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Perineural invasion Or PNI

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https://www.readbyqxmd.com/read/29779859/-rapidly-growing-squamous-cell-carcinoma-after-ingenol-mebutate-treatment
#1
M Ehret, C Velter, M Tebacher, C Bruant-Rodier, B Cribier
INTRODUCTION: Ingenol mebutate is an actinic keratosis treatment, which has a dual action mechanism. It allows a rapid cellular death and a severe inflammation. OBSERVATION: We report the case of a 75 years old patient with a rapidly growing tumor 5 weeks after application of ingenol mebutate on typical actinic keratosis. Histological analysis after surgical excision showed an invasive squamous cell carcinoma (SCC); with aggressiveness signs: perineural infiltration and vascular permeation...
May 17, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29779285/-advances-in-the-molecular-mechanisms-of-perineural-invasion-in-salivary-adenoid-cystic-carcinoma
#2
Mei Zhang, Xin-Hua Liang, Ya-Ling Tang
Salivary adenoid cystic carcinoma is a very common malignant neoplasm in the salivary glands. One of the most important features of salivary cystic carcinoma is perineural invasion, which renders its complete removal is very difficult through clinical surgery. Consequently, tumor recurrence occurs easily after clinical surgery. Therefore, the molecular mechanisms of perineural invasion in salivary adenoid cystic carcinoma are necessary to explore. These mechanisms are reviewed in this paper.
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29777295/laser-debulking-or-tracheotomy-in-airway-management-prior-to-total-laryngectomy-for-t4a-laryngeal-cancer
#3
Djamil Semdaie, Fabienne Haroun, Odile Casiraghi, François Bidault, Stéphane Temam, François Janot, Philippe Gorphe
PURPOSE: Retrospective studies have shown that tracheotomy prior to total laryngectomy (TL) is associated with decreased survival. We sought to investigate whether this is due to higher local invasiveness associated with obstructive disease or whether it is the result of tracheotomy itself. METHODS: We reviewed patients with a T4a (AJCC 7th edition) laryngeal squamous-cell carcinoma treated with a primary TL followed by adjuvant radiotherapy between 2001 and 2013...
May 18, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29763716/prognostic-factors-in-primary-anorectal-melanoma-a-clinicopathologic-study-of-60-cases-in-china
#4
Min Ren, Yawen Lu, Jiaojie Lv, Xuxia Shen, Jincheng Kong, Bo Dai, Yunyi Kong
To investigate the clinicopathologic features and prognostic factors of primary anorectal melanoma, we described the clinical presentations, histopathology, and prognosis of 60 cases in China. Patients' age ranged from 17 to 86years with a female-to-male ratio of 2.33:1. The prevalent anatomic site of tumor was anorectum. The mean tumor thickness was 11.5mm and mean tumor size was 2.9cm. Abdominoperineal resection was performed on 38 (63.3%) patients, while wide local excision on 22 (36.7%) patients. Thirty-three (55...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29759308/the-value-of-adjuvant-radiotherapy-in-cutaneous-squamous-cell-carcinoma-a-review
#5
J Cañueto, A Jaka, A Toll
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in humans and its incidence is rising. Although surgery is the treatment of choice for cSCC, postoperative adjuvant radiotherapy has an important role in local and locorregional disease control. In this review, we analyze the value of postoperative radiotherapy therapy in the management of high-risk cSCC (in particular, cases with perineural invasion), cSCC with positive surgical margins, and locally advanced cSCC (with parotid gland and/or lymph node metástasis)...
May 11, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29755671/should-reporting-of-peri-neural-invasion-and-extra-prostatic-extension-be-mandatory-in-prostate-cancer-biopsies-correlation-with-outcome-in-biopsy-cases-treated-conservatively
#6
Amar S Ahmad, Vishnu Parameshwaran, Luis Beltran, Gabrielle Fisher, Bernard V North, David Greenberg, Geraldine Soosay, Henrik Møller, Peter Scardino, Jack Cuzick, Daniel M Berney
The identification of perineural invasion (PNI) and extraprostatic extension (ECE) in prostate cancer (PC) biopsies is time consuming and can be difficult. Although this is required information in many datasets, there is little evidence on their effect on outcome in patients treated conservatively. Cases of PC were identified from three cancer registries in the UK from men with clinically localized prostate cancer diagnosed by needle biopsy from 1990-2003. The endpoint was prostate cancer death (DOD). Patients treated radically within 6 months, those with objective evidence of metastases or who had prior hormone therapy were excluded...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755594/perineural-invasion-in-early-stage-cervical-cancer-and-its-relevance-following-surgery
#7
Yi Zhu, Guonan Zhang, Yan Yang, Ling Cui, Shijun Jia, Yu Shi, Shuiqin Song, Shiqiang Xu
Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that has attracted attention as a novel prognostic factor for cancer. The present study aimed to investigate the prognostic value of PNI in patients with early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2-IIA). A total of 210 patients who underwent radical hysterectomy and pelvic lymphadenectomy between 2007 and 2012 were included in the current study, of whom 8.57% (18/210) exhibited PNI...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29745479/predictors-of-one-and-two-year-mortality-in-patients-with-rectal-cancer
#8
José M Quintana, Nerea González, Santiago Lázaro, Marisa Baré, Nerea Fernandez de Larrea, Maximino Redondo, Eduardo Briones, Antonio Escobar, Cristina Sarasqueta, Susana García-Gutierrez, Ane Antón-Ladislao
AIM: Tools are needed to aid in the assessment of prognosis of patients with rectal cancer regarding the risk of medium-term mortality. The aim of this study was to develop and validate clinical prediction rules for 1- and 2-year mortality in patients undergoing surgery for rectal cancer. METHOD: A prospective cohort study of patients diagnosed with rectal cancer who underwent surgery was carried out. The main outcomes were mortality at 1 and 2 years after surgery...
May 10, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29742559/pd-l1-expression-is-increased-in-metastasizing-squamous-cell-carcinomas-and-their-metastases
#9
Irene García-Díez, Eugenia Hernández-Ruiz, Evelyn Andrades, Javier Gimeno, Carla Ferrándiz-Pulido, Mireia Yébenes, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz, Agustí Toll
Programmed cell death ligand 1 (PD-L1) expression by tumor cells plays an important role in the inhibition of T cell-mediated immune response in cancer. PD-L1 expression by tumor cells has been linked to poor prognosis in a wide variety of cancers. However, PD-L1 expression in cutaneous squamous cell carcinoma (cSCC) has been scarcely studied, and its role as a prognosis biomarker remains controversial. The association of PD-L1 expression and the metastatic risk in a series of cSCC was assessed. PD-L1 and CD8 immunostainings of full excision sections of 99 primary tumors and 24 lymphatic metastases were semiquantitatively evaluated...
May 3, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29741773/phase-2-trial-of-neoadjuvant-chemotherapy-and-transoral-endoscopic-surgery-with-risk-adapted-adjuvant-therapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#10
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29736668/immunohistochemical-predictors-for-intestinal-and-pancreatobiliary-types-of-adenocarcinoma-of-the-ampulla-of-vater
#11
João Paulo Lemos da Silveira Santos, Carla Jorge Machado, Eduardo Paulino Junior, João Bernardo Sancio Rocha Rodrigues, Paula Teixeira Vidigal, Vivian Resende
OBJECTIVES: To investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival. METHODS: Immunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29733315/an-in-vivo-murine-sciatic-nerve-model-of-perineural-invasion
#12
Sylvie Deborde, Yasong Yu, Andrea Marcadis, Chun-Hao Chen, Ning Fan, Richard L Bakst, Richard J Wong
Cancer cells invade nerves through a process termed perineural invasion (PNI), in which cancer cells proliferate and migrate in the nerve microenvironment. This type of invasion is exhibited by a variety of cancer types, and very frequently is found in pancreatic cancer. The microscopic size of nerve fibers within mouse pancreas renders the study of PNI difficult in orthotopic murine models. Here, we describe a heterotopic in vivo model of PNI, where we inject syngeneic pancreatic cancer cell line Panc02-H7 into the murine sciatic nerve...
April 23, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29731576/quantitative-assessment-of-tumor-associated-tissue-eosinophilia-and-mast-cells-in-tumor-proper-and-lymph-nodes-of-oral-squamous-cell-carcinoma
#13
Shivani Jain, Rashmi Gs Phulari, Rajendrasinh Rathore, Arpan K Shah, Sankalp Sancheti
Background: Oral squamous cell carcinoma (OSCC) is the most common cancer of oral cavity. Tumor stage, thickness, lymph node metastasis (LNM), extranodal spread, perineural invasion, tumor differentiation, mutations, human papillomavirus infection, and tumor microenvironment are independent prognostic indicators of OSCC. However, clinically, among all factors, LNM is considered an important prognostic factor in OSCC as it not only determines the stage of disease but also the strongest independent factor which predicts recurrence of disease...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29725538/appendiceal-carcinoma-associated-with-microsatellite-instability
#14
Angélica Morales-Miranda, Ismael Domínguez Rosado, Carlos Chan Núñez, Fredy Chable Montero
Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique biological behavior. The present study presents a case of appendiceal carcinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-old male patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, following an acute attack, he was subjected to laparoscopic appendectomy...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29725477/potential-biological-functions-of-microvesicles-derived-from-adenoid-cystic-carcinoma
#15
Zhuoyuan Zhang, Chaoran Yan, Bo Li, Longjiang Li
Microvesicles (MVs) are secreted by multiple types of tumor cell and are involved in tumor progression and metastasis. The aim of the present study was to explore the effects of MVs derived from salivary adenoid cystic carcinoma (SACC) and to investigate their potential involvement in the pathogenesis of perineural invasion of SACC. MVs were isolated from ACCs cells, and differential gene expression profiles of these MVs were compared with their donor cells to speculate on their biological functions. Several candidate genes were validated using reverse transcription-quantitative polymerase chain reaction analysis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29725255/amacr-overexpression-acts-as-a-negative-prognostic-factor-in-oral-squamous-cell-carcinoma
#16
Hong-Lin He, Ying-En Lee, Min-Te Chang, Yow-Ling Shiue, Shih-Lun Chang, Tzu-Ju Chen, Chang-Ta Chiu
Background : Alpha-methylacyl-CoA racemase (AMACR) is a key enzyme responsible for the metabolism of branched-chain fatty acids. It has been found to be an important prognostic factor in numerous types of cancers. This study was aimed to investigate the expression of AMACR and its prognostic significance in patients with oral squamous cell carcinoma (SCC). Methods : Analysis of publicly available microarray data of oral SCC revealed that AMACR was significantly upregulated in tumor tissue compared with normal mucosa...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29720406/contemporary-prostate-biopsy-reporting-insights-from-a-survey-of-clinicians-use-of-pathology-data
#17
Murali Varma, Krishna Narahari, Malcolm Mason, Jon D Oxley, Daniel M Berney
AIM: To determine how clinicians use data in contemporary prostate biopsy reports. METHODS: A survey was circulated to members of the British Association of Urological Surgeons and the British Uro-oncology Group. RESULTS: Responses were received from 114 respondents (88 urologists, 26 oncologists). Ninety-seven (94%) use the number of positive cores from each side and 43 (42%) use the % number of positive cores. When determining the number and percentage of positive cores, 72 (71%) would not differentiate between targeted and non-targeted samples...
May 2, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29715132/synchronous-pancreatic-ductal-adenocarcinoma-and-hepatocellular-carcinoma-report-of-a-case-and-review-of-the-literature
#18
Jenny Z Lai, Yihua Zhou, Dengfeng Cao
Two or more histologically distinct malignancies diagnosed during the same hospital admission are uncommon, but they do exist. Cases with synchronous primary pancreatic ductal adenocarcinoma and hepatocellular carcinoma are rarely seen. This is a case report of a 56 years old Caucasian female with the chief complaint of jaundice over a duration of 10 days. CT imaging findings revealed a 3.5 cm ill-defined pancreatic head mass and a 1.5 cm liver mass in the segment 5. EUS-FNA cytology showed pancreatic head ductal adenocarcinoma (PDAC)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29714816/sentinel-lymph-node-metastasis-in-primary-cutaneous-basosquamous-carcinoma-a-cross-sectional-study
#19
Despoina D Kakagia, Polyxeni Zapandioti, Grigoris Trypsiannis, Alexandra N Grekou, Dimosthenis Tsoutsos
BACKGROUND AND OBJECTIVES: Basosquamous carcinoma (BSC) is a rare, biologically aggressive tumor. This cross-sectional study aims to define risk factors for subclinical nodal metastasis in primary BSC, and identify the patients who would benefit from routine sentinel node biopsy (SLNB) as part of the initial management. METHODS: A total of 142 patients, with histologically proven BSC without palpable lymph nodes, underwent SLNB after the initial excision. Clinicopathological features and demographics were analyzed between the patients with detected micrometastasis (SLNM) and those with negative SLN...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29713823/higher-visceral-fat-area-subcutaneous-fat-area-ratio-measured-by-computed-tomography-is-associated-with-recurrence-and-poor-survival-in-patients-with-mid-and-low-rectal-cancers
#20
Kang Hong Lee, Bo-Kyeong Kang, Byung Kyu Ahn
PURPOSE: Obesity is thought to influence postoperative complications and recurrence of mid and low rectal cancer (MLRC) because of intraoperative technical difficulties. However, few reports have described the relationship between obesity indices and the clinical outcomes of MLRC. This study aimed to investigate the association between visceral obesity on computed tomography (CT) and oncolofical outcomes after surgery for MLRC and identify the obesity index that most accurately reflects clinical outcomes...
April 30, 2018: International Journal of Colorectal Disease
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