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https://www.readbyqxmd.com/read/29140947/congenital-cytomegalovirus-a-european-expert-consensus-statement-on-diagnosis-and-management
#1
Suzanne E Luck, Jantien W Wieringa, Daniel Blázquez-Gamero, Philipp Henneke, Katharina Schuster, Karina Butler, Maria Grazia Capretti, Maria José Cilleruelo, Nigel Curtis, Francesca Garofoli, Paul Heath, Elias Iosifidis, Nigel Klein, Giuseppina Lombardi, Hermione Lyall, Tea Nieminen, Dasja Pajkrt, Vassiliki Papaevangelou, Klara Posfay-Barbe, Laura Puhakka, Emmanuel Roilides, Pablo Rojo, Jesús Saavedra-Lozano, Teshri Shah, Mike Sharland, Harri Saxen, Ann C T M Vossen
No abstract text is available yet for this article.
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140309/biosensors-to-diagnose-chagas-disease-a-brief-review
#2
REVIEW
María-Isabel Rocha-Gaso, Luis-Jesús Villarreal-Gómez, Denis Beyssen, Frédéric Sarry, Marco-Antonio Reyna, Carlos-Napoleón Ibarra-Cerdeña
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America's main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29140265/anti-inflammatory-potential-of-1-nitro-2-phenylethylene
#3
Michelle A Sugimoto, Márcia de Jesus Amazonas da Silva, Larissa Froede Brito, Rosivaldo Dos Santos Borges, Flávio Almeida Amaral, Ana Paula de Araujo Boleti, Maritza Echevarria Ordoñez, Jose Carlos Tavares, Lirlandia Pires Sousa, Emerson Silva Lima
Inflammation is a reaction of the host to infectious or sterile stimuli and has the physiological purpose of restoring tissue homeostasis. However, uncontrolled or unresolved inflammation can lead to tissue damage, giving rise to a plethora of chronic inflammatory diseases, including metabolic syndrome and autoimmunity pathologies with eventual loss of organ function. Beta-nitrostyrene and its derivatives are known to have several biological activities, including anti-edema, vasorelaxant, antiplatelet, anti-inflammatory, and anticancer...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29139343/mycobacterium-abscessus-a-taxonomic-puzzle
#4
Enrico Tortoli, Tomas A Kohl, Barbara A Brown-Elliott, Alberto Trovato, Sylvia Cardoso-Leão, Maria Jesus Garcia, Sruthi Vasireddy, Christine Y Turenne, David E Griffith, Julie V Philley, Stefan Niemann, Richard J Wallace, Daniela M Cirillo
No abstract text is available yet for this article.
November 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29138277/coupling-shrna-screens-with-single-cell-rna-seq-identifies-a-dual-role-for-mtor-in-reprogramming-induced-senescence
#5
Marieke Aarts, Athena Georgilis, Meryam Beniazza, Patrizia Beolchi, Ana Banito, Thomas Carroll, Marizela Kulisic, Daniel F Kaemena, Gopuraja Dharmalingam, Nadine Martin, Wolf Reik, Johannes Zuber, Keisuke Kaji, Tamir Chandra, Jesús Gil
Expression of the transcription factors OCT4, SOX2, KLF4, and cMYC (OSKM) reprograms somatic cells into induced pluripotent stem cells (iPSCs). Reprogramming is a slow and inefficient process, suggesting the presence of safeguarding mechanisms that counteract cell fate conversion. One such mechanism is senescence. To identify modulators of reprogramming-induced senescence, we performed a genome-wide shRNA screen in primary human fibroblasts expressing OSKM. In the screen, we identified novel mediators of OSKM-induced senescence and validated previously implicated genes such as CDKN1A We developed an innovative approach that integrates single-cell RNA sequencing (scRNA-seq) with the shRNA screen to investigate the mechanism of action of the identified candidates...
November 14, 2017: Genes & Development
https://www.readbyqxmd.com/read/29137892/role-of-pyrophosphate-in-vascular-calcification-in-chronic-kidney-disease
#6
Daniel Azpiazu, Sergio Gonzalo, Emilio González-Parra, Jesús Egido, Ricardo Villa-Bellosta
Vascular calcification is a pathology characterized by the deposition of calcium-phosphate in cardiovascular structures, mainly in the form of hydroxyapatite crystals, resulting in ectopic calcification. It is correlated with increased risk of cardiovascular disease and myocardial infarction in diabetic patients and in those with chronic kidney disease (CKD). Vascular smooth muscle cells are sensitive to changes in inorganic phosphate (Pi) levels. They are able to adapt and modify some of their functions and promote changes which trigger calcification...
November 11, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29137157/in-situ-synthesis-of-silver-nanoparticles-in-a-hydrogel-of-carboxymethyl-cellulose-with-phthalated-cashew-gum-as-a-promising-antibacterial-and-healing-agent
#7
Ana Karina Marques Fortes Lustosa, Antônia Carla de Jesus Oliveira, Patrick Veras Quelemes, Alexandra Plácido, Francilene Vieira da Silva, Irisdalva Sousa Oliveira, Miguel Peixoto de Almeida, Adriany das Graças Nascimento Amorim, Cristina Delerue-Matos, Rita de Cássia Meneses de Oliveira, Durcilene Alves da Silva, Peter Eaton, José Roberto de Souza de Almeida Leite
Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136907/ultrasonic-based-membrane-aided-sample-preparation-of-urine-proteomes
#8
Jemmyson Romário Jesus, Hugo M Santos, H López-Fernández, Carlos Lodeiro, Marco Aurélio Zezzi Arruda, J L Capelo
A new ultrafast ultrasonic-based method for shotgun proteomics as well as label-free protein quantification in urine samples is developed. The method first separates the urine proteins using nitrocellulose-based membranes and then proteins are in-membrane digested using trypsin. The enzymatic digestion process is accelerated from overnight to four minutes using a sonoreactor ultrasonic device. Overall, the sample treatment pipeline comprising protein separation, digestion and identification is done in just 3h...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136841/miniaturized-quechers-based-methodology-for-multiresidue-determination-of-pesticides-in-odonate-nymphs-as-ecosystem-biomonitors
#9
Florencia Jesús, Ricardo Hladki, Natalia Gérez, Natalia Besil, Silvina Niell, Grisel Fernández, Horacio Heinzen, María Verónica Cesio
The impacts of the modern, agrochemicals based agriculture that threatens the overall systems sustainability, need to be monitored and evaluated. Seeking for agroecosystems monitors, the present article focus in the occurrence and abundance of aquatic macroinvertebrates, that have been frequently used as bioindicators of water quality due to their relationship with land use. Some of these organisms are on the top of the food chain, where bioaccumulation and biomagnification processes can be observed, and they can turn into secondary pollution sources of systems and terrestrial organisms as well...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136836/detection-of-new-emerging-type-a-trichothecenes-by-untargeted-mass-spectrometry
#10
Jesús M González-Jartín, Amparo Alfonso, María J Sainz, Mercedes R Vieytes, Luis M Botana
Mycotoxins occur naturally as agricultural contaminants all over the world. The toxic effects of some of their metabolites are known and their presence regulated in food and feed. This paper describes two methods for the detection of toxins of type-A trichothecenes group, and their modified forms, using mass spectrometry. Ultra-performance liquid chromatography coupled to mass spectrometry-ion trap-time of flight (UPLC-MS-IT-TOF) was employed to characterize the fragmentation pathways of 10 type-A trichothecenes, and characteristic ions were tentatively identified in scan mode through their accurate masses...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136342/direct-intranasal-application-of-the-solid-phase-of-immunocap%C3%A2-increases-nasal-specific-immunoglobulin-e-detection-in-local-allergic-rhinitis-patients
#11
Paloma Campo, María Del Carmen Plaza-Seron, Ibon Eguiluz-Gracia, Jesús Verge, Luisa Galindo, Esther Barrionuevo, Javier Fernandez, Raquel Jurado, Cristobalina Mayorga, María José Torres, Carmen Rondón
BACKGROUND: The measurement of nasal specific IgE (NsIgE) in local allergic rhinitis (LAR) patients is challenging and shows variability. The objective of this work was to evaluate a minimally-invasive method of direct detection of NsIgE in patients with LAR to Dermatophagoides pteronyssinus (DP) using an automated immunoassay. METHODS: Fifty patients participated (LAR, n = 14; allergic rhinitis (AR), n = 20; healthy controls [HC], n = 16). Detection of NsIgE was performed by direct application of the solid phase of a commercial DP ImmunoCAP® test 24 hours after DP nasal provocation...
November 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29135988/evolution-of-acute-hepatitis-c-virus-infection-in-a-large-european-city-trends-and-new-patterns
#12
César Garriga, Sandra Manzanares-Laya, Patricia García de Olalla, Pilar Gorrindo, Sabela Lens, Ricard Solà, María Martínez-Rebollar, Montserrat Laguno, Jordi Navarro, Xavier Torras, Mercè Gurguí, María-Jesús Barberá, Josep Quer, Eva Masdeu, Pere Simón, Miriam Ros, Anna de Andrés, Joan A Caylà
The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were included. Incidence ratios (IR) were then estimated for sex and age groups. Cases were grouped between 2004-2005, 2006-2011 and 2012-2015, and their incidence rate ratios (IRR) were calculated. In addition, risk factors for acute HCV infection were identified using multinomial logistic regression for complete, available and multiple imputed data...
2017: PloS One
https://www.readbyqxmd.com/read/29135919/acoustic-sensors-based-on-amino-functionalized-nanoparticles-to-detect-volatile-organic-solvents
#13
Daniel Matatagui, Oleg Kolokoltsev, José Manuel Saniger, Isabel Gràcia, María Jesús Fernández, Jose Luis Fontecha, María Del Carmen Horrillo
Love-wave gas sensors based on surface functionalized iron oxide nanoparticles has been developed in this research. Amino-terminated iron oxide nanoparticles were deposited, by a spin coating technique, onto the surface of Love-wave sensors, as a very reproducible gas-sensing layer. The gases tested were organic solvents, such as butanol, isopropanol, toluene and xylene, for a wide and low concentration range, obtaining great responses, fast response times of a few minutes (the time at which the device produced a signal change equal to 90%), good reproducibilities, and different responses for each detected solvent...
November 14, 2017: Sensors
https://www.readbyqxmd.com/read/29135438/exposure-to-perfluoroalkyl-substances-and-metabolic-outcomes-in-pregnant-women-evidence-from-the-spanish-inma-birth-cohorts
#14
Nuria Matilla-Santander, Damaskini Valvi, Maria-Jose Lopez-Espinosa, Cyntia B Manzano-Salgado, Ferran Ballester, Jesús Ibarluzea, Loreto Santa-Marina, Thomas Schettgen, Mònica Guxens, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility. OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter)...
November 13, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29135252/neo-clerodane-diterpenoids-from-salvia-polystachya-stimulate-the-expression-of-extracellular-matrix-components-in-human-dermal-fibroblasts
#15
Elihú Bautista, Naytzé Ortiz-Pastrana, Guillermo Pastor-Palacios, Angélica Montoya-Contreras, Rubén A Toscano, Jesús Morales-Jiménez, Luis A Salazar-Olivo, Alfredo Ortega
Eleven neo-clerodane diterpenoids (1-11) including the new analogues 1, 2, and 10, and 3',5,6,7-tetrahydroxy-4'-methoxyflavone (12) were isolated from the aerial parts of Salvia polystachya. Polystachyne G (1) and 15-epi-polystachyne G (2) were isolated as an epimeric mixture, containing a 5-hydroxyfuran-2(5H)-one unit in the side chain at C-12 of the neo-clerodane framework. Polystachyne H (10) contains a 1(10),2-diene moiety and a tertiary C-4 hydroxy group. The structures of these compounds were established by analysis of their NMR spectroscopic and MS spectrometric data...
November 14, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29134648/pharmacokinetics-pharmacodynamics-and-proposed-dosing-of-the-oral-jak1-and-jak2-inhibitor-baricitinib-in-pediatric-and-young-adult-candle-and-savi-patients
#16
Hanna Kim, Kristina M Brooks, Cheng Cai Tang, Paul Wakim, Mary Blake, Stephen R Brooks, Gina A Montealegre Sanchez, Adriana A de Jesus, Yan Huang, Wanxia Li Tsai, Massimo Gadina, Apurva Prakash, Jonathan Marcus Janes, Xin Zhang, William L Macias, Parag Kumar, Raphaela Goldbach-Mansky
Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of the oral janus kinase (JAK)1/JAK2 inhibitor, baricitinib, in 18 patients with Mendelian interferonopathies who are enrolled in a compassionate use program. Patients received doses between 0.1 to 17 mg per day. Covariates of weight and renal function significantly influenced volume-of-distribution and clearance respectively. The half-life of baricitinib in patients less than 40kg was substantially shorter than in adult populations, requiring the need for dosing up to 4 times daily...
November 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29134185/infiltrative-intraocular-conjunctival-squamous-cell-carcinoma-after-local-resection-and-brachytherapy-clinical-and-pathological-findings
#17
Magnolia Trinidad Cano-Suárez, María Antonia Saornil-Álvarez, Ciro García-Álvarez, Francisco López-Lara, Jesús María Frutos-Baraja, Elena García-Lagarto
A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctival squamous cell carcinoma (CSCC). Excisional biopsy showed a well-differentiated CSCC with positive margins and the patient underwent adjuvant brachytherapy. Six weeks later, examination of the anterior segment revealed cells in the anterior chamber and a neurotrophic corneal ulcer with corneal perforation. Considering the high suspicion of intraocular invasion of CSCC, the left eye was enucleated...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29134055/influence-of-goal-contents-on-exercise-addiction-analysing-the-mediating-effect-of-passion-for-exercise
#18
Álvaro Sicilia, Manuel Alcaraz-Ibáñez, María-Jesús Lirola, Rafael Burgueño
Based on the self-determination theory (Deci and Ryan, 1985, 2000), the purpose of this study was to examine the effects of exercise goal contents on exercise addiction, taking into account the mediating effects of passion for exercise. A total of 384 university students (284 men and 100 women; Mage = 20.31, SD = 3.10) completed a questionnaire that measured exercise frequency and intensity, exercise goal contents (e.g. intrinsic: social affiliation, health management, skill development; extrinsic: image and social recognition), passion for exercise (e...
October 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29134018/a-gene-tree-test-of-the-traditional-taxonomy-of-american-deer-the-importance-of-voucher-specimens-geographic-data-and-dense-sampling
#19
Eliécer E Gutiérrez, Kristofer M Helgen, Molly M McDonough, Franziska Bauer, Melissa T R Hawkins, Luis A Escobedo-Morales, Bruce D Patterson, Jesús E Maldonado
The taxonomy of American deer has been established almost entirely on the basis of morphological data and without the use of explicit phylogenetic methods; hence, phylogenetic analyses including data for all of the currently recognized species, even if based on a single gene, might improve current understanding of their taxonomy. We tested the monophyly of the morphology-defined genera and species of New World deer (Odocoileini) with phylogenetic analyses of mitochondrial DNA sequences. This is the first such test conducted using extensive geographic and taxonomic sampling...
2017: ZooKeys
https://www.readbyqxmd.com/read/29133887/a-complementary-scale-of-biased-agonism-for-agonists-with-differing-maximal-responses
#20
Javier Burgueño, Marta Pujol, Xavier Monroy, David Roche, Maria Jose Varela, Manuel Merlos, Jesús Giraldo
Compelling data in the literature from the recent years leave no doubt about the pluridimensional nature of G protein-coupled receptor function and the fact that some ligands can couple with different efficacies to the multiple pathways that a receptor can signal through, a phenomenon most commonly known as functional selectivity or biased agonism. Nowadays, transduction coefficients (log(τ/KA)), based on the Black and Leff operational model of agonism, are widely used to calculate bias. Nevertheless, combining both affinity and efficacy in a single parameter can result in compounds showing a defined calculated bias of one pathway over other though displaying varying experimental bias preferences...
November 13, 2017: Scientific Reports
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