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https://www.readbyqxmd.com/read/29777340/2017-update-of-the-turkish-league-against-rheumatism-tlar-evidence-based-recommendations-for-the-management-of-knee-osteoarthritis
#1
REVIEW
Tiraje Tuncer, Fatih Hasan Cay, Lale Altan, Gulcan Gurer, Cahit Kacar, Suheda Ozcakir, Sahap Atik, Figen Ayhan, Berrin Durmaz, Nurten Eskiyurt, Hakan Genc, Yesim GokceKutsal, Rezzan Gunaydin, Simin Hepguler, Sami Hizmetli, Taciser Kaya, Yesim Kurtais, Merih Saridogan, Dilsad Sindel, Serap Sutbeyaz, Omer Faruk Sendur, Hatice Ugurlu, Zeliha Unlu
In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee was composed of 22 physical medicine and rehabilitation specialists (4 have rheumatology subspeciality also) and an orthopaedic surgeon. Systematic literature search were applied on Pubmed, Embase, Cochrane and Turkish Medical Index for the dates between January the 1st 2012 and January the 29th of 2015...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29760787/inverted-rearfoot-posture-in-subjects-with-coexisting-patellofemoral-osteoarthritis-in-medial-knee-osteoarthritis-an-exploratory-study
#2
Hirotaka Iijima, Hiroshi Ohi, Naoto Fukutani, Tomoki Aoyama, Eishi Kaneda, Kaoru Abe, Masaki Takahashi, Shuichi Matsuda
Background: While abnormal rearfoot posture and its relationship to patellofemoral (PF) pain has been thoroughly discussed in the literature, its relationship to patellofemoral osteoarthritis (PFOA) has not been determined. This study aimed to examine whether rearfoot posture is associated with a higher prevalence of radiographic PFOA in a compartment-specific manner in patients with medial tibiofemoral osteoarthritis (TFOA). Methods: Participants from orthopedic clinics ( n  = 68, age 56-90 years, 75...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29747006/bioinspired-bone-therapies-using-naringin-applications-and-advances
#3
REVIEW
Pedro Lavrador, Vitor M Gaspar, João F Mano
The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided...
May 7, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29729332/does-the-intensity-of-daily-walking-matter-for-protecting-against-the-development-of-a-slow-gait-speed-in-people-with-or-at-high-risk-of-knee-osteoarthritis-an-observational-study
#4
Sally Am Fenton, Tuhina Neogi, Dorothy Dunlop, Michael Nevitt, Michael Doherty, Joan L Duda, Rainer Klocke, Abhishek Abhishek, Alison Rushton, Weiya Zhang, Cora E Lewis, James Torner, George Kitas, Daniel K White
OBJECTIVE: Knee osteoarthritis (OA) is a risk factor for a decline in gait speed. Daily walking reduces the risk of developing slow gait speed and future persistent functional limitation. However, the protective role of walking intensity is unclear. We investigated the association of substituting time spent not walking, with walking at light and moderate-to-vigorous intensities for incident slow gait over two-years, among people with or at high risk of knee osteoarthritis (OA). METHOD: We used baseline and two-year follow-up data from the Multicenter Osteoarthritis (MOST) study (n=1731) and the Osteoarthritis Initiative (OAI, n=1925)...
May 2, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29687923/quantitative-susceptibility-mapping-of-articular-cartilage-ex-vivo-findings-at-multiple-orientations-and-following-different-degradation-treatments
#5
Olli Nykänen, Lassi Rieppo, Juha Töyräs, Ville Kolehmainen, Simo Saarakkala, Karin Shmueli, Mikko J Nissi
PURPOSE: We investigated the feasibility of quantitative susceptibility mapping (QSM) for assessing degradation of articular cartilage by measuring ex vivo bovine cartilage samples subjected to different degradative treatments. Specimens were scanned at several orientations to study if degradation affects the susceptibility anisotropy. T2*-mapping, histological stainings, and polarized light microscopy were used as reference methods. Additionally, simulations of susceptibility in layered geometry were performed...
April 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29605382/physical-activity-is-associated-with-changes-in-knee-cartilage-microstructure-data-from-the-osteoarthritis-initiative
#6
Eni Halilaj, Trevor J Hastie, Garry E Gold, Scott L Delp
OBJECTIVE: The purpose of this study was to determine if there is an association between objectively measured physical activity and longitudinal changes in knee cartilage microstructure. METHODS: We used accelerometry and T2 -weighted Magnetic Resonance Imaging data from the Osteoarthritis Initiative, restricting the analysis to men aged 45 - 60 years, with a BMI of 25 - 27 kg/m2 and no radiographic evidence of knee osteoarthritis. After computing four-year changes in mean T2 relaxation time for six femoral cartilage regions and mean daily times spent in the sedentary, light, moderate, and vigorous activity ranges, we performed canonical correlation analysis to find a linear combination of times spent in different activity intensity ranges (Activity Index) that was maximally correlated with a linear combination of regional changes in cartilage microstructure (Cartilage Microstructure Index)...
March 29, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29556896/mesenchymal-stem-cells-in-the-musculoskeletal-system-from-animal-models-to-human-tissue-regeneration
#7
REVIEW
Klemen Čamernik, Ariana Barlič, Matej Drobnič, Janja Marc, Matjaž Jeras, Janja Zupan
The musculoskeletal system includes tissues that have remarkable regenerative capabilities. Bone and muscle sustain micro-damage throughout the lifetime, yet they continue to provide the body with the support that is needed for everyday activities. Our current understanding is that the regenerative capacity of the musculoskeletal system can be attributed to the mesenchymal stem/ stromal cells (MSCs) that reside within its different anatomical compartments. These MSCs can replenish various tissues with progenitor cells to form functional cells, such as osteoblasts, chondrocytes, myocytes, and others...
March 20, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29516278/calcium-containing-crystals-and-osteoarthritis-an-unhealthy-alliance
#8
REVIEW
Richard Conway, Geraldine M McCarthy
PURPOSE OF REVIEW: Osteoarthritis (OA) is the most common form of joint disease globally and is associated with significant morbidity and disability. Increasing evidence points to an important inflammatory component in the development and progression of OA. The precise pathways involved in OA inflammatory processes remain to be clarified. Basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP) crystals can induce inflammation and arthritis and recent studies point to a potential pathogenic role in OA...
March 8, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29513755/mast-cells-are-important-regulator-of-acupoint-sensitization-via-the-secretion-of-tryptase-5-hydroxytryptamine-and-histamine
#9
Ning Ding, Jing Jiang, Pingping Qin, Qiaoxia Wang, Jiatong Hu, Zhigang Li
Mast cells (MCs) play a crucial role in mediating the establishment of networks among the circulatory, nervous and immune system at acupoints. However, the changes which occur in MCs during acupoint sensitization, i.e. the dynamic transformation of an acupoint from a "silenced" to an "activated" status, remain uncharacterized. To investigate the morphological and functional changes of MCs as an aid to understanding the cellular mechanism underlying acupoint sensitization, a rat model of knee osteoarthritis (OA) was induced by an injection of mono-iodoacetate (MIA) on day 0...
2018: PloS One
https://www.readbyqxmd.com/read/29485013/development-of-microemulsion-based-nabumetone-transdermal-delivery-for-treatment-of-arthritis
#10
Swati Jagdale, Gokul Deore, Anuruddha Chabukswar
Background Nabumetone is biopharmaceutics classification system (BCS) class II drug, widely used in the treatment of osteoarthritis and rheumatoid arthritis. The most frequently reported adverse reactions for the drug involve disturbance in gastrointestinal tract , diarrhea, dyspepsia and abdominal pain. Microemulgel has advantages of microemulsion for improving solubility for hydrophobic drug. Patent literature had shown that the work for drug has been carried on spray chilling, enteric coated tablet, and topical formulation which gave idea for present research work for development of transdermal delivery...
February 26, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29480363/ultrasound-plus-low-level-laser-therapy-for-knee-osteoarthritis-rehabilitation-a-randomized-placebo-controlled-trial
#11
Fernanda Rossi Paolillo, Alessandra Rossi Paolillo, Jessica Patrícia João, Daniele Frascá, Marcelo Duchêne, Herbert Alexandre João, Vanderlei Salvador Bagnato
This study evaluated the synergistic effects of ultrasound (US) and low-level laser therapy (LLLT) with or without therapeutic exercises (TE) in women with knee osteoarthritis. Forty-two Caucasian women with knee osteoarthritis were allocated into three groups: (1) the placebo group who did not perform TE, but the prototype without emitting light or ultrasonic waves was applied, (2) the US + LLLT group in which only the prototype was applied and (3) the TE + US + LLLT group that performed TE before the prototype was applied...
May 2018: Rheumatology International
https://www.readbyqxmd.com/read/29473665/lower-limb-muscle-function-during-gait-in-varus-mal-aligned-osteoarthritis-patients
#12
Prasanna Sritharan, Yi-Chung Lin, Sara E Richardson, Kay M Crossley, Trevor B Birmingham, Marcus G Pandy
This study quantified the contributions by muscular, gravitational and inertial forces to the ground reaction force (GRF) and external knee adduction moment (EKAM) for knee osteoarthritis (OA) patients and controls walking at similar speeds. Gait data for 39 varus mal-aligned medial knee OA patients and 15 controls were input into musculoskeletal models to calculate the contributions of individual muscles and gravity to the fore-aft (progression), vertical (support), and mediolateral (balance) GRF, and the EKAM...
February 23, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29434766/microrna-17-5p-contributes-to-osteoarthritis-progression-by-binding-p62-sqstm1
#13
Huihui Li, Daoyi Miao, Qi Zhu, Jianghua Huang, Guangxian Lu, Weiguo Xu
Autophagy has been reported to be widely involved in the pathogenesis of osteoarthritis (OA). Increasing evidence suggested the important role of microRNAs (miRs) in the progression of OA. However, the functional role of miR-17-5p in OA development has remained to be fully elucidated. First, a mouse model of OA was established and the relative level of miR-17-5p was determined using PCR. Safranin O-fast green staining was applied to determine cartilage degeneration. TargetScan software and a dual luciferase reporter assay were applied to determine potential target genes of miR-17-5P...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29424905/study-the-relevance-between-inflammatory-factors-and-estradiol-and-their-association-with-knee-osteoarthritis-in-postmenopausal-women
#14
Y-P Liu, J Li, S-B Xin, J X
OBJECTIVE: To investigate whether serum levels of inflammatory factors and estradiol (E2) are involved in the pathogenesis of postmenopausal women with knee osteoarthritis (OA). PATIENTS AND METHODS: 58 randomly patients diagnosed with postmenopausal knee OA that underwent orthopedic surgery from October 2013 to October 2016 in our hospital were selected. These patients, considered as the experimental group, according to the degree of cartilage damage, were divided into light, medium and heavy groups...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29415582/date-seed-oil-loaded-niosomes-development-optimization-and-anti-inflammatory-effect-evaluation-on-rats
#15
Mahmoud S Soliman, Fathy I Abd-Allah, Talib Hussain, Noha M Saeed, Hossam S El-Sawy
OBJECTIVE: An optimized date seed oil (DSO) loaded niosomes was formulated. SIGNIFICANCE: Maximize the extract anti-inflammatory efficacy and govern its release characteristics from nanoparticles for osteoarthritis prevention and treatment purposes. METHODS: By using Box-Behnken Design, the effect of three formulation factors on the entrapment efficiency percentage (Y1 ), initial DSO release percentage after 2 h (Y2 ), and cumulative DSO release percentage of DSO after 12 h (Y3 ), were optimized and studied...
July 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29361275/individuals-with-varus-thrust-do-not-increase-knee-adduction-when-running-with-body-borne-load
#16
Tyler N Brown, Jonathan T Kaplan, Sarah E Cameron, Kayla D Seymore, John W Ramsay
Osteoarthritis (OA) is a common occupational hazard for service members. This study quantified how body borne load impacts knee biomechanics for participants who do and do not present varus thrust (range of knee adduction motion exhibited from heel strike to mid-stance (0-51%)) during over-ground running. Eighteen (9 varus thrust and 9 control) military personnel had knee biomechanics recorded when running with three load conditions (light, ∼6 kg, medium, 15% BW, and heavy, 30% BW). Subject-based means for knee biomechanics were calculated and submitted to a RM ANOVA to test the main effects and possible interactions between load and varus thrust group...
March 1, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29359666/enhancing-the-intestinal-permeation-of-the-chondroprotective-nutraceuticals-glucosamine-sulphate-and-chondroitin-sulphate-using-conventional-and-modified-liposomes
#17
Ahmed M Agiba, Maha Nasr, Sameh Abdel-Hamid, Ahmed B Eldin, Ahmed S Geneidi
Liposomes are promising systems for the delivery of macromolecules and poorly absorbed drugs, owing to their ability to compartmentalize drugs, their biodegradability and biocompatibility. The aim of the present study was to formulate and evaluate conventional and modified glucosamine sulphate (GluS) and chondroitin sulphate (CS) liposomal formulations, to enhance their oral permeation for treatment of osteoarthritis (OA). Liposomal formulations were prepared by the thin-film hydration method using two types of phospholipids; Epikuron 200© and Epikuron 200© SH, and three permeation enhancers; poloxamer 407, cetylpyridinium chloride, and sodium deoxycholate...
January 22, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29286133/hydroxytyrosol-inhibits-the-inflammatory-response-of-osteoarthritis-chondrocytes-via-sirt6-mediated-autophagy
#18
Li-Qiang Zhi, Shu-Xin Yao, Hong-Liang Liu, Meng Li, Ning Duan, Jian-Bing Ma
Osteoarthritis (OA) is a common degenerative joint disease. Inflammation may exaggerate the catabolism and degeneration in the pathogenesis of OA. Hydroxytyrosol (HT) has been used in the management of inflammatory diseases. In addition, reports have revealed that autophagy was a therapeutic target of diseases caused by inflammation. Sirtuin 6 (SIRT6) has also been demonstrated to prevent OA development by reducing both the inflammatory response and chondrocyte senescence. However, the roles of SIRT6 and autophagy in cartilage and its underlying anti‑inflammatory mechanism are unknown...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29246142/association-between-metabolic-syndrome-and-knee-osteoarthritis-a-cross-sectional-study
#19
Dong-Xing Xie, Jie Wei, Chao Zeng, Tuo Yang, Hui Li, Yi-Lun Wang, Hui-Zhong Long, Zi-Ying Wu, Yu-Xuan Qian, Kang-Hua Li, Guang-Hua Lei
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disease in China. The aim of this study was to examine the association between metabolic syndrome (MetS) and knee OA in a population-based Chinese study. METHODS: Data included in this analysis is from a cross-sectional study, i.e., the Xiangya Hospital Health Management Center Study. MetS was diagnosed according to the criteria defined by the Chinese Diabetes Society. Radiographic knee OA was defined as changes equivalent to Kellgren-Lawrence (K-L) grade 2 or above at least one side...
December 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29197177/parametric-imaging-of-collagen-structural-changes-in-human-osteoarthritic-cartilage-using-optical-polarization-tractography
#20
Mohammadreza Ravanfar, Ferris M Pfeiffer, Chantelle C Bozynski, Yuanbo Wang, Gang Yao
Collagen degeneration is an important pathological feature of osteoarthritis. The purpose of this study is to investigate whether the polarization-sensitive optical coherence tomography (PSOCT)-based optical polarization tractography (OPT) can be useful in imaging collagen structural changes in human osteoarthritic cartilage samples. OPT eliminated the banding artifacts in conventional PSOCT by calculating the depth-resolved local birefringence and fiber orientation. A close comparison between OPT and PSOCT showed that OPT provided improved visualization and characterization of the zonal structure in human cartilage...
December 2017: Journal of Biomedical Optics
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