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https://www.readbyqxmd.com/read/29691917/an-immunological-age-index-in-bipolar-disorder-a-confirmatory-factor-analysis-of-putative-immunosenescence-markers-and-associations-with-clinical-characteristics
#1
Lucas B Rizzo, Walter Swardfager, Pawan Kumar Maurya, Maiara Zeni Graiff, Mariana Pedrini, Elson Asevedo, Ana Cláudia Cassinelli, Moisés E Bauer, Quirino Cordeiro, Jan Scott, Elisa Brietzke, Hugo Cogo-Moreira
OBJECTIVES: The study aims to generate an immunological age (IA) trait on the basis of immune cell differentiation parameters, and to test whether the IA is related to age and disease characteristics. METHODS: Forty-four euthymic type I bipolar disorder patients were included in this study. Five immunosenescence-related parameters were assessed: proportions of late-differentiated cells (e.g., CD3+CD8+CD28-CD27- and CD3-CD19+IgD-CD27-), and the expression of CD69, CD71, and CD152 after stimulation...
April 25, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#2
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29691808/total-body-irradiation-for-hematopoietic-stem-cell-transplantation-during-early-childhood-is-associated-with-the-risk-for-diabetes-mellitus
#3
Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies and related diseases. Recently, the long-term prognosis of HSCT during childhood has greatly improved; however, the late adverse effects of HSCT have been found to cause substantial morbidity among long-term survivors. Although metabolic complications, such as diabetes mellitus (DM) and hyperlipidemia (HL), are the major late effects of pediatric HSCT, the clinical details are not clarified sufficiently...
April 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29691711/biomechanics-and-mechanical-signaling-in-the-ovary-a-systematic-review
#4
REVIEW
Jaimin S Shah, Reem Sabouni, Kamaria C Cayton Vaught, Carter M Owen, David F Albertini, James H Segars
PURPOSE: Mammalian oogenesis and folliculogenesis share a dynamic connection that is critical for gamete development. For maintenance of quiescence or follicular activation, follicles must respond to soluble signals (growth factors and hormones) and physical stresses, including mechanical forces and osmotic shifts. Likewise, mechanical processes are involved in cortical tension and cell polarity in oocytes. Our objective was to examine the contribution and influence of biomechanical signaling in female mammalian gametogenesis...
April 24, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29691681/the-impact-of-the-ryan-white-hiv-aids-medical-case-management-program-on-hiv-clinical-outcomes-a-longitudinal-study
#5
Julia D López, Enbal Shacham, Tawnya Brown
Medical case management (MCM) is a core medical service in The Ryan White HIV/AIDS Program and aims to provide treatment and care for people living with HIV/AIDS by engaging, identifying and eliminating barriers to HIV care. Little research has examined the impact of this intervention; therefore, the purpose of this study was to examine the how MCM affects HIV clinical outcomes. The study took place at a midwestern, outpatient infectious diseases clinic. This study utilized a longitudinal, retrospective study design to analyze to the impact of MCM engagement on HIV clinical outcomes (viral loads, CD4 counts) from 2009 to 2015 as a time-varying predictor...
April 24, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29691590/enhancer-reprogramming-in-tumor-progression-a-new-route-towards-cancer-cell-plasticity
#6
REVIEW
Luca Fagnocchi, Vittoria Poli, Alessio Zippo
Cancer heterogeneity arises during tumor progression as a consequence of genetic insults, environmental cues, and reversible changes in the epigenetic state, favoring tumor cell plasticity. The role of enhancer reprogramming is emerging as a relevant field in cancer biology as it supports adaptation of cancer cells to those environmental changes encountered during tumor progression and metastasis seeding. In this review, we describe the cancer-related alterations that drive oncogenic enhancer activity, leading to dysregulated transcriptional programs...
April 24, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29691578/-effects-of-thyroid-hormone-on-macrophage-dysfunction-induced-by-oxidized-low-density-lipoprotein
#7
Yu Ning, Ming Zhang, Yun-Hui DU, Hui-Na Zhang, Lin-Yi Li, Yan-Wen Qin, Wan-Wan Wen, Quan-Ming Zhao
It has been recognized that patients with hypothyroidism have higher risks of atherosclerosis and coronary heart disease, however, the mechanisms are largely unknown. Considering that macrophage dysfunction plays an important role in the formation and development of atherosclerosis plaques, this study aimed to investigate the direct effects of thyroid hormone on macrophage functions and to provide new insight for the mechanism of hypothyroid atherosclerosis. RAW264.7 cells (mouse leukaemic monocyte macrophage cell line) were incubated with oxidized low-density lipoprotein (oxLDL) to establish macrophage foam cells model in vitro, and the protective effects of different concentration of thyroxine (T4) on the macrophage foam cells function were explored...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29691554/-retrospective-analysis-of-896-cases-of-parotid-gland-tumor
#8
Zhi-Guo Zhao, Dan Gao, Jin Wang, Li-Ping Zhang
PURPOSE: To review the clinical data of patients undergoing operation, in order to summarize the incidence, proportion, clinical examination and diagnostic methods of parotid tumors. METHODS: Eight hundred and ninty-six cases of parotid gland tumors were collected from 2008 January to 2015 July from department of oral and maxillofacial surgery in Shengjing Hospital of China Medical University. A retrospective study of the clinical data was carried out, including age, gender, tumor location, diagnostic methods and pathological results...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691328/genetic-ablation-of-all-cerebellins-reveals-synapse-organizer-functions-in-multiple-regions-throughout-the-brain
#9
Erica Seigneur, Thomas C Südhof
Cerebellins are synaptic organizer molecules that bind to presynaptic neurexins and postsynaptic receptors. Cerebellins are well studied in cerebellum, but three of the four cerebellins (Cbln1, Cbln2, and Cbln4) are also broadly expressed outside of the cerebellum, suggesting that they perform general functions throughout the brain. Here we generated male and female single, double, and triple constitutive KO mice of Cbln1, Cbln2, and Cbln4. We found that all constitutive cerebellin-deficient mice are viable and fertile, suggesting that cerebellins are not essential for survival...
April 24, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29691190/noni-morinda-citrifolia-l-fruit-juice-delays-immunosenescence-in-the-lymphocytes-in-lymph-nodes-of-old-f344-rats
#10
Uday P Pratap, Hannah P Priyanka, Karthik R Ramanathan, Vishak Raman, Lalgi Hima, Srinivasan Thyagarajan
OBJECTIVE: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni (M. citrifolia) fruit juice (NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats. METHODS: Lymphocytes isolated from axillary and inguinal lymph nodes of young (3-4 months) and old (18-21 months) rats were treated in vitro with different concentrations (0...
April 12, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29691151/red-blood-cells-still-vital-after-all-these-years-commentary-on-canadian-blood-services-international-symposium-2017
#11
REVIEW
Syed M Qadri, David A Donkor, Matthew Yan, Shuoyan Ning, Donald R Branch, Jerard Seghatchian, William P Sheffield
Canadian Blood Services (CBS), Canada's national blood transfusion service, has for many years sponsored an annual conference, for the education and awareness of interested participants, showcasing the latest evidence-based understanding of both basic science and clinical issues in transfusion medicine and science. The 15th iteration of this symposium took place September 9, 2017 and focused on some of the vital aspects of red blood cells (RBC), in line with the" 3Rs" concept, namely the provision of the Right red blood cell (RBC) product to the Right patient at the Right time...
April 19, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29690924/the-effect-of-regularly-dosed-paracetamol-versus-no-paracetamol-on-renal-function-in-plasmodium-knowlesi-malaria-packnow-study-protocol-for-a-randomised-controlled-trial
#12
Daniel J Cooper, Katherine Plewes, Matthew J Grigg, Giri S Rajahram, Kim A Piera, Timothy William, Mark D Chatfield, Tsin Wen Yeo, Arjen M Dondorp, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29690880/abnormal-pulmonary-function-tests-predict-the-development-of-radiation-induced-pneumonitis-in-advanced-non-small-cell-lung-cancer
#13
L Torre-Bouscoulet, W R Muñoz-Montaño, D Martínez-Briseño, F J Lozano-Ruiz, R Fernández-Plata, J A Beck-Magaña, C García-Sancho, A Guzmán-Barragán, E Vergara, M Blake-Cerda, L Gochicoa-Rangel, F Maldonado, M Arroyo-Hernández, O Arrieta
BACKGROUND: Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predict RP in non-small cell lung cancer (NSCLC) patients. METHODS: A prospective multi-institutional study was conducted with locally advanced and oligometastatic NSCLC patients...
April 24, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29690665/-spindle-cell-lipoma-and-pleomorphic-lipoma-a-clinicopathologic-analysis-of-65-cases
#14
L H Tang, Q Y Lao, L Yu, J Wang
Objective: To investigate the clinical and pathological features of spindle cell lipoma (SCL) and pleomorphic lipoma (PL) with emphasis on differential diagnosis. Methods: Sixty-five cases of SCL/PL from the archive of Department of Pathology, Fudan University Shanghai Cancer Center, from August of 2006 to June of 2017, were included in the study. Immunohistochemistry by EnVision method, MDM2 gene amplifycation and DDIT3 gene translocation by fluorescence in situ hybridization(FISH) were detected and the literature was reviewed...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29690664/-clinicopathologic-features-of-gastric-plexiform-fibromyxoma
#15
G M Hu, H P Chen, Q Y Liu, X C Shi, H F Wu, Y K Feng, J L Ren, C F Wang
Objective: To analyse the clinicopathologic features of gastric plexiform fibromyxoma (PF) including diagnosis, differential diagnosis, immunohistochemistry and molecular pathology. Methods: Eight cases of PF were collected from June 2006 to June 2017 at the Second Affiliated Hospital of Zhengzhou University and the First Affiliated Hospital of Zhengzhou University. The clinicopathologic findings of eight cases of PF were retrospectively analyzed, and immunohistochemistry (EnVision method) and molecular detection of glioma-associated oncogene homologue 1 (GLI1) gene translocation were performed...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29690663/-expression-of-succinate-dehydrogenase-subunit-protein-in-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors
#16
Y J Zhang, Y H Cheng, L X Guo, N Q Wang, H Liu
Objective: To investigate the expression of succinate dehydrogenase complex subunit protein in succinate dehydrogenase-deficient gastrointestinal stromal tumors (SDH-deficient GISTs). Methods: Three hundred fifty-two cases of GISTs were collected from January 2003 to January 2017 at the Affiliated Hospital of Guizhou Medical University and West China Hospital of Sichuan University.The expression of succinate dehydrogenase subunit protein was detected by immunohistochemical EnVision technique in 352 cases of GISTs, and the negative cases were analyzed for clinicopathologic features and outcome...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29689740/pilot-feasibility-study-to-detect-mesenchymal-stem-cell-biomarkers-of-bronchopulmonary-dysplasia-in-the-tracheal-aspirate-fluid-of-preterm-infants
#17
R G LaGrandeur, M Singhal, F Bany-Mohammed, C Uy, R Koeppel, F Zaldivar, F Haddad, A Nalbandian, P Donovan, D M Cooper, M Aslam
OBJECTIVE: This study aimed to detect novel mesenchymal stem cell peptides/biomarkers of bronchopulmonary dysplasia (BPD) in the tracheal aspirate fluid (TAF) of preterm infants. STUDY DESIGN: Participants included infants less than 32 weeks' gestational age or birth weight under 1500 grams who required endotracheal intubation and mechanical ventilation within first 24 hours of life. TAF sample collection was performed at the time of the first clinically indicated routine suctioning...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689729/memory-loss-and-the-onset-of-alzheimer-s-disease-could-be-under-the-control-of-extracellular-heat-shock-proteins
#18
Nelson Arispe, Antonio De Maio
Alzheimer's disease (AD) is a major contemporary and escalating malady in which amyloid-β (Aβ) peptides are the most likely causative agent. Aβ peptides spontaneously tend to aggregate in extracellular fluids following a progression from a monomeric state, through intermediate forms, ending in amyloid fibers and plaques. It is generally accepted now that the neurotoxic agents leading to cellular death, memory loss, and other AD characteristics are the Aβ intermediate aggregated states. However, Aβ peptides are continuously produced, released into the extracellular space, and rapidly cleared from healthy brains...
April 17, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689723/stereological-investigation-of-the-effects-of-treadmill-running-exercise-on-the-hippocampal-neurons-in-middle-aged-app-ps1-transgenic-mice
#19
Fenglei Chao, Lin Jiang, Yi Zhang, Chunni Zhou, Lei Zhang, Jing Tang, Xin Liang, Yingqiang Qi, Yanqing Zhu, Jing Ma, Yong Tang
The risk of cognitive decline during Alzheimer's disease (AD) can be reduced if physical activity is maintained; however, the specific neural events underlying this beneficial effect are still uncertain. To quantitatively investigate the neural events underlying the effect of running exercise on middle-aged AD subjects, 12-month-old male APP/PS1 mice were randomly assigned to a control group or running group, and age-matched non-transgenic littermates were used as a wild-type group. AD running group mice were subjected to a treadmill running protocol (regular and moderate intensity) for four months...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689628/myotendinous-junction-plasticity-in-aged-ovariectomized-rats-submitted-to-aquatic-training
#20
Luan Rissatto Sierra, Gabriel Fávaro, Bruno Rubin Cerri, Lara Caetano Rocha, Sonia Regina de Yokomizo de Almeida, Ii-Sei Watanabe, Adriano Polican Ciena
The study aims to describe the tissue plasticity of MTJ through the morphological analysis of MTJ soleus in ovariectomized aged female Wistar rats submitted to aquatic training. Forty aged Wistar rats, 1 year and 2 months of age, were divided into four groups: sedentary (S), trained (T), ovariectomized (O), and trained/ovariectomized (OT). Employing the transmission electron microscopy, the ultrastructural and morphometric elements were revealed. In the S group, changes in morphological characteristics as a consequence of the aging process were seen, demonstrated by the conical shape of the muscle cell extremity, a large area with collagen deposit, and misalignment of sarcomeres in series...
April 24, 2018: Microscopy Research and Technique
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