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Osteoarthritis and light

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https://www.readbyqxmd.com/read/29286133/hydroxytyrosol-inhibits-the-inflammatory-response-of-osteoarthritis-chondrocytes-via-sirt6-mediated-autophagy
#1
Li-Qiang Zhi, Shu-Xin Yao, Hong-Liang Liu, Meng Li, Ning Duan, Jian-Bing Ma
Osteoarthritis (OA) is a common degenerative joint disease. Inflammation may exaggerate the catabolism and degeneration in the pathogenesis of OA. Hydroxytyrosol (HT) has been used in the management of inflammatory diseases. In addition, reports have revealed that autophagy was a therapeutic target of diseases caused by inflammation. Sirtuin 6 (SIRT6) has also been demonstrated to prevent OA development by reducing both the inflammatory response and chondrocyte senescence. However, the roles of SIRT6 and autophagy in cartilage and its underlying anti‑inflammatory mechanism are unknown...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29246142/association-between-metabolic-syndrome-and-knee-osteoarthritis-a-cross-sectional-study
#2
Dong-Xing Xie, Jie Wei, Chao Zeng, Tuo Yang, Hui Li, Yi-Lun Wang, Hui-Zhong Long, Zi-Ying Wu, Yu-Xuan Qian, Kang-Hua Li, Guang-Hua Lei
BACKGROUND: Osteoarthritis (OA) is the most prevalent chronic joint disease in China. The aim of this study was to examine the association between metabolic syndrome (MetS) and knee OA in a population-based Chinese study. METHODS: Data included in this analysis is from a cross-sectional study, i.e., the Xiangya Hospital Health Management Center Study. MetS was diagnosed according to the criteria defined by the Chinese Diabetes Society. Radiographic knee OA was defined as changes equivalent to Kellgren-Lawrence (K-L) grade 2 or above at least one side...
December 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29197177/parametric-imaging-of-collagen-structural-changes-in-human-osteoarthritic-cartilage-using-optical-polarization-tractography
#3
Mohammadreza Ravanfar, Ferris M Pfeiffer, Chantelle C Bozynski, Yuanbo Wang, Gang Yao
Collagen degeneration is an important pathological feature of osteoarthritis. The purpose of this study is to investigate whether the polarization-sensitive optical coherence tomography (PSOCT)-based optical polarization tractography (OPT) can be useful in imaging collagen structural changes in human osteoarthritic cartilage samples. OPT eliminated the banding artifacts in conventional PSOCT by calculating the depth-resolved local birefringence and fiber orientation. A close comparison between OPT and PSOCT showed that OPT provided improved visualization and characterization of the zonal structure in human cartilage...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29178861/contact-stresses-pressure-and-area-in-a-fixed-bearing-total-ankle-replacement-a-finite-element-analysis
#4
Nicolo Martinelli, Silvia Baretta, Jenny Pagano, Alberto Bianchi, Tomaso Villa, Gloria Casaroli, Fabio Galbusera
BACKGROUND: Mobile-bearing ankle implants with good clinical results continued to increase the popularity of total ankle arthroplasty to address endstage ankle osteoarthritis preserving joint movement. Alternative solutions used fixed-bearing designs, which increase stability and reduce the risk of bearing dislocation, but with a theoretical increase of contact stresses leading to a higher polyethylene wear. The purpose of this study was to investigate the contact stresses, pressure and area in the polyethylene component of a new total ankle replacement with a fixed-bearing design, using 3D finite element analysis...
November 25, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29128537/biomaterials-for-articular-cartilage-tissue-engineering-learning-from-biology
#5
REVIEW
A R Armiento, M J Stoddart, M Alini, D Eglin
Articular cartilage is commonly described as a tissue made of up to 80% water, devoid of blood vessels, nerves and lymphatics, and populated by only one cell type: at first glance, an easy tissue for clinicians to repair and for scientists to reproduce in a laboratory. Yet, chondral and osteochondral defects currently remain an open challenge in orthopedics and tissue engineering of the musculoskeletal system, without considering osteoarthritis. Why do we fail in repairing and regenerating articular cartilage? Behind its simple and homogenous appearance articular cartilage hides a heterogeneous composition, a high level of organisation and specific biomechanical properties that taken together make articular cartilage a unique material that we are not able yet to repair or reproduce with high fidelity...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29121327/short-acting-opioids-are-associated-with-comparable-analgesia-to-long-acting-opioids-in-patients-with-chronic-osteoarthritis-with-a-reduced-opioid-equivalence-dosing
#6
Ameer Ghodke, Stephanie Barquero, Paul R Chelminski, Timothy J Ives
Setting: There are no studies that exist within the primary care setting that address optimal opioid therapy in osteoarthritis patients. In light of the recently released US Centers for Disease Control and Prevention guidelines on opioid use in chronic noncancer pain, there is a pressing need to better characterize the effectiveness of long- and short-acting opioids. Objective: To examine the effectiveness of short-acting opioids (SAO) vs long-acting opioids (LAO) and combination therapies (SAO and LAO) for treating chronic osteoarthritis pain in a retrospective trial...
November 7, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29103557/relationship-of-knee-pain-to-time-in-moderate-and-light-physical-activities-data-from-osteoarthritis-initiative
#7
Jing Song, Alison H Chang, Rowland W Chang, Jungwha Lee, Daniel Pinto, Gillian Hawker, Michael Nevitt, Dorothy D Dunlop
INTRODUCTION: While OA literature indicates greater pain is related to less time being physically active, it is not known if time curtailment occurs primarily for moderate intensity activities or for light activities or in both. We examine the cross-sectional association of knee pain with physical activity using data from 1874 Osteoarthritis Initiative participants. METHODS: Knee pain characteristics of constant and intermittent pain were each scored by the Intermittent and Constant Osteoarthritis Pain instrument and categorized into four pain levels (no pain, intermittent pain below and above median level, and constant pain)...
October 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29079909/maximum-lifetime-body-mass-index-is-the-appropriate-predictor-of-knee-and-hip-osteoarthritis
#8
Sabine Patricia Singer, Dietmar Dammerer, Martin Krismer, Michael C Liebensteiner
INTRODUCTION: In light of inconsistencies in the literature, this study aimed to investigate the relationship between obesity (current and historic) and osteoarthritis (OA) of the knee or hip. MATERIALS AND METHODS: We examined 99 people (knee OA, hip OA and controls), age > 50 years, in a case-control study. The current weight, height and waist circumference were measured on site, and detailed weight changes over their lifetime were based on questionnaires and standardized interviews...
October 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29036332/sensitivity-to-physical-activity-predicts-daily-activity-among-pain-free-older-adults
#9
Leah Miller, Thomas Ohlman, Kelly Marie Naugle
Objective: Prior research indicates that older adults with knee osteoarthritis have increased sensitivity to physical activity (SPA) and respond to physical activities of stable intensity with increases in pain. Whether SPA is present in healthy older adults without chronic pain and predicts functional outcomes remains relatively unexplored. The purpose of this study was to determine the degree of SPA in healthy older adults in response to a standardized walking task, and whether SPA was associated with temporal summation of pain, pain-related fear of movement, and functional outcomes...
October 4, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29025005/correlation-of-pain-reduction-with-fmri-bold-response-in-osteoarthritis-patients-treated-with-paracetamol-randomized-double-blind-crossover-clinical-efficacy-study
#10
Yong Yue, Agron Collaku
Objective: To assess the relationship between the analgesic efficacy of extended-release paracetamol (ER-APAP) and brain blood oxygen level-dependent (BOLD) signal activation in response to painful stimulation measured by functional magnetic resonance imaging (fMRI) in patients with osteoarthritis of the knee. Methods: This placebo-controlled, double-blind, crossover, randomized trial (N = 25) comprised three treatment periods in which patients received four doses of an eight-hour ER-APAP caplet (2 x 665 mg), four doses of matched placebo, and no treatment...
August 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28987943/a-standardized-extract-of-butea-monosperma-lam-flowers-suppresses-the-il-1%C3%AE-induced-expression-of-il-6-and-matrix-metalloproteases-by-activating-autophagy-in-human-osteoarthritis-chondrocytes
#11
Mohammad Y Ansari, Nazir M Khan, Tariq M Haqqi
BACKGROUND/OBJECTIVE: Osteoarthritis (OA) is a leading cause of joint dysfunction, disability and poor quality of life in the affected population. The underlying mechanism of joint dysfunction involves increased oxidative stress, inflammation, high levels of cartilage extracellular matrix degrading proteases and decline in autophagy-a mechanism of cellular defense. There is no disease modifying therapies currently available for OA. Different parts of the Butea monosperma (Lam.) plant have widely been used in the traditional Indian Ayurvedic medicine system for the treatment of various human diseases including inflammatory conditions...
October 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28987643/blood-flow-restricted-resistance-training-in-older-adults-at-risk-of-mobility-limitations
#12
Summer B Cook, Dain P LaRoche, Michelle R Villa, Hannah Barile, Todd M Manini
High-load resistance training (HL) may be contraindicated in older adults due to pre-existing health conditions (e.g. osteoarthritis). Low-load blood flow restricted (BFR) resistance training offers an alternative to HL with potentially similar strength improvement. PURPOSE: To compare muscle strength, cross-sectional area (CSA), physical function, and quality of life (QOL) following 12-weeks of HL or BFR training in older adults at risk of mobility limitations. METHODS: Thirty-six males and females (mean: 75...
December 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28987080/review-of-literature-on-low-level-laser-therapy-benefits-for-nonpharmacological-pain-control-in-chronic-pain-and-osteoarthritis
#13
Robert Dima, Vinicius Tieppo Francio, Chris Towery, Saied Davani
Introduction • Low-level laser therapy (LLLT) is a form of light therapy that triggers biochemical changes within cells. Photons are absorbed by cellular photoreceptors, triggering chemical alterations and potential biochemical benefits to the human body. LLLT has been used in pain management for years and is also known as cold laser therapy, which uses low-frequency continuous laser of typically 600 to 1000 nm wavelength for pain reduction and healing stimulation. Many studies have demonstrated analgesic and anti-inflammatory effects provided by photobiomodulation in both experimental and clinical trials...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28975658/current-and-novel-injectable-hydrogels-to-treat-focal-chondral-lesions-properties-and-applicability
#14
REVIEW
Cecilia Pascual-Garrido, Francisco Rodriguez-Fontan, Elizabeth A Aisenbrey, Karin A Payne, Jorge Chahla, Laurie R Goodrich, Stephanie J Bryant
Focal chondral lesions and early osteoarthritis (OA) are responsible for progressive joint pain and disability in millions of people worldwide, yet there is currently no surgical joint preservation treatment available to fully restore the long term functionality of cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue...
October 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28934878/surgical-preparation-for-articular-cartilage-regeneration-in-the-osteoarthritic-knee-joint
#15
Joerg Mika, Thomas O Clanton, Catherine G Ambrose, Raimund W Kinne
PURPOSE: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. HYPOTHESIS: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. METHODS: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non-brute-force debridement for ACI...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#16
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
February 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28884332/subchondral-mesenchymal-stem-cells-from-osteoarthritic-knees-display-high-osteogenic-differentiation-capacity-through-microrna-29a-regulation-of-hdac4
#17
Wei-Shiung Lian, Ren-Wen Wu, Mel S Lee, Yu-Shan Chen, Yi-Chih Sun, Shing-Long Wu, Huei-Jing Ke, Jih-Yang Ko, Feng-Sheng Wang
Subchondral bone deterioration and osteophyte formation attributable to excessive mineralization are prominent features of end-stage knee osteoarthritis (OA). The cellular events underlying subchondral integrity diminishment remained elusive. This study was undertaken to characterize subchondral mesenchymal stem cells (SMSCs) isolated from patients with end-stage knee OA who required total knee arthroplasty. The SMSCs expressed surface antigens CD29, CD44, CD73, CD90, CD105, and CD166 and lacked CD31, CD45, and MHCII expression...
December 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28869091/potential-functional-benefit-from-light-intensity-physical-activity-in-knee-osteoarthritis
#18
Daniel K White, Jungwha Lee, Jing Song, Rowland W Chang, Dorothy Dunlop
INTRODUCTION: Knee pain may preclude participation in higher intensity physical activity in people with knee osteoarthritis and benefits of light activity are unclear. The effect of replacing sedentary time with light intensity activity on incident functional limitation 2 years later was investigated. METHODS: Included were people with or at high risk of knee osteoarthritis without baseline functional limitation using data from the Osteoarthritis Initiative collected between August 2008 and July 2010...
November 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28827187/epigenetics-in-osteoarthritis-potential-of-hdac-inhibitors-as-therapeutics
#19
REVIEW
Nazir M Khan, Tariq M Haqqi
Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory mechanisms for the molecular effectors of OA pathogenesis are poorly understood. Recent studies identified epigenetic events as a critical regulator of molecular players involved in the induction and development of OA. Epigenetic mechanisms include DNA methylation, non-coding RNA and histone modifications...
August 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28802215/predictors-of-self-reported-knee-osteoarthritis-in-community-dwelling-older-women-in-japan-a-cross-sectional-and-longitudinal-cohort-study
#20
Narumi Kojima, Miji Kim, Kyoko Saito, Yuko Yoshida, Hirohiko Hirano, Shuichi Obuchi, Hiroyuki Shimada, Takao Suzuki, Hunkyung Kim
PURPOSE: This study aimed to determine the predictors of knee osteoarthritis in community-dwelling elderly Japanese women. METHODS: In this prospective cohort study, The Tokyo Metropolitan Institute of Gerontology collected baseline data in 2008 and follow-up data in 2012 for participants from the Itabashi Ward of Tokyo, Japan. Participants were asked at each time point if they had been diagnosed with knee osteoarthritis. The baseline evaluation was conducted with 1289 community-dwelling women aged 75-85 years, of which 992 reported no history of knee osteoarthritis...
July 30, 2017: Archives of Gerontology and Geriatrics
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