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https://www.readbyqxmd.com/read/28934878/surgical-preparation-for-articular-cartilage-regeneration-in-the-osteoarthritic-knee-joint
#1
Joerg Mika, Thomas O Clanton, Catherine G Ambrose, Raimund W Kinne
PURPOSE: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. HYPOTHESIS: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. METHODS: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non-brute-force debridement for ACI...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#2
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28884332/subchondral-mesenchymal-stem-cells-from-osteoarthritic-knees-display-high-osteogenic-differentiation-capacity-through-microrna-29a-regulation-of-hdac4
#3
Wei-Shiung Lian, Ren-Wen Wu, Mel S Lee, Yu-Shan Chen, Yi-Chih Sun, Shing-Long Wu, Huei-Jing Ke, Jih-Yang Ko, Feng-Sheng Wang
Subchondral bone deterioration and osteophyte formation attributable to excessive mineralization are prominent features of end-stage knee osteoarthritis (OA). The cellular events underlying subchondral integrity diminishment remained elusive. This study was undertaken to characterize subchondral mesenchymal stem cells (SMSCs) isolated from patients with end-stage knee OA who required total knee arthroplasty. The SMSCs expressed surface antigens CD29, CD44, CD73, CD90, CD105, and CD166 and lacked CD31, CD45, and MHCII expression...
September 7, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28869091/potential-functional-benefit-from-light-intensity-physical-activity-in-knee-osteoarthritis
#4
Daniel K White, Jungwha Lee, Jing Song, Rowland W Chang, Dorothy Dunlop
INTRODUCTION: Knee pain may preclude participation in higher intensity physical activity in people with knee osteoarthritis and benefits of light activity are unclear. The effect of replacing sedentary time with light intensity activity on incident functional limitation 2 years later was investigated. METHODS: Included were people with or at high risk of knee osteoarthritis without baseline functional limitation using data from the Osteoarthritis Initiative collected between August 2008 and July 2010...
August 28, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28827187/epigenetics-in-osteoarthritis-potential-of-hdac-inhibitors-as-therapeutics
#5
REVIEW
Nazir M Khan, Tariq M Haqqi
Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory mechanisms for the molecular effectors of OA pathogenesis are poorly understood. Recent studies identified epigenetic events as a critical regulator of molecular players involved in the induction and development of OA. Epigenetic mechanisms include DNA methylation, non-coding RNA and histone modifications...
August 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28802215/predictors-of-self-reported-knee-osteoarthritis-in-community-dwelling-older-women-in-japan-a-cross-sectional-and-longitudinal-cohort-study
#6
Narumi Kojima, Miji Kim, Kyoko Saito, Yuko Yoshida, Hirohiko Hirano, Shuichi Obuchi, Hiroyuki Shimada, Takao Suzuki, Hunkyung Kim
PURPOSE: This study aimed to determine the predictors of knee osteoarthritis in community-dwelling elderly Japanese women. METHODS: In this prospective cohort study, The Tokyo Metropolitan Institute of Gerontology collected baseline data in 2008 and follow-up data in 2012 for participants from the Itabashi Ward of Tokyo, Japan. Participants were asked at each time point if they had been diagnosed with knee osteoarthritis. The baseline evaluation was conducted with 1289 community-dwelling women aged 75-85 years, of which 992 reported no history of knee osteoarthritis...
July 30, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28800775/lack-of-high-bmi-related-features-in-adipocytes-and-inflammatory-cells-in-the-infrapatellar-fat-pad-ifp
#7
Anja J de Jong, Inge R Klein-Wieringa, Stefan N Andersen, Joanneke C Kwekkeboom, Linda Herb-van Toorn, Badelog J E de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J L van der Heide, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch, Annemarie M Zuurmond, Vedrana Stojanovic-Susulic, Rob G H H Nelissen, René E M Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
BACKGROUND: Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and molecular body mass index (BMI)-related features in the IFP of OA patients. METHODS: Patients with knee OA (N = 155, 68% women, mean age 65 years, mean (SD) BMI 29...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28768536/a-novel-composite-formulation-of-palmitoylethanolamide-and-quercetin-decreases-inflammation-and-relieves-pain-in-inflammatory-and-osteoarthritic-pain-models
#8
Domenico Britti, Rosalia Crupi, Daniela Impellizzeri, Enrico Gugliandolo, Roberta Fusco, Carlo Schievano, Valeria Maria Morittu, Maurizio Evangelista, Rosanna Di Paola, Salvatore Cuzzocrea
BACKGROUND: Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function. Currently, non-steroidal anti-inflammatory drugs (e.g., meloxicam) are the cornerstone of treatment for OA pain, but side effects with long-term use pose important challenges to veterinary practitioners when dealing with OA pain. Palmitoylethanolamide (PEA) is a naturally-occurring fatty acid amide, locally produced on demand by tissues in response to stress...
August 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28760147/the-2016-high-heels-health-effects-and-psychosexual-benefits-high-habits-study-systematic-review-of-reviews-and-additional-primary-studies
#9
Max Barnish, Heather May Morgan, Jean Barnish
BACKGROUND: High-heeled shoes (high heels) are frequently worn by many women and form an important part of female gender identity. Issues of explicit and implicit compulsion to wear high heels have been noted. Previous studies and reviews have provided evidence that high heels are detrimental to health. However, the evidence base remains fragmented and no review has covered both the epidemiological and biomechanical literature. In addition, no review has considered the psychosexual benefits that offer essential context in understanding the public health challenge of high heels...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28752186/low-impact-sports-activities-are-feasible-after-meniscus-transplantation-a-systematic-review
#10
REVIEW
Sue D Barber-Westin, Frank R Noyes
PURPOSE: To determine sports activities achieved after meniscus transplantation and if associations exist between sports activity levels and transplant failure or progression of tibiofemoral osteoarthritis (OA). METHODS: A systematic search was performed using PubMed and Cochrane online databases. Inclusionary criteria were English language, clinical trials published from 1996 through May 2017, minimum 2 years of follow-up, and sports activity data reported. RESULTS: Twenty-eight studies were included in which 1521 menisci were implanted into 1497 patients...
July 27, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28728820/role-of-piezo-channels-in-joint-health-and-injury
#11
W Lee, F Guilak, W Liedtke
Cartilage is an intrinsically mechanically sensitive tissue composed of chondrocytes as the only cell type. Chondrocyte mechanotransduction is not well understood, but recently we identified critical components of the mechanotransduction machinery demonstrating how mechanical stimulation of these cells can be converted into cellular calcium signals. Physiologic mechanical cues induce anabolic responses of (post-mitotic) chondrocytes via transient receptor potential vanilloid 4 ion channels, whereas injurious mechanical stress is transduced by Piezo1 jointly with Piezo2 ion channels...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28713485/micrornas-and-autophagy-fine-players-in-the-control-of-chondrocyte-homeostatic-activities-in-osteoarthritis
#12
REVIEW
Stefania D'Adamo, Silvia Cetrullo, Manuela Minguzzi, Ylenia Silvestri, Rosa Maria Borzì, Flavio Flamigni
Osteoarthritis (OA) is a debilitating degenerative disease of the articular cartilage with a multifactorial etiology. Aging, the main risk factor for OA development, is associated with a systemic oxidative and inflammatory phenotype. Autophagy is a central housekeeping system that plays an antiaging role by supporting the clearance of senescence-associated alterations of macromolecules and organelles. Autophagy deficiency has been related to OA pathogenesis because of the accumulation of cellular defects in chondrocytes...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28696795/decoy-receptor-3-down-regulates-centrosomal-protein-70%C3%A2-kda-specifically-in-rheumatoid-synovial-fibroblasts
#13
Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Ryosuke Kuroda
OBJECTIVES: Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby preventing their effects. Using a microarray assay, we previously newly identified centrosomal protein 70 kDa (CEP70) as one of the genes whose expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS) is reduced by DcR3...
July 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28669720/ultra-low-friction-between-boundary-layers-of-hyaluronan-phosphatidylcholine-complexes
#14
Linyi Zhu, Jasmine Seror, Anthony J Day, Nir Kampf, Jacob Klein
The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfaces bearing attached hyaluronan (hyaluronic acid, or HA) to which different phosphatidylcholine (PC) lipids had been added, in the form of small unilamellar vesicles (SUVs or liposomes), using a surface force balance, to shed light on possible cartilage boundary lubrication by such complexes...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28669597/local-intra-articular-injection-of-resveratrol-delays-cartilage-degeneration-in-c57bl-6-mice-by-inducing-autophagy-via-ampk-mtor-pathway
#15
Na Qin, Liwei Wei, Wuyin Li, Wei Yang, Litao Cai, Zhuang Qian, Shufang Wu
Autophagy is an essential cellular homeostasis mechanism that was found to be compromised in aging and osteoarthritis (OA) cartilage. Previous studies showed that resveratrol can effectively regulate autophagy in other cells. The purpose of this study was to determine whether the chondroprotective effect of resveratrol was related to chondrocyte autophagy and to elucidate underlying mechanisms. OA model was induced by destabilization of the medial meniscus (DMM) in 10-week-old male mice. OA mice were treated with resveratrol with/without 3-MA for 8 weeks beginning 4 weeks after surgery...
June 15, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28654765/a-traffic-light-grading-system-of-hip-dysplasia-to-predict-the-success-of-arthroscopic-hip-surgery
#16
George Grammatopoulos, Owain L I Davies, Ahmed El-Bakoury, Harinderjit S Gill, Tom C B Pollard, Antonio J Andrade
BACKGROUND: The role of hip arthroscopic surgery in dysplasia is controversial. PURPOSE: To determine the 7-year joint preservation rate after hip arthroscopic surgery in hip dysplasia and identify anatomic and intraoperative features that predict the success of hip preservation with arthroscopic surgery, allowing the formulation of an evidence-based classification system. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Between 2008 and 2013, 111 hips with dysplastic features (acetabular index [AI] >10° and/or lateral center-edge angle [LCEA] <25°) that underwent arthroscopic surgery were identified...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28653869/an-8-week-neuromuscular-exercise-program-for-patients-with-mild-to-moderate-knee-osteoarthritis-a-case-series-drawn-from-a-registered-clinical-trial
#17
Brian Clausen, Anders Holsgaard-Larsen, Ewa M Roos
OBJECTIVE:   To describe the feasibility of a neuromuscular exercise (NEMEX) program in patients with mild to moderate knee osteoarthritis (KOA). BACKGROUND:   Neuromuscular exercise has been increasingly used in patients with osteoarthritis to achieve sensorimotor control and improved daily function. TREATMENT:   A study of the first 23 physically active patients (11 men, 12 women; age range = 48-70 years) who had mild to moderate KOA and were undergoing an 8-week, twice-weekly program, consisting of 11 exercises with 3 to 4 levels of difficulty, as part of an ongoing randomized controlled trial...
June 2, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28628801/evaluation-of-midcarpal-capitate-contact-mechanics-in-normal-injured-and-post-operative-wrists
#18
Saman Modaresi, Madhan S Kallem, Phil Lee, Terence E McIff, E Bruce Toby, Kenneth J Fischer
BACKGROUND: Scapholunate ligament injury is a commonly occurring carpal ligament injury. Pathology associated with scapholunate ligament injury depends on several factors such as the time after injury, type of injury (instability) and the development of osteoarthritis. The aim of this study was to investigate and compare contact mechanics in the lunocapitate and scaphocapitate joints in the normal, injured (scapholunate dissociation) and repaired (postoperative) wrist. METHODS: Four human subjects with scapholunate ligament dissociation participated in this study...
August 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28620193/microrna-29a-counteracts-synovitis-in-knee-osteoarthritis-pathogenesis-by-targeting-vegf
#19
Jih-Yang Ko, Mel S Lee, Wei-Shiung Lian, Wen-Tsan Weng, Yi-Chih Sun, Yu-Shan Chen, Feng-Sheng Wang
Synovitis contributes to the development of osteoarthritis (OA) of the knee. MicroRNAs regulate joint microenvironment homeostasis and deterioration. This study was undertaken to characterize the actions of microRNA-29a (miR-29a) to synovial remodeling in OA joints. Synovial specimens isolated from patients with end-stage OA knees showed abundant fibrotic matrix and vessel histopathology concomitant with weak miR-29a expression. In vitro, miR-29a knockdown caused synovial fibroblasts to exhibit high expressions of collagen III, TGF-β1, MMP9, MMP13, and ADAMTS5, whereas miR-29a overexpression diminished these joint-deleterious factors...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28595566/a-systemic-review-of-the-sources-of-adult-mesenchymal-stem-cells-and-their-suitability-in-musculoskeletal-applications
#20
Rhiannon Nancarrow-Lei, Pouya Mafi, Reza Mafi, Wasim Khan
Background: Adult mesenchymal stem cells (MSCs) were first isolated from bone marrow by Friedenstein in 1976. These cells were clonogenic, non-haematopoietic, and able to replicate extensively in vitro. The fields of regenerative medicine and tissue engineering have grown dramatically since their inception. In the decades since, MSCs have been identified from mesoderm-, endoderm- and ectoderm-derived tissues. In light of our ageing population, the need for effective cell-based therapies for tissue repair and regeneration is ever-expanding...
June 8, 2017: Current Stem Cell Research & Therapy
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