keyword
MENU ▼
Read by QxMD icon Read
search

Vagina and (biomechanical or mechanical or tensile)

keyword
https://www.readbyqxmd.com/read/28062423/prominent-metalware-from-pelvic-surgery-causing-dyspareunia
#1
Mithun Nambiar, Samuel Raymond Heaton, Andrew John Stevenson, Andrew Thomas Bucknill
We present a case of female dyspareunia secondary to metalware placement during extensive pelvic surgery following a motor vehicle accident. The patient initially had an uneventful recovery from her operations. However, she noticed pain with vaginal intercourse, due to a screw tip which was palpable on vaginal examination. X-ray imaging confirmed long screws in the medial part of an anterior column plate, which were impacting on the anterior vaginal wall. Subsequent percutaneous removal of two screws resulted in resolution of her symptoms of painful vaginal intercourse...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28061432/identification-and-functional-analysis-of-a-novel-lhx1-mutation-associated-with-congenital-absence-of-the-uterus-and-vagina
#2
Wei Zhang, Xueya Zhou, Liyang Liu, Ying Zhu, Chunmei Liu, Hong Pan, Qiong Xing, Jing Wang, Xi Wang, Xuegong Zhang, Yunxia Cao, Binbin Wang
Congenital absence of the uterus and vagina (CAUV) is the most extreme female Müllerian duct abnormality. Several researches proposed that genetic factors contributed to this disorder, whereas the precise genetic mechanism is far from full elucidation. Here, utilizing whole-exome sequencing (WES), we identified one novel missense mutation in LHX1 (NM_005568: c.G1108A, p.A370T) in one of ten unrelated patients diagnosed with CAUV. This mutation was absent from public databases and our internal database. Through the luciferase reporter analysis, we found that the mutation could change the transcriptional activity of LHX1 and its effect on the regulation of the downstream target gene GSC, which might be associated with urogenital system development...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28052314/elevated-nitric-oxide-in-recurrent-vulvovaginal-candidiasis-association-to-clinical-findings
#3
Cathrin Alvendal, Sophia Ehrström, Annelie Brauner, Jon O Lundberg, Nina Bohm-Starke
INTRODUCTION: Recurrent vulvovaginal candidiasis (RVVC) is defined as 3-4 episodes per year and causes substantial suffering. Little is known about the mechanisms leading to relapses in otherwise healthy women. Nitric oxide (NO) is part of the non-specific host defense and is increased during inflammation. NO levels were measured and the expression of inducible nitric oxide synthase (iNOS) was analyzed in the vagina during an acute episode of RVVC and after treatment with fluconazole...
January 4, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28051087/effects-of-depot-medroxyprogesterone-acetate-on-the-immune-microenvironment-of-the-human-cervix-and-endometrium-implications-for-hiv-susceptibility
#4
K K Smith-McCune, J F Hilton, U Shanmugasundaram, J W Critchfield, R M Greenblatt, D Seidman, S Averbach, L C Giudice, B L Shacklett
Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28035443/effect-of-mesh-width-on-apical-support-after-sacrocolpopexy
#5
Sunil Balgobin, Joseph L Fitzwater, Donald D McIntire, Imelda J Delgado, Clifford Y Wai
INTRODUCTION AND HYPOTHESIS: We evaluated the effect of polypropylene mesh width on vaginal apical support, mesh elongation, and mesh tensile strength for abdominal sacrocolpopexy. METHODS: Abdominal sacrocolpopexy was performed on ten cadavers using pieces of polypropylene mesh of width 1, 2, and 3 cm. Weights of 1, 2, 3, and 4 kg were sequentially applied to the vagina. The total distance moved by the vaginal apex, and the amount of stretch of the intervening mesh segment between the sacrum and the vagina were recorded for each width...
December 29, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/28008866/antiviral-potential-and-mode-of-action-of-indigofera-heterantha-against-hsv-2-by-targeting-the-early-stages-of-infection
#6
Natasha Kapoor Kaushik, Rupa Guha, Becky M Thomas
BACKGROUND: The development of antivirals against herpes simplex virus 2 (HSV-2) has a major public health importance because of the wide spectrum of associated clinical disease in both immunocompetent and immunocompromised populations. Even with the extensive use of acyclovir, issues such as emergence of drug resistant strains, poor oral bioavailability, and low effectiveness in recurrent infections have highlighted the requirement for alternate therapies. Plants, which are rich in metabolites and active against viruses, are being explored as one such source...
December 23, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/28008325/lactobacilli-dominance-and-vaginal-ph-why-is-the-human-vaginal-microbiome-unique
#7
Elizabeth A Miller, DeAnna E Beasley, Robert R Dunn, Elizabeth A Archie
The human vaginal microbiome is dominated by bacteria from the genus Lactobacillus, which create an acidic environment thought to protect women against sexually transmitted pathogens and opportunistic infections. Strikingly, lactobacilli dominance appears to be unique to humans; while the relative abundance of lactobacilli in the human vagina is typically >70%, in other mammals lactobacilli rarely comprise more than 1% of vaginal microbiota. Several hypotheses have been proposed to explain humans' unique vaginal microbiota, including humans' distinct reproductive physiology, high risk of STDs, and high risk of microbial complications linked to pregnancy and birth...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27981794/reproductive-tract-histology-in-south-american-fur-seal-pups-arctophoca-australis
#8
Helena Katz, Olle Johansson
In the present study, a detailed histological description of the female reproductive tract of South American fur seal (Arctophoca australis) pups has been conducted. The uterine tube was covered by cuboidal to columnar epithelium; nerve fibers were present in the mesosalpinx and beneath the muscular layer. The uterus was bipartitus; the endometrial surface of the horns was lined by a simple cuboidal or columnar epithelium with deep tubular glands; caudally ("the transition area"), the epithelium changed to pseudostratified columnar, few tubular glands were present and the myometrium increased in width...
December 16, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27981257/assessing-the-efficacy-of-vaginal-hyoscine-butyl-bromide-on-cervical-ripening-prior-to-intrauterine-procedures-a-double-blinded-clinical-trial
#9
Shiva Hadadian, Masoumeh Fallahian
BACKGROUND: Unripe cervix prevents entering the endometrial cavity during intrauterine procedures. Mechanical dilatation of cervical canal might cause undesirable complications. OBJECTIVE: To investigate the substitute of mechanical intervention with chemical treatment by administering hyoscine to patients. MATERIALS AND METHODS: Sixty non-pregnant women, 20-70 years of age, with a closed cervix who were scheduled for an intrauterine procedure, were randomly divided into two groups...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27931152/planting-the-seed-origins-composition-and-postnatal-health-significance-of-the-fetal-gastrointestinal-microbiota
#10
Lisa F Stinson, Matthew S Payne, Jeffrey A Keelan
It has long been assumed that establishment of the fetal microbiome commences with the birthing process. However, recent studies have found bacterial DNA in umbilical cord blood, placenta, amniotic fluid, meconium, and fetal membranes in healthy normal pregnancies, leading to suggestions that the seeding of the fetal microbiome may commence in utero long before delivery. The origins of the microbiota of the fetal gastrointestinal (GI) tract have not yet been conclusively determined, although bacterial translocation from the maternal circulation, or ascension from the vagina, are both likely to be contributing pathways...
December 8, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27919079/receptor-usage-dictates-hiv-1-restriction-by-human-trim5%C3%AE-in-dendritic-cell-subsets
#11
Carla M S Ribeiro, Ramin Sarrami-Forooshani, Laurentia C Setiawan, Esther M Zijlstra-Willems, John L van Hamme, Wikky Tigchelaar, Nicole N van der Wel, Neeltje A Kootstra, Sonja I Gringhuis, Teunis B H Geijtenbeek
The most prevalent route of HIV-1 infection is across mucosal tissues after sexual contact. Langerhans cells (LCs) belong to the subset of dendritic cells (DCs) that line the mucosal epithelia of vagina and foreskin and have the ability to sense and induce immunity to invading pathogens. Anatomical and functional characteristics make LCs one of the primary targets of HIV-1 infection. Notably, LCs form a protective barrier against HIV-1 infection and transmission. LCs restrict HIV-1 infection through the capture of HIV-1 by the C-type lectin receptor Langerin and subsequent internalization into Birbeck granules...
December 15, 2016: Nature
https://www.readbyqxmd.com/read/27914563/differential-effects-of-testosterone-and-estradiol-on-clitoral-function-an-experimental-study-in-rats
#12
Paolo Comeglio, Ilaria Cellai, Sandra Filippi, Chiara Corno, Francesca Corcetto, Annamaria Morelli, Elena Maneschi, Elisa Maseroli, Edoardo Mannucci, Massimiliano Fambrini, Mario Maggi, Linda Vignozzi
INTRODUCTION: Female sexual response is a complex phenomenon in which psychological, neurologic, and vascular mechanisms and hormonal factors interact. During the arousal phase, they cooperate to increase genital blood flow, thus inducing engorgement of the clitoris and lubrication of the vagina. Regulation of vascular and non-vascular smooth muscle tone is the crucial event in the erectile process. Preclinical studies have suggested that nitric oxide (NO) is the main vasodilator neurotransmitter modulating, through the second messenger cyclic guanosine monophosphate (cGMP), clitoral flow vessels...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27898732/chemokine-levels-in-the-penile-coronal-sulcus-correlate-with-hiv-1-acquisition-and-are-reduced-by-male-circumcision-in-rakai-uganda
#13
Jessica L Prodger, Ronald H Gray, Brett Shannon, Kamnoosh Shahabi, Xiangrong Kong, Kate Grabowski, Godfrey Kigozi, Fred Nalugoda, David Serwadda, Maria J Wawer, Steven J Reynolds, Cindy M Liu, Aaron A R Tobian, Rupert Kaul
Individual susceptibility to HIV is heterogeneous, but the biological mechanisms explaining differences are incompletely understood. We hypothesized that penile inflammation may increase HIV susceptibility in men by recruiting permissive CD4 T cells, and that male circumcision may decrease HIV susceptibility in part by reducing genital inflammation. We used multi-array technology to measure levels of seven cytokines in coronal sulcus (penile) swabs collected longitudinally from initially uncircumcised men enrolled in a randomized trial of circumcision in Rakai, Uganda...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27892879/cytokine-activation-during-embryonic-development-and-in-hen-ovary-and-vagina-during-reproductive-age-and-salmonella-infection
#14
M Anastasiadou, G Michailidis
Salmonellosis is one of the most important zoonotic diseases and is usually associated with consumption of Salmonella Enteritidis (SE) contaminated poultry meat or eggs. Contamination with SE is usually the result of infection of the digestive tract, or reproductive organs, especially the ovary and vagina. Thus, knowledge of endogenous innate immune mechanisms operating in the ovary and vagina of hen is an emerging aspect of reproductive physiology. Cytokines are key factors for triggering the immune response and inflammation in chicken to Salmonella infection...
December 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27821748/spatiotemporal-dynamics-of-androgen-signaling-underlie-sexual-differentiation-and-congenital-malformations-of-the-urethra-and-vagina
#15
Christine E Larkins, Ana B Enriquez, Martin J Cohn
Disorders of sex development (DSDs) are congenital anomalies that affect sexual differentiation of genitourinary organs and secondary sex characters. A common cause of female genital virilization is congenital adrenal hyperplasia (CAH), in which excess androgen production during development of 46XX females can result in vaginal atresia, masculinization of the urethra, a single urogenital sinus, and clitoral hypertrophy or ambiguous external genitalia. Development of the vagina depends on sexual differentiation of the urogenital sinus ridge, an epithelial thickening that forms where the sex ducts attach to the anterior urethra...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27818685/primary-sjogren-s-syndrome-presenting-as-acute-interstitial-pneumonitis-hamman-rich-syndrome
#16
Abidullah Khan, Mohammad Humayun, Iqbal Haider, Maimoona Ayub, Zakir Shah, Fahad Ajmal
A previously well, 45-year-old Pakistani lady was admitted to the medical unit on-call of Khyber Teaching Hospital (KTH) Peshawar with a 5-day history of fever, productive cough with copious mucoid sputum, dyspnea, and pleuritic chest pain. She also complained of dry eyes, mouth, and vagina. Her chest X-ray showed diffuse alveolar shadowing and arterial gas analysis confirmed type 1 respiratory failure. Over the next few days, she deteriorated rapidly making an urgent transfer to the medical intensive care unit (MICU) necessary, where she was mechanically ventilated...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27754217/os-32-02-effects-of-renin-angiotensin-system-inhibitors-on-vagina-and-cardiac-expression-of-raas-components-in-female-spontaneously-hypertensive-rats
#17
Zhao Yang, Ma Ruixin, Yu Jing
OBJECTIVE: The role of the renin angiotensin aldosterone system (RAAS) and the gene variants of its components in hypertension have been investigated in various studies. A local tissue-specific renin-angiotensin system (local RAS) has considered as a regulator of cardiovascular physiology and homeostasis. However, no report has described the vagina protective efficacy of RAS inhibitors including ARB and ACEI. Therefore, we aim to investigate the effect of ARBs and ACEI on the vagina and cardiac expression of the local renin-angiotensin components...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27694231/genomic-comparisons-of-lactobacillus-crispatus-and-lactobacillus-iners-reveal-potential-ecological-drivers-of-community-composition-in-the-vagina
#18
Michael T France, Helena Mendes-Soares, Larry J Forney
: Lactobacillus crispatus and Lactobacillus iners are common inhabitants of the healthy human vagina. These two species are closely related and are thought to perform similar ecological functions in the vaginal environment. Temporal data on the vaginal microbiome have shown that nontransient instances of cooccurrence are uncommon, while transitions from an L. iners-dominated community to one dominated by L. crispatus, and vice versa, occur often. This suggests that there is substantial overlap in the fundamental niches of these species...
December 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27660826/effect-of-lipopolysaccharide-lps-exposure-on-the-reproductive-organs-of-immature-female-rats
#19
Da Kyung Yoo, Sung-Ho Lee
Lipopolysaccharide (LPS), an endotoxin, elicits strong immune responses in mammals. Several lines of evidence demonstrate that LPS challenge profoundly affects female reproductive function. For example, LPS exposure affects steroidogenesis and folliculogenesis, resulting in delayed puberty onset. The present study was conducted to clarify the mechanism underlying the adverse effect of LPS on the delayed puberty in female rats. LPS was daily injected for 5 days (50 μg/kg, PND 25-29) to treated animals and the date at VO was evaluated through daily visual examination...
June 2016: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/27643177/os-32-02-effects-of-renin-angiotensin-system-inhibitors-on-vagina-and-cardiac-expression-of-raas-components-in-female-spontaneously-hypertensive-rats
#20
Zhao Yang, Ma Ruixin, Yu Jing
OBJECTIVE: The role of the renin angiotensin aldosterone system (RAAS) and the gene variants of its components in hypertension have been investigated in various studies. A local tissue-specific renin-angiotensin system (local RAS) has considered as a regulator of cardiovascular physiology and homeostasis. However, no report has described the vagina protective efficacy of RAS inhibitors including ARB and ACEI. Therefore, we aim to investigate the effect of ARBs and ACEI on the vagina and cardiac expression of the local renin-angiotensin components...
September 2016: Journal of Hypertension
keyword
keyword
82824
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"