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https://www.readbyqxmd.com/read/27922225/study-of-the-chemical-space-of-selected-bacteriostatic-sulfonamides-from-an-information-theory-point-of-view
#1
Sheila López-Rosa, Moyocoyani Molina-Espíritu, Rodolfo O Esquivel, Catalina Soriano-Correa, Jésus S Dehesa
The relative structural location of a selected group of 27 sulfonamide-like molecules in a chemical space defined by three information theory quantities (Shannon entropy, Fisher information, and disequilibrium) is discussed. This group is composed of 15 active bacteriostatic molecules, 11 theoretically designed ones, and para-aminobenzoic acid. This endeavor allows molecules that share common chemical properties through the molecular backbone, but with significant differences in the identity of the chemical substituents, which might result in bacteriostatic activity, to be structurally classified and characterized...
December 5, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27922211/transrectal-ultrasonography-of-equine-lumbosacral-nerves-pilot-study-in-28-healthy-warmblood-horses
#2
Pablo Espinosa, Philippe Benoit, Isabel Salazar, Jesús de la Fuente, Philippe Heiles
A noninvasive method for visualizing lumbosacral nerves would be helpful for horses with suspected lumbosacral plexopathy or injury. The aim of this prospective descriptive pilot study was to characterize the ultrasonographic appearance of the lumbosacral nerves in a sample of healthy horses, and expand on the technique for image acquisition. Horses were recruited for inclusion if they were determined to be healthy and sound based on clinical and lameness evaluation. Transrectal ultrasound images of the lumbosacral nerves (L6, S1, and S2) were obtained for both sides...
December 6, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27921012/expression-of-the-gene-for-autotransporter-autb-of-neisseria-meningitidis-affects-biofilm-formation-and-epithelial-transmigration
#3
Jesús Arenas, Fernanda L Paganelli, Patricia Rodríguez-Castaño, Sara Cano-Crespo, Arie van der Ende, Jos P M van Putten, Jan Tommassen
Neisseria meningitidis is a Gram-negative bacterium that resides as a commensal in the upper respiratory tract of humans, but occasionally, it invades the host and causes sepsis and/or meningitis. The bacterium can produce eight autotransporters, seven of which have been studied to some detail. The remaining one, AutB, has not been characterized yet. Here, we show that the autB gene is broadly distributed among pathogenic Neisseria spp. The gene is intact in most meningococcal strains. However, its expression is prone to phase variation due to slipped-strand mispairing at AAGC repeats located within the DNA encoding the signal sequence and is switched off in the vast majority of these strains...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27920894/recent-advances-in-the-preparation-and-application-of-multifunctional-iron-oxide-and-liposome-based-nanosystems-for-multimodal-diagnosis-and-therapy
#4
REVIEW
Marzia Marciello, Juan Pellico, Irene Fernandez-Barahona, Fernando Herranz, Jesus Ruiz-Cabello, Marco Filice
Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920729/transcriptional-network-architecture-of-breast-cancer-molecular-subtypes
#5
Guillermo de Anda-Jáuregui, Tadeo E Velázquez-Caldelas, Jesús Espinal-Enríquez, Enrique Hernández-Lemus
Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High throughput technologies allowed the identification of intrinsic subtypes that capture transcriptional differences among tumors. A remaining question is whether said differences are associated to a particular transcriptional program which involves different connections between the same molecules. In other words, whether particular transcriptional network architectures can be linked to specific phenotypes. In this work we infer, construct and analyze transcriptional networks from whole-genome gene expression microarrays, by using an information theory approach...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27920608/checklist-of-the-continental-fishes-of-the-state-of-chiapas-mexico-and-their-distribution
#6
Ernesto Velázquez-Veláquez, Jesús Manuel López-Vila, Adán Enrique Gómez-González, Emilio Ismael Romero-Berny, Jorge Luis Lievano-Trujillo, Wilfredo A Matamoros
An updated checklist of the distribution of fishes that inhabit the continental waters of the Mexican state of Chiapas is presented. The state was compartmentalized into 12 hydrological regions for the purpose of understanding the distribution of fish fauna across a state with large physiographic variance. The ichthyofauna of Chiapas is represented by 311 species distributed in two classes, 26 orders, 73 families, and 182 genera, including 12 exotic species. The families with the highest number of species were Cichlidae, Poeciliidae, Sciaenidae, Carangidae, Ariidae, Gobiidae, and Haemulidae...
2016: ZooKeys
https://www.readbyqxmd.com/read/27919214/hydrogel-based-drug-delivery-systems-a-review-with-special-emphasis-on-challenges-associated-with-decontamination-of-hydrogels-and-biomaterials
#7
Irene Satiko Kikuchi, Raquel Galante, Kamal Dua, Daniela Dal Molim Ghisleni, Terezinha de Jesus Andreoli Pinto, Venkata Ramana Malipeddi, Rajendra Awasthi
Many researches involving the development of new techniques and biomaterials to formulate a suitable drug delivery systems and tissue engineering have been conducted. The majority of published literature from these researches emphasizes the production and materials characterization. However there is very limited information regarding their sterilization methods. The present review article has summarized various different literatures that encompasses the difficulties encountered with sterilization methods in the preparations of hydrogels for biological applications...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27918665/relationships-between-internal-and-external-match-load-indicators-in-soccer-match-officials
#8
Daniel Castillo, Matthew Weston, Shaun J McLaren, Jesús Cámara, Javier Yanci
The aims of this study were to describe the internal and external match load (ML) of refereeing activity during official matches and also to investigate the relationship among the methods of ML quantification across a competitive soccer season. A further aim was to examine the usefulness of differential perceived exertion (dRPE) as a tool for monitoring internal ML in soccer referees. Twenty field referees (FR) and 43 assistant referees (AR) participated in this study. Data were collected from 30 competitive matches (FR = 20 observations, AR = 43 observations) and included measures of internal (Edwards' heart rate derived training impulse [TRIMPEDW]), external (total distance covered [TD], distance covered at high speeds [HSR] and player load [PL]) ML, differentiated ratings of perceived respiratory [sRPEres ML] and leg muscle [sRPEmus ML] exertion)...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918574/quantitative-laser-biospeckle-method-for-the-evaluation-of-the-activity-of-trypanosoma-cruzi-using-vdrl-plates-and-digital-analysis
#9
Hilda Cristina Grassi, Lisbette C García, María Lorena Lobo-Sulbarán, Ana Velásquez, Francisco A Andrades-Grassi, Humberto Cabrera, Jesús E Andrades-Grassi, Efrén D J Andrades
In this paper we report a quantitative laser Biospeckle method using VDRL plates to monitor the activity of Trypanosoma cruzi and the calibration conditions including three image processing algorithms and three programs (ImageJ and two programs designed in this work). Benznidazole was used as a test drug. Variable volume (constant density) and variable density (constant volume) were used for the quantitative evaluation of parasite activity in calibrated wells of the VDRL plate. The desiccation process within the well was monitored as a function of volume and of the activity of the Biospeckle pattern of the parasites as well as the quantitative effect of the surface parasite quantity (proportion of the object's plane)...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27918260/factors-influencing-the-spread-of-pertussis-in-households-a-prospective-study-catalonia-and-navarre-spain-2012-to-2013
#10
Pere Godoy, Manuel García-Cenoz, Diana Toledo, Glòria Carmona, Joan A Caylà, Miquel Alsedà, Josep Àlvarez, Irene Barrabeig, Neus Camps, Pere Plans, María Company, Jesús Castilla, Maria-Rosa Sala-Farré, Carmen Muñoz-Almagro, Cristina Rius, Àngela Domínguez
We aimed to investigate transmission rates of pertussis in household contacts of cases and factors associated with transmission. A prospective epidemiological study was conducted in 2012 and 2013 to determine the incidence of pertussis among household contacts of reported cases in Catalonia and Navarre, Spain. An epidemiological survey was completed for each case and contact, who were followed for 28 days to determine the source of infection (primary case) and detect the occurrence of secondary cases. Odds ratios (ORs) were used to estimate the effectiveness of vaccination and chemoprophylaxis in preventing new cases, using the formula (1 - OR) × 100...
November 10, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27918240/circadian-rhythm-effect-on-physical-tennis-performance-in-trained-male-players
#11
Álvaro López-Samanes, Diego Moreno-Pérez, José L Maté-Muñoz, Raúl Domínguez, Jesús G Pallarés, Ricardo Mora-Rodriguez, Juan F Ortega
To determine the effect of circadian rhythm on neuromuscular responses and kinematics related to physical tennis performance, after a standardised warm-up, 13 highly competitive male tennis players were tested twice for serve velocity/accuracy (SVA), countermovement vertical jump (CMJ), isometric handgrip strength (IS), agility T-test (AGIL) and a 10-m sprint (10-m RUN). In a randomised, counter-balance order, tennis players underwent the test battery twice, either in the morning (i.e., AM; 9:00 h) and in the afternoon (i...
December 5, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27916844/effect-of-thermoultrasound-on-the-antioxidant-compounds-and-fatty-acid-profile-of-blackberry-rubus-fruticosus-spp-juice
#12
José de Jesús Manríquez-Torres, José Antonio Sánchez-Franco, Esther Ramírez-Moreno, Nelly Del Socorro Cruz-Cansino, José Alberto Ariza-Ortega, Jesús Martín Torres-Valencia
Blackberry (Rubus fruticosus spp.) fruit has high antioxidant activity due to its significant content of anthocyanins and antioxidant compounds. Among emerging technologies for food preservation, thermoultrasound is a technique that reduces microbial loads and releases compounds with antioxidant properties. The objective of this study was to determine the antioxidant content and fatty acid profile of blackberry juice subjected to thermoultrasound treatment in comparison to pasteurized juice. Blackberry juice and n-hexane extracts from a control (untreated juice), pasteurized, and thermoultrasonicated samples were evaluated for antioxidant activity, fatty acid profile, and antioxidant content...
November 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27916690/acyl-homoserine-lactone-changes-the-abundance-of-proteins-and-the-levels-of-organic-acids-associated-with-stationary-phase-in-salmonella-enteritidis
#13
Felipe Alves de Almeida, Natan de Jesus Pimentel Filho, Lanna Clícia Carrijo, Cláudia Braga Pereira Bento, Maria Cristina Baracat-Pereira, Uelinton Manoel Pinto, Leandro Licursi de Oliveira, Maria Cristina Dantas Vanetti
Quorum sensing (QS) is cell-cell communication mechanism mediated by signaling molecules known as autoinducers (AIs) that lead to differential gene expression. Salmonella is unable to synthesize the AI-1 acyl homoserine lactone (AHL), but is able to recognize AHLs produced by other microorganisms through SdiA protein. Our study aimed to evaluate the influence of AI-1 on the abundance of proteins and the levels of organic acids of Salmonella Enteritidis. The presence of N-dodecyl-homoserine lactone (C12-HSL) did not interfere on the growth or the total amount of extracted proteins of Salmonella...
December 1, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27916637/-erratum-to-%C3%A2-successful-treatment-of-aortic-dissection-in-pregnant-patient-bentall-procedure-and-hemiarch%C3%A2
#14
Luis Raul Meza-López, Luis Efren Santos-Martínez, Silvia Hernández-Meneses, Juan Ignacio Moreno-Valencia, Jesus Zaín Campos-Larios, Nielzer Armando Rodríguez-Almendros, Victor Manuel Lozano-Torres, Moisés Cuttiel Calderón-Abbo
No abstract text is available yet for this article.
December 1, 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/27915418/in-vivo-cns-infection-model-of-acanthamoeba-genotype-t4-the-early-stages-of-infection-lack-presence-of-host-inflammatory-response-and-are-a-slow-and-contact-dependent-process
#15
Maritza Omaña-Molina, Dolores Hernandez-Martinez, Raquel Sanchez-Rocha, Ulises Cardenas-Lemus, Citlaltepetl Salinas-Lara, Adolfo Rene Mendez-Cruz, Laura Colin-Barenque, Patricia Aley-Medina, Jesus Espinosa-Villanueva, Leticia Moreno-Fierros, Jacob Lorenzo-Morales
This study was developed in order to describe the early morphological events observed during the invasion of two pathogenic strains of Acanthamoeba (genotype T4); A. castellanii and A. culbertsoni, at the olfactory meatus and cerebral, pulmonary, renal, hepatic and splenic tissues levels, an in vivo invasion study. Histological and immunohistochemical description of the events at 24, 48, 72, and 96 h postintranasal inoculations of BALB/c mice was performed. A. castellanii showed a higher invasion rate than A...
December 3, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27914990/presence-of-melanopsin-in-human-crystalline-lens-epithelial-cells-and-its-role-in-melatonin-synthesis
#16
Hanan Awad Alkozi, Xiaoyu Wang, Maria Jesus Perez de Lara, Jesus Pintor
Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is considered to have light regulated tasks among other functions. In the present work, melanopsin presence in human lens epithelial cells as well as in human lens tissue is described for the first time. Moreover, studying the concentration of melatonin and its synthesising enzyme AANAT proved a clear link between melanopsin activation and the suppression of melatonin synthesis. Melanopsin sensitivity to specific wavelength (465-480 nm, blue) was confirmed after making temporal studies incubating lens epithelial cells under light, red, green, blue and total darkness for 2, 4, 8, 12 h and analysing the concentration of both melatonin and its synthesising enzyme AANAT, discovering that melatonin levels after submitting cells to total darkness are significantly higher to ones submitted to white or specifically blue light (***p < 0...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27914752/utility-of-bronchoalveolar-lavage-for-the-diagnosis-of-asbestos-related-diseases
#17
María Jesús Cruz, Victor Curull, Lara Pijuan, Daniel Álvarez-Simón, Albert Sánchez-Font, Javier de Gracia, Mario Culebras, Jaume Ferrer
INTRODUCTION: Bronchoalveolar lavage (BAL) analysis has been proposed as an objective technique for confirming asbestos exposure. However, the reliability and diagnostic yield of this procedure has not been studied in Spain. The aim of this study was to assess the usefulness of the analysis of asbestos bodies (AB) in bronchoalveolar lavage (BAL) for the diagnosis of asbestos-related diseases (ARD). METHODS: BAL samples from 72 patients (66 male, mean age 66 years) undergoing bronchoscopy were analyzed...
November 30, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27914749/-development-and-pilot-study-of-a-questionnaire-to-assess-child-and-teenager-satisfaction-with-their-stay-in-hospital
#18
Montserrat Gómez de Terreros Guardiola, José Francisco Lozano Oyola, Isabel Avilés Carvajal, Rafael Jesús Martínez Cervantes
OBJECTIVE: To develop an instrument to assess the satisfaction of children and teenagers with their stay in hospital. METHODS: A qualitative analysis of hospitalisation satisfaction dimensions based on the feedback of hospitalised children and teenagers; a content validation study by a group of experts of the items generated for the different satisfaction dimensions; and a pilot study to assess the usefulness of the questionnaire with a sample of 84 children and teenagers hospitalised in Andalusia...
November 30, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27914677/erythematous-infiltrated-plaques-as-an-onset-manifestation-of-rapidly-evolving-lymphoma
#19
María Dorado Fernández, Javier Ruiz Martínez, Francisco Pastor Quirante, Jesús Hernández-Gil Sánchez
No abstract text is available yet for this article.
November 30, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27914272/innovation-evaluation-model-for-macro-construction-sector-companies-a-study-in-spain
#20
Mikel Zubizarreta, Jesús Cuadrado, Jon Iradi, Harkaitz García, Aimar Orbe
The innovativeness of the traditional construction sector, composed of construction companies or contractors, is not one of its strong points. Likewise, its poor productivity in comparison with other sectors, such as manufacturing, has historically been criticized. Similar features are found in the Spanish traditional construction sector, which it has been described as not very innovative. However, certain characteristics of the sector may explain this behavior; the companies invest in R+D less than in other sectors and release fewer patents, so traditional innovation evaluation indicators do not reflect the true extent of its innovative activity...
November 24, 2016: Evaluation and Program Planning
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