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areata alopecia

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https://www.readbyqxmd.com/read/29135509/unilesional-follicular-mycosis-fungoides-report-of-6-cases-and-review-of-the-literature
#1
Cynthia M Magro, Gladys H Telang, Shabnam Momtahen
Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion...
October 24, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29132855/willingness-to-pay-and-quality-of-life-in-alopecia-areata
#2
Jean-Phillip Okhovat, Tristan Grogan, Lewei Duan, Carolyn Goh
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29128463/objective-outcome-measures-collecting-meaningful-data-on-alopecia-areata
#3
Elise A Olsen, Janet Roberts, Leonard Sperling, Antonella Tosti, Jerry Shapiro, Amy McMichael, Wilma Bergfeld, Valerie Callender, Paradi Mirmirani, Ken Washenik, David Whiting, George Cotsarelis, Maria Hordinsky
BACKGROUND: Although alopecia areata is a common disorder, it has no FDA approved treatment and evidence-based therapeutic data is lacking. OBJECTIVE: To develop guidelines for the diagnosis, evaluation, assessment, response criteria and endpoints for alopecia areata. METHODS: Literature review and expert opinion of a group of dermatologists specializing in hair disorders. RESULTS: Standardized methods of assessing and tracking hair loss and growth including new scoring techniques, response criteria and endpoints in alopecia areata are presented...
November 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29128459/successful-treatment-of-moderate-to-severe-alopecia-areata-improves-health-related-quality-of-life
#4
Lucy Y Liu, Brittany G Craiglow, Brett A King
No abstract text is available yet for this article.
November 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29118520/utilization-of-mental-health-resources-and-complementary-and-alternative-therapies-for-alopecia-areata-a-u-s-survey
#5
Salman T Hussain, Arash Mostaghimi, Paul J Barr, Jeremiah R Brown, Cara Joyce, Kathie P Huang
Background: The efficacy of traditional medical treatments for alopecia areata (AA) is limited, leading some to pursue alternative treatments. The utilization and nature of these treatments are unclear. Objective: To assess the extent to which patients with AA pursue alternative treatments and to characterize these treatments. Methods: A 13-item electronic survey was E-mailed by the National Alopecia Areata Foundation (NAAF) to their patient database and shared on the NAAF social media to individuals with AA...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29118519/detection-of-tumor-necrosis-factor-alpha-in-nonlesional-tissues-of-alopecia-areata-patients-a-prove-for-a-systemic-disease
#6
Yasser Mostsfa Gohary, Dina Sabry Abdel Fattah
Introduction: The pathogenesis of alopecia areata (AA) remains incompletely understood. Different cytokines may play a role in AA. Tumor necrosis factor-alpha (TNF-α) has been shown to be inhibitory to hair follicle growth in in vitro studies suggesting that it may play an important role in AA. This study was conducted to assess the presence of TNF-α in lesional and nonlesional skin of AA, to review its possible role in AA, and to show whether AA is a systemic or localized disease by comparing the level of TNF-α between lesional and nonlesional skin biopsies of the patients...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29118518/insignificant-correlation-between-thyroid-hormone-and-antithyroid-peroxidase-antibodies-in-alopecia-areata-patients-in-northern-rajasthan
#7
Gagandeep Kaur, C M Kuldeep, Puneet Bhargava, Deepak Kumar Mathur, Sonam Sharda, Pulkit Chaturvedi
Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0.2% in general population and 7-30 cases per 1000 dermatological patients. The etiology of AA still remains uncertain; however, genetic or environmental factor and autoimmunity are claimed responsible for it. Various autoimmune diseases, such as Hashimoto's thyroiditis, diabetes mellitus, vitiligo, and lupus erythematosus, have been reported in association with AA...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29108908/tofacitinib-2-ointment-a-topical-janus-kinase-inhibitor-for-the-treatment-of-alopecia-areata-a-pilot-study-of-10-patients
#8
Lucy Y Liu, Brittany G Craiglow, Brett A King
No abstract text is available yet for this article.
November 3, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29108907/subclinical-sensitization-with-diphenylcyclopropenone-is-sufficient-for-the-treatment-of-alopecia-areata-retrospective-analysis-of-159-cases
#9
Sung Jay Choe, Solam Lee, Long Quan Pi, Dong In Keum, Chung Hyeok Lee, Beom Jun Kim, Won-Soo Lee
BACKGROUND: Contact immunotherapy with diphenylcyclopropenone (DPCP) is presently considered the treatment of choice for extensive alopecia areata (AA). However, a major concern with contact immunotherapy is that it causes various adverse effects (AEs) that contribute to discontinuation of treatment. OBJECTIVE: We investigated whether a modified DPCP treatment protocol can promote hair regrowth with fewer AEs. METHODS: All patients were sensitized with 0...
November 3, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29105836/pediatric-severity-of-alopecia-tool
#10
Elena Bernardis, Jonathan Nukpezah, Ping Li, Theresa Christensen, Leslie Castelo-Soccio
The Severity of Alopecia Tool serves as a tool for alopecia research and a clinical guideline for following progression of disease. The original Severity of Alopecia Tool score does not take into account pediatric age groups. As new clinical trials for alopecia areata include more children, a more accurate tool should be available for this population. By collecting images from patients 2-21 years of age and aligning the hair-bearing regions of the scalp, we created an adaptation of the Severity of Alopecia Tool for scoring hair loss percentage of the top, parietal, and occipital scalp in individuals 2-5, 6-11, and 12-21 years of age...
November 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29103820/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#11
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
November 3, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29083474/alopecia-areata-is-characterized-by-expansion-of-circulating-th2-tc2-th22-within-the-skin-homing-and-systemic-t-cell-populations
#12
Tali Czarnowicki, Helen Y He, Huei-Chi Wen, Peter W Hashim, John K Nia, Kunal Malik, Yeriel Estrada, Grace W Kimmel, Mark Taliercio, James G Krueger, Emma Guttman-Yassky
BACKGROUND: Characterizing blood profile of alopecia areata (AA) is not only important for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+) ) vs. systemic (CLA(-) ) "polar" CD4(+) and CD8(+) and activated T-cell subsets in AA vs. AD and control blood. METHODS: Flow cytometry was used to measure IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines in CD4(+) and CD8(+) T-cells...
October 30, 2017: Allergy
https://www.readbyqxmd.com/read/29080678/genome-wide-microrna-analysis-implicates-mir-30b-d-in-the-etiology-of-alopecia-areata
#13
Aylar Tafazzoli, Andreas J Forstner, David Broadley, Andrea Hofmann, Silke Redler, Lynn Petukhova, Kathrin A Giehl, Roland Kruse, Bettina Blaumeiser, Markus Böhm, Marta Bertolini, Alfredo Rossi, Natalie Garcia Bartels, Gerhard Lutz, Hans Wolff, Ulrike Blume-Peytavi, Hermona Soreq, Angela M Christiano, Natalia V Botchkareva, Markus M Nöthen, Regina C Betz
Alopecia areata (AA) is one of the most common forms of human hair loss. Although genetic studies have implicated autoimmune processes in AA etiology, understanding of the etiopathogenesis is incomplete. Recent research has implicated microRNAs, a class of small non-coding RNAs, in diverse autoimmune diseases. To date, no study has investigated the role of microRNAs in AA. In the present study, gene-based analyses were performed for microRNAs using data of the largest genome-wide association (GWA) meta-analysis of AA to date...
October 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29045013/is-there-a-relationship-between-melanocytes-and-sensorineural-hearing-loss-clinical-evaluation-of-fifthy-one-alopecia-areata-patients
#14
Hasan Emre Koçak, Ayşe Şermin Filiz Acıpayam, Harun Acıpayam, Bilgen Çakıl Erdoğan, Nimet Yeşim Yıldız, Levent Küfeciler, Mustafa Suphi Elbistanlı, Kamil Hakan Kaya
Melanocytes are located in both the cochlea and vestibular organ of the inner ear. They are present in the hearing organ, in the intermediate layer of stria vascularis in the cochlea. The most important task of the stria vascularis is to provide the endolymph production necessary for normal hearing levels, especially high K(+) concentration, and to protect the positive endocochlear potential. Specifically, intermediate layer melanocytes express ionic channels, such as inwardly rectifying K+ channels and voltage-dependent outwardly rectifying K+...
October 17, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29034491/oral-tofacitinib-a-promising-treatment-in-atopic-dermatitis-alopecia-areata-and-vitiligo
#15
M Vu, C Heyes, S J Robertson, G A Varigos, G Ross
No abstract text is available yet for this article.
October 16, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29029913/lack-of-an-association-between-alopecia-areata-and-visceral-or-hematopoietic-cancers
#16
Ruzica Z Conic, Pooja Rambhia, Natasha Atanaskova-Mesinkovska, Melissa Piliang, Wilma Bergfeld
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29029912/prevalence-of-pediatric-alopecia-areata-among-572-617-dermatology-patients
#17
Chauncey C Caldwell, Sami K Saikaly, Robert P Dellavalle, James A Solomon
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29029911/oral-tofacitinib-monotherapy-in-korean-patients-with-refractory-moderate-to-severe-alopecia-areata-a-case-series
#18
Hyun-Sun Park, Min-Woo Kim, Ji Su Lee, Hyun-Sun Yoon, Chang-Hun Huh, Ohsang Kwon, Soyun Cho
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29028121/lupus-like-cutaneous-reaction-following-pembrolizumab-an-immune-related-adverse-event-associated-with-anti-pd-1-therapy
#19
Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, Emily Y Chu
PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata, and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29020475/association-khellin-and-308-nm-excimer-lamp-in-the-treatment-of-severe-alopecia-areata-in-a-child
#20
Samy Fenniche, Houda Hammami, Anissa Zaouak
Alopecia areata (AA) is an autoimmune inflammatory disorder of hair, characterized by non-scarring hair loss. 308-nm Excimer lamp (EL) has been reported as one effective modality in the treatment of AA. Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with UVA. We evaluated the efficacy and safety of a combination of topical khellin and 308-nm EL in the treatment of a refractory ophiasic AA (OAA), of 1-year evolution, in a 5-year-old boy...
October 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
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