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https://www.readbyqxmd.com/read/29436482/the-angiotensin-type-2-receptor-in-%C3%A2-human-adrenocortical-zona-glomerulosa-and-in-aldosterone-producing-adenoma-low-expression-and-no-functional-role
#1
Paul Emmanuel Vanderriele, Brasilina Caroccia, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Francesca Torresan, Maurizio Iacobone, Thomas Unger, Gian Paolo Rossi
The angiotensin II type 2 receptor (AT2R) and the angiotensin-(1-7) receptor (MasR) play a cardiovascular protective role by counter-regulating angiotensin II type 1 receptor (AT1R)-mediated effects, but whether this involves blunting of adrenocortical hormone secretion is unknown. We investigated the presence of AT1R, AT2R and MasR in aldosterone-producing adenoma (APA), a condition featuring hyperaldosteronism, and in APA-adjacent tissue. The effect of C21, an AT2R agonist, on CYP11B1 (cortisol synthase) and CYP11B2 (aldosterone synthase) gene expression in NCI-H295R and HAC15 cell lines, and in APA and APA-adjacent tissue was also assessed using the AT1R antagonist irbesartan to ascertain the specificity of C21 effect...
February 7, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29420356/dose-effect-of-irbesartan-on-cyclooxygenase-2-and-matrix-metalloproteinase-9-expression-in-rabbit-atherosclerosis
#2
Lihua Li, Juan Li, Jing Yi, Hang Liu, Han Lei
Irbesartan has previously shown antiatherosclerotic effects on human carotid atherosclerotic plaques. Our study aimed to assess the dose-effect of irbesartan on cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in rabbit atherosclerotic aorta. New Zealand rabbits were randomly divided into 6 groups: normal control (NC), high cholesterol (HC), low-dose (10 mg·kg·day), medium-dose (20 mg·kg·d), and high-dose (30 mg·kg·d) irbesartan and celecoxib (20 mg·kg·d). Except for the NCs, rabbits were fed a HC diet for 14 weeks to induce atherosclerosis...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29399743/predicted-environmental-concentration-and-fate-of-the-top-10-most-dispensed-australian-prescription-pharmaceuticals
#3
Timothy T X Ong, Ewan W Blanch, Oliver A H Jones
A basic environmental risk assessment was carried out for the top 10 dispensed pharmaceuticals in Melbourne, Australia, in contrast to the more commonly assessed measure of the most used drugs by physical mass. This allowed for the evaluation of compounds that had not previously been the subject of risk assessment. Estimations of the possible fate and behaviour of the target pharmaceuticals in sewage treatment plants were also made. The predicted removal rates of most drugs within standard sewage treatment were expected to be low, with the exception of the statins, which had high removal rates...
February 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29378480/irbesartan-prevents-sodium-channel-remodeling-in-a-canine-model-of-atrial-fibrillation
#4
Xuewen Wang, Guangping Li
INTRODUCTION: Activation of the renin-angiotensin system (RAS) plays an important role in atrial electrical remodeling (AER). The purpose of the present study was to evaluate the effects of irbesartan on cardiac sodium current (INa) in a canine model of atrial fibrillation. MATERIALS AND METHODS: Eighteen dogs were randomized into sham, pacing or pacing+irbesartan groups ( n = 6 in each group). The dogs in the pacing and irbesartan group were paced at 500 bpm for two weeks...
January 2018: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/29368174/impact-of-drug-polymer-miscibility-on-enthalpy-relaxation-of-irbesartan-amorphous-solid-dispersions
#5
Sonu Dalsania, Jagadish Sharma, Bhushan Munjal, Arvind K Bansal
PURPOSE: Drug-polymer miscibility has been proposed to play a critical role in physical stability of amorphous solid dispersions (ASDs). The purpose of the current work was to investigate the role of drug-polymer miscibility on molecular mobility, measured as enthalpy relaxation (ER) of amorphous irbesartan (IBS) in ASDs. METHODS: Two polymers, i.e. polyvinylpyrrolidone K30 (PVP K30) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), were used to generate ASDs with 10% w/w of the polymer...
January 9, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29320191/synthesis-of-2-aminoimidazolones-and-imidazolones-by-3-2-annulation-of-azaoxyallyl-cations
#6
Maria C DiPoto, Jimmy Wu
The first examples of (3 + 2) annulations between azaoxyallyl cations and cyanamides and nitriles to give the corresponding 2-aminoimidazolones and imidazolones are reported. On the basis of the isolation of unexpected imidate products with certain substrates, it is proposed that the reaction proceeds via fast kinetic O-alkylation followed by rearrangement to the thermodynamically favored 2-aminoimidazolones and imidazolones. The method was applied to the formal synthesis of the antihypertensive drug irbesartan...
January 10, 2018: Organic Letters
https://www.readbyqxmd.com/read/29287270/sorption-of-citalopram-irbesartan-and-fexofenadine-in-soils-estimation-of-sorption-coefficients-from-soil-properties
#7
Aleš Klement, Radka Kodešová, Martina Bauerová, Oksana Golovko, Martin Kočárek, Miroslav Fér, Olga Koba, Antonín Nikodem, Roman Grabic
The sorption of 3 pharmaceuticals, which may exist in 4 different forms depending on the solution pH (irbesartan in cationic, neutral and anionic, fexofenadine in cationic, zwitter-ionic and anionic, and citalopram cationic and neutral), in seven different soils was studied. The measured sorption isotherms were described by Freundlich equations, and the sorption coefficients, KF (for the fixed n exponent for each compound), were related to the soil properties to derive relationships for estimating the sorption coefficients from the soil properties (i...
March 2018: Chemosphere
https://www.readbyqxmd.com/read/29279269/renin-angiotensin-aldosterone-system-raas-blockers-usage-among-type-ii-diabetes-mellitus-patients-a-retrospective-study
#8
Yen Ping Ng, Ganesh Pandian Balasubramanian, Yi Ping Heng, Meera Kalaiselvan, Yu Wen Teh, Kin Man Cheong, Muhammad Faiz Bin Abdul Hadi, Rosmaliza Bt Othman
AIMS: Recent data showed an alarming rise of new dialysis cases secondary to diabetic nephropathy despite the growing usage of RAAS blockers. Primary objective of this study is to explore the prevalence of RAAS blockers usage among type II diabetic patients, secondary objectives are to compare the prescribing pattern of RAAS blocker between primary and tertiary care center and to explore if the dose of RAAS blocker prescribed was at optimal dose as suggested by trials. MATERIALS AND METHODS: This is a retrospective study conducted at one public tertiary referral hospital and one public health clinic in Sungai Petani, Kedah, Malaysia...
December 21, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29276929/-choice-of-angiotensin-receptor-blocker-at-various-stages-of-the-cardiovascular-continuum
#9
V I Podzolkov, N A Dragomiretskaya
We present in this paper modern views on components, physiological and pathophysiological effects of the renin-angiotensin system, pathways of its hyperactivation at various stages of the cardiovascular continuum. Special emphasis is made on angiotensin receptor blockers (sartans). Basing on results of analysis of randomized clinical trials of these agents we have outlined clinical situations in which prescription of one or another drug from this group is preferable. For patients with multiple risk factors of cardiovascular complications preferable agent is telmisartan, for patients with nephropathy - irbesartan, for survivors of acute myocardial infarction - valsartan, while for patients with clinical signs of chronic heart failure with low ejection fraction 3 agents can be designated as preferrable - losartan, valsartan, and candesartan...
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29247285/antioxidant-based-eutectics-of-irbesartan-viable-multicomponent-forms-for-the-management-of-hypertension
#10
Jamshed Haneef, Renu Chadha
The present research work highlights the development of multicomponent solid form of the antihypertensive drug irbesartan (IRB) to improve its biopharmaceutical attributes. Mechanochemical synthesis of a new solid form of IRB with coformers having antioxidant properties (syringic acid, nicotinic acid, and ascorbic acid) resulted into three eutectic mixtures (EMs). Formation of eutectic was ascertained by differential scanning calorimetry whereas exact stoichiometry (50/50% w/w) was established by phase diagram and Tamman's triangle...
December 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29214535/simultaneous-determination-of-41-multiclass-organic-pollutants-in-environmental-waters-by-means-of-polyethersulfone-microextraction-followed-by-liquid-chromatography-tandem-mass-spectrometry
#11
Leire Mijangos, Haizea Ziarrusta, Maitane Olivares, Olatz Zuloaga, Monika Möder, Nestor Etxebarria, Ailette Prieto
A new procedure using polyethersulfone (PES) microextraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was developed in this work for the simultaneous determination of 41 multiclass priority and emerging organic pollutants including herbicides, hormones, personal care products, and pharmaceuticals, among others, in seawater, wastewater treatment plant (WWTP) effluents, and estuary samples. The optimization of the analysis included two different chromatographic columns and different variables (polarity, fragmentor voltage, collision energy, and collision cell accelerator) of the mass spectrometer...
December 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29172732/effect-of-amlodipine-efonidipine-and-trichlormethiazide-on-home-blood-pressure-and-upper-normal-microalbuminuria-assessed-by-casual-spot-urine-test-in-essential-hypertensive-patients
#12
Miki Hosaka, Ryusuke Inoue, Michihiro Satoh, Daisuke Watabe, Tomohiro Hanazawa, Takayoshi Ohkubo, Kei Asayama, Taku Obara, Yutaka Imai
The aim of this study was to assess the effects of irbesartan alone and combined with amlodipine, efonidipine, or trichlormethiazide on blood pressure (BP) and urinary albumin (UA) excretion in hypertensive patients with microalbuminuria (30≤UA/creatinine (Cr) ratio [UACR] <300 mg/g Cr) and upper-normal microalbuminuria (10≤UACR<30 mg/g Cr). This randomized controlled trial enrolled 175 newly diagnosed and untreated hypertensive patients (home systolic blood pressure [SBP]≥135 mmHg; 10≤UACR<300 mg/g Cr of casual spot urine at the first visit to clinic)...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29155324/angiotensin-receptor-blocker-irbesartan-reduces-stress-induced-intestinal-inflammation-via-at1a-signaling-and-ace2-dependent-mechanism-in-mice
#13
Maimaiti Yisireyili, Yasuhiro Uchida, Koji Yamamoto, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toyoaki Murohara, Kyosuke Takeshita
Stress is associated with pathophysiology of both irritable bowel syndrome (IBS) and hypertension. Angiotensin receptor blockers (ARB) have anti-inflammatory properties via inhibition of angiotensin II (Ang II)/Ang II type I receptor axis (AT1). Inhibition of the classical RAS pathway is also involved in upregulation of angiotensin converting enzyme-2 (ACE2), which activates the Ang-(1-7)/Mas pathway to counteract inflammatory signaling and acts as a partner of the amino acid transporter, B0AT-1, to absorb tryptophan for regulation of microbiota-gut-brain axis...
November 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29142983/efficacy-and-safety-of-sparsentan-compared-with-irbesartan-in-patients-with-primary-focal-segmental-glomerulosclerosis-randomized-controlled-trial-design-duet
#14
Radko Komers, Debbie S Gipson, Peter Nelson, Sharon Adler, Tarak Srivastava, Vimal K Derebail, Kevin E Meyers, Pablo Pergola, Meghan E MacNally, Jennifer L Hunt, Alvin Shih, Howard Trachtman
Introduction: Primary focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease. There are no US Food and Drug Administration-approved therapies for FSGS, and treatment often fails to reduce proteinuria. Endothelin is an important factor in the pathophysiology of podocyte disorders, including FSGS. Sparsentan is a first-in-class, orally active, dual-acting angiotensin receptor blocker (ARB) and highly selective endothelin Type A receptor antagonist...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29114718/ascertainment-of-self-reported-prescription-medication-use-compared-with-pharmaceutical-claims-data
#15
Danijela Gnjidic, Wei Du, Sallie-Anne Pearson, Sarah N Hilmer, Emily Banks
BACKGROUND: Evidence on the comparative validity of self-reported medication use in large-scale studies is limited. This study compared self-reported medication use of prescription-only medications to gold standard pharmaceutical claims (i.e. dispensing) data. METHODS: We selected a random sample of 500 participants from the 45 and Up Study, a large-scale Australian study, with complete ascertainment of Pharmaceutical Benefits Scheme dispensing records. Self-reported medication use was ascertained by questionnaire requesting data on medications used "for most of the last 4 weeks"...
October 11, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/29078953/the-application-of-a-novel-high-resolution-mass-spectrometry-based-analytical-strategy-to-rapid-metabolite-profiling-of-a-dual-drug-combination-in-humans
#16
Jie Xing, Meitong Zang, Huixiang Liu
Metabolite profiling of combination drugs in complex matrix is a big challenge. Development of an effective data mining technique for simultaneously extracting metabolites of one parent drug from both background matrix and combined drug-related signals could be a solution. This study presented a novel high resolution mass spectrometry (HRMS)-based data-mining strategy to fast and comprehensive metabolite identification of combination drugs in human. The model drug combination was verapamil-irbesartan (VER-IRB), which is widely used in clinic to treat hypertension...
November 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28966924/a-case-of-lipoprotein-glomerulopathy-with-apoe-chicago-and-apoe-glu3lys-treated-with-fenofibrate
#17
Hitoshi Kodera, Yasuhide Mizutani, Satoshi Sugiyama, Toshio Miyata, Takashi Ehara, Akira Matsunaga, Takao Saito
Lipoprotein glomerulopathy (LPG) is characterized by the accumulation of lipoprotein thrombi within glomerular capillaries. This rare disorder is associated with various types of mutations in the apolipoprotein E gene (apoE). Herein, we present a case of LPG with a combination of apoE Chicago (Arg147Pro) and apoE (Glu3Lys) mutations. A 51-year-old Japanese woman presented with severe (3+) proteinuria. The initial renal biopsy showed glomerular capillary dilation and occlusion with lipid granules, a specific characteristic of LPG...
May 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28951842/studies-on-jackfruit-seed-starch-as-a-novel-natural-superdisintegrant-for-the-design-and-evaluation-of-irbesartan-fast-dissolving-tablets
#18
Vidyadhara Suryadevara, Sasidhar Reddyvallam Lankapalli, Lakshmi Harika Danda, Vijetha Pendyala, Vijetha Katta
BACKGROUND: In the present investigation, an attempt was made to isolate starch from jackfruit seed powder and utilize it as a superdisintegrant to design fast dissolving tablets of irbesartan. METHODS: Starch was isolated from jackfruit seeds via aqueous and alkali extraction processes and evaluated for its physicochemical properties, for phytochemical tests, and for acute toxicity studies. Irbesartan fast dissolving formulations were prepared using the wet granulation technique...
September 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/28923834/is-chronic-dialysis-the-right-hard-renal-end-point-to-evaluate-renoprotective-drug-effects
#19
Misghina Weldegiorgis, Dick de Zeeuw, Jamie P Dwyer, Peter Mol, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVES: RRT and doubling of serum creatinine are considered the objective hard end points in nephrology intervention trials. Because both are assumed to reflect changes in the filtration capacity of the kidney, drug effects, if present, are attributed to kidney protection. However, decisions to start RRT are not only on the basis of filtration capacity of the kidney, but also on other factors. We therefore compared the time to RRT with the time to a fixed eGFR threshold and assessed the effect of the renoprotective drug irbesartan on both components...
October 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28886992/study-on-the-effect-of-irbesartan-on-atrial-fibrillation-recurrence-in-kumamoto-atrial-fibrillation-suppression-trial-silk-study
#20
Hiroshige Yamabe, Koichi Kaikita, Toshiyuki Matsumura, Atsushi Iwasa, Junjiro Koyama, Takashi Uemura, Yasuhiro Morikami, Ryusuke Tsunoda, Kenji Morihisa, Kazuteru Fujimoto, Ichiro Kajiwara, Kunihiko Matsui, Kenichi Tsujita, Hisao Ogawa
BACKGROUND: Experimental studies suggest that angiotensin II-receptor blockers can influence atrial remodeling and may prevent atrial fibrillation (AF). Therefore, we hypothesized that irbesartan may prevent the recurrence of AF following either catheter ablation or electrical cardioversion of AF. METHODS: Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto (SILK study) is a prospective, multicenter, randomized, and open-label comparative evaluation of the effects of irbesartan and amlodipine on AF recurrence in hypertensive patients with AF who are scheduled to undergo catheter ablation or electrical cardioversion of AF...
September 5, 2017: Journal of Cardiology
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