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https://www.readbyqxmd.com/read/27919004/irbesartan-ameliorates-hyperlipidemia-and-liver-steatosis-in-type-2-diabetic-db-db-mice-via-stimulating-ppar-%C3%AE-ampk-akt-mtor-signaling-and-autophagy
#1
Juan Zhong, Wangqiu Gong, Lu Lu, Jing Chen, Zibin Lu, HongYu Li, Wenting Liu, Yangyang Liu, Mingqing Wang, Rong Hu, Haibo Long, Lianbo Wei
Irbesartan (Irb), a unique subset of angiotensin II receptor blockers (ARBs) with PPAR-γ activation function, has been reported to play a role in renal dysfunction, glucose metabolism, and abnormal lipid profile in diabetic animal models and humans. However, the underlying mechanisms that improve hyperlipidemia and liver steatosis are unclear. This study investigated the effects of Irb on lipid metabolism and hepatic steatosis using the spontaneous type 2 diabetic db/db mouse model. The results demonstrated body and liver weight, food consumption, lipid content in serum and liver tissue, and liver dysfunction as well as hepatic steatosis were increased in db/db mice compared with db/m mice, whereas the increases were reversed by Irb treatment...
December 2, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27851610/1976-severe-hyperkalemia-with-trimethoprim-sulfamethoxazole-and-irbesartan-use-a-near-death-consequence
#2
Jaspreet Dhami, Harish Devineni, Christopher Milnes, Sunil Jagadesh
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27829955/efficacy-and-safety-of-a-single-pill-fixed-dose-combination-of-azilsartan-and-amlodipine
#3
Kota Motozato, Shin-Ichiro Miura, Yuhei Shiga, Takaaki Kusumoto, Keijiro Saku
BACKGROUND: Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications. There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at reducing blood pressure (BP). METHODS: Forty hypertensive patients who were receiving a single-pill fixed-dose combination of valsartan 80 mg/day and amlodipine 5 mg/day or irbesartan 100 mg/day and amlodipine 5 mg/day were enrolled...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829706/corrigendum-to-irbesartan-ameliorates-diabetic-nephropathy-by-suppressing-the-rankl-rank-nf-%C3%AE%C2%BAb-pathway-in-type-2-diabetic-db-db-mice
#4
Xiao-Wen Chen, Xiao-Yan Du, Yu-Xian Wang, Jian-Cheng Wang, Wen-Ting Liu, Wen-Jing Chen, Hong-Yu Li, Fen-Fen Peng, Zhao-Zhong Xu, Hong-Xin Niu, Hai-Bo Long
[This corrects the article DOI: 10.1155/2016/1405924.].
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27814397/the-interplay-between-the-renin-angiotensin-system-and-pacing-postconditioning-induced-cardiac-protection
#5
Fawzi Babiker, Aishah Al-Jarallah, Shaji Joseph
BACKGROUND: Accumulating evidence suggests a cardioprotective role of pacing postconditioning (PPC) maneuvers in animal models and more recently in humans. The procedure however remains to be optimized and its interaction with physiological systems remains to be further explored. The renin angiotensin system (RAS) plays a dual role in ischemia/reperfusion (I/R) injury. The interaction between RAS and PPC induced cardiac protection is however not clearly understood. We have recently demonstrated that angiotensin (1-7) via Mas receptor played a significant role in PPC mediated cardiac protection against I/R injury...
2016: PloS One
https://www.readbyqxmd.com/read/27804233/quality-of-life-development-during-initial-hemodialysis-therapy-and-association-with-loss-of-residual-renal-function
#6
Christina G Poulsen, Krista D Kjaergaard, Christian D Peters, Bente Jespersen, Jens D Jensen
Introduction Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated the course of self-reported HRQOL over time and the association with selected factors, focusing on changes in glomerular filtration rate (GFR). Methods Eighty-two newly started hemodialysis patients from the SAFIR cohort filled out the Kidney Disease Quality of Life Short Form Version 1.3 (KDQOL-SF(TM) ) questionnaire at baseline, 6 and 12 months. The SAFIR study was a randomized, placebo-controlled, double-blind intervention study, examining the effects of the angiotensin II receptor blocker irbesartan...
November 1, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27794380/effect-and-mechanism-of-irbesartan-on-occurrence-of-ventricular-arrhythmias-in-rats-with-myocardial-ischemia-through-connexin43-cx43
#7
Tao Wu, Dan Wu, Qinghua Wu, Bing Zou, Xiao Huang, Xiaoshu Cheng, Yanqing Wu, Kui Hong, Ping Li
OBJECTIVE: To explore the effect and mechanism of angiotensin II receptor blockers - Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. METHODS: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group, ischemia group, Irbesartan group and Irbesartan + ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43 (Cx43) mRNA and western blot to detect the expression of Cx43 and phosphorylated Cx43...
October 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27773659/ascending-aortic-adventitial-remodeling-and-fibrosis-are-ameliorated-with-apelin-13-in-rats-after-tac-via-suppression-of-the-mirna-122-and-lgr4-%C3%AE-catenin-signaling
#8
Ran Xu, Zhen-Zhou Zhang, Lai-Jiang Chen, Hui-Min Yu, Shu-Jie Guo, Ying-Le Xu, Gavin Y Oudit, Yan Zhang, Qing Chang, Bei Song, Dong-Rui Chen, Ding-Liang Zhu, Jiu-Chang Zhong
Apelin has been proved to be a critical mediator of vascular function and homeostasis. Here, we investigated roles of Apelin in aortic remodeling and fibrosis in rats with transverse aortic constriction (TAC). Male Sprague-Dawley rats were subjected to TAC and then randomized to daily deliver Apelin-13 (50μg/kg) or angiotensin type 1 receptor (AT1) blocker Irbesartan (50mg/kg) for 4 weeks. Pressure overload resulted in myocardial hypertrophy, systolic dysfunction, aortic remodeling and adventitial fibrosis with reduced levels of Apelin in ascending aortas of rat after TAC compared with sham-operated group...
December 2016: Peptides
https://www.readbyqxmd.com/read/27771847/multicenter-randomized-double-blind-comparison-of-nebivolol-plus-hctz-and-irbesartan-plus-hctz-in-the-treatment-of-isolated-systolic-hypertension-in-elderly-patients-results-of-the-nehis-study
#9
Guido Grassi, Gino Seravalle, Gianmaria Brambilla, Raffaella Dell'Oro, Fosca Quarti Trevano, Francesco Fici, Luc van Bortel, Giuseppe Mancia
INTRODUCTION: The present study was aimed at comparing the antihypertensive efficacy, tolerability, and side effects profile of nebivolol/hydrochlorothiazide (NH) vs irbesartan/hydrochlorothiazide (IH) combination in elderly patients with isolated systolic hypertension (ISH). METHODS: 124 ISH patients aged 69.1 ± 5.1 years (mean ± SD) were enrolled by 13 general practitioners in Netherlands and Belgium and randomized in a double-blind fashion to receive either NH (5/12...
October 22, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27756096/protective-effect-of-irbesartan-an-angiotensin-at1-receptor-antagonist-in-unpredictable-chronic-mild-stress-induced-depression-in-mice
#10
M Ayyub, A K Najmi, M Akhtar
Objective: Oxidative stress and alternation of renin-angiotensin system has been implicated in the pathophysiology of various cardio vascular, endocrine including mood and anxiety disorders. The present study evaluated the role of irbesartan in stress induced different models of depression. Materials and method: Mice were treated with irbesartan (40 mg/kg), fluoxetine (25 mg/kg) alone in combination orally. Drugs treatment started after 2 weeks from the beginning of the unpredictable mild stress (UCMS) protocol...
October 18, 2016: Drug Research
https://www.readbyqxmd.com/read/27755389/copeptin-is-increased-in-resistant-hypertension
#11
Margarida Mendes, Julie Dubourg, Anne Blanchard, Damien Bergerot, Pierre-Yves Courand, Valentina Forni, Michael Frank, Guillaume Bobrie, Joel Menard, Michel Azizi
OBJECTIVES: The participation of vasopressin in the mechanisms of resistant hypertension is unclear. We compared plasma copeptin concentration, a surrogate marker for vasopressin secretion, between patients with resistant hypertension and those with controlled blood pressure (CBP), in a post hoc analysis of the Prise en charge de l'Hypertension Artérielle RESistante au traitement trial. METHODS: After 4-week treatment with irbesartan 300 mg/day, hydrochlorothiazide 12...
October 15, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753922/os-04-06-how-to-control-high-blood-pressure-after-coronary-revascularization-in-patients-referred-to-in-house-cardiac-rehabilitation-single-center-experience
#12
Ivana Burazor, Stamenko Susak
OBJECTIVE: After stent or bypass surgery blood pressure (BP) can go up for multiple reasons among which are: stress and tense of the patient unsure about the future, the pain of the cut and because some of the blood pressure medication, which the patient was receiving preoperatively may get withdrawn post operatively, thereby leading to shooting up the BP. In certain patients, BP actually comes down after surgery and returns back to the pre-operative levels 4 to 6 weeks down the track...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27750081/metabolomics-insights-into-activated-redox-signaling-and-lipid-metabolism-dysfunction-in-chronic-kidney-disease-progression
#13
Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao
Early detection is critical in prevention and treatment of kidney disease. However currently clinical laboratory and histopathological tests do not provide region-specific and accurate biomarkers for early detection of kidney disease. The present study was conducted to identify sensitive biomarkers for early detection and progression of tubulo-interstitial nephropathy in aristolochic acid I-induced rats at weeks 4, 8 and 12. Biomarkers were validated using aristolochic acid nephropathy (AAN) rats at week 24, adenine-induced chronic kidney disease (CKD) rats and CKD patients...
September 28, 2016: Redox Biology
https://www.readbyqxmd.com/read/27746855/bilateral-renal-denervation-ameliorates-isoproterenol-induced-heart-failure-through-downregulation-of-the-brain-renin-angiotensin-system-and-inflammation-in-rat
#14
Jian-Dong Li, Ai-Yuan Cheng, Yan-Li Huo, Jie Fan, Yu-Ping Zhang, Zhi-Qin Fang, Hong-Sheng Sun, Wei Peng, Jin-Shun Zhang, Hai-Ping Wang, Bao-Jian Xue
Heart failure (HF) is characterized by cardiac dysfunction along with autonomic unbalance that is associated with increased renin-angiotensin system (RAS) activity and elevated levels of proinflammatory cytokines (PICs). Renal denervation (RD) has been shown to improve cardiac function in HF, but the protective mechanisms remain unclear. The present study tested the hypothesis that RD ameliorates isoproterenol- (ISO-) induced HF through regulation of brain RAS and PICs. Chronic ISO infusion resulted in remarked decrease in blood pressure (BP) and increase in heart rate and cardiac dysfunction, which was accompanied by increased BP variability and decreased baroreflex sensitivity and HR variability...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27742464/blood-pressure-and-cholesterol-lowering-efficacy-of-a-fixed-dose-combination-with-irbesartan-and-atorvastatin-in-patients-with-hypertension-and-hypercholesterolemia-a-randomized-double-blind-factorial-multicenter-phase-iii-study
#15
Sang-Hyun Kim, Sang-Ho Jo, Sang-Cheol Lee, Sung-Yoon Lee, Myung-Ho Yoon, Hyang-Lim Lee, Nae-Hee Lee, Jong-Won Ha, Nam-Ho Lee, Dong-Woon Kim, Gyu-Rok Han, Min-Su Hyon, Deok-Gyu Cho, Chang-Gyu Park, Young-Dae Kim, Gyu-Hyung Ryu, Cheol-Ho Kim, Kee-Sik Kim, Myung-Ho Chung, Sung-Chul Chae, Ki-Bae Seung, Byung-Hee Oh
PURPOSE: A fixed-dose combination of a stain and an antihypertensive drug may be useful for the treatment of patients with hypertension and hyperlipidemia. It may also improve patient drug compliance to help control risk factors of cardiovascular disease. This study was designed to evaluate the blood pressure-lowering and cholesterol-lowering effect of a fixed-dose combination of irbesartan-atorvastatin compared with monotherapy by either agent over an 8-week treatment period. METHODS: Patients with comorbid hypertension and hypercholesterolemia were screened for this randomized, double-blind, Phase III study...
October 11, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27646835/randomized-multicentre-pilot-study-of-sacubitril-valsartan-versus-irbesartan-in-patients-with-chronic-kidney-disease-united-kingdom-heart-and-renal-protection-harp-iii-rationale-trial-design-and-baseline-data
#16
(no author information available yet)
BACKGROUND: Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis. METHODS: UK Heart and Renal Protection III (HARP-III) is a multicentre, double-blind, randomized controlled trial comparing sacubitril/valsartan 97/103 mg two times daily (an angiotensin receptor-neprilysin inhibitor) with irbesartan 300 mg one time daily among 414 patients with CKD...
September 19, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27643315/os-04-06-how-to-control-high-blood-pressure-after-coronary-revascularization-in-patients-referred-to-in-house-cardiac-rehabilitation-single-center-experience
#17
Ivana Burazor, Stamenko Susak
OBJECTIVE: After stent or bypass surgery blood pressure (BP) can go up for multiple reasons among which are: stress and tense of the patient unsure about the future, the pain of the cut and because some of the blood pressure medication, which the patient was receiving preoperatively may get withdrawn post operatively, thereby leading to shooting up the BP. In certain patients, BP actually comes down after surgery and returns back to the pre-operative levels 4 to 6 weeks down the track...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27621182/regulation-of-the-ku70-and-apoptosis-related-proteins-in-experimental-diabetic-nephropathy
#18
Matem Tunçdemir, Melek Öztürk
BACKGROUND: Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats. MATERIALS AND METHODS: Animals were divided into five groups of eight each, four of which received STZ (60mg/kg in a single dose, i...
October 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27603418/vitamin-d-binding-protein-is-a-potential-urinary-biomarker-of-irbesartan-treatment-response-in-patients-with-iga-nephropathy
#19
Jiashun Zeng, Qiong Wen, Rong Rong, Fengxian Huang, Qiongqiong Yang, Xueqing Tang, Feng He, Naya Huang, Xueqing Yu
AIMS: The purpose of this study was to identify predictive markers of irbesartan (an angiotensin receptor blocker) treatment response in immunoglobulin A nephropathy (IgAN) patients. METHODS: Urine samples were collected both before and after irbesartan treatment in IgAN patients and compared with urine from healthy volunteers. The total urinary protein produced in 24 h was measured to determine therapeutic response. The urinary proteome was evaluated by two-dimensional gel electrophoresis coupled with MALDI-TOF-MS/MS analysis...
September 7, 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27576780/adherence-to-antihypertensive-treatment-and-the-blood-pressure-lowering-effects-of-renal-denervation-in-the-renal-denervation-for-hypertension-denerhtn-trial
#20
Michel Azizi, Helena Pereira, Idir Hamdidouche, Philippe Gosse, Matthieu Monge, Guillaume Bobrie, Pascal Delsart, Claire Mounier-Véhier, Pierre-Yves Courand, Pierre Lantelme, Thierry Denolle, Caroline Dourmap-Collas, Xavier Girerd, Jean Michel Halimi, Faiez Zannad, Olivier Ormezzano, Bernard Vaïsse, Daniel Herpin, Jean Ribstein, Bernard Chamontin, Jean-Jacques Mourad, Emile Ferrari, Pierre-François Plouin, Vincent Jullien, Marc Sapoval, Gilles Chatellier
BACKGROUND: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report the influence of adherence to antihypertensive treatment on blood pressure control. METHODS: One hundred six patients with hypertension resistant to 4 weeks of treatment with indapamide 1.5 mg/d, ramipril 10 mg/d (or irbesartan 300 mg/d), and amlodipine 10 mg/d were randomly assigned to renal denervation plus standardized stepped-care antihypertensive treatment, or the same antihypertensive treatment alone...
September 20, 2016: Circulation
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