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https://www.readbyqxmd.com/read/28521775/genome-wide-association-study-of-subclinical-interstitial-lung-disease-in-mesa
#1
Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C Borczuk, Jennifer N Nguyen, Ganesh Raghu, Eric A Hoffman, Suna Onengut-Gumuscu, Emily A Farber, Joel D Kaufman, Dan Rabinowitz, Karen D Hinckley Stukovsky, Steven M Kawut, Gary M Hunninghake, George R Washko, George T O'Connor, Stephen S Rich, R Graham Barr, David J Lederer
BACKGROUND: We conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis Study. METHODS: We measured the percentage of high attenuation areas (HAA) in the lung fields on cardiac CT scan defined as voxels with CT attenuation values between -600 and -250 HU. Genetic analyses were performed in MESA combined across race/ethnic groups: non-Hispanic White (n = 2,434), African American (n = 2,470), Hispanic (n = 2,065) and Chinese (n = 702), as well as stratified by race/ethnicity...
May 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28520641/five-year-follow-up-after-epiretinal-membrane-surgery-a-single-center-experience
#2
Efrat Fleissig, Dinah Zur, Elad Moisseiev, Shay Keren, Oded Ohana, Adiel Barak
PURPOSE: To evaluate the rate of epiretinal membrane (ERM) recurrence in eyes that underwent ERM peeling surgery at least 5 years earlier. METHODS: Retrospective interventional case series study of 37 patients (15 women and 22 men; mean age, 70 ± 7.6 years) operated on for ERM removal with a follow-up of at least 5 years. The patients underwent testing for visual acuity, an ophthalmic examination, and optical coherence tomography imaging, all of which were assessed preoperatively, postoperatively, and at the 5-year follow-up...
May 16, 2017: Retina
https://www.readbyqxmd.com/read/28518173/simultaneous-quantification-of-n-and-o-glycans-using-a-solid-phase-method
#3
Shuang Yang, Yingwei Hu, Lori Sokoll, Hui Zhang
Glycosylation has a pivotal role in a diverse range of biological activities, modulating the structure and function of proteins. Glycogens coupled to the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine and threonine side chains represent the two major protein glycosylation forms. N-glycans can be released by glycosidases, whereas O-glycans are often cleaved by chemical reaction. However, it is challenging to combine these enzymatic and chemical reactions in order to analyze both N- and O-glycans...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28516293/the-dominant-allele-aft-induces-a-shift-from-flavonol-to-anthocyanin-production-in-response-to-uv-b-radiation-in-tomato-fruit
#4
Stefano Catola, Antonella Castagna, Marco Santin, Valentina Calvenzani, Katia Petroni, Andrea Mazzucato, Annamaria Ranieri
The introgression of the A ft allele into domesticated tomato induced a shift from flavonol to anthocyanin production in response to UV-B radiation, while the hp - 1 allele negatively influenced the response of flavonoid biosynthesis to UV-B. Introgression of the dominant allele Anthocyanin fruit (Aft) from Solanum chilense induces anthocyanin accumulation in the peel of tomato (Solanum lycopersicum L.) fruit. UV-B radiation can influence plant secondary metabolism regulating the expression of several genes, among which those involved in flavonoid biosynthesis...
May 17, 2017: Planta
https://www.readbyqxmd.com/read/28515649/effect-of-persimmon-peel-diospyros-kaki-thumb-extracts-on-lipid-and-protein-oxidation-of-raw-ground-pork-during-refrigerated-storage
#5
Ju-Hui Choe, Hack-Youn Kim, Cheon-Jei Kim
The inhibition effect of persimmon peel extracts (PPE) (0.05(PPE-0.05), 0.1(PPE-0.1), and 0.2 g(PPE-0.2) per meat sample) on lipid and protein oxidation of pork patties during chilled storage for 12 days were investigated and compared to ascorbic acid (As-0.05) and butylhydroxytoluene (BHT) (BHT-0.01). The meat samples treated with PPE had greater (p<0.05) a* values comparing control in raw pork patties meat from day 4 of storage. The addition of PPE at all concentrations on meat samples effectively inhibited the formation of oxidation products as shown by decreasing conjugated dienes (CD), peroxide values (POVs), thiobarbituric acid reaction substances (TBARS), and carbonyl content during chilled storage for 12 d...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28515182/health-assets-in-older-age-a-systematic-review
#6
Yvonne Claire Hornby-Turner, Nancye May Peel, Ruth Eleanor Hubbard
BACKGROUND: Finding ways to optimise health in older age is key to reducing the impact of population ageing on health and social care systems. A salutogenic approach takes into account an individual's health assets-internal or external strengths or accessible resources which improve and preserve physical, social and mental wellness, independence and quality of life. The aim of this narrative systematic review was to provide a summary and appraisal of the evidence for factors that act as health assets within personal, social, economic and environmental domains...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28514152/hepatoprotective-properties-of-a-polyphenols-enriched-fraction-from-annona-crassiflora-mart-fruit-peel-against-diabetes-induced-oxidative-and-nitrosative-stress
#7
Allisson B Justino, Mariana N Pereira, Leonardo G Peixoto, Danielle D Vilela, Douglas C Caixeta, Adriele V de Souza, Renata R Teixeira, Heitor C G Silva, Francyelle B R de Moura, Izabela B Moraes, Foued Salmen Espindola
A polyphenols-enriched fraction from Annona crassiflora fruit peel (Ac-Pef) containing chlorogenic acid, (epi)catechin, procyanidin B2 and caffeoyl-glucoside was investigated against hepatic oxidative and nitrosative stress in streptozotocin-induced diabetic rats. Serum biochemical parameters, hepatic oxidative and nitrosative status, glutathione defense system analysis, and in silico assessment of absorption, distribution, metabolism, excretion and toxicity (ADMET) of the main compounds of Ac-Pef were carried out...
May 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28508662/keeping-your-eyes-peeled-for-corneal-ulcers
#8
Perry C Morocco, Matthew A Broom
No abstract text is available yet for this article.
May 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28508065/the-ground-truth-about-metadata-and-community-detection-in-networks
#9
Leto Peel, Daniel B Larremore, Aaron Clauset
Across many scientific domains, there is a common need to automatically extract a simplified view or coarse-graining of how a complex system's components interact. This general task is called community detection in networks and is analogous to searching for clusters in independent vector data. It is common to evaluate the performance of community detection algorithms by their ability to find so-called ground truth communities. This works well in synthetic networks with planted communities because these networks' links are formed explicitly based on those known communities...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28507406/evaluation-of-different-agroindustrial-waste-on-the-effect-of-different-carcass-characteristics-and-physiological-and-biochemical-parameters-in-broilers-chicken
#10
Y Sánchez-Roque, Y D C Pérez-Luna, E Pérez-Luna, R Berrones Hernández, S Saldaña-Trinidad
AIM: This study was conducted to evaluate the physiological and biochemical effect in chickens of the Ross breed of a food enriched with agroindustrial waste. MATERIALS AND METHODS: The food is one of the main components of the total cost for the production of chickens. Rations should be formulated to provide the correct balance of energy, protein, amino acids, minerals, vitamins and essential fatty acids, to allow optimal growth and performance. This study was intended to evaluate a natural feed for chicken, made from corn, yucca meal, eggshells, orange peel, soybean meal, salt and garlic, enriched with agroindustrial waste (molasses, milk whey and ferment of coffee)...
April 2017: Veterinary World
https://www.readbyqxmd.com/read/28505165/determination-of-fruit-maturity-and-its-prediction-model-based-on-the-pericarp-index-of-absorbance-difference-iad-for-peaches
#11
Binbin Zhang, Bin Peng, Chunhua Zhang, Zhizhong Song, Ruijuan Ma
Harvest maturity is closely related to peach fruit quality and has a very important effect on the fresh fruit market. Unfortunately, at present, it is difficult to determine the maturity level of peach fruits by artificial methods. The objectives of this study were to develop quadratic polynomial regression models using near-infrared spectroscopy that could determine the peel color difference, fruit firmness, soluble solids content (SSC), soluble sugar, organic acid components, and their relationships with the absorbance of chlorophyll (index of absorbance difference, IAD) in late maturing 'Xiahui 8' peach and 'Xiaguang' nectarine fruits...
2017: PloS One
https://www.readbyqxmd.com/read/28504174/pineapple-peel-carboxymethyl-cellulose-polyvinyl-alcohol-mesoporous-silica-sba-15-hydrogel-composites-for-papain-immobilization
#12
Hongjie Dai, Shiyi Ou, Zhijun Liu, Huihua Huang
Hydrogel composites based on pineapple peel carboxymethyl cellulose, polyvinyl alcohol and mesoporous silica SBA-15 were synthesized by an eco-friendly method of repeated freeze-thaw cycles for the application of papain immobilization. The experiment was optimized to obtain an efficient papain immobilization carrier. Simultaneously the immobilization conditions, including enzyme concentration, pH, crosslinker concentration and cross-linking time were optimized. The immobilized papain had maximum activity at low reaction temperature of 40°C and showed pH-sensitivity by exhibiting a rapid decrease of activity within a narrow range from pH 7...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28500228/a-liana-from-the-lower-miocene-of-panama-and-the-fossil-record-of-connaraceae
#13
Nathan A Jud, Chris W Nelson
PREMISE OF THE STUDY: Permineralized wood is common in the Miocene beds exposed during the expansion of the Panama Canal. We describe a stem with the distinctive anatomy of a liana and evaluate the evolutionary, biogeographic, and ecological significance of this discovery. METHODS: The object of the study was obtained from a collection of fossil woods and fruits from a locality in the lower Miocene Cucaracha Formation, where the formation is exposed by the Culebra Cut of the Panama Canal...
May 12, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28499057/adaptive-optics-scanning-laser-ophthalmoscopy-and-multimodal-imaging-of-peau-d-orange-in-pseudoxanthoma-elasticum
#14
Alex C Onishi, Peter L Nesper, Amani A Fawzi
A 41-year-old male with pseudoxanthoma elasticum who presented with progressive vision loss in his left periphery is discussed. Bilateral angioid streaks, optic disc drusen, choroidal neovascularization, and peau d'orange were present. Imaging of the area with peau d'orange with adaptive optics scanning laser ophthalmoscopy and en face optical coherence tomography at Bruch's membrane (BM) revealed a pattern identical to the patches of peau d'orange visible with conventional fundus imaging techniques. These results show that structural abnormalities at the level of BM, likely a result of calcification, correlate with the characteristic "orange peel" pattern known as peau d'orange...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28498936/a-phase-1-dose-escalation-study-of-oral-5-aminolevulinic-acid-in-adult-patients-undergoing-resection-of-a-newly-diagnosed-or-recurrent-high-grade-glioma
#15
Jeffrey W Cozzens, Barbara C Lokaitis, Brian E Moore, Devin V Amin, José A Espinosa, Margaret MacGregor, Alex P Michael, Breck A Jones
BACKGROUND: The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented. This drug has received regulatory approval in Europe but awaits approval in the United States. OBJECTIVE: To identify the appropriate dose and toxicity or harms of 5-ALA used for enhanced intraoperative visualization of malignant brain tumors, reported from a single medical center in the United States. METHODS: Prior to craniotomy for resection of a presumed high-grade glioma, individuals were given oral 5-ALA as part of a rapid dose-escalation scheme...
May 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28498204/asds-guidelines-task-force-consensus-recommendations-regarding-the-safety-of-lasers-dermabrasion-chemical-peels-energy-devices-and-skin-surgery-during-and-after-isotretinoin-use
#16
Abigail Waldman, Diana Bolotin, Kenneth A Arndt, Jeffrey S Dover, Roy G Geronemus, Anne Chapas, Sanjana Iyengar, Suzanne L Kilmer, Andrew C Krakowski, Naomi Lawrence, Heidi B Prather, Thomas E Rohrer, Bethanee J Schlosser, John Y S Kim, Peter R Shumaker, Leah K Spring, Murad Alam
BACKGROUND: Currently, the isotretinoin (13-cis-retinoic acid) package insert contains language advising the discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. It is common practice to follow this standard because of concerns regarding reports of sporadic adverse events and increased risk of scarring. OBJECTIVE: To develop expert consensus regarding the safety of skin procedures, including resurfacing, energy device treatments, and incisional and excisional procedures, in the setting of concurrent or recent isotretinoin use...
May 10, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28498122/optimization-of-adsorption-process-parameters-by-response-surface-methodology-for-hexavalent-chromium-removal-from-aqueous-solutions-using-annona-reticulata-linn-peel-microparticles
#17
N Saranya, E Nakeeran, M S Giri Nandagopal, N Selvaraju
Fruit peel microparticles of Annona reticulata Linn were used as biosorbent for the sequestration of hexavalent chromium (CR(VI)). Characterization of the biosorbent was done using scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDXS), Fourier transfer infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GCMS), carbon, hydrogen, nitrogen and sulphur (CHNS) elemental analysis, mercury intrusion porosimetry and point of zero charge. Influential parameters were optimized using response surface methodology (RSM) with a total of 17 experimental runs based on the Box-Behnken design and found to be pH 1...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28494562/-intraoperative-risk-factors-associated-with-visual-acuity-outcomes-of-pars-plana-vitrectomy-in-idiopathic-epiretinal-membrane
#18
H H Li, X Liao, C L Xie, X R Gao, H Wang, F Wang
Objective: To evaluate intraoperative risk factors related to the postoperative visual acuity in idiopathic epiretinal membrane (IERM) . Methods: According to the well-established study criterion, a retrospective observational study was carried out on 37 eyes of 37 patients with epiretinal membrane peeling surgery for IERM between January 2014 and January 2015. Intraoperative situations during membrane peeling were documented, including complexity of operation, superficial hemorrhage and the state of indocyanine green (ICG) staining...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494561/-observation-of-single-layered-inverted-internal-limiting-membrane-flap-technique-for-macular-hole-with-retinal-detachment-in-high-myopia
#19
C Z Xu, J H Wu, J W He, C Feng
Objective: To compare the outcome of pars plana vitrectomy (PPV) with a single-layered inverted internal limiting membrane (ILM) flap versus PPV with ILM peeling for the treatment of macular hole associated retinal detachment (MHRD) in high myopia. Methods: In a retrospective cohort study, PPV with 2 kinds of adjuvant surgical procedures were used in 35 moderately high myopia eyes with MHRD. These eyes were divided into 2 groups: group 1 (17 eyes) receiving PPV and ILM peeling and group 2 (18 eyes) receiving PPV with a single-layered inverted ILM flap...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28492374/a-miniaturized-wall-climbing-segment-robot-inspired-by-caterpillar-locomotion
#20
Il Whan Han, Hoon Yi, Chang-Woo Song, Hoon-Eui Jeong, Seung-Yop Lee
Caterpillars are very successful soft-bodied climbers that navigate in complex environments. This paper develops a multi-segmented robot climbing on vertical surfaces using dry adhesive pads, inspired by caterpillar locomotion. The miniaturized robot consists of four segments, and each segment uses a solenoid actuator with a permanent magnet plunger. The head and body segments adapt a novel mechanism and Scott-Russell linkages to generate a bi-directional plane motion using one solenoid actuator, resulting to reliable attaching and peeling motions of gecko pads...
May 11, 2017: Bioinspiration & Biomimetics
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