Yuan Han, Xiaomin Wei, Guojun Chen, Enge Shao, Yilin Zhou, Yuqing Li, Zhiwen Xiao, Xiaoran Shi, Hao Zheng, Senlin Huang, Yanmei Chen, Yanbing Wang, Yeshen Zhang, Yulin Liao, Wangjun Liao, Jianping Bin, Yuegang Wang, Xinzhong Li
Background: It had been shown that selective cardiac vagal activation holds great potential for heart regeneration. Optogenetics has clinical translation potential as a novel means of modulating targeted neurons. This study aimed to investigate whether cardiac vagal activation via optogenetics could improve heart regenerative repair after myocardial infarction (MI) and to identify the underlying mechanism. Methods: We used an adeno-associated virus (AAV) as the vector to deliver ChR2, a light-sensitive protein, to the left nodose ganglion (LNG)...
2024: International Journal of Biological Sciences