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https://www.readbyqxmd.com/read/28444541/reverse-shoulder-arthroplasty-for-massive-irreparable-rotator-cuff-tears-and-cuff-tear-arthropathy-a-systematic-review
#1
REVIEW
S Petrillo, U G Longo, R Papalia, V Denaro
PURPOSE: To report the outcomes and complications of reverse shoulder arthroplasty (RSA) in massive irreparable rotator cuff tears (MIRCT) and cuff tear arthropathy (CTA). METHODS: A systematic review of the literature contained in Medline, Cochrane, EMBASE, Google Scholar and Ovid databases was conducted on May 1, 2016, according to PRISMA guidelines. The key words "reverse total shoulder arthroplasty" or "reverse total shoulder prostheses" with "rotator cuff tears"; "failed rotator cuff surgery"; "massive rotator cuff tears"; "irreparable rotator cuff tears"; "cuff tear arthropathy"; "outcomes"; "complications" were matched...
April 25, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28443501/testicular-dysfunction-is-a-common-feature-in-men-with-type2-diabetes-mellitus-in-a-nigerian-tertiary-hospital
#2
Onung Samuel Inih, Young Ekenechukwu Esther, Fasanmade Olufemi Adetola, Anyanwu Anthony Chinedu, Nwatu Chidinma Brenda, Ohwovoriole Augustine Efedaye
BACKGROUND: Hypogonadism in male patients with diabetes mellitus is associated with older age, obesity and poor glycaemic control. The patterns of sperm count, testicular volume, sperm motility and morphology have also been reported to be abnormal in these patients, though reports are conflicting. The objectives of this study were to assess gonadal function and sperm parameters in Nigerian males with diabetes mellitus. METHODS: A study sample of 150 males consisting of 108 patients and 56 age-matched controls were recruited...
April 25, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28439705/cementless-oxford-medial-unicompartimental-knee-replacement-an-independent-series-with-a-5-year-follow-up
#3
Benjamin Panzram, Ines Bertlich, Tobias Reiner, Tilman Walker, Sébastien Hagmann, Tobias Gotterbarm
PURPOSE: Cemented unicompartmental knee replacement (UKR) has proven excellent long-term survival rates and functional scores in Price et al. (Clin Orthop Relat Res 435:171-180, 2005), Price and Svard (Clin Orthop Relat Res 469(1):174-179, 2011) and Murray et al. (Bone Joint Surg Br 80(6):983-989, 1998). The main causes for revision, aseptic loosening and pain of unknown origin might be addressed by cementless UKR in Liddle et al. (Bone Joint J 95-B(2):181-187, 2013), Pandit et al. (J Bone Joint Surg Am 95(15):1365-1372, 2013), National Joint Registry for England, Wales and Northern Ireland: 10th Annual Report 2013 ( http://www...
April 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28439636/kinematic-alignment-is-a-possible-alternative-to-mechanical-alignment-in-total-knee-arthroplasty
#4
Yong Seuk Lee, Stephen M Howell, Ye-Yeon Won, O-Sung Lee, Seung Hoon Lee, Hamed Vahedi, Seow Hui Teo
PURPOSE: A systematic review was conducted to answer the following questions: (1) Does kinematically aligned (KA) total knee arthroplasty (TKA) achieve clinical outcomes comparable to those of mechanically aligned (MA) TKA? (2) How do the limb, knee, and component alignments differ between KA and MA TKA? (3) How is joint line orientation angle (JLOA) changed from the native knee in KA TKA compared to that in MA TKA? METHODS: Nine full-text articles in English that reported the clinical and radiological outcomes of KA TKA were included...
April 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28436602/accuracy-of-circulating-histones-in-predicting-persistent-organ-failure-and-mortality-in-patients-with-acute-pancreatitis
#5
T Liu, W Huang, P Szatmary, S T Abrams, Y Alhamdi, Z Lin, W Greenhalf, G Wang, R Sutton, C H Toh
BACKGROUND: Early prediction of acute pancreatitis severity remains a challenge. Circulating levels of histones are raised early in mouse models and correlate with disease severity. It was hypothesized that circulating histones predict persistent organ failure in patients with acute pancreatitis. METHODS: Consecutive patients with acute pancreatitis fulfilling inclusion criteria admitted to Royal Liverpool University Hospital were enrolled prospectively between June 2010 and March 2014...
April 24, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28435306/pediatric-acute-kidney-injury-prevalence-impact-and-management-challenges
#6
REVIEW
Eileen Ciccia, Prasad Devarajan
The incidence of pediatric acute kidney injury (AKI) is increasing globally, as are the associated morbidities and mortality. A recent standardization of the definition of AKI has allowed for a more accurate assessment of the epidemiology of pediatric AKI. Recent advances in leveraging electronic medical health record systems have allowed for real-time risk stratification and prevention of pediatric AKI in the hospital setting. Newly developed and validated clinical scores have improved our ability to predict AKI and provide a rational context for biomarker utilization in hospitalized children...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28431813/evaluation-of-immune-responses-of-stabilised-sat2-antigens-of-foot-and-mouth-disease-in-cattle
#7
Katherine A Scott, N M Rathogwa, A V Capozzo, Francois F Maree
Foot-and-mouth disease (FMD) vaccines with improved stability and less reliant on a cold-chain are needed to improve the longevity of immune responses elicited in animals. This is especially so for serotypes O and SAT2 which are unstable in mildly acidic pH conditions or at elevated temperatures leading to dissociation of the capsid (146S particle) and loss of immunogenicity. Previously, stabilised SAT2 viruses were generated by reverse genetic approaches and assessed in vitro and in vivo with a guinea pig trial...
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28431183/efficacy-of-tiamulin-alone-or-in-combination-with-chlortetracycline-against-experimental-mycoplasma-gallisepticum-infection-in-chickens
#8
A Garmyn, M Vereecken, K Degussem, W Depondt, F Haesebrouck, A Martel
Mycoplasma gallisepticum (M. gallisepticum) remains one of the most important diseases in poultry production. Controlling the impact of the disease is done by eradication of positive breeder flocks or by vaccination and medication. A widely used molecule in medication programs is tiamulin, a pleuromutilin antibiotic. Since recent data on the in vivo efficacy of this molecule are scarce, 2 challenge studies were conducted using a recently isolated M. gallisepticum strain belonging to the wildtype population with regard to its tiamulin and tetracycline minimum inhibitory concentration (MIC)...
April 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28429747/imaging-genetics-approach-to-parkinson-s-disease-and-its-correlation-with-clinical-score
#9
Mansu Kim, Jonghoon Kim, Seung-Hak Lee, Hyunjin Park
Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with both underlying genetic factors and neuroimaging findings. Existing neuroimaging studies related to the genome in PD have mostly focused on certain candidate genes. The aim of our study was to construct a linear regression model using both genetic and neuroimaging features to better predict clinical scores compared to conventional approaches. We obtained neuroimaging and DNA genotyping data from a research database. Connectivity analysis was applied to identify neuroimaging features that could differentiate between healthy control (HC) and PD groups...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#10
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28418575/effects-of-previous-osteotomy-on-outcome-of-hip-resurfacing-arthroplasty
#11
Harlan Cabot Amstutz, Michel Jean Le Duff
The effect of previous conservative surgeries on the outcome of metal-on-metal hip resurfacing arthroplasty (HRA) has not been studied. This study compared postoperative clinical scores and survivorship results of hips with and without previous osteotomies in a population of patients who underwent HRA. A total of 1101 patients (1375 hips) with a mean age of 51.3 years at the time of surgery underwent HRA at a single center. Sixty-nine patients had undergone prior surgery on the operated hip including 14 osteotomies (1 pelvic, 6 femoral, and 7 combined pelvic and femoral osteotomies)...
April 18, 2017: Orthopedics
https://www.readbyqxmd.com/read/28417201/quantification-of-dynamic-posterior-translation-in-modified-bilateral-alexander-views-and-correlation-with-clinical-and-radiological-parameters-in-patients-with-acute-acromioclavicular-joint-instability
#12
Marvin Minkus, Carmen Hann, Markus Scheibel, Natascha Kraus
INTRODUCTION: Classification of AC-joint instability is based on radiologic evaluation of anteroposterior (a.p.) stress views of both shoulders, neglecting the horizontal component of instability. Recent studies have proposed an association of dynamic posterior translation (DPT) and inferior clinical results. The purpose of this study was to quantify DPT in modified Alexander views and correlate it with other radiological and clinical data. MATERIALS AND METHODS: Thirty-two patients (4 f, 28 m, mean age 34...
April 17, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28416405/development-validation-and-assessment-of-an-ischemic-stroke-or-transient-ischemic-attack-specific-prediction-tool-for-obstructive-sleep-apnea
#13
Jason J Sico, H Klar Yaggi, Susan Ofner, John Concato, Charles Austin, Jared Ferguson, Li Qin, Lauren Tobias, Stanley Taylor, Carlos A Vaz Fragoso, Vincent McLain, Linda S Williams, Dawn M Bravata
BACKGROUND: Screening instruments for obstructive sleep apnea (OSA), as used routinely to guide clinicians regarding patient referral for polysomnography (PSG), rely heavily on symptomatology. We sought to develop and validate a cerebrovascular disease-specific OSA prediction model less reliant on symptomatology, and to compare its performance with commonly used screening instruments within a population with ischemic stroke or transient ischemic attack (TIA). METHODS: Using data on demographic factors, anthropometric measurements, medical history, stroke severity, sleep questionnaires, and PSG from 2 independently derived, multisite, randomized trials that enrolled patients with stroke or TIA, we developed and validated a model to predict the presence of OSA (i...
April 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28413661/non-alcoholic-fatty-liver-disease-fibrosis-score-predicts-hematological-toxicity-of-chemotherapy-including-irinotecan-for-colorectal-cancer
#14
Masashi Yahagi, Masashi Tsuruta, Hirotoshi Hasegawa, Koji Okabayashi, Yuko Kitagawa
Liver dysfunction that may affect drug metabolism is a major concern in patients treated with chemotherapy. Thus, assessment of the degree of liver dysfunction is crucial for predicting the adverse events of chemotherapy. The non-alcoholic fatty liver disease fibrosis score (NFS) is a non-invasive clinical scoring system constructed from routine clinical and laboratory variables. The aim of this study was to evaluate whether NFS was useful for predicting the adverse events of chemotherapy including irinotecan (CPT-11) for colorectal cancer...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28412875/amino-acid-and-acylcarnitine-profiles-in-perinatal-asphyxia-a-case-control-study
#15
Ola Galal El-Farghali, Mohamed Sami El-Chimi, Heba Salah El-Abd, Eman El-Desouky
OBJECTIVE: To estimate cord blood amino acid and acylcarnitine levels in term newborns exposed to perinatal asphyxia. MATERIALS AND METHODS: We studied 45 asphyxiated term newborns (cases) and 20 gestational age-matched healthy newborns (control). Sixteen cases developed HIE according to clinical scoring and amplitude-integrated electroencephalography. Asphyxiated cases were accordingly subdivided into: HIE group (n = 16) and Asphyxia group (n = 29). Amino acid and acylcarnitine levels were measured in cord blood dried spot samples from all newborns using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28412677/differential-analysis-of-clinical-efficacy-on-patients-with-serious-infection-in-icu-by-different-meropenem-regimens
#16
Wei-Min Wang, Xu-Sheng An, Xiang-Cheng Zhang, Liang-Liang Hui, Shi-Guang Guo, Bei-Bei Chen, Kui Zang, Fu-Tai Shang, Long-Chuan Wu
To investigate the difference in clinical efficacy and safety of different meropenem regimens on patients with serious infection in ICU. Then, 228 patients with serious infection in ICU were divided by random into control group (intermittent administration in 1000mg/30min single dose) and research group (continuous administration in 200mg/10min +800mg/180min), respectively. The blood concentration of meropenem were recorded in two groups at different time points, and difference in treatment effectiveness, iconographic effectiveness, bacterial eradication rate, 28-day survival rate and many other clinical scoring indices (SOFA, APACHEII, CPIS, and SIRS) were compared between two groups...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28411264/grecos-project-genotyping-recurrence-risk-of-stroke-the-use-of-genetics-to-predict-the-vascular-recurrence-after-stroke
#17
Israel Fernández-Cadenas, Maite Mendióroz, Dolors Giralt, Cristina Nafria, Elena Garcia, Caty Carrera, Cristina Gallego-Fabrega, Sophie Domingues-Montanari, Pilar Delgado, Marc Ribó, Mar Castellanos, Sergi Martínez, Marimar Freijo, Jordi Jiménez-Conde, Marta Rubiera, José Alvarez-Sabín, Carlos A Molina, Maria Angels Font, Marta Grau Olivares, Ernest Palomeras, Natalia Perez de la Ossa, Maite Martinez-Zabaleta, Jaime Masjuan, Francisco Moniche, David Canovas, Carlos Piñana, Francisco Purroy, Dolores Cocho, Inma Navas, Carlos Tejero, Nuria Aymerich, Natalia Cullell, Elena Muiño, Joaquín Serena, Francisco Rubio, Antoni Davalos, Jaume Roquer, Juan Francisco Arenillas, Joan Martí-Fábregas, Keith Keene, Wei-Min Chen, Bradford Worrall, Michele Sale, Adrià Arboix, Jerzy Krupinski, Joan Montaner
BACKGROUND AND PURPOSE: Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS: We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients...
April 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28408779/effect-of-the-probiotic-lactobacillus-murinus-lbp2-on-clinical-parameters-of-dogs-with-distemper-associated-diarrhea
#18
Luis Delucchi, Martín Fraga, Pablo Zunino
The objective of this study was to assess the effect of the probiotic Lactobacillus murinus native strain (LbP2) on general clinical parameters of dogs with distemper-associated diarrhea. Two groups of dogs over 60 d of age with distemper and diarrhea were used in the study, which was done at the Animal Hospital of the Veterinary Faculty of the University of Uruguay, Montevideo, Uruguay. The dogs were treated orally each day for 5 d with the probiotic or with a placebo (vehicle without bacteria). Clinical parameters were assessed and scored according to a system specially designed for this study...
April 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28408402/poly-gp-in-cerebrospinal-fluid-links-c9orf72-associated-dipeptide-repeat-expression-to-the-asymptomatic-phase-of-als-ftd
#19
Carina Lehmer, Patrick Oeckl, Jochen H Weishaupt, Alexander E Volk, Janine Diehl-Schmid, Matthias L Schroeter, Martin Lauer, Johannes Kornhuber, Johannes Levin, Klaus Fassbender, Bernhard Landwehrmeyer, Martin H Schludi, Thomas Arzberger, Elisabeth Kremmer, Andrew Flatley, Regina Feederle, Petra Steinacker, Patrick Weydt, Albert C Ludolph, Dieter Edbauer, Markus Otto
The C9orf72 GGGGCC repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). Non-conventional repeat translation results in five dipeptide repeat proteins (DPRs), but their clinical utility, overall significance, and temporal course in the pathogenesis of c9ALS/FTD are unclear, although animal models support a gain-of-function mechanism. Here, we established a poly-GP immunoassay from cerebrospinal fluid (CSF) to identify and characterize C9orf72 patients. Significant poly-GP levels were already detectable in asymptomatic C9orf72 mutation carriers compared to healthy controls and patients with other neurodegenerative diseases...
April 13, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28407727/randomized-clinical-trial-of-real-time-fmri-amygdala-neurofeedback-for-major-depressive-disorder-effects-on-symptoms-and-autobiographical-memory-recall
#20
Kymberly D Young, Greg J Siegle, Vadim Zotev, Raquel Phillips, Masaya Misaki, Han Yuan, Wayne C Drevets, Jerzy Bodurka
OBJECTIVE: Patients with depression show blunted amygdala hemodynamic activity to positive stimuli, including autobiographical memories. The authors examined the therapeutic efficacy of real-time functional MRI neurofeedback (rtfMRI-nf) training aimed at increasing the amygdala's hemodynamic response to positive memories in patients with depression. METHOD: In a double-blind, placebo-controlled, randomized clinical trial, unmedicated adults with depression (N=36) were randomly assigned to receive two sessions of rtfMRI-nf either from the amygdala (N=19) or from a parietal control region not involved in emotional processing (N=17)...
April 14, 2017: American Journal of Psychiatry
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