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https://www.readbyqxmd.com/read/28247842/leukemia-inhibitory-factor-promotes-aggressiveness-of-chordoma
#1
Sukru Gulluoglu, Mesut Sahin, Emre Can Tuysuz, Cumhur Kaan Yaltirik, Aysegul Kuskucu, Ferda Ozkan, Fikrettin Sahin, Ugur Ture, Omer Faruk Bayrak
Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemo- and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential, and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. The leukemia inhibitory factor has multiple functions in stem-cell biology, the immune response, and cancer, and is potentially a key molecule that allows cancer stem cells to self-renew...
February 28, 2017: Oncology Research
https://www.readbyqxmd.com/read/28184327/the-effects-of-monosodium-glutamate-and-tannic-acid-on-adult-rats
#2
Ibrahim Ugur Calis, Didem Turgut Cosan, Faruk Saydam, Umut Kerem Kolac, Ahu Soyocak, Hulyam Kurt, Hasan Veysi Gunes, Varol Sahinturk, Fezan Sahin Mutlu, Zeynep Ozdemir Koroglu, Irfan Degirmenci
BACKGROUND: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. The excessive use of MSG has been shown to increase oxidative stress in different organ systems and causes glucose metabolism disorders, obesity, and coronary diseases. OBJECTIVES: In this study, the antioxidant activity of tannic acid was investigated experimentally with respect to its protective effects against overdosed MSG-induced oxidative stress in rats...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28158215/in-silico-analyses-and-global-transcriptional-profiling-reveal-novel-putative-targets-for-pea3-transcription-factor-related-to-its-function-in-neurons
#3
Başak Kandemir, Ugur Dag, Burcu Bakir Gungor, İlknur Melis Durasi, Burcu Erdogan, Eray Sahin, Ugur Sezerman, Isil Aksan Kurnaz
Pea3 transcription factor belongs to the PEA3 subfamily within the ETS domain transcription factor superfamily, and has been largely studied in relation to its role in breast cancer metastasis. Nonetheless, Pea3 plays a role not only in breast tumor, but also in other tissues with branching morphogenesis, including kidneys, blood vasculature, bronchi and the developing nervous system. Identification of Pea3 target promoters in these systems are important for a thorough understanding of how Pea3 functions. Present study particularly focuses on the identification of novel neuronal targets of Pea3 in a combinatorial approach, through curation, computational analysis and microarray studies in a neuronal model system, SH-SY5Y neuroblastoma cells...
2017: PloS One
https://www.readbyqxmd.com/read/28088684/changes-in-electroencephalographic-characteristics-and-blood-brain-barrier-permeability-in-wag-rij-rats-with-cortical-dysplasia
#4
Deniz Sahin, Canan Ugur Yilmaz, Nurcan Orhan, Nadir Arican, Mehmet Kaya, Candan Gürses, Nurbay Ates, Bulent Ahishali
PURPOSE: This study investigated the effects of cortical dysplasia (CD) on electrophysiology and blood-brain barrier (BBB) permeability in WAG/Rij rats with genetic absence epilepsy. METHODS: Pregnant WAG/Rij rats were exposed to 145cGy of gamma-irradiation on embryonic day 17 to induce CD. An electroencephalogram was recorded from cortices subdurally in the offspring of the pregnant animals. Horseradish peroxidase (HRP) was used as determinant of BBB permeability...
February 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28079610/influence-of-the-localization-of-frontal-bone-defects-on-primary-stability-values-of-2-different-implant-designs-an-in-vitro-study
#5
Ugur Mercan, Hakan Bilhan, Deniz Gokce Meral, Sehnaz Kazokoglu, Gokce Aykol-Sahin, Onur Geckili
OBJECTIVES: The aim of this study was to determine the influence of different frontal bone defect localizations on primary stability values of 2 different implant designs. MATERIALS AND METHODS: Eight cow rib segments were prepared before implant installation, as 2 segments with coronal, 2 with middle, and 2 with apical defects and 2 with control. Thirty-two cylindrical and 32 tapered implants were placed in the remaining 4 segments. Implant stability measurements were performed using electronic percussive testing and resonance frequency analysis...
February 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28058217/review-of-allogeneic-hematopoietic-stem-cell-transplantation-with-reduced-intensity-conditioning-in-solid-tumors-excluding-breast-cancer
#6
REVIEW
Nuri Karadurmus, Ugur Sahin, Bilgin Bahadir Basgoz, Fikret Arpaci, Taner Demirer
Solid tumors in adults constitute a heterogeneous group of malignancy originating from various organ systems. Solid tumors are not completely curable by chemotherapy, even though some subgroups are very chemo-sensitive. Recently, oncologists have focused on the use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with reduced intensity conditioning (RIC) for the treatment of some refractory solid tumors. After the demonstration of allogeneic graft-versus-leukemia effect in patients with hematological malignancies who received allo-HSCT, investigators evaluated this effect in patients with refractory metastatic solid tumors...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28011121/temporal-bone-paragangliomas-15-years-experience
#7
Mehmet Düzlü, Hakan Tutar, Recep Karamert, Furkan Karaloğlu, Muammer Melih Şahin, Mehmet Göcek, Mehmet Birol Uğur, Nebil Göksu
INTRODUCTION: Temporal bone paragangliomas (TBPs) are benign tumors arising from neural crest cells located along the jugular bulbus and the tympanic plexus. In general surgical excision, radiotherapy and wait-and-scan protocols are the main management modalities for TBPs. OBJECTIVE: In this paper we aim to present our clinical experience with TBPs and to review literature data. METHODS: The patients who were operated for tympanomastoid paraganglioma (TMP) or tympanojugular paraganglioma (TJP) in our clinic in the last 15 years were enrolled in the study...
December 8, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27987153/discovery-and-subtyping-of-neo-epitope-specific-t-cell-responses-for-cancer-immunotherapy-addressing-the-mutanome
#8
Mustafa Diken, Mathias Vormehr, Christian Grunwitz, Sebastian Kreiter, Özlem Türeci, Ugur Sahin
Cancer accumulates 10s to 1000s of genomic mutations of which a fraction is immunogenic and may serve as an Achilles' heel of tumor cells. Mutation-specific T cells can recognize these antigens and destroy malignant cells. Strategies to immunotherapeutically address individual tumor mutations employing peptide or mRNA based vaccines are now actively investigated in mice and humans. An important step of determining the therapeutic potential of a mutanome vaccine is the detection of mutation reactive T-cell responses...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27987152/the-european-regulatory-environment-of-rna-based-vaccines
#9
Thomas Hinz, Kajo Kallen, Cedrik M Britten, Bruno Flamion, Ulrich Granzer, Axel Hoos, Christoph Huber, Samir Khleif, Sebastian Kreiter, Hans-Georg Rammensee, Ugur Sahin, Harpreet Singh-Jasuja, Özlem Türeci, Ulrich Kalinke
A variety of different mRNA-based drugs are currently in development. This became possible, since major breakthroughs in RNA research during the last decades allowed impressive improvements of translation, stability and delivery of mRNA. This article focuses on antigen-encoding RNA-based vaccines that are either directed against tumors or pathogens. mRNA-encoded vaccines are developed both for preventive or therapeutic purposes. Most mRNA-based vaccines are directly administered to patients. Alternatively, primary autologous cells from cancer patients are modified ex vivo by the use of mRNA and then are adoptively transferred to patients...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27903882/cap-analogs-modified-with-1-2-dithiodiphosphate-moiety-protect-mrna-from-decapping-and-enhance-its-translational-potential
#10
Malwina Strenkowska, Renata Grzela, Maciej Majewski, Katarzyna Wnek, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Edward Darzynkiewicz, Andreas N Kuhn, Ugur Sahin, Jacek Jemielity
Along with a growing interest in mRNA-based gene therapies, efforts are increasingly focused on reaching the full translational potential of mRNA, as a major obstacle for in vivo applications is sufficient expression of exogenously delivered mRNA. One method to overcome this limitation is chemically modifying the 7-methylguanosine cap at the 5' end of mRNA (m(7)Gppp-RNA). We report a novel class of cap analogs designed as reagents for mRNA modification. The analogs carry a 1,2-dithiodiphosphate moiety at various positions along a tri- or tetraphosphate bridge, and thus are termed 2S analogs...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27862745/infliximab-induced-cutaneous-eruption-resembling-pityriasis-rubra-pilaris-in-a-patient-with-takayasu-s-arteritis
#11
Andac Salman, Yaman Sonmez, Hulya Sahin, Ali Ugur Unal, Haner Direskeneli, Leyla Cinel, Tulin Ergun
No abstract text is available yet for this article.
November 12, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27823643/an-overview-of-hematopoietic-stem-cell-transplantation-related-thrombotic-complications
#12
REVIEW
Ugur Sahin, Pinar Ataca Atilla, Erden Atilla, Selami Kocak Toprak, Taner Demirer
Thrombotic episodes are far less common than bleeding complications after hematopoietic stem cell transplantation (HSCT). However, they lead to significant morbidity and mortality. These complications are classified into four groups, including venous thromboembolic events (VTE), catheter-induced thrombosis (CIT), transplant-associated thrombotic microangiopathy (TA-TMA) and sinusoidal obstruction syndrome (SOS) or veno-occlusive disease (VOD). The frequency of VTE is increased among patients undergoing HSCT due to some acquired conditions including underlying malignancy, infections, administration of myeloablative conditioning regimens and/or total body irradiation, prolonged hospitalizations leading to immobility and presence of central venous catheters...
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27801664/mrna-a-versatile-molecule-for-cancer-vaccines
#13
REVIEW
Mustafa Diken, Lena M Kranz, Sebastian Kreiter, Ugur Sahin
mRNA vaccines are finally ready to assume their rightful place at the forefront of nucleic acid- based vaccines. Major achievements within the last two decades have turned this highly versatile molecule into a safe and very attractive pharmaceutical platform that combines many positive attributes able to address a broad range of diseases, including cancer. The simplicity of mRNA vaccines greatly reduces complications generally associated with the production of biological vaccines. Intrinsic costimulatory and inflammatory triggers in addition to the provision of the antigenic information makes mRNA an all- in-one molecule that does not need additional adjuvants and that does not pose the risk of genomic integration...
2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/27719802/past-present-and-future-of-immunology-in-mainz
#14
Ari Waisman, Nadine Hövelmeyer, Andreas Diefenbach, Detlef Schuppan, Mathhias J Reddehase, Hartmut Kleinert, Bernd Kaina, Stephan Grabbe, Peter R Galle, Matthias Theobald, Frauke Zipp, Ugur Sahin, Öslem Türeci, Sebastian Kreiter, Peter Langguth, Heinz Decker, Ger van Zandbergen, Hansjörg Schild
No abstract text is available yet for this article.
October 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27704624/extended-locoregional-use-of-intercostal-artery-perforator-propeller-flaps
#15
Semih Baghaki, Murat Diyarbakirlioglu, Ugur Sahin, Muge Anil Kucuksucu, Akif Turna, Bilgi Baca, Yağmur Aydın
Besides conventional flaps, intercostal artery perforator flaps have been reported to cover trunk defects. In this report the use of anterior intercostal artery perforator (AICAP) flap, lateral intercostal artery perforator (LICAP) flap and dorsal intercostal artery perforator (DICAP) flap for thoracic, abdominal, cervical, lumbar and sacral defects with larger dimensions and extended indications beyond the reported literature were reevaluated. Thirty-nine patients underwent surgery between August 2012 and August 2014...
October 5, 2016: Microsurgery
https://www.readbyqxmd.com/read/27700619/translating-nanoparticulate-personalized-cancer-vaccines-into-clinical-applications-case-study-with-rna-lipoplexes-for-the-treatment-of-melanoma
#16
Stephan Grabbe, Heinrich Haas, Mustafa Diken, Lena M Kranz, Peter Langguth, Ugur Sahin
The development of nucleic acid based vaccines against cancer has gained considerable momentum through the advancement of modern sequencing technologies and on novel RNA-based synthetic drug formats, which can be readily adapted following identification of every patient's tumor-specific mutations. Furthermore, affordable and individual 'on demand' production of molecularly optimized vaccines should allow their application in large groups of patients. This has resulted in the therapeutic concept of an active personalized cancer vaccine, which has been brought into clinical testing...
October 2016: Nanomedicine
https://www.readbyqxmd.com/read/27529584/first-case-of-percutaneous-left-atrial-appendage-closure-by-amulet%C3%A2-device-in-a-patient-with-left-atrial-appendage-thrombus
#17
Kudret Aytemir, Adel Aminian, Serkan Asil, Uğur Canpolat, Ergün Barış Kaya, Levent Şahiner, Banu Evranos, Hikmet Yorgun, Necla Özer
No abstract text is available yet for this article.
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27487282/the-acute-effects-of-preoperative-ozone-theraphy-on-surgical-wound-healing
#18
Hasan Sahin, Tuncer Simsek, Hakan Turkon, Yıldıray Kalkan, Faruk Ozkul, M Turgut Alper Ozkan, Mesut Erbas, Ugur Altinisik, Yavuz Demiraran
PURPOSE: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes. METHODS: Twenty one rabbits were divided into 3 groups. Sham, surgical wound, and ozone applied (6 sessions, every other day 70 µg/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour...
July 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27422115/uptake-of-synthetic-naked-rna-by-skin-resident-dendritic-cells-via-macropinocytosis-allows-antigen-expression-and-induction-of-t-cell-responses-in-mice
#19
Abderraouf Selmi, Fulvia Vascotto, Kordula Kautz-Neu, Özlem Türeci, Ugur Sahin, Esther von Stebut, Mustafa Diken, Sebastian Kreiter
Intradermal administration of antigen-encoding RNA has entered clinical testing for cancer vaccination. However, insight into the underlying mechanism of RNA uptake, translation and antigen presentation is still limited. Utilizing pharmacologically optimized naked RNA, the dose-response kinetics revealed a rise in reporter signal with increasing RNA amounts and a prolonged RNA translation of reporter protein up to 30 days after intradermal injection. Dendritic cells (DCs) in the dermis were shown to engulf RNA, and the signal arising from the reporter RNA was significantly diminished after DC depletion...
September 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27405663/a-rare-%C3%AE-pyranopyrazole-skeleton-design-one-pot-synthesis-and-computational-study
#20
Muhammed Üçüncü, Ceren Cantürk, Erman Karakuş, Hüseyin Zeybek, Uğur Bozkaya, Emine Soydaş, Ertan Şahin, Mustafa Emrullahoğlu
Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a range of pyrazole fused γ-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of γ-pyranopyrazole is furthermore fully supported by experimental and computational studies.
August 21, 2016: Organic & Biomolecular Chemistry
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