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Perineural invasion Or PNI

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https://www.readbyqxmd.com/read/28237042/expression-of-ngf-gdnf-and-mmp-9-in-prostate-carcinoma
#1
Sirin Baspinar, Sema Bircan, Metin Ciris, Nermin Karahan, Kemal Kursat Bozkurt
The aim of the present study was to investigate the immunohistochemical expression of NGF, GDNF and MMP-9 in benign prostatic hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN) and prostate cancer (PC), and to analyse their association with the clinicopathological parameters in PC cases. Immunohistochemistry was performed on the tissue microarray (TMA) sections of 30 BPH, 40 HGPIN and 121 primary PC tissues. There was a significant difference regarding the expression of NGF and GDNF between PC and HGPIN (p<0...
February 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28225961/analysis-of-the-histomorphologic-profile-of-invasive-cutaneous-squamous-cell-carcinoma-from-2002-to-2011-in-a-pathology-laboratory-in-the-region-of-campos-gerais-brazil
#2
Fernanda Magri de Souza, Eloina Do Rocio Valenga Baroni, Mário Rodrigues Montemór
Squamous cell carcinoma is the second most common type of malignant skin cancer. It is also quite aggressive. The increasing incidence of the disease can be altered given its connection with sun exposure. The aim of this study was to establish the clinical and histomorphological profile of squamous cell carcinoma in the region of Campos Gerais, State of Paraná, Brazil and analyze and compare the features of the disease found in the literature. We conducted a cross-sectional descriptive study in a pathology laboratory with selected invasive cutaneous squamous cell carcinoma reports issued after excisional biopsy from January 2002 to December 2011...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28223016/lymph-node-involvement-predicts-poor-prognosis-in-primary-tongue-adenoid-cystic-carcinoma-a-preliminary-study-of-54-cases
#3
Nannan Han, Huishan Ong, Zhihui Liu, Min Ruan, Wenjun Yang, Chenping Zhang
PURPOSE: Primary tongue adenoid cystic carcinoma (ACC) is extremely rare. The relationship between the patient's prognosis and the tumor's clinicopathological characteristics is uncertain. The aim of this study was to identify the prognostic factors and analyze the overall outcomes for patients with tongue ACC. PATIENTS AND METHODS: A retrospective analysis of the medical records of patients diagnosed with primary tongue ACC between 1998 and 2008 was conducted. The study comprised 54 patients, with a median age of 53...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28215306/neurotrophin-receptors-and-perineural-invasion-analyses-in-select-lineage-unrelated-cutaneous-malignancies-with-a-propensity-for-perineural-invasion
#4
N F Frydenlund, M Mahalingam
In this chapter, we parse the literature on neurotrophins that have been implicated in the pathogenesis of perineural invasion (PNI) in select lineage-unrelated malignancies. We also detail evidence linking neurotrophins and their receptors (TrkA, RET, p75NGFR, and NCAM) to the pathogenesis of PNI in desmoplastic melanoma and cutaneous squamous cell carcinoma-both malignancies with an established propensity for PNI. Lastly, the clinical potential of neurotrophins as receptors for targeted therapies is explored...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28209950/-clinico-pathological-factors-and-prognosis-scale-for-portal-cholangiocarcinoma
#5
Yu O Zharikov, Yu A Kovalenko, A A Olifir, D V Kalinin, A V Czhao
INTRODUCTION: The objective of this study was to derive a prognostic scale to predict overall survival (OS) after a curative resection of perihilar cholangiocarcinoma (PHC). MATERIAL AND METHODS: The data of 55 patients with portal cholangiocarcinoma were analysed. Patients were treated at the A.V. Vishnevsky Institute of Surgery from 2011 to 2015. Surgical treatment after biliary decompression was performed in 37 (67.3%) patients. In the long-term period we observed 36 (97...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28208932/spontaneous-rupture-of-the-main-pancreatic-duct-synchronous-with-a-multi-focal-microscopic-pancreatic-adenocarcinoma-a-case-report
#6
Shirly Shohat, Katerina Shulman, Boris Kessel, Oren Gal, Abdel Rauf Zeina
Pancreatic cancer is one of the most lethal types of malignant tumours, commonly diagnosed at an advanced stage. The only curative treatment for this fatal disease is surgery and early diagnosis is the key to a better outcome and prognosis. In this case report we present a 57-year-old woman presenting to the emergency room with abdominal pain and weight loss. Computer Tomography (CT) imaging showed a rupture of the main pancreatic duct and a peri-pancreatic fluid collection with no evidence of a pancreatic mass...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28206935/national-disparities-in-surgical-approach-to-t1-rectal-cancer-and-impact-on-outcomes
#7
Emmanuel Gabriel, Pragatheeshwar Thirunavukarasu, Eisar Al-Sukhni, Kristopher Attwood, Steven J Nurkin
This study investigated disparities between patients who had local excision versus radical resection for T1 rectal cancer. A retrospective analysis was performed using the National Cancer Data Base, 2004 to 2011. Inclusion criteria consisted of patients with T1, N0 rectal adenocarcinoma that were <3 cm, well or moderately differentiated without perineural invasion. Patients were stratified based on local excision and radical surgery. The primary outcome was overall survival (OS). Secondary outcomes included 30-day mortality, unplanned readmission rates, and postoperative length of stay...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28196410/mesothelin-expression-in-gastric-adenocarcinoma-and-its-relation-to-clinical-outcomes
#8
Song-Hee Han, Mee Joo, Hanseong Kim, Sunhee Chang
Background: Although surgical resection with chemotherapy is considered effective for patients with advanced gastric cancer, it remains the third leading cause of cancer-related death in South Korea. Several studies have reported that mesothelial markers including mesothelin, calretinin, and Wilms tumor protein 1 (WT1) were positive in variable carcinomas, associated with prognosis, and were evaluated as potential markers for targeted therapy. The aim of this study was to assess the immunohistochemical expression of mesothelial markers (mesothelin, calretinin, and WT1) in gastric adenocarcinoma and their relations to clinocopathological features and prognosis...
February 15, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28195087/perineural-invasion-is-a-valuable-prognostic-factor-in-advanced-stage-and-or-node-cervical-cancer
#9
Cigdem Vural, Busra Yaprak Bayrak, Bahar Muezzınoglu, Izzet Yucesoy
BACKGROUND: Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance cervical cancer remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes in clinically localized surgically treated cervical cancers. MATERIALS AND METHODS: We reviewed clinical records and pathology slides of 111 patients with cervical cancer treated with surgery at a single academic center...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28188750/kras-and-pik3ca-mutations-in-colorectal-adenocarcinomas-correlate-with-aggressive-histological-features-and-behavior
#10
Sejin Jang, Mineui Hong, Mi Kyung Shin, Byung Chun Kim, Hyung-Sik Shin, Eunsil Yu, Seung-Mo Hong, Jihun Kim, Sung Min Chun, Tae-Im Kim, Kyung-Chan Choi, Young Woong Ko, Jeong Won Kim
Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition (EMT) and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli (LVE), perineural invasion (PNI), and an infiltrative growth pattern. Mutations in the genes of the Ras-MAPK and PI3K pathways are associated with EMT and an aggressive CRC phenotype and have been used in patient stratification for anti-EGF receptor therapies; however, the impact of these mutations on CRC morphology and behavior remains unclear...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28181952/perineural-pseudoinvasion-an-unusual-phenomenon-in-nonmalignancies
#11
REVIEW
Mansour Moghimi, Fatemeh Joukar, Amin Salehi-Abargouei, Mohammad-Reza Mozayan, Amir Aryanfar
Perineural invasion (PNI) is characterized as tumoral or nontumoral cells invading in or around the nerves. The neural invasion is considered as a histopathologic characteristic for malignancy and is considered a mechanism for its spread. Both of these patterns usually portend a poor prognosis and very often are markers to prompt additional treatment. There are also some nonmalignancies representing PNI, including benign neoplasms, mimicking lesions, and disorders, such as chronic pancreatitis and endometriosis...
March 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28180041/update-on-surgical-outcomes-of-lateral-temporal-bone-resection-for-ear-and-temporal-bone-malignancies
#12
Sumi Sinha, Matthew M Dedmon, Matthew R Naunheim, Jennifer C Fuller, Stacey T Gray, Derrick T Lin
Objectives Review outcomes of lateral temporal bone resections for ear and temporal bone malignancy. Design, Setting, and Participants Retrospective review of all lateral temporal bone resections performed from 2008 to 2015 at a single tertiary care center. Main Outcome Measures Patient demographics, perioperative variables, overall survival, disease-free survival (DFS), and comparison of Kaplan-Meier curves. Results Overall, 56 patients were identified with a mean follow-up period of 2.3 ± 1.8 years...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28178650/serpinb3-upregulates-the-cyclooxygenase-2-%C3%AE-catenin-positive-loop-in-colorectal-cancer
#13
Liliana Terrin, Marco Agostini, Mariagrazia Ruvoletto, Andrea Martini, Salvatore Pucciarelli, Chiara Bedin, Donato Nitti, Patrizia Pontisso
Colorectal cancer is characterized by aberrant Cyclooxigenase-2 (COX-2) and β-Catenin pathways. Recently, the protease inhibitor SerpinB3 has been described overexpressed in more advanced stages of this tumor. Aim of the study was to explore the possible relationship between these molecules in this setting. We evaluated colorectal cancer specimens from 105 patients and a positive correlation between SerpinB3, COX-2 and β-Catenin expression was observed, with higher levels in tumor than in adjacent tissue...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28171708/a-multi-institutional-comparison-of-outcomes-of-immunosuppressed-and-immunocompetent-patients-treated-with-surgery-and-radiation-therapy-for-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#14
Bindu V Manyam, Adam A Garsa, Rei-I Chin, Chandana A Reddy, Brian Gastman, Wade Thorstad, Sue S Yom, Brian Nussenbaum, Steven J Wang, Allison T Vidimos, Shlomo A Koyfman
BACKGROUND: Patients who are chronically immunosuppressed have higher rates of cutaneous squamous cell carcinoma of the head and neck (cSCC-HN). This is the largest multi-institutional study to date investigating the effect of immune status on disease outcomes in patients with cSCC-HN who underwent surgery and received postoperative radiation therapy (RT). METHODS: Patients from 3 institutions who underwent surgery and also received postoperative RT for primary or recurrent, stage I through IV cSCC-HN between 1995 and 2015 were included in this institutional review board-approved study...
February 7, 2017: Cancer
https://www.readbyqxmd.com/read/28169208/evaluation-of-prognostic-factors-and-implication-of-lymph-node-dissection-in-intrahepatic-cholangiocarcinoma-10-year-experience-at-a-tertiary-referral-center
#15
Miao-Erh Chang, Hao-Jan Lei, Ming-Huang Chen, Yi-Chen Yeh, Chung-Pin Li, Yi-Ping Hung, Cheng-Yuan Hsia, Chieu-An Liu, Gar-Yang Chau, Yee Chao
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver malignancy, and surgical resection remains the only potentially curative treatment. However, the existing literature indicates that those prognostic factors associated with outcome after surgery remain poorly defined. METHODS: Data were retrospectively collected from 103 patients with ICC who underwent surgical resection between 2005 and 2014. The patients were divided into two groups: one with (D1) and one without (D0) lymph node dissection of hepatic hilum according to the surgery performed...
February 3, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28164587/high-expression-of-orai1-enhances-cell-proliferation-and-is-associated-with-poor-prognosis-in-human-colorectal-cancer
#16
Lin Gui, Zhenjun Wang, Jiagang Han, Huachong Ma, Zhulin Li
BACKGROUND: Store-operated Ca2+ entry (SOCE) is the predominant Ca2+ influx mechanism in non-excitable cells and regulates a variety of cellular functions. As the essential channel pore-forming protein of SOCE, Orai1 has recently been implicated in carcinogenesis and tumor progression in multiple malignancies. However, the role of Orai1 in colorectal cancer (CRC) has not been investigated. METHODS: The expression of Orai1 in 21 CRC specimens was examined by immunohistochemistry (IHC) staining, Western blot, and qRT-PCR...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162923/interferon-based-chemoradiation-followed-by-gemcitabine-for-resected-pancreatic-adenocarcinoma-long-term-follow-up
#17
Kerri A Ohman, Jingxia Liu, David C Linehan, Marcus C Tan, Benjamin R Tan, Ryan C Fields, Steven M Strasberg, William G Hawkins
: To report long-term follow up of a phase II, single-arm trial of resectable pancreatic ductal adenocarcinoma (PDAC) treated with adjuvant interferon-based chemoradiation followed by gemcitabine to determine survival, recurrence, and complications. METHODS: From 2002 to 2005, 53 patients with PDAC underwent pancreaticoduodenectomy and received adjuvant interferon-based chemoradiation consisting of external-beam irradiation and simultaneous 3-drug chemotherapy of continuous daily 5-fluorouracil infusion, weekly intravenous bolus cisplatin, and subcutaneous interferon-α, followed by two months of weekly intravenous gemcitabine...
February 2, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28153567/elevated-tarp-promotes-proliferation-and-metastasis-of-salivary-adenoid-cystic-carcinoma
#18
Haitang Yue, Yu Cai, Yaling Song, Liuyan Meng, Xinming Chen, Mingwei Wang, Zhuan Bian, Rong Wang
OBJECTIVE: This study aims to analyze the expression of T-cell receptor γ chain alternate reading frame protein (TARP) in salivary adenoid cystic carcinoma (SACC) and its distant metastases and to investigate its influences on the development and progression of SACC. STUDY DESIGN: TARP expression was analyzed in 50 primary SACCs, 13 specimens of metastatic adenoid cystic carcinoma of salivary gland origin, and 20 noncancerous tissues around SACC via immunohistochemistry...
December 7, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28138968/recurrence-after-resection-with-curative-intent-for-distal-cholangiocarcinoma
#19
K Komaya, T Ebata, K Shirai, S Ohira, N Morofuji, A Akutagawa, R Yamaguchi, M Nagino
BACKGROUND: Few studies have been conducted on patterns of recurrence after resection for distal cholangiocarcinoma (DCC). The aim of this study was to investigate the incidence and pattern of recurrence after resection of DCC, and to evaluate prognostic factors for time to recurrence and recurrence-free survival (RFS). METHODS: Patients who underwent pancreatoduodenectomy with curative intent for DCC between 2001 and 2010 at one of 30 hospitals in Japan were reviewed retrospectively, with special attention to recurrence patterns...
January 31, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28137555/surveillance-and-comparison-of-surgical-prognosis-for-asymptomatic-and-symptomatic-non-functioning-pancreatic-neuroendocrine-tumors
#20
Wenhao Ge, Dongkai Zhou, Shaoyan Xu, Weilin Wang, Shusen Zheng
BACKGROUND: The treatment of non-functioning pancreatic neuroendocrine tumors (NF-PNETs) still remains controversial. It is uncertain whether asymptomatic patients have better prognosis than symptomatic patients and whether surgery is necessary for asymptomatic patients. METHODS: Patients with NF-PNETs who were managed surgically or by surveillance between June 2007 and December 2013 were retrospectively studied. The choice of surgery or surveillance was based entirely on the patient's desire...
January 27, 2017: International Journal of Surgery
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