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Endocervix

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https://www.readbyqxmd.com/read/29299770/a-role-for-the-endometrial-microbiome-in-dysfunctional-menstrual-bleeding
#1
Elise S Pelzer, Dana Willner, Melissa Buttini, Flavia Huygens
This study aimed to characterise the microbial community within the endometrial cavity and endocervix in women with menorrhagia or dysmenorrhea. Paired endocervical and endometrial biopsy samples were collected from women undergoing operative hysteroscopy and/or laparoscopy. Samples were cohorted based on pathology, indications for surgery, and histological dating of the endometrium. Samples were interrogated for the presence of microbial DNA using a two-step next generation sequencing technology approach to exploit the V5-V8 regions of the 16S rRNA gene...
January 3, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29223946/-quality-of-the-exo-endocervical-sampling-in-the-prevention-of-uterine-cervix-cancer
#2
Anabela A Angeleri, Lili B Díaz, Gisela Coliva, Fernando Guerra, Luis A Palaoro, Adriana E Rocher
Cervical and vaginal cytology, Papanicolaou test (PAP), is the most effective test for screening of preneoplastic lesions, and cervical cancer prevention. Its sensitivity goes from 50 to 98%, according to different statistics, and this variation is related to the sampling procedure. A satisfactory smear should be taken from the transformation zone, the junction between endocervix and exocervix. According to Bethesda, metaplastic and/or endocervical cells should be observed under the microscope. The traditional PAP smear includes an exo-endocervical sampling using the Ayre spatula; however, only near 50% of the smears are representative of the transformation zone...
2017: Medicina
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#3
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
February 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112672/diagnosis-of-cervical-precancers-by-endocervical-curettage-at-colposcopy-of-women-with-abnormal-cervical-cytology
#4
Angela Hui-Chia Liu, Joan Walker, Julia C Gage, Michael A Gold, Rosemary Zuna, S Terence Dunn, Mark Schiffman, Nicolas Wentzensen
OBJECTIVE: To evaluate the performance of routine endocervical curettage (ECC) for diagnosing high-grade cervical intraepithelial neoplasia (CIN) 2 or worse and additional precancers not otherwise detected by ectocervical biopsies. METHODS: In a secondary analysis of the Biopsy Study, a cross-sectional study conducted between 2009 and 2012 at the University of Oklahoma Health and Sciences Center that found an incremental increase in detection of cervical precancers by multiple biopsies at colposcopy, ECC was performed in most women aged 30 years or older...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29100665/sex-steroid-receptors-prostaglandin-e2-receptors-and-cyclooxygenase-in-the-equine-cervix-during-estrus-diestrus-and-pregnancy-gene-expression-and-cellular-localization
#5
Claudia B Fernandes, Shavahn C Loux, Kirsten E Scoggin, Edward L Squires, Mats H Troedsson, Alejandro Esteller-Vico, Barry A Ball
The cervix is a dynamic structure that undergoes dramatic changes during the estrous cycle, pregnancy and parturition. It is well established that hormonal changes, including estrogens, progestogens and prostaglandins, regulate the expression of key proteins involved in cervical function. The arachidonic acid cascade is important in the remodeling and relaxation of the cervix in the days preceding parturition. Despite the complexity of this mechanism, regulation of cervical function has received little study in the mare...
October 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29053991/molecular-mechanisms-of-development-of-the-human-fetal-female-reproductive-tract
#6
Gerald R Cunha, Takeshi Kurita, Mei Cao, Joel Shen, Stanley Robboy, Laurence Baskin
Human female reproductive tract development rests mostly upon hematoxilyn and eosin stained sections despite recent advances on molecular mechanisms in mouse studies. We report application of immunohistochemical methods to explore the ontogeny of epithelial and mesenchymal differentiation markers (keratins, homobox proteins, steroid receptors), transcription factors and signaling molecules (TP63 and RUNX1) during human female reproductive tract development. Keratins 6, 7, 8, 10, 14 and 19 (KRT6, KRT7, KRT8, KRT10, KRT14, KRT19) were expressed in a temporally and spatially dynamic fashion...
July 29, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28989927/metastatic-uterine-cancer-looking-as-cervical-fibroid-in-recurrent-breast-cancer-woman-a-case-report
#7
So Young Seo, Jin Yong Shin, Yong Il Ji
Metastasis to the female genital tract from extragenital primary cancer is uncommon. In this case, a 46-year-old woman was diagnosed with invasive lobular carcinoma of the left breast in 2011. She had left breast conserving surgery, chemotherapy, radiation, and hormonal therapy (gosereline and tamoxifen). However, she developed menorrhagia after interruption of hormonal therapy and incidentally, the ultrasonogram of her pelvis showed a solid, large mass in the cervix. It looked like leiomyoma. Because of massive vaginal bleeding requiring multiple blood transfusions, she underwent total hysterectomy with bilateral salpingo-oophorectomy...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28590345/two-cases-of-epithelioid-trophoblastic-tumors-in-postmenopausal-women
#8
Adriano Rodríguez-Trujillo, María José Martínez-Serrano, Adela Saco, Aureli Torné
OBJECTIVE: Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm usually presenting in women of reproductive age, with a history of a prior gestational event. Its presentation in postmenopausal women is extremely rare. Immunohistochemical staining is a helpful aid to distinguish epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. Correct diagnosis is crucial for clinical management that can vary according to the type of gestational trophoblastic neoplasm...
November 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28571791/unus-pro-omnibus-omnes-pro-uno-a-novel-evidence-based-unifying-theory-for-the-pathogenesis-of-endometriosis
#9
Antonio Simone Laganà, Salvatore Giovanni Vitale, Francesca Maria Salmeri, Onofrio Triolo, Helena Ban Frangež, Eda Vrtačnik-Bokal, Lily Stojanovska, Vasso Apostolopoulos, Roberta Granese, Vincenza Sofo
The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a physiological process that affects 90% of women, while endometriosis occurs in only 10% of cases; it also does not explain the endometriotic foci distant from the pelvis, nor explains the cases of endometriosis in male patients. The immunological alterations of the peritoneal fluid explains the effects of disease, such as the inhibition of the physiological processes of cytolysis, but does not explain the cause...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28554747/architectural-overlap-between-benign-endocervix-and-pattern-a-endocervical-adenocarcinoma-are-all-pattern-a-tumors-invasive
#10
Gregory Douglas, Brooke E Howitt, John K Schoolmeester, Lauren Schwartz, Zuzana Kos, Shahidul Islam, Bojana Djordjevic, Carlos Parra-Herran
Studies on the pattern-based classification for invasive endocervical adenocarcinoma showed that tumors with nondestructive invasion (pattern-A) have a 0% rate of nodal metastases. Our understanding of pattern-A tumors and their distinction from in-situ adenocarcinoma requires further study. Thirteen sections diagnosed independently as pattern-A adenocarcinoma by three gynecologic pathologists, and 14 sections of benign endocervix were selected. Three additional pathologists (reviewers) evaluated a digital image from each section and classified it as pattern-A or benign based on architecture only...
March 8, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28449203/two-cases-of-adenocarcinoma-in-situ-arising-in-lobular-endocervical-glandular-hyperplasia-indicating-localization-of-mucin-on-the-cluster-surface-as-an-early-cytological-finding-of-malignant-transformation
#11
Rikiya Okuyama, Hirotsugu Hashimoto, Tamaki Miura, Masatoshi Sugita, Masakazu Arai, Hajime Tsunoda, Yuko Sasajima, Hajime Horiuchi
Lobular endocervical glandular hyperplasia (LEGH) is an endocervical glandular hyperplastic lesion containing pyloric gland-like mucin, and has recently been recognized as a precursor lesion of malignant glandular lesions of the endocervix. The pyloric gland-like mucin contained in LEGH and gastric-type adenocarcinoma is observed as golden-yellowish by Papanicolaou staining. However, to our knowledge, the chronological course of the endocervical cytology of LEGH, eventually resulting in malignancy, has never been demonstrated to date...
April 27, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28427752/spontaneously-arising-tumours-and-tumour-like-lesions-of-the-cervix-and-uterus-in-83-pet-guinea-pigs-cavia-porcellus
#12
C Laik-Schandelmaier, R Klopfleisch, S Schöniger, G Weiffenbach, M Staudacher, H Aupperle
Tumours and tumour-like lesions are rare findings in the genital system of guinea pigs. The aim of the present study was to characterize nodular lesions in the cervix and uterus of guinea pigs submitted for histopathological diagnosis. Samples from 83 pet animals were investigated. Cases included 64 surgically excised masses including complete uteri (n = 37), parts from uteri containing masses (n = 8), complete masses (n = 12) or samples from masses (n = 7) and 19 complete necropsy examinations. In 55 of the cases, only solitary changes were observed; in 28 cases two or more lesions were diagnosed...
April 17, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28406994/neisseria-gonorrhoeae-infects-the-human-endocervix-by-activating-non-muscle-myosin-ii-mediated-epithelial-exfoliation
#13
Liang-Chun Wang, Qian Yu, Vonetta Edwards, Brian Lin, Jessica Qiu, Jerrold R Turner, Daniel C Stein, Wenxia Song
Colonization and disruption of the epithelium is a major infection mechanism of mucosal pathogens. The epithelium counteracts infection by exfoliating damaged cells while maintaining the mucosal barrier function. The sexually transmitted bacterium Neisseria gonorrhoeae (GC) infects the female reproductive tract primarily from the endocervix, causing gonorrhea. However, the mechanism by which GC overcome the mucosal barrier remains elusive. Using a new human tissue model, we demonstrate that GC can penetrate into the human endocervix by inducing the exfoliation of columnar epithelial cells...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28394551/mesonephric-adenocarcinoma-of-endocervix-with-lobular-mesonephric-hyperplasia-case-report
#14
Mario Puljiz, Damir Danolić, Lucija Kostić, Ilija Alvir, Darko Tomica, Ivica Mamić, Ivana Vlastelica Munivrana, Marko Puljiz, Danko Velimir Vrdoljak, Melita Perić Balja
Mesonephric adenocarcinoma is a rare variant of cervical adenocarcinoma. We present a case of mesonephric adenocarcinoma of endocervix with cervical and vaginal lobular mesonephric hyperplasia in a 57-year-old woman. Vaginal bleeding persisting for 12 months was the only symptom. Histopathologic findings and characteristic immunophenotype are crucial for the diagnosis. The tumor was composed of papillary formation with a central fi brovascular stroma, villoglandular and densely compact tubular structures containing intraluminal eosinophilic secretion, and coated with one or more rows of cylindrical atypical epithelial cells...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28368028/tenofovir-inhibits-wound-healing-of-epithelial-cells-and-fibroblasts-from-the-upper-and-lower-human-female-reproductive-tract
#15
Marta Rodriguez-Garcia, Mickey V Patel, Zheng Shen, Jack Bodwell, Richard M Rossoll, Charles R Wira
Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating HIV-target cell recruitment. Here we determined whether Tenofovir (TFV), used vaginally in HIV prevention trials, and Tenofovir alafenamide (TAF), an improved prodrug of TFV, interfere with wound healing in the human FRT. TFV treatment of primary epithelial cells and fibroblasts from the endometrium (EM), endocervix (CX) and ectocervix (ECX) significantly delayed wound closure...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28367302/the-frequency-of-staphylococcus-aureus-isolated-from-endocervix-of-infertile-women-in-northwest-iran
#16
Mohammad Taghi Akhi, Aylin Esmailkhani, Javid Sadeghi, Behrooz Niknafs, Laya Farzadi, Aydin Akhi, Elmira Najafi Nasab
BACKGROUND: Infertility is one of the major social issues. Due to the asymptomatic cervical infection associated with Staphylococcus aureus (S. aureus), the majority of patients remain undiagnosed. The present study intended to assess the frequency of S. aureus isolated from infertile women's endocervix in northwest Iran. MATERIALS AND METHODS: In a descriptive cross sectional study, specimens were randomly collected during vagina examination using a sterile speculum and swabbing...
April 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28116194/endocervical-carcinogenesis-and-hpv-vaccination-an-occasional-circumstance-or-a-gap-in-the-chain
#17
Georgios-Marios Makris, Petros Karakitsos, Eugenia Kotsifa, Niki Margari, Nikiforita Poulakaki, Theodoros N Sergentanis, Marco-Johannes Battista, Charalampos Chrelias, Nicolaos Papantoniou
As a result of the Human Papillomavirus (HPV) vaccination program, the prevalence of precancerous dysplasia and invasive cervical cancer has substantially decreased. In this brief report, we present a case of a young patient who was diagnosed with in situ adenocarcinoma of the cervix. This 30-year-old female had completed the HPV vaccination after she became sexually active and has been undergoing annual gynecological assessments, including clinical examination and Pap test, all of which had been negative. This year, her Pap test revealed a low grade squamous intraepithelial lesion (LGSIL) and additionally a colposcopy was performed...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28086915/comparative-study-in-infertile-couples-with-and-without-chlamydia-trachomatis-genital-infection
#18
COMPARATIVE STUDY
Yuanchang Zhu, Biao Yin, Tonghua Wu, Lijun Ye, Chunmei Chen, Yong Zeng, Yaou Zhang
BACKGROUND: Chlamydia, caused by the bacterium Chlamydia trachomatis(C. trachomatis), is the most common sexually transmitted disease. The incidence is not clear due to the asymptomatic nature of early stage of infections. The incidence of Chlamydia has not been fully investigated in the Chinese Han population. Since chronic infection with can C. trachomatis can lead to infertility in males and females, it is important to determine the impact of infection on clinical outcomes. The aim of this study is to explore the epidemiology of C...
January 13, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28051087/effects-of-depot-medroxyprogesterone-acetate-on-the-immune-microenvironment-of-the-human-cervix-and-endometrium-implications-for-hiv-susceptibility
#19
K K Smith-McCune, J F Hilton, U Shanmugasundaram, J W Critchfield, R M Greenblatt, D Seidman, S Averbach, L C Giudice, B L Shacklett
Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells...
September 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/27833981/m%C3%A3-llerianosis-of-the-urinary-bladder-a-rare-case-report-and-review-of-the-literature
#20
REVIEW
Marius Stanimir, LuminiŢa Cristina ChiuŢu, Sébastien Wese, Amelia Milulescu, Răducu Nicolae Nemeş, Ovidiu Gabriel Bratu
The aim of this paper is to report a very rare case of müllerianosis (endosalpinx, endometrium, and endocervix) in a post-menopausal woman. Müllerianosis of the bladder is a very rare disease, which affects mainly the women of the reproductive age group, but with a good prognosis if the transitional bladder carcinoma is resolved. We present the case of a 64-year-old woman complaining of left lower abdomen pain, repeated lower and upper tract urinary infections, emergency urinary incontinence and hematuria...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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