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https://www.readbyqxmd.com/read/29656169/international-multicenter-evaluation-of-a-new-d-dimer-assay-for-the-exclusion-of-venous-thromboembolism-using-standard-and-age-adjusted-cut-offs
#1
Blair Alden Parry, Anna Marie Chang, Sebastian M Schellong, Stacey L House, Gregory J Fermann, Erin K Deadmon, Nicholas J Giordano, Yuchiao Chang, Jason Cohen, Nancy Robak, Adam J Singer, Mary Mulrow, Ellen T Reibling, Samuel Francis, S Michelle Griffin, Jürgen H Prochaska, Barbara Davis, Patricia McNelis, Joao Delgado, Philipp Kümpers, Nikos Werner, Nina T Gentile, Eli Zeserson, Philipp S Wild, Alexander T Limkakeng, Elizabeth Lea Walters, Frank LoVecchio, Daniel Theodoro, Judd E Hollander, Christopher Kabrhel
INTRODUCTION: We sought to determine the test characteristics of an automated INNOVANCE D-dimer assay for the exclusion of pulmonary embolism (PE) and deep venous thrombosis (DVT) in emergency department (ED) patients using standard and age-adjusted cut-offs. METHODS: Cross-sectional, international, multicenter study of consecutive patients with suspected DVT or PE in 24 centers (18 USA, 6 Europe). Evaluated patients had low or intermediate Wells PE or DVT scores...
April 5, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29655808/impact-of-syncope-and-pre-syncope-on-short-term-mortality-in-patients-with-acute-pulmonary-embolism
#2
Loris Roncon, Marco Zuin, Franco Casazza, Cecilia Becattini, Claudio Bilato, Pietro Zonzin
BACKGROUND: Syncope and pre-syncope are well-known symptoms of acute pulmonary embolism (PE). However, data about their impact on short-term mortality are scant. We assess the short-term mortality (30-day) for all-causes in PE patients admitted with syncope or with pre-syncope, according their hemodynamic status at admission. METHODS: Patients from the prospective Italian Pulmonary Embolism Registry (IPER) were included in the study. At admission, subjects were stratified according to 2008 ESC guidelines (as high- and non-high-risk patients)...
April 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29653390/fondaparinux-versus-nadroparin-for-thromboprophylaxis-following-minimally-invasive-esophagectomy-a-randomized-controlled-trial
#3
Jieqiong Song, Lizhen Xuan, Wei Wu, Yaxing Shen, Lijie Tan, Ming Zhong
BACKGROUND: The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS: We conducted a randomized, double-blind, treatment-controlled study. Consecutive patients undergoing MIE randomly received a single dose of either nadroparin 2850 AxaIU (Group H) or fondaparinux 2.5 mg (Group F) daily...
April 4, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29652041/-alternating-pneumocompression-effective-physiotherapeutic-method-for-the-prevention-of-venous-thromboembolic-complications-in-patients-of-medium-and-high-risk-in-the-acute-period-of-the-stroke
#4
I Y Galyaev
BACKGROUND: the patients presenting with severe post-stroke in the acute period of this condition are characterized by the high risk of venous thromboembolic complications (VTEC), with the most dangerous of them being pulmonary embolism that makes an appreciable contribution to the mortality rate of such patients at the hospital stage of their treatment. Among the physical methods for the prevention of VTE, such as wearing graduated compression stockings (GCS), myoelectrostimulation (MES), pneumatic intermittent compression (PIC), only the latter technique has been shown to be efficient when applied for the treatment of surgical patients during the post-stroke period with the level of evidence 2B and the very uncertain parameters of the impact...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29650544/evaluation-and-management-of-right-sided-heart-failure-a-scientific-statement-from-the-american-heart-association
#5
REVIEW
Marvin A Konstam, Michael S Kiernan, Daniel Bernstein, Biykem Bozkurt, Miriam Jacob, Navin K Kapur, Robb D Kociol, Eldrin F Lewis, Mandeep R Mehra, Francis D Pagani, Amish N Raval, Carey Ward
BACKGROUND AND PURPOSE: The diverse causes of right-sided heart failure (RHF) include, among others, primary cardiomyopathies with right ventricular (RV) involvement, RV ischemia and infarction, volume loading caused by cardiac lesions associated with congenital heart disease and valvular pathologies, and pressure loading resulting from pulmonic stenosis or pulmonary hypertension from a variety of causes, including left-sided heart disease. Progressive RV dysfunction in these disease states is associated with increased morbidity and mortality...
April 12, 2018: Circulation
https://www.readbyqxmd.com/read/29645405/outcomes-following-a-negative-computed-tomography-pulmonary-angiography-according-to-pulmonary-embolism-prevalence-a-meta-analysis-of-the-management-outcome-studies
#6
D Belzile, S Jacquet, L Bertoletti, Y Lacasse, C Lambert, J C Lega, S Provencher
BACKGROUND: Outcomes studies have reported the safety of computed tomographic pulmonary angiography (CTPA) as a stand-alone imaging to rule out pulmonary embolism (PE). Whether this can be applied to all clinical probabilities remains controversial. OBJECTIVES: We performed a meta-analysis to determine the proportion of patients with venous thromboembolic events (VTE) despite a negative CTPA according to pretest PE prevalence. METHODS: We searched MEDLINE, EMBASE and the Cochrane Library (1/1990 to 5/2017) for outcomes studies recruiting patients with suspected PE using CTPA as a diagnostic strategy...
April 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29644546/imaging-of-urgencies-and-emergencies-in-the-lung-cancer-patient
#7
REVIEW
Bruno De Potter, Jef Huyskens, Birgitta Hiddinga, Maarten Spinhoven, Annelies Janssens, Jan P van Meerbeeck, Paul M Parizel, Annemie Snoeckx
Lung cancer patients often experience potentially life-threatening medical urgencies and emergencies, which may be a direct or indirect result of the underlying malignancy. This pictorial review addresses the most common thoracic, neurological and musculoskeletal medical emergencies in lung cancer patients, including superior vena cava syndrome, pulmonary embolism, spontaneous pneumothorax, cardiac tamponade, massive haemoptysis, central airway obstruction, oesophagorespiratory fistula, malignant spinal cord compression, carcinomatous meningitis, cerebral herniation and pathological fracture...
April 11, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29644263/treatment-for-unstable-pulmonary-sequestration-injury-in-patient-with-severe-blunt-trauma-a-case-report
#8
Sakiko Hiraki, Yohei Okada, Yusuke Arai, Wataru Ishii, Ryoji Iiduka
Case: Pulmonary sequestration is a congenital malformation characterized by nonfunctioning tissue not communicating with the tracheobronchial tree. As the blood pressure in the artery feeding the sequestrated lung tissue is higher than that in the normal pulmonary artery, the risk of massive hemorrhage in pulmonary sequestration is high. We herein present the first case of a severe blunt trauma patient with unstable pulmonary sequestration injury. Outcome and conclusion: The mechanism of pulmonary sequestration injury is vastly different than that of injury to normal lung...
August 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29643111/cardiovascular-and-cerebrovascular-emergency-department-visits-associated-with-wildfire-smoke-exposure-in-california-in-2015
#9
Zachary S Wettstein, Sumi Hoshiko, Jahan Fahimi, Robert J Harrison, Wayne E Cascio, Ana G Rappold
BACKGROUND: Wildfire smoke is known to exacerbate respiratory conditions; however, evidence for cardiovascular and cerebrovascular events has been inconsistent, despite biological plausibility. METHODS AND RESULTS: A population-based epidemiologic analysis was conducted for daily cardiovascular and cerebrovascular emergency department (ED) visits and wildfire smoke exposure in 2015 among adults in 8 California air basins. A quasi-Poisson regression model was used for zip code-level counts of ED visits, adjusting for heat index, day of week, seasonality, and population...
April 11, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29642798/a-retrospective-study-of-a-new-n-butyl-2-cyanoacrylate-glue-ablation-catheter-incorporated-with-application-guiding-light-for-the-treatment-of-venous-insufficiency-twelve-month-results
#10
Turhan Yavuz, Altay Nihat Acar, Huseyin Aydın, Evren Ekingen
Objective This study aims to present the early results of a retrospective study of the use of novel n-butyl-2-cyanoacrylate (VenaBlock)-based nontumescent endovenous ablation with a guiding light for the treatment of patients with varicose veins. Methods Patients with lower limb venous insufficiency were treated with n-butyl-2-cyanoacrylate (VenaBlock Venous Closure System) between April 2016 and July 2016. The study enrolled adults aged 21-70 years with symptomatic moderate to severe varicosities (C2-C4b) and great saphenous vein reflux lasting longer than 0...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29630072/erratum-to-pulmonary-embolism-concurrent-with-lung-cancer-and-central-emboli-predict-mortality-in-patients-with-lung-cancer-and-pulmonary-embolism
#11
Seung-Ick Cha, Kyung-Min Shin, Jae-Kwang Lim, Seung-Soo Yoo, Shin-Yup Lee, Jaehee Lee, Chang-Ho Kim, Jae-Yong Park, Won-Kee Lee, Chi-Young Jung
[This corrects the article DOI: 10.21037/jtd.2017.12.32.].
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29629359/extended-duration-treatment-of-superficial-vein-thrombosis-of-the-lower-limbs-with-tinzaparin
#12
Konstantinos M Nikolakopoulos, Stavros K Kakkos, Chrysanthi P Papageorgopoulou, Ioannis A Tsolakis
Purpose: To identify risk factors for recurrent thromboembolic events (RTEs) and define the optimum duration of treatment with tinzaparin in patients with superficial vein thrombosis (SVT) of the lower limbs. Materials and Methods: A total of 147 consecutive patients with significant SVT were treated with subcutaneously administered tinzaparin. The composite primary endpoint of the study was RTE, deep-vein thrombosis (DVT) and/or pulmonary embolism (PE) at 120 days...
March 2018: Vascular Specialist International
https://www.readbyqxmd.com/read/29629262/thrombolysis-followed-by-apixaban-for-massive-pulmonary-embolism-and-free-floating-thrombus-in-right-ventricle-in-a-patient-with-breast-cancer
#13
Sergio Fasullo, Nicola Morabito, Sergio Cannizzaro, Gioacchino Cosenza, Vito Pinto, Filippo Ganci, Sebastiano Scalzo, Stefania Davi, Giorgio Maringhini
Free-floating thrombus in the right ventricle, associated with a massive acute pulmonary embolism (PE), is a rare phenomenon. PE is an important clinical entity with considerable mortality despite advances in diagnosis and treatment. The prognosis of PE depends on right ventricular dysfunction, myocardial injury markers, and early treatment. In this report, we present the case of a 71-year-old woman with a history of breast cancer admitted to intensive care unit for PE complicated by syncope. Although our case may seem complex because it is not represented in the guidelines, the result was satisfactory and showed how treatment with new anticoagulants (in this case apixaban) after massive thrombolysis of PE could be considered and included in the new guidelines...
January 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29628683/short-term-outcomes-of-long-duration-versus-short-duration-tourniquet-in-primary-total-knee-arthroplasty-a-randomized-controlled-trial
#14
Raju Vaishya, Amit Kumar Agarwal, Vipul Vijay, Manish Kumar Tiwari
Introduction: A tourniquet is used during the total knee replacement surgery to improve the visibility, to reduce the blood loss and for better cementation. Indirectly it decreases the duration of surgery and enhances the recovery of the patient. Their use however is controversial due to some side effects associated with the use of tourniquet. They may increase the risk of deep vein thrombosis and pulmonary embolism by causing venous stasis, endothelial damage and increased platelet adhesion secondary to distal limb ischemia...
January 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628594/an-unusual-case-of-a-parturient-with-uncorrected-pentalogy-of-fallot-presenting-for-elective-cesarean-section-delivery-of-twins
#15
Ying Ci Ho, Sek Koon Boey, Abey Matthew Varughese Mathews, Hooi Geok See, Nian Chih Hwang
We present a 31-year-old primigravida with uncorrected pentalogy of Fallot, pregnant with monochorionic-diamniotic twins, undergoing elective lower segment cesarean section at 36 weeks gestation. Preoperative workup included a transthoracic echocardiogram which revealed a large ventricular septal defect of 1.8 cm with bidirectional shunting, a moderate size atrial septal defect of 1.8 cm with predominant left-to-right shunting, an overriding aorta, moderate right ventricular hypertrophy, and severe pulmonary valve stenosis...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628478/arrhythmogenic-right-ventricular-cardiomyopathy-with-multiple-thrombi-and-ventricular-tachycardia-of-atypical-left-branch-bundle-block-morphology
#16
Shenzhen Gong, Xin Wei, Guyue Liu, Feng Wu, Xiaoping Chen
A 61-year-old male patient was admitted to our hospital with recurrent palpitations and syncope. Electrocardiography, echocardiography, and contrast-enhanced computed tomography were performed. The patient was diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) complicated by multiple thrombi, and ventricular tachycardia (VT) without typical left bundle branch block (LBBB) morphology. This case suggests that VT is not always the sole contributor to syncope and death in patients with ARVC, and pulmonary embolism should be considered...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29628339/ischemic-stroke-secondary-to-paradoxical-embolism-through-a-pulmonary-arteriovenous-malformation-case-report-and-review-of-the-literature
#17
Ryan Cappa, Jeanette Du, Joseph F Carrera, Jimmy V Berthaud, Andrew M Southerland
Paradoxical embolism due to isolated pulmonary arteriovenous malformation (AVM) is an uncommon cause of ischemic stroke, with the majority occurring in patients who have not yet been diagnosed with their malformation. We report a 32-year-old man who presented with an abrupt onset of right facial weakness and expressive aphasia. Brain magnetic resonance imaging revealed an acute infarct in the left middle cerebral artery territory and chronic infarcts in the bilateral cerebellar hemispheres. A cardioembolic mechanism was initially considered in the setting of perimyocarditis diagnosed a few months earlier...
April 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29626452/peripheral-distribution-of-thrombus-does-not-affect-outcomes-after-surgical-pulmonary-embolectomy
#18
Chetan Pasrija, Aakash Shah, Praveen George, Isa Mohammed, Francis A Brigante, Mehrdad Ghoreishi, Jean Jeudy, Bradley S Taylor, James S Gammie, Bartley P Griffith, Zachary N Kon
BACKGROUND: Thrombus located distal to the main or primary pulmonary arteries has been previously viewed as a relative contraindication to surgical pulmonary embolectomy. We compared outcomes for surgical pulmonary embolectomy for submassive and massive pulmonary embolism (PE) in patients with central versus peripheral thrombus burden. METHODS: All consecutive patients (2011-2016) undergoing surgical pulmonary embolectomy at a single center were retrospectively reviewed...
April 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29625928/serum-free-light-chain-difference-and-%C3%AE-2-microglobulin-levels-are-risk-factors-for-thromboembolic-events-in-patients-with-al-amyloidosis
#19
Hyunkyung Park, Ji-Won Kim, Jeonghwan Youk, Youngil Koh, Jeong-Ok Lee, Ki Hwan Kim, Soo-Mee Bang, Inho Kim, Seonyang Park, Sung-Soo Yoon
BACKGROUND: AL amyloidosis might increase the risk of thromboembolism and other plasma cell dyscrasias; however, only a few reports have described the clinical features of thromboembolism. The present study aimed to elucidate the clinical features of thromboembolic events and to identify the risk factors for these events. MATERIALS AND METHODS: The medical records were retrospectively reviewed to define the clinically significant thromboembolic events. RESULTS: A total of 106 patients with biopsy-proven AL amyloidosis were included...
March 15, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29623992/diagnostic-utility-of-an-age-specific-cut-off-for-d-dimer-for-pulmonary-embolism-assessment-when-used-with-various-pulmonary-embolism-risk-scores
#20
Imogen Ackerly, Sharon Klim, James McFarlane, Anne-Maree Kelly
This retrospective cohort study compared the diagnostic utility (sensitivity, specificity and negative predictive value (NPV)) of the age-times-10 adjusted d-dimer cut-off used in combination with the original and simplified Well's pulmonary embolism (PE) scores and the original and simplified revised Geneva scores to identify patients in whom PE is classified as unlikely according to each score. The PE risk scores performed similarly with high sensitivity (97.6, 97.1, 96.9 and 97.1% respectively) and NPV (99...
April 2018: Internal Medicine Journal
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