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Masked Hypertension

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https://www.readbyqxmd.com/read/29650545/regulation-of-blood-pressure-by-targeting-ca-v-1-2-galectin-1-protein-interaction
#1
Zhenyu Hu, Guang Li, Jiong-Wei Wang, Suet Yen Chong, Dejie Yu, Xiaoyuan Wang, Jia Lin Soon, Mui Cheng Liang, Yuk Peng Wong, Na Huang, Henry M Colecraft, Ping Liao, Tuck Wah Soong
Background -L-type CaV 1.2 channels play crucial roles in regulation of blood pressure. Galectin-1 (Gal-1), has been reported to bind to the I-II loop of CaV 1.2 channels to reduce their current density. However, the mechanistic understanding for the down-regulation of CaV 1.2 channels by Gal-1, and whether Gal-1 plays a direct role in blood pressure regulation remain unclear. Methods - In vitro experiments involving co-IP, western blot, patch-clamp recordings, immunohistochemistry and pressure myography were used to evaluate the molecular mechanisms by which Gal-1 down-regulates CaV 1...
April 12, 2018: Circulation
https://www.readbyqxmd.com/read/29616152/sustained-dorzolamide-release-prevents-axonal-and-retinal-ganglion-cell-loss-in-a-rat-model-of-iop-glaucoma
#2
Ian Pitha, Elizabeth C Kimball, Ericka N Oglesby, Mary Ellen Pease, Jie Fu, Julie Schaub, Yoo-Chun Kim, Qi Hu, Justin Hanes, Harry A Quigley
Purpose: To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. Methods: We injected either DPP or control microparticles intravitreally in rats. Two days later, unilateral ocular hypertension was induced by translimbal, diode laser treatment by a surgeon masked to treatment group. IOP and clinical exams were performed until sacrifice 6 weeks after laser treatment...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29611838/white-coat-uncontrolled-hypertension-masked-uncontrolled-hypertension-and-true-uncontrolled-hypertension-phonetic-and-mnemonic-terms-for-treated-hypertension-phenotypes
#3
José R Banegas, Luis M Ruilope, Bryan Williams
No abstract text is available yet for this article.
February 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29602406/hypertension-in-adults-with-type-2-diabetes-a-review-of-blood-pressure-measurement-methods-targets-and-therapy
#4
REVIEW
Lyne Cloutier, Maxime Lamarre-Cliche
Hypertension occurs in more than two-thirds of patients with type 2 diabetes. In a retrospective analysis of a Framingham cohort, high blood pressure was associated with a 72% increase in the risk for all-cause death and a 57% increment in the risk for any cardiovascular disease event, making hypertension the strongest driver of cardiovascular outcomes in individuals with diabetes. One of the key aspects of hypertension management is the correct measurement of blood pressure; various types of monitoring in both clinic and ambulatory settings are reviewed here...
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29601413/masked-hypertension-and-kidney-function-decline-the-jackson-heart-study
#5
Stanford Mwasongwe, Yuan-I Min, John N Booth, Ronit Katz, Mario Sims, Adolfo Correa, Bessie Young, Paul Muntner
BACKGROUND: Hypertension diagnosed by blood pressure (BP) measured in the clinic is associated with rapid kidney function decline (RKFD) and incident chronic kidney disease (CKD). The extent to which hypertension defined using out-of-clinic BP measurements is associated with these outcomes is unclear. METHODS: We evaluated the association of any masked hypertension (daytime SBP/DBP ≥ 135/85 mmHg, night-time SBP/DBP ≥ 120/70 mmHg or 24-h SBP/DBP ≥ 130/80 mmHg) with RKFD and incident CKD among 676 African-Americans in the Jackson Heart Study with clinic-measured SBP/DBP less than 140/90 mmHg who completed ambulatory BP monitoring in 2000-2004...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29601412/left-ventricular-mass-independently-associates-with-masked-hypertension-in-young-healthy-adults-the-african-predict-study
#6
Nare P Sekoba, Ruan Kruger, Pieter Labuschagne, Aletta E Schutte
OBJECTIVE: Masked hypertension is reportedly common in young adults. However, it is unknown if these masked hypertensive individuals already present with organ damage. We determined whether a relationship exists between left ventricular structure and function, and masked hypertension in young healthy adults. METHODS: In this cross-sectional study, we included 774 black and white men and women (aged 20-30 years) who had successful ambulatory blood pressure monitoring readings (>70% valid readings) and valid echocardiography done...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29548933/impact-of-masked-hypertension-on-diabetic-nephropathy-in-patients-with-type-ii-diabetes-a-kamogawa-hbp-study
#7
Emi Ushigome, Chikako Oyabu, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Naoto Nakamura, Yohei Oda, Mai Asano, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
The prognostic significance of masked hypertension (MH) on the progression of diabetic nephropathy among patients with type II diabetes is not well documented. We examined the relationship between clinic systolic blood pressure (SBP) and morning home SBP measurements and progression to macroalbuminuria in patients with type II diabetes. We analyzed prospective cohort study data from 712 patients with type II diabetes. We classified the patients into the following four groups according to their clinic (130 mm Hg) and home (125 mm Hg) SBP measurements: controlled blood pressure group, white-coat hypertension group, MH group, and sustained hypertension (SH) group...
March 1, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29530989/reliability-of-single-office-blood-pressure-measurements
#8
Thilo Burkard, Michael Mayr, Clemens Winterhalder, Licia Leonardi, Jens Eckstein, Annina Salome Vischer
OBJECTIVES: Standard operating procedures for office blood pressure measurement (OBPM) vary greatly between guidelines and studies. We aimed to compare the difference between a single OBPM and the mean of the three following measurements. Further, we studied how many patients with possible hypertension may be missed due to short-term masked hypertension (STMH) and how many might be overdiagnosed due to short-term white coat hypertension (STWCH). DESIGN AND SETTING: In this cross-sectional, single-centre trial, 1000 adult subjects were enrolled...
March 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29510226/exploring-topical-anti-glaucoma-medication-effects-on-the-ocular-surface-in-the-context-of-the-current-understanding-of-dry-eye
#9
Aaron B C Wong, Michael T M Wang, Kevin Liu, Zak J Prime, Helen V Danesh-Meyer, Jennifer P Craig
PURPOSE: To assess tear film parameters, ocular surface characteristics, and dry eye symptomology in patients receiving topical anti-glaucoma medications. METHODS: Thirty-three patients with a diagnosis of open angle glaucoma or ocular hypertension, receiving unilateral topical anti-glaucoma medication for at least 6 months, were recruited in a cross-sectional, investigator-masked, paired-eye comparison study. Tear film parameters, ocular surface characteristics, and dry eye symptomology of treated and fellow eyes were evaluated and compared...
March 3, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29507944/effect-of-standard-vs-intensive-blood-pressure-control-on-cerebral-blood-flow-in-small-vessel-disease-the-preserve-randomized-clinical-trial
#10
Iain D Croall, Daniel J Tozer, Barry Moynihan, Usman Khan, John T O'Brien, Robin G Morris, Victoria C Cambridge, Thomas R Barrick, Andrew M Blamire, Gary A Ford, Hugh S Markus
Importance: Blood pressure (BP) lowering is considered neuroprotective in patients with cerebral small vessel disease; however, more intensive regimens may increase cerebral hypoperfusion. This study examined the effect of standard vs intensive BP treatment on cerebral perfusion in patients with severe small vessel disease. Objective: To investigate whether standard vs intensive BP lowering over 3 months causes decreased cerebral perfusion in small vessel disease...
March 5, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29505772/effect-of-ibuprofen-versus-acetaminophen-on-postpartum-hypertension-in-preeclampsia-with-severe-features-a-double-masked-randomized-controlled-trial
#11
Nathan R Blue, Cristina Murray-Krezan, Shana Drake-Lavelle, Daniel Weinberg, Bradley D Holbrook, Vivek R Katukuri, Lawrence Leeman, Ellen L Mozurkewich
BACKGROUND: Non-steroidal anti-inflammatory drug use has been shown to increase blood pressure in non-pregnant adults. Because of this, the American College of Obstetricians and Gynecologists suggests avoiding their use in women with postpartum hypertension; however, evidence to support this recommendation is lacking. OBJECTIVES: Our goal was to test the hypothesis that non-steroidal anti-inflammatory drugs, such as ibuprofen, adversely affect postpartum blood pressure control in women with preeclampsia with severe features...
March 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29501627/orthostatic-hypertension-as-a-risk-factor-for-age-related-macular-degeneration-evidence-from-the-irish-longitudinal-study-on-ageing
#12
Bláithín Ní Bhuachalla, Christine A McGarrigle, Neil O'Leary, Kwadwo Owusu Akuffo, Tunde Peto, Stephen Beatty, Rose Anne Kenny
PURPOSE: Age related macular degeneration (AMD) is a leading cause of irreversible visual loss in developed countries. It is associated with vascular risk factors including hypertension. Dysregulated blood pressure (BP) behaviour including orthostatic hypertension (OHTN), hypotension (OH) and BP variability (BPV) are associated with end-organ damage, particularly in the brain. We investigated if abnormal orthostatic BP (OBP) was a risk factor for AMD, for which a vascular aetiology is implicated...
February 28, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29499873/efficacy-of-self-monitored-blood-pressure-with-or-without-telemonitoring-for-titration-of-antihypertensive-medication-tasminh4-an-unmasked-randomised-controlled-trial
#13
Richard J McManus, Jonathan Mant, Marloes Franssen, Alecia Nickless, Claire Schwartz, James Hodgkinson, Peter Bradburn, Andrew Farmer, Sabrina Grant, Sheila M Greenfield, Carl Heneghan, Susan Jowett, Una Martin, Siobhan Milner, Mark Monahan, Sam Mort, Emma Ogburn, Rafael Perera-Salazar, Syed Ahmar Shah, Ly-Mee Yu, Lionel Tarassenko, F D Richard Hobbs
BACKGROUND: Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place of telemonitoring over self-monitoring alone is unclear. The TASMINH4 trial aimed to assess the efficacy of self-monitored blood pressure, with or without telemonitoring, for antihypertensive titration in primary care, compared with usual care. METHODS: This study was a parallel randomised controlled trial done in 142 general practices in the UK, and included hypertensive patients older than 35 years, with blood pressure higher than 140/90 mm Hg, who were willing to self-monitor their blood pressure...
February 27, 2018: Lancet
https://www.readbyqxmd.com/read/29483139/bp-measurement-techniques-what-they-mean-for-patients-with-kidney-disease
#14
REVIEW
George Thomas, Paul E Drawz
Patients with CKD typically have hypertension. Manual BP measurement in the office setting was used to define hypertension, establish eligibility, and assess BP targets in the epidemiologic studies and early randomized, controlled trials that inform current management of hypertension. Use of automated oscillometric devices has largely replaced manual BP measurement in the office and clinical trials. These newer devices may reduce the white coat effect and facilitate guideline-adherent measurement protocols...
February 26, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29477665/adjuvant-vemurafenib-in-resected-braf-v600-mutation-positive-melanoma-brim8-a-randomised-double-blind-placebo-controlled-multicentre-phase-3-trial
#15
Michele Maio, Karl Lewis, Lev Demidov, Mario Mandalà, Igor Bondarenko, Paolo A Ascierto, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant R Goodman, Brian Simmons, Chenglin Ye, Yibing Yan, Dirk Schadendorf
BACKGROUND: Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC-III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAFV600 mutation-positive melanoma. METHODS: BRIM8 was a phase 3, international, double-blind, randomised, placebo-controlled study that enrolled 498 adults (aged ≥18 years) with histologically confirmed stage IIC-IIIA-IIIB (cohort 1) or stage IIIC (cohort 2) BRAFV600 mutation-positive melanoma that was fully resected...
February 21, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29472296/brain-injury-lesion-imaging-using-preconditioned-quantitative-susceptibility-mapping-without-skull-stripping
#16
S Soman, Z Liu, G Kim, U Nemec, S J Holdsworth, K Main, B Lee, S Kolakowsky-Hayner, M Selim, A J Furst, P Massaband, J Yesavage, M M Adamson, P Spincemallie, M Moseley, Y Wang
BACKGROUND AND PURPOSE: Identifying cerebral microhemorrhage burden can aid in the diagnosis and management of traumatic brain injury, stroke, hypertension, and cerebral amyloid angiopathy. MR imaging susceptibility-based methods are more sensitive than CT for detecting cerebral microhemorrhage, but methods other than quantitative susceptibility mapping provide results that vary with field strength and TE, require additional phase maps to distinguish blood from calcification, and depict cerebral microhemorrhages as bloom artifacts...
February 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29469601/the-effects-of-netarsudil-ophthalmic-solution-on-aqueous-humor-dynamics-in-a-randomized-study-in-humans
#17
Arash Kazemi, Jay W McLaren, Casey C Kopczynski, Theresa G Heah, Gary D Novack, Arthur J Sit
PURPOSE: Netarsudil, an inhibitor of Rho kinase and a norepinephrine transporter, has been shown to lower elevated intraocular pressure (IOP) in controlled studies of patients with open-angle glaucoma and ocular hypertension, and in healthy volunteers. The mechanism of this ocular hypotensive effect in humans is unknown. METHODS: The objective of this study was to evaluate the effect of netarsudil 0.02% on aqueous humor dynamics (AHD) parameters. In this double-masked, vehicle-controlled, paired-eye comparison study, 11 healthy volunteers received topical netarsudil ophthalmic solution 0...
February 22, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29459219/home-blood-pressure-guided-antihypertensive-therapy-in-chronic-kidney-disease-more-data-are-needed
#18
EDITORIAL
Panagiotis I Georgianos, Eleni Champidou, Vassilios Liakopoulos, Elias V Balaskas, Pantelis E Zebekakis
In the era of newly introduced hypertension guidelines recommending lower blood pressure (BP) targets for drug-treated hypertensives, the necessity for optimized management of hypertension becomes even more urgent. The concept of home BP-guided antihypertensive therapy is for long suggested as a simple and feasible approach to improve BP control rates and optimize the management of hypertension. Home BP-guided antihypertensive therapy is particularly applicable to hypertensives with chronic kidney disease (CKD) for several reasons including the following: (1) difficult-to-control BP and high BP variability in the CKD setting; (2) poor accuracy of office BP in determining hypertension control status and detecting "white-coat" and "masked" hypertension; (3) poor value of routine office BP recordings in predicting the longitudinal progression of target-organ damage; and (4) superiority of home BP over office BP recordings in prognosticating the risk of incident end-stage renal disease or death...
February 10, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29447435/asymmetric-dimethylarginine-levels-are-associated-with-augmentation-index-across-na%C3%A3-ve-untreated-patients-with-different-hypertension-phenotypes
#19
Eugenia Gkaliagkousi, Eleni Gavriilaki, Areti Triantafyllou, Barbara Nikolaidou, Panagiota Anyfanti, Nikolaos Koletsos, Anastasios Vamvakis, Konstantina Dipla, Antonios Lazaridis, Stella Douma
Asymmetric dimethylarginine (ADMA) is a robust marker of endothelial dysfunction in patients with essential hypertension. We investigated ADMA levels and their association with vascular damage in untreated hypertension. We enrolled consecutive patients with untreated, recently diagnosed hypertension and age-matched normotensive individuals. 24-hour blood pressure, central hemodynamics, and arterial stiffness were recorded. A total of 311 individuals were studied: 165 with essential hypertension, 50 with masked hypertension, 25 with white-coat hypertension, and 71 normotensive individuals...
February 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29437895/blood-pressure-profile-1-year-after-severe-preeclampsia
#20
Laura Benschop, Johannes J Duvekot, Jorie Versmissen, Valeska van Broekhoven, Eric A P Steegers, Jeanine E Roeters van Lennep
Preeclampsia increases the long-term risk of cardiovascular disease, possibly through occurrence of hypertension after delivery, such as masked hypertension, night-time hypertension, and an adverse systolic night-to-day blood pressure (BP) ratio. These types of hypertension are often unnoticed and can only be detected with ambulatory BP monitoring (ABPM). We aimed to determine hypertension prevalence and 24-hour BP pattern with ABPM and office BP measurements in women 1 year after severe preeclampsia. This is a retrospective cohort study...
March 2018: Hypertension
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