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https://www.readbyqxmd.com/read/29356380/phenyl-boronic-acids-development-led-to-validated-leads-active-in-clinical-strains-overexpressing-kpc-2-a-step-against-bacterial-resistance
#1
Giuseppe Celenza, Mattia Vicario, Pierangelo Bellio, Linciano Pasquale, Mariagrazia Perilli, Antonio Oliver, Jesus Blazquez, Laura Cendron, Donatella Tondi
The emergence and dissemination of multi drug resistant (MDR) pathogens resistant to near all available antibiotics poses a significant threat in clinical therapy. Among them, Klebsiella pneumoniae clinical isolates overexpressing KPC-2 carbapenemase are the most worrisome, extending bacterial resistance to last resort carbapenems. In this study we investigate the molecular recognition requirements in KPC-2 active site by small phenyl boronic acid derivatives. Four new phenyl boronic acid derivatives were designed and tested vs KPC-2...
January 22, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29356271/assessment-of-the-efficacy-and-tolerance-of-an-innovative-regenerative-serum-on-cutaneous-regeneration-following-fractional-laser-procedure-using-erbium-yag
#2
Natalia Jiménez, Angela Hermosa, Laura de Miguel, Natalia Sánchez-Neila, Maria Teresa Truchuelo, Itziar Eraña, Jesus Cuevas
INTRODUCTION: Cutaneous regeneration, fractional laser, medical device, cellular proliferation cutaneous changes linked to photoaging are currently treated with physical treatments, such as fractional laser, which may induce epidermal alteration. OBJECTIVE: To determine the efficacy and safety of a regenerative serum (Matricium® , Laboratoire Bioderma, France) after laser procedure. METHODS: Prospective, double-blind, controlled, and randomized study in subjects with photoaged skin...
January 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29355521/the-dictyostelium-gsk3-kinase-glka-coordinates-signal-relay-and-chemotaxis-in-response-to-growth-conditions
#3
Jesus Lacal, Zhouxin Shen, Kimberly Baumgardner, Jing Wei, Steven P Briggs, Richard A Firtel
GSK3 plays a central role in orchestrating key biological signaling pathways, including cell migration. Here, we identify GlkA as a GSK3 family kinase with functions that overlap with and are distinct from those of GskA. We show that GlkA, as previously shown for GskA, regulates the cell's cytoskeleton through MyoII assembly and control of Ras and Rap1 function, leading to aberrant cell migration. However, there are both qualitative and quantitative differences in the regulation of Ras and Rap1 and their downstream effectors, including PKB, PKBR1, and PI3K, with glkA- cells exhibiting a more severe chemotaxis phenotype than gskA- cells...
January 16, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29355169/sex-and-gender-disparities-in-the-epidemiology-and-outcomes-of-chronic-kidney-disease
#4
REVIEW
Juan Jesus Carrero, Manfred Hecking, Nicholas C Chesnaye, Kitty J Jager
Improved understanding of sex and gender-specific differences in the aetiology, mechanisms and epidemiology of chronic kidney disease (CKD) could help nephrologists better address the needs of their patients. Population-based studies indicate that CKD epidemiology differs by sex, affecting more women than men, especially with regard to stage G3 CKD. The effects of longer life expectancy on the natural decline of glomerular filtration rate (GFR) with age, as well as potential overdiagnosis of CKD through the inappropriate use of GFR equations, might be in part responsible for the greater prevalence of CKD in women...
January 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29355117/quality-evaluation-of-official-accident-reports-conducted-by-labour-authorities-in-andalusia-spain
#5
Francisco Salguero-Caparros, Manuel Suarez-Cebador, Jesús A Carrillo-Castrillo, Juan Carlos Rubio-Romero
BACKGROUND: A public accident investigation is carried out when the consequences of the incident are significant or the accident has occurred in unusual circumstances. OBJECTIVE: We evaluated the quality of the official accident investigations being conducted by Safety Specialists of the Labour Authorities in Andalusia. METHODS: To achieve this objective, we analysed 98 occupational accident investigations conducted by the Labour Authorities in Andalusia in the last quarter of 2014...
January 19, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29353453/optimization-of-biodiesel-synthesis-by-esterification-using-a-fermented-solid-produced-by-rhizopus-microsporus-on-sugarcane-bagasse
#6
Vanderleia Botton, Leandro Piovan, Henry França Meier, David Alexander Mitchell, Jesús Cordova, Nadia Krieger
A fermented solid containing lipases was produced by solid-state fermentation of Rhizopus microsporus on sugarcane bagasse enriched with urea, soybean oil, and a mineral solution. The dry fermented solid produced using R. microsporus (RMFS) was used to catalyze the synthesis of alkyl-esters by esterification in a solvent-free system containing ethanol and oleic acid (as a model system) or a mixture of fatty acids obtained from the physical hydrolysis of soybean soapstock acid oil (FA-SSAO) in subcritical water...
January 20, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29353432/post-translational-modifications-in-tumor-biomarkers-the-next-challenge-for-aptamers
#7
Ana Díaz-Fernández, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, María Jesús Lobo-Castañón
Advances in proteomics have fueled the search for novel cancer biomarkers with higher selectivity. Differential expression of low abundant proteins has been the usual way of finding those biomarkers. The existence of a selective receptor for each biomarker is compulsory for their use in diagnostic/prognostic assays. Antibodies are the receptors of choice in most cases although aptamers are becoming familiar because of their facile and reproducible synthesis, chemical stability as well as comparable affinity and selectivity...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353373/disturbance-of-metabotropic-glutamate-receptor-mediated-long-term-depression-mglu-ltd-of-excitatory-synaptic-transmission-in-the-rat-hippocampus-after-prenatal-immune-challenge
#8
Mélanie Cavalier, Azza Ben Sedrine, Lea Thevenet, Nadine Crouzin, Janique Guiramand, Marie-Céleste de Jésus Ferreira, Catherine Cohen-Solal, Gérard Barbanel, Michel Vignes
Maternal immune challenge has proved to induce moderate to severe behavioral disabilities in the offspring. Cognitive/behavioral deficits are supported by changes in synaptic plasticity in different brain areas. We have reported previously that prenatal exposure to bacterial LPS could induce inhibition of hippocampal long-term potentiation (LTP) in the CA1 area of the juvenile/adult male offspring associated with spatial learning inabilities. Nevertheless, deficits in plasticity could be observed at earlier stages as shown by the early loss of long-term depression (LTD) in immature animals...
January 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29353300/empirical-validation-of-the-crafft-abuse-screening-test-in-a-spanish-sample
#9
Antonio Rial, Sion Kim-Harris, John R Knight, Manuel Araujo, Patricia Gómez, Teresa Braña, Jesús Varela, Sandra Golpe
The CRAFFT Substance Abuse Screening Instrument, developed by the Center for Adolescents Substance Abuse Research (CeASAR) (Knight et al., 1999), is a screening tool for high-risk alcohol and drug risk consumption designed for use with adolescents. Since its publication it has been the subject of translations and validations in different countries, populations and contexts that have demonstrated its enormous potential. However, there is still no empirical validation study that would ensure its good psychometric performance in Spain...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29352704/treatment-of-adult-chronic-indeterminate-chagas-disease-with-benznidazole-and-three-e1224-dosing-regimens-a-proof-of-concept-randomised-placebo-controlled-trial
#10
Faustino Torrico, Joaquim Gascon, Lourdes Ortiz, Cristina Alonso-Vega, María-Jesús Pinazo, Alejandro Schijman, Igor C Almeida, Fabiana Alves, Nathalie Strub-Wourgaft, Isabela Ribeiro
BACKGROUND: Chagas disease is a major neglected vector-borne disease. In this study, we investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole prodrug) regimens and benznidazole versus placebo in adult chronic indeterminate Chagas disease. METHOD: In this proof-of-concept, double-blind, randomised phase 2 clinical trial, we recruited adults (18-50 years) with confirmed diagnosis of Trypanosoma cruzi infection from two outpatient units in Bolivia...
January 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29351961/occupational-therapy-intervention-improves-glycemic-control-and-quality-of-life-among-young-adults-with-diabetes-the-resilient-empowered-active-living-with-diabetes-real-diabetes-randomized-controlled-trial
#11
Elizabeth A Pyatak, Kristine Carandang, Cheryl L P Vigen, Jeanine Blanchard, Jesus Diaz, Alyssa Concha-Chavez, Paola A Sequeira, Jamie R Wood, Robin Whittemore, Donna Spruijt-Metz, Anne L Peters
OBJECTIVE: To assess the efficacy of a manualized occupational therapy (OT) intervention (Resilient, Empowered, Active Living with Diabetes [REAL Diabetes]) to improve glycemic control and psychosocial well-being among ethnically diverse young adults with low socioeconomic status (SES) who have type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS: Eighty-one young adults (age 22.6 ± 3.5 years; hemoglobin A1c [HbA1c] = 10.8%/95 mmol/mol ± 1.9%/20.8 mmol/mol) were randomly assigned to the REAL Diabetes intervention group (IG) or an attention control group (CG) over 6 months...
January 19, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29351439/role-of-reactive-oxygen-species-and-sulfide-quinone-oxoreductase-in-hydrogen-sulfide-induced-contraction-of-rat-pulmonary-arteries
#12
Jesus Prieto-Lloret, Vladimir A Snetkov, Yasin Shaifta, Inmaculada Docio, Michelle J Connolly, Charles E Mackay, Greg A Knock, Jeremy Pt Ward, Philip I Aaronson
Application of H2S ('sulfide') elicits a complex contraction in rat pulmonary arteries (PA) comprising a small transient contraction (phase 1; Ph1) followed by relaxation and then a second, larger, and more sustained contraction (phase 2; Ph2). We investigated the mechanisms causing this response using isometric myography in rat second order PA, with Na2S as a sulfide donor. Both phases of contraction to 1000μM Na2S were attenuated by the pan-PKC inhibitor Gö6983 (3μM) and by 50μM ryanodine; the Ca2+ channel blocker nifedipine (1μM) was without effect...
December 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29351293/fibroblast-growth-factor-receptor-1-amplification-in-laryngeal-squamous-cell-carcinoma
#13
Jesus Monico, Brandon Miller, Luminita Rezeanu, Warren May, Donna C Sullivan
Fibroblast growth factor receptor 1 (FGFR1) has been noted to be amplified in a variety of squamous cell carcinomas (SCCa) of the head, neck, and lung and increased copy number (CN) is a predictor of poor outcomes. FGFR1 is a therapeutic target for lung SCCa and inhibition therapy is currently in clinical trials. Absolute quantification of FGFR1 from formalin fixed paraffin embedded (FFPE) tissue of laryngeal SCCa was examined in this retrospective study. A droplet digital polymerase chain reaction (ddPCR) was used for absolute quantitation of the FGFR1 gene CN...
2018: PloS One
https://www.readbyqxmd.com/read/29350282/neutrophil-chemotaxis
#14
REVIEW
Björn Petri, Maria-Jesús Sanz
Neutrophils are the primary cells recruited to inflamed sites during an innate immune response to tissue damage and/or infection. They are finely sensitive to inciting stimuli to reach in great numbers and within minutes areas of inflammation and tissue insult. For this effective response, they can detect extracellular chemical gradients and move towards higher concentrations, the so-called chemotaxis process or guided cell migration. This directed neutrophil recruitment is orchestrated by chemoattractants, a chemically diverse group of molecular guidance cues (e...
January 19, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29349652/social-factors-associated-with-non-initiation-and-cessation-of-predominant-breastfeeding-in-a-mother-child-cohort-in-spain
#15
Maria Villar, Loreto Santa-Marina, Mario Murcia, Pilar Amiano, Silvia Gimeno, Ferran Ballester, Jordi Julvez, Dora Romaguera, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea
Objective The aim of the study was to identify factors associated with non-initiation and cessation of predominant breastfeeding (PBF) in a mother-child cohort from Spain. Materials and Methods The analysis included 2195 mother-infant from birth to 14 months post- delivery recruited between 2004 and 2008. Maternal characteristics were collected during the pregnancy. Lactation data were obtained at 6 and 14 months after delivery. PBF was defined as intake of breast milk plus liquids like juices or water. The PBF cessation was calculated using the date that women started PBF and the date that she reported to start giving infant formula and/or food...
January 18, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29349012/arthroscopic-reduction-and-internal-fixation-of-a-rim-fracture
#16
Raul Torres-Eguía, Jesús Más Martínez, Javier Sanz-Reig
Femoroacetabular impingement is uncommonly associated to a rim fracture. Complete resection of the fragment might result in iatrogenic instability or poor femoral head coverage. In this report, we describe the step-by-step surgical technique of arthroscopic partial resection of a rim fracture, reduction and internal fixation of the remaining fragment to correct the impingement, and preserve the adequate acetabular coverage.
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349004/arthroscopic-treatment-of-a-malunion-of-a-posteromedial-tubercle-fracture-of-the-talus
#17
Jesús Más Martínez, Carmen Verdú Román, Enrique Martínez Giménez, Javier Sanz-Reig, David Bustamante Suárez de Puga, Manuel Morales Santías
Posteromedial ankle impingement is rare and uncommonly associated with a fracture. Bone resection of the fragment is the recommended treatment. In this report, we describe the step-by-step surgical technique of arthroscopic resection of a malunion of a posteromedial talus fracture to correct the impingement.
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348648/specific-cyclic-adp-ribose-phosphohydrolase-obtained-by-mutagenic-engineering-of-mn2-dependent-adp-ribose-cdp-alcohol-diphosphatase
#18
João Meireles Ribeiro, José Canales, Alicia Cabezas, Joaquim Rui Rodrigues, Rosa María Pinto, Iralis López-Villamizar, María Jesús Costas, José Carlos Cameselle
Cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency than on its major substrates. Recently, we showed that mutagenesis of human ADPRibase-Mn at Phe37, Leu196 and Cys253 alters its specificity: the best substrate of the mutant F37A + L196F + C253A is cADPR by a short difference, Cys253 mutation being essential for cADPR preference...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348408/nipbl-haploinsufficiency-reveals-a-constellation-of-transcriptome-disruptions-in-the-pluripotent-and-cardiac-states
#19
Jason A Mills, Pamela S Herrera, Maninder Kaur, Lanfranco Leo, Deborah McEldrew, Jesus A Tintos-Hernandez, Ramakrishnan Rajagopalan, Alyssa Gagne, Zhe Zhang, Xilma R Ortiz-Gonzalez, Ian D Krantz
Cornelia de Lange syndrome (CdLS) is a complex disorder with multiple structural and developmental defects caused by mutations in structural and regulatory proteins involved in the cohesin complex. NIPBL, a cohesin regulatory protein, has been identified as a critical protein responsible for the orchestration of transcriptomic regulatory networks necessary for embryonic development. Mutations in NIPBL are responsible for the majority of cases of CdLS. Through RNA-sequencing of human induced pluripotent stem cells and in vitro-derived cardiomyocytes, we identified hundreds of mRNAs, pseudogenes, and non-coding RNAs with altered expression in NIPBL+/- patient-derived cells...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348128/pevonedistat-a-first-in-class-nedd8-activating-enzyme-nae-inhibitor-combined-with-azacitidine-in-patients-with-aml
#20
Ronan T Swords, Steven Coutre, Michael B Maris, Joshua F Zeidner, James M Foran, Jose Cruz, Harry P Erba, Jesus G Berdeja, Wayne Tam, Saran Vardhanabhuti, Iwona Pawlikowska-Dobler, Hélène M Faessel, Ajeeta B Dash, Farhad Sedarati, Bruce J Dezube, Douglas V Faller, Michael R Savona
Pevonedistat (TAK-924/MLN4924) is a novel inhibitor of NEDD8-activating enzyme (NAE) with single-agent activity in relapsed/refractory acute myeloid leukemia (AML). We performed a phase 1b study (NCT01814826) of pevonedistat (PEV) with azacitidine (AZA) based on synergistic activity seen preclinically. Primary objectives included safety and tolerability, and secondary objectives included pharmacokinetics (PK) and disease response. Patients ≥60 years with treatment-naïve AML, unfit for standard induction therapy, received PEV 20 or 30 mg/m2 IV on days 1, 3, and 5, combined with fixed-dose AZA (75 mg/m2 IV/SC) on days 1-5, 8, and 9, every 28 days...
January 18, 2018: Blood
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