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Fang Zheng, Harris Perlman, Patrick Matthys, Yurong Wen, Tony Lahoutte, Serge Muyldermans, Shemin Lu, Patrick De Baetselier, Steve Schoonooghe, Nick Devoogdt, Geert Raes
Single-photon emission computed tomography combined with micro-CT (SPECT/μCT) imaging using Nanobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such as synovial macrophages, has promising potential to visualize joint inflammation in experimental arthritis. Here, we further addressed the specificity and assessed the potential for arthritis monitoring. Signals obtained with (99m)Tc-labelled NbV4m119 Nanobody were compared in joints of wild type (WT) versus CRIg(-/-) mice with collagen-induced arthritis (CIA) or K/BxN serum transfer-induced arthritis (STIA)...
October 25, 2016: Scientific Reports
Z W Wu, F X Li, C W Huo, M Z Li, W H Wang, K X Liu
The temperature evolution of icosahedral medium-range order formed by interpenetrating icosahedra in CuZr metallic glassforming liquids was investigated via molecular dynamics simulations. Scaling analysis based on percolation theory was employed, and it is found that the size distribution of clusters formed by the central atoms of icosahedra at various temperatures follows a very good scaling law with the cluster number density scaled by S(-τ) and the cluster size S scaled by |1 - Tc/T|(-1/σ), respectively...
October 25, 2016: Scientific Reports
Shun-Jin Hu, Bing Shu, Hua Jin, Xiao-Feng Li, Jia-Rong Mao, Ke-Jun Ren, Lei Gao, Li Yang, You-Wan Wu, Yong-Jun Wang
OBJECTIVE: To evaluate the renal protective effect of Tangshenkang Granule () in a rat model of diabetic nephropathy (DN). METHODS: Forty male Sprague-Dawley rats were randomly divided into control, DN, Tangshenkang and benazepril groups. DN model was established in the rats of DN, Tangshenkang and benazepril groups. Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks, respectively...
October 24, 2016: Chinese Journal of Integrative Medicine
Ramin Heshmat, Gita Shafiee, Mostafa Qorbani, Fatemeh Azizi-Soleiman, Shirin Djalalinia, Mohammad Esmaeil Motlagh, Gelayol Ardalan, Zeinab Ahadi, Omid Safari, Saeid Safiri, Roya Kelishadi
Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study...
2016: Journal of Cardiovascular and Thoracic Research
Ardashel Latsuzbaia, Vincent W V Jaddoe, Albert Hofman, Oscar H Franco, Janine F Felix
Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied whether these variants already affect lipid concentrations in a large group of 2645 children with a median age of 6.0 years (95% range 5.7-7.3) from the population-based Generation R Study. 28 single nucleotide polymorphisms (SNPs) associated with triglycerides (TG), 39 SNPs associated with total cholesterol (TC), 28 SNPs associated with low density lipoprotein cholesterol (LDL-C), and 56 SNPs associated with high density lipoprotein cholesterol (HDL-C) were analyzed individually and combined into genetic risk scores...
October 24, 2016: Journal of Lipid Research
Shi-Mao Zhong, Yu-Hua Qin, Zuo-Cha Li, Ye-Sheng Wei
OBJECTIVE: To investigate the relationship between atrial fibrillation (AF) and serum soluble CD163. METHODS: A total of 336 patients with heart valve disease were included in this study, including 167 with AF and 169 with sinus rhythm. The clinical data were compared between the two grops, and Logistic regression analysis was used to identify the risk factors associated with AF. RESULTS: The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor (TNF), interleukin-6 (IL - 6), high-sensitivity C-reactive protein (hs-CRP) and left atrial diameter (LAD) all differed significantly between the two groups (P<0...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Chun-Li Fan, Jia Wu, Xiao-Min Bu, Shu-Jun Wan, Peng-Tao Guo, Yan-Juan Ma, Jun-Jun Wang
OBJECTIVE: To analyze serum levels of non-esterified fatty acids (NEFA) and albumin (ALB) in children with nephrotic syndrome (NS) and investigate the clinical significance of altered serum NEFA to ALB ratio in children with NS in acute and remission phases. METHODS: Serum levels of NEFA and ALB were measured in 55 NS children in acute phase, in 33 NS children in remission and in 122 healthy control children, and the ratio of NEFA to ALB was calculated. The other lipid/lipoprotein and renal function parameters were also analyzed in these children...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
M C Rusu, S Hostiuc, A D Vrapciu, L Mogoantă, V S Mănoiu, F Grigoriu
Telocytes (TCs) are morphologically defined as small-sized cells with long, thin, moniliform processes called telopodes (Tps). Numerous papers imply that TCs are a distinctive cell type, and that transmission electron microscopy (TEM) is the gold standard tool for their identification. We aimed to reproduce previous studies on myocardial TCs to check their validity. For this purpose we performed an immunohistochemical study on human cardiac samples from six autopsied donor cadavers, using antibodies against CD10, CD31, CD34, CD146, Ki67, alpha-smooth muscle actin (α-SMA), Platelet-Derived Growth Factor Receptor - alpha (PDGFRα) and laminin...
October 21, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Qingxin Chen, Taiwei Chu
As tumor markers, the radiolabeling of choline (Cho)-containing phospholipids in cellular membranes with (99m)Tc is a challenge. The conventional strategy to combine the metallic radionuclide with Cho by large ligand damages the bioactivity of Cho, resulting in low tumor-to-nontumor ratios. Pretargeting strategy based on strain-promoted cyclooctyne-azide cycloaddition (SPAAC) reaction was applied to solve this general problem. Functional click synthons were synthesized as pretargeting components: azidoethyl-choline (AECho) serves as tumor marker and azadibenzocyclooctyne (ADIBO) conjugated to bis(2-pieolyl) amine (BPA) ligand (ADIBO-BPA) as (99m)Tc(CO)3-labeling and azido-binding group...
October 12, 2016: Bioorganic & Medicinal Chemistry Letters
Jie Yang, Yonghui Lin, Xiaodan Yang, Tzi Bun Ng, Xiuyun Ye, Juan Lin
Magnetic cross-linked enzyme aggregates (M-CLEAs) were prepared for Cerrena laccase and used in antibiotic treatment. Of the seven antibiotics examined in this study, Cerrena laccase M-CLEAs were most effective in degradation of tetracycline (TC) and oxytetracycline (OTC), followed by ampicillin, sulfamethoxazole and erythromycin. The redox mediator ABTS was not able to improve efficiencies of degradation of TC and OTC. Cerrena laccase at 40U/mL eliminated 100μg/mL TC at pH 6 and 25°C in 48h in the absence of a redox mediator, with over 80% degradation occurring within the first 12h...
October 11, 2016: Journal of Hazardous Materials
Yilin Wu, Xinlin Liu, Jiuyun Cui, Minjia Meng, Jiangdong Dai, Chunxiang Li, Yongsheng Yan
Significant efforts have been focused on the functionalization and simplification of membrane-associated molecularly imprinted materials, which can rapidly recognize and separate specific compound. However, issues such as low permselectivity and unstable composite structures are restricting it from developing stage to a higher level. In this work, with the bioinspired design of polydopamine (pDA)-assisted inorganic film, we present a novel molecular imprinting strategy to integrate multilevel nanocomposites (Ag/pDA) into the porous membrane structure...
October 15, 2016: Journal of Hazardous Materials
Eva de Berranger, Sandie Balcaen, Malika Ainaoui, Caroline Bompoint, Cécile Borel, Nathalie Chevallier, Natacha de Bentzmann, Virginie Denis, Karine Kerautret, Sandrine Godin, Marie-Laure Labat, Maïna Letort-Bertrand, Sophie Porcheron, Leonardo Magro, Ibrahim Yakoub-Agha, Myriam Guiraud
In an attempt to harmonize clinical practices among French hematopoietic stem cell transplantation centers, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) held its sixth annual workshop series in September 2015 in Lille. This event brought together practitioners from across the country. Our article discusses the updates and modifications for the 2016 version of the national patient follow-up care logbook.
October 21, 2016: Bulletin du Cancer
Helmut Sinzinger, Anton Staudenherz, Paul Haber, Robert Berent
No abstract text is available yet for this article.
December 2016: Nuclear Medicine Communications
Julia Reinfelder, Torsten Kuwert, Michael Beck, James C Sanders, Philipp Ritt, Christian Schmidkonz, Peter Hennig, Olaf Prante, Michael Uder, Bernd Wullich, Peter Goebell
AIM: Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate cancers (PCs). Here, we report our first experience using the Tc-labeled PSMA inhibitor MIP-1404 (Progenics Pharmaceuticals, Inc, Tarrytown, NY) in 60 patients with biochemically recurrent PC. METHODS: Whole-body planar scintigraphy and SPECT/CT of the lower abdominal pelvic region of 60 patients with biochemical relapse of PC were analyzed retrospectively. In these subjects, an average dose of 733...
October 21, 2016: Clinical Nuclear Medicine
Joaquim Carreras, Yara Yukie Kikuti, Sílvia Beà, Masashi Miyaoka, Shinichiro Hiraiwa, Haruka Ikoma, Ryoko Nagao, David Martin-Garcia, Itziar Salaverria, Ai Sato, Ichiki Akifumi, Giovanna Roncador, Juan F Garcia, Kiyoshi Ando, Elias Campo, Naoya Nakamura
AIMS AND METHODS: We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B-cell lymphoma (DLBCL(sn) ) in a series of 240 DLBCL(all ()(NOS)()) including DLBCL(sn) training set (n=11) and validation set (n=18), and DLBCL(non-sn) (n=211). RESULTS: In the training set 82% had non-GCB phenotype and 18% were EBER(+) . The genomic profile showed gains((+)) of 1q21.3q31.2 (55%), 10q24.1 (46%), 11q14.1 (46%) and 18q12.1q23 (46%); losses((-)) of 6q26q27 (55%) and 9p21...
October 24, 2016: Histopathology
L-Z Qin, W Li, Y Huang, F Lu, S-J Li, H-Q Yang, J-W Zhang
OBJECTIVE: This study aims to investigate the expression of pentraxin3 (PTX3) in elderly patients with acute cerebral infarction (ACI) and to analyze the relationship of PTX3 with the severity and prognosis of ACI. PATIENTS AND METHODS: Between June 2014 and August 2015, 96 elderly patients with first-onset of ACI admitted to our institution were enrolled in the present study. Also, 70 healthy elderly subjects were included as controls in this study. Levels of PTX3, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, homocysteine (Hcy), fibrinogen (FIB), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined in all patients both pre-therapeutically and 30 days post-therapeutically...
October 2016: European Review for Medical and Pharmacological Sciences
W-J Guan, G-J Yang
OBJECTIVE: We investigated the significance of a change in retinol binding protein (RBP4) levels in the plasma of patients with coronary heart disease complicated with hyperlipidemia. PATIENTS AND METHODS: 66 cases of coronary heart disease (CHD) patients in Cardiovascular Department of our Hospital from December 2014 to December 2015 were selected. Based on the diagnostic criteria of hyperinsulinemia, patients were divided into a CHD Group with 35 cases and a CHD-Hyperinsulinemia Group (CHD-H group) with 31 cases...
October 2016: European Review for Medical and Pharmacological Sciences
Ezgi Yalçıntaş, Andreas C Scheinost, Xavier Gaona, Marcus Altmaier
The mechanisms for the reduction and uptake of Tc by magnetite (Fe3O4) and mackinawite (FeS) are investigated using X-ray absorption spectroscopy (XANES and EXAFS), in combination with thermodynamic calculations of the Tc/Fe systems and accurate characterization of the solution properties (pHm, pe, [Tc]). Batch sorption experiments were performed under strictly anoxic conditions using freshly prepared magnetite and mackinawite in 0.1 M NaCl solutions with varying initial Tc(vii) concentrations (2 × 10(-5) and 2 × 10(-4) M) and Tc loadings (400-900 ppm)...
October 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Amy E Felumlee, Angela J Marolf, Elissa K Randall, Annette M Bachand, Jessica M Quimby
Measurement of glomerular filtration rate (GFR) via gamma camera uptake of 99mTc-diethylenetriaminepentaacetic acid is a standard method for quantifying renal function. Aims of this retrospective, observer agreement study were to determine intra- and interobserver variation in GFR values for cats with chronic kidney disease and to determine whether renal insufficiency classification changed between observers. Guideline cut-points were established for the difference in repeated GFRs to differentiate changes caused by therapeutic effect vs...
October 23, 2016: Veterinary Radiology & Ultrasound
Mohammad Hossein Dehghan, Hossein Mirmiranpour, Sara Faghihi-Kashani, Kourosh Kabir, Mehrdad Larry, Ehsan Zayerzadeh, Salume Salehi
BACKGROUND: Curcumin (diferuloylmethane) has been associated with the inhibition of angiogenesis, as well as the prevention of cancers and inflammatory processes. The aim of this study was to assess the efficacy of curcumin in suppressing angiogenesis in the cultured endothelial cells of rat aortic rings. METHODS: Eight-week-old male Wistar rats were randomized into five groups each with a different treatment and cell culturing paradigm: controls cultured in the absence of VEGF (vascular endothelial growth factor) (C), controls cultured in the presence of VEGF (C-V), controls treated with curcumin and then cultured in media lacking VEGF (C-TC), diabetics cultured in media supplemented with VEGF (D-V) and diabetics treated with curcumin and then cultured in media supplemented with VEGF (D-V-TC)...
October 2016: Journal of Traditional and Complementary Medicine
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