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https://www.readbyqxmd.com/read/29474510/nudging-and-social-marketing-techniques-encourage-employees-to-make-healthier-food-choices-a-randomized-controlled-trial-in-30-worksite-cafeterias-in-the-netherlands
#1
Elizabeth Velema, Ellis L Vyth, Trynke Hoekstra, Ingrid H M Steenhuis
Background: Currently, many studies focus on how the environment can be changed to encourage healthier eating behavior, referred to as choice architecture or "nudging." However, to date, these strategies are not often investigated in real-life settings, such as worksite cafeterias, or are only done so on a short-term basis. Objective: The objective of this study is to examine the effects of a healthy worksite cafeteria ["worksite cafeteria 2.0" (WC 2...
February 21, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29473879/in-silico-based-repositioning-of-phosphinothricin-as-a-novel-technetium-99m-imaging-probe-with-potential-anti-cancer-activity
#2
Tamer M Sakr, Mohammed A Khedr, Hassan M Rashed, Maged E Mohamed
l-Phosphinothricin (glufosinate or 2-amino-4-((hydroxy(methyl) phosphinyl) butyric acid ammonium salt (AHPB)), which is a structural analog of glutamate, is a recognized herbicide that acts on weeds through inhibition of glutamine synthetase. Due to the structural similarity between phosphinothricin and some bisphosphonates (BPs), this study focuses on investigating the possibility of repurposing phosphinothricin as a bisphosphonate analogue, particularly in two medicine-related activities: image probing and as an anti-cancer drug...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29473842/antioxidant-activity-and-protective-effects-of-enzyme-extracted-oudemansiella-radiata-polysaccharides-on-alcohol-induced-liver-injury
#3
Xiuxiu Wang, Min Liu, Chen Zhang, Shangshang Li, Qihang Yang, Jianjun Zhang, Zhiyuan Gong, Jiandong Han, Le Jia
This work was to examine the antioxidation in vitro and hepatoprotective effects of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on alcohol-induced liver damage in mice. The antioxidant activities were determined according to the scavenging effects of En-OPS on hydroxyl, superoxide, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, and the level of reducing power. En-OPS showed hepatoprotective activities on decreasing the serum levels of aspertate aminotransferase (AST), alamine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as hepatic lipid levels of total cholesterol (TC) and triacylglycerols (TG)...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29473815/incidence-of-symptomatic-tethered-spinal-cord-in-pediatric-patients-presenting-with-neurofibromatosis-types-1-and-2
#4
Carolyn S Quinsey, Katie Krause, Lissa C Baird, Christina M Sayama, Nathan R Selden
OBJECTIVE The relationship between a tethered cord (TC) and neurofibromatosis type 1 (NF1) and NF2 is not known. The purpose of this study was to define the incidence of TC in pediatric neurosurgical patients who present with NF. METHODS The authors performed a single-institution (tertiary care pediatric hospital) 10-year retrospective analysis of patients who were diagnosed with or who underwent surgery for a TC and/or NF. Clinical and radiological characteristics were analyzed, as was histopathology. RESULTS A total of 424 patients underwent surgery for a TC during the study period, and 67 patients with NF were seen in the pediatric neurosurgery clinic...
February 23, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29473759/contribution-of-nontraditional-lipid-profiles-to-reduced-glomerular-filtration-rate-in-h-type-hypertension-population-of-rural-china
#5
Haoyu Wang, Zhao Li, Xiaofan Guo, Yintao Chen, Shuang Chen, Yichen Tian, Yingxian Sun
BACKGROUND: Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric, and blood pressure values. Reduced GFR was considered if meeting estimated GFR< 60 ml/min/1...
February 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29473304/non-enhanced-magnetic-resonance-imaging-versus-renal-scintigraphy-in-acute-pyelonephritis
#6
Jun Aoyagi, Takahiro Kanai, Jun Odaka, Takane Ito, Takashi Saito, Hiroyuki Betsui, Rieko Furukawa, Waka Nakata, Takanori Yamagata
The utility of non-enhanced magnetic resonance imaging (MRI) has not been examined extensively for diagnosing acute pyelonephritis (APN) in children. The aims of this study were to compare non-enhanced MRI with technetium-99 m dimercaptosuccinic acid (99m Tc-DMSA) renal scintigraphy in detecting APN. Six boys and one girl with temperature ≥38°C and positive urine culture received both non-enhanced MRI with whole body diffusion-weighted imaging (DWI) and99m Tc-DMSA scintigraphy ≤7 days from the fever onset...
February 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29472098/comparison-of-relative-renal-functions-calculated-with-99m-tc-dtpa-and-99m-tc-dmsa-for-kidney-patients-of-wide-age-ranges
#7
M A Momin, M N A Abdullah, M S Reza
Renal scintigraphy is an imaging method that uses small amount of radioactive materials called radiotracers, a Gamma camera and a computer to evaluate kidney functions and its anatomy. The present work reports the comparison of the relative renal functions (RRF) calculated with technetium-99m dimercaptosuccinic acid (99m Tc‑DMSA) and technetium-99m diethylenetriaminepentaacetic acid (99m Tc‑DTPA) for kidney patients of ages between 5 months and 71 years. A total of 50 patients including 29 male and 21 female has been selected and studied for renography...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472078/intercomparison-of-99m-tc-18-f-and-111-in-activity-measurements-with-radionuclide-calibrators-in-belgian-hospitals
#8
Clarita Saldarriaga Vargas, Sunay Rodríguez Pérez, Kristof Baete, Stefaan Pommé, Jan Paepen, Raf Van Ammel, Lara Struelens
This study presents current status of performance of radiopharmaceutical activity measurements using radionuclide calibrators in Belgium. An intercomparison exercise was performed among 15 hospitals to test the accuracy of99m Tc,18 F and111 In activity measurements by means of radionuclide calibrators. Four sessions were held in different geographical regions between December 2013 and February 2015. The data set includes measurements from 38 calibrators, yielding 36 calibrations for99m Tc and111 In, and 21 calibrations for18 F...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29471855/phase-based-treatment-versus-immediate-trauma-focused-treatment-in-patients-with-childhood-trauma-related-posttraumatic-stress-disorder-study-protocol-for-a-randomized-controlled-trial
#9
Noortje I van Vliet, Rafaele J C Huntjens, Maarten K van Dijk, Ad de Jongh
BACKGROUND: The treatment of posttraumatic stress disorder (PTSD) related to a history of sexual and/or physical abuse in childhood is the subject of international debate, with some favouring a phase-based approach as their preferred treatment, while others argue for immediate trauma-focused treatment. A history of (chronic) traumatisation during childhood has been linked to the development of distinct symptoms that are often labelled as symptoms of complex PTSD. Many therapists associate the presence of symptoms of complex PTSD with a less favourable treatment prognosis...
February 22, 2018: Trials
https://www.readbyqxmd.com/read/29471762/impact-of-cocaine-use-on-protease-inhibitor-associated-dyslipidemia-in-hiv-infected-adults
#10
Ji Li, Hong Lai, Shaoguang Chen, Shenghan Lai
Previous studies have demonstrated a link between protease inhibitor (PI)-based therapy and lipid dysregulation. The main objective of this study was to examine whether cocaine use may modify PI-associated dyslipidemia in adults. Between June 2003 and June 2014, 957 human immunodeficiency virus (HIV)-infected participants in Baltimore, Maryland were enrolled in a study that investigated HIV/antiretroviral therapy-associated comorbidities. Multiple linear and logistic regression models were fitted to examine the associations between PI therapy and lipid profiles for the pooled sample and cocaine use subgroups, respectively...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29471223/indirect-calculation-of-monoclonal-antibodies-in-nanoparticles-using-the-radiolabeling-process-with-technetium-99-metastable-as-primary-factor-alternative-methodology-for-the-entrapment-efficiency
#11
Edward Helal-Neto, Santiago Sánchez Cabezas, Félix Sancenón, Ramón Martínez-Máñez, Ralph Santos-Oliveira
The use of monoclonal antibodies (Mab) in the current medicine is increasing. Antibody-drug conjugates (ADCs) represents an increasingly and important modality for treating several types of cancer. In this area, the use of Mab associated with nanoparticles is a valuable strategy. However, the methodology used to calculate the Mab entrapment, efficiency and content is extremely expensive. In this study we developed and tested a novel very simple one-step methodology to calculate monoclonal antibody entrapment in mesoporous silica (with magnetic core) nanoparticles using the radiolabeling process as primary methodology...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29471087/decontamination-of-hg-ii-from-aqueous-solution-using-polyamine-co-thiourea-inarched-chitosan-gel-derivatives
#12
Wen Liang, Manlin Li, Zengqiang Zhang, Yahui Jiang, Mukesh Kumar Awasthi, Shuncheng Jiang, Ronghua Li
Ethylenediamine (EDA), triethylenetetramine (TETA) and tetraethylenepentamine (TEPA) had been successfully introduced into the structure of thiourea (TC) modified chitosan (CS) by using formaldehyde as linkage, respectively. The resulted materials, TC-CS, TC-EDA-CS, TC-TETA-CS, and TC-TEPA-CS were characterized and employed as adsorbents in batch experiment for the Hg(II) removal. We have found the modification enhanced the Hg(II) adsorption significantly in comparison with raw CS. Hg(II) adsorption amounts for all adsorbents increased gradually and reached maxima at pH ≥ 4...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29470616/automated-spect-analysis-compared-with-expert-visual-scoring-for-the-detection-of-ffr-defined-coronary-artery-disease
#13
R S Driessen, P G Raijmakers, I Danad, W J Stuijfzand, S P Schumacher, J A Leipsic, J K Min, J Knuuti, A A Lammertsma, A C van Rossum, N van Royen, S R Underwood, P Knaapen
PURPOSE: Traditionally, interpretation of myocardial perfusion imaging (MPI) is based on visual assessment. Computer-based automated analysis might be a simple alternative obviating the need for extensive reading experience. Therefore, the aim of the present study was to compare the diagnostic performance of automated analysis with that of expert visual reading for the detection of obstructive coronary artery disease (CAD). METHODS: 206 Patients (64% men, age 58...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29469964/impact-of-slco1b1-genotype-on-pediatric-simvastatin-acid-pharmacokinetics
#14
Jonathan B Wagner, Susan Abdel-Rahman, Leon Van Haandel, Andrea Gaedigk, Roger Gaedigk, Geetha Raghuveer, Ralph Kauffman, J Steven Leeder
This study investigated the impact of allelic variation in SLCO1B1, a gene encoding for the liver-specific solute carrier organic anion transporter family member 1B1 protein (SLCO1B1), on simvastatin and simvastatin acid (SVA) systemic exposure in children and adolescents. Participants (8-20 years old) with at least 1 variant SLCO1B1 c.521T>C allele (521TC, n = 15; 521CC, n = 2) and 2 wild-type alleles (521TT, n = 15) completed a single oral dose pharmacokinetic study. At equivalent doses, SVA exposure was 6...
February 22, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29467945/a-comparative-study-of-pd-l1-immunohistochemical-assays-with-four-reliable-antibodies-in-thymic-carcinoma
#15
Tadashi Sakane, Takayuki Murase, Katsuhiro Okuda, Hisashi Takino, Ayako Masaki, Risa Oda, Takuya Watanabe, Osamu Kawano, Hiroshi Haneda, Satoru Moriyama, Yushi Saito, Takeshi Yamada, Ryoichi Nakanishi, Hiroshi Inagaki
Currently, four immunohistochemical assays are registered with the US Food and Drug Administration to detect the expression of PD-L1. We investigated the PD-L1 expression in thymic carcinomas using these four diagnostic assays. The cases of 53 patients were reviewed and their specimens were subjected to four PD-L1 assays with different antibodies (SP142, SP263, 22C3, and 28-8). The PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was evaluated. In TCs, the four assays showed similar scores in each case...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467933/determinants-of-variability-of-five-programmed-death-ligand-1-immunohistochemistry-assays-in-non-small-cell-lung-cancer-samples
#16
Ross A Soo, Joey Sze Yun Lim, Bernadette Reyna Asuncion, Zul Fazreen, Maria Cynthia Herrera, Mohd Feroz Mohd Omar, Nguyen Hoang Diem Phuong, Ju Ee Seet, Benhur Amanuel, Barry Iacopetta, David Byrne, Shona Hendry, Stephen Fox, Richie Soong
Programmed death ligand-1 (PD-L1) expression as determined by immunohistochemistry (IHC) is potentially predictive of clinical outcome. The aim of this study was to assess the concordance of reported PD-L1 IHC assays and investigate factors influencing variability. Consecutive sections from 20 non-small cell lung cancers (NSCLCs) comprising resection, core biopsy, cytology and pleural fluid samples underwent IHC with 5 different antibody/autostainer combinations: 22C3/Link48, 28-8/BOND-MAX, E1L3N/BOND-MAX, SP142/BenchMark and SP263/BenchMark...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467880/the-role-of-immune-cell-subpopulations-in-the-growth-and-rejection-of-tc-1-a9-tumors-in-novel-mouse-strains-differing-in-the-h2-d-haplotype-and-nkc-domain
#17
Marie Indrová, Joanna Rossowska, Elzbieta Pajtasz-Piasecka, Romana Mikyšková, Jan Richter, Jozef Rosina, Radislav Sedlacek, Anna Fišerová
The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines (F30 ) generated by inbreeding of Balb/c and C57BL/6 strains, which were characterized by H-2Db+d-NK1.1neg (B6-neg) and H-2Db-d+NK1.1high (Balb-high) phenotypes, were used for the present study...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467790/classification-of-autism-spectrum-disorder-using-random-support-vector-machine-cluster
#18
Xia-An Bi, Yang Wang, Qing Shu, Qi Sun, Qian Xu
Autism spectrum disorder (ASD) is mainly reflected in the communication and language barriers, difficulties in social communication, and it is a kind of neurological developmental disorder. Most researches have used the machine learning method to classify patients and normal controls, among which support vector machines (SVM) are widely employed. But the classification accuracy of SVM is usually low, due to the usage of a single SVM as classifier. Thus, we used multiple SVMs to classify ASD patients and typical controls (TC)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29466564/validation-of-the-chinese-sound-test-auditory-performance-of-hearing-aid-users
#19
Yu-Chen Hung, Ya-Jung Lee, Li-Chiun Tsai
Purpose: The Chinese Sound Test (Hung, Lin, Tsai, & Lee, 2016) has been recently developed as a modified version of the Ling Six-Sound Test (Ling, 2012). By incorporating Chinese speech sounds, this test should be able to estimate whether the listener can hear across the Chinese speech spectrum. To establish the clinical validity of the test, this study examined the relationship between the aided audiometric thresholds and the distance thresholds. Method: Sixty children with bilateral hearing aids were recruited...
February 20, 2018: American Journal of Audiology
https://www.readbyqxmd.com/read/29465605/a-false-positive-i-131-finding-of-duodenum-diverticulum-in-thyroid-cancer-evaluation-by-spect-ct-a-case-report
#20
Rang Wang, Ke Zhou, Qiuping Fan, Haotian Chen, Chengzhong Fan
RATIONALE: Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. PATIENT CONCERNS: A 44-year-old woman with a papillary thyroid carcinoma for the purpose of ablation therapy after a total thyroidectomy...
February 2018: Medicine (Baltimore)
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