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https://www.readbyqxmd.com/read/29749324/changes-in-acute-viral-hepatitis-epidemiology-in-the-turkish-adult-population-a-multicenter-study
#1
Zehra Karacaer, Selma Tosun, Ayşe Batırel, Suzan Şahin, İrem Altaş, Serhat Uysal, Serpil Erol, Nurgül Ceran, Ayşe Albayrak, İlknur Esen Yıldız, Uğur Kostakoğlu, Fatma Kaçar, Nuretdin Kuzhan, Ayten Kadanalı, Gül Karagöz, Ercan Yenilmez, Derya Bayırlı Turan, Arzu Altunçekiç Yıldırım, Funda Koçak, Rıza Aytaç Çetinkaya, Mehmet Parlak, Özlem Aydın, Pınar Ergen, Gül Durmuş, Türkkan Öztürk Kaygusuz, Özgur Dağlı, Canan Demir, Fatma Yılmaz Karadağ
BACKGROUND/AIMS: The present study aimed to determine the changes in the epidemiology of hepatitis in recent years in an adult Turkish population. MATERIALS AND METHODS: Overall, 852 patients with acute viral hepatitis from 17 centers were included in this study. Their sociodemographic characteristics, clinical courses, treatments, and laboratory findings were retrospectively analyzed. RESULTS: The most commonly found microorganisms were the hepatitis B virus (55...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29684430/development-of-an-rna-based-kit-for-easy-generation-of-tcr-engineered-lymphocytes-to-control-t-cell-assay-performance
#2
Nicole Bidmon, Sonja Kind, Marij J P Welters, Deborah Joseph-Pietras, Karoline Laske, Dominik Maurer, Sine Reker Hadrup, Gerty Schreibelt, Richard Rae, Ugur Sahin, Cécile Gouttefangeas, Cedrik M Britten, Sjoerd H van der Burg
Cell-based assays to monitor antigen-specific T-cell responses are characterized by their high complexity and should be conducted under controlled conditions to lower multiple possible sources of assay variation. However, the lack of standard reagents makes it difficult to directly compare results generated in one lab over time and across institutions. Therefore TCR-engineered reference samples (TERS) that contain a defined number of antigen-specific T cells and continuously deliver stable results are urgently needed...
April 20, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29670778/multiple-arterial-thrombosis-related-with-cantharidin-ingestion
#3
Zehra Narli Ozdemir, Ugur Sahin, Sinem Civriz Bozdag, Osman Ilhan
Inherited and/or acquired thrombophilic defects can result in venous or arterial thrombosis. This case report describes arterial thrombotic episodes triggered by the ingestion of an aphrodisiac remedy containing cantharidin in a 46-year-old female patient later discovered to be heterozygous for prothrombin G20210A mutation and seropositive for anti- β 2 glycoprotein-I (anti- β 2-GPI) antibodies of IgA isotype.
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29625248/how-to-transfer-a-quantitative-molecular-diagnostic-test-to-multiple-qpcr-platforms
#4
Claudia Gürtler, Mark Laible, Wolfgang Schwabe, Heike Steinhäuser, Xingmin Li, Shujin Liu, Kornelia Schlombs, Ugur Sahin
Quantitative gene expression assays are increasingly used for diagnosis and research, but are often restricted to specific instrumentation. We propose a robust technical and statistical framework that enables transferring of established RT-qPCR assays across qPCR platforms without compromising analytical and clinical validity. The feasibility of our approach on MammaTyper®, an in vitro diagnostic assay which quantifies breast cancer biomarkers and dichotomizes results according to cut-off points, was tested...
April 3, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29587858/hla-and-proteasome-expression-body-map
#5
Sebastian Boegel, Martin Löwer, Thomas Bukur, Patrick Sorn, John C Castle, Ugur Sahin
BACKGROUND: The presentation of HLA peptide complexes to T cells is a highly regulated and tissue specific process involving multiple transcriptionally controlled cellular components. The extensive polymorphism of HLA genes and the complex composition of the proteasome make it difficult to map their expression profiles across tissues. METHODS: Here we applied a tailored gene quantification pipeline to 4323 publicly available RNA-Seq datasets representing 55 normal tissues and cell types to examine expression profiles of (classical and non-classical) HLA class I, class II and proteasomal genes...
March 27, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29567706/personalized-vaccines-for-cancer-immunotherapy
#6
REVIEW
Ugur Sahin, Özlem Türeci
Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can generate cancer-specific neoepitopes that are recognized by autologous T cells as foreign and constitute ideal cancer vaccine targets. Every tumor has its own unique composition of mutations, with only a small fraction shared between patients. Technological advances in genomics, data science, and cancer immunotherapy now enable the rapid mapping of the mutations within a genome, rational selection of vaccine targets, and on-demand production of a therapy customized to a patient's individual tumor...
March 23, 2018: Science
https://www.readbyqxmd.com/read/29559300/allogeneic-stem-cell-transplantation-for-relapsed-primary-central-nervous-system-lymphoma-is-it-feasible
#7
Erden Atilla, Ugur Sahin, Pinar Ataca Atilla, Mustafa Merter, Elif Ozyurek, Koray Ceyhan, Sinem Civriz Bozdag
Primary central nervous system lymphoma (PCNSL), has an aggressive course and in untreated patients median survival is limited to three months. For relapsed PCNSL, the treatment options are few and results are usually unsatisfactory. Allogeneic Hematopoietic Stem Cell Transplantation (allo-HCT) has been widely used for treatment of relapsed/refractory NHL patients. However there are limited data whether graft versus lymphoma effect can work in PCNSL patients. Here, we present a relapsed refractory PCNSL case treated by allo-HCT...
March 16, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29549412/donor-recipient-killer-immunoglobulin-like-receptor-kir-genotype-matching-has-a-protective-effect-on-chronic-graft-versus-host-disease-and-relapse-incidence-following-hla-identical-sibling-hematopoietic-stem-cell-transplantation
#8
COMPARATIVE STUDY
Ugur Sahin, Klara Dalva, Funda Gungor, Celalettin Ustun, Meral Beksac
Impact of donor-recipient killer immunoglobulin-like receptor (KIR) gene-gene matching on transplant outcomes is still inconclusive. Recent data suggest that killer cell immunoglobulin-like receptor (KIR) regulated natural killer cell (NK cell) activity may contribute to graft versus leukemia (GvL) effects and graft versus host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This case-control study aims to evaluate the effects of both aKIR and iKIR donor-recipient genotype matching on the outcomes of T cell replete HLA-identical sibling allo-HSCTs in a homogenous young patient population with myeloid leukemias...
June 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29512624/association-between-reverse-electrical-remodeling-and-cardiac-fibrosis-markers-in-patients-with-cardiac-resynchronization-therapy
#9
Hamza Sunman, Uğur Canpolat, Hikmet Yorgun, Adem Özkan, Muhammet Ulvi Yalçın, Tülin Bayrak, Levent Şahiner, Ergün Barış Kaya, Asuman Özkara, Kudret Aytemir, Ali Oto
OBJECTIVE: Cardiac resynchronization therapy (CRT) induces structural and electrical reverse remodeling of the failing heart. However, the association between native QRS narrowing and cardiac fibrosis markers has not been investigated in patients with an implanted CRT device. METHODS: A total of 41 symptomatic patients diagnosed with systolic heart failure who underwent CRT implantation were included in this study. Electrocardiogram findings and cardiac fibrosis marker levels [galectin-3, growth-differentiation factor-15 (GDF-15) and procollagen III N-terminal propeptide (P3TD)] were collected before and 12 months after initiation of biventricular pacing...
March 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29492127/endotracheal-intubation-for-penetrating-neck-trauma
#10
Sevtap Hekimoglu Sahin, Beyhan Karamanlioglu, Mehmet Turan Ina, Huseyin Ugur, Tolgay Akıncı, Hakan Tagrikulu, Banu Tutunculer
Tracheal intubation is performed as part of daily routine in the operating room, rarely with complications. However, management of airway for cases such as a penetrating neck trauma case might constitute exceptions, in which cases the stabilization of the neck to prevent any further neural damage is a significant source of concern for the anesthesiologist. Generally, intubation techniques for penetrating neck trauma were planned according to the initial position of patients. To our knowledge, this is the first case report of alterated the position of the patient during the anesthesia induction for direct laryngoscopy...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29482642/prognostic-impact-of-cd4-positive-t-cell-subsets-in-early-breast-cancer-a-study-based-on-the-finher-trial-patient-population
#11
Marcus Schmidt, Veronika Weyer-Elberich, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Aslihan Gerhold-Ay, Antje Lebrecht, Marco J Battista, Annette Hasenburg, Ugur Sahin, Konstantine T Kalogeras, Pirkko-Liisa Kellokumpu-Lehtinen, George Fountzilas, Ralph M Wirtz, Heikki Joensuu
BACKGROUND: The clinical importance of tumor-infiltrating cluster of differentiation 4 (CD4) T cells is incompletely understood in early breast cancer. We investigated the clinical significance of CD4, forkhead box P3 (FOXP3), and B cell attracting chemokine leukocyte chemoattractant-ligand (C-X-C motif) 13 (CXCL13) in early breast cancer. METHODS: The study is based on the patient population of the randomized FinHer trial, where 1010 patients with early breast cancer were randomly allocated to adjuvant chemotherapy containing either docetaxel or vinorelbine, and human epidermal growth factor receptor 2 (HER2)-positive patients were also allocated to trastuzumab or no trastuzumab...
February 26, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29324261/platelet-toll-like-receptor-and-its-ligand-hmgb-1-expression-is-increased-in-the-left-atrium-of-atrial-fibrillation-patients
#12
Kadri Murat Gurses, Duygu Kocyigit, Muhammed Ulvi Yalcin, Hande Canpinar, Banu Evranos, Ugur Canpolat, Hikmet Yorgun, Levent Sahiner, Dicle Guc, Kudret Aytemir
BACKGROUND: Atrial fibrillation(AF) is the most common sustained arrhythmia. Its most feared sequelae are stroke and peripheral thromboembolism due to atrial thrombi formation. Mechanisms underlying the relationship between platelet activation and left atrial thrombi have not been clearly elucidated yet. We aimed to investigate whether immune-mediated platelet activation occurred in AF patients in this cross-sectional study. METHODS: Persistent and paroxysmal AF patients who underwent cryoballoon-based AF ablation between March 2015 and July 2016 were included as the patient group...
March 2018: Cytokine
https://www.readbyqxmd.com/read/29322374/echocardiographic-assessment-of-regional-right-ventricular-systolic-function-using-two-dimensional-strain-echocardiography-and-evaluation-of-the-predictive-ability-of-longitudinal-2d-strain-imaging-for-pulmonary-arterial-hypertension-in-systemic-sclerosis-patients
#13
Vedat Hekimsoy, Ergun Barıs Kaya, Ali Akdogan, Levent Sahiner, Banu Evranos, Ugur Canpolat, Kudret Aytemir, Necla Özer, Lale Tokgozoglu
Systemic sclerosis (SSc) is a generalized connective tissue disorder, and SSc patients are at risk of developing pulmonary arterial hypertension (PAH). The aims of this study are to evaluate the right ventricular regional systolic function using two-dimensional speckle-tracking echocardiography (2D STE) and to determine the predictive ability of peak longitudinal systolic strain (PLSS) at the RV lateral wall for PAH in SSc patients. 80 SSc patients (mean age 51 ± 12 years) were included in the study. Echocardiography and 2D STE were performed at baseline and after 12 months...
January 10, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29285878/a-comparison-of-the-effectiveness-of-silibinin-and-resveratrol-in-preventing-alpha-amanitin-induced-hepatotoxicity
#14
Aynur Sahin, Mualla Aylin Arici, Yeliz Yilmaz, Sule Kalkan, Nergiz Durmus, Bekir Ugur Ergur, Ilkay Yakut Aksu, Neşe Atabey, Yesim Tuncok
Amanita phalloides species mushrooms containing alpha-amanitin (α-AMA) are responsible for the majority of fatal mushroom intoxications and can lead to severe poisonings resulting in hepatotoxicity and acute hepatic failure. Existing antidotes, such as silibinin, are not sufficiently effective in the prevention and/or resolution of α-AMA-induced hepatotoxicity. We investigated the effects of resveratrol on α-AMA-induced hepatotoxicity and compared with silibinin, a known antidote using in vivo and in vitro toxicity models...
December 29, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29275847/self-amplifying-rna-vaccines-give-equivalent-protection-against-influenza-to-mrna-vaccines-but-at-much-lower-doses
#15
Annette B Vogel, Laura Lambert, Ekaterina Kinnear, David Busse, Stephanie Erbar, Kerstin C Reuter, Lena Wicke, Mario Perkovic, Tim Beissert, Heinrich Haas, Stephen T Reece, Ugur Sahin, John S Tregoning
New vaccine platforms are needed to address the time gap between pathogen emergence and vaccine licensure. RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in response to pathogen emergence. Two RNA vaccine platforms are available: synthetic mRNA molecules encoding only the antigen of interest and self-amplifying RNA (sa-RNA). sa-RNA is virally derived and encodes both the antigen of interest and proteins enabling RNA vaccine replication...
February 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29234532/bilateral-same-session-ureterorenoscopy-a-feasible-approach-to-treat-pan-urinary-stone-disease
#16
Bora Özveren, Murat Tugrul Eren, Hakan Özveri, Uğur Altuğ, Ahmet Şahin
Objectives: To assess treatment effectiveness and safety of bilateral same-session ureterorenoscopy (BSSU) for the management of stone disease involving the entire urinary system. Patients and methods: We reviewed the records of 64 patients who underwent BSSU for the treatment of bilateral ureteric and/or kidney stones. Size, number, location per side, and the total burden of stones were recorded. Data on stenting, lithotripsy, and stone retrieval, and details of hospital stay and operation times were investigated...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29232557/myeloid-cell-derived-reactive-oxygen-species-induce-epithelial-mutagenesis
#17
Özge Canli, Adele M Nicolas, Jalaj Gupta, Fabian Finkelmeier, Olga Goncharova, Marina Pesic, Tobias Neumann, David Horst, Martin Löwer, Ugur Sahin, Florian R Greten
Increased oxidative stress has been suggested to initiate and promote tumorigenesis by inducing DNA damage and to suppress tumor development by triggering apoptosis and senescence. The contribution of individual cell types in the tumor microenvironment to these contrasting effects remains poorly understood. We provide evidence that during intestinal tumorigenesis, myeloid cell-derived H2 O2 triggers genome-wide DNA mutations in intestinal epithelial cells to stimulate invasive growth. Moreover, increased reactive oxygen species (ROS) production in myeloid cells initiates tumor growth in various organs also in the absence of a carcinogen challenge in a paracrine manner...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232147/incorporation-of-mrna-in-lamellar-lipid-matrices-for-parenteral-administration
#18
Antje Ziller, Sara S Nogueira, Eva Hühn, Sergio S Funari, Gerald Brezesinski, Hermann Hartmann, Ugur Sahin, Heinrich Haas, Peter Langguth
Insertion of high molecular weight messenger RNA (mRNA) into lyotropic lipid phases as model systems for controlled release formulations for the mRNA was investigated. Low fractions of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) were used as an anchor to load the mRNA into a lamellar lipid matrix. Dispersions of zwitterionic lipid in the aqueous phase in the presence of increasing fractions of mRNA and cationic lipid were prepared, and the molecular organization was investigated as a function of mRNA and cationic lipid fraction...
February 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29205803/septal-reduction-therapy-using-nonalcohol-agent-in-hypertrophic-obstructive-cardiomyopathy-single-center-experience
#19
Serkan Asil, Barış Kaya, Uğur Canpolat, Hikmet Yorgun, Levent Şahiner, Cem Çöteli, Anıl Arat, Kudret Aytemir
AIMS: Percutaneous septal reduction therapy by either alcohol or nonalcohol agents is an alternative approach to surgery in drug-refractory symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). Nonalcohol agents have some advantages and disadvantages over alcohol during the procedure. Nowadays, a novel non-alcohol agent, named as Ethylene-vinyl alcohol (EVOH) copolymer (Onyx® and Squid® ), is used during septal ablation. Thus, in this study, we aimed to evaluate both acute and long-term efficacy and safety profile of EVOH during septal ablation in HOCM...
December 5, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29203786/antigen-specific-oncolytic-mv-based-tumor-vaccines-through-presentation-of-selected-tumor-associated-antigens-on-infected-cells-or-virus-like-particles
#20
Stefan Hutzler, Stephanie Erbar, Robert A Jabulowsky, Jan R H Hanauer, Jürgen H Schnotz, Tim Beissert, Bianca S Bodmer, Regina Eberle, Klaus Boller, Thorsten Klamp, Ugur Sahin, Michael D Mühlebach
Recombinant vaccine strain-derived measles virus (MV) is clinically tested both as vaccine platform to protect against other pathogens and as oncolytic virus for tumor treatment. To investigate the potential synergism in anti-tumoral efficacy of oncolytic and vaccine properties, we chose Ovalbumin and an ideal tumor antigen, claudin-6, for pre-clinical proof of concept. To enhance immunogenicity, both antigens were presented by retroviral virus-like particle produced in situ during MV-infection. All recombinant MV revealed normal growths, genetic stability, and proper expression and presentation of both antigens...
December 4, 2017: Scientific Reports
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