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https://www.readbyqxmd.com/read/29333029/flagellate-rash-an-unusual-complication-of-bleomycin-therapy-a-case-report-with-brief-review-of-literature
#1
Chaturbhuj Agrawal, Vineet Talwar, Rajeev Saini, Pradeep Babu
Chemotherapy-induced skin rashes are common toxicities encountered which require careful assessment and evaluation as rashes could be a manifestation of primary malignancy itself and a variety of drugs used in combination further complicate the clinical scenario. Bleomycin is an anticancer antibiotic derived from Streptomyces verticillus and has been commonly used in the treatment of Hodgkin's disease, germ cell tumors and for pleurodesis. There are various dermatological adverse effects of bleomycin which have been previously reported in literature including skin peeling, hyperkeratosis, nail bed changes, Raynaud's phenomenon, and palmoplantar desquamation...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29331510/effects-of-sub-minimum-inhibitory-concentrations-of-lemon-essential-oil-on-the-acid-tolerance-and-biofilm-formation-of-streptococcus-mutans
#2
Yanwei Sun, Sijia Chen, Chen Zhang, Yali Liu, Li Ma, Xiangyu Zhang
OBJECTIVES: Lemon essential oil (LEO) is a kind of secondary metabolite from lemon peels and has been found to inhibit cariogenic bacteria for decades. However, its effects on main cariogenic virulence factors are rarely reported. The present study aimed to investigate the effects of sub-minimum inhibitory concentrations (sub-MICs) of LEO on the acid tolerance and biofilm formation of Streptococcus mutans (S. mutans) and preliminarily reveal the possible underlying mechanisms. DESIGNS: Effects of LEO on the acid tolerance and biofilm formation of S...
December 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29330852/characteristics-and-intestinal-immunomodulating-activities-of-water-soluble-pectic-polysaccharides-from-chenpi-with-different-storage-periods
#3
Changcheng Tian, Xu Hui, Jing Li, Zhuo Han
BACKGROUND: Traditional view considers that the long-term stored Chenpi (dried citrus peel) has better health efficacies as compared with the fresh Chenpi, but the detailed mechanism remains obscure. RESULTS: The three water-soluble pectic polysaccharides (CPP1, CPP5 and CPP10) were obtained from one-year, five-year and ten-year Chenpi, respectively, and their physicochemical characteristics and intestinal immunomodulating activities were investigated and compared...
January 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29329862/active-compounds-antioxidant-activity-and-%C3%AE-glucosidase-inhibitory-activity-of-different-varieties-of-chaenomeles-fruits
#4
Jing Miao, Xia Li, Chengcheng Zhao, Xiaoxiao Gao, Ying Wang, Wenyuan Gao
Chaenomeles is an important source for food industry in China, and its planting area is expanding year by year. This study was conducted to evaluate different varieties of Chaenomeles by comparing the chemical compositions, antioxidant activity and α-glucosidase inhibitory activity of peels and fleshes from twelve varieties of Chaenomeles. In the results, peels of Chaenomeles contain more phenolics, flavonoids and triterpenes, and show better antioxidant activity and α-glucosidase inhibitory activity than their fleshes...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329837/the-fate-and-enantioselective-behavior-of-zoxamide-during-wine-making-process
#5
Xinglu Pan, Fengshou Dong, Na Liu, Youpu Cheng, Jun Xu, Xingang Liu, Xiaohu Wu, Zenglong Chen, Yongquan Zheng
The fate of zoxamide and its enantiomers were evaluated in detail during wine-making process. The enantiomers of zoxamide were separated and determined by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) after each processing procedure including washing, peeling, fermentation and clarification. Significant enantioselectivity was observed in all three treatments with the half-lives of R-zoxamide and S-zoxamide estimated to be 45.6 and 52.9 h in Group A, 45.0 and 52...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29328702/peeling-off-neutron-skins-from-neutron-rich-nuclei-constraints-on-the-symmetry-energy-from-neutron-removal-cross-sections
#6
T Aumann, C A Bertulani, F Schindler, S Typel
An experimentally constrained equation of state of neutron-rich matter is fundamental for the physics of nuclei and the astrophysics of neutron stars, mergers, core-collapse supernova explosions, and the synthesis of heavy elements. To this end, we investigate the potential of constraining the density dependence of the symmetry energy close to saturation density through measurements of neutron-removal cross sections in high-energy nuclear collisions of 0.4 to 1 GeV/nucleon. We show that the sensitivity of the total neutron-removal cross section is high enough so that the required accuracy can be reached experimentally with the recent developments of new detection techniques...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29326854/macular-buckling-surgery-for-retinal-detachment-associated-with-macular-hole-in-high-myopia-eye
#7
Kenan Sönmez, Ali Keleş
A 68-year-old woman presented to our clinic with a 1-month history of central scotoma and visual loss in her right eye. The best corrected visual acuity (BCVA) was hand motion in her right eye. Fundus examination showed myopic chorioretinal degeneration in association with posterior staphyloma and the retina was slightly elevated throughout the macula. Optical coherence tomography (OCT) revealed retinal detachment involving the posterior pole with a macular hole and staphyloma. The patient underwent pars plana vitrectomy, internal limiting membrane peeling, macular buckling, and perfluoropropane gas tamponade...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29324979/under-pressure-epicormic-shoots-and-traumatic-growth-zones-in-high-latitude-triassic-trees-from-east-antarctica
#8
Anne-Laure Decombeix, Rudolph Serbet, Edith L Taylor
Background and Aims: Investigating the biology of trees that were growing at high latitudes during warmer geological periods is key to understanding the functioning of both past and future forest ecosystems. The aim of this study is to report the first co-occurrence of epicormic shoots and traumatic growth zones in fossil trees from the Triassic of Antarctica and to discuss their biological and environmental implications. Methods: Permineralized woods bearing scars of epicormic shoots were collected from the Triassic Fremouw Formation in Gordon Valley, Central Transantarctic Mountains, Antarctica in 2010...
January 6, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29324930/characteristics-socioeconomic-status-and-ethnic-variations-of-primary-idiopathic-macular-hole-repair-in-vitreoretinal-centers-in-the-united-kingdom
#9
M Vasalaki, E Papavasileiou, S Velissaris, C Garnavou-Xirou, V Zygoura, O Theodorou, R Zakir, G Duguid, T Sandinha, D Steel, T L Jackson
OBJECTIVE: The purpose of this multicentre retrospective study was to investigate the characteristics and role of ethnicity and socioeconomic status amongst patients with idiopathic macular holes (IMH) and the surgical outcome. SUBJECTS AND METHOD: Consecutive patients undergoing primary IMH surgery at three vitreoretinal units in the UK (King's College Hospital, London, UK, Western Eye Hospital, London, UK, Sunderland Eye Infirmary, Sunderland, UK) between January 2007 and May 2017 were included...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324591/visualization-from-intraoperative-swept-source-microscope-integrated-optical-coherence-tomography-in-vitrectomy-for-complications-of-proliferative-diabetic-retinopathy
#10
Hesham Gabr, Xi Chen, Oscar M Zevallos-Carrasco, Christian Viehland, Alexandria Dandrige, Neeru Sarin, Tamer H Mahmoud, Lejla Vajzovic, Joseph A Izatt, Cynthia A Toth
PURPOSE: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. METHODS: In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29322634/structure-property-relations-in-carbon-nanotube-fibers-by-downscaling-solution-processing
#11
Robert J Headrick, Dmitri E Tsentalovich, Julián Berdegué, Elie Amram Bengio, Lucy Liberman, Olga Kleinerman, Matthew S Lucas, Yeshayahu Talmon, Matteo Pasquali
At the microscopic scale, carbon nanotubes (CNTs) combine impressive tensile strength and electrical conductivity; however, their macroscopic counterparts have not met expectations. The reasons are variously attributed to inherent CNT sample properties (diameter and helicity polydispersity, high defect density, insufficient length) and manufacturing shortcomings (inadequate ordering and packing), which can lead to poor transmission of stress and current. To efficiently investigate the disparity between microscopic and macroscopic properties, a new method is introduced for processing microgram quantities of CNTs into highly oriented and well-packed fibers...
January 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29322633/preclinical-evaluation-of-melanocyte-transplantation-by-chitosan-based-melanocyte-spheroid-patch-to-skin-prepared-by-controlled-sunburn-blistering
#12
Sabrina Mai-Yi Fan, Po-Hua Chen, Yu-Ting Tseng, Jin-Bon Hong, Wannhsin Chen, Tsen-Fang Tsai, Sung-Jan Lin
Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29320731/durable-interactions-of-t-cells-with-t-cell-receptor-stimuli-in-the-absence-of-a-stable-immunological-synapse
#13
Viveka Mayya, Edward Judokusumo, Enas Abu Shah, Christopher G Peel, Willie Neiswanger, David Depoil, David A Blair, Chris H Wiggins, Lance C Kam, Michael L Dustin
T cells engage in two modes of interaction with antigen-presenting surfaces: stable synapses and motile kinapses. Although it is surmised that durable interactions of T cells with antigen-presenting cells involve synapses, in situ 3D imaging cannot resolve the mode of interaction. We have established in vitro 2D platforms and quantitative metrics to determine cell-intrinsic modes of interaction when T cells are faced with spatially continuous or restricted stimulation. All major resting human T cell subsets, except memory CD8 T cells, spend more time in the kinapse mode on continuous stimulatory surfaces...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29318943/torsional-friction-behavior-of-the-contact-interface-between-the-materials-of-an-artificial-knee-joint-replacement
#14
Handong Xu, Kai Chen, Dekun Zhang, Xuehui Yang
The torsional friction behavior of the materials (CoCrMo alloy and ultra-high-molecular-weight polyethylene (UHMWPE)) that are used in artificial knee joint replacement (AKJR) were investigated under dynamic loading. The torsional friction torque, wear loss and scars and stress distribution were analyzed and compared. The results show the following: (1) the friction torque declines rapidly at the beginning of the experiments, and meanwhile, the maximum normal load and the torsional angle amplitude show very little effect on the steady value; (2) the wear loss decreases with the increased torsional angle amplitude but increases with the increased maximum normal load; additionally, as the cycle times increase, the wear rate decreases, and the wear is minimal; (3) unloading and secondary loading significantly reduce the friction and wear of the materials, and thus, patients should rest after prolonged exercise to reduce wear; (4) the margins of UHMWPE and CoCrMo are worn, and the wear mechanism is abrasive wear; (5) around the center of the UHMWPE, the surface is peeled off, and the wear mechanism is fatigue wear; and (6) in terms of the compressive stress and shear stress, the calculated results from a finite element model match the experimental results well...
January 10, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29318715/comparative-evaluation-of-skin-moisture-after-topical-application-of-10-and-30-lactobionic-acid
#15
Barbara Algiert-Zielińska, Paulina Mucha, Helena Rotsztejn
BACKGROUND: Dry skin is characterized by symptoms such as itching, redness, excessive exfoliation. These symptoms cause discomfort and contribute to secondary bacterial infections. Dry skin treatments are based on topical applications of various formulations. Among many of them are polyhydroxy acids, which recently gained more attention. AIMS: The aim of this study was a comparative assessment of hydration level (corneometric) after application of lactobionic acid (LA) in the form of peel at concentrations of 10% and 30%...
January 9, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29313727/polymethoxylated-flavones-from-orange-peels-inhibit-cell-proliferation-in-a-3d-cell-model-of-human-colorectal-cancer
#16
Inês Silva, Marta F Estrada, Carolina V Pereira, Andreia Bento da Silva, Maria R Bronze, Paula M Alves, Catarina M M Duarte, Catarina Brito, Ana Teresa Serra
Polymethoxylated flavones (PMFs) have been recognized to inhibit colorectal cancer proliferation through various mechanisms, however most of these studies have been performed on cells grown as monolayers that present limitations in mimicking the 3D tumor architecture and microenvironment. The main aim of this study was to investigate the anticancer potential of an orange peel extract (OPE) enriched in PMFs in a 3D cell model of colorectal cancer. The OPE was developed by supercritical fluid extraction and the anticancer effect was evaluated in HT29 spheroids cultures in a stirred-tank based system...
January 9, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29312764/ectopic-thymoma-managed-by-neck-dissection-video-assisted-thoracoscopic-thymectomy
#17
John K Peel, Eitan Prisman, Tony L Ng, Anna L McGuire
Ectopic thymoma in the neck is a rare phenomenon, with fewer than 20 cases reported worldwide. Evidence for management of ectopic thymoma comes from literature for mediastinal thymoma despite clinical features that distinguish the two. Here we present a case of a 31-year-old female with an asymptomatic neck mass who was found to have an ectopic cervical thymoma with concomitant mediastinal thymic hyperplasia. The decision was made to perform a left-sided neck dissection and a video-assisted thoracoscopic surgery (VATS) thymectomy...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29302908/heavy-metals-in-handloom-dyeing-effluents-and-their-biosorption-by-agricultural-byproducts
#18
Kamrun Nahar, Md Abul Khair Chowdhury, Md Akhter Hossain Chowdhury, Afzal Rahman, K M Mohiuddin
The Madhabdi municipality in the Narsingdi district of Bangladesh is a well-known area for textile, handloom weaving, and dyeing industries. These textile industries produce a considerable amount of effluents, sewage sludge, and solid waste materials every day that they directly discharge into surrounding water bodies and agricultural fields. This disposal poses a serious threat to the overall epidemic and socio-economic pattern of the locality. This research entailed the collection of 34 handloom-dyeing effluent samples from different handloom-dyeing industries of Madhabdi, which were then analyzed to determine the contents of the heavy metals iron (Fe), zinc (Zn), copper (Cu), chromium (Cr), manganese (Mn), lead (Pb), and cadmium (Cd)...
January 4, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29302729/color-change-after-paramedical-pigmentation-of-the-nipple-areola-complex
#19
Shoichi Tomita, Katsuya Mori, Takeshi Miyawaki
BACKGROUND: Reconstruction of the nipple-areola complex is the final process in breast reconstruction. Local flaps and paramedical pigmentation is one of the major procedures for this. However, fading after paramedical pigmentation leads to a color difference between the selected pigment and its color in the skin. The aim of this study is to make a proposition in color choice of paramedical pigmentation for nipple-areola complex. METHODS: Our research focused on investigating the color changes over time after unilateral nipple-areola complex reconstruction using paramedical pigmentation in 25 patients to propose suitable color selections...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29300247/the-current-surgical-management-of-large-recurrent-or-persistent-macular-holes
#20
Alex L C Tam, Peng Yan, Nicola Y Gan, Wai-Ching Lam
PURPOSE: To evaluate the current surgical options available for the management of large (>400 μm), recurrent, or persistent macular holes (MHs). METHODS: A review of the literature was performed, focusing on the epidemiology, pathophysiology, diagnosis, and surgical treatments of large, recurrent, or persistent MHs. Based on this review, a comprehensive overview was provided regarding the topic of large, recurrent, or persistent MHs and focused on recent surgical management updates...
January 3, 2018: Retina
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