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https://www.readbyqxmd.com/read/28241696/-changes-of-the-expression-for-genes-related-with-senescence-and-the-telomerase-activity-during-cellular-replicative-and-premature-senescence-in-human-embryonic-lung-fibroblasts
#1
J P Yang, W J Zhang, C X Jing, C P Wu, W D Ji, L Q Yang, Z X Zhuang
Objective: To detect the alterations of telomerase activity and the expression for oxidative stress responsive genes related with senescence during cellular replicative senescence and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts (HELFs) in vitro. Methods: The HELFs were divided into young cells (22 population doubling levels, 22PDL) , mid-aged cells (35PDL) and replicative senes-cent cells (49PDL) and premature senescent cells induced by H(2)O(2)(premature senescence, PS)...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28241428/an-automated-micro-total-immunoassay-system-for-measuring-cancer-associated-%C3%AE-2-3-linked-sialyl-n-glycan-carrying-prostate-specific-antigen-may-improve-the-accuracy-of-prostate-cancer-diagnosis
#2
Tomokazu Ishikawa, Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Tatsuo Kurosawa, Kenji Nakamura, Shintaro Narita, Koji Mitsuzuka, Wilhelmina Duivenvoorden, Jehonathan H Pinthus, Yasuhiro Hashimoto, Takuya Koie, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama
The low specificity of the prostate-specific antigen (PSA) for early detection of prostate cancer (PCa) is a major issue worldwide. The aim of this study to examine whether the serum PCa-associated α2,3-linked sialyl N-glycan-carrying PSA (S2,3PSA) ratio measured by automated micro-total immunoassay systems (μTAS system) can be applied as a diagnostic marker of PCa. The μTAS system can utilize affinity-based separation involving noncovalent interaction between the immunocomplex of S2,3PSA and Maackia amurensis lectin to simultaneously determine concentrations of free PSA and S2,3PSA...
February 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28241320/senescent-changes-and-topography-of-the-dark-adapted-multifocal-electroretinogram
#3
Athanasios Panorgias, Megan Tillman, Erich E Sutter, Ala Moshiri, Christina Gerth-Kahlert, John S Werner
Purpose: To investigate the topographic changes of the dark-adapted multifocal electroretinogram (mfERG) across adulthood in the central retina and compare the topography between macular versus extramacular, nasal versus temporal, and inferior versus superior retinal areas. Methods: Sixty-five subjects (18-88 years) received a comprehensive dilated eye examination to ensure the health of their retina and were tested with a dark-adapted mfERG protocol using a 61-hexagon pattern...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241315/development-of-a-chromatic-pupillography-protocol-for-the-first-gene-therapy-trial-in-patients-with-cnga3-linked-achromatopsia
#4
Jolanta Lisowska, Lukasz Lisowski, Carina Kelbsch, Fumiatsu Maeda, Paul Richter, Susanne Kohl, Ditta Zobor, Torsten Strasser, Krunoslav Stingl, Eberhart Zrenner, Tobias Peters, Helmut Wilhelm, M Dominik Fischer, Barbara Wilhelm
Purpose: To establish a feasible and sensitive pupillographic protocol to assess outer and inner retinal function for the first gene therapy trial in achromatopsia patients (ACHM) with mutations in CNGA3. Methods: Twenty-seven CNGA3-ACHM patients and 22 age-matched control subjects were tested using chromatic pupillography. Three different protocols were established to assess the pupillary light reflex parameters and to create the final protocol. In the individual protocols, various stimulus parameters (i...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241268/long-term-outcomes-after-autologous-hematopoietic-stem-cell-transplantation-for-multiple-sclerosis
#5
Paolo A Muraro, Marcelo Pasquini, Harold L Atkins, James D Bowen, Dominique Farge, Athanasios Fassas, Mark S Freedman, George E Georges, Francesca Gualandi, Nelson Hamerschlak, Eva Havrdova, Vassilios K Kimiskidis, Tomas Kozak, Giovanni L Mancardi, Luca Massacesi, Daniela A Moraes, Richard A Nash, Steven Pavletic, Jian Ouyang, Montserrat Rovira, Albert Saiz, Belinda Simoes, Marek Trnený, Lin Zhu, Manuela Badoglio, Xiaobo Zhong, Maria Pia Sormani, Riccardo Saccardi
Importance: Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies. Objective: To evaluate the long-term outcomes in patients who underwent AHSCT for the treatment of MS in a large multicenter cohort. Design, Setting, and Participants: Data were obtained in a multicenter, observational, retrospective cohort study. Eligibility criteria were receipt of AHSCT for the treatment of MS between January 1995 and December 2006 and the availability of a prespecified minimum data set comprising the disease subtype at baseline; the Expanded Disability Status Scale (EDSS) score at baseline; information on the administered conditioning regimen and graft manipulation; and at least 1 follow-up visit or report after transplant...
February 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28241261/outcomes-of-melanoma-in-situ-treated-with-mohs-micrographic-surgery-compared-with-wide-local-excision
#6
Adi Nosrati, Jacqueline G Berliner, Shilpa Goel, Joseph McGuire, Vera Morhenn, Juliana R de Souza, Yildiray Yeniay, Rasnik Singh, Kristina Lee, Mio Nakamura, Rachel R Wu, Ann Griffin, Barbara Grimes, Eleni Linos, Mary Margaret Chren, Roy Grekin, Maria L Wei
Importance: Melanoma in situ (MIS) is increasing in incidence, and expert consensus opinion recommends surgical excision for therapeutic management. Currently, wide local excision (WLE) is the standard of care. However, Mohs micrographic surgery (MMS) is now used to treat a growing subset of individuals with MIS. During MMS, unlike WLE, the entire cutaneous surgical margin is evaluated intraoperatively for tumor cells. Objective: To assess the outcomes of patients with MIS treated with MMS compared with those treated with WLE...
February 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28241148/cytosolic-proteostasis-through-importing-of-misfolded-proteins-into-mitochondria
#7
Linhao Ruan, Chuankai Zhou, Erli Jin, Andrei Kucharavy, Ying Zhang, Zhihui Wen, Laurence Florens, Rong Li
Loss of proteostasis underlies ageing and neurodegeneration characterized by the accumulation of protein aggregates and mitochondrial dysfunction. Although many neurodegenerative-disease-associated proteins can be found in mitochondria, it remains unclear how mitochondrial dysfunction and protein aggregation could be related. In dividing yeast cells, protein aggregates that form under stress or during ageing are preferentially retained by the mother cell, in part through tethering to mitochondria, while the disaggregase Hsp104 helps to dissociate aggregates and thereby enables refolding or degradation of misfolded proteins...
March 1, 2017: Nature
https://www.readbyqxmd.com/read/28241143/autophagy-maintains-the-metabolism-and-function-of-young-and-old-stem-cells
#8
Theodore T Ho, Matthew R Warr, Emmalee R Adelman, Olivia M Lansinger, Johanna Flach, Evgenia V Verovskaya, Maria E Figueroa, Emmanuelle Passegué
With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting haematopoietic stem cells from metabolic stress. Here we show that loss of autophagy in haematopoietic stem cells causes accumulation of mitochondria and an activated metabolic state, which drives accelerated myeloid differentiation mainly through epigenetic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potential...
March 1, 2017: Nature
https://www.readbyqxmd.com/read/28241106/future-of-testicular-germ-cell-tumor-incidence-in-the-united-states-forecast-through-2026
#9
Armen A Ghazarian, Scott P Kelly, Sean F Altekruse, Philip S Rosenberg, Katherine A McGlynn
BACKGROUND: Testicular germ cell tumors (TGCTs) are rare tumors in the general population but are the most commonly occurring malignancy among males between ages 15 and 44 years in the United States (US). Although non-Hispanic whites (NHWs) have the highest incidence in the US, rates among Hispanics have increased the most in recent years. To forecast what these incidence rates may be in the future, an analysis of TGCT incidence in the Surveillance, Epidemiology, and End Results program and the National Program of Cancer Registries was conducted...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28241096/the-prognostic-role-of-sex-race-and-human-papillomavirus-in-oropharyngeal-and-nonoropharyngeal-head-and-neck-squamous-cell-cancer
#10
Carole Fakhry, William H Westra, Steven J Wang, Annemieke van Zante, Yuehan Zhang, Eleni Rettig, Linda X Yin, William R Ryan, Patrick K Ha, Alicia Wentz, Wayne Koch, Jeremy D Richmon, David W Eisele, Gypsyamber D'Souza
BACKGROUND: Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs)...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28241095/immune-checkpoint-inhibitors-in-challenging-populations
#11
REVIEW
Douglas B Johnson, Ryan J Sullivan, Alexander M Menzies
Immune checkpoint inhibitors, including those targeting the programmed cell death 1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are revolutionizing cancer therapeutics. Both activity and toxicities largely stem from unleashing tumor- or host-specific cytotoxic T cells. Many patients seen in routine clinical practice have not qualified for or have been seriously underrepresented in immune checkpoint inhibitor clinical trials. Thus, a major gap in knowledge regarding the safety and efficacy of these agents persists in many populations, even after regulatory approval...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28241036/analysis-of-mycobacterium-ulcerans-specific-t-cell-cytokines-for-diagnosis-of-buruli-ulcer-disease-and-as-potential-indicator-for-disease-progression
#12
Norman Nausch, Daniel Antwi-Berko, Yusif Mubarik, Kabiru Mohammed Abass, Wellington Owusu, Ellis Owusu-Dabo, Linda Batsa Debrah, Alexander Yaw Debrah, Marc Jacobsen, Richard O Phillips
BACKGROUND: Buruli ulcer disease (BUD), caused by Mycobacterium (M.) ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy. BUD causes necrotic skin lesions and is a significant problem for health care in the affected countries. As for other mycobacterial infections, T cell mediated immune responses are important for protection and recovery during treatment, but detailed studies investigating these immune responses in BUD patients are scarce. In this study, we aimed to characterise M...
February 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28240973/late-relapse-of-classical-hodgkin-lymphoma-an-analysis-of-the-german-hodgkin-study-group-hd7-to-hd12-trials
#13
Paul J Bröckelmann, Helen Goergen, Charlotte Kohnhorst, Bastian von Tresckow, Alden Moccia, Jana Markova, Julia Meissner, Andrea Kerkhoff, Wolf-Dieter Ludwig, Michael Fuchs, Peter Borchmann, Andreas Engert
Purpose Clinical characteristics, therapeutic approaches, and prognosis of late relapse (LR) in patients with classic Hodgkin lymphoma (cHL) are poorly understood. We performed a comprehensive analysis of LR of Hodgkin lymphoma (LR-HL). Methods To estimate the incidence of LR-HL, we retrospectively analyzed 6,840 patients with cHL included in the German Hodgkin Study Group trials HD7 to HD12. Patients who experienced a relapse > 5 years into remission were compared with patients in continued remission for > 5 years and with those who experienced a relapse ≤ 5 years after first diagnosis...
February 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28240967/multicenter-phase-iii-randomized-double-blind-placebo-controlled-trial-of-pravastatin-added-to-first-line-standard-chemotherapy-in-small-cell-lung-cancer-lungstar
#14
Michael J Seckl, Christian H Ottensmeier, Michael Cullen, Peter Schmid, Yenting Ngai, Dakshinamoorthy Muthukumar, Joyce Thompson, Susan Harden, Gary Middleton, Kate M Fife, Barbara Crosse, Paul Taylor, Stephen Nash, Allan Hackshaw
Purpose Treating small-cell lung cancer (SCLC) remains a therapeutic challenge. Experimental studies show that statins exert additive effects with agents, such as cisplatin, to impair tumor growth, and observational studies suggest that statins combined with anticancer therapies delay relapse and prolong life in several cancer types. To our knowledge, we report the first large, randomized, placebo-controlled, double-blind trial of a statin with standard-of-care for patients with cancer, specifically SCLC. Patients and Methods Patients with confirmed SCLC (limited or extensive disease) and performance status 0 to 3 were randomly assigned to receive daily pravastatin 40 mg or placebo, combined with up to six cycles of etoposide plus cisplatin or carboplatin every 3 weeks, until disease progression or intolerable toxicity...
February 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28240897/development-of-1-2-4-oxadiazoles-as-potent-and-selective-inhibitors-of-the-human-deacetylase-sirtuin-2-structure-activity-relationship-x-ray-crystal-structure-and-anticancer-activity
#15
Sebastien Moniot, Mariantonietta Forgione, Alessia Lucidi, Gebremedhin Solomon Hailu, Angela Nebbioso, Vincenzo Carafa, Francesca Baratta, Lucia Altucci, Nicola Giacchè, Daniela Passeri, Roberto Pellicciari, Antonello Mai, Clemens Steegborn, Dante Rotili
Sirt2 is a target for the treatment of neurological, metabolic and age-related diseases including cancer. Here we report a series of Sirt2 inhibitors based on the 1,2,4-oxadiazole scaffold. These compounds are potent Sirt2 inhibitors active at single-digit μM level by using the Sirt2 substrate α-tubulin-acetylLys40 peptide, and inactive up to 100 μM against Sirt1, -3 and -5 (deacetylase and desuccinylase activities). Their mechanism of inhibition is uncompetitive towards both the peptide substrate and NAD+, and the crystal structure of a 1,2,4-oxadiazole analog in complex with Sirt2 and ADP-ribose reveals its orientation in a still unexplored sub cavity useful for further inhibitor development...
February 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28240846/identification-of-a-low-frequency-missense-variant-in-e2f-transcription-factor-7-associated-with-colorectal-cancer-risk-in-a-chinese-population
#16
Ai Ye Guo, Kan Zhai, Jin Ling Xu, Jin Long Hu, Lan Gao
Background: Transcription factors regulate gene expression and play important role in tumor genesis. Especially, the E2F transcription factor family controls the cell cycle and regulate many tumor suppressors. Missense variants in E2F family genes, which change the amino acid sequence, may alter the capacity for DNA binding or the protein structure, leading to a functional alteration. Material and Methods: We here searched for missense variants in E2F transcription family genes (E2F1~E2F8) and identified two (rs2075995 for E2F2 and rs3829295 for E2F7) with minor allele frequencies >0...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240745/the-biological-and-prognostic-significance-of-angiotropism-in-uveal-melanoma
#17
Raymond L Barnhill, Mengliang Ye, Aude Batistella, Marc-Henri Stern, Sergio Roman-Roman, Rémi Dendale, Olivier Lantz, Sophie Piperno-Neumann, Laurence Desjardins, Nathalie Cassoux, Claire Lugassy
Angiotropism is a marker of extravascular migration of melanoma cells along vascular and other structures and a prognostic factor in cutaneous melanoma. Because of this biological and prognostic importance in cutaneous melanoma, angiotropism was studied in uveal melanoma (UM). This retrospective study performed at a single ocular oncology referral center included 89 patients from the study period 2006-2008. All patients were diagnosed with UM from the choroid and/or ciliary body. All patients underwent enucleation for prognostic purposes and definitive therapy...
February 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28240686/sepsis-patients-display-a-reduced-capacity-to-activate-nuclear-factor-%C3%AE%C2%BAb-in-multiple-cell-types
#18
Arie J Hoogendijk, M Isabel Garcia-Laorden, Lonneke A van Vught, Maryse A Wiewel, Hakima Belkasim-Bohoudi, JanWillem Duitman, Janneke Horn, Marcus J Schultz, Brendon P Scicluna, Cornelis van 't Veer, Alex F de Vos, Tom van der Poll
OBJECTIVES: Sepsis is a complex clinical condition associated with high morbidity and mortality. A distinctive feature of sepsis is the reduced capacity of leukocytes to release proinflammatory cytokines in response to ex vivo stimulation. Cellular signaling events leading to immunosuppression in sepsis are not well defined. We investigated cell-specific signaling events underlying the immunosuppressed phenotype in sepsis. DESIGN: Ex vivo study. SETTING: ICU of an academic hospital...
February 24, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28240601/foxp1-controls-mesenchymal-stem-cell-commitment-and-senescence-during-skeletal-aging
#19
Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D Dekker, Baojie Li, Ying Fan, Zhenlin Zhang, Yang Hong, Gong Yang, Tingting Tang, Yongxin Ren, Haley O Tucker, Zhengju Yao, Xizhi Guo
A hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adipocyte coupled with a decrease in self-renewal capacity. However, how these cellular events are orchestrated in the aging progress is not fully understood. In this study, we have used molecular and genetic approaches to investigate the role of forkhead box P1 (FOXP1) in transcriptional control of MSC senescence. In bone marrow MSCs, FOXP1 expression levels declined with age in an inverse manner with those of the senescence marker p16INK4A...
February 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28240520/roles-of-signal-transducer-pathways-in-investigation-of-biopsies-from-patients-with-bladder-tumors
#20
Aysegul Bayrak, Sukru Palanduz, Ender Coskunpinar, Oner Sanli, Abdullah Armagan, Serkan Karakus, Ramazan Topaktas, Kivanc Cefle, Sukru Ozturk, Ali Ucur
Background:The process of development of bladder cancer features alteration of normal biological conditions caused by changes in molecular pathways. Removing control over regulation of these pathways could lead to changes in signal transduction and abnormal regulation of genes. During tumor formation and progression, genes regulate critical cellular processes, involved in cell cycling, growth and death. Here we evaluated the expression and prognostic importance of FGFR1, HRAS, CCND1, CCND3, STAT3 and FAS genes...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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