M A Slim, E H T Lim, L A van Vught, A M Tuip-de Boer, E Rademaker, J L G Haitsma Mulier, J J Engel, P Pickkers, F L van de Veerdonk, A P J Vlaar, L P G Derde, N P Juffermans
While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying these therapies have not been investigated in depth. Our aim is to investigate the association between various immunosuppressive therapies (corticosteroids, tocilizumab and anakinra) and the change in endothelial host response over time in critically ill COVID-19 patients. We conducted a pre-specified multicenter post-hoc analysis in a Dutch cohort of COVID-19 patients admitted to the ICU between March 2020 and September 2021 due to hypoxemic respiratory failure...
April 20, 2024: Scientific Reports