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https://www.readbyqxmd.com/read/28526917/do-we-know-the-outcome-predictors-for-cauda-equine-syndrome-ces-a-retrospective-single-center-analysis-of-60-patients-with-ces-with-a-suggestion-for-a-new-score-to-measure-severity-of-symptoms
#1
Alexander König, Lisa Amelung, Marco Danne, Ullrich Meier, Johannes Lemcke
OBJECTIVE: Despite the awareness and familiarity of almost every medical professional with the cauda equine compression syndrome (CES), risk factors for a poor prognosis of the disease remain elusive. Even the relationship between subsequent outcome and the time elapsed from the time of appearance of symptoms to surgery taking place remain obscure. The aim of our study, therefore, was to analyze a relatively large population of our own patients studied consecutively, to identify outcome predictors for CES and to propose a clinical score for CES symptoms (Berlin CES score)...
May 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28526675/iterative-user-interface-design-for-automated-sequential-organ-failure-assessment-score-calculator-in-sepsis-detection
#2
Christopher Ansel Aakre, Jaben E Kitson, Man Li, Vitaly Herasevich
BACKGROUND: The new sepsis definition has increased the need for frequent sequential organ failure assessment (SOFA) score recalculation and the clerical burden of information retrieval makes this score ideal for automated calculation. OBJECTIVE: The aim of this study was to (1) estimate the clerical workload of manual SOFA score calculation through a time-motion analysis and (2) describe a user-centered design process for an electronic medical record (EMR) integrated, automated SOFA score calculator with subsequent usability evaluation study...
May 18, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28522144/viscoelastic-tissue-plasminogen-activator-challenge-predicts-massive-transfusion-in-15-minutes
#3
Hunter B Moore, Ernest E Moore, Michael P Chapman, Benjamin R Huebner, Peter M Einersen, Solimon Oushy, Christopher C Silliman, Anirban Banerjee, Angela Sauaia
BACKGROUND: Coagulopathy is associated with massive transfusion in trauma, yet most clinical scores to predict this end point do not incorporate coagulation assays. Previous work has identified that shock increases circulating tissue plasminogen activator (tPA). When tPA levels saturate endogenous inhibitors, systemic hyperfibrinolysis can occur. Therefore, the addition of tPA to a patient's blood sample could stratify a patients underlying degree of shock and early coagulation changes to predict progression to massive transfusion...
April 17, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28515796/genetic-heterogeneity-of-patients-with-suspected-silver-russell-syndrome-genome-wide-copy-number-analysis-in-82-patients-without-imprinting-defects
#4
Takanobu Inoue, Akie Nakamura, Tomoko Fuke, Kazuki Yamazawa, Shinichiro Sano, Keiko Matsubara, Seiji Mizuno, Yoshika Matsukura, Chie Harashima, Tatsuji Hasegawa, Hisakazu Nakajima, Kumi Tsumura, Zenro Kizaki, Akira Oka, Tsutomu Ogata, Maki Fukami, Masayo Kagami
BACKGROUND: Silver-Russell syndrome (SRS) is a rare congenital disorder characterized by pre- and postnatal growth failure and dysmorphic features. Recently, pathogenic copy number variations (PCNVs) and imprinting defects other than hypomethylation of the H19-differentially methylated region (DMR) and maternal uniparental disomy chromosome 7 have been reported in patients with the SRS phenotype. This study aimed to clarify the frequency and clinical features of patients with SRS phenotype caused by PCNVs...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28514698/clinical-outcomes-and-frontal-plane-two-dimensional-biomechanics-during-the-30-second-single-leg-stance-test-in-patients-before-and-after-hip-abductor-tendon-reconstructive-surgery
#5
Rose E Huxtable, Timothy R Ackland, Gregory C Janes, Jay R Ebert
BACKGROUND: Hip abductor tendon tears are a common cause of Greater Trochanteric Pain Syndrome. Conservative treatments are often ineffective and surgical reconstruction may be recommended. This study investigated the improvement in clinical outcomes and frontal plane two-dimensional biomechanics during a 30-second single leg stance test, in patients undergoing reconstruction. We hypothesized that clinical scores and pertinent biomechanical variables would significantly improve post-surgery, and these outcomes would be significantly correlated...
May 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28513053/high-frequency-ultrasound-quantification-of-acute-radiation-dermatitis-pilot-study-of-patients-undergoing-radiotherapy-for-breast-cancer
#6
M Garnier, E Champeaux, E Laurent, A Boehm, O Briard, T Wachter, L Vaillant, F Patat, G Bens, L Machet
BACKGROUND: Acute radiation dermatitis (ARD) is a frequent complication after breast cancer radiotherapy and is usually assessed by semi-quantitative clinical scores, which may be subject to inter-observer variability. High-frequency ultrasound imaging of the skin can reliably quantify thickness and edema in diseased skin. We aimed to compare the relative increase in dermal thickness of the irradiated zone in breast-cancer patients undergoing radiotherapy, with clinical severity. METHODS: A consecutive series of patients undergoing treatment for breast cancer by lumpectomy and radiotherapy in a 6-month period also underwent clinical and ultrasound evaluation of ARD...
May 17, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28511945/low-rates-of-aseptic-tibial-loosening-in-obese-patients-with-use-of-high-viscosity-cement-and-standard-tibial-tray-2-year-minimum-follow-up
#7
David A Crawford, Keith R Berend, Denis Nam, Robert L Barrack, Joanne B Adams, Adolph V Lombardi
BACKGROUND: Total knee arthroplasty is overall a very successful surgery, but complications do occur. These complications include aseptic loosening of the tibial component, and obese patients are among the highest risk group. High-viscosity cement (HVC) has been implicated as a possible cause for aseptic loosening of the tibial component. The purpose of this study was to evaluate the incidence of aseptic loosening of the tibial component in obese patients with the use of HVC and standard tibial tray...
April 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28511420/effect-of-intraperitoneal-injection-of-saffron-on-the-treatment-of-experimental-endotoxin-induced-uveitis-in-the-rabbit
#8
Mohammad Reza Talebnejad, Kazem Soltanzadeh, Eghtedari Masoomeh, Masoud Yasemi, Mohammad Reza Khalili, Sherafat Maryam
INTRODUCTION: Saffron with scientific name of "Crocus sativus" from the family "Iridaceae" is a plant without stem and root. Antioxidative and immunomodulatory effects of saffron has been demonstrated in different studies. AIM: To assess the effects of saffron in the treatment on Lipopolysaccharide (LPS) induced uveitis in the rabbit. MATERIALS AND METHODS: Thirty healthy female New Zealand white rabbits were prepared. LPS induced uveitis was confirmed via slit lamp examination 24 hours after intravitreal injection of Salmonella typhimurium LPS endotoxin in the right eye of all rabbits...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511285/increased-f4-80-hi-macrophages-is-associated-with-suppression-of-serum-transfer-induced-arthritis-in-mice-with-flip-reduced-in-myeloid-cells
#9
Qi-Quan Huang, Robert Birket, Renee E Doyle, G Kenneth Haines, Harris Perlman, Bo Shi, Philip Homan, Lianping Xing, Richard M Pope
OBJECTIVE: Macrophages are critical in the pathogenesis of rheumatoid arthritis (RA). We recently demonstrated that FLIP (FLICE-like inhibitory protein) is necessary for the differentiation and/or survival of macrophages. We also identified that FLIP is highly expressed in RA synovial macrophages. This study was performed to determine if the reduction of Flip in macrophages would reduce synovial tissue macrophages and ameliorate serum transfer induced arthritis (STIA). METHODS: Mice with Flip deleted in myeloid cells (Flip(f/f) LysM(c/+) mice) and littermate controls were employed...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28509828/modular-fluted-tapered-stems-in-aseptic-revision-total-hip-arthroplasty
#10
Matthew P Abdel, Umberto Cottino, Dirk R Larson, Arlen D Hanssen, David G Lewallen, Daniel J Berry
BACKGROUND: Modular fluted tapered stems have become the most commonly employed category of femoral component in revision hip arthroplasty in North America as a result of favorable early results and simplicity of use. Despite wide adoption, the majority of published data are limited to relatively small series with modest follow-up. The goal of the current study was to determine the success rate and factors associated with success, failure, and complications of the use of modular fluted tapered stems in aseptic revision total hip arthroplasties (THAs) in a large patient cohort...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28508295/mri-based-tendon-bone-healing-is-related-to-the-clinical-functional-scores-at-the-first-year-after-anterior-cruciate-ligament-reconstruction-with-hamstring-tendon-autograft
#11
Hong-Yun Li, Hong Li, Zi-Ying Wu, Ji-Wu Chen, Shi-Yi Chen
PURPOSE: The correlation between tendon bone healing and clinical functional scores after anterior cruciate ligament reconstruction (ACLR) using four-stranded hamstring tendon autograft has rarely being reported. The purpose of this study was to determine the correlation between magnetic resonance imaging (MRI)-based tendon bone healing and clinical functional scores after ACLR using hamstring tendon. METHODS: Thirty-eight patients with ACLR using four-stranded hamstring tendon autograft were included in this prospective study in the authors' hospital from 2013 to 2014...
May 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28506308/attenuating-immune-pathology-using-a-microbial-based-intervention-in-a-mouse-model-of-cigarette-smoke-induced-lung-inflammation
#12
Mark Bazett, Agnieszka Biala, Ryan D Huff, Matthew R Zeglinksi, Philip M Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan, Jeremy A Hirota
BACKGROUND: Cigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing bronchodilation. However, these options have varying efficacy in controlling symptoms and do not reverse or limit the progression of COPD. Treatments strategies using bacterial-derived products have shown promise in diseases characterized by inflammation and immune dysfunction. This study investigated for the first time whether a novel immunotherapy produced from inactivated Klebsiella (hereafter referred to as KB) containing all the major Klebsiella macromolecules, could attenuate cigarette smoke exposure-induced immune responses...
May 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28503976/self-extubation-laryngeal-injuries-at-an-academic-tertiary-care-center-a-retrospective-pilot-study
#13
Jason E Cohn, Andrew Touati, Mark Lentner, Mark Weitzel, Casey Fisher, Robert T Sataloff
OBJECTIVES: The purpose of this study is to identify laryngeal symptoms and injuries in self-extubated patients. METHODS: A retrospective chart review was conducted to identify symptoms and clinical findings associated with self-extubation. A novel scoring system was developed and used to quantify these findings. Symptom score included all symptoms that patients reported after self-extubation. Clinical score consisted of laryngeal findings visualized on nasopharyngeal laryngoscopy...
May 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28502536/results-of-a-modular-revision-system-in-total-knee-arthroplasty
#14
David A Crawford, Keith R Berend, Michael J Morris, Joanne B Adams, Adolph V Lombardi
BACKGROUND: Revision total knee arthroplasty (TKA) poses unique challenges compared with primary TKA such as bone loss, deformity, and ligament instability. Modular component options allow flexibility to deal with these complexities. The purpose of this study was to evaluate midterm outcomes for revision TKA using a modular revision knee system with complete interchangeability and multiple options for augmentation, offset, constraint, and stem extensions. METHODS: A query of our practice registry revealed 257 consented patients (274 knees and 278 TKA) with minimum 2-year follow-up who underwent aseptic revision TKA with a modular system (Vanguard Super Stabilized Knee; Zimmer Biomet, Warsaw, IN) between 2005 and 2013...
April 10, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28499934/matrine-promotes-oligodendrocyte-development-in-cns-autoimmunity-through-the-pi3k-akt-signaling-pathway
#15
Shuqing Liu, Mingliang Zhang, Huijun Zhang, Fangzhou Liu, Raojuan Chu, Guang-Xian Zhang, Lin Zhu
AIMS: Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, has been recently found to be beneficial in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, mainly through its anti-inflammatory effect. In the present study, we tested the effect of MAT on ongoing EAE and defined possible mechanisms underlying its effects on myelination and oligodendrocytes. MAIN METHODS: EAE was induced in C57BL/6 mice and MAT treatment was started at disease onset...
May 9, 2017: Life Sciences
https://www.readbyqxmd.com/read/28495197/randomized-allopurinol-controlled-trial-of-the-effects-of-dietary-nucleotides-and-active-hexose-correlated-compound-in-the-treatment-of-canine-leishmaniosis
#16
Sergi Segarra, Guadalupe Miró, Ana Montoya, Luis Pardo-Marín, Noemí Boqué, Lluis Ferrer, José Cerón
First-line treatment for canine leishmaniosis (CanL) is N-methylglucamine antimoniate (MGA) combined with allopurinol. However, in some dogs allopurinol may induce hyperxanthinuria leading to urolithiasis. Moreover, allopurinol resistance has recently been described in Leishmania infantum isolates from treated dogs with a relapse of the disease. Alternative treatments are thus needed. Since the type of host immune response strongly influences CanL progression and prognosis, dogs could benefit from treatments targeted at modulating such response, such as nucleotides and active hexose correlated compound (AHCC)...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28492915/sildenafil-treatment-in-heart-failure-with-preserved-ejection-fraction-targeted-metabolomic-profiling-in-the-relax-trial
#17
Hanghang Wang, Kevin Anstrom, Olga Ilkayeva, Michael J Muehlbauer, James R Bain, Steven McNulty, Christopher B Newgard, William E Kraus, Adrian Hernandez, G Michael Felker, Margaret Redfield, Svati H Shah
Importance: Phosphodiesterase-5 inhibition with sildenafil compared with a placebo had no effect on the exercise capacity or clinical status of patients with heart failure with preserved ejection fraction (HFpEF) in the PhosphodiesteRasE-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure with Preserved Ejection Fraction (RELAX) clinical trial. Metabolic impairments may explain the neutral results. Objective: To test the hypothesis that profiling metabolites in the RELAX trial would clarify the mechanisms of sildenafil effects and identify metabolites associated with clinical outcomes in HFpEF...
May 10, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28490654/early-skin-denervation-in-hereditary-and-iatrogenic-transthyretin-amyloid-neuropathy
#18
Teruaki Masuda, Mitsuharu Ueda, Genki Suenaga, Yohei Misumi, Masayoshi Tasaki, Ayane Izaki, Yukako Yanagisawa, Yasuteru Inoue, Hiroaki Motokawa, Sayaka Matsumoto, Mayumi Mizukami, Aiko Arimura, Takahisa Deguchi, Yoshihiko Nishio, Taro Yamashita, Yukihiro Inomata, Konen Obayashi, Yukio Ando
OBJECTIVE: To elucidate early skin denervation in hereditary transthyretin (TTR) amyloidosis and iatrogenic TTR amyloidosis. METHODS: We investigated intraepidermal nerve fiber density (IENFD) and clinical findings in 32 patients with hereditary TTR amyloidosis, 11 asymptomatic mutation carriers, 6 patients with iatrogenic TTR amyloidosis, and 23 healthy volunteers. RESULTS: IENFD values were reduced in patients with the V30M mutation (1.9 ± 2...
May 10, 2017: Neurology
https://www.readbyqxmd.com/read/28486971/a-role-for-cathepsin-z-in-neuroinflammation-provides-mechanistic-support-for-an-epigenetic-risk-factor-in-multiple-sclerosis
#19
Euan R O Allan, Rhiannon I Campden, Benjamin W Ewanchuk, Pankaj Tailor, Dale R Balce, Neil T McKenna, Catherine J Greene, Amy L Warren, Thomas Reinheckel, Robin M Yates
BACKGROUND: Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenting cells. While cathepsin Z expression has been associated with neuroinflammatory disorders, a role for cathepsin Z in mediating neuroinflammation has not been previously established. METHODS: Experimental autoimmune encephalomyelitis (EAE) was induced in both wildtype mice and mice deficient in cathepsin Z...
May 10, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28480797/tnf%C3%AE-depleting-therapy-improves-fertility-and-animal-welfare-in-tnf%C3%AE-driven-transgenic-models-of-polyarthritis-when-administered-in-their-routine-breeding
#20
Amy J Naylor, Guillaume Desanti, Atif N Saghir, Rowan S Hardy
Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNF(ΔARE) mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and inflammation in these models represents a significant detriment to breeding management. We examined whether TNFα depleting therapy 'infliximab' might represent a significant refinement in routine breeding. Clinical scores of joint inflammation were assessed in TNF(ΔARE) males receiving either infliximab (10 mg/kg) or saline by twice-weekly intraperitoneal injection...
January 1, 2017: Laboratory Animals
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