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placenta aging

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https://www.readbyqxmd.com/read/29331236/pregnancy-related-complications-and-perinatal-outcomes-resulting-from-transfer-of-cryopreserved-versus-fresh-embryos-in%C3%A2-vitro-fertilization-a-meta-analysis
#1
Tingting Sha, Xunqiang Yin, Wenwei Cheng, Isaac Yaw Massey
OBJECTIVE: To provide an updated comparison of pregnancy-related complications and adverse perinatal outcomes of pregnancies conceived after frozen embryo transfer (FET) versus fresh embryo transfer (fresh ET). DESIGN: Meta-analysis. SETTING: University. PATIENT(S): Pregnancies resulting from FET versus fresh ET. INTERVENTIONS(S): Pubmed, Embase, Cochrane Library, Google Scholar, and Chinese databases, including the China National Knowledge Infrastructure Database, Wanfang, and Chinese Scientific Journals Full-Text Database were searched by two independent reviewers from January 1980 to September 2017...
January 11, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29331157/eccentric-placentae-have-reduced-surface-area-and-are-associated-with-lower-birth-weight-in-babies-small-for-gestational-age
#2
G Ravikumar, J Crasta, J S Prabhu, T Thomas, P Dwarkanath, A Thomas, T S Sridhar, A V Kurpad
Placental structure and function determine birth outcomes. Placental mass does not always correlate with fetal birth weight (BW) in uncomplicated pregnancies which raises the possibility of other variables such as placental shape and cord insertion being the determinants of placental efficiency. In total, 160 women with singleton pregnancy, recruited into a pregnancy cohort were studied. Placental weight (PW) was measured and other data were obtained from clinical records. Birth outcomes were classified as small for gestational age (SGA) and appropriate for gestational age (AGA) based on fetal gender, gestational age (GA) and BW...
January 14, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29328396/placenta%C3%A2-associated-serum-exosomal-mir%C3%A2-155-derived-from-patients-with-preeclampsia-inhibits-enos-expression-in-human-umbilical-vein-endothelial-cells
#3
Li Shen, Yujing Li, Ruotian Li, Zhenyu Diao, Muyi Yany, Mengfei Wu, Haixiang Sun, Guijun Yan, Yali Hu
Preeclampsia (PE) is considered to be initiated by abnormal placentation in early pregnancy and results in systemic endothelial cell dysfunction in the second or third trimester. MicroRNAs (miRs) expressed in the human placenta can be secreted into maternal circulation via exosomes, which are secreted extracellular vesicles that serve important roles in intercellular communication. The present study hypothesized that upregulation of placenta‑associated serum exosomal miR‑155 from patients with PE may suppress endothelial nitric oxide synthase (eNOS) expression in endothelial cells...
January 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29324602/antecedents-of-abnormally-invasive-placenta-in-primiparous-women-risk-associated-with-gynecologic-procedures
#4
Heather J Baldwin, Jillian A Patterson, Tanya A Nippita, Siranda Torvaldsen, Ibinabo Ibiebele, Judy M Simpson, Jane B Ford
OBJECTIVE: To evaluate the association between prior invasive gynecologic procedures and the risk of subsequent abnormally invasive placenta (ie, placenta accreta, increta, and percreta). METHODS: We conducted a population-based data linkage study including all primiparous women who delivered in New South Wales, Australia, between 2003 and 2012. Data were obtained from linked birth and hospital admissions with a minimum lookback period of 2 years. Prior procedures invasive of the uterus were considered including gynecologic laparoscopy with instrumentation of the uterus; hysteroscopy, including operative hysteroscopy; curettage, including suction curettage and surgical termination; and endometrial ablation...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29320815/comparison-of-placenta-pcr-and-maternal-serology-of-aborted-women-for-detection-of-toxoplasma-gondii-in-ardabil-iran
#5
Somaie Matin, Gholamreza Shahbazi, Shervin Tabrizian Namin, Rouhallah Moradpour, Farideh Feizi, Hadi Piri-Dogahe
Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission of the parasite to the fetus. This study was conducted to test the utility of PCR assay to detect recent infections with Toxoplasma in aborted women at various gestational ages who referred to Obstetrics and Gynecology Department of Alavi Hospital in Ardabil during 2014 and 2016. Two hundred women with a history of single or repeated abortion were investigated in this study. Blood samples were tested for specific anti-Toxoplasma IgM and IgG antibodies by ELISA...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29313878/postpartum-ct-angiography-of-the-fetoplacental-macrovasculature-in-normal-pregnancies-and-in-those-complicated-by-fetal-growth-restriction
#6
Mette Østergaard Thunbo, Marianne Sinding, Anne Sofie Korsager, Jens Brøndum Frøkjaer, Lasse Riis Østergaard, Astrid Petersen, Charlotte Overgaard, Anne Sørensen
INTRODUCTION: Current knowledge of the fetoplacental vasculature in fetal growth restriction (FGR) due to placental dysfunction focuses on the microvasculature rather than the macrovasculature. The aim of this study was to investigate the feasibility of computed topography angiography to analyze the fetoplacental macrovasculature in normal and FGR pregnancies. MATERIAL AND METHODS: We included 29 placentas (22-42 weeks' gestation) from normal birthweight pregnancies and 8 placentas (26-37 weeks' gestation) from FGR pregnancies (birthweight < -15% and abnormal umbilical Doppler flow)...
January 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29305123/automated-visualization-and-quantification-of-spiral-artery-blood-flow-entering-the-first-trimester-placenta-using-3-d-power-doppler-ultrasound
#7
Gordon N Stevenson, J Alison Noble, Alec W Welsh, Lawrence Impey, Sally L Collins
The goal of our research was to quantify the placental vascularity in 3-D at 11-13 + 6 wk of pregnancy at precise distances from the utero-placental interface (UPI) using 3-D power Doppler ultrasound. With this automated image analysis technique, differences in vascularity between normal and pathologic pregnancies may be observed. The algorithm was validated using a computer-generated image phantom and applied retrospectively in 143 patients. The following features from the PD data were recorded: The number of spiral artery jets into the inter-villous space, total geometric and PD area...
January 2, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29298278/the-impact-of-air-pollution-to-central-nervous-system-in-children-and-adults
#8
Radim J Sram, Milos Veleminsky, Milos Veleminsky, Jana Stejskalová
The aim of this paper was to review studies analyzing the associations between air pollution and neurodevelopment in children as well as the effect on adult population. Effect of prenatal exposure to polycyclic aromatic hydrocarbons (PAHs, benzo[a]pyrene, B[a]P) were already studied on cohorts from New York, Poland, China, and Spain. All results indicate changes of child behavior and neurodevelopment at the age of 3-9 years, decrease of IQ, increase of Attention Deficit Hyperactivity Disorder (ADHD), decrease of brain-derived neurotrophic factor (BDNF), reduction of left hemisphere white matter...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29288976/maternal-parity-affects-placental-development-growth-and-metabolism-of-foals-until-1-year-and-a-half
#9
M Robles, C Dubois, C Gautier, M Dahirel, I Guenon, H Bouraima-Lelong, C Viguié, L Wimel, A Couturier-Tarrade, P Chavatte-Palmer
Primiparous mares are known to produce smaller foals than multiparous mares. This difference seems to be partly explained by the reduced exchange surface and volume of the placental villi in primiparous compared to multiparous placentas. The effect of maternal parity on foals' post-natal growth, metabolism and sexual maturation, however, has been given little consideration. The objectives of this work were to analyse placental biometry and structure at term, growth of foals and yearlings, their metabolism and testicular maturation at one year of age...
December 21, 2017: Theriogenology
https://www.readbyqxmd.com/read/29285226/parity-improves-anti-tumor-immunity-in-breast-cancer-patients
#10
Anna-Lena Krause, Florian Schuetz, Marc Boudewijns, Maria Pritsch, Markus Wallwiener, Michael Golatta, Joachim Rom, Joerg Heil, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove, Christoph Domschke
Compared to nulliparous women, parous women have an up to 50% lower lifetime risk of developing breast cancer. An endogenous mechanism to prevent the development of cancer is the destruction of tumor cells by T cells that recognize tumor-associated antigens (TAA). Since a number of TAA are also highly present in the breast and placenta of pregnant women, we investigated the induction and characteristics of spontaneous T cell responses against TAA during pregnancy. To this end, we collected peripheral blood from healthy nulliparous, primigravid and parous women, as well as from breast cancer patients...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281842/estimated-placental-volume-and-gestational-age
#11
Kimberly M M Isakov, John W Emerson, Katherine H Campbell, France Galerneau, Amber M Anders, Yoonjoo K Lee, Pritha Subramanyam, Andrea E Roberts, Harvey J Kliman
OBJECTIVE:  The objective of this study was to validate estimated placental volume (EPV) across a range of gestational ages (GAs). STUDY DESIGN:  Three hundred sixty-six patients from 2009 to 2011 received ultrasound scans between 11 + 0 and 38 + 6 weeks GA to assess EPV. An EPV versus GA best fit curve was generated and compared with published normative curves of EPV versus GA in a different population. A subanalysis was performed to explore the relationship between EPV and birth weight (BW)...
December 27, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29281153/microvascular-perfusion-of-the-placenta-developing-fetal-liver-and-lungs-assessed-with-intravoxel-incoherent-motion-imaging
#12
András Jakab, Ruth L Tuura, Raimund Kottke, Nicole Ochsenbein-Kölble, Giancarlo Natalucci, Thi Dao Nguyen, Christian Kellenberger, Ianina Scheer
BACKGROUND: In utero intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) provides a novel method for examining microvascular perfusion fraction and diffusion in the developing human fetus. PURPOSE: To characterize gestational changes in the microvascular perfusion fraction of the placenta, fetal liver, and lungs using IVIM-MRI. STUDY TYPE: Retrospective, cross-sectional study. SUBJECTS: Fifty-five datasets from 33 singleton pregnancies were acquired (17-36 gestational weeks)...
December 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29277277/new-imaging-markers-for-preconceptional-and-first-trimester-utero-placental-vascularization
#13
I F Reijnders, A G M G J Mulders, M P H Koster, A H J Koning, A Frudiger, S P Willemsen, E Jauniaux, G J Burton, R P M Steegers-Theunissen, E A P Steegers
INTRODUCTION: The availability of imaging makers of early placental circulation development is limited. This study aims to develop a feasible and reliable method to assess preconceptional and early first-trimester utero-placental vascular volumes using three-dimensional power Doppler (3D PD) ultrasound on two different Virtual Reality (VR) systems. METHODS: 3D PD ultrasound images of the uterine and placental vasculature were obtained in 35 women, either preconceptionally (n = 5), or during pregnancy at 7 (n = 10), 9 (n = 10) or 11 (n = 10) weeks of gestation...
January 2018: Placenta
https://www.readbyqxmd.com/read/29277274/maternal-high-estradiol-exposure-alters-cdkn1c-and-igf2-expression-in-human-placenta
#14
Xi-Jing Chen, Feng Chen, Ping-Ping Lv, Dan Zhang, Guo-Lian Ding, Xiao-Ling Hu, Chun Feng, Jian-Zhong Sheng, He-Feng Huang
INTRODUCTION: The increased maternal estradiol (E2) concentrations induced by assisted reproductive technology (ART) result in lower birth weight of offspring, which is associated with increased risk of adult diseases. However, the exact mechanism remains unknown. The present study investigated the effect of high E2 exposure on the expression of imprinted genes CDKN1C and IGF2 in human placentas and the DNA methylation status of their differential methylation regions (DMRs). METHODS: The mRNA expression of CDKN1C and IGF2 in human placentas and the human trophoblast cells (HTR8) treated with E2 were investigated by reverse transcription-real time polymerase chain reaction (PCR)...
January 2018: Placenta
https://www.readbyqxmd.com/read/29276874/persistent-hyperglycemia-in-a-neonate-is-it-a-complication-of-therapeutic-hypothermia
#15
Hülya Özdemir, Aslı Memişoğlu, Zeynep Alp-Unkar, Baran Arcagök, Hülya Bilgen, Serap Turan, Eren Özek
Özdemir H, Memişoğlu A, Alp-Unkar Z, Arcagök B, Bilgen H, Turan S, Özek E. Persistent hyperglycemia in a neonate: Is it a complication of therapeutic hypothermia? Turk J Pediatr 2017; 59: 193-196. The aim of this report is to present a newborn with persistent hyperglycemia requiring insulin therapy as a possible complication of therapeutic hypothermia. A term appropriate for gestational age (AGA) female infant, was born by emergency cesarean section due to abruption of placenta and was resuscitated and intubated in the delivery room...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29275823/is-there-a-role-for-placental-senescence-in-the-genesis-of-obstetric-complications-and-fetal-growth-restriction
#16
REVIEW
Zakia Sultana, Kaushik Maiti, Lee Dedman, Roger Smith
The placenta ages as pregnancy advances, yet its continued function is required for a successful pregnancy outcome. Placental aging is a physiological phenomenon; however, there are some placentas that show signs of aging earlier than others. Premature placental senescence and aging are implicated in a number of adverse pregnancy outcomes, including fetal growth restriction, preeclampsia, spontaneous preterm birth, and intrauterine fetal death. Here we discuss cellular senescence, a state of terminal proliferation arrest, and how senescence is regulated...
December 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29274251/quantitative-flow-imaging-in-human-umbilical-vessels-in-utero-using-nongated-2d-phase-contrast-mri
#17
Uday Krishnamurthy, Brijesh K Yadav, Pavan K Jella, Ewart Mark Haacke, Edgar Hernandez-Andrade, Swati Mody, Lami Yeo, Sonia S Hassan, Roberto Romero, Jaladhar Neelavalli
BACKGROUND: Volumetric assessment of afferent blood flow rate provides a measure of global organ perfusion. Phase-contrast magnetic resonance imaging (PCMRI) is a reliable tool for volumetric flow quantification, but given the challenges with motion and lack of physiologic gating signal, such studies, in vivo on the human placenta, are scant. PURPOSE: To evaluate and apply a nongated (ng) PCMRI technique for quantifying blood flow rates in utero in umbilical vessels...
December 23, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29260534/-risk-factors-for-blood-transfusion-in-women-with-postpartum-hemorrhage-a-case-control-study
#18
Shu-Ying Li, Meng Chen, Guo-Lin He, Lei He, Qiang Wei, Tao Li, Xing-Hui Liu
OBJECTIVE: To investigate the risk factors for increased red blood cells (RBCs) transfusion ratio in the women with postpartum hemorrhage (PPH). METHODS: This case-control study obtained the inpatient medical records of 112 441 pregnant women from 37 hospitals in 2011. There were 4 131 women diagnosed with PPH,record data of those patients were analyzed,including basic characteristics of patients,the level of hospital,pregnancy related complications,prenatal hemoglobin (Hb),mode of delivery,details of postpartum blood loss and blood transfusion,and maternal and neonatal outcomes...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29251202/cd15-as-a-marker-of-fetoplacental-endothelial-immaturity-in-iugr-placentas
#19
Gayatri Ravikumar, Julian Crasta, Jyothi S Prabhu, Tinku Thomas, Pratibha Dwarkanath, Annamma Thomas, Anura V Kurpad, Tirumalai Srinivas Sridhar
BACKGROUND: Structural or functional defects in the placenta, are the primary cause of growth restriction of the fetus. Morphological examination of such placentas from intrauterine growth restricted (IUGR) fetuses often appears deceptively normal. Evaluation of angiogenesis and fetoplacental vasculature is critical to understand the underlying pathogenesis of fetal growth restriction in both idiopathic as well as cases where it is thought to be secondary to complications like preeclampsia (PE)...
December 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29250999/pesticides-exposure-through-environment-and-risk-of-pre-term-birth-a-study-from-agra-city
#20
M Anand, L Singh, P Agarwal, R Saroj, A Taneja
Pre-term birth is an increasingly prevalent complex condition with multiple risk factors including environmental pollutants. Evidences linking organochlorine pesticides with adverse pregnancy outcomes are inconsistent for link between organochlorine pesticides and adverse pregnancy outcomes. We performed a case-control study of 50 cases of full-term births and 40 cases of pre-term births in this study. Placental organochlorine pesticides like metabolites of dichlorodiphenyltrichloroethane that is, (p,p-DDE, p,p-DDT and o,p-DDD) and isomers of hexachlorocyclohexane (α, β, γ and δ HCH) were analyzed by gas chromatography...
December 18, 2017: Drug and Chemical Toxicology
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