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https://www.readbyqxmd.com/read/28823012/ratio-of-circulating-estrogen-receptors-beta-and-alpha-er%C3%AE-er%C3%AE-indicates-endoscopic-activity-in-patients-with-crohn-s-disease
#1
Pablo M Linares, Alicia Algaba, Ana Urzainqui, Mercedes Guijarro-Rojas, Rafael González-Tajuelo, Jesús Garrido, María Chaparro, Javier P Gisbert, Fernando Bermejo, Iván Guerra, Víctor Castellano, María-Encarnación Fernández-Contreras
BACKGROUND: Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammatory response, among a variety of biological processes. Their effects are antagonistic, and the net action of estrogens may depend on their relative proportions. AIM: To determine the possible association between the balance of circulating ERβ and ERα (ERβ/ERα) and IBD risk and activity...
August 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28822856/antigen-presenting-dendritic-cells-in-atherosclerosis
#2
Jesus Gil-Pulido, Alma Zernecke
Atherosclerosis is characterized by lipid accumulation and chronic inflammation of the arterial wall, involving both innate and adaptive immune responses. Accumulation of lipid-laden macrophages is a key event in atherosclerosis. However, also other immune cells, such as dendritic cells (DC) and T cells, are found within lesions. DCs are classified as a separate lineage of mononuclear phagocytes that arise from progenitors distinct from precursors of monocytes/macrophages. Although a clear attribution of the effects of antigen-presenting cells (APCs) to monocytes/macrophages and DCs is hampered by the use of promiscuous surface markers, recent research has approached to resolve the contribution of bona fide cDCs and their subsets and of plasmacytoid-DCs (pDCs) to atherosclerosis...
August 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28822112/effectiveness-of-resistance-circuit-based-training-for-maximum-oxygen-uptake-and-upper-body-one-repetition-maximum-improvements-a-systematic-review-and-meta-analysis
#3
REVIEW
Francisco Antonio Muñoz-Martínez, Jacobo Á Rubio-Arias, Domingo Jesús Ramos-Campo, Pedro E Alcaraz
BACKGROUND: It is well known that concurrent increases in both maximal strength and aerobic capacity are associated with improvements in sports performance as well as overall health. One of the most popular training methods used for achieving these objectives is resistance circuit-based training. OBJECTIVE: The objective of the present systematic review with a meta-analysis was to evaluate published studies that have investigated the effects of resistance circuit-based training on maximum oxygen uptake and one-repetition maximum of the upper-body strength (bench press exercise) in healthy adults...
August 18, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28821874/global-methylation-correlates-with-clinical-status-in-multiple-sclerosis-patients-in-the-first-year-of-ifnbeta-treatment
#4
María Jesús Pinto-Medel, Begoña Oliver-Martos, Patricia Urbaneja-Romero, Isaac Hurtado-Guerrero, Jesús Ortega-Pinazo, Pedro Serrano-Castro, Óscar Fernández, Laura Leyva
The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis (MS) patients and healthy controls. In addition, we assessed the association of LINE-1 methylation with clinical disease activity in patients treated with IFNbeta (IFNβ). We found that individuals with high levels of LINE-1 methylation showed 6-fold increased risk of suffering MS...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821297/differential-expression-of-osteopontin-and-osteoprotegerin-mrna-in-epicardial-adipose-tissue-between-patients-with-severe-coronary-artery-disease-and-aortic-valvular-stenosis-association-with-hdl-subclasses
#5
María Luna-Luna, David Cruz-Robles, Nydia Ávila-Vanzzini, Valentín Herrera-Alarcón, Jesús Martínez-Reding, Sergio Criales-Vera, Julio Sandoval-Zárate, Jesús Vargas-Barrón, Carlos Martínez-Sánchez, Armando Roberto Tovar-Palacio, José Manuel Fragoso, Elizabeth Carreón-Torres, Gilberto Vargas-Alarcón, Óscar Pérez-Méndez
BACKGROUND: Previous studies suggest a relationship of the epicardial adipose tissue (EAT) with progression and calcification of the atherosclerotic plaque; however, it is unknown if this tissue expresses genes that may participate on these processes and if the expression of these genes is regulated by high-density lipoprotein (HDL) subclasses. METHODS: To explore this possibility, we determined the mRNA expression by qPCR of a pro-calcifying gene (osteopontin (OPN)), and two anti-calcifying genes (osteoprotegerin (OPG) and osteonectin (ON)), in biopsies of EAT obtained from 15 patients with coronary artery disease (CAD) determined by angiography, and 15 patients with diagnostic of aortic valve stenosis but without CAD as control group...
August 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28821247/a-cost-effective-approach-to-produce-15-n-labelled-amino-acids-employing-chlamydomonas-reinhardtii-cc503
#6
Jesús Nicolás Carcelén, Juan Manuel Marchante-Gayón, Pablo Rodríguez González, Luis Valledor, María Jesús Cañal, José Ignacio García Alonso
BACKGROUND: The use of enriched stable isotopes is of outstanding importance in chemical metrology as it allows the application of isotope dilution mass spectrometry (IDMS). Primary methods based on IDMS ensure the quality of the analytical measurements and traceability of the results to the international system of units. However, the synthesis of isotopically labelled molecules from enriched stable isotopes is an expensive and a difficult task. Either chemical and biochemical methods to produce labelled molecules have been proposed, but so far, few cost-effective methods have been described...
August 18, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28821149/solution-blow-spun-nanocomposites-of-poly-lactic-acid-cellulose-nanocrystals-from-eucalyptus-kraft-pulp
#7
Delne Domingos da Silva Parize, Juliano Elvis de Oliveira, Tina Williams, Delilah Wood, Roberto de Jesús Avena-Bustillos, Artur Piotr Klamczynski, Gregory Melvin Glenn, José Manoel Marconcini, Luiz Henrique Capparelli Mattoso
Cellulose nanocrystals (CNCs) were extracted from Eucalyptus kraft pulp by sulfuric acid hydrolysis, and esterified with maleic anhydride (CNCMA). The incorporation of sulfate ester groups on the cellulose surface resulted in higher stability of the nanoparticles in aqueous suspensions and lower thermal stability. Then, PLA/CNC and PLA/CNCMA nanocomposites were successfully obtained by solution blow spinning (SBS) using dimethyl carbonate (DMC) as solvent. CNC and CNCMA indicated to be acting both as nucleating agents or growth inhibitors of PLA crystal and tends to favor the formation of PLA crystals of higher stability...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821067/optimization-of-high-purity-chitin-and-chitosan-production-from-illex-argentinus-pens-by-a-combination-of-enzymatic-and-chemical-processes
#8
José Antonio Vázquez, Diana Noriega, Patricia Ramos, Jesus Valcarcel, Ramon Novoa-Carballal, Lorenzo Pastrana, Rui L Reis, Ricardo I Pérez-Martín
The present report illustrates the optimisation of the experimental conditions for the chemical and enzymatic production of chitin and chitosan from Illex argentinus pen by-products. Optima conditions for chitin isolation were established at 0.82M NaOH/36.4°C, 57.5°C/pH=9.29, 59.6°C/pH=9.30 and 49.6°C/pH=5.91 for chemical, alcalase, esperase and neutrase deproteinization, respectively. Chitin samples were subsequently deacetylated by alkaline treatment reaching the highest degrees of deacetylation (DD>93%) at 61...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820896/a-strategy-for-scaling-up-access-to-comprehensive-care-in-adults-with-chagas-disease-in-endemic-countries-the-bolivian-chagas-platform
#9
Maria-Jesus Pinazo, Jimy Pinto, Lourdes Ortiz, Jareth Sánchez, Wilson García, Ruth Saravia, Mirko-R Cortez, Silvia Moriana, Enric Grau, Daniel Lozano, Joaquim Gascon, Faustino Torrico
BACKGROUND: Bolivia has the highest prevalence of Chagas disease (CD) in the world (6.1%), with more than 607,186 people with Trypanosoma cruzi infection, most of them adults. In Bolivia CD has been declared a national priority. In 2009, the Chagas National Program (ChNP) had neither a protocol nor a clear directive for diagnosis and treatment of adults. Although programs had been implemented for congenital transmission and for acute cases, adults remained uncovered. Moreover, health professionals were not aware of treatment recommendations aimed at this population, and research on CD was limited; it was difficult to increase awareness of the disease, understand the challenges it presented, and adapt strategies to cope with it...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28820892/maternal-autoimmune-antibodies-alter-the-dendritic-arbor-and-spine-numbers-in-the-infragranular-layers-of-the-cortex
#10
Jeanelle Ariza, Jesus Hurtado, Haille Rogers, Raymond Ikeda, Michael Dill, Craig Steward, Donnay Creary, Judy Van de Water, Verónica Martínez-Cerdeño
An association between maternal IgG antibodies reactive against proteins in fetal brain and an outcome of autism in the child has been identified. Using a mouse model of prenatal intraventricular administration of autism-specific maternal IgG, we demonstrated that these antibodies produce behavioral alterations similar to those in children with ASD. We previously demonstrated that these antibodies bind to radial glial stem cells (RG) and observed an increase in the number of divisions of translocating RG in the developing cortex...
2017: PloS One
https://www.readbyqxmd.com/read/28820686/the-emergence-of-severe-fever-with-thrombocytopenia-syndrome-virus
#11
Jesus A Silvas, Patricia V Aguilar
Severe fever with thrombocytopenia syndrome (SFTS) is a newly recognized hemorrhagic fever disease found throughout Asia with a case fatality rate between 12% and 30%. Since 2009, SFTS has been reported in China throughout 14 Chinese Provinces. In addition, SFTS has been recognized in South Korea and Japan with the first confirmed cases reported in 2012. A similar disease, caused by the closely related Heartland virus, was also reported in the United States in 2009. SFTS is caused by SFTS virus, a novel tick-borne virus in the family Bunyaviridae, genus Phlebovirus...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820380/similarities-of-variant-creutzfeldt-jakob-disease-strain-in-mother-and-son-in-spain-to-uk-reference-case
#12
Abigail B Diack, Aileen Boyle, Diane Ritchie, Chris Plinston, Dorothy Kisielewski, Jesús de Pedro-Cuesta, Alberto Rábano, Robert G Will, Jean C Manson
We investigated transmission characteristics of variant Creutzfeldt-Jakob disease in a mother and son from Spain. Despite differences in patient age and disease manifestations, we found the same strain properties in these patients as in UK vCJD cases. A single strain of agent appears to be responsible for all vCJD cases to date.
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28819853/enumeration-of-circulating-tumor-cells-and-disseminated-tumor-cells-in-blood-and-bone-marrow-by-immunomagnetic-enrichment-and-flow-cytometry-ie-fc
#13
Mark Jesus M Magbanua, Tulasi I Solanki, Andrea D Ordonez, Feng Hsiao, John W Park
Enumerating circulating tumor cells (CTCs) in blood and disseminated tumor cells (DTCs) in bone marrow has shown to be clinically useful, as elevated numbers of these cells predict poor clinical outcomes. Accurate detection and quantification is, however, difficult and technically challenging because CTCs and DTCs are extremely rare. We have developed a novel quantitative detection method for enumeration of CTCs and DTCs. Our approach consists of two steps: (1) EPCAM-based immunomagnetic enrichment followed by (2) flow cytometry (IE/FC)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28819845/automated-microfluidic-filtration-and-immunocytochemistry-detection-system-for-capture-and-enumeration-of-circulating-tumor-cells-and-other-rare-cell-populations-in-blood
#14
Michael Pugia, Mark Jesus M Magbanua, John W Park
Isolation by size using a filter membrane offers an antigen-independent method for capturing rare cells present in blood of cancer patients. Multiple cell types, including circulating tumor cells (CTCs), captured on the filter membrane can be simultaneously identified via immunocytochemistry (ICC) analysis of specific cellular biomarkers. Here, we describe an automated microfluidic filtration method combined with a liquid handling system for sequential ICC assays to detect and enumerate non-hematologic rare cells in blood...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28819433/alcohol-consumption-and-lung-cancer-according-to-ile349val-polymorphism-in-adh3-gene-beyond-the-tobacco-smoking-effect
#15
Ana Fernández-Somoano, Sara M Álvarez-Avellón, Ana Souto-García, Jesús Vioque, Eva M Navarrete-Muñoz, Adonina Tardón
Objectives: Smoking is the leading cause of lung cancer. However, several studies have suggested other factors such as alcohol consumption could also play a role through polymorphisms associated with alcohol metabolism. We investigated the association between alcohol consumption and lung cancer according to the Ile349Val polymorphism in the alcohol dehydrogenase 3 ADH3 gene. Methods: We carried out a hospital-based case-control study, a total of 402 incident cases of lung cancer and 383 controls were genotyped for the Ile349Val polymorphism by polymerase chain reaction combined with restriction fragment length polymorphism...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819003/skeletal-muscle-signaling-metabolism-and-performance-during-sprint-exercise-in-severe-acute-hypoxia-after-the-ingestion-of-antioxidants
#16
David Morales-Alamo, Borja Guerra, Jesus Gustavo Ponce-Gonzalez, Amelia Guadalupe-Grau, Alfredo Santana, Marcos Martin-Rincon, Miriam Gelabert-Rebato, Joan Aureli Cadefau, Roser Cussó, Cecilia Dorado, Jose A L Calbet
The aim of this study was to determine reactive oxygen species (ROS) could play a role in blunting Thr(172)-AMPKα phosphorylation in human skeletal muscle after sprint exercise in hypoxia and to elucidate the potential signaling mechanisms responsible for this response. Nine volunteers performed a single 30s sprint (Wingate test) in two occasions while breathing hypoxic gas (PIO2=75 mmHg): one after the ingestion of placebo (P) and another following the intake of antioxidants (A) (α-lipoic acid, vitamin C, and vitamin E), with a randomized double-blind design...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28818849/egfr-and-the-risk-of-community-acquired-infections
#17
Hong Xu, Alessandro Gasparini, Junichi Ishigami, Khaled Mzayen, Guobin Su, Peter Barany, Johan Ärnlöv, Bengt Lindholm, Carl Gustaf Elinder, Kunihiro Matsushita, Juan Jesús Carrero
BACKGROUND AND OBJECTIVES: Community-acquired infections are common, contributing to adverse outcomes and increased health care costs. We hypothesized that, with lower eGFR, the incidence of community-acquired infections increases, whereas the pattern of site-specific infections varies. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 1,139,470 health care users (mean age =52±18 years old, 53% women) from the Stockholm CREAtinine Measurements Project, we quantified the associations of eGFR with the risk of infections, overall and major types, over 12 months...
August 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28818754/daily-thanatomicrobiome-changes-in-soil-as-an-approach-of-postmortem-interval-estimation-an-ecological-perspective
#18
Joe Adserias-Garriga, Marta Hernández, Narciso M Quijada, David Rodríguez Lázaro, Dawnie Steadman, Jesús Garcia-Gil
Understanding human decomposition is critical for its use in postmortem interval (PMI) estimation, having a significant impact on forensic investigations. In recognition of the need to establish the scientific basis for PMI estimation, several studies on decomposition have been carried out in the last years. The aims of the present study were: (i) to identify soil microbiota communities involved in human decomposition through high-throughput sequencing (HTS) of DNA sequences from the different bacteria, (ii) to monitor quantitatively and qualitatively the decay of such signature species, and (iii) to describe succesional changes in bacterial populations from the early putrefaction state until skeletonization...
August 7, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28818628/a-prospective-multicentre-study-of-the-epidemiology-and-outcomes-of-bloodstream-infection-in-cirrhotic-patients
#19
Michele Bartoletti, Maddalena Giannella, Russell Lewis, Paolo Caraceni, Sara Tedeschi, Mical Paul, Christoph Schramm, Tony Bruns, Manuela Merli, Nazaret Cobos-Trigueros, Elena Seminari, Pilar Retamar, Patricia Muñoz, Mario Tumbarello, Patrizia Burra, Maria Torrani Cerenzia, Bruno Barsic, Ester Calbo, Alberto Enrico Maraolo, Nicola Petrosillo, Maria Angeles Galan-Ladero, Giampiero D'Offizi, Noa Bar Sinai, Jesus Rodríguez-Baño, Gabriella Verucchi, Mauro Bernardi, Pierluigi Viale
OBJECTIVE: The aim of this study was to describe the current epidemiology of BSI in patients with cirrhosis, analyse predictors of 30-day mortality, and risk factors for antibiotic resistance. METHODS: Cirrhotic patients developing a BSI episode were prospectively included at 19 centres in five countries from September 2014 to December 2015. The discrimination of mortality risk scores for 30-day mortality were compared by area under the receiver operator-risk and Cox-regression models...
August 14, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28818612/epidemiological-and-clinical-variables-related-with-the-predominant-polarity-on-bipolar-disorder-a-systematic-review
#20
Jesús García-Jiménez, Marisol Álvarez-Fernández, Lidia Aguado-Bailón, Luis Gutiérrez-Rojas
INTRODUCTION: Current classification of bipolar disorder (BD) in type i or type ii, however useful, may be insufficient to provide relevant clinical information in some patients. As a result, complementary classifications are being proposed, like the predominant polarity (PP) based, which is defined as a clear tendency in the patient to present relapses in the manic or depressive poles. METHODS: We carried out a search in PubMed and Web of Science databases, following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses -PRISMA- guidelines, to identify studies about BD reporting PP...
August 14, 2017: Revista de Psiquiatrí́a y Salud Mental
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