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https://www.readbyqxmd.com/read/29228430/mediation-of-inflammation-obesity-and-fatty-liver-disease-by-advanced-glycation-endoproducts
#1
D-D Xiong, M Zhang, N Li, J-F Gai, L Mao, M Li
OBJECTIVE: Fatty liver may induce various complications including chronic hepatitis or liver cirrhosis, and is frequently occurred in obesity individuals. Advanced glycosylation end products (AGEs) were known to play a critical role in multiple liver diseases. This study, therefore, aimed to study the effect of AGEs on obesity, related liver cirrhosis and inflammation, on an obesity fatty liver rat model. MATERIALS AND METHODS: A total of 60 Sprague Dawley (SD) rats were randomly divided into control, model and AGEs inhibitor groups (n=20 each)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228000/an-in-vivo-assessment-of-the-cholesterol-lowering-efficacy-of-lactobacillus-plantarum-ecgc-13110402-in-normal-to-mildly-hypercholesterolaemic-adults
#2
Adele Costabile, Ivan Buttarazzi, Sofia Kolida, Sara Quercia, Jessica Baldini, Jonathan R Swann, Patrizia Brigidi, Glenn R Gibson
Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries, with elevated blood cholesterol an established risk factor. Total plasma cholesterol reduction in populations suffering from primary hypercholesterolemia may lower CHD incidence. This study investigated the cholesterol reducing capacity of Lactobacillus plantarum ECGC 13110402, a strain selected for its high bile salt hydrolase activity, in 49 normal to mildly hypercholesterolaemic adults. Primary efficacy outcomes included effect on blood lipids (total cholesterol (TC), low density lipoproteins (LDL-C), high density lipoproteins (HDL-C) and triacylgycerides (TAG), inflammatory biomarkers and occurrence/severity of gastrointestinal side effects to establish safety and tolerance of the intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29227169/descriptive-study-of-the-relationship-between-the-subclinical-carotid-disease-and-biomarkers-carotid-femoral-pulse-wave-velocity-in-patients-with-hypertension
#3
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Carotid intima-media thickness (cIMT) is a significant early prediction signal for preclinical atherosclerosis. Plasma homocysteine (Hcy) level is an independent risk factor for cardiovascular diseases. Pulse wave velocity (PWV), an index of arterial stiffness (AS), has showed its value in the evaluation of AS in vascular-related diseases. The data regarding the relationships between cIMT and other indices of vascular damage are limited and partly controversial. We aim to investigate the relationships between cIMT and other indices of vascular damage such as Hcy and carotid femoral PWV (CF-PWV)...
December 11, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29227107/o-w-emulsions-stabilized-by-acylglutamic-acid-alkylamine-complexes-as-noncovalent-type-double-chain-amphiphiles
#4
Toru Tojinbara, Masaaki Akamatsu, Kenichi Sakai, Hideki Sakai
We have studied the preparation and stabilization mechanism of oil-in-water (O/W) type emulsions in the presence of amphiphilic 1:1 stoichiometric complexes of acylglutamic acids (CnGlu) with tertiary alkylamines (CnDMA). Relatively stable emulsions were obtained when C16Glu-C16DMA (or C18Glu-C18DMA), hexadecane, and water were homogenized at 80 °C and then stored at room temperature. The gel-liquid crystal phase transition temperature (Tc) of C16Glu-C16DMA and C18Glu-C18DMA dispersed in water was determined to be ca...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29226948/mir-182-5p-inhibited-oxidative-stress-and-apoptosis-triggered-by-oxidized-low-density-lipoprotein-via-targeting-toll-like-receptor-4
#5
Song-Bai Qin, Da-Yan Peng, Yan Shi, Zun-Ping Ke
MicroRNAs (miRNAs) exhibit various roles in multiple biological processes and abnormal expression of miR-182-5p has been involved in many diseases. However, the role miR-182-5p in Atherosclerosis (AS) remains poorly understood. In our current investigation, an AS model was established by using oxidized low-density lipoprotein (ox-LDL) in RAW264.7 cells. miR-182-5p was markedly decreased in AS model dose-dependently and time-dependently. Additionally, CD36, oil-red staining levels, TC and TG were inhibited by miR-182-5p mimics, meanwhile ROS levels, MDA and cell apoptosis were also restrained with an enhancement of SOD activity...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226217/lipid-profile-in-tuberculosis-patients-with-and-without-human-immunodeficiency-virus-infection
#6
Gebremedhin Gebremicael, Yemane Amare, Feyissa Challa, Atsbeha Gebreegziabxier, Girmay Medhin, Mistire Wolde, Desta Kassa
Background: Understanding whether the preceding low lipid profile leads to active tuberculosis (TB) or active TB leads to low lipid profile is crucial. Methods: Lipid profile concentrations were determined from 159 study participants composed of 93 active TB patients [44 HIV coinfected (HIV+TB+) and 49 HIV negative (HIV-TB+)], 41 tuberculin skin test (TST) positive cases [17 HIV coinfected (HIV+TST+) and 24 HIV negative (HIV-TST+)], and 25 healthy controls (HIV-TST-)...
2017: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29225964/chosen-vascular-risk-markers-in-pseudoexfoliation-syndrome-an-age-related-disorder
#7
Hanna Lesiewska, Agnieszka Łukaszewska-Smyk, Grażyna Odrowąż-Sypniewska, Magdalena Krintus, Aneta Mańkowska-Cyl, Grażyna Malukiewicz
Purpose: To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods: 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C indexes were assessed. Results: There were no significant differences in concentration of lipids and values of TC/HDL-C, TG/HDL-C, and non-HDL-C between PEX and control groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29225111/liraglutide-regulates-the-viability-of-pancreatic-%C3%AE-cells-and-pancreatic-%C3%AE-cells-through-camp-pka-signal-pathway
#8
Xuejuan Xu, Jinsong Chen, Lidong Hu, Ming Liang, Xiaozhou Wang, Si Feng, Jie Shen, Xiaojun Luan
AIMS: As a glucagon-like peptide-1 receptor agonist, liraglutide could effectively increase insulin secretion from pancreatic β-cells and suppress glucagon secretion from pancreatic α-cells in the treatment of hyperglycemia in type 2 diabetes patients. However, the mechanisms for the different regulation of pancreatic α-cells and β-cells are still unclear. In this study, we mainly explored the different effects of liraglutide on mouse pancreatic α-cell line and β-cell line in vitro...
December 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29224910/regulation-of-sirt3-foxo1-signaling-pathway-in-rats-with-non-alcoholic-steatohepatitis-by-salvianolic-acid-b
#9
Yingchun Wang, Juan Chen, Weizong Kong, Ruiping Zhu, Kai Liang, Quanxiang Kan, Yanhong Lou, Xiangyu Liu
AIMS: To explore the effect of salvianolic acid B (Sal B) on regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis (NASH). METHODS: Sixty Sprague Dawley (SD) rats were randomly divided into control, model and treatment groups. After 12 weeks of successful model establishment with high fat diet, treatment group was given Sal B by intragastric administration. After 12 weeks of treatment, rats were sacrificed and livers were taken to test indicators such as liver index, TG, TC, ALT, AST, reactive oxygen species (ROS) by DCFH-DA probe, SOD2 activity by WST-8 test...
December 7, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29224024/association-of-the-tg-hdl-c-and-non-hdl-c-hdl-c-ratios-with-chronic-kidney-disease-in-an-adult-chinese-population
#10
Jia Wen, Yiyin Chen, Yun Huang, Yao Lu, Xing Liu, Honghao Zhou, Hong Yuan
BACKGROUND/AIMS: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. METHODS: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29223854/baicalein-improves-liver-inflammation-in-diabetic-db-db-mice-by-regulating-hmgb1-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#11
Huafeng Yin, Lihao Huang, Ting Ouyang, Lvyi Chen
The current study was designed to investigate the hepatoprotective effects and possible mechanisms of Baicalein (BA) on the diabetic liver injury in vivo and in vitro. The results exhibited that BA significantly restored the blood glucose in oral glucose tolerance test (OGTT) and inhibited the levels of insulin, alanine aminotransferase (ALT), aspartate aminotransaminase (AST), total cholesterol (TC) and triglyceride (TG) in C57BL/KsJ-db/db mice. Moreover, BA strikingly attenuated the extent of steatosis in the liver tissues of diabetic mice...
December 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29223817/elevated-inflammatory-lp-pla2-and-il-6-link-e-waste-pb-toxicity-to-cardiovascular-risk-factors-in-preschool-children
#12
Xueling Lu, Xijin Xu, Yu Zhang, Yuling Zhang, Chenyang Wang, Xia Huo
Cardiovascular toxicity of lead (Pb) manifests primarily as an effect on blood pressure and eventual increased risk of atherosclerosis and cardiovascular events. Therefore, we investigated vascular inflammatory biomarkers and cardiovascular effects of Pb-exposed children. A total of 590 children (3-7 years old) were recruited from Guiyu (n = 337), an electronic waste (e-waste)-exposed group, and Haojiang (n = 253), a reference group, from November to December 2016. We measured child blood Pb levels (BPbs), and systolic and diastolic blood pressure...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29223765/prognostic-role-of-serum-total-cholesterol-and-high-density-lipoprotein-cholesterol-in-cancer-survivors-a-systematic-review-and-meta-analysis
#13
REVIEW
Pingting Zhou, Bo Li, Bin Liu, Tianrui Chen, Jianru Xiao
BACKGROUND: The alterations of lipid profile in cancer has been reported to be associated with cancer development. However, the prognostic value of serum lipid markers level in cancer is currently under debate. Here we performed a meta-analysis to investigate the prognostic significance of serum blood total cholesterol (TC), Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cancer. METHODS: We systematically searched in PubMed and EMBASE for follow-up studies to evaluate the association between blood TC, TG, HDL-C, LDL-C and overall survival (OS) or disease-free survival (DFS) in patients with cancer...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29222903/vitamin-d-status-and-cardiometabolic-risk-factors-in-young-adults-in-hong-kong-associations-and-implications
#14
Erica Wei-Lan Wang, Marco Yiu-Chung Pang, Parco Ming-Fai Siu, Claudia Kam-Yuk Lai, Jean Woo, Andrew R Collins, Iris Ff Benzie
BACKGROUND AND OBJECTIVES: Vitamin D deficiency is reportedly common, but we lack data from young adults. Such data are of interest because epidemiological data support vitamin D as a possible risk modulator for diabetes and cardiovascular ('cardiometabolic') disease. Our objectives were to assess vitamin D status (as plasma 25(OH)D concentration) and investigate associations between this and biomarkers of cardiometabolic disease risk in a group of still-healthy young adults in Hong Kong...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222656/changes-to-tetracyclines-and-tetracycline-resistance-genes-in-arable-soils-after-single-and-multiple-applications-of-manure-containing-tetracyclines
#15
Huicong Yan, Kun Zhang, Jiali Shentu, Dongsheng Shen, Na Li, Meizhen Wang
The influence of manure containing tetracyclines (TCs) on the prevalence of antibiotic resistance genes in soils remains poorly understood. Here, three different TCs (oxytetracycline (OTC), tetracycline (TC), and chlortetracycline (CTC)) were mixed respectively with unpolluted manure to fertilize arable soil. The soil received either a single application of 0 μg kg-1, 300 μg kg-1 (TC and CTC), or 700 μg kg-1 (OTC) or multiple applications every 14 days for 140 days. Four tetracycline resistance genes (TRGs), including tet(A), tet(L), tet(M), and tet(Q), were monitored...
December 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29221206/single-nucleotide-polymorphisms-rs701848-and-rs2735343-in-pten-increases-cancer-risks-in-an-asian-population
#16
Dan-Dan Song, Qian Zhang, Jing-Hua Li, Rui-Min Hao, Ying Ma, Ping-Yu Wang, Shu-Yang Xie
We performed this meta-analysis to analyze the cancer risk to individuals carrying the rs701848 and rs2735343 single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) gene. We searched the PubMed, EMBASE, Cochrane library and the national knowledge infrastructure of China (CNKI) databases and identified 18 eligible case-control studies with 5458 cases and 6003 controls for rs701848 as well as 5490 cases and 6209 controls for rs2735343. Our analyses demonstrated that cancer risk was associated with rs701848 in the recessive model (CC vs...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220714/mapping-of-radiation-anomalies-using-uav-mini-airborne-gamma-ray-spectrometry
#17
Ondřej Šálek, Milan Matolín, Lubomír Gryc
Localization of size-limited gamma-ray anomalies plays a fundamental role in uranium prospecting and environmental studies. Possibilities of a newly developed mini-airborne gamma-ray spectrometric equipment were tested on a uranium anomaly near the village of Třebsko, Czech Republic. The measurement equipment was based on a scintillation gamma-ray spectrometer specially developed for unmanned aerial vehicles (UAV) mounted on powerful hexacopter. The gamma-ray spectrometer has two 103 cm3 BGO scintillation detectors of relatively high sensitivity...
December 5, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29218950/-meta-analysis-of-yiqi-huoxue-method-in-treating-idiopathic-membranous-nephropathy
#18
Qi-Yan Zheng, Lu-Ying Sun, Hua-Nan Jin, Qian Zhou, Wen Zhang, Ya-Hui Wang
The incidence of idiopathic membranous nephropathy (IMN) is increasing year by year, and the clinical research on Chinese medicine treatment of INM is also growing. This study aims to evaluate the efficiency and safety of Yiqi Huoxue method for IMN. Data sources used were from PubMed, EMbase, the Cochrane Library, CBM, CNKI, Wanfang and VIP database. Two researchers independently screened the literature and extracted data. RevMan 5.3 software was used for Meta analysis, and the evidences were graded for the outcomes according to GRADE system by using GRADEprofiler 3...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29217942/the-association-between-fruit-and-vegetable-intake-and-liver-enzymes-aspartate-and-alanine-transaminases-in-tehran-iran
#19
Mehdi Mollahosseini, Elnaz Daneshzad, Mohammad Hossein Rahimi, Mir Saeed Yekaninejad, Zhila Maghbooli, Khadijeh Mirzaei
Background: Intake of fiber and antioxidants and following hypocaloric diets has beneficial effects on reduction of the liver enzymes. Fruits and vegetables are low in calorie and rich in fiber and antioxidants. There are few studies about special dietary effects on liver function. The aim of this study was to evaluate the association between fruit and vegetables intake and liver function enzymes. Methods: This cross-sectional study was conducted on 265 Tehrani healthy adults...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217719/can-traditional-risk-factors-explain-the-higher-risk-of-cardiovascular-disease-in-south-asians-compared-to-europeans-in-norway-and-new-zealand-two-cohort-studies
#20
Kjersti S Rabanal, Haakon E Meyer, Grethe S Tell, Jannicke Igland, Romana Pylypchuk, Suneela Mehta, Bernadette Kumar, Anne Karen Jenum, Randi M Selmer, Rod Jackson
OBJECTIVES: The objective was to prospectively examine potential differences in the risk of first cardiovascular disease (CVD) events between South Asians and Europeans living in Norway and New Zealand, and to investigate whether traditional risk factors could explain any differences. METHODS: We included participants (30-74 years) without prior CVD in a Norwegian (n=16 606) and a New Zealand (n=129 449) cohort. Ethnicity and cardiovascular risk factor information was linked with hospital registry data and cause of death registries to identify subsequent CVD events...
December 6, 2017: BMJ Open
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