keyword
MENU ▼
Read by QxMD icon Read
search

Osteoarthritis and light

keyword
https://www.readbyqxmd.com/read/28182736/comparison-of-clinical-and-radiological-outcomes-between-opening-wedge-and-closing-wedge-high-tibial-osteotomy-a-comprehensive-meta-analysis
#1
Lingfeng Wu, Jun Lin, Zhicheng Jin, Xiaobin Cai, Weiyang Gao
High tibial osteotomy (HTO) has been widely used for clinical treatment of osteoarthritis of the medial compartment of the knee, and both opening-wedge and closing-wedge HTO are the most commonly used methods. However, it remains unclear which technique has better clinical and radiological outcomes in practice. To systematically evaluate this issue, we conducted a comprehensive meta-analysis by pooling all available data for the opening-wedge HTO and closing-wedge HTO techniques from the electronic databases including PubMed, Embase, Wed of Science and Cochrane Library...
2017: PloS One
https://www.readbyqxmd.com/read/28148440/-the-pain-must-not-be-taken-lightly
#2
Claire Trochet
Michèle D. is aged 70 and has been suffering from osteoarthritis for many years. She describes her journey.
August 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/28087904/-protective-effect-of-diosgenin-on-chondrocytes-mediated-by-jak2-stat3-signaling-pathway-in-mice-with-osteoarthritis
#3
Jun Liu, Xiaole He, Ping Zhen, Shenghu Zhou, Xusheng Li
Objective: To investigate the effect of diosgenin (Dgn) on chondrocytes and its relation to JAK2/STAT3 signaling pathway in mice with osteoarthritis (OA).Methods: Fifteen male C57BL/6 mice were randomly divided into three groups:control group, OA group and OA+Dgn group. After 4 weeks of treatment, the histopathological changes of cartilage tissue were observed by toluidine blue staining under light microscopy and the ultrastructure of chondrocytes was observed under electron microscopy. The primarily cultured chondrocytes of OA mice were randomly divided into 4 groups:(1) OA group, (2) Dgn group, (3) Dgn+AG490 group, (4) AG490 group...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28078252/the-evaluation-of-the-effect-of-herbal-extract-on-osteoarthritis-in-vitro-and-in-vivo-study
#4
Jaeyong Kim, Siyoung Yang, Chul-Yung Choi
In this study, the anti-osteoarthritis effects of Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas extract (CPAE), observed and confirmed in previously clinical studies were further investigated by in vitro and in vivo studies. Anabolic biomarkers related to healthy cartilage maintenance, such as aggrecan, type II collagen α-1 (Col2a1), sex determining region Y-box-9 (Sox-9), and catabolic biomarkers related to osteoarthritis, such as cyclooxygenase-2 (Cox-2), matrix metalloproteinase-13 (Mmp13), and nuclear factor kappa-light-chain-enhancer of activated B cells (Nfκb), were evaluated by quantitative reverse transcriptase polymerase chain reaction and reporter gene assay...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28029748/physical-activity-minimum-threshold-predicting-improved-function-in-adults-with-lower-limb-symptoms
#5
Dorothy D Dunlop, Jing Song, Jungwha Lee, Abigail L Gilbert, Pamela A Semanik, Linda Ehrlich-Jones, Christine A Pellegrini, Daniel Pinto, Barbara Ainsworth, Rowland W Chang
OBJECTIVES: The objective is to identify an evidence-based minimum physical activity threshold to predict improved or sustained high function for adults with lower limb joint symptoms. METHODS: Prospective multi-site data from 1629 adults aged 49 years or older with symptomatic lower limb joint pain/aching/stiffness participating in Osteoarthritis Initiative accelerometer monitoring substudy were clinically assessed two years apart. Improved/high function in 2-year gait speed and patient-reported outcomes (PRO) were based on improving or remaining in the best (i...
December 28, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/28000846/reduced-mir%C3%A2-26a-and-mir%C3%A2-26b-expression-contributes-to-the-pathogenesis-of-osteoarthritis-via-the-promotion-of-p65-translocation
#6
Xuefeng Yin, Jiang-Quan Wang, Shu-Yi Yan
Osteoarthritis (OA) is a common chronic joint disease, the etiology of which is complex. Disturbance to proinflammatory and anti‑inflammatory signaling pathways is a major cause of OA. MicroRNAs (miRNAs/miR) are a group of endogenous, short, non‑coding RNAs, the expression profile of which is disturbed in the cartilage of patients with OA. To determine the function of miRNAs during the progression of OA, the present study detected the expression levels of nine candidate miRNAs in cartilage samples from 33 patients with OA...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27965139/physiological-exercise-loading-suppresses-post-traumatic-osteoarthritis-progression-via-an-increase-in-bone-morphogenetic-proteins-expression-in-an-experimental-rat-knee-model
#7
H Iijima, A Ito, M Nagai, J Tajino, S Yamaguchi, W Kiyan, A Nakahata, J Zhang, T Wang, T Aoyama, K Nishitani, H Kuroki
OBJECTIVE: To evaluate the dose-response relationship of exercise loading in the cartilage-subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the knee. DESIGN: Destabilized medial meniscus (DMM) surgery was performed on the right knee of 12-week-old male Wistar rats, and sham surgery was performed on the contralateral knee. Four weeks after the surgery, the animals were subjected to moderate (12 m/min) or intense (21 m/min) treadmill exercises for 30 min/day, 5 days/week for 4 weeks...
December 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27890430/tar-dna-binding-protein-43-inhibits-inflammatory-response-and-protects-chondrocyte-function-by-modulating-rack1-expression-in-osteoarthritis
#8
Yongming Huang, Qiming Huang, Haitao Su, Xiujun Mai, Enhui Feng, Zhenwu Cao, Xiuyun Zeng
BACKGROUND: TAR DNA-binding protein-43 (TDP-43, transactive response DNA binding protein 43kDa) accumulates in the cytoplasm of affected neurons and glia, as large inclusions of stress granules (SGs). However, the mechanism of TDP-43 interaction with the target genes and its specific role in osteoarthritis (OA) progression is still unknown. The goal of this study was to identify the role of TDP-43 in OA progression by modulating its target genes. METHODS: MSCs were transfected with TDP-43 gene lentivirus...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27845712/the-role-of-mirnas-in-common-inflammatory-arthropathies-osteoarthritis-and-gouty-arthritis
#9
REVIEW
Panagiota Papanagnou, Theodora Stivarou, Maria Tsironi
MicroRNAs (miRNAs) are small, non-coding RNA species that are highly evolutionarily conserved, from higher invertebrates to man. Up to 1000 miRNAs have been identified in human cells thus far, where they are key regulators of the expression of numerous targets at the post-transcriptional level. They are implicated in various processes, including cell differentiation, metabolism, and inflammation. An expanding list of miRNAs is known to be involved in the pathogenesis of common, non-autoimmune inflammatory diseases...
November 11, 2016: Biomolecules
https://www.readbyqxmd.com/read/27820852/osteoarthritis-in-the-knee-joints-of-g%C3%A3-ttingen-minipigs-after-resection-of-the-anterior-cruciate-ligament-missing-correlation-of-mri-gene-and-protein-expression-with-histological-scoring
#10
Gregor Reisig, Michael Kreinest, Wiltrud Richter, Mechthild Wagner-Ecker, Dietmar Dinter, Ulrike Attenberger, Barbara Schneider-Wald, Stefan Fickert, Markus L Schwarz
INTRODUCTION: The Göttingen Minipig (GM) is used as large animal model in articular cartilage research. The aim of the study was to introduce osteoarthritis (OA) in the GM by resecting the anterior cruciate ligament (ACLR) according to Pond and Nuki, verified by histological and magnetic resonance imaging (MRI) scoring as well as analysis of gene and protein expression. MATERIALS AND METHODS: The eight included skeletally mature female GM were assessed after ACLR in the left and a sham operation in the right knee, which served as control...
2016: PloS One
https://www.readbyqxmd.com/read/27808445/chemokines-and-inflammation-in-osteoarthritis-insights-from-patients-and-animal-models
#11
REVIEW
Carla R Scanzello
Evidence has been building that the pathologic drive for development of osteoarthritis (OA) involves more than simple mechanical "wear and tear." Inflammatory mechanisms play an important role in the tissue response to joint injury, and are involved in development of post-traumatic OA. Inflammation also appears integral to the progression of OA, whether post-traumatic or spontaneous, contributing to the evolution of joint tissue degradation and remodeling as well as joint pain. Both patient-based studies and in vivo models of disease have shed light on a number of inflammatory pathways and mediators that impact various aspects of this disease, both structurally and symptomatically...
November 3, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27727249/microrna-140-inhibits-inflammation-and-stimulates-chondrogenesis-in-a-model-of-interleukin-1%C3%AE-induced-osteoarthritis
#12
Tommy A Karlsen, Gustavo Antonio de Souza, Bjørn Ødegaard, Lars Engebretsen, Jan E Brinchmann
Osteoarthritis is a serious disease of articular cartilage. The pathogenic factors contributing to this disorder are inflammation, extracellular matrix degradation and failure to rebuild the articular cartilage. Preclinical studies suggest that microRNA-140 may play a protective role in osteoarthritis development, but little is known about the mechanism by which this occurs. Here we present the results of forced expression of microRNA-140 in an in vitro model of osteoarthritis, evaluated by global proteomics analysis...
October 11, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27727159/preparation-of-low-molecular-weight-chondroitin-sulfates-screening-of-a-high-anti-complement-capacity-of-low-molecular-weight-chondroitin-sulfate-and-its-biological-activity-studies-in-attenuating-osteoarthritis
#13
Lian Li, Yan Li, Danyang Feng, Linghua Xu, Fengxin Yin, Hengchang Zang, Chunhui Liu, Fengshan Wang
Chondroitin sulfate (CS) plays important roles in the complement system. However, the CS structure is complicated due to different sources and the number and positions of sulfate groups. The objective of this study was to prepare different low molecular weight chondroitin sulfates (LMWCSs) and to investigate the biological activity in anti-complement capacity. A series of LMWCSs was prepared from different sources and characterized by ultraviolet-visible (UV) spectroscopy, high-performance liquid chromatography (HPLC), size exclusion chromatography-multiangle laser light scattering (SEC-MALLS) and nuclear magnetic resonance (NMR) spectroscopy...
October 11, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27703331/the-spice-for-joint-inflammation-anti-inflammatory-role-of-curcumin-in-treating-osteoarthritis
#14
REVIEW
Kok-Yong Chin
Osteoarthritis is a degenerative disease of the joint affecting aging populations worldwide. It has an underlying inflammatory cause, which contributes to the loss of chondrocytes, leading to diminished cartilage layer at the affected joints. Compounds with anti-inflammatory properties are potential treatment agents for osteoarthritis. Curcumin derived from Curcuma species is an anti-inflammatory compound as such. This review aims to summarize the antiosteoarthritic effects of curcumin derived from clinical and preclinical studies...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27671326/hip-osteoarthritis-etiopathogenesis-and-implications-for-management
#15
REVIEW
Nicholas J Murphy, Jillian P Eyles, David J Hunter
Highly prevalent among the elderly, hip osteoarthritis (OA) carries a heavy burden of disease. Guidelines for the management of hip OA are often extrapolated from knee OA research, despite clear differences in the etiopathogenesis and response to treatments of OA at these sites. We propose that hip OA requires specific attention separate from other OA phenotypes. Our understanding of the etiopathogenesis of hip OA has seen significant advance over the last 15 years, since Ganz and colleagues proposed femoroacetabular impingement (FAI) as an important etiological factor...
November 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27667531/are-midterm-patient-reported-outcome-measures-between-rotating-platform-mobile-bearing-prosthesis-and-medial-pivot-prosthesis-different-a-minimum-of-5-year-follow-up-study
#16
Nam Y Choi, Yong In, Jae-Ho Bae, Jung-Hoon Do, Seung J Chung, In J Koh
BACKGROUND: Both rotating-platform (RP) mobile-bearing and medial-pivot (MP) fixed-bearing prostheses allow axial femorotibial rotation using a highly conforming polyethylene insert. However, limited comparative data are available between the 2 designs. This study was performed to compare the midterm clinical outcomes and patient-reported outcome measures (PROMs) of RP and MP prostheses. METHODS: We retrospectively reviewed the records of 52 total knee arthroplasties using RP mobile-bearing prosthesis and 49 total knee arthroplasties using MP fixed prosthesis with a minimum follow-up period of 5 years...
August 31, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27660935/detection-of-calcium-crystals-in-knee-osteoarthritis-synovial-fluid-a-comparison-between-polarized-light-and-scanning-electron-microscopy
#17
Paola Frallonardo, Francesca Oliviero, Luca Peruzzo, Leonardo Tauro, Anna Scanu, Paola Galozzi, Roberta Ramonda, Leonardo Punzi
BACKGROUND: The identification of calcium crystals in synovial fluid (SF) of patients with osteoarthritis (OA) represents an important step in understanding the role of these crystals in synovial inflammation and disease progression. OBJECTIVES: This study aimed to investigate the presence of calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals in SF collected from patients with symptomatic knee OA by scanning electron microscopy (SEM) coupled to x-ray energy dispersive spectroscopy, compensated polarized light microscopy (CPLM), and alizarin red staining...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27633696/-the-pain-must-not-be-taken-lightly
#18
Claire Trochet
Michèle D. is aged 70 and has been suffering from osteoarthritis for many years. She describes her journey.
August 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/27614684/ambient-light-based-optical-biosensing-platform-with-smartphone-embedded-illumination-sensor
#19
Yoo Min Park, Yong Duk Han, Hyeong Jin Chun, Hyun C Yoon
We present a hand-held optical biosensing system utilizing a smartphone-embedded illumination sensor that is integrated with immunoblotting assay method. The smartphone-embedded illumination sensor is regarded as an alternative optical receiver that can replaces the conventional optical analysis apparatus because the illumination sensor can respond to the ambient light in a wide range of wavelengths, including visible and infrared. To demonstrate the biosensing applicability of our system employing the enzyme-mediated immunoblotting and accompanying light interference, various types of ambient light conditions including outdoor sunlight and indoor fluorescent were tested...
September 2, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27499316/is-there-crosstalk-between-subchondral-bone-cartilage-and-meniscus-in-the-pathogenesis-of-osteoarthritis
#20
O Şahap Atik, Deniz Erdoğan, Cemile Merve Seymen, Hasan Hüseyin Bozkurt, Gülnur Take Kaplanoğlu
OBJECTIVES: This study aims to investigate if there is any crosstalk between subchondral bone, cartilage, and meniscus in the pathogenesis of osteoarthritis. PATIENTS AND METHODS: Twelve female patients (mean age 64 years; range 59 to 71 years) with osteoarthritis in medial compartment were included in the study. The samples of subchondral bone, cartilage and meniscus were obtained during total knee arthroplasty. Degenerated tissue samples obtained from medial compartment were used as the experimental group (12 samples of subchondral bone and cartilage, 1x1 cm each; and 12 samples of meniscus, 1x1 cm each)...
August 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
keyword
keyword
82825
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"