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Perineural invasion Or PNI

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https://www.readbyqxmd.com/read/29337642/perineural-invasion-in-parotid-gland-malignancies
#1
Phillip Huyett, Umamaheswar Duvvuri, Robert L Ferris, Jonas T Johnson, Barry M Schaitkin, Seungwon Kim
Objectives To investigate the clinical predictors and survival implications of perineural invasion (PNI) in parotid gland malignancies. Study Design Case series with chart review. Setting Tertiary care medical center. Subjects and Methods Patients with parotid gland malignancies treated surgically from 2000 to 2015 were retrospectively identified in the Head and Neck Cancer Registry at a single institution. Data points were extracted from the medical record and original pathology reports. Results In total, 186 patients with parotid gland malignancies were identified with a mean follow-up of 5...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29336202/the-prediction-value-of-the-systemic-inflammation-score-for-oral-cavity-squamous-cell-carcinoma
#2
Yousif I Eltohami, Huang-Kai Kao, William Wei-Kai Lao, Yenlin Huang, Mohamed Abdelrahman, Chun-Ta Liao, Tzu-Chen Yen, Kai-Ping Chang
Objectives This study aimed to investigate the potential prognostic role of the oral cancer systemic inflammation score (SIS) based on serum albumin levels and the lymphocyte-to-monocyte ratio in patients with oral squamous cell carcinoma (OSCC) after treatment. Study Design A retrospective cohort study. Setting Tertiary care center. Subjects and Methods The study involved 613 patients who were treated for OSCC between September 2005 and December 2014. The association of the oral cancer SIS with various clinicopathological features was investigated...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29322269/prognostic-value-of-simultaneous-18f-fdg-pet-mri-using-a-combination-of-metabolo-volumetric-parameters-and-apparent-diffusion-coefficient-in-treated-head-and-neck-cancer
#3
Yong-Il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee, June-Key Chung
BACKGROUND: The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters...
January 10, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29315911/promoter-hypermethylation-of-sox11-correlates-with-adverse-clinicopathological-features-of-human-prostate-cancer
#4
Apiwat Pugongchai, Andrey Bychkov, Pichet Sampatanukul
Currently available tools for early diagnosis and prognosis of prostate cancer lack sufficient accuracy. There is a need to identify novel biomarkers for this common malignancy. SOX family genes play an important role in embryogenesis and are also implicated in various cancers. SOX11 has been recently recognized as a potential tumour suppressor that is downregulated in prostate cancer. We hypothesized that hypermethylation may be responsible for SOX11 silencing in human prostate cancer. The aim of the study was to investigate SOX11 promoter methylation in prostate adenocarcinoma by comparing it with benign prostatic hyperplasia (BPH)...
January 8, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29313371/utility-of-3-month-surveillance-f-18-fdg-pet-ct-in-surgically-resected-oral-squamous-cell-carcinoma
#5
Michael Marquardt, Carryn Anderson, Timothy Ginader, Jessica Parkhurst, Nitin Pagedar, Rodrigo Bayon, Gerald Clamon, Andrew Hoover, John Buatti
OBJECTIVES: To evaluate the performance of surveillance F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) 1 year after imaging in oral squamous cell carcinoma (OSCC) patients treated with definitive surgery and adjuvant (chemo)radiotherapy (RT). METHODS AND MATERIALS: Surveillance PET/CT accuracy was retrospectively evaluated in OSCC patients receiving surgical resection and (chemo)RT. Pathologic risk factors were assessed for influence on accuracy of the post-RT PET/CT...
January 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29302376/clinicopathological-significance-of-large-tumor-suppressor-lats-expression-in-gastric-cancer
#6
Myoung Won Son, Geum Jong Song, Si-Hyong Jang, Soon Auck Hong, Mee-Hye Oh, Ji-Hye Lee, Moo Jun Baek, Moon Soo Lee
Purpose: The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate the clinicopathological significance of LATS expression and its correlation with overall survival (OS). Materials and Methods: LATS1 and LATS2 expression in a tissue microarray was detected by immunohistochemistry, using 264 gastric cancer specimens surgically resected between July 2006 and December 2009...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29299363/does-histology-really-influence-gastric-cancer-prognosis
#7
Carrie Luu, Ram Thapa, Katherine Woo, Domenico Coppola, Khaldoun Almhanna, Jose M Pimiento, Dung-Tsa Chen, Daissy Dominguez Marquez, Pamela J Hodul
Background: Gastric cancer (GC) is associated with poor survival despite curative-intent surgical resection and systemic therapy. Our objective is to examine the impact of histology on prognosis as well as the impact of linitis plastica (LP) on survival. Methods: The GC database at a single institution was evaluated for patients who underwent resection from 2000 to 2015. Clinicopathologic characteristics were examined and descriptive statistics was used to analyze four groups of patients based on Lauren classification: intestinal (n=93), diffuse (n=20), diffuse with signet-ring cell features (n=57), and LP (n=40)...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29299357/the-correlations-between-serum-amphiregulin-and-other-clinicopathological-factors-in-colorectal-cancer
#8
Chawalit Chayangsu, Siriporn Khunsri, Virote Sriuranpong, Suebpong Tanasanvimon
Background: Amphiregulin (AREG) is one of the epidermal growth factor receptor (EGFR) ligands and plays the important roles in tumor progression and metastasis. Upregulation of AREG in colorectal cancer (CRC) tissues has been shown to correlate with depth of tumor invasion, nerve invasion and liver metastasis. We sought to investigate a correlation of serum AREG in CRC with clinicopathological parameters. Methods: Patients with CRC receiving treatment at King Chulalongkorn Memorial Hospital during August 2013 to March 2014 were enrolled...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29297497/prostate-cancer-reporting-and-staging-needle-biopsy-and-radical-prostatectomy-specimens
#9
David J Grignon
Prostatic adenocarcinoma remains the most common cancer affecting men. A substantial majority of patients have the diagnosis made on thin needle biopsies, most often in the absence of a palpable abnormality. Treatment choices ranging from surveillance to radical prostatectomy or radiation therapy are largely driven by the pathologic findings in the biopsy specimen. The first part of this review focuses on important morphologic parameters in needle biopsy specimens that are not covered in the accompanying articles...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29297490/prostate-cancer-diagnostic-criteria-and-role-of-immunohistochemistry
#10
Cristina Magi-Galluzzi
The diagnosis of prostate cancer is based on microscopic criteria. Presently, prostate needle biopsy interpretation can be a challenge for the pathologist due to the increased number of specimens with limited amount of suspicious glands and minimal atypia. It is critical for the pathologist to have an organized methodical approach when considering the morphological features enabling a definitive diagnosis of prostate cancer. Although several diagnostic criteria and supportive features have been advocated, only few findings are absolutely specific and diagnostic of prostate cancer...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29277385/outcomes-of-resection-for-solitary-%C3%A2-5%C3%A2-cm-intrahepatic-cholangiocarcinoma
#11
Paola Tarchi, Parissa Tabrizian, Jake Prigoff, Myron Schwartz
BACKGROUND: Resection remains the treatment of choice achieving 5-year survival rates of 22% to 40%. The aim of this analysis was to examine the outcomes of patients with solitary ≤5 cm intrahepatic cholangiocarcinoma. METHODS: A retrospective chart review was performed on 123 patients undergoing resection for primary intrahepatic cholangiocarcinoma from 1995 to 2013. Group 1 included patients with asymptomatic solitary intrahepatic cholangiocarcinoma measuring ≤5 cm...
December 22, 2017: Surgery
https://www.readbyqxmd.com/read/29274778/inhibition-of-cx3cr1-reduces-cell-motility-and-viability-in-pancreatic-adenocarcinoma-epithelial-cells
#12
Matthew C Stout, Shilpa Narayan, Emily S Pillet, Joseph M Salvino, Paul M Campbell
Increased expression of the chemokine CX3CL1 and its sole receptor, CX3CR1 have been correlated with poor pancreatic cancer patient survival and time to recurrence, as well as with pancreatic perineural invasion. We have previously shown that metastasis of prostate and breast cancer is in part driven by CX3CL1, and have developed small molecule inhibitors against the CX3CR1 receptor that diminish metastatic burden. Here we ask if inhibition of this chemokine receptor affects the phenotype of PDAC tumor cells...
December 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29274041/intraoral-pigmented-low-grade-adenocarcinoma-not-otherwise-specified-case-report-and-immunohistochemical-study
#13
Jessica Luana Dos Santos, Albina Messias de Almeida Milani Altemani, Alexandre Elias Trivellato, Cássio Edvard Sverzut, Luciana Yamamoto Almeida, Lucas Ribeiro Teixeira, Alfredo Ribeiro-Silva, Jorge Esquiche León
Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29249272/successful-spinal-anaesthesia-in-a-patient-with-a-tarlov-cyst
#14
N Pfund, A Oh, A Cyna
Perineural (Tarlov) cysts are cerebrospinal fluid-containing perineural sacs that are usually located in the sacral spine. While often asymptomatic, they can cause progressive neurological symptoms including pain, paraesthesia and weakness. We present a case of a 24-year-old patient who had uneventful spinal anaesthesia at the L3-4 level for an elective caesarean section. Prior to her procedure, she had reported a two-year history of intermittent back pain and lower-limb paraesthesia, secondary to an S1 segment perineural cyst...
December 14, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29223019/are-pathological-high-risk-features-in-locally-advanced-rectal-cancer-a-useful-selection-tool-for-adjuvant-chemotherapy
#15
Marloes Swets, Peter J K Kuppen, Erik J Blok, Hans Gelderblom, Cornelis J H van de Velde, Iris D Nagtegaal
BACKGROUND: Several histological high-risk factors are used as an indication for adjuvant therapy in stage II colon cancer. Those and other factors, including lymphatic invasion, perineural invasion (PNI), venous invasion and tumour budding are associated with decreased outcome. In this study, we evaluated the prognostic and predictive values of these biomarkers in a cohort of rectal cancer patients. MATERIALS AND METHODS: The trial-based cohort consisted of 221npTNM stage II-III rectal cancer patients, included in the PROCTOR/SCRIPT trial, a multicentre randomised phase III trial...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29216709/effect-of-adjuvant-chemotherapy-on-stage-ii-colon-cancer-analysis-of-korean-national-data
#16
Min Ki Kim, Daeyoun David Won, Sun Min Park, Taejung Kim, Sung Ryong Kim, Seong Taek Oh, Seung Kook Sohn, Mi Yeon Kang, In Kyu Lee
Purpose: Debates exist regarding the effectiveness of adjuvant chemotherapy for stage II colon cancer. This study aimed to investigate the current status of adjuvant chemotherapy and its impact on survival for Korean stage II colon cancer patients by analyzing the National Quality Assessment data. Methods: A total of 7880 patients who underwent curative resection for stage II colon adenocarcinoma between January 2011 and December 2014 in Korea were selected randomly as evaluation subjects for the quality assessment...
December 7, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29207615/pik3ca-mutations-are-associated-with-increased-tumor-aggressiveness-and-akt-activation-in-gastric-cancer
#17
Ji-Won Kim, Hye Seung Lee, Kyung Han Nam, Soyeon Ahn, Jin Won Kim, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Keun-Wook Lee
PIK3CA mutations are frequent in gastric cancer. However, their pathological and clinical implications are still unclear. We analyzed the clinicopathological characteristics according to the PIK3CA mutation status of patients with stage IB-IV disease who underwent gastrectomy between May 2003 and Dec. 2005 (cohort 1; n = 302) and of those with stage IV disease who received gastrectomy between Jul. 2006 and Dec. 2012 (cohort 2; n = 120). PIK3CA mutations were detected in 40 patients (13.2%) in cohort 1. In these patients, PIK3CA-mutant tumors were more frequently located in the upper third of the stomach (p = 0...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203074/microscopic-biliary-and-perineural-invasion-and-clinical-outcome-after-neoadjuvant-bevacizumab-based-chemotherapy-and-liver-resection-in-patients-with-colorectal-liver-metastases
#18
Judith Stift, Alexandra Graf, Christoph Schwarz, Dietmar Tamandl, Patrick Starlinger, Merima Herac, Andrea Beer, Friedrich Wrba, Martin Bodingbauer, Klaus Kaczirek, Stefan Stremitzer
BACKGROUND: The value of microscopic biliary and perineural invasion as prognostic biomarkers in patients with resectable colorectal liver metastases (CLM) who undergo neoadjuvant chemotherapy and liver resection is still unclear. This retrospective study was performed to elucidate this issue. METHODS: Histologic slides of resected CLM of patients who underwent neoadjuvant bevacizumab-based chemotherapy and liver resection were investigated with respect to biliary and perineural invasion...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29199015/contemporary-prognostic-indicators-for-prostate-cancer-incorporating-international-society-of-urological-pathology-recommendations
#19
REVIEW
Lars Egevad, Brett Delahunt, Glen Kristiansen, Hemamali Samaratunga, Murali Varma
Prognostic assessment is a key element in the management of patients with prostate cancer as it informs both treatment, follow-up and outcome prediction. Tumour grade should be based upon the novel and evidence-based recommendations of the International Society of Urological Pathology (ISUP) Consensus Conference of 2014, with ISUP grades 1-5 being derived from 2005 ISUP modified Gleason grading, i.e., ISUP grade 1 (3 + 3 = 6), grade 2 (3 + 4 = 7), grade 3 (4 + 3 = 7), grade 4 (3 + 5 = 8, 5 + 3 = 8, 4 + 4 = 8), and grade 5 (4 + 5 = 9 5 + 4 = 9, 5 + 5 = 10)...
November 30, 2017: Pathology
https://www.readbyqxmd.com/read/29194286/desmoplastic-melanoma-of-the-periorbital-region
#20
Sudip Thakar, Thomas Kandl, Oded Sagiv, Devjyoti Tripathy, Michael T Tetzlaff, Sahil Kapur, Jeffrey Myers, Wen-Jen Hwu, Bita Esmaeli, Bashar M Y Jaber
Desmoplastic melanoma (DM) is a rare subtype of melanoma and an even smaller proportion of periocular melanomas. Here, the authors report 2 cases of DM in the periocular region. Staged according to the American Joint Committee on Cancer (AJCC) eighth edition classification, patient 1 presented with a stage IIIC (pT4apN1cM0) DM in the left lateral canthus with upper and lower eyelid and patient 2 presented with a stage IIIB (T4aN1bM0) DM in the left brow and supraorbital region with a parotid lymph node metastasis...
November 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
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