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Masanori Yokoba, Tsuyoshi Ichikawa, Akira Takakura, Naohito Ishii, Yoshifumi Kurosaki, Yuya Yamada, Tomoaki Tsukushi, Noriyuki Masuda, Paul A Easton, Masato Katagiri
No abstract text is available yet for this article.
September 27, 2016: Pulmonary Pharmacology & Therapeutics
Mangayarkarasi Nivaskumar, Javier Santos-Moreno, Christian Malosse, Nathalie Nadeau, Julia Chamot-Rooke, Guy Tran Van Nhieu, Olivera Francetic
Type II secretion systems (T2SSs) promote secretion of folded proteins playing important roles in nutrient acquisition, adaptation and virulence of Gram-negative bacteria. Protein secretion is associated with the assembly of type 4 pilus (T4P)-like fibres called pseudopili. Initially membrane embedded, pseudopilin and T4 pilin subunits share conserved transmembrane segments containing an invariant Glu residue at the fifth position, E5. Mutations of E5 in major T4 pilins and in PulG, the major pseudopilin of the Klebsiella T2SS abolish fibre assembly and function...
September 2016: Molecular Microbiology
C A Guevara, E Parody, A F Aguirre
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
E Parody, C A Guevara, A F Aguirre
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Ludwig Kuntz, Jannis Pulm, Michael Wittland
BACKGROUND: Dynamic and complex transformations in the hospital market increase the relevance of good corporate governance. However, hospital performance and the characteristics of supervisory boards differ depending on ownership. The question therefore arises whether hospital owners can influence performance by addressing supervisory board characteristics. PURPOSE: The objective of this study is to explain differences in the financial performance of hospitals with regard to ownership by studying the size and composition of supervisory boards...
April 2016: Health Care Management Review
Mark J Haykowsky, Corey R Tomczak, Jessica M Scott, D Ian Paterson, Dalane W Kitzman
This mini-review summarizes the literature regarding the mechanisms of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction (HFREF and HFPEF, respectively). Evidence to date suggests that the reduced peak pulmonary oxygen uptake (pulm V̇o₂) in patients with HFREF compared with healthy controls is due to both central (reduced convective O₂ transport) and peripheral factors (impaired skeletal muscle blood flow, decreased diffusive O₂ transport coupled with abnormal skeletal morphology, and metabolism)...
September 15, 2015: Journal of Applied Physiology
Magdalena Kocur, Reiner Schneider, Ann-Kathrin Pulm, Jens Bauer, Sonja Kropp, Michael Gliem, Jens Ingwersen, Norbert Goebels, Judith Alferink, Timour Prozorovski, Orhan Aktas, Stefanie Scheu
INTRODUCTION: Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) leading to progressive neurological disability. Interferon β (IFNβ) represents a standard treatment for relapsing-remitting MS and exogenous administration of IFNβ exhibits protective effects in experimentally induced CNS autoimmunity. Also, genetic deletion of IFNβ in mice leads to an aggravation of disease symptoms in the MS model of experimental autoimmune encephalomyelitis (EAE)...
2015: Acta Neuropathologica Communications
Andreas Rolf, Johannes Rixe, Won K Kim, Johannes Börgel, Helge Möllmann, Holger M Nef, Christoph Liebetrau, Thorsten Kramm, Stefan Guth, Gabriele A Krombach, Eckhard Mayer, Christian W Hamm
BACKGROUND: The aim of the study was to characterize RV adaptation to varying loading conditions in patients with chronic thromboembolic hypertension (CTEPH) before and after pulmonary endarterectomy (PEA). Nearly 4% of patients with pulmonary embolism develop CTEPH. PEA offers a cure with excellent outcome. By use of cardiovascular magnetic resonance (CMR) combined with hemodynamic measurements pulmonary arterial elastance (Ea-pulm_i), end-systolic right ventricular elastance (Ees-RV_i) and ventriculo-arterial coupling (Ea-pulm_i/Ees-RV_i) can be studied before and after PEA...
2014: Journal of Cardiovascular Magnetic Resonance
Jonathan P Metters, Dimitrios K Kampouris, Craig E Banks
It has recently been demonstrated that 2-aminoacetophenone (2-AA) is a chemical indicator in exhaled air/breath of Pseudomonas aeruginosa infection associated with progressive life threatening decline of lung function in cystic fibrosis sufferers [Scott-Thomas et al., BMC Pulm. Med., 2010, 10, 56]. Currently the detection of 2-AA involves laboratory based instrumentation such as mass spectrometry and a hand-held point-of-care type breath device would be ideal in providing real-time results within seconds to accelerate patient care decision-making processes...
August 21, 2014: Analyst
Vahid Samavati, Farshid Skandari
The extraction of gum from Assyrian pulm fruit (APH) was performed by microwave-assisted extraction technique. A Box-Behnken design (BBD) was applied to evaluate the effects of three independent variables (power of microwave (X1: 50-350W), extraction time (X2: 20-90min), and extraction temperature (X3: 50-90°C)) on the extraction yield of APH. The effect of temperature and concentration on flow behavior of gum solution was studied. The viscosity of 2% APH solution was 0.55Pas at a shear rate of 10s(-1) at 20°C...
June 2014: International Journal of Biological Macromolecules
Cleante Scarduelli, Redenta Ghirardi, Ornella Tortelli, Rino Frizzelli, Fabia Mascaro, Claudio Pinzi
SESSION TITLE: DVT/PE PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Our purpose is to describe clinical presentation and diagnostic approach in 5 patients presenting with upper extremity deep vein thrombosis (UEDVT) central venous catheters (CVC)-related and pulmonary embolism after cardiac surgery METHODS: We report clinical caracteristics, diagnostic approach, management and evolution of 5 patients consecutively admitted to our Cardiopulmonary Rehabilitation Unit...
March 1, 2014: Chest
Olivier Gilbert, Alain Van Meerhaeghe, Myriam Remmelink, Benjamin Bondue, Matteo Cappello, Paul Devuyst, Philippe Pierard
SESSION TITLE: ILD Case Report Posters IISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: A 35-year-old African patient goes to pneumologist because of abnormal chest X-ray (during tuberculosis screening at work). CASE PRESENTATION: The CT scan showed extensive emphysema bubbles and sub pleural interstitial disease. The patient is non-smoking and serum 1- alpha antrypsine is normal. Raynaud's phenomenon is present for many years and exertional dyspnea (Sadoul 2)...
March 1, 2014: Chest
Satyawati Mohindra, Roopa Mehta, Amanjit Bal
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that is caused by hypersensitivity to Aspergillus fumigatus with resultant systemic immune activation, chronic asthma, recurrent pulmonary infiltrates, and bronchiectasis. First described by Hinson et al. (Thorax 7:317-333 [1]) in 1952, this disease occurs in 1-2% of patients with persistent asthma and in 2-15% of patients with cystic fibrosis (Greenberger, Front Biosci 8:s119-s127 [2]). Although the diagnostic criteria for ABPA have been laid down (and include bronchial asthma, immediate skin test reactivity to A...
January 2014: Indian Journal of Otolaryngology and Head and Neck Surgery
William J Calhoun
As noted in prior chapters, US national and international guidelines provide a consistent approach to initial management of asthma, based on easily observed physical and physiologic findings, and a detailed history. From those data, a rational initial therapeutic regimen can be prescribed. In many cases, such therapy results in near complete control of asthma symptoms, restoration of normal lung physiology, and elimination of exacerbations. In fact, such improvement is frequent enough that therapeutic responsiveness to asthma treatments was thought to be nearly universal...
2014: Advances in Experimental Medicine and Biology
L Kuntz, J Pulm, M Wittland
AIM OF THE STUDY: When thinking about corporate governance frequently the supervisory board comes to mind. The aim of this study is to investigate the relationship between the participation of single professions in the supervisory board and hospital financial performance. METHODS: Based on governance codes, relevant professions that should be part of the supervisory board are identified. With the help of a multiple regression, the relationship between the fractions of these professions in the supervisory board and the return on assets in the year 2009 is examined...
June 2014: Das Gesundheitswesen
William T Harris, David R Kelly, Yong Zhou, Dezhi Wang, Mark MacEwen, Mark Macewen, James S Hagood, J P Clancy, Namasivayam Ambalavanan, Eric J Sorscher
RATIONALE: TGF-β, a mediator of pulmonary fibrosis, is a genetic modifier of CF respiratory deterioration. The mechanistic relationship between TGF-β signaling and CF lung disease has not been determined. OBJECTIVE: To investigate myofibroblast differentiation in CF lung tissue as a novel pathway by which TGF-β signaling may contribute to pulmonary decline, airway remodeling and tissue fibrosis. METHODS: Lung samples from CF and non-CF subjects were analyzed morphometrically for total TGF-β1, TGF-β signaling (Smad2 phosphorylation), myofibroblast differentiation (α-smooth muscle actin), and collagen deposition (Masson trichrome stain)...
2013: PloS One
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