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https://www.readbyqxmd.com/read/28101724/drug-drug-multicomponent-solid-forms-cocrystal-coamorphous-and-eutectic-of-three-poorly-soluble-antihypertensive-drugs-using-mechanochemical-approach
#1
Jamshed Haneef, Renu Chadha
The present study deals with the application of mechanochemical approach for the preparation of drug-drug multicomponent solid forms of three poorly soluble antihypertensive drugs (telmisartan, irbesartan and hydrochlorothiazide) using atenolol as a coformer. The resultant solid forms comprise of cocrystal (telmisartan-atenolol), coamorphous (irbesartan-atenolol) and eutectic (hydrochlorothiazide-atenolol). The study emphasizes that solid-state transformation of drug molecules into new forms is a result of the change in structural patterns, diminishing of dimers and creating new facile hydrogen bonding network based on structural resemblance...
January 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28052977/clinical-and-echocardiographic-characteristics-and-cardiovascular-outcomes-according-to-diabetes-status-in-patients-with-heart-failure-and-preserved-ejection-fraction-a-report-from-the-irbesartan-in-heart-failure-with-preserved-ejection-fraction-trial-i-preserve
#2
Søren L Kristensen, Ulrik M Mogensen, Pardeep S Jhund, Mark C Petrie, David Preiss, Sithu Win, Lars Køber, Robert S McKelvie, Michael R Zile, Inder S Anand, Michel Komajda, John S Gottdiener, Peter E Carson, John J V McMurray
BACKGROUND: -In patients with HF and preserved ejection fraction (HFpEF), little is known about the characteristics of and outcomes in those with and without diabetes. METHODS: -We examined clinical and echocardiographic characteristics and outcomes in the Irbesartan in Heart Failure with Preserved Ejection Fraction trial (I-Preserve), according to history of diabetes. Cox regression models were used to estimate hazard ratios (HR) for cardiovascular outcomes adjusted for known predictors, including age, sex, natriuretic peptides, and comorbidity...
January 4, 2017: Circulation
https://www.readbyqxmd.com/read/27951594/beneficial-effects-of-combined-at1-receptor-neprilysin-inhibition-arni-versus-at1-receptor-blockade-alone-in-the-diabetic-eye
#3
Tuhina Prasad, Lodi C W Roksnoer, Ping Zhu, Amrisha Verma, Yiming Li, Wendy W Batenburg, René de Vries, A H Jan Danser, Qiuhong Li
Purpose: Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial effects on progression of DR in clinical trials. The natriuretic peptide system offsets RAS, so that enhancing the activity of this system on top of RAS blockade might be beneficial. Neprilysin has an important role in the degradation of natriuretic peptides. Therefore, we hypothesize that dual angiotensin receptor-neprilysin inhibition (ARNI) may outperform angiotensin receptor blocker (ARB) in protection against DR...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27943353/two-selective-hptlc-methods-for-determination-of-some-angiotensin-ii-receptor-antagonists-in-tablets-and-biological-fluids
#4
Gamal A Salah, Hanaa M Abd El-Wadood, Mohamed Khairy, Ahmed A Khorshed
Two simple, selective, precise and highly sensitive high performance thin layer chromatographic (HPTLC) methods have been developed and validated for analysis of five angiotensin II receptor antagonists namely losartan, irbesartan valsartan, candesartan and olmesartan which widely used in clinical practice. High performance TLC of the drugs was performed on pre-coated silica gel HPTLC plates 60 F254 by development using mobile phase composed of chloroform: acetone: glacial acetic acid (7.8: 1.5: 0.7 v/v/v) which suitable for all of the studied drugs...
December 10, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27936999/effect-of-single-pill-irbesartan-amlodipine-combination-based-therapy-on-clinic-and-home-blood-pressure-profiles-in-hypertension-with-chronic-kidney-diseases
#5
RANDOMIZED CONTROLLED TRIAL
Ryu Kobayashi, Kouichi Tamura, Hiromichi Wakui, Masato Ohsawa, Kengo Azushima, Sona Haku, Kazushi Uneda, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Satoshi Umemura
We examined the efficacy of single-pill irbesartan/amlodipine combination-based therapy for 12 weeks in 20 hypertensive chronic kidney disease (CKD) patients, by evaluating self-measured home blood pressure (BP) profile. The single-pill irbesartan/amlodipine combination-based therapy decreased clinic BP and home BP (morning, evening, and nighttime BPs), and improved within-visit clinic BP variability, day-by-day home BP variability (morning and evening), and nighttime home BP variability. Furthermore, the single-pill combination-based therapy reduced albuminuria and exerted improved parameters of vascular function...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27932705/possible-role-for-glomerular-derived-angiotensinogen-in-nephrotic-syndrome
#6
Mihoko Yamazaki, Yoshiyasu Fukusumi, Mutsumi Kayaba, Yukina Kitazawa, Sayuri Takamura, Ichiei Narita, Hiroshi Kawachi
BACKGROUND AND OBJECTIVE: Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed the glomerular expression of RAS components in nephrotic models and the effect of Ang II receptor blockers (ARB) on the expression of angiotensinogen (AGT)...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27919004/irbesartan-ameliorates-hyperlipidemia-and-liver-steatosis-in-type-2-diabetic-db-db-mice-via-stimulating-ppar-%C3%AE-ampk-akt-mtor-signaling-and-autophagy
#7
Juan Zhong, Wangqiu Gong, Lu Lu, Jing Chen, Zibin Lu, HongYu Li, Wenting Liu, Yangyang Liu, Mingqing Wang, Rong Hu, Haibo Long, Lianbo Wei
Irbesartan (Irb), a unique subset of angiotensin II receptor blockers (ARBs) with PPAR-γ activation function, has been reported to play a role in renal dysfunction, glucose metabolism, and abnormal lipid profile in diabetic animal models and humans. However, the underlying mechanisms that improve hyperlipidemia and liver steatosis are unclear. This study investigated the effects of Irb on lipid metabolism and hepatic steatosis using the spontaneous type 2 diabetic db/db mouse model. The results demonstrated body and liver weight, food consumption, lipid content in serum and liver tissue, and liver dysfunction as well as hepatic steatosis were increased in db/db mice compared with db/m mice, whereas the increases were reversed by Irb treatment...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27851610/1976-severe-hyperkalemia-with-trimethoprim-sulfamethoxazole-and-irbesartan-use-a-near-death-consequence
#8
Jaspreet Dhami, Harish Devineni, Christopher Milnes, Sunil Jagadesh
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27829955/efficacy-and-safety-of-a-single-pill-fixed-dose-combination-of-azilsartan-and-amlodipine
#9
Kota Motozato, Shin-Ichiro Miura, Yuhei Shiga, Takaaki Kusumoto, Keijiro Saku
BACKGROUND: Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications. There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at reducing blood pressure (BP). METHODS: Forty hypertensive patients who were receiving a single-pill fixed-dose combination of valsartan 80 mg/day and amlodipine 5 mg/day or irbesartan 100 mg/day and amlodipine 5 mg/day were enrolled...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829706/corrigendum-to-irbesartan-ameliorates-diabetic-nephropathy-by-suppressing-the-rankl-rank-nf-%C3%AE%C2%BAb-pathway-in-type-2-diabetic-db-db-mice
#10
Xiao-Wen Chen, Xiao-Yan Du, Yu-Xian Wang, Jian-Cheng Wang, Wen-Ting Liu, Wen-Jing Chen, Hong-Yu Li, Fen-Fen Peng, Zhao-Zhong Xu, Hong-Xin Niu, Hai-Bo Long
[This corrects the article DOI: 10.1155/2016/1405924.].
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27814397/the-interplay-between-the-renin-angiotensin-system-and-pacing-postconditioning-induced-cardiac-protection
#11
Fawzi Babiker, Aishah Al-Jarallah, Shaji Joseph
BACKGROUND: Accumulating evidence suggests a cardioprotective role of pacing postconditioning (PPC) maneuvers in animal models and more recently in humans. The procedure however remains to be optimized and its interaction with physiological systems remains to be further explored. The renin angiotensin system (RAS) plays a dual role in ischemia/reperfusion (I/R) injury. The interaction between RAS and PPC induced cardiac protection is however not clearly understood. We have recently demonstrated that angiotensin (1-7) via Mas receptor played a significant role in PPC mediated cardiac protection against I/R injury...
2016: PloS One
https://www.readbyqxmd.com/read/27804233/quality-of-life-development-during-initial-hemodialysis-therapy-and-association-with-loss-of-residual-renal-function
#12
Christina G Poulsen, Krista D Kjaergaard, Christian D Peters, Bente Jespersen, Jens D Jensen
Introduction Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated the course of self-reported HRQOL over time and the association with selected factors, focusing on changes in glomerular filtration rate (GFR). Methods Eighty-two newly started hemodialysis patients from the SAFIR cohort filled out the Kidney Disease Quality of Life Short Form Version 1.3 (KDQOL-SF(TM) ) questionnaire at baseline, 6 and 12 months. The SAFIR study was a randomized, placebo-controlled, double-blind intervention study, examining the effects of the angiotensin II receptor blocker irbesartan...
November 1, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27794380/effect-and-mechanism-of-irbesartan-on-occurrence-of-ventricular-arrhythmias-in-rats-with-myocardial-ischemia-through-connexin43-cx43
#13
Tao Wu, Dan Wu, Qinghua Wu, Bing Zou, Xiao Huang, Xiaoshu Cheng, Yanqing Wu, Kui Hong, Ping Li
OBJECTIVE: To explore the effect and mechanism of angiotensin II receptor blockers - Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. METHODS: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group, ischemia group, Irbesartan group and Irbesartan + ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43 (Cx43) mRNA and western blot to detect the expression of Cx43 and phosphorylated Cx43...
October 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27773659/ascending-aortic-adventitial-remodeling-and-fibrosis-are-ameliorated-with-apelin-13-in-rats-after-tac-via-suppression-of-the-mirna-122-and-lgr4-%C3%AE-catenin-signaling
#14
Ran Xu, Zhen-Zhou Zhang, Lai-Jiang Chen, Hui-Min Yu, Shu-Jie Guo, Ying-Le Xu, Gavin Y Oudit, Yan Zhang, Qing Chang, Bei Song, Dong-Rui Chen, Ding-Liang Zhu, Jiu-Chang Zhong
Apelin has been proved to be a critical mediator of vascular function and homeostasis. Here, we investigated roles of Apelin in aortic remodeling and fibrosis in rats with transverse aortic constriction (TAC). Male Sprague-Dawley rats were subjected to TAC and then randomized to daily deliver Apelin-13 (50μg/kg) or angiotensin type 1 receptor (AT1) blocker Irbesartan (50mg/kg) for 4 weeks. Pressure overload resulted in myocardial hypertrophy, systolic dysfunction, aortic remodeling and adventitial fibrosis with reduced levels of Apelin in ascending aortas of rat after TAC compared with sham-operated group...
December 2016: Peptides
https://www.readbyqxmd.com/read/27771847/multicenter-randomized-double-blind-comparison-of-nebivolol-plus-hctz-and-irbesartan-plus-hctz-in-the-treatment-of-isolated-systolic-hypertension-in-elderly-patients-results-of-the-nehis-study
#15
Guido Grassi, Gino Seravalle, Gianmaria Brambilla, Raffaella Dell'Oro, Fosca Quarti Trevano, Francesco Fici, Luc van Bortel, Giuseppe Mancia
INTRODUCTION: The present study was aimed at comparing the antihypertensive efficacy, tolerability, and side effects profile of nebivolol/hydrochlorothiazide (NH) vs irbesartan/hydrochlorothiazide (IH) combination in elderly patients with isolated systolic hypertension (ISH). METHODS: 124 ISH patients aged 69.1 ± 5.1 years (mean ± SD) were enrolled by 13 general practitioners in Netherlands and Belgium and randomized in a double-blind fashion to receive either NH (5/12...
October 22, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27756096/protective-effect-of-irbesartan-an-angiotensin-at1-receptor-antagonist-in-unpredictable-chronic-mild-stress-induced-depression-in-mice
#16
M Ayyub, A K Najmi, M Akhtar
Objective: Oxidative stress and alternation of renin-angiotensin system has been implicated in the pathophysiology of various cardio vascular, endocrine including mood and anxiety disorders. The present study evaluated the role of irbesartan in stress induced different models of depression. Materials and method: Mice were treated with irbesartan (40 mg/kg), fluoxetine (25 mg/kg) alone in combination orally. Drugs treatment started after 2 weeks from the beginning of the unpredictable mild stress (UCMS) protocol...
January 2017: Drug Research
https://www.readbyqxmd.com/read/27755389/copeptin-is-increased-in-resistant-hypertension
#17
Margarida Mendes, Julie Dubourg, Anne Blanchard, Damien Bergerot, Pierre-Yves Courand, Valentina Forni, Michael Frank, Guillaume Bobrie, Joel Menard, Michel Azizi
OBJECTIVES: The participation of vasopressin in the mechanisms of resistant hypertension is unclear. We compared plasma copeptin concentration, a surrogate marker for vasopressin secretion, between patients with resistant hypertension and those with controlled blood pressure (CBP), in a post hoc analysis of the Prise en charge de l'Hypertension Artérielle RESistante au traitement trial. METHODS: After 4-week treatment with irbesartan 300 mg/day, hydrochlorothiazide 12...
October 15, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753922/os-04-06-how-to-control-high-blood-pressure-after-coronary-revascularization-in-patients-referred-to-in-house-cardiac-rehabilitation-single-center-experience
#18
Ivana Burazor, Stamenko Susak
OBJECTIVE: After stent or bypass surgery blood pressure (BP) can go up for multiple reasons among which are: stress and tense of the patient unsure about the future, the pain of the cut and because some of the blood pressure medication, which the patient was receiving preoperatively may get withdrawn post operatively, thereby leading to shooting up the BP. In certain patients, BP actually comes down after surgery and returns back to the pre-operative levels 4 to 6 weeks down the track...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27750081/metabolomics-insights-into-activated-redox-signaling-and-lipid-metabolism-dysfunction-in-chronic-kidney-disease-progression
#19
Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao
Early detection is critical in prevention and treatment of kidney disease. However currently clinical laboratory and histopathological tests do not provide region-specific and accurate biomarkers for early detection of kidney disease. The present study was conducted to identify sensitive biomarkers for early detection and progression of tubulo-interstitial nephropathy in aristolochic acid I-induced rats at weeks 4, 8 and 12. Biomarkers were validated using aristolochic acid nephropathy (AAN) rats at week 24, adenine-induced chronic kidney disease (CKD) rats and CKD patients...
September 28, 2016: Redox Biology
https://www.readbyqxmd.com/read/27746855/bilateral-renal-denervation-ameliorates-isoproterenol-induced-heart-failure-through-downregulation-of-the-brain-renin-angiotensin-system-and-inflammation-in-rat
#20
Jian-Dong Li, Ai-Yuan Cheng, Yan-Li Huo, Jie Fan, Yu-Ping Zhang, Zhi-Qin Fang, Hong-Sheng Sun, Wei Peng, Jin-Shun Zhang, Hai-Ping Wang, Bao-Jian Xue
Heart failure (HF) is characterized by cardiac dysfunction along with autonomic unbalance that is associated with increased renin-angiotensin system (RAS) activity and elevated levels of proinflammatory cytokines (PICs). Renal denervation (RD) has been shown to improve cardiac function in HF, but the protective mechanisms remain unclear. The present study tested the hypothesis that RD ameliorates isoproterenol- (ISO-) induced HF through regulation of brain RAS and PICs. Chronic ISO infusion resulted in remarked decrease in blood pressure (BP) and increase in heart rate and cardiac dysfunction, which was accompanied by increased BP variability and decreased baroreflex sensitivity and HR variability...
2016: Oxidative Medicine and Cellular Longevity
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