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https://www.readbyqxmd.com/read/29909213/pipeline-embolization-device-flow-diversion-for-a-dissecting-ruptured-posterior-cerebral-artery-aneurysm-in-a-pediatric-patient
#1
Murillo Cunegatto-Braga, Brian Hogan, Pedro Aguilar-Salinas, Alexandra D Beier, Ricardo A Hanel
BACKGROUND: Intracranial aneurysms(IAs) are rare in the pediatric population and are usually considered difficult to treat with traditional microsurgery due to their complex morphology. Endovascular techniques have become the standard option for treating IAs in adults. More recently, flow diverters such as the Pipeline Embolization Device(PED) are being widely adopted for unruptured IAs with safety and efficacy in adults, yet their use in the pediatric population is not well defined. In this paper we present a pediatric patient with a ruptured PCA aneurysm successfully treated with a PED and a review of the literature of the current status of PED use in this subset of patients...
June 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29909113/coronary-computed-tomography-angiography-versus-stress-echocardiography-in-acute-chest-pain-a-randomized-controlled-trial
#2
Jeffrey M Levsky, Linda B Haramati, Daniel M Spevack, Mark A Menegus, Terence Chen, Sarah Mizrachi, Durline Brown-Manhertz, Samantha Selesny, Rikah Lerer, Deborah J White, Jonathan N Tobin, Cynthia C Taub, Mario J Garcia
OBJECTIVES: This study sought to compare early emergency department (ED) use of coronary computed tomography angiography (CTA) and stress echocardiography (SE) head-to-head. BACKGROUND: Coronary CTA has been promoted as the early ED chest pain triage imaging method of choice, whereas SE is often overlooked in this setting and involves no ionizing radiation. METHODS: The authors randomized 400 consecutive low- to intermediate-risk ED acute chest pain patients without known coronary artery disease and a negative initial serum troponin level to immediate coronary CTA (n = 201) or SE (n = 199)...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29908763/acceptability-and-feasibility-of-naloxone-prescribing-in-primary-care-settings-a-systematic-review
#3
REVIEW
Emily Behar, Rita Bagnulo, Phillip O Coffin
Naloxone access through established healthcare settings is critical to responding to the opioid crisis. We conducted a systematic review to assess the acceptability and feasibility of prescribing naloxone to patients in primary care. We queried PubMed, EmBase and CINAHL for US-based, peer-reviewed, full-length, original articles relating to acceptability or feasibility of prescribing naloxone in primary care. Searches yielded 270 unduplicated articles; one analyst reviewed all titles and abstracts. Two analysts independently reviewed eligible articles for study design, study outcome, and acceptability and/or feasibility...
June 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29908672/changing-the-neurology-policy-landscape-in-the-united-states-misconceptions-and-facts-about-epilepsy
#4
David C Grabowski, Jesse Fishman, Imane Wild, Bruce Lavin
Epilepsy has a relatively high prevalence, and diagnosis and treatment are often challenging. Seizure freedom without significant side effects is the ultimate goal for both physicians and patients, but not always achievable. In those cases, the treatment goals of patients and providers may differ. In the United States, many clinicians continue to prescribe older AEDs, even though newer AEDs have a more desirable safety and tolerability profile, fewer drug-drug interactions, and are associated with lower epilepsy-related hospital visits...
May 26, 2018: Health Policy
https://www.readbyqxmd.com/read/29908435/brivaracetam-induced-elevation-of-carbamazepine-epoxide-levels-a-post-hoc-analysis-from-the-clinical-development-program
#5
Martin J Brodie, Toufic Fakhoury, Belinda McDonough, Anny-Odile Colson, Armel Stockis, Sami Elmoufti, John Whitesides
To assess the association, if any, between brivaracetam (BRV)-induced elevated carbamazepine-10,11-epoxide (CBZ-E) and toxicity and efficacy in patients with epilepsy. Data were pooled from three double-blind, placebo-controlled, Phase III studies of adjunctive BRV in adults with uncontrolled focal seizures (N01252/NCT00490035, N01253/NCT00464269, N01358/NCT01261325). Treatment-emergent adverse events (TEAEs) of interest (ataxia, diplopia, dizziness, nystagmus, somnolence, accidental overdose or poisoning, and toxicity), discontinuations due to TEAEs, and serious TEAEs (SAEs) were assessed in subgroups who did/did not receive carbamazepine (CBZ) at study entry (CBZ+ and CBZ-)...
June 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29908043/a-first-in-human-study-of-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-pf-06741086-an-anti-tfpi-monoclonal-antibody-in-healthy-volunteers
#6
Matthew Cardinal, Constantino Kantaridis, Tong Zhu, Pengling Sun, Debra D Pittman, John E Murphy, Steven Arkin
BACKGROUND: Tissue factor pathway inhibitor (TFPI) is a protease inhibitor of tissue factor-activated coagulation factor VII (TF-FVIIa) complex and activated factor X (FXa). PF-06741086 is a monoclonal antibody that targets TFPI to increase clotting activity. OBJECTIVES: This study was a randomized, double-blind, sponsor-open, placebo-controlled, single intravenous (IV) or subcutaneous (SC) dose escalation study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-06741086...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29905383/guselkumab-an-anti-interleukin-23-monoclonal-antibody-for-the-treatment-of-moderate-to-severe-plaque-type-psoriasis-in-japanese-patients-efficacy-and-safety-results-from-a-phase-3-randomized-double-blind-placebo-controlled-study
#7
Mamitaro Ohtsuki, Hiroshi Kubo, Hitomi Morishima, Ryosuke Goto, Richuan Zheng, Hidemi Nakagawa
Previous global studies of guselkumab have demonstrated clinical benefits in patients with psoriasis. The aim of this 52-week, phase 3 study was to evaluate efficacy and safety of guselkumab in Japanese patients with moderate to severe plaque-type psoriasis. Patients randomly received guselkumab 50 mg or 100 mg at weeks 0, 4 and every 8 weeks, or placebo with cross-over to guselkumab 50 mg or 100 mg at week 16. Co-primary end-points were the proportion of patients achieving Investigator's Global Assessment (IGA) cleared/minimal (0/1) and 90% or more improvement in Psoriasis Area and Severity Index (PASI-90) at week 16...
June 15, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29903520/a-meta-analysis-of-randomized-controlled-trials-of-uninterrupted-periprocedural-anticoagulation-strategy-in-patients-undergoing-atrial-fibrillation-catheter-ablation
#8
Yating Zhao, Yao Lu, Yue Qin
BACKGROUND: In patients undergoing atrial fibrillation (AF) ablation, despite uninterrupted oral anticoagulants (OACs) have been recommended, no consensus has emerged regarding to whether uninterrupted novel oral anticoagulants (NOACs) are superior to uninterrupted vitamin K antagonists (VKAs) for the periprocedural antithrombotic management. This meta-analysis aimed to compare the efficacy and safety of uninterrupted NOACs and uninterrupted VKAs in patients undergoing AF ablation. METHODS: Databases were searched for articles published up to March 20, 2018...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29902738/simulation-for-emergency-nurses-siren-a-quasi-experimental-study
#9
Mary Boyde, Emily Cooper, Hannah Putland, Rikki Stanton, Christie Harding, Ben Learmont, Clare Thomas, Jade Porter, Andrea Thompson, Louise Nicholls
BACKGROUND: Within nursing education, simulation has been recognised as an effective learning strategy. Embedding simulation within clinical units has the potential to enhance patient safety and improve clinical outcomes. However it is important to evaluate the effectiveness of this educational technique to support the actual value and effectiveness. OBJECTIVE: This study aimed to implement and evaluate an innovative simulation experience for registered nurses. METHODS: A high-fidelity simulation focusing on nursing assessment was conducted with 50 Registered Nurses in an Emergency Department (ED) at a large tertiary referral hospital...
June 5, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29901654/patient-and-physician-experience-with-interhospital-transfer-a-qualitative-study
#10
Stephanie K Mueller, Evan Shannon, Anuj Dalal, Jeffrey L Schnipper, Patricia Dykes
OBJECTIVES: Although existing data suggest marked variability in interhospital transfer (IHT), little is known about specific factors that may impact the quality and safety of this care transition. We aimed to explore transferred patients' and involved physicians' experience with IHT to better understand the components of the transfer continuum and identify potential targets for improvement. METHODS: We performed a qualitative study using individual interviews of adult patients recently transferred to cardiology, general medicine, and oncology services at a tertiary care academic medical center, as well as their transferring physician, accepting attending physician, and accepting/admitting resident physician...
June 12, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29900817/feasibility-of-same-day-discharge-after-robotic-assisted-pelvic-floor-reconstruction
#11
Jessica C Lloyd, Juan Guzman-Negron, Howard B Goldman
INTRODUCTION: Robotic surgical procedures have become more common in female pelvic reconstruction. Purported benefits of robotic assisted pelvic floor reconstruction (RAPFR) procedures include shorter hospital stay, faster recovery, lower blood loss, and decreased postoperative pain. Following RAPFR procedures, the current accepted practice is discharge after a one-night hospitalization. We assessed whether same day discharge (SDD) affects the short term safety of and patient satisfaction with robotic assisted pelvic floor reconstructive procedures, relative to those who remain hospitalized overnight...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29898788/immunomodulatory-activities-of-pixatimod-emerging-nonclinical-and-clinical-data-and-its-potential-utility-in-combination-with-pd-1-inhibitors
#12
Edward Hammond, Nicole M Haynes, Carleen Cullinane, Todd V Brennan, Darryn Bampton, Paul Handley, Tomislav Karoli, Fleur Lanksheer, Liwen Lin, Yiping Yang, Keith Dredge
BACKGROUND: Pixatimod (PG545) is a novel clinical-stage immunomodulatory agent capable of inhibiting the infiltration of tumor-associated macrophages (TAMs) yet also stimulate dendritic cells (DCs), leading to activation of natural killer (NK) cells. Preclinically, pixatimod inhibits heparanase (HPSE) which may be associated with its inhibitory effect on TAMs whereas its immunostimulatory activity on DCs is through the MyD88-dependent TLR9 pathway. Pixatimod recently completed a Phase Ia monotherapy trial in advanced cancer patients...
June 14, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29897589/efficacy-of-lubiprostone-for-the-treatment-of-opioid-induced-constipation-analyzed-by-opioid-class
#13
Lynn R Webster, Randall P Brewer, Peter Lichtlen, Taryn Losch-Beridon, Shadreck Mareya, Martin Wang
Objectives: To examine the efficacy and safety of lubiprostone for the treatment of opioid-induced constipation (OIC) in patients by opioid class received. Design: Data were pooled from three phase III, randomized, double-blind, placebo-controlled studies. Subjects/Setting: Adults with chronic noncancer pain receiving opioid therapy for 30 or more days and diagnosed with OIC. Methods: Overall mean change from baseline in spontaneous bowel movement (SBM) frequency, overall treatment response (≥1 SBM/week improvement over baseline SBM frequency in all treatment weeks with available data and ≥3 SBMs/week for ≥9 of the 12 weeks of treatment), and OIC-related symptoms were examined in patients taking opioids...
June 1, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29894440/psychometric-analysis-of-a-survey-on-patient-safety-culture-based-tool-for-emergency-medical-services
#14
Remle P Crowe, Rebecca E Cash, Alex Christgen, Tina Hilmas, Lee Varner, Amy Vogelsmeier, William S Gilmore, Ashish R Panchal
OBJECTIVE: Evaluating organizational safety culture is critical for high-stress, high-risk professions such as prehospital emergency medical services (EMS). The aim of the study was to evaluate the psychometric properties of a safety culture instrument for EMS, based on the Agency for Healthcare Research and Quality's widely used Surveys on Patient Safety Culture (SOPS). METHODS: The final EMS-adapted instrument consisted of 37 items covering 11 safety culture domains including 10 domains from existing SOPS instruments and one new domain for communication while en route to an emergency call...
June 11, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29893658/a-retrospective-analysis-of-adverse-events-among-patients-receiving-daptomycin-versus-vancomycin-during-outpatient-parenteral-antimicrobial-therapy
#15
Gregory M Schrank, Sharon B Wright, Westyn Branch-Elliman, Mary T LaSalvia
OBJECTIVE: Outpatient parenteral antimicrobial therapy (OPAT) is a safe and effective alternative to prolonged inpatient stays for patients requiring long-term intravenous antimicrobials, but antimicrobial-associated adverse events remain a significant challenge. Thus, we sought to measure the association between choice of antimicrobial agent (vancomycin vs daptomycin) and incidence of adverse drug events (ADEs). METHODS: Patients receiving OPAT treatment with vancomycin or daptomycin for skin and soft-tissue infections, bone and joint infections, endocarditis, and bacteremia or endovascular infections during the period from July 1, 2013, through September 30, 2016, were included...
June 12, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29893436/envisioning-successful-teamwork-an-exploratory-qualitative-study-of-team-processes-used-by-nursing-teams-in-a-paediatric-hospital-unit
#16
Leeann Whitehair, John Hurley, Steve Provost
AIMS AND OBJECTIVES: To explore how team processes support nursing teams in hospital units during every day work. BACKGROUND: Due to their close proximity to patients, nurses are central to the process of maintaining patient safety. Globally, changes in models of care delivery by nurses, inclusive of team nursing are being considered. DESIGN AND METHODS: This qualitative study used purposive sampling in a single hospital and participants were nurses employed to work on a paediatric unit...
June 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29893068/wearables-in-medicine
#17
Ali K Yetisen, Juan Leonardo Martinez-Hurtado, Barış Ünal, Ali Khademhosseini, Haider Butt
Wearables as medical technologies are becoming an integral part of personal analytics, measuring physical status, recording physiological parameters, or informing schedule for medication. These continuously evolving technology platforms do not only promise to help people pursue a healthier life style, but also provide continuous medical data for actively tracking metabolic status, diagnosis, and treatment. Advances in the miniaturization of flexible electronics, electrochemical biosensors, microfluidics, and artificial intelligence algorithms have led to wearable devices that can generate real-time medical data within the Internet of things...
June 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29891528/advances-in-immunotherapy-for-metastatic-merkel-cell-carcinoma-a-clinician-s-guide
#18
REVIEW
Kelly G Paulson, Shailender Bhatia
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer. The clinical impact of MCC has been increasing due to steadily rising incidence rates. Since 2001, more than 24,000 cases of MCC have been reported to the US National Program of Cancer Registries database, and in 2018, more than 2,500 incident cases are expected. MCC is highly aggressive, and one-third of patients will either present with or develop metastatic disease. Outcomes in patients with metastatic MCC have historically been poor; median time to progression with cytotoxic chemotherapy is only 3 months...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29890643/mini-review-assessing-the-potential-impact-of-microneedle-technologies-on-home-healthcare-applications
#19
REVIEW
Aaron McConville, Catherine Hegarty, James Davis
The increasing devolution of healthcare towards community care has meant that the management of many conditions is conducted within the home either by community nurses or by the patients themselves. The administration of medicines within home healthcare scenarios can however be problematic—especially when considering the delivery of medicines through injection. The possibility of needlestick injury (NSI) has become an ever-present hazard within healthcare settings, with a significant proportion of percutaneous injuries occurring during the handling and disposal of the needle...
June 8, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29889745/simulation-in-obstetrics
#20
Andrew J Satin
Simulation in obstetrics is a widely accepted and valuable tool that benefits all levels of learners from medical students to maternal-fetal medicine subspecialists. What began as an adjunct to medical education now has a rapidly expanding role in acquisition of new and innovative procedures, team and unit training, and safety and quality initiatives. The number of obstetric simulation peer-reviewed reports has increased exponentially in recent years, yet only a small percentage of reports primarily addresses clinical outcomes...
June 6, 2018: Obstetrics and Gynecology
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