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https://www.readbyqxmd.com/read/29163657/a-sonographic-doppler-study-of-the-hepatic-vein-portal-vein-and-hepatic-artery-in-liver-cirrhosis-correlation-of-hepatic-hemodynamics-with-clinical-child-pugh-score-in-singapore
#1
Azizah M Afif, Jason Pik-Eu Chang, Yan Y Wang, Simin D Lau, Fuzhen Deng, Shy Y Goh, Mar K Pwint, Chin C Ooi, Nanda Venkatanarasimha, Richard Hg Lo
Objective: Liver cirrhosis has been a rising complication of chronic liver disease in Singapore. Ultrasound has been widely accepted as a non-invasive imaging modality for the evaluation of hepatic haemodynamics. This study aims to correlate the Doppler ultrasound values with the progression of liver cirrhosis to allow further understanding and possible prediction of clinical events for timely intervention. Methods: Study sample of 56 eligible patients with liver cirrhosis was divided according to their Child-Pugh clinical score into Child's A (n = 29 patients), B (n = 19 patients) and C (n = 8 patients)...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29162847/clinical-and-immunopathological-findings-during-long-term-follow-up-in-leishmania-infantum-experimentally-infected-dogs
#2
Melissa Moura Costa Abbehusen, Valter Dos Anjos Almeida, Manuela da S Solcà, Laís da Silva Pereira, Dirceu Joaquim Costa, Leonardo Gil-Santana, Patricia Torres Bozza, Deborah Bittencourt Moté Fraga, Patrícia Sampaio Tavares Veras, Washington Luis Conrado Dos-Santos, Bruno Bezerril Andrade, Claudia Ida Brodskyn
Canine Visceral Leishmaniasis (CVL) is caused by Leishmania infantum, which in the New World is transmitted by Lutzomyia longipalpis. While prospective clinical and immunological assessments of dogs experimentally challenged with L. infantum have been previously reported over a relatively short follow-up period, the long-term characterization of infected animals has not been performed to date. We evaluated dogs in a subclinical state for six years following experimental infection with L. infantum and Lu. longipalpis saliva, via an intradermal route, to characterize clinical, parasitological and immunological parameters arising from L...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29161297/prognostic-performance-of-mr-pro-adrenomedullin-in-patients-with-community-acquired-pneumonia-in-the-emergency-department-compared-to-clinical-severity-scores-psi-and-curb
#3
Jacopo Maria Legramante, Maria Mastropasqua, Beniamino Susi, Ottavia Porzio, Marta Mazza, Grazia Miranda Agrippino, Cartesio D Agostini, Antonella Brandi, Germano Giovagnoli, Vito Nicola Di Lecce, Sergio Bernardini, Marilena Minieri
AIM: (i) evaluate the performance of MR-pro-ADM in reflecting the outcome and risk for CAP patients in the emergency department, and (ii) compare the prognostic performance of MR-pro-ADM with that of clinical scores PSI and CURB65. METHODS: Observational prospective, single-center study in patients with suspected community acquired pneumonia (CAP). Eighty one patients underwent full clinical and laboratory assessment as by protocol, and were followed up a 28 days...
2017: PloS One
https://www.readbyqxmd.com/read/29158244/post-traumatic-knee-mri-findings-and-associations-with-patient-trauma-and-clinical-characteristics-a-subgroup-analysis-in-primary-care-in-the-netherlands
#4
Kim van Oudenaarde, Nynke M Swart, Johan L Bloem, Sita Ma Bierma-Zeinstra, Paul R Algra, Bart Koes, Jan Verhaar, Rob Ghh Nelissen, Patrick Je Bindels, Pim Aj Luijsterburg, Monique Reijnierse
BACKGROUND: The added value of magnetic resonance imaging (MRI) in primary care is still being debated. A high diagnostic yield can be expected in young and active patients with post-traumatic knee complaints. AIM: To determine the frequency of MRI abnormalities in young and active patients (aged 18-45 years) and the associations with patient, trauma, and clinical characteristics. DESIGN AND SETTING: A subgroup analysis of 174 patients, aged 18-45 years with knee trauma of <6 months, allocated to MRI in a randomised controlled trial on the yield of MRI in primary care...
November 20, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29157898/radiologic-and-clinical-evaluation-of-a-bioabsorbable-collagen-implant-to-treat-partial-thickness-tears-a-prospective-multicenter-study
#5
Theodore F Schlegel, Jeffrey S Abrams, Brandon D Bushnell, J Logan Brock, Charles P Ho
BACKGROUND: Treatment of partial-thickness cuff tears remains controversial. Although conservative therapy may treat symptoms, these defects do not spontaneously heal and conversion to a full-thickness lesion with subsequent repair may alter the tendon footprint. The ability to induce new tissue formation and limit tear progression in intermediate- and high-grade partial-thickness tears without surgical repair may represent a significant advancement in the treatment paradigm for these lesions...
November 17, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29157109/comparison-of-patellar-tracking-according-to-different-angles-of-external-rotation-of-femoral-component-in-varus-knee-of-asians
#6
Jai Hyung Park, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Chang-Rack Lee, Jong-Min Kim, Yongun Cho
PURPOSE: Racial difference in the femoral geometry may exist. Asian femurs may be more externally rotated. If anatomical differences in distal femur had existed between Caucasians and Asians, the group with 5° external rotation of the femoral component should have shown better results than the group with 3° external rotation of the femoral component have. METHODS: 598 patients underwent total knee arthroplasty in our institution, among whom 83 patients (115 knees) who had postoperative computed tomography (CT) were studied retrospectively...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29155752/sagittal-plane-kinematic-gait-analysis-in-c57bl-6-mice-subjected-to-mog35-55-induced-experimental-autoimmune-encephalomyelitis
#7
Maximillian Dj Fiander, Matthew Aj Chedrawe, Anna-Claire Lamport, Turgay Akay, George S Robertson
Kinematic gait analysis in the sagittal plane has frequently been used to characterize motor deficits in multiple sclerosis (MS). We describe the application of these techniques to identify gait deficits in a mouse model of MS, known as experimental autoimmune encephalomyelitis (EAE). Paralysis and motor deficits in mice subjected to EAE are typically assessed using a clinical scoring scale. However, this scale yields only ordinal data that provides little information about the precise nature of the motor deficits...
November 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29153963/shear-wave-elastography-swe-for-monitoring-of-treatment-of-tendinopathies-a-double-blinded-longitudinal-clinical-study
#8
Timm Dirrichs, Valentin Quack, Matthias Gatz, Markus Tingart, Björn Rath, Marcel Betsch, Christiane K Kuhl, Simone Schrading
RATIONALE AND OBJECTIVES: We aimed to investigate the diagnostic accuracy with which shear wave elastography (SWE) can be used to monitor response to treatment of tendinopathies, and to compare it to conventional ultrasound (US)-imaging methods (B-mode US (B-US) and power Doppler US (PD-US)). MATERIALS AND METHODS: A prospective Institutional Review Board-approved longitudinal study on 35 patients with 47 symptomatic tendons (17 Achilles-, 15 patellar-, and 15 humeral-epicondylar) who underwent standardized multimodal US and standardized clinical assessment before and after 6 months of treatment (tailored stretching exercise, sport break, and local Polidocanol) was carried out...
November 16, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29153632/a-2-to-16-year-clinical-follow-up-of-revision-total-hip-arthroplasty-using-a-new-acetabular-implant-combined-with-impacted-bone-allografts-and-a-cemented-cup
#9
Hampus Stigbrand, Oscar Gustafsson, Gösta Ullmark
BACKGROUND: Treatment of acetabular bone loss with impaction bone grafting (IBG) at revision total hip arthroplasty is highly dependent on mechanical stability and graft compression for clinical success. Here, we describe a new technique to further compress and stabilize the acetabular graft bed with a thin, perforated titanium shell. METHODS: We retrospectively analyzed 170 cases of acetabular revision arthroplasty 7 years (standard deviation 2.8) after IBG combined with a graft-compressing titanium shell implant...
October 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29150086/the-ex-vivo-toll-like-receptor-7-tolerance-induction-in-donor-lymphocytes-prevents-murine-acute-graft-versus-host-disease
#10
Nikolaos Zogas, Garyfalia Karponi, Fotios Iordanidis, Stylianos Malasidis, Vasilios Paraskevas, Anastasia Papadopoulou, Zaharias George Scouras, Achilles Anagnostopoulos, Evangelia Yannaki
BACKGROUND AIMS: Acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation, mediated by alloreactive donor T cells. Toll-like receptors (TLRs), a family of conserved pattern-recognition receptors (PRRs), represent key players in donors' T-cell activation during aGVHD; however, a regulatory, tolerogenic role for certain TLRs has been recognized in a different context. We investigated whether the ex vivo-induced TLR-2,-4,-7 tolerance in donor cells could prevent alloreactivity in a mismatched transplantation model...
November 14, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29147741/achilles-tendon-elastic-properties-remain-decreased-in-long-term-after-rupture
#11
B Frankewycz, A Penz, J Weber, N P da Silva, F Freimoser, R Bell, M Nerlich, E M Jung, D Docheva, C G Pfeifer
PURPOSE: Rupture of the Achilles tendon results in inferior scar tissue formation. Elastography allows a feasible in vivo investigation of biomechanical properties of the Achilles tendon. The purpose of this study is to investigate the biomechanical properties of healed Achilles tendons in the long term. MATERIALS AND METHODS: Patients who suffered from Achilles tendon rupture were recruited for an elastographic evaluation. Unilateral Achilles tendon ruptures were included and scanned in the mid-substance and calcaneal insertion at least 2 years after rupture using shear wave elastography...
November 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29146590/camkii%C3%AE-mediates-the-effect-of-il-17-to-promote-ongoing-spontaneous-and-evoked-pain-in-multiple-sclerosis
#12
Xiaoyu Hu, Fang Huang, Zaijie Jim Wang
Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca(2+)/calmodulin dependent kinase type IIα (CaMKIIα) in driving chronic pain in MS using a mouse experimental autoimmune encephalomyelitis (EAE) model. We found that spinal CaMKIIα activity was enhanced in EAE correlating with the development of ongoing spontaneous pain and evoked hypersensitivity to mechanical and thermal stimuli...
November 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29146221/takedown-of-ankle-arthrodesis-with-insufficient-fibula-surgical-technique-and-intermediate-term-follow-up
#13
John M Schuberth, Jeffrey C Christensen, Chad Seidenstricker
Conversion of ankle arthrodesis to total ankle arthroplasty has recently gained popularity. However, technical challenges are present when treating patients without a sufficient fibular buttress. We describe a technique for restoration of an adequate fibular buttress using an iliac crest bone graft or malleolar relocation. The results of 10 patients with an average follow-up period of 56 (range 24 to 123) months are presented. Of the 10 patients, 3 underwent tricortical iliac bone augmentation of the fibula, 4 underwent repositioning of the remnant fibula, and in 3, the in situ fibula was used...
November 14, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29142955/improving-the-prediction-of-cardiac-surgery-associated-acute-kidney-injury
#14
Jordan Crosina, Jordyn Lerner, Julie Ho, Navdeep Tangri, Paul Komenda, Brett Hiebert, Nora Choi, Rakesh C Arora, Claudio Rigatto
Introduction: Acute kidney injury (AKI) is a potentially fatal complication of cardiac surgery. The inability to predict cardiac surgery-associated AKI is a major barrier to prevention and early treatment. Current clinical risk models for the prediction of cardiac surgery-associated AKI are insufficient, particularly in patients with preexisting kidney dysfunction. Methods: To identify intraoperative variables that might improve the performance of a validated clinical risk score (Cleveland Clinic Score, CCS) for the prediction of cardiac surgery-associated AKI, we conducted a prospective cohort study in 289 consecutive elective cardiac surgery patients at a tertiary care center...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29138829/resveratrol-ameliorates-inflammatory-damage-and-protects-against-osteoarthritis-in-a-rat-model-of-osteoarthritis
#15
Yulong Wei, Jie Jia, Xin Jin, Wei Tong, Hongtao Tian
Resveratrol is a non‑flavonoid polyphenol compound with a stilbene structure. As a type of phytoalexin produced under stress in plants, it improves the plant's resistance against pathogens and environment deterioration, and performs important functions beneficial to human health, such as anti‑cancer, anti‑oxidation, regulating blood lipid levels and prolonging life span. The effects of resveratrol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136209/use-of-18f-fluorodeoxyglucose-positron-emission-tomography-in-the-diagnosis-of-polymyalgia-rheumatica-a-prospective-study-of-99-patients
#16
Liesbet Henckaerts, Olivier Gheysens, Steven Vanderschueren, Karolien Goffin, Daniel Blockmans
Objective: Previous studies have shown that the majority of patients with PMR have increased 18F-fluorodeoxyglucose (FDG) uptake around the shoulders, hips and processes of the cervical and lumbar spine on PET. The specificity of these findings for PMR is, however, not known. Methods: We prospectively included 99 consecutive patients with a possible clinical diagnosis of PMR. All patients underwent 18F-FDG-PET scanning before treatment with glucocorticoids was started...
October 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29131690/investigating-ioflupane-i-123-injection-and-single-photon-emission-tomography-as-an-imaging-biomarker-for-long-term-sequelae-following-mild-traumatic-brain-injury
#17
Nicole Reams, Julie Anderson, Reid Perlman, Wei Li, Shaun Walters, Samuel Tideman, Chi Wang, Kelly Simon, Roberta Frigerio, Demetrius M Maraganore
OBJECTIVE: To determine whether there were differences in clinical outcomes for ioflupane I(123) injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI). METHODS: We performed a case-control study among patients presenting to the Emergency Room (ER) during 2006-2013 with mTBI (cases, n = 34) or without mTBI (controls, n = 33). We performed clinical and imaging measurements in cases and controls at least 1-year post-presentation to the ER (average three years four months)...
November 13, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29128878/microfracture-is-more-cost-effective-than-autologous-chondrocyte-implantation-a-review-of-level-1-and-level-2-studies-with-5%C3%A2-year-follow-up
#18
Tommy Frøseth Aae, Per-Henrik Randsborg, Hilde Lurås, Asbjørn Årøen, Øystein Bjerkestrand Lian
PURPOSE: Focal cartilage defects in the knee may have devastating effect on the knee joint, where two of the main surgical treatment options are microfracture and autologous chondrocyte implantation. Comparative studies have failed to establish which method yields the best clinical results. A cost-effectiveness analysis of microfracture and autologous chondrocyte implantation would contribute to the clinical decision process. METHODS: A PubMed search identifying level I and level II studies with 5 year follow-up was performed...
November 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29124774/early-drug-and-anti-infliximab-antibody-levels-for-prediction-of-primary-nonresponse-to-infliximab-therapy
#19
H Bar-Yoseph, N Levhar, L Selinger, U Manor, M Yavzori, O Picard, E Fudim, U Kopylov, R Eliakim, S Ben-Horin, Y Chowers, B Ungar
BACKGROUND: Primary nonresponse, defined as lack of clinical benefit during the induction phase, occurs in up to 30% of IBD patients treated with infliximab. The mechanisms underlying primary nonresponse have not yet been clearly defined. AIM: To evaluate the association of early (week 2 and week 6) induction infliximab and anti-infliximab antibody levels with primary nonresponse. METHODS: A retrospective observational case-control study of inflammatory bowel disease patients treated with infliximab and followed at Sheba Medical Center between 2009 and 2016 was performed...
November 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29123605/evaluation-of-modified-alvarado-scoring-system-and-ripasa-scoring-system-as-diagnostic-tools-of-acute-appendicitis
#20
Abdullah Shuaib, Ali Shuaib, Zainab Fakhra, Bader Marafi, Khalid Alsharaf, Abdullah Behbehani
BACKGROUND: Acute appendicitis is the most common surgical condition presented in emergency departments worldwide. Clinical scoring systems, such as the Alvarado and modified Alvarado scoring systems, were developed with the goal of reducing the negative appendectomy rate to 5%-10%. The Raja Isteri Pengiran Anak Saleha Appendicitis (RIPASA) scoring system was established in 2008 specifically for Asian populations. The aim of this study was to compare the modified Alvarado with the RIPASA scoring system in Kuwait population...
2017: World Journal of Emergency Medicine
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