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Perineural invasion Or PNI

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https://www.readbyqxmd.com/read/29138933/population-based-screening-improves-histopathological-prognostic-factors-in-colorectal-cancer
#1
Mónica Mengual-Ballester, Enrique Pellicer-Franco, Graciela Valero-Navarro, Victoriano Soria-Aledo, José Andrés García-Marín, José Luis Aguayo-Albasini
INTRODUCTION: Diagnosis of colorectal cancer (CRC) based on clinical symptoms is usually established in its advanced stages. One strategy for reducing mortality is the early detection and removal of preneoplastic and initial neoplastic lesions, even before the first symptoms appear, by means of population-based screening campaigns. The aim of the present study is to determine whether CRC diagnosed via a screening campaign has more favourable histopathological prognostic factors than when diagnosed in the symptomatic phase...
November 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29137049/garcin-syndrome-caused-by-parotid-gland-adenoid-cystic-carcinoma-a-case-report
#2
Nian-Ge Xia, Yan-Yan Chen, Xin-Shi Wang, Hui-Qin Xu, Rong-Yuan Zheng
RATIONALE: Garcin syndrome is characterized by the gradual involvement, and ultimately, unilateral paralysis of at least 7 and sometimes all cranial nerves, without intracranial hypertension or any long tract signs. PATIENT CONCERNS: We report the case of a 59-year-old woman who presented with Garcin syndrome, which gradually progressed over a period of 2 years. DIAGNOSIS: A left parotid gland biopsy revealed parotid gland adenoid cystic carcinoma (PGACC) with perineural invasion of a peripheral nerve bundle and lymph node metastasis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135102/changes-in-18f-fdg-pet-ct-tumor-metabolism-are-not-consistent-with-pathologic-complete-response-in-hormone-positive-breast-cancer
#3
Serap Kaya, Bilge Aktas, Eda Tanrikulu Sismek, Mehmet Akif Ozturk, Fuat Dede, Handan Kaya, Umit Ugurlu, Zerrin Ozgen, Sinan Koca, Suleyman Halil, Rahib Hasanov, Ozkan Alan, Nalan Akgul Babacan, Ozlem Ercelep, Faysal Dane, Mahmut Gumus, Fulden Yumuk
PURPOSE: Current evaluation of response to neoadjuvant chemotherapy (NAC) shows that it could achieve pathological complete response (pCR). The purpose of this study was to assess the consistency of maximum uptake values (SUVmax) changes and pCR in hormone-positive locally advanced breast cancer (LABC). METHODS: Ninety hormone-positive LABC patients treated at Marmara University Medical Oncology Clinic, Istanbul, Turkey, between 2009 and 2015 were retrospectively studied...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29131367/influence-of-the-neural-microenvironment-on-prostate-cancer
#4
Christian Coarfa, Diego Florentin, NagiReddy Putluri, Yi Ding, Jason Au, Dandan He, Ahmed Ragheb, Anna Frolov, George Michailidis, MinJae Lee, Dov Kadmon, Brian Miles, Christopher Smith, Michael Ittmann, David Rowley, Arun Sreekumar, Chad J Creighton, Gustavo Ayala
BACKGROUND: Nerves are key factors in prostate cancer (PCa), but the functional role of innervation in prostate cancer is poorly understood. PCa induced neurogenesis and perineural invasion (PNI), are associated with aggressive disease. METHOD: We denervated rodent prostates chemically and physically, before orthotopically implanting cancer cells. We also performed a human neoadjuvant clinical trial using botulinum toxin type A (Botox) and saline in the same patient, before prostatectomy...
November 13, 2017: Prostate
https://www.readbyqxmd.com/read/29128596/comparison-of-the-histologic-risk-assessment-model-between-lower-lip-and-oral-squamous-cell-carcinoma
#5
Mojgan Alaeddini, Shahroo Etemad-Moghadam
INTRODUCTION: The histologic risk assessment (HRA) grading system was proposed as a practical measure to predict clinical outcome and its effectiveness has been shown in several studies. It has been suggested that the HRA model might exhibit differences among various oral subsites. The aim of the present study was to compare this system between squamous cell carcinomas (SCCs) of the lower lip (LL) and oral cavity. MATERIALS AND METHODS: All primary SCCs located in the LL and oral cavity were retrieved and graded using the HRA model...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29126758/maspin-expression-and-subcellular-localization-in-invasive-ductal-carcinoma-of-the-breast-prognostic-significance-and-relation-to-microvessel-density
#6
Duaa S Helal, Dina M El-Guindy
Maspin (Mammary serine protease inhibitor) is a tumor suppressor serine. Its clinical significance and role in breast carcinoma are contradictory and inconclusive. Researches demonstrated that the function of maspin differs according to its subcellular localization. This study was conducted to investigate the expression of maspin in invasive ductal carcinoma (IDC) of the breast with special emphasis on its subcellular localization and to evaluate its prognostic role in relation to clinicopathological parameters and microvessel density (MVD) of the tumor...
November 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29124488/t-helper-1-immune-response-in-metastatic-lymph-nodes-of-pancreatic-ductal-adenocarcinoma-a-marker-for-prolonged-survival
#7
Eran Nizri, Neta Sternbach, Shoshi Bar-David, Amir Ben-Yehuda, Fabian Gerstenhaber, Tali Ofir, Ido Wolf, Gilad Weiner, Guy Lahat, Joseph Klausner
BACKGROUND: Although lymph node (LN) metastases is considered a grave prognostic sign in pancreatic ductal adenocarcinoma (PDAC), patients with positive lymph nodes (PLN) constitute a heterogeneous group. Our purpose was to identify morphological and immune parameters in the primary tumor and in PLN of resected PDAC patients, which could further stratify these patients to different subgroups. METHODS: We retrospectively evaluated histological and immunohistochemical characteristics of 66 patients with PDAC who were operated at our institution...
November 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29122457/radiotherapy-for-tracheal-bronchial-cystic-adenoid-carcinomas
#8
A Levy, A Omeiri, E Fadel, C Le Péchoux
AIMS: Primary tracheal-bronchial adenoid cystic carcinoma (thoracic adenoid cystic carcinoma; TACC) is a rare and aggressive malignant tumour. Radiotherapy results have not been previously individualised in this setting. PATIENTS AND METHODS: Records of 31 patients with TACC (74% tracheal and 26% bronchial) who received radiotherapy between February 1984 and September 2014 were retrospectively analysed. RESULTS: Surgical removal of the primary tumour was carried out for most (71%) patients, and 13/22 (59%) had R1 or R2 (1/22) margins...
November 6, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29122400/aberrant-promoter-methylation-of-the-paqr3-gene-is-associated-with-prostate-cancer
#9
Kowit Lounglaithong, Andrey Bychkov, Pichet Sampatanukul
Methylation markers are promising tools for diagnosis, prognosis and targeted treatment of cancer. In prostate carcinoma, aberrant promoter hypermethylation occurs earlier in the disease course and more consistently than recurrent somatic mutations. PAQR3, a tumor suppressor gene, was recently found to be downregulated in prostate cancer cell lines. We hypothesized that promoter methylation could be responsible for PAQR3 silencing in prostate cancer tissues. We aimed to investigate PAQR3 promoter methylation in prostate cancer by comparing it to benign prostatic hyperplasia (BPH)...
October 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29121459/extramural-perineural-invasion-in-pt3-and-pt4-gastric-carcinomas
#10
Alejandro España-Ferrufino, Leonardo S Lino-Silva, Rosa A Salcedo-Hernández
Background: Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated. Most studies have focused on evaluating the mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis in gastric cancer. We evaluated the prognostic value of ePNI compared with mPNI in gastric cancer in this observational comparative cross-sectional study. Materials and Methods: Seventy-three pT3 and pT4 gastric carcinomas with PNI were evaluated...
November 9, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29113235/dysregulation-of-kras-signaling-in-pancreatic-cancer-is-not-associated-with-kras-mutations-and-outcome
#11
Radmila Lemstrova, Veronika Brynychova, David J Hughes, Viktor Hlavac, Pavel Dvorak, Joanne E Doherty, Helena A Murray, Martin Crockard, Martin Oliverius, Jan Hlavsa, Eva Honsova, Jan Mazanec, Zdenek Kala, Martin Lovecek, Roman Havlik, Jiri Ehrmann, Ondrej Strouhal, Pavel Soucek, Bohuslav Melichar, Beatrice Mohelnikova-Duchonova
Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a poor prognosis, and no targeted therapy is currently available. The aim of the present study was to investigate the prognostic significance of the expression of V-Ki-ras2 Κirsten rat sarcoma viral oncogene homolog (KRAS), downstream signaling pathway genes and the association with clinical characteristics in PDAC patients undergoing radical surgery. Tumors and adjacent non-neoplastic pancreatic tissues were examined in 45 patients with histologically verified PDAC...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29112561/nodal-disease-in-rectal-cancer-patients-with-complete-tumor-response-after-neoadjuvant-chemoradiation-danger-below-calm-waters
#12
Rebeccah B Baucom, Lillias H Maguire, Sandra L Kavalukas, Timothy M Geiger, Molly M Ford, Roberta L Muldoon, M Benjamin Hopkins, Alexander T Hawkins
BACKGROUND: A subset of patients with rectal cancer who undergo neoadjuvant chemoradiation therapy will develop a complete pathologic tumor response. Complete nodal response is not universal in these patients and is difficult to assess clinically. Quantifying the risk of nodal disease would allow for targeted therapy with either radical resection or "watchful waiting." OBJECTIVE: This study aimed to identify risk factors for residual nodal disease in ypT0 rectal adenocarcinoma...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29112018/tumor-budding-and-pdc-grade-are-stage-independent-predictors-of-clinical-outcome-in-mismatch-repair-deficient-colorectal-cancer
#13
Éanna Ryan, Yi Ling Khaw, Ben Creavin, Robert Geraghty, Elizabeth J Ryan, David Gibbons, Ann Hanly, Sean T Martin, P Ronan O'Connell, Desmond C Winter, Kieran Sheahan
Mismatch repair deficient (dMMR) colorectal cancer (CRC) despite its association with poor histologic grade often has improved prognosis compared with MMR proficient CRC. Tumor budding and poorly differentiated clusters (PDCs) may predict metastatic potential of colorectal adenocarcinoma (CRC). In addition, their assessment may be more reproducible than the evaluation of other histopathologic parameters. Therefore, we wished to determine their potential as prognostic indicators in a cohort of dMMR CRC patients relative to histologic grade...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29101572/laparoscopic-modified-mesocolic-excision-with-central-vascular-ligation-in-right-sided-colon-cancer-shows-better-short-and-long-term-outcomes-compared-with-the-open-approach-in-propensity-score-analysis
#14
Jung Kyong Shin, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Ho-Kyung Chun
BACKGROUND: The introduction of complete mesocolic excision (CME) with central vessel ligation (CVL) for right-sided colon cancer has improved oncologic outcomes. However, there is controversy over the oncologic safety of laparoscopic CME with CVL. This study compared short-term and long-term oncologic outcomes between laparoscopic and open modified CME (mCME) with CVL in patients with right-sided colon cancer. METHODS: We enrolled 1239 patients who underwent open mCME with CVL and 1010 patients treated by a laparoscopic approach for right-side colon cancer between 2000 and 2013 and used 1:1 propensity score matching to adjust for potential baseline confounders between two groups...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29100454/peritoneal-recurrence-in-gastric-cancer-following-curative-resection-can-be-predicted-by-postoperative-but-not-preoperative-biomarkers-a-single-institution-study-of-320-cases
#15
Fan Wu, Chunmei Shi, Riping Wu, Zhiqing Huang, Qiang Chen
To determine the risk factors for peritoneal recurrence in gastric cancer patients after curative resection, we included 320 patients with stage I-III primary gastric cancer between January 2008 and June 2012. Data on each patient's surgical and pathological information, preoperative and postoperative tumor markers were collected and analyzed retrospectively. The risk factors for peritoneal recurrence were investigated by univariate and multivariate analysis. In patients with peritoneal recurrence, advanced T or N stage, low differentiation, vascular/lymphatic invasion, perineural invasion, and elevated postoperative CEA/CA19-9 were more common than in patients without peritoneal recurrence...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099504/atypical-fibroxanthoma-and-pleomorphic-dermal-sarcoma-harbor-frequent-notch1-2-and-fat1-mutations-and-similar-dna-copy-number-alteration-profiles
#16
Klaus G Griewank, Thomas Wiesner, Rajmohan Murali, Carina Pischler, Hansgeorg Müller, Christian Koelsche, Inga Möller, Cindy Franklin, Ioana Cosgarea, Antje Sucker, Dirk Schadendorf, Jörg Schaller, Susanne Horn, Thomas Brenn, Thomas Mentzel
Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients. They have differing prognoses and are currently distinguished using histological criteria, such as invasion of deeper tissue structures, necrosis and lymphovascular or perineural invasion. To investigate the as-yet poorly understood genetics of these tumors, 41 atypical fibroxanthomas and 40 pleomorphic dermal sarcomas were subjected to targeted next-generation sequencing approaches as well as DNA copy number analysis by comparative genomic hybridization...
November 3, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29089142/survival-in-patients-with-parotid-gland-carcinoma-results-of-a-multi-center-study
#17
Keigo Honda, Shinzo Tanaka, Shogo Shinohara, Ryo Asato, Hisanobu Tamaki, Toshiki Maetani, Ichiro Tateya, Morimasa Kitamura, Shinji Takebayashi, Kazuyuki Ichimaru, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Masanobu Mizuta, Koichiro Yamada, Koichi Omori
BACKGROUND: Parotid gland carcinoma is a rare malignancy, comprising only 1-4% of head and neck carcinomas; therefore, it is difficult for a single institution to perform meaningful analysis on its clinical characteristics. The aim of this study was to update the clinical knowledge of this rare disease by a multi-center approach. METHODS: The study was conducted by the Kyoto University Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group (Kyoto-HNOG)...
October 24, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29075776/defining-the-prevalence-and-prognostic-value-of-perineural-invasion-and-angiolymphatic-invasion-in-human-papillomavirus-positive-oropharyngeal-carcinoma
#18
William G Albergotti, Hannah L Schwarzbach, Shira Abberbock, Robert L Ferris, Jonas T Johnson, Umamaheswar Duvvuri, Seungwon Kim
Importance: Recently, the American Joint Committee on Cancer (AJCC) updated its staging system for human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). The prognostic significance of perineural invasion (PNI) and angiolymphatic invasion (ALI) within this staging system is unknown. Objective: To examine the prevalence and prognostic significance of PNI and ALI in HPV-positive OPSCC. Design, Setting, and Participants: A retrospective review was performed of all patients with HPV-positive OPSCC treated surgically at the University of Pittsburgh Medical Center from January 1, 1980, through December 31, 2015, with at least 1 year of follow-up or death within 1 year...
October 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29073638/intratumoural-pd-l1-expression-is-associated-with-worse-survival-of-patients-with-epstein-barr-virus-associated-gastric-cancer
#19
An Na Seo, Byung Woog Kang, Oh Kyoung Kwon, Ki Bum Park, Seung Soo Lee, Ho Young Chung, Wansik Yu, Han Ik Bae, Seong Woo Jeon, Hyojeung Kang, Jong Gwang Kim
BACKGROUND: This study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (PD-L1) and programmed cell death protein ligand-2 (PD-L2), in patients with Epstein-Barr virus-associated gastric cancer (EBVaGC). METHODS: After reviewing 1318 consecutive cases of surgically resected or endoscopic submucosal dissected gastric cancers, the expression status of PD-L1 and PD-L2 in 120 patients with EBVaGC identified by EBV-encoded RNA in situ hybridisation was retrospectively analysed using immunohistochemistry (IHC)...
October 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29070814/persistent-elevation-of-postoperative-neutrophil-to-lymphocyte-ratio-a-better-predictor-of-survival-in-gastric-cancer-than-elevated-preoperative-neutrophil-to-lymphocyte-ratio
#20
Kyueng-Whan Min, Mi Jung Kwon, Dong-Hoon Kim, Byoung Kwan Son, Eun-Kyung Kim, Young Ha Oh, Young Chan Wi
Postoperative neutrophil-to-lymphocyte ratio change (NLRc) reflects the dynamic change of balance between host inflammatory response and immune response after treatment. In gastric cancer, an elevated initial NLR (iNLR) is reported to be a prognostic predictor, but the clinical application of the NLRc remains unclear. The NLRc was assessed in 734 patients undergoing total/subtotal gastrectomy and endoscopic submucosal dissection for gastric adenocarcinoma. The iNLR and NLRc were recorded within 10 days of the first diagnosis and 3-6 months after surgery, respectively...
October 25, 2017: Scientific Reports
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