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Geak Poh Tan, Nigel McArdle, Satvinder Singh Dhaliwal, Jane Douglas, Clare Siobhan Rea, Bhajan Singh
Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m-2) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%)...
January 1, 2018: Chronic Respiratory Disease
Kelly J Shields, Changgong Wu
Differential proteomic analysis (comparative quantitative proteomics) is a robust quantitative technique used to detect and identify the proteome of selected tissues. The expression levels (upregulated vs. downregulated) of proteins in tissue samples that differ by experimental design or anatomic location are determined by a series of assays including (1) 2D difference gel electrophoresis (2D-DiGE), (2) protein spot picking based on a priori thresholds, (3) Mass Spectrometry, and (4) follow-up Western Blot for antibody validation (Chen et al...
October 10, 2017: Methods in Molecular Biology
Jacob Eliet, Philippe Gaudard, Norddine Zeroual, Philippe Rouvière, Bernard Albat, Marc Mourad, Pascal H Colson
Peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO) exposes the patient to a pulmonary blood flow bypass and a left ventricle afterload increase. Impella, a catheter-mounted microaxial rotary pump, has been proposed for left ventricle (LV) unloading in combination with VA ECMO. In order to assess the effect of Impella on pulmonary flow and LV preload, we checked Doppler pulmonary artery velocity-time integral (pVTI) and LV diastolic diameter (LVED) by transesophageal echocardiography and end-tidal carbon dioxide (EtCO2) during a step-by-step increase in Impella flow (Impella ramp test)...
September 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Lisa Borkner, Katarzyna M Sitnik, Iryna Dekhtiarenko, Ann-Kathrin Pulm, Ronny Tao, Ingo Drexler, Luka Cicin-Sain
Experimental CMV-based vaccine vectors expressing a single MHC class I-restricted high-avidity epitope provided strong, T cell-dependent protection against viruses or tumors. In this study we tested the low-avidity epitope KCSRNRQYL, and show that a mouse CMV (MCMV) vector provides complete immune control of recombinant vaccinia virus expressing the same epitope if KCSRNRQYL is expressed within the immediate-early MCMV gene ie2 The same epitope expressed within the early M45 gene provided no protection, although MCMV vectors expressing the high-avidity epitope SSIEFARL induced protective immunity irrespective of gene expression context...
September 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Javier Santos-Moreno, Alexandra East, Ingrid Guilvout, Nathalie Nadeau, Peter J Bond, Guy Tran Van Nhieu, Olivera Francetic
Bacterial type 2 secretion systems (T2SS), type 4 pili, and archaeal flagella assemble fibres from initially membrane-embedded pseudopilin and pilin subunits. Fibre subunits are made as precursors with positively charged N-terminal anchors, whose cleavage via the prepilin peptidase, essential for pilin membrane extraction and assembly, is followed by N-methylation of the mature (pseudo)pilin N terminus. The conserved Glu residue at position 5 (E5) of mature (pseudo)pilins is essential for assembly. Unlike T4 pilins, where E5 residue substitutions also abolish N-methylation, the E5A variant of T2SS pseudopilin PulG remains N-methylated but is affected in interaction with the T2SS component PulM...
June 2, 2017: Journal of Molecular Biology
Na Yu, Yi-Tian Sun, Xin-Ming Su, Miao He, Bing Dai, Jian Kang
Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease. However, the pathogenesis remains to be fully elucidated. Melatonin is secreted by the pineal gland, it has a strong antioxidant effect, and exerts an anti-fibrosis effect. Whether melatonin attenuates pulm -onary fibrosis by inhibiting epithelial‑mesenchymal transition (EMT) requires further research. The present study aimed to investigate whether melatonin prevents transforming growth factor‑β1 (TGF‑β1)‑induced EMT and underlying signaling pathways using reverse transcription‑quantitative polymerase chain reaction, western blot analysis and immunofluorescence...
December 2016: Molecular Medicine Reports
Masanori Yokoba, Tsuyoshi Ichikawa, Akira Takakura, Naohito Ishii, Yoshifumi Kurosaki, Yuya Yamada, Tomoaki Tsukushi, Noriyuki Masuda, Paul A Easton, Masato Katagiri
No abstract text is available yet for this article.
December 2016: Pulmonary Pharmacology & Therapeutics
Mangayarkarasi Nivaskumar, Javier Santos-Moreno, Christian Malosse, Nathalie Nadeau, Julia Chamot-Rooke, Guy Tran Van Nhieu, Olivera Francetic
Type II secretion systems (T2SSs) promote secretion of folded proteins playing important roles in nutrient acquisition, adaptation and virulence of Gram-negative bacteria. Protein secretion is associated with the assembly of type 4 pilus (T4P)-like fibres called pseudopili. Initially membrane embedded, pseudopilin and T4 pilin subunits share conserved transmembrane segments containing an invariant Glu residue at the fifth position, E5. Mutations of E5 in major T4 pilins and in PulG, the major pseudopilin of the Klebsiella T2SS abolish fibre assembly and function...
September 2016: Molecular Microbiology
C A Guevara, E Parody, A F Aguirre
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
E Parody, C A Guevara, A F Aguirre
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Ludwig Kuntz, Jannis Pulm, Michael Wittland
BACKGROUND: Dynamic and complex transformations in the hospital market increase the relevance of good corporate governance. However, hospital performance and the characteristics of supervisory boards differ depending on ownership. The question therefore arises whether hospital owners can influence performance by addressing supervisory board characteristics. PURPOSE: The objective of this study is to explain differences in the financial performance of hospitals with regard to ownership by studying the size and composition of supervisory boards...
April 2016: Health Care Management Review
Mark J Haykowsky, Corey R Tomczak, Jessica M Scott, D Ian Paterson, Dalane W Kitzman
This mini-review summarizes the literature regarding the mechanisms of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction (HFREF and HFPEF, respectively). Evidence to date suggests that the reduced peak pulmonary oxygen uptake (pulm V̇o₂) in patients with HFREF compared with healthy controls is due to both central (reduced convective O₂ transport) and peripheral factors (impaired skeletal muscle blood flow, decreased diffusive O₂ transport coupled with abnormal skeletal morphology, and metabolism)...
September 15, 2015: Journal of Applied Physiology
Magdalena Kocur, Reiner Schneider, Ann-Kathrin Pulm, Jens Bauer, Sonja Kropp, Michael Gliem, Jens Ingwersen, Norbert Goebels, Judith Alferink, Timour Prozorovski, Orhan Aktas, Stefanie Scheu
INTRODUCTION: Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) leading to progressive neurological disability. Interferon β (IFNβ) represents a standard treatment for relapsing-remitting MS and exogenous administration of IFNβ exhibits protective effects in experimentally induced CNS autoimmunity. Also, genetic deletion of IFNβ in mice leads to an aggravation of disease symptoms in the MS model of experimental autoimmune encephalomyelitis (EAE)...
2015: Acta Neuropathologica Communications
Andreas Rolf, Johannes Rixe, Won K Kim, Johannes Börgel, Helge Möllmann, Holger M Nef, Christoph Liebetrau, Thorsten Kramm, Stefan Guth, Gabriele A Krombach, Eckhard Mayer, Christian W Hamm
BACKGROUND: The aim of the study was to characterize RV adaptation to varying loading conditions in patients with chronic thromboembolic hypertension (CTEPH) before and after pulmonary endarterectomy (PEA). Nearly 4% of patients with pulmonary embolism develop CTEPH. PEA offers a cure with excellent outcome. By use of cardiovascular magnetic resonance (CMR) combined with hemodynamic measurements pulmonary arterial elastance (Ea-pulm_i), end-systolic right ventricular elastance (Ees-RV_i) and ventriculo-arterial coupling (Ea-pulm_i/Ees-RV_i) can be studied before and after PEA...
December 5, 2014: Journal of Cardiovascular Magnetic Resonance
Jonathan P Metters, Dimitrios K Kampouris, Craig E Banks
It has recently been demonstrated that 2-aminoacetophenone (2-AA) is a chemical indicator in exhaled air/breath of Pseudomonas aeruginosa infection associated with progressive life threatening decline of lung function in cystic fibrosis sufferers [Scott-Thomas et al., BMC Pulm. Med., 2010, 10, 56]. Currently the detection of 2-AA involves laboratory based instrumentation such as mass spectrometry and a hand-held point-of-care type breath device would be ideal in providing real-time results within seconds to accelerate patient care decision-making processes...
August 21, 2014: Analyst
Vahid Samavati, Farshid Skandari
The extraction of gum from Assyrian pulm fruit (APH) was performed by microwave-assisted extraction technique. A Box-Behnken design (BBD) was applied to evaluate the effects of three independent variables (power of microwave (X1: 50-350W), extraction time (X2: 20-90min), and extraction temperature (X3: 50-90°C)) on the extraction yield of APH. The effect of temperature and concentration on flow behavior of gum solution was studied. The viscosity of 2% APH solution was 0.55Pas at a shear rate of 10s(-1) at 20°C...
June 2014: International Journal of Biological Macromolecules
Cleante Scarduelli, Redenta Ghirardi, Ornella Tortelli, Rino Frizzelli, Fabia Mascaro, Claudio Pinzi
SESSION TITLE: DVT/PE PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Our purpose is to describe clinical presentation and diagnostic approach in 5 patients presenting with upper extremity deep vein thrombosis (UEDVT) central venous catheters (CVC)-related and pulmonary embolism after cardiac surgery METHODS: We report clinical caracteristics, diagnostic approach, management and evolution of 5 patients consecutively admitted to our Cardiopulmonary Rehabilitation Unit...
March 1, 2014: Chest
Olivier Gilbert, Alain Van Meerhaeghe, Myriam Remmelink, Benjamin Bondue, Matteo Cappello, Paul Devuyst, Philippe Pierard
SESSION TITLE: ILD Case Report Posters IISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: A 35-year-old African patient goes to pneumologist because of abnormal chest X-ray (during tuberculosis screening at work). CASE PRESENTATION: The CT scan showed extensive emphysema bubbles and sub pleural interstitial disease. The patient is non-smoking and serum 1- alpha antrypsine is normal. Raynaud's phenomenon is present for many years and exertional dyspnea (Sadoul 2)...
March 1, 2014: Chest
Satyawati Mohindra, Roopa Mehta, Amanjit Bal
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that is caused by hypersensitivity to Aspergillus fumigatus with resultant systemic immune activation, chronic asthma, recurrent pulmonary infiltrates, and bronchiectasis. First described by Hinson et al. (Thorax 7:317-333 [1]) in 1952, this disease occurs in 1-2% of patients with persistent asthma and in 2-15% of patients with cystic fibrosis (Greenberger, Front Biosci 8:s119-s127 [2]). Although the diagnostic criteria for ABPA have been laid down (and include bronchial asthma, immediate skin test reactivity to A...
January 2014: Indian Journal of Otolaryngology and Head and Neck Surgery
William J Calhoun
As noted in prior chapters, US national and international guidelines provide a consistent approach to initial management of asthma, based on easily observed physical and physiologic findings, and a detailed history. From those data, a rational initial therapeutic regimen can be prescribed. In many cases, such therapy results in near complete control of asthma symptoms, restoration of normal lung physiology, and elimination of exacerbations. In fact, such improvement is frequent enough that therapeutic responsiveness to asthma treatments was thought to be nearly universal...
2014: Advances in Experimental Medicine and Biology
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