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https://www.readbyqxmd.com/read/29453774/hobnail-retiform-dabska-hemangioendothelioma-located-in-jejunum
#1
Yuxin Wang, Huan Han, Yiqi Du
A 27-year-old man referred to our department with a 1-month history of intermittent melena and dizziness. Gastroscopy and colonoscopy did not identify the site of bleeding. Laboratory data showed hemoglobin 6.6g/dL. Video capsule endoscopy (CE, Anhon,China) and antegrade double-ballon enteroscopy (DBE, EN450P5, Fujinon, Japan) were carried out and a space occupying lesion in the proximal jejunum was identified (Fig.1). Ink tattooing via DBE was performed to mark the site of the tumor.Then the patient underwent jejunectomy...
February 17, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29452318/bone-metabolic-markers-in-the-clinical-assessment-of-patients-with-superior-semicircular-canal-dehiscence-treated-with-middle-fossa-craniotomy
#2
Thien Nguyen, Carlito Lagman, John P Sheppard, Courtney Duong, Vera Ong, Jessica Poon, Yasmine Alkhalid, Daniel Azzam, Prasanth Romiyo, Giyarpuram N Prashant, Quinton Gopen, Isaac Yang
BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We aim to investigate the relationships between serum calcium, 25-hydroxyvitamin D, and thyroid stimulating hormone levels, and symptoms in adult patients with SSCD treated through a middle fossa craniotomy. METHODS: Patient demographics and clinical parameters were collected...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29450890/efficacy-and-safety-of-eslicarbazepine-acetate-monotherapy-in-patients-converting-from-carbamazepine
#3
Ladislav Pazdera, Michael R Sperling, Jay H Harvey, Maria C Sam, Laura A Strom, David Blum, Todd Grinnell, Hailong Cheng
OBJECTIVE: To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when converting to eslicarbazepine acetate (ESL), using data pooled from 2 controlled conversion-to-ESL monotherapy trials (studies: 093-045, 093-046). METHODS: Adults with treatment-resistant focal (partial-onset) seizures were randomized 2:1 to ESL 1600 or 1200 mg once daily...
February 16, 2018: Epilepsia
https://www.readbyqxmd.com/read/29449770/adverse-events-following-cervical-manipulative-therapy-consensus-on-classification-among-dutch-medical-specialists-manual-therapists-and-patients
#4
Hendrikus A Kranenburg, Sandra E Lakke, Maarten A Schmitt, Cees P Van der Schans
Objectives: To obtain consensus-based agreement on a classification system of adverse events (AE) following cervical spinal manipulation. The classification system should be comprised of clear definitions, include patients' and clinicians' perspectives, and have an acceptable number of categories. Methods: Design : A three-round Delphi study. Participants : Thirty Dutch participants (medical specialists, manual therapists, and patients) participated in an online survey...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449262/systematic-review-of-systematic-reviews-for-medical-cannabinoids-pain-nausea-and-vomiting-spasticity-and-harms
#5
G Michael Allan, Caitlin R Finley, Joey Ton, Danielle Perry, Jamil Ramji, Karyn Crawford, Adrienne J Lindblad, Christina Korownyk, Michael R Kolber
OBJECTIVE: To determine the effects of medical cannabinoids on pain, spasticity, and nausea and vomiting, and to identify adverse events. DATA SOURCES: MEDLINE, the Cochrane Database, and the references of included studies were searched. STUDY SELECTION: Systematic reviews with 2 or more randomized controlled trials (RCTs) that focused on medical cannabinoids for pain, spasticity, or nausea and vomiting were included. For adverse events, any meta-analysis for the conditions listed or of adverse events of cannabinoids was included...
February 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29446439/vision-screening-for-correctable-visual-acuity-deficits-in-school-age-children-and-adolescents
#6
REVIEW
Jennifer R Evans, Priya Morjaria, Christine Powell
BACKGROUND: Although the benefits of vision screening seem intuitive, the value of such programmes in junior and senior schools has been questioned. In addition there exists a lack of clarity regarding the optimum age for screening and frequency at which to carry out screening. OBJECTIVES: To evaluate the effectiveness of vision screening programmes carried out in schools to reduce the prevalence of correctable visual acuity deficits due to refractive error in school-age children...
February 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29445269/an-open-label-prospective-interventional-study-of-the-tolerability-and-efficacy-of-0-4-mg-oral-tamsulosin-oral-controlled-absorption-system-in-men-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-who-are-unsatisfied-with-treatment
#7
Pei-Shan Yang, Chien-Lun Chen, Chen-Pang Hou, Yu-Hsiang Lin, Ke-Hung Tsui
Purpose: The aim of this study was to investigate the efficacy and tolerability of switching from 0.2 mg tamsulosin to 0.4 mg tamsulosin oral controlled absorption system (OCAS) over a 12-week period in Taiwanese men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Patients and methods: Taiwanese male patients who were dissatisfied with treatment with 0.2 mg tamsulosin were enrolled in this clinical study and switched to 0...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29441796/heart-failure-symptoms-profile-associated-with-depressive-symptoms
#8
Lucinda J Graven, Melinda K Higgins, Carolyn M Reilly, Sandra B Dunbar
Heart failure (HF) symptoms are known to influence depressive symptoms, yet a symptom profile has not been identified. HF symptoms relative to symptom experience (frequency, severity, interference with physical activity and enjoyment of life) associated with depressive symptoms were examined. Data from three HF studies ( N = 308) which used the Heart Failure Symptom Survey were included in this cross-sectional secondary analysis. Supervised classification for and identification of symptoms most associated with depressive symptoms were accomplished using random forest algorithms via conditional inference trees...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29440805/hypnotic-intervention-for-unexplained-dizziness-in-patients-with-advanced-cancer-a-preliminary-retrospective-observation-study
#9
Hideaki Hasuo, Kenji Kanbara, Mikihiko Fukunaga, Naoko Yunoki
Context: Patients with advanced cancer rarely complain of unexplained dizziness after excluding identifiable causes. Some patients become anxious because they attribute the dizziness to the progression of their cancer. We hypothesize that unexplained dizziness is associated with neck muscle hypertonicity, a noncancer-related secondary effect. However, most cases are associated with neck muscle hypertonicity, a noncancer-related secondary effect. Aims: We evaluated the usefulness of hypnotic intervention that made patients aware of the relation between dizziness and neck muscle hypertonicity through the experience of muscle relaxation and recognition of muscle tension...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29437815/successful-management-of-benign-paroxysmal-positional-vertigo-bppv-in-a-patient-who-was-ventilated-with-a-c3-complete-spinal-injury-on-a-regional-spinal-unit-intensive-care
#10
Lisa Burrows
Benign paroxysmal positional vertigo (BPPV) occurs in 14.5% of patients with spinal cord injury (SCI) and may require intervention on intensive care unit (ICU). A 61-year-old man was admitted to a spinal injury ICU with a traumatic C3 complete SCI following a mountain bike accident. Ventilated but stable he complained of severe dizziness on rolling, during personal cares, which lasted for 40 s. Clinical examination was limited due to the injury and ventilation. Subjective questioning, visio-ocular control and a modified Dix-Hallpike and roll tests confirmed a right posterior canalithiasis BPPV...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437013/topiramate-induced-limbs-paraesthesia-and-rigid-fingers-flexion
#11
Andrea Domenico Pratico, Martino Ruggieri, Raffaele Falsaperla, Piero Pavone
Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. The most frequent side-effects of topiramate include dizziness, somnolence, insomnia, and ataxia. Paraesthesia, metabolic acidosis, kidney stones, hypohidrosis, cognitive impairment and eye symptoms have been also reported...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29435715/clinical-chameleons-an-emergency-medicine-focused-review-of-carbon-monoxide-poisoning
#12
REVIEW
Patrick Chow Yuen Ng, Brit Long, Alex Koyfman
Carbon monoxide (CO) is a colorless, odorless gas that is found in the environment, in the home, and in the human body as a normal part of mammalian metabolism. Poisoning from CO, a common exposure, is associated with significant morbidity and mortality if not recognized and treated in a timely manner. This review evaluates the signs and symptoms of CO poisoning, conditions that present similar to CO poisoning, and an approach to the recognition and management for CO poisoning. CO poisoning accounts for thousands of emergency department visits annually...
February 12, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29435467/a-rare-case-of-sphingomonas-paucimobilis-meningitis-in-the-absence-of-cerebrospinal-fluid-pleocytosis
#13
Hassan Mehmood, Noman Khan, Saad Ullah, Asad Ullah, Asghar Marwat
Sphingomonas paucimobilis is a nonfermentative gram-negative bacillus of low pathogenicity. The organism has been involved in causing a wide range of infections in community and hospital settings. Only 3 cases of meningitis caused by this organism have been reported so far. We report a rare case of S paucimobilis meningitis who presented with atypical symptoms. A 50-year-old female presented with headache, dizziness, chills, shakiness, and neck pain along with nuchal rigidity. On physical examination, severe neck rigidity along with decreased range of motion was noticed...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29434688/nalbuphine-for-analgesia-after-fracture-surgery-and-its-effect-on-circulating-inflammatory-factors
#14
Yong Gong, Yang Zhang, Shoujun Tao
The present study evaluated the use of nalbuphine for analgesia after fraction reduction surgery. Eighty lower limb fracture patients needing open reduction and internal fixation were selected in the First People's Hospital of Jingzhou from January 2015 to December 2015. Patients were randomly divided into observation and control groups (with 40 cases in each). After surgery, the patients in the observation group were treated with nalbuphine (2 mg/kg) for patient-controlled intravenous analgesia (PCIA), while sufentanil (2...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433934/evidence-based-review-of-pharmacotherapy-for-acute-agitation-part-2-safety
#15
Leslie S Zun
BACKGROUND: The management of acute agitation in the emergency department often requires the administration of rapid-acting antipsychotic agents. However, there are few comparative studies and little guidance regarding the risks associated with use of such drugs in the acute setting. OBJECTIVE: This structured evidence-based review compared the safety of antipsychotic pharmacotherapies for acute agitation using data from randomized controlled trials identified by a literature search of the PubMed database...
February 9, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29433838/preliminary-asian-experience-of-using-perampanel-in-clinical-practice
#16
Hsing-I Chiang, Siew-Na Lim, Hsiang-Yao Hsieh, Mei-Yun Cheng, Chun-Wei Chang, Wei-En Johnny Tseng, Han-Tao Li, Chin-Yin Lin, Tony Wu
BACKGROUND: To analyze the efficacy and safety of perampanel over a 3-month period in a sample of Asian people with epilepsy. METHODS: The efficacy and safety of perampanel as an adjunctive therapy for patients with epilepsy were retrospectively reviewed and analyzed. Patients were categorized according to seizure type, concomitant antiepileptic drug usage, and perampanel dosage. RESULTS: A total of 210 patients were included in the study and 131 patients completed 3 months of perampanel treatment...
December 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29433686/gastrodia-elata-alleviates-mutant-huntingtin-aggregation-through-mitochondrial-function-and-biogenesis-mediation
#17
Chuen-Lin Huang, Kaw-Chen Wang, Ying-Chen Yang, Chun-Tang Chiou, Chia-Hui Tan, Yun-Lian Lin, Nai-Kuei Huang
BACKGROUND: According to the Compendium of Materia Medica, Gastrodia elata (GE) Blume is a top-grade herbal medicine frequently used to treat dizziness, headaches, tetanus, and epilepsy, suggesting that it affects neurological functions. Although studies have supported its effects in preventing diverse neurodegenerations such as Huntington's disease (HD), its mechanisms require further investigation. PURPOSE: To investigate the ability of the molecular mechanism of GE to prevent mutant huntingtin (mHTT) protein aggregation by focusing on mitochondrial function and biogenesis, which have been proposed as the therapeutic targets of HD...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29433500/effects-of-local-treatment-with-and-without-sensorimotor-and-balance-exercise-in-individuals-with-neck-pain-protocol-for-a-randomized-controlled-trial
#18
Munlika Sremakaew, Gwendolen Jull, Julia Treleaven, Marco Barbero, Deborah Falla, Sureeporn Uthaikhup
BACKGROUND: Impaired cervical joint position sense and balance are associated with neck pain. Specific therapeutic exercise and manual therapy are effective for improving neck pain and functional ability but their effects on joint position sense and balance impairments remain uncertain. Changes in the joint position sense and balance may need to be addressed specifically. The primary objective is to investigate the most effective interventions to improve impaired cervical joint position sense and balance in individuals with neck pain...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29432219/calcitonin-gene-related-peptide-pathway-mabs-and-migraine-prevention
#19
Koen Paemeleire, Antoinette MaassenVanDenBrink
PURPOSE OF REVIEW: Monoclonal antibodies (mAbs) targeting the calcitonin-gene-related peptide (CGRP) pathway have been developed for episodic and chronic migraine prevention, either through binding the CGRP ligand (eptinezumab, fremanezumab, galcanezumab) or the CGRP receptor (erenumab). We provide an update on published Phase 2 and Phase 3 trials, safety/tolerability data, pharmacokinetics and mechanism of action of these biologicals. RECENT FINDINGS: The efficacy data from Phase 2 trials are corroborated by those from published Phase 3 trials, with a multitude of publications expected in 2018...
February 9, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29429905/health-related-quality-of-life-in-patients-with-poststroke-epilepsy
#20
Yaroslav Winter, Naeimeh Daneshkhah, Nikolaus Galland, Isabel Kotulla, Anna Krüger, Sergiu Groppa
BACKGROUND: Lesional epilepsy is an important long-term sequela of stroke. Data on health-related quality of life (HrQoL) in patients with poststroke epilepsy are limited. We investigated HrQoL in patients with epilepsy after ischemic stroke and identified independent HrQoL-determinants. METHODS AND PATIENTS: All patients with acute ischemic stroke, who were permanent residents in the district Marburg-Biedenkopf (Hessia, Germany, reference population 240,000 inhabitants) were recruited within 12months in the population-based Marburg Stroke Register (MARSTREG)...
February 8, 2018: Epilepsy & Behavior: E&B
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