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https://www.readbyqxmd.com/read/29443395/subcutaneous-infusion-of-fluids-for-hydration-or-nutrition-a-review
#1
REVIEW
Riccardo Caccialanza, Thierry Constans, Paolo Cotogni, Gary P Zaloga, Alessandro Pontes-Arruda
Subcutaneous infusion, or hypodermoclysis, is a technique whereby fluids are infused into the subcutaneous space via small-gauge needles that are typically inserted into the thighs, abdomen, back, or arms. In this review, we provide an overview of the technique, summarize findings from studies that have examined the use of subcutaneous infusion of fluids for hydration or nutrition, and describe the indications, advantages, and disadvantages of subcutaneous infusion. Taken together, the available evidence suggests that, when indicated, subcutaneous infusion can be effective for administering fluids for hydration or nutrition, with minimal complications, and has similar effectiveness and safety to the intravenous route...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29440922/is-the-light-at-the-end-of-the-tunnel-nigh-a-review-of-adpkd-focusing-on-the-burden-of-disease-and-tolvaptan-as-a-new-treatment
#2
REVIEW
Rashid A Barnawi, Rahaf Z Attar, Sultan S Alfaer, Osama Y Safdar
Autosomal dominant polycystic kidney disease (ADPKD) causes pathological cystic changes to the kidney and is characterized by numerous renal and systemic manifestations. ADPKD is the fourth most common renal disease requiring renal replacement therapy. In this report, we present a detailed review of ADPKD, with a particular focus on its major economic, psychological, and social burden in affected patients. Treatment of this disease has been based on prophylactic and supportive measures. However, in recent years, new drugs have emerged as promising agents that may retard the progression of ADPKD, such as tolvaptan...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29440013/the-impact-of-new-forms-of-large-scale-general-practice-provider-collaborations-on-england-s-nhs-a-systematic-review
#3
Luisa M Pettigrew, Stephanie Kumpunen, Nicholas Mays, Rebecca Rosen, Rachel Posaner
BACKGROUND: Over the past decade, collaboration between general practices in England to form new provider networks and large-scale organisations has been driven largely by grassroots action among GPs. However, it is now being increasingly advocated for by national policymakers. Expectations of what scaling up general practice in England will achieve are significant. AIM: To review the evidence of the impact of new forms of large-scale general practice provider collaborations in England...
February 12, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29439289/switching-from-reference-adalimumab-to-sb5-adalimumab-biosimilar-in-patients-with-rheumatoid-arthritis-52-week-phase-3-randomized-study-results
#4
Michael E Weinblatt, Asta Baranauskaite, Eva Dokoupilova, Agnieszka Zielinska, Janusz Jaworski, Artur Racewicz, Margarita Pileckyte, Krystyna Jedrychowicz-Rosiak, Inyoung Baek, Jeehoon Ghil
OBJECTIVES: The 24-week equivalent efficacy and comparable safety results of SB5 and reference adalimumab (ADA) from the phase 3 randomized study in patients with moderate to severe rheumatoid arthritis (RA) have been reported previously. This transition study evaluated patients who switched from ADA to SB5 or continued on SB5 or ADA up to 52 weeks. METHODS: In this phase 3 study, patients were initially randomized 1:1 to receive SB5 or ADA (40 mg subcutaneously every other week)...
February 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29438606/experience-and-context-shape-patient-and-clinician-goals-for-treatment-of-rheumatoid-arthritis-a-qualitative-study
#5
Jennifer L Barton, Elizabeth Hulen, Allison Schue, Edward H Yelin, Sarah S Ono, Anais Tuepker, Christopher J Koenig
OBJECTIVE: Patient and clinician goal alignment, central to effective patient-centered care, has been linked to improved patient experience and outcomes, but has not been explored in rheumatoid arthritis (RA). This study aimed to explore goal conceptualization among RA patients and clinicians. METHODS: Seven focus groups and one semi-structured interview were conducted with RA patients and clinicians recruited from four rheumatology clinics. An interview guide was developed to explore goal concordance related to RA treatment...
February 13, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29438575/primary-care-professionals-providing-non-urgent-care-in-hospital-emergency-departments
#6
REVIEW
Daniela Gonçalves-Bradley, Jaspreet K Khangura, Gerd Flodgren, Rafael Perera, Brian H Rowe, Sasha Shepperd
BACKGROUND: In many countries emergency departments (EDs) are facing an increase in demand for services, long waits, and severe crowding. One response to mitigate overcrowding has been to provide primary care services alongside or within hospital EDs for patients with non-urgent problems. However, it is unknown how this impacts the quality of patient care and the utilisation of hospital resources, or if it is cost-effective. This is the first update of the original Cochrane Review published in 2012...
February 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29437535/safety-and-clinical-activity-of-pembrolizumab-and-multisite-stereotactic-body-radiotherapy-in-patients-with-advanced-solid-tumors
#7
Jason J Luke, Jeffrey M Lemons, Theodore G Karrison, Sean P Pitroda, James M Melotek, Yuanyuan Zha, Hania A Al-Hallaq, Ainhoa Arina, Nikolai N Khodarev, Linda Janisch, Paul Chang, Jyoti D Patel, Gini F Fleming, John Moroney, Manish R Sharma, Julia R White, Mark J Ratain, Thomas F Gajewski, Ralph R Weichselbaum, Steven J Chmura
Purpose Stereotactic body radiotherapy (SBRT) may stimulate innate and adaptive immunity to augment immunotherapy response. Multisite SBRT is an emerging paradigm for treating metastatic disease. Anti-PD-1-treatment outcomes may be improved with lower disease burden. In this context, we conducted a phase I study to evaluate the safety of pembrolizumab with multisite SBRT in patients with metastatic solid tumors. Patients and Methods Patients progressing on standard treatment received SBRT to two to four metastases...
February 13, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29436807/-background%C3%A2-the-literature-suggests-that-simulation-is-an-effective-strategy-to-meet-the-learning-needs-of-nursing-students-traditionally-simulation-learning-for-nursing-students-takes-place-at-nursing-schools%C3%A2-at-a-distance-from-the-clinical-setting-patients
#8
Michelle Lalonde, Marie-Christine Malouin-Benoit, Elizabeth Gagnon, Alain Michon, Monique Maisonneuve, Janie Desroches
BACKGROUND: the literature suggests that simulation is an effective strategy to meet the learning needs of nursing students. Traditionally, simulation learning for nursing students takes place at nursing schools ; at a distance from the clinical setting, patients, and the interprofessional team. AIM: the objective of this pilot project is to explore the experiences of Francophone nursing students following their participation in an interprofessional simulation in a hospital setting during their third year clinical placements...
February 2, 2018: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29434629/transcatheter-versus-surgical-aortic-valve-replacement-in-severe-symptomatic-aortic-stenosis
#9
REVIEW
Tsigkas Grigorios, Despotopoulos Stefanos, Makris Athanasios, Koniari Ioanna, Armylagos Stylianos, Davlouros Periklis, Hahalis George
Aortic stenosis (AS) is the most common type of valvular heart disease in the elderly. Surgical aortic valve replacement (SAVR) has been the standard practice for treating severe, symptomatic AS, but recently new treatment options have emerged. Transcatheter aortic valve replacement (TAVR) is now an established treatment option in patients at high surgical risk. In this review, we focus on recent developments and compare the two treatment methods in specific populations in terms of efficacy and safety (e.g...
January 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29433934/evidence-based-review-of-pharmacotherapy-for-acute-agitation-part-2-safety
#10
Leslie S Zun
BACKGROUND: The management of acute agitation in the emergency department often requires the administration of rapid-acting antipsychotic agents. However, there are few comparative studies and little guidance regarding the risks associated with use of such drugs in the acute setting. OBJECTIVE: This structured evidence-based review compared the safety of antipsychotic pharmacotherapies for acute agitation using data from randomized controlled trials identified by a literature search of the PubMed database...
February 9, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29433352/buprenorphine-alone-or-with-naloxone-which-is-safer
#11
Erin Kelty, Craig Cumming, Lakhhina Troeung, Gary Hulse
To address concerns regarding the intravenous diversion of buprenorphine, a combined buprenorphine-naloxone (BUP-NLX) preparation was developed. The aim of this study is to compare health outcomes in opioid dependent patients treated with BUP and BUP-NLX. All patients treated with BUP and/or BUP-NLX in Western Australia between 2001 and 2010 were included in the study ( N = 3455). Patients were identified via State prescribing records and matched against the State mortality, hospital, and emergency department records...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29433063/effects-of-tandospirone-augmentation-in-major-depressive-disorder-patients-with-high-anxiety-a-multicenter-randomized-parallel-controlled-open-label-study
#12
Jingyu Lin, Yunai Su, Chunxia Wang, Fude Yang, Yi Xu, Yonggui Yuan, Yefeng Yuan, Xiaoping Wang, Xin Yu, Tianmei Si
BACKGROUND: High levels of anxiety symptoms are common in individuals with major depressive disorder (MDD). Adjunctive anxiolytics are widely used in such patients; however, only a few studies have examined the strategy using tandospirone. This study aimed to evaluate the efficacy and safety of adjunctive tandospirone in individuals with MDD and high level of anxiety symptoms. METHODS: A multicenter, randomized, parallel-controlled, open-label study was conducted to evaluate the efficacy and safety of tandospirone coupled with selective serotonin reuptake inhibitors (SSRIs) in patients with MDD and high level of anxiety symptoms...
February 9, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29432338/patient-reported-experience-in-the-pediatric-emergency-department-what-matters-most
#13
Mher Barbarian, Andrea Bishop, Patricia Alfaro, Alain Biron, Daniel Adam Brody, Gabrielle Cunningham-Allard, Alexander Sasha Dubrovsky
INTRODUCTION: Although the Child Hospital Consumer Assessment of Healthcare Providers and Systems is a validated tool for the inpatient experience, it may not address features unique to the pediatric emergency department (PED). There is currently no publicly available validated patient-reported experience survey for the PED, and what matters most in this setting remains unknown. METHODS: Twelve semistructured interviews were conducted with a convenience sample of parents of children younger than 14 years at a Canadian PED...
February 9, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29431911/the-years-algorithm-for-suspected-pulmonary-embolism-shorter-visit-time-and-reduced-costs-at-the-emergency-department
#14
L M van der Pol, C E A Dronkers, T van der Hulle, P L den Exter, C Tromeur, C Heringhaus, A T A Mairuhu, M V Huisman, W B van den Hout, F A Klok
BACKGROUND: Recently, the safety of the YEARS algorithm, designed to simplify the diagnostic work-up of pulmonary embolism (PE), was demonstrated. We hypothesize that by design, YEARS would be associated with a shorter diagnostic emergency department (ED) visit time due to simultaneous assessment of pre-test probability and D-dimer level and reduction in CT-scans. AIM: To investigate whether implementation of the YEARS diagnostic algorithm is associated with a shorter ED visit time compared to the conventional algorithm and to evaluate the associated cost savings...
February 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29429912/denosumab-versus-zoledronic-acid-in-bone-disease-treatment-of-newly-diagnosed-multiple-myeloma-an-international-double-blind-double-dummy-randomised-controlled-phase-3-study
#15
Noopur Raje, Evangelos Terpos, Wolfgang Willenbacher, Kazuyuki Shimizu, Ramón García-Sanz, Brian Durie, Wojciech Legieć, Marta Krejčí, Kamel Laribi, Li Zhu, Paul Cheng, Douglas Warner, G David Roodman
BACKGROUND: Multiple myeloma is characterised by monoclonal paraprotein production and osteolytic lesions, commonly leading to skeletal-related events (spinal cord compression, pathological fracture, or surgery or radiotherapy to affected bone). Denosumab, a monoclonal antibody targeting RANKL, reduces skeletal-related events associated with bone lesions or metastases in patients with advanced solid tumours. This study aimed to assess the efficacy and safety of denosumab compared with zoledronic acid for the prevention of skeletal-related events in patients with newly diagnosed multiple myeloma...
February 8, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29429444/safety-and-affordability-of-an-elective-saturday-list-at-pietersburg-hospital-limpopo-south-africa
#16
M M Z U Bhuiyan, R Mavhungu
BACKGROUND: The backlog of patients waiting for operations continues to be a problem in many public hospitals in South Africa (SA), with elective surgery procedures being postponed for up to 2 years. OBJECTIVE: To determine the rate of death in hospital or out of hospital within 30 days of an elective procedure performed on a Saturday, and to determine the cost incurred by paying staff members who perform these operations. METHOD: A prospective, observational descriptive cohort study of all patients undergoing inpatient general surgery operations during weekdays and weekends between 1 September 2015 and 31 August 2016 (1 year) at Pietersburg Hospital (PBH), Limpopo, SA...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29426704/handover-in-intensive-care
#17
G Sirgo Rodríguez, M Chico Fernández, F Gordo Vidal, M García Arias, M S Holanda Peña, B Azcarate Ayerdi, E Bisbal Andrés, A Ferrándiz Sellés, P J Lorente García, M García García, P Merino de Cos, J M Allegue Gallego, A García de Lorenzo Y Mateos, J Trenado Álvarez, P Rebollo Gómez, M C Martín Delgado
Handover is a frequent and complex task that also implies the transfer of the responsibility of the care. The deficiencies in this process are associated with important gaps in clinical safety and also in patient and professional dissatisfaction, as well as increasing health cost. Efforts to standardize this process have increased in recent years, appearing numerous mnemonic tools. Despite this, local are heterogeneous and the level of training in this area is low. The purpose of this review is to highlight the importance of IT while providing a methodological structure that favors effective IT in ICU, reducing the risk associated with this process...
February 6, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29425598/emergency-manuals-how-quality-improvement-and-implementation-science-can-enable-better-perioperative-management-during-crises
#18
REVIEW
Sara N Goldhaber-Fiebert, Carl Macrae
How can teams manage critical events more effectively? There are commonly gaps in performance during perioperative crises, and emergency manuals are recently available tools that can improve team performance under stress, via multiple mechanisms. This article examines how the principles of implementation science and quality improvement were applied by multiple teams in the development, testing, and systematic implementations of emergency manuals in perioperative care. The core principles of implementation have relevance for future patient safety innovations perioperatively and beyond, and the concepts of emergency manuals and interprofessional teamwork are applicable for diverse fields throughout health care...
March 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29425516/reprint-of-building-a-safer-and-faster-car-seatbelts-airbags-and-crispr
#19
REVIEW
Miguel-Angel Perales, Partow Kebriaei, Leslie S Kean, Michel Sadelain
Therapeutic T cell engineering has recently garnered widespread interest because of the success of CD19 chimeric antigen receptor (CAR) therapy. CARs are synthetic receptors for antigen that redirect the specificity and reprogram the function of the T cells in which they are genetically introduced. CARs targeting CD19, a cell surface molecule found in most leukemias and lymphomas, have yielded high remission rates in patients with chemorefractory, relapsed disease, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma...
March 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29424243/forward-i-a-phase-iii-study-of-mirvetuximab-soravtansine-versus-chemotherapy-in-platinum-resistant-ovarian-cancer
#20
Kathleen N Moore, Ignace Vergote, Ana Oaknin, Nicoletta Colombo, Susana Banerjee, Amit Oza, Patricia Pautier, Karim Malek, Michael J Birrer
Mirvetuximab soravtansine, an antibody-drug conjugate that binds with high affinity to folate receptor-α to provide tumor-directed delivery of the potent microtubule-disrupting agent DM4, has emerged as a promising investigational agent for the treatment of ovarian cancer, particularly in the setting of platinum-resistant disease. Here we describe the rationale and design of FORWARD I (NCT02631876), the first randomized, multicenter Phase III study to compare the safety and efficacy of mirvetuximab soravtansine versus investigator's choice of chemotherapy in women with folate receptor-α-positive, platinum-resistant epithelial ovarian, primary peritoneal or fallopian tube cancer...
February 9, 2018: Future Oncology
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