response to treatments of OA at these sites. We propose that hip OA requires specific attention separate from other OA phenotypes. Our understanding of the etiopathogenesis of hip OA has seen significant advance over the last 15 years, since Ganz and colleagues proposed femoroacetabular impingement (FAI) as an important etiological factor...
November 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27667531/are-midterm-patient-reported-outcome-measures-between-rotating-platform-mobile-bearing-prosthesis-and-medial-pivot-prosthesis-different-a-minimum-of-5-year-follow-up-study
#9
Nam Y Choi, Yong In, Jae-Ho Bae, Jung-Hoon Do, Seung J Chung, In J Koh
BACKGROUND: Both rotating-platform (RP) mobile-bearing and medial-pivot (MP) fixed-bearing prostheses allow axial femorotibial rotation using a highly conforming polyethylene insert. However, limited comparative data are available between the 2 designs. This study was performed to compare the midterm clinical outcomes and patient-reported outcome measures (PROMs) of RP and MP prostheses. METHODS: We retrospectively reviewed the records of 52 total knee arthroplasties using RP mobile-bearing prosthesis and 49 total knee arthroplasties using MP fixed prosthesis with a minimum follow-up period of 5 years...
August 31, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27660935/detection-of-calcium-crystals-in-knee-osteoarthritis-synovial-fluid-a-comparison-between-polarized-light-and-scanning-electron-microscopy
#10
Paola Frallonardo, Francesca Oliviero, Luca Peruzzo, Leonardo Tauro, Anna Scanu, Paola Galozzi, Roberta Ramonda, Leonardo Punzi
BACKGROUND: The identification of calcium crystals in synovial fluid (SF) of patients with osteoarthritis (OA) represents an important step in understanding the role of these crystals in synovial inflammation and disease progression. OBJECTIVES: This study aimed to investigate the presence of calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals in SF collected from patients with symptomatic knee OA by scanning electron microscopy (SEM) coupled to x-ray energy dispersive spectroscopy, compensated polarized light microscopy (CPLM), and alizarin red staining...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27633696/-the-pain-must-not-be-taken-lightly
#11
Claire Trochet
Michèle D. is aged 70 and has been suffering from osteoarthritis for many years. She describes her journey.
August 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/27614684/ambient-light-based-optical-biosensing-platform-with-smartphone-embedded-illumination-sensor
#12
Yoo Min Park, Yong Duk Han, Hyeong Jin Chun, Hyun C Yoon
We present a hand-held optical biosensing system utilizing a smartphone-embedded illumination sensor that is integrated with immunoblotting assay method. The smartphone-embedded illumination sensor is regarded as an alternative optical receiver that can replaces the conventional optical analysis apparatus because the illumination sensor can respond to the ambient light in a wide range of wavelengths, including visible and infrared. To demonstrate the biosensing applicability of our system employing the enzyme-mediated immunoblotting and accompanying light interference, various types of ambient light conditions including outdoor sunlight and indoor fluorescent were tested...
September 2, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27499316/is-there-crosstalk-between-subchondral-bone-cartilage-and-meniscus-in-the-pathogenesis-of-osteoarthritis
#13
O Şahap Atik, Deniz Erdoğan, Cemile Merve Seymen, Hasan Hüseyin Bozkurt, Gülnur Take Kaplanoğlu
OBJECTIVES: This study aims to investigate if there is any crosstalk between subchondral bone, cartilage, and meniscus in the pathogenesis of osteoarthritis. PATIENTS AND METHODS: Twelve female patients (mean age 64 years; range 59 to 71 years) with osteoarthritis in medial compartment were included in the study. The samples of subchondral bone, cartilage and meniscus were obtained during total knee arthroplasty. Degenerated tissue samples obtained from medial compartment were used as the experimental group (12 samples of subchondral bone and cartilage, 1x1 cm each; and 12 samples of meniscus, 1x1 cm each)...
August 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27393498/effects-of-a-novel-foot-ankle-orthosis-in-the-non-operative-treatment-of-unicompartmental-knee-osteoarthritis
#14
Björn Menger, Andreas Kannenberg, Wolf Petersen, Thore Zantop, Ingo Rembitzki, Hartmut Stinus
INTRODUCTION: Unloader braces are non-surgical treatment options for patients with unicompartmental knee osteoarthritis (OA). However, many patients do not adhere to brace treatment because of complications related to discomfort and poor fit. An alternative to knee bracing is an ankle-foot orthosis (AFO) with a lever arm that presses the lower leg into valgus or varus. The aim of this study is to evaluate the clinical benefits of this AFO for patients with unicompartmental knee OA. MATERIALS AND METHODS: Twenty-three patients with knee OA were enrolled in this observational study...
September 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27387445/immune-response-and-innervation-signatures-in-aseptic-hip-implant-loosening
#15
Daniel M Vasconcelos, Manuel Ribeiro-da-Silva, António Mateus, Cecília Juliana Alves, Gil Costa Machado, Joana Machado-Santos, Diogo Paramos-de-Carvalho, Inês S Alencastre, Rui Henrique, Gilberto Costa, Mário A Barbosa, Meriem Lamghari
BACKGROUND: Aseptic loosening (AL) of hip prosthesis presents inflammation and pain as sign and symptom similarly to arthritis pathologies. Still, the immune and innervation profiles in hip AL remain unclear and their interplay is poorly explored. Herein, local tissue inflammatory response, sensory and sympathetic innervation as well as associated local mediators were assessed in hip joint microenvironment underlying AL and compared to osteoarthritis (OA). METHODS: Histopathological analysis, immune cells (macrophages, T, B cells and PMNs) as well as sensory and sympathetic nerve fibers (SP(+), CGRP(+), TH(+)) distribution and profiles were analyzed on tissues retrieved from patients with failed hip prostheses due to AL (n = 20) and hip OA (n = 15) by immunohistochemistry...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27301478/intra-articular-injection-of-torin-1-reduces-degeneration-of-articular-cartilage-in-a-rabbit-osteoarthritis-model
#16
N-T Cheng, A Guo, Y-P Cui
OBJECTIVES: Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhibitor of mTOR which can cause induction of autophagy, is similar to rapamycin, on articular cartilage degeneration in a rabbit osteoarthritis model and to investigate the mechanism of Torin 1's effects on experimental OA...
June 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27257981/single-versus-multiple-dose-hyaluronic-acid-comparison-of-the-results
#17
Demirhan Dıraçoğlu, Tuğba Baysak Tunçay, Tuğba Şahbaz, Cihan Aksoy
OBJECTIVE: The purpose of this study was to compare the effectiveness of three injections of standard linear HA versus single injection of lightly cross-linking HA in patients with knee OA. METHODS: Forty subjects were randomized into two groups. The first group received single dose intraarticular injection of 4 ml lightly cross-linking sodium hyaluronate (Monovisc), and the second group received three consecutive intraarticular injections of 2.5 ml standard linear sodium hyaluronate (Adant) with one week intervals...
November 21, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27178054/gold-nanoparticles-of-diameter-13%C3%A2-nm-induce-apoptosis-in-rabbit-articular-chondrocytes
#18
Hao Huang, Ying-Yao Quan, Xiao-Ping Wang, Tong-Sheng Chen
Gold nanoparticles (AuNPs) have been widely used in biomedical science including antiarthritic agents, drug loading, and photothermal therapy. In this report, we studied the effects of AuNPs with diameters of 3, 13, and 45 nm, respectively, on rabbit articular chondrocytes. AuNPs were capped with citrate and their diameter and zeta potential were measured by dynamic light scattering (DLS). Cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay after the rabbit articular chondrocytes were pre-incubated with 3, 13, and 45 nm AuNPs, respectively, for 24 h...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27058744/chondrogenic-effect-of-intra-articular-hypertonic-dextrose-prolotherapy-in-severe-knee-osteoarthritis
#19
Gastón Andrés Topol, Leandro Ariel Podesta, Kenneth Dean Reeves, Marcia Mallma Giraldo, Lanny L Johnson, Raul Grasso, Alexis Jamín, Tom Clark, David Rabago
BACKGROUND: Dextrose injection is reported to improve knee osteoarthritis (KOA)-related clinical outcomes, but its effect on articular cartilage is unknown. A chondrogenic effect of dextrose injection has been proposed. OBJECTIVE: To assess biological and clinical effects of intra-articular hypertonic dextrose injections (prolotherapy) in painful KOA. DESIGN: Case series with blinded arthroscopic evaluation before and after treatment. SETTING: Physical medicine and day surgery practice...
April 4, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/26991574/extreme-postinjection-flare-in-response-to-intra-articular-triamcinolone-acetonide-kenalog
#20
Porter Young, Kelly C Homlar
As intra-articular corticosteroid injections (CSIs) are a common treatment for osteoarthritis, physicians must well understand their potential side effects. Postinjection flares are an acute side effect of intra-articular CSIs, with symptoms ranging from mild joint effusion to disabling pain. The present case involved a severe postinjection flare that occurred after the patient, a 56-year-old woman with moderate osteoarthritis in the left knee, received 2 mL of 1% lidocaine and 2 mL (40 mg) of triamcinolone acetonide (Kenalog)...
March 2016: American Journal of Orthopedics
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