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https://www.readbyqxmd.com/read/29234822/-acute-vestibular-syndrome-clinical-examination-outperforms-mri-in-the-detection-of-central-lesions
#1
REVIEW
F Thömke
A significant number of patients who seek medical treatment in an emergency department because of vertigo or dizziness, suffer from acute vestibular syndrome. This is characterized by sustained vertigo, horizontal or horizontal rotatory jerk nystagmus, and unsteady stance and gait. In the acute situation it is crucial to differentiate patients with a peripheral vestibular disorder from those with a central disease. A number of recent studies have shown that a structured clinical examination enables a reliable differential diagnosis of central or peripheral disorders...
December 12, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29231438/-infraoccipital-needle-knife-for-cervical-vertigo
#2
Shaofang Li, Manhua Huang, Zhuopeng Lin, Xinze Chen, Dongna Lin, Peng Lu, Qu Lu
OBJECTIVE: To observe the clinical effect differences between infraoccipital needle-knife and massage for cervical vertigo. METHODS: A total of 366 patients with cervical vertigo were randomly assigned into a needle-knife group (186 cases) and a massage group (180 cases). With cases dropping excluded, 183 cases in the needle-knife group and 176 cases in the massage group were included. Needle-knife was used at Fengchi (GB 20), infraoccipital ashi point, etc. in the needle-knife group...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230508/-quality-of-life-and-vertigo-after-bilateral-cochlear-implantation-questionnaires-as-tools-for-quality-assurance
#3
T Rader, M Haerterich, B P Ernst, T Stöver, S Strieth
BACKGROUND: Persistent dizziness symptoms after cochlear implantation have an impact on quality of life. In this study, the effects of bilateral cochlear implants (CI) on quality of life as well as on subjective dizziness complaints are analyzed using questionnaires, some of which have never been applied before in these patient collectives. OBJECTIVE: In this article, questionnaires for the assessment of dizziness symptoms and quality of life are introduced in order to realize quality assurance...
December 11, 2017: HNO
https://www.readbyqxmd.com/read/29227983/bone-conducted-vestibular-evoked-myogenic-potentials-before-and-after-stapes-surgery
#4
Kazuyuki Akazawa, Shigeto Ohta, Kenzo Tsuzuki, Masafumi Sakagami
OBJECTIVE: To identify whether stapes surgery causes otolith dysfunction using bone-conducted vestibular-evoked myogenic potentials (VEMPs). STUDY DESIGN: Prospective study. SETTING: Hyogo College of Medicine Hospital. PATIENTS: Twenty primary ears (19 otosclerosis, 1 congenital stapes fixation) in 17 patients (2 men, 15 women; mean age 51 yr, range 20-68 yr) who had normal cervical VEMP (cVEMP) and ocular VEMP (oVEMP) results with bone-conducted stimulation were included...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29227453/effect-of-prophylactic-medication-on-associated-dizziness-and-motion-sickness-in-migraine
#5
Seung-Han Lee, Seong-Hae Jeong, Ji-Soo Kim, Hyo-Jung Kim, Kwang-Dong Choi, Jae-Hwan Choi, Sun-Young Oh, Ji-Yun Park, Dong Uk Kim, Byung-Kun Kim
OBJECTIVE: To determine the efficacy of prophylactic medications for migraine in reducing associated dizziness and motion sickness. STUDY DESIGN: Multicenter prospective observational study. SETTING: Nationwide 9 Dizziness Clinics in South Korea. PATIENTS: One hundred thirty-eight patients who required a preventive medication for migraine accompanied by dizziness and motion sickness. INTERVENTION: At least one of the prophylactic medications was prescribed among the beta-blockers, calcium channel blockers, tricyclic antidepressants, and antiepileptic drugs...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29226741/side-effects-associated-with-current-and-prospective-antimigraine-pharmacotherapies
#6
Abimael González-Hernández, Bruno A Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M Villalón
Migraine is a neurovascular disorder. Current acute specific antimigraine pharmacotherapies target trigeminovascular 5-HT1B/1D, 5-HT1F and CGRP receptors but, unfortunately, they induce some cardiovascular and central side effects that lead to poor treatment adherence/compliance. Therefore, new antimigraine drugs are being explored. Areas covered. This review considers the adverse (or potential) side effects produced by current and prospective antimigraine drugs, including medication overuse headache (MOH) produced by ergots and triptans, the side effects observed in clinical trials for the new gepants and CGRP antibodies, and a section discussing the potential effects resulting from disruption of the cardiovascular CGRPergic neurotransmission...
December 9, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29225576/vitamin-d-enhances-efficacy-of-oral-nifedipine-in-treating-preeclampsia-with-severe-features-a-double-blinded-placebo-controlled-and-randomized-clinical-trial
#7
Dan-Dan Shi, Yong Wang, Jun-Jun Guo, Ling Zhou, Na Wang
Vitamin D (VD) has exhibited immunomodulatory role in the pathogenesis of preeclampsia. We hypothesize VD potentiate nifedipine treatment for preeclampsia by shortened the time to control blood pressure and prolong time before subsequent hypertensive crisis. We conduct a randomized trial of 683 primigravid women with preeclampsia, who were assigned to different treatment groups, either nifedipine+placebo or nifedipine+VD orally, by random after screening. Primary endpoints include time to control hypertension and time before another hypertensive crisis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29223273/a-79-year-old-woman-with-dyspnea-and-hypoxemia-that-worsened-in-an-upright-position
#8
Tjeerd van der Veer, Johannes C C M In 't Veen, Wijnand K den Dekker, Jelle Miedema
A 79-year-old woman presented to the ED with complaints of gradually worsening exertional dyspnea, dizziness, and chest discomfort. For several weeks she had not been able to perform light household work. The patient's medical history mentioned pulmonary embolism following immobilization (2012), several fractures after trauma, an ischemic cerebral vascular accident (2014), and curative treatment for breast cancer (1995). Her current medication included esomeprazole, clopidogrel, simvastatin, calcium/vitamin D, amitriptyline, and acetaminophen...
December 2017: Chest
https://www.readbyqxmd.com/read/29222203/type-and-frequency-of-side-effects-during-pc6-acupuncture-observations-from-therapists-and-patients-participating-in-clinical-efficacy-trials-of-acupuncture
#9
Anna Enblom, Anna Johnsson
BACKGROUND: Many therapists practise PC6 acupuncture for emesis (nausea and vomiting) during pregnancy, different cancer therapies, palliative care, after surgery, or to induce relaxing effects in general. Knowledge of side effects is central to shared decision-making. AIM: To describe the type and frequency of side effects and the level of needle-induced pain during PC6 acupuncture. METHODS: We included 1298 PC6 acupuncture treatments, delivered to 221 participants (77% women, mean age 52...
December 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29215412/serial-fdg-pet-ct-imaging-in-the-management-of-cardiac-sarcoidosis
#10
William Bremer, Nadera J Sweiss, Yang Lu
A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Because of severe side effects, mycophenolate mofetil was discontinued, and the patient received low-dose steroid therapy...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29214650/perampanel-an-ampa-receptor-antagonist-from-clinical-research-to-practice-in-clinical-settings
#11
REVIEW
J-J Tsai, T Wu, H Leung, T Desudchit, S Tiamkao, K-S Lim, A Dash
Epileptic seizures are refractory to treatment in approximately one-third of patients despite the recent introduction of many newer antiepileptic drugs (AEDs). Development of novel AEDs therefore remains a high priority. Perampanel is a first-in-class non-competitive selective AMPA receptor antagonist with a unique mechanism of action. Clinical efficacy and safety of perampanel as adjunctive treatment for focal seizures with/without secondary generalization (±SG) and primary generalized tonic-clonic (PGTC) seizures have been established in five phase 3 randomized controlled trials (RCTs), and a long-term extension study, and perampanel is approved as monotherapy for focal seizures ±SG in the USA...
December 7, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29210970/evaluating-the-implementation-of-a-preemptive-multimodal-analgesia-protocol-in-a-plastic-surgery-office
#12
Brandi Tinsbloom, Virginia C Muckler, William T Stoeckel, Robert L Whitehurst, Brett Morgan
Many patients undergoing plastic surgery experience significant pain postoperatively. The use of preemptive, multimodal analgesia techniques to reduce postoperative pain has been widely described in the literature. This quality improvement project evaluated the implementation of a preemptive, multimodal analgesia protocol in an office-based plastic surgery facility to decrease postoperative pain, decrease postoperative opioid consumption, decrease postanesthesia care time, and increase patient satisfaction...
October 2017: Plastic Surgical Nursing
https://www.readbyqxmd.com/read/29209540/deglutition-syncope-two-case-reports-attributed-to-vagal-hyperactivity
#13
Sukhdeep Bhogal, Pooja Sethi, Yasir Taha, Muralidhar Papireddy, Akhilesh Mahajan, Syed Imran M Zaidi, Vijay Ramu, Timir Paul
Deglutition syncope is a relatively rare cause of syncope that belongs to the category of neurally mediated reflex syncopal syndromes. The phenomenon is related to vagal reflex in context to deglutition causing atrioventricular block and acute reduction in cardiac output leading to dizziness or syncope. We present case series of two cases of deglutition syncope, of which first was managed medically and second with pacemaker implantation.
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29208729/persistent-postural-perceptual-dizziness-pppd-a-common-characteristic-and-treatable-cause-of-chronic-dizziness
#14
REVIEW
Stoyan Popkirov, Jeffrey P Staab, Jon Stone
Persistent postural-perceptual dizziness (PPPD) is a newly defined diagnostic syndrome that unifies key features of chronic subjective dizziness, phobic postural vertigo and related disorders. It describes a common chronic dysfunction of the vestibular system and brain that produces persistent dizziness, non-spinning vertigo and/or unsteadiness. The disorder constitutes a long-term maladaptation to a neuro-otological, medical or psychological event that triggered vestibular symptoms, and is usefully considered within the spectrum of other functional neurological disorders...
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29208198/-idiopathic-oedema
#15
Christina Courtnadge, Flemming Madsen, Anette Bygum
Idiopathic oedema is a non-inflammatory interstitial oedema seen in fertile women. A hallmark is a daily increase in weight > 1.4 kg from morning until evening due to fluid retention, which shows as facial puffiness in the morning and more often abdominal increase and swollen lower extremities during the day. Patients may be disabled due to accompanying symptoms like headache, dizziness, fatigue, anxiety, and depression. The diagnosis is based on clinical features and exclusion of other causes of oedema...
November 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29204964/a-randomized-double-blind-placebo-controlled-cross-over-trial-vestparoxy-of-the-treatment-of-vestibular-paroxysmia-with-oxcarbazepine
#16
Otmar Bayer, Tatiana Brémová, Michael Strupp, Katharina Hüfner
OBJECTIVE: Vestibular paroxysmia (VP) is characterized by short, often oligosymptomatic attacks of vertigo which occur spontaneously or are sometimes provoked by turning the head. Despite the description of the disease almost 40 years ago (first termed "disabling positional vertigo"), no controlled treatment trial has been published to date. The Vestparoxy trial was designed as a randomized, placebo-controlled, double-blind cross-over trial to examine the therapeutic effect of oxcarbazepine (OXA) in patients with definite or probable VP...
November 27, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29202595/biological-therapies-targeting-arrhythmias-are-cells-and-genes-the-answer
#17
Debbie Falconer, Nikolaos Papageorgiou, Emmanuel Androulakis, Yasmin Alfallouji, Wei Yao Lim, Rui Providencia, Dimitris Tousoulis
Arrhythmias can cause symptoms ranging from simple dizziness to life-threatening circulatory collapse. Current management includes medical therapy and procedures such as catheter ablation or device implantation. However, these strategies still pose a risk of serious side effects, and some patients remain symptomatic. Advancement in our understanding of how arrhythmias develop on the cellular level has made more targeted approaches possible. In addition, contemporary studies have found that several genes are involved in the pathogenesis of arrhythmias...
December 5, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29200911/dual-control-of-the-vestibulosympathetic-reflex-following-hypotension-in-rats
#18
Sang Eon Park, Yuan-Zhe Jin, Byung Rim Park
Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29199066/abuse-liability-assessment-for-biologic-drugs-all-molecules-are-not-created-equal
#19
Christina L Zuch de Zafra, Carrie G Markgraf, David R Compton, Thomas J Hudzik
The development of novel drug candidates involves the thorough evaluation of potential efficacy and safety. To facilitate the safety assessment in light of global increases in prescription drug misuse/abuse, health authorities have developed guidance documents which provide a framework for evaluating the abuse liability of candidate therapeutics. The guidances do not distinguish between small molecules and biologics/biotherapeutics; however, there are key differences between these classes of therapeutics which are important drivers of concern for abuse...
November 30, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29198916/anxiety-related-adverse-events-following-immunization-aefi-a-systematic-review-of-published-clusters-of-illness
#20
Anagha Loharikar, Tiffany A Suragh, Noni E MacDonald, Madhava R Balakrishnan, Oleg Benes, Smaragda Lamprianou, Terri B Hyde, Michael M McNeil
BACKGROUND: Clusters of anxiety-related adverse events following immunization (AEFI) have been observed in several countries and have disrupted country immunization programs. We conducted a systematic literature review to characterize these clusters, to generate prevention and management guidance for countries. METHODS: We searched seven peer-reviewed databases for English language reports of anxiety-related AEFI clusters (≥2 persons) with pre-specified keywords across 4 categories: symptom term, cluster term, vaccine term, and cluster AEFI phenomenon term/phrase...
November 29, 2017: Vaccine
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