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Perineural invasion Or PNI

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https://www.readbyqxmd.com/read/28916388/differential-effects-of-fxr-or-tgr5-activation-in-cholangiocarcinoma-progression
#1
O Erice, I Labiano, A Arbelaiz, A Santos-Laso, P Munoz-Garrido, R Jimenez-Agüero, P Olaizola, A Caro-Maldonado, N Martín-Martín, A Carracedo, E Lozano, J J Marin, C J O'Rourke, J B Andersen, J Llop, V Gómez-Vallejo, D Padro, A Martin, M Marzioni, L Adorini, M Trauner, L Bujanda, M J Perugorria, J M Banales
BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is an aggressive tumor type affecting cholangiocytes. CCAs frequently arise under certain cholestatic liver conditions. Intrahepatic accumulation of bile acids may facilitate cocarcinogenic effects by triggering an inflammatory response and cholangiocyte proliferation. Here, the role of bile acid receptors FXR and TGR5 in CCA progression was evaluated. METHODS: FXR and TGR5 expression was determined in human CCA tissues and cell lines...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28892911/benign-beale-gland-hyperplasia-mimicking-malignant-biliary-obstruction
#2
Durairaj Segamalai, Anand Lakshmanan, Abdul Rehman Abdul Jameel, Sofiya Chandrabapulu, Kannan Devy Gounder
Extrahepatic bile duct obstruction can be caused by various pathologies, most of them being malignant. Painless, progressive jaundice is the usual mode of presentation. We report a case of distal Common Bile Duct (CBD) obstruction due to a Benign Intramural Beale gland hyperplasia mimicking a periampullary carcinoma. Peribiliary glands (Beale Glands) are a group of seromucinous glands, normally seen within the fibromuscular wall and periductal connective tissue in the extrahepatic and large intrahepatic ducts and also in the neck of the Gall bladder...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28882673/predictive-factors-for-local-recurrence-after-glansectomy-and-neoglans-reconstruction-for-penile-squamous-cell-carcinoma
#3
Maarten Albersen, Arie Parnham, Steven Joniau, Varun Sahdev, Michelle Christodoulidou, Fabio Castiglione, Raj Nigam, Peter Malone, Alex Freeman, Charles Jameson, Suks Minhas, David J Ralph, Asif Muneer
OBJECTIVES: To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy. PATIENTS AND METHODS: In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penile cancer center in the UK for LR after glansectomy and glans reconstruction. Univariate and multivariate Cox proportional hazards regression was used to identify 4 prognostic indicators for LR...
September 4, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28881811/akt-can-modulate-the-in-vitro-response-of-hnscc-cells-to-irreversible-egfr-inhibitors
#4
Renato José Silva-Oliveira, Matias Melendez, Olga Martinho, Maicon F Zanon, Luciano de Souza Viana, André Lopes Carvalho, Rui Manuel Reis
Epidermal growth factor receptor (EGFR) is overexpressed in up to 90% of head and neck squamous cell carcinoma (HNSCC) tumors. Cetuximab is the first targeted (anti-EGFR) therapy approved for the treatment of HNSCC patients. However, its efficacy is limited due to primary and secondary resistance, and there is no predict biomarkers of response. New generation of EGFR inhibitors with pan HER targeting and irreversible action, such as afatinib and allitinib, represents a significant therapeutic promise. In this study, we intend to compare the potential cytotoxicity of two anti-EGFR inhibitors (afatinib and allitinib) with cetuximab and to identify potential predictive biomarkers of response in a panel of HNSCC cell lines...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881357/a-novel-inhibitory-anti-invasive-mab-isolated-using-phenotypic-screening-highlights-anxa6-as-a-functionally-relevant-target-protein-in-pancreatic-cancer
#5
Dermot O'Sullivan, Paul Dowling, Helena Joyce, Edel McAuley, Andrew McCann, Michael Henry, Brianan McGovern, Paul Barham, Fergal C Kelleher, Jean Murphy, Susan Kennedy, Niall Swan, Michael Moriarty, Martin Clynes, Annemarie Larkin
BACKGROUND: Discovery and validation of new antibody tractable targets is critical for the development of new antibody therapeutics to address unmet needs in oncology. METHODS: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate monoclonal antibodies (MAbs), which were screened for anti-invasive activity against aggressive cancer cells in vitro. The molecular target of selected inhibitory MAb 9E1 was identified using immunoprecipitation/liquid chromatography-tandem mass spectrometry...
September 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28879643/adenoid-cystic-carcinoma-of-the-oral-cavity-radiology-pathology-correlation
#6
Imran Uraizee, Nicole A Cipriani, Daniel T Ginat
Adenoid cystic carcinoma in the oral cavity is an uncommon salivary gland malignancy that has a propensity for perineural spread. A high-grade variant is evidenced by an abundance of pleomorphic cells, loss of the classic biphasic epithelial-myoepithelial growth pattern, and comedonecrosis, as well as elevated Ki-67. CT and MRI can both be useful for demonstrating the extent of invasion in oral cavity-associated adenoid cystic carcinoma, which can attain the inferior alveolar nerve for perineural spread by direct invasion through the mandible...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28877806/national-disparities-in-surgical-approach-to-t1-rectal-cancer-and-impact-on-outcomes
#7
Emmanuel Gabriel, Pragatheeshwar Thirunavukarasu, Eisar Al-Sukhni, Kristopher Attwood, Steven J Nurkin
This study investigated disparities between patients who had local excision versus radical resection for T1 rectal cancer. A retrospective analysis was performed using the National Cancer Data Base, 2004 to 2011. Inclusion criteria consisted of patients with T1, N0 rectal adenocarcinoma that were <3 cm, well or moderately differentiated without perineural invasion. Patients were stratified based on local excision and radical surgery. The primary outcome was overall survival (OS). Secondary outcomes included 30-day mortality, unplanned readmission rates, and postoperative length of stay...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28875312/indication-of-extrahepatic-bile-duct-resection-for-gallbladder-cancer
#8
Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Shinichiro Mori, Takaaki Arigami, Yuko Kijima, Hiroyuki Shinchi, Shoji Natsugoe
PURPOSE: Extrahepatic bile duct (EHBD) resection is performed as part of radical cholecystectomy for gallbladder (GB) cancer. However, the indication for EHBD resection is still controversial. The aim of the present study was to evaluate the prognostic value of this procedure. METHODS: Patients who underwent surgical resection for GB cancer with curative intent were enrolled. We divided GB cancer into two categories based on the tumor location: proximal-type and distal-type tumors...
September 5, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28874120/the-association-between-smoking-and-breast-cancer-characteristics-and-outcome
#9
Hadar Goldvaser, Omer Gal, Shulamith Rizel, Daniel Hendler, Victoria Neiman, Tzippy Shochat, Aaron Sulkes, Baruch Brenner, Rinat Yerushalmi
BACKGROUND: Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of smoking on breast cancer characteristics is limited. We evaluated the impact of smoking on breast cancer characteristics and outcome. METHODS: This was a retrospective single center study. All women diagnosed from 4/2005 through 3/2012 and treated in our institute for early, estrogen receptor positive, human epidermal growth factor receptor 2 (HER2) negative breast cancer, whose tumors were sent for Oncotype DX analysis were included...
September 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28873240/gastric-poorly-cohesive-carcinoma-a-correlative-study-of-mutational-signatures-and-prognostic-significance-based-on-histopathologic-subtypes
#10
Chae Hwa Kwon, Young Keum Kim, Sojeong Lee, Ahrong Kim, Hye Ji Park, Yuri Choi, Yeo Jin Won, Do Youn Park, Gregory Y Lauwers
AIMS: Genome-wide next-generation sequencing has revealed several driver mutations and allows establishing a molecular taxonomy of gastric cancer. However, correlation between the broad mutational spectrum of gastric cancer and its various clinicopathological characteristics has yet to be fully elucidated. METHODS AND RESULTS: Herein, we analyzed the mutational pattern of 77 genes in a cohort of 91 patients with poorly cohesive carcinoma using targeted sequencing and evaluated the clinicopathological significance of the various mutations based its histologic pattern, either signet ring cell (SRC) or other types of poorly cohesive carcinoma (not otherwise specified) (PCC-NOS)...
September 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28870928/outcomes-and-prognostic-factors-of-resected-salivary-gland-malignancies-examining-a-single-institution-s-12-year-experience
#11
Tyler Gutschenritter, Michael Machiorlatti, Sara Vesely, Bilal Ahmad, Wajeeha Razaq, Mohammad Razaq
BACKGROUND: Despite adjuvant radiotherapy, survival outcomes remain poor in patients with salivary gland malignancies who have multiple poor prognostic factors. This study aimed to determine which patients may benefit from treatment intensification. PATIENTS AND METHODS: Patients who underwent curative resection with or without adjuvant radiotherapy between 2002 and 2014 were identified and a retrospective chart review was performed. Overall survival (OS) and disease-free survival (DFS) were the main outcomes measured...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28864348/acquisition-of-histologic-diversity-contributes-to-not-only-invasiveness-but-also-lymph-node-metastasis-in-early-gastric-cancer
#12
Hyoun Wook Lee, Kyungeun Kim
BACKGROUND: As more endoscopic resections are performed in early gastric cancer, the pretreatment prediction of lymph node metastasis (LNM) becomes more important. Some tumor characteristics including histologic type, invasion depth, ulceration, size, and lymphovascular invasion have been used to determine the endoscopic resectability of early gastric cancer; however, a more detailed analysis between clinicopathologic factors and lymph node metastasis is needed. METHODS: We analyzed the correlation between the clinicopathological findings and LNM with 310 cases of early gastric cancer by dividing invasion depths in detail...
August 25, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28858385/pathological-factors-impacting-prognosis-of-resected-liver-metastases-of-colorectal-carcinoma-implications-and-proposal-for-a-pathological-reporting-protocol
#13
REVIEW
Gilton Marques Fonseca, Paulo Herman, Sheila Friedrich Faraj, Jaime Arthur Pirola Kruger, Fabricio Ferreira Coelho, Vagner Birk Jeismann, Ivan Cecconello, Venancio Avancini Ferreira Alves, Timothy M Pawlik, Evandro Sobroza de Mello
Colorectal cancer is a leading cause of death worldwide. The liver is the most common site of distant metastases and surgery is the only potentially curative treatment, although recurrence following surgery is high. In order to define prognosis after surgery, many histopathological features have been identified in the primary tumor. In turn, pathologists routinely report specific findings to guide oncologists about the decision to recommend adjuvant therapy. In general, the pathological report of resected colorectal liver metastases is limited to confirmation of the malignancy and details regarding the margins status...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28854970/egfr-copy-number-alterations-in-primary-tumors-metastatic-lymph-nodes-and-recurrent-and-multiple-primary-tumors-in-oral-cavity-squamous-cell-carcinoma
#14
Shiang-Fu Huang, Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao, Hung-Ming Wang
BACKGROUND: The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invasion. Therefore, we hypothesized that EGFR gene copy number alteration in the primary tumor could predict amplification in recurrent tumors, lymph node metastatic foci or secondary primary tumors...
August 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28842810/rectal-cancer-in-patients-under-50%C3%A2-years-of-age
#15
A M Dinaux, L G J Leijssen, L G Bordeianou, H Kunitake, D L Berger
BACKGROUND: General population screening for colorectal cancer starts at 50, and incidence rates of rectal cancer in patients over 50 years old are decreasing. However, incidence of rectal cancer under age 50 is increasing. This paper analyzes short-and long-term outcomes for rectal cancer patients under 50 years of age. METHODS: Retrospective analyses of consecutive patient cohort, who all received surgical treatment for primary rectal adenocarcinoma at a single institute were used in the study...
August 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28840497/defining-long-term-survivors-following-resection-of-intrahepatic-cholangiocarcinoma
#16
Fabio Bagante, Gaya Spolverato, Matthew Weiss, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is an aggressive primary tumor of the liver. While surgery remains the cornerstone of therapy, long-term survival following curative-intent resection is generally poor. The aim of the current study was to define the incidence of actual long-term survivors, as well as identify clinicopathological factors associated with long-term survival. METHODS: Patients who underwent a curative-intent liver resection for ICC between 1990 and 2015 were identified using a multi-institutional database...
August 24, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28838425/lymph-node-ratio-relationship-to-regional-failure-and-distant-metastases-in-oral-cavity-cancer
#17
Ali Hosni, Caitlin McMullen, Shao Hui Huang, Wei Xu, Jie Su, Andrew Bayley, Scott V Bratman, John Cho, Meredith Giuliani, John Kim, Jolie Ringash, John Waldron, Anna Spreafico, Ilan Weinreb, John R de Almeida, Dale H Brown, Jonathan C Irish, Brian O'Sullivan, David P Goldstein, Andrew Hope
BACKGROUND: We aimed to investigate the impact of lymph node ratio (LNR, number of positive nodes/total number of excised nodes) on regional-only-failure, distant-only-failure and overall survival (OS) in oral squamous cell carcinoma (OSCC). METHODS: Retrospective review of pN0-2 OSCC-patients (1994-2012) treated with curative-surgery with neck dissection±postoperative radiotherapy (PORT)±concurrent chemotherapy. LNR was subjected to multivariable analysis (MVA) of regional-only-failure, distant-only-failure and OS...
August 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28831266/prognosis-of-neutrophil-to-lymphocyte-ratio-in-clinical-early-stage-tongue-ct1-t2n0-cancer
#18
Ching-Nung Wu, Hui-Ching Chuang, Yu-Tsai Lin, Fu-Min Fang, Shau-Hsuan Li, Chih-Yen Chien
BACKGROUND: Inflammation plays a role in the development of cancer. This study aims to analyze the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and other clinicopathological determinants in early-stage (cT1/T2N0) tongue cancer. MATERIALS AND METHODS: A total of 262 patients were selected from our institute's cancer database between 2004 and 2011. Optimal cutoff value of NLR and lymph node density (LND) were determined statistically using receiver operating characteristic curve analysis for survival prediction...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28828692/systemic-inflammation-response-index-siri-cancer-stem-cells-and-survival-of-localised-gastric-adenocarcinoma-after-curative-resection
#19
Sen Li, Xiuwen Lan, Hongyu Gao, Zhiguo Li, Li Chen, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yingwei Xue
PURPOSE: Systemic Inflammation Response Index (SIRI), based on peripheral neutrophil, monocyte, and lymphocyte counts, was recently developed and used as a marker to predict the survival of patients with malignant tumours. Cancer stem cells (CSCs) can contribute to gastric cancer progression and recurrence. It is not clear whether SIRI is associated with CSCs during gastric cancer development. METHODS: The SIRI was developed in a training cohort of 455 gastric cancer patients undergoing curative resection between 2007 and 2009, and validated in a validation cohort of 327 patients from 2010 to 2011...
August 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28820280/review-of-periorbital-nerve-enlargement-and-biopsy-techniques
#20
Valerie H Chen, Brent R Hayek, Hans E Grossniklaus, Ted H Wojno, H Joon Kim
Periorbital nerve enlargement commonly indicates perineural invasion of malignancy or inflammatory conditions. This study reviews the role of supraorbital and infraorbital nerve biopsies in patients presenting with radiographic enlargement and to elucidate the surgical technique involved. A retrospective chart review (1997-2014) was performed at a single tertiary center. Patients with radiographic confirmation of enlarged supraorbital/infraorbital nerves that underwent biopsy were included. Charts were reviewed for: patient demographics and history, clinical symptoms and findings, radiographic findings, surgical method, and treatment...
August 18, 2017: Orbit
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