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https://www.readbyqxmd.com/read/28900802/assessment-of-m2-anxa5-haplotype-as-a-risk-factor-in-couples-with-placenta-mediated-pregnancy-complications
#1
Nina Rogenhofer, Lara R M Nienaber, Lea C Amshoff, Nadia Bogdanova, David Petroff, Peter Wieacker, Christian J Thaler, Arseni Markoff
PURPOSE: The aim of this study was to confirm the associated M2/ANXA5 carrier risk in women with placenta-mediated pregnancy complications (PMPC) and to test their male partners for such association. Further analysis evaluated the influence of maternal vs. paternal M2 alleles on miscarriage. METHODS: Two hundred eighty-eight couples with preeclampsia (PE), intrauterine growth restriction (IUGR), or premature birth (PB) were recruited (n = 96 of each phenotype)...
September 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28646507/influences-of-placental-growth-factor-on-mouse-retinal-vascular-development
#2
Vanessa R Kay, Chandrakant Tayade, Peter Carmeliet, B Anne Croy
BACKGROUND: Placental growth factor (PGF) is important for wound-healing and vascular collaterogenesis. PGF deficiency is associated with preeclampsia, a hypertensive disease of human pregnancy. Offspring born to preeclamptic mothers display cognitive impairments and brain vascular and neurostructural deviations. Low PGF production during development may contribute to alterations in offspring cerebrovascular beds. Retina is a readily accessible part of the central nervous system with a well-described pattern of vascular development in mice...
June 24, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28471964/prenatal-perinatal-and-postnatal-factors-associated-with-autism-a-meta-analysis
#3
REVIEW
Chengzhong Wang, Hua Geng, Weidong Liu, Guiqin Zhang
BACKGROUND: The aim of this meta-analysis was to investigate the prenatal, perinatal, and postnatal risk factors for children autism. METHODS: PubMed, Embase, Web of Science were used to search for studies that examined the prenatal, perinatal, and postnatal risk factors for children autism. A fixed-effects model or random-effects model was used to pool the overall effect estimates. RESULTS: Data from 37,634 autistic children and 12,081,416 nonautistic children enrolled in 17 studies were collated...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28095355/immune-regulatory-network-in-successful-pregnancy-and-reproductive-failures
#4
REVIEW
Mahnaz Ghaebi, Mohammad Nouri, Aliyeh Ghasemzadeh, Laya Farzadi, Farhad Jadidi-Niaragh, Majid Ahmadi, Mehdi Yousefi
Maternal immune system must tolerate semiallogenic fetus to establish and maintain a successful pregnancy. Despite the existence of several strategies of trophoblast to avoid recognition by maternal leukocytes, maternal immune system may react against paternal alloantigenes. Leukocytes are important components in decidua. Not only T helper (Th)1/Th2 balance, but also regulatory T (Treg) cells play an important role in pregnancy. Although the frequency of Tregs is elevated during normal pregnancies, their frequency and function are reduced in reproductive defects such as recurrent miscarriage and preeclampsia...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27939477/the-paternal-polymorphism-rs5370-in-the-edn1-gene-decreases-the-risk-of-preeclampsia
#5
Carlos Galaviz-Hernandez, Eliakym Arámbula-Meraz, Diana Medina-Bastidas, Martha Sosa-Macías, Blanca P Lazalde-Ramos, Margarita Ortega-Chávez, Lorena Hernandez-García
OBJECTIVE: To evaluate whether the maternal, paternal or the combined maternal/paternal contribution of SNP rs5370 of the EDN1 gene is associated with preeclampsia and drove its expression in placenta. STUDY DESIGN: This case-control study included 61 preeclamptic patients and their partners and 49 healthy pregnant women and their partners. The population was sub-divided into three groups: women-only, men-only and combined (women/men). The analysis included genotyping of rs5370 in mothers and fathers and evaluating the expression profile of the EDN1 gene in placenta...
October 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27508762/-op-5d-06-hypertension-as-a-paternal-factor-influences-maternal-adaptation-to-pregnancy-and-is-associated-with-placental-insufficiency-and-fetal-growth-restriction
#6
G Barrientos, A Uceda, A Sgariglia, G Giardina, S M Blois, J E Toblli
OBJECTIVE: Severe forms of hypertensive disorders of pregnancy, like early-onset preeclampsia (PE), are often linked with abnormal placentation. Genetic factors contributed by the father may be important for placental development, and previous studies support the existence of a paternal component for PE and fetal growth restriction. Thus, the present study was conducted to evaluate the influence of arterial hypertension as a paternal factor on placental development and fetal growth in normal female rats...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26915924/gynecologic-and-obstetric-consequences-of-obesity-in-adolescent-girls
#7
REVIEW
Leticia Elizondo-Montemayor, Claudia Hernández-Escobar, Eduardo Lara-Torre, Bianca Nieblas, Merith Gómez-Carmona
In the past few decades, there has been an overwhelming increase in childhood and adolescent obesity worldwide. Besides the well recognized cardiometabolic complications and other physical conditions associated with obesity, during adolescence, it causes psychological and social distress in a period of life that is already sensitive for a girl. This in turn increases their risk of low self-esteem and depression. Furthermore, obesity diminishes health-related quality of life and years of life. Overweight and obese teenagers are more likely to have gynecologic and obstetric complications, during adolescence and also later in life...
April 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26664892/four-pathways-involving-innate-immunity-in-the-pathogenesis-of-preeclampsia
#8
Kelsey R Bounds, M Karen Newell-Rogers, Brett M Mitchell
The maternal innate immune system plays an important role both in normal pregnancy as well as hypertensive disorders of pregnancy including preeclampsia (PE). We propose four pathways that involve excessive innate immunity that lead to most forms of PE. Pre-existing endothelial dysfunction plus pregnancy leads to an excessive innate immune response resulting in widespread inflammation, placental and renal dysfunction, vasoconstriction, and PE. Placental dysfunction due to shallow trophoblast invasion, inadequate spiral artery remodeling, and/or low placental perfusion initiates an innate immune response leading to excessive inflammation, endothelial and renal dysfunction, and PE...
2015: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/26428489/why-is-placentation-abnormal-in-preeclampsia
#9
REVIEW
Susan J Fisher
The causes of preeclampsia remain one of the great medical mysteries of our time. This syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal inflammatory response. Specific regions of the placenta have distinct pathologic features. During normal pregnancy, cytotrophoblasts emigrate from the chorionic villi and invade the uterus, reaching the inner third of the myometrium. This unusual process is made even more exceptional by the fact that the placental cells are hemiallogeneic, coexpressing maternal and paternal genomes...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26417259/imprinting-genes-associated-with-endometriosis
#10
REVIEW
Hiroshi Kobayashi
PURPOSE: Much work has been carried out to investigate the genetic and epigenetic basis of endometriosis and proposed that endometriosis has been described as an epigenetic disease. The purpose of this study was to extract the imprinting genes that are associated with endometriosis development. METHODS: The information on the imprinting genes can be accessed publicly from a web-based interface at http://www.geneimprint.com/site/genes-by-species. RESULTS: In the current version, the database contains 150 human imprinted genes derived from the literature...
2014: EXCLI journal
https://www.readbyqxmd.com/read/26162698/placental-expression-of-imprinted-genes-varies-with-sampling-site-and-mode-of-delivery
#11
A B Janssen, S J Tunster, N Savory, A Holmes, J Beasley, S A R Parveen, R J A Penketh, R M John
UNLABELLED: Imprinted genes, which are monoallelically expressed by virtue of an epigenetic process initiated in the germline, are known to play key roles in regulating fetal growth and placental development. Numerous studies are investigating the expression of these imprinted genes in the human placenta in relation to common complications of pregnancy such as fetal growth restriction and preeclampsia. This study aimed to determine whether placental sampling protocols or other factors such as fetal sex, gestational age and mode of delivery may influence the expression of imprinted genes predicted to regulate placental signalling...
August 2015: Placenta
https://www.readbyqxmd.com/read/26104639/pre-eclampsia-a-disease-of-an-individual-couple
#12
Gustaaf Albert Dekker
Preeclampsia still ranks as one of obstetrics major problems. Clinicians typically encounter preeclampsia as maternal disease with variable degrees of fetal involvement. More and more the unique immunogenetic maternal-paternal relationship is appreciated, and as such also the specific 'genetic conflict' that is characteristic of haemochorial placentation. From that perspective preeclampsia can also been seen as a disease of an individual couple with primarily maternal and fetal manifestations. Factors that are unique to a specific couple would include the length and type of sexual relationship, the maternal (decidual natural killer cells) acceptation of the invading cytotrophoblast (paternal HLA-C), and seminal levels of transforming growth factor-b and probably other cytokines...
July 2014: Pregnancy Hypertension
https://www.readbyqxmd.com/read/26095815/trophoblast-expression-of-the-minor-histocompatibility-antigen-ha-1-is-regulated-by-oxygen-and-is-increased-in-placentas-from-preeclamptic-women
#13
C Linscheid, E Heitmann, P Singh, E Wickstrom, L Qiu, H Hodes, T Nauser, M G Petroff
INTRODUCTION: Maternal T-cells reactive towards paternally inherited fetal minor histocompatibility antigens are expanded during pregnancy. Placental trophoblast cells express at least four fetal antigens, including human minor histocompatibility antigen 1 (HA-1). We investigated oxygen as a potential regulator of HA-1 and whether HA-1 expression is altered in preeclamptic placentas. METHODS: Expression and regulation of HA-1 mRNA and protein were examined by qRT-PCR and immunohistochemistry, using first, second, and third trimester placentas, first trimester placental explant cultures, and term purified cytotrophoblast cells...
August 2015: Placenta
https://www.readbyqxmd.com/read/26088194/preeclampsia-what-does-the-father-have-to-do-with-it
#14
REVIEW
V Katsi, I Felekos, C Siristatidis, S Kasioni, A Drakontaidis, G Farmakides, T Makris, C Aggeli, P Nihoyannopoulos, D Tousoulis, I Kallikazaros
Preeclampsia (PE) is one of the leading causes of maternal and fetal morbidity and mortality, with incidence rates ranging between 2 and 5 % in the Western World. The exact causes of the disease remain largely unknown, because of the complex pathophysiologic mechanisms involved in the process. Genetic, environmental, and epigenetic parameters have been implicated by various authors as culprits for the pathogenesis of PE. Recent reports in the literature highlight the paternal role. Still, the exact extent and mechanism remain elusive...
August 2015: Current Hypertension Reports
https://www.readbyqxmd.com/read/25918481/perinatal-outcomes-in-hiv-positive-pregnant-women-with-concomitant-sexually-transmitted-infections
#15
COMPARATIVE STUDY
Erin Burnett, Tammy L Loucks, Michael Lindsay
OBJECTIVE: To evaluate whether HIV infected pregnant women with concomitant sexually transmitted infection (STIs) are at increased risk of adverse perinatal and neonatal outcomes. METHODS: We conducted a cohort study of HIV positive women who delivered at an inner-city hospital in Atlanta, Georgia, from 2003 to 2013. Demographics, presence of concomitant STIs, prenatal care information, and maternal and neonatal outcomes were collected. The outcomes examined were the association of the presence of concomitant STIs on the risk of preterm birth (PTB), postpartum hemorrhage, chorioamnionitis, preeclampsia, intrauterine growth restriction, small for gestational age, low Apgar scores, and neonatal intensive care admission...
2015: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25906367/prospective-study-of-pregnancy-outcomes-after-parental-cell-phone-exposure-the-norwegian-mother-and-child-cohort-study
#16
Valborg Baste, Gunnhild Oftedal, Ole Jacob Møllerløkken, Kjell Hansson Mild, Bente E Moen
BACKGROUND: Research about prenatal exposure to electromagnetic fields from cell phones among expectant parents and reproductive outcome is limited. The aim of this article is to investigate the association between pregnancy outcome and parental cell phone exposure in a large prospective study. METHODS: The study was based on the Norwegian Mother and Child Cohort Study conducted during the decade 1999-2009. In that study, pregnant women were recruited before a routine ultrasound examination during gestational week 15; they answered a questionnaire at that time and again around gestational week 30...
July 2015: Epidemiology
https://www.readbyqxmd.com/read/25833255/sexual-dimorphism-in-mir-210-expression-and-mitochondrial-dysfunction-in-the-placenta-with-maternal-obesity
#17
S Muralimanoharan, C Guo, L Myatt, A Maloyan
BACKGROUND: Maternal obesity is a major problem in obstetrics, and the placenta is involved in obesity-related complications via its roles at the maternal-fetal interface. We have recently shown a causative role for micro(mi)RNA-210, a so called 'hypoxamir' regulated by HIF-1α, in mitochondrial dysfunction in placentas from women with preeclampsia. We also reported mitochondrial dysfunction in placentas with maternal obesity. Here we hypothesized that expression of miR-210 is dysregulated in the placentas with obesity...
August 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/25526181/expression-and-significance-of-the-imprinted-gene-peg10-in-placenta-of-patients-with-preeclampsia
#18
X Y Liang, X Chen, Y Z Jin, X O Chen, Q Z Chen
The aim of this study was to investigate the expression and significance of the imprinted gene PEG10 (paternally expressed gene 10) in preeclampsia placental tissue. Quantitative real-time reverse transcriptase polymerase chain reaction and immunohistochemistry to evaluate mRNA and protein expression and distribution of PEG10 in placental tissues obtained from 22 preeclampsia patients (8 patients with mild preeclampsia, 14 cases of severe preeclampsia). At the same time, 22 cases of normal pregnant women served as controls...
2014: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25364653/developmental-origins-of-cardiovascular-disease
#19
Edwina H Yeung, Candace Robledo, Nansi Boghossian, Cuilin Zhang, Pauline Mendola
Although cardiovascular disease has traditionally been viewed as a condition of aging individuals, increasing focus has turned to its developmental origins. Since birthweight has been related to cardiovascular disease risk, research into factors such as gravid conditions that affect fetal growth have grown. Associations between maternal diabetes and childhood obesity from sibling studies suggest a causal role but prospective studies of gestational diabetes remain mixed. Preeclampsia and increased offspring blood pressure has been consistently observed but evidence for other cardiovascular outcomes is lacking...
March 1, 2014: Current Epidemiology Reports
https://www.readbyqxmd.com/read/25342175/uterine-natural-killer-cells-supervisors-of-vasculature-construction-in-early-decidua-basalis
#20
REVIEW
Matthew T Rätsep, Allison M Felker, Vanessa R Kay, Leandra Tolusso, Alexander P Hofmann, B Anne Croy
Mammalian pregnancy involves tremendous de novo maternal vascular construction to adequately support conceptus development. In early mouse decidua basalis (DB), maternal uterine natural killer (uNK) cells oversee this process directing various aspects during the formation of supportive vascular networks. The uNK cells recruited to early implantation site DB secrete numerous factors that act in the construction of early decidual vessels (neoangiogenesis) as well as in the alteration of the structural components of newly developing and existing vessels (pruning and remodeling)...
February 2015: Reproduction: the Official Journal of the Society for the Study of Fertility
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