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placenta aging

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https://www.readbyqxmd.com/read/28922541/effects-of-collagen-peptides-intake-on-skin-ageing-and-platelet-release-in-chronologically-aged-mice-revealed-by-cytokine-array-analysis
#1
Hongdong Song, Ling Zhang, Yongkang Luo, Siqi Zhang, Bo Li
Action mechanisms underlying various biological activities of collagen peptides (CPs) remained to be elucidated. Cytokines may play an important role in mediating these health benefits of CPs. This study aimed to systemically examine the cytokines in skin and blood regulated by CPs intake. Thirteen-month-old female Kunming mice were administered with CPs for 2 months (0 or 400 mg/kg bodyweight/day). The cytokines in skin and plasma were analysed using a 53-cytokine array and corresponding ELISA kits. In skin, CPs intake significantly down-regulated placenta growth factor (PIGF-2), insulin-like growth factor (IGF)-binding protein (IGFBP) -2 and IGFBP-3, and up-regulated platelet factor 4 (PF4), serpin E1 and transforming growth factor (TGF)-β1 ...
September 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28919681/seroprevalence-of-bovine-viral-diarrhea-virus-in-crossbred-dairy-cattle-in-bangladesh
#2
Mohammed Arif Uddin, A S M Lutful Ahasan, Kamrul Islam, Md Zohorul Islam, Altaf Mahmood, Ariful Islam, Kazi Muhammad Fakhrul Islam, Abdul Ahad
AIM: The study was conducted to determine the seroprevalence of bovine viral diarrhea virus (BVDV) and hematological features in crossbred dairy cattle in Chittagong, Bangladesh. MATERIALS AND METHODS: The antibody against BVDV in crossbred dairy cattle serum was detected by indirect enzyme-linked immunosorbent assay. The association of different categorical variables in the prevalence of BVDV has been studied. Blood samples were collected and analyzed to know the hematological variations in the study population...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28913590/challenges-of-anticoagulation-therapy-in-pregnancy
#3
REVIEW
Annemarie E Fogerty
Thrombotic complications in pregnancy represent a major cause of morbidity and mortality. Pregnancy is a primary hypercoagulable state due to enhanced production of clotting factors, a decrease in protein S activity, and inhibition of fibrinolysis. These physiologic changes will yield a collective rate of venous thromboembolism (VTE) of about 1-2 in 1000 pregnancies for the general obstetric population, which represents a five- to tenfold increased risk in pregnancy compared to age-matched non-pregnant peers...
September 14, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28910963/placental-transfer-of-persistent-organic-pollutants-and-feasibility-using-the-placenta-as-a-non-invasive-biomonitoring-matrix
#4
Yunsun Jeong, Sunggyu Lee, Sunmi Kim, Jeongim Park, Hai-Joong Kim, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Sungkyoon Kim, Kyungho Choi, Hyo-Bang Moon
The placenta is a crucial organ for the supply of oxygen and nutritional elements from mother to fetus. Several studies have reported evidence of the placental transfer of persistent organic pollutants (POPs). Despite the importance of prenatal exposure to POPs, the transport process of POPs via the human placenta is not well understood. To investigate the transport processes of these contaminants and to assess the feasibility of the placenta as a non-invasive biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) in placenta tissues...
September 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28903888/serum-angiogenic-and-anti-angiogenic-markers-in-pregnant-women-with-placenta-percreta
#5
Hacer Uyanıkoğlu, Adnan İncebıyık, Ahmet B Turp, Güler Çakmak, Sibel Sak, Neşe G Hilali
BACKGROUNDS: Placenta percreta (PP) is the morbidly adherent form of placental invasion abnormalities. The pathology that underlies the PP is poorly understood. AIMS: To compare the levels of circulating vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble fms like tyrosine kinase 1 (sFlt-1) in pregnant women with PP and control group. STUDY DESIGN: Case-control study. METHODS: Twenty two women who underwent cesarean section (CS) due to PP and 22 women who underwent CS for other obstetric reasons were included in this study...
September 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28898871/placental-component-and-pregnancy-outcome-in-singleton-versus-twin-pregnancies-complicated-by-preeclampsia
#6
Eran Weiner, Ohad Feldstein, Letizia Schreiber, Ehud Grinstein, Elad Barber, Ann Dekalo, Jacob Bar, Michal Kovo
OBJECTIVE: To compare placental histopathological lesions and pregnancy outcomes in singleton and twin pregnancies complicated by preeclampsia (PE). METHODS: Maternal characteristics, neonatal outcomes, and placental histopathology reports of pregnancies complicated by PE between January 2008 and October 2016 were reviewed. Results were compared between singletons (singleton group) and dichorionic-diamniotic twins (twin group). Placental lesions were classified into maternal and fetal vascular supply lesions...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28893211/clinical-performance-and-patient-outcome-after-simulation-based-training-in-prevention-and-management-of-postpartum-haemorrhage-an-educational-intervention-study-in-a-low-resource-setting
#7
Ellen Nelissen, Hege Ersdal, Estomih Mduma, Bjørg Evjen-Olsen, Jos Twisk, Jacqueline Broerse, Jos van Roosmalen, Jelle Stekelenburg
BACKGROUND: Postpartum haemorrhage (PPH) is a major cause of maternal mortality. Prevention and adequate treatment are therefore important. However, most births in low-resource settings are not attended by skilled providers, and knowledge and skills of healthcare workers that are available are low. Simulation-based training effectively improves knowledge and simulated skills, but the effectiveness of training on clinical behaviour and patient outcome is not yet fully understood. The aim of this study was to assess the effect of obstetric simulation-based training on the incidence of PPH and clinical performance of basic delivery skills and management of PPH...
September 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28885411/improvement-in-outcomes-of-major-obstetric-hemorrhage-through-systematic-change
#8
Daniel W Skupski, David Brady, Isaac P Lowenwirt, Jason Sample, Stephanie N Lin, Rahul Lohana, Gary S Eglinton
OBJECTIVE: To report the outcomes over 14 years of sustained systematic institutional focus on the care of women with major obstetric hemorrhage, defined as estimated blood loss greater than 1,500 mL. METHODS: A retrospective cohort study of women with major obstetric hemorrhage at our hospital from 2000 to 2014 compares baseline conditions (age, multiparity, prior cesarean delivery, morbidly adherent placenta), morbidity (lowest mean temperature, lowest mean pH, coagulopathy, hysterectomy), and mortality among three time periods (period 1=January 2000 to December 2001, period 2=January 2002 to August 2005, period 3=September 2005 to December 2014)...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28878092/equine-fetal-adrenal-gonadal-and-placental-steroidogenesis
#9
Erin L Legacki, Barry A Ball, C Jo Corbin, Shavahn C Loux, Kirsten E Scoggin, Scott D Stanley, Alan J Conley
Equine fetuses have substantial circulating pregnenolone concentrations and thus have been postulated to provide significant substrate for placental 5α-reduced pregnane production, but the fetal site of pregnenolone synthesis remains unclear. The current studies investigated steroid concentrations in blood, adrenal glands, gonads and placenta from fetuses (4, 6, 9 and 10 months of gestational age (GA)), as well as tissue steroidogenic enzyme transcript levels. Pregnenolone and dehydroepiandrosterone (DHEA) were the most abundant steroids in fetal blood, pregnenolone was consistently higher but decreased progressively with GA...
October 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28874260/endometriosis-and-obstetrics-complications-a-systematic-review-and-meta-analysis
#10
Fabrizio Zullo, Emanuela Spagnolo, Gabriele Saccone, Miriam Acunzo, Serena Xodo, Marcello Ceccaroni, Vincenzo Berghella
OBJECTIVE: To evaluate the effect of endometriosis on pregnancy outcomes. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Women with or without endometriosis. INTERVENTION(S): Electronic databases searched from their inception until February 2017 with no limit for language and with all cohort studies reporting the incidence of obstetric complications in women with a diagnosis of endometriosis compared with a control group (women without a diagnosis of endometriosis) included...
September 2, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28871576/first-trimester-combined-screening-for-preeclampsia-and-small-for-gestational-age-a-single-centre-experience-and-validation-of-the-fmf-screening-algorithm
#11
Beatrice Mosimann, Chantal Pfiffner, Sofia Amylidi-Mohr, Lorenz Risch, Daniel Surbek, Luigi Raio
AIM OF THE STUDY: Preeclampsia (PE) is associated with severe maternal and fetal morbidity in the acute presentation and there is increasing evidence that it is also an important risk factor for cardiovascular disease later in life. Therefore, preventive strategies are of utmost importance. The Fetal Medicine Foundation (FMF) London recently developed a first trimester screening algorithm for placenta-related pregnancy complications, in particular early onset preeclampsia (eoPE) requiring delivery before 34 weeks, and preterm small for gestational age (pSGA), with a birth weight <5th percentile and delivery before 37 weeks of gestation, based on maternal history and characteristics, and biochemical and biophysical parameters...
September 5, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28865850/validation-of-genomic-predictions-for-wellness-traits-in-us-holstein-cows
#12
Anthony K McNeel, Brenda C Reiter, Dan Weigel, Jason Osterstock, Fernando A Di Croce
The objective of this study was to evaluate the efficacy of wellness trait genetic predictions in commercial herds of US Holstein cows from herds that do not contribute phenotypic information to the evaluation. Tissue samples for DNA extraction were collected from more than 3,400 randomly selected pregnant Holstein females in 11 herds and 2 age groups (69% nulliparous, 31% primiparous) approximately 30 to 60 d before their expected calving date. Lactation records from cows that calved between September 1, 2015, and December 31, 2015, were included in the analysis...
August 30, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28864983/epigenetic-influences-during-the-periconception-period-and-assisted-reproduction
#13
Akwasi A Amoako, Tamer M Nafee, Bolarinde Ola
The periconception period starts 6 months before conception and lasts until the tenth week of gestation. In this chapter, we will focus on epigenetic modifications to DNA and gene expression within this period and during assisted reproduction. There are two critical times during the periconception window when significant epigenetic 'reprogramming' occur: one during gametogenesis and another during the pre-implantation embryonic stage. Furthermore, assisted conception treatments, laboratory protocols and culture media can affect the embryo development and birth weights in laboratory animals...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28864965/pharmacological-management-of-gestational-diabetes-mellitus
#14
Geetha Mukerji, Denice S Feig
Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse pregnancy outcomes in the setting of poor glycemic control. The initial management for GDM includes intensive lifestyle modification, which often requires behavioral and nutritional changes to optimize glycemic control. Pharmacotherapy for GDM is initiated when glycemic targets are not met. The rapid-acting bolus analogues aspart and lispro achieve postprandial targets with less hypoglycemia compared to regular insulin, with similar fetal outcomes...
September 2, 2017: Drugs
https://www.readbyqxmd.com/read/28864025/birth-weight-umbilical-and-placental-traits-in-relation-to-neonatal-loss-in-cloned-pigs
#15
Zheng Ao, Dewu Liu, Chengfa Zhao, Zhimin Yue, Junsong Shi, Rong Zhou, Gengyuan Cai, Enqin Zheng, Zicong Li, Zhenfang Wu
Cloned piglets generated through somatic cell nuclear transfer (SCNT) have a high rate of neonatal death. Postnatal loss is associated with low birth weight, umbilical status and placental parameters in fertilisation-derived piglets. To investigate whether or not this relationship also exists in cloned piglets, birth weight, umbilical status, placental parameters, placental morphology and gene expression pattern were compared among four piglet groups, namely, SCNT-derived male piglets that died within 4 days (SCNT-DW4), SCNT-derived male piglets that survived over 4 days (SCNT-SO4), artificial insemination (AI)-generated male piglets that died within 4 days (AI-DW4) and AI-generated male piglets that survived over 4 days (AI-SO4)...
September 2017: Placenta
https://www.readbyqxmd.com/read/28864010/the-association-between-placental-histopathology-and-autism-spectrum-disorder
#16
Jennifer K Straughen, Dawn P Misra, George Divine, Ruchit Shah, Gabriela Perez, Samantha VanHorn, Victoria Onbreyt, Beata Dygulska, Rebecca Schmitt, Sanford Lederman, Pramod Narula, Carolyn M Salafia
INTRODUCTION: Research suggests that autism spectrum disorder (ASD) has its origins in utero. This study examines the association between evidence of placental histopathology and ASD. METHODS: Administrative claims data and medical records data were used to identify ASD cases (N = 55) and matched controls (N = 199) born at New York Methodist Hospital between 2007 and 2014 and subsequently seen in affiliated pediatrics clinics. Placentas from all births during this time period were reviewed as part of routine care...
September 2017: Placenta
https://www.readbyqxmd.com/read/28864000/first-trimester-placental-thickness-and-the-risk-of-preeclampsia-or-sga
#17
Chantale Vachon-Marceau, Suzanne Demers, Stéphanie Markey, Nan Okun, Mario Girard, John Kingdom, Emmanuel Bujold
INTRODUCTION: Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestational-age (SGA) neonate. METHODS: Prospective cohort study of women recruited at 11-14 weeks gestation. Placental thickness was measured at its apparent center and reported in multiple of median (MoM) adjusted for gestational age...
September 2017: Placenta
https://www.readbyqxmd.com/read/28862023/what-is-the-most-suitable-mr-signal-index-for-quantitative-evaluation-of-placental-function-using-half-fourier-acquisition-single-shot-turbo-spin-echo-compared-with-t2-relaxation-time
#18
Kyoko Nakao Kameyama, Aki Kido, Yuki Himoto, Yusaku Moribata, Sachiko Minamiguchi, Ikuo Konishi, Kaori Togashi
Background Half-Fourier acquisition single-shot turbo spin-echo (HASTE) imaging is now widely used for placental and fetal imaging because of its rapidity and low sensitivity to fetal movement. If placental dysfunction is also predicted by quantitative value obtained from HASTE image, then it might be beneficial for evaluating placental wellbeing. Purpose To ascertain the most suitable magnetic resonance (MR) signal indexes reflecting placental function using HASTE imaging. Material and Methods This retrospective study included 37 consequent patients who had given informed consent to MR imaging (MRI) examinations...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28852057/placental-dysfunction-underlies-increased-risk-of-fetal-growth-restriction-and-stillbirth-in-advanced-maternal-age-women
#19
Samantha C Lean, Alexander E P Heazell, Mark R Dilworth, Tracey A Mills, Rebecca L Jones
Pregnancies in women of advanced maternal age (AMA) are susceptible to fetal growth restriction (FGR) and stillbirth. We hypothesised that maternal ageing is associated with utero-placental dysfunction, predisposing to adverse fetal outcomes. Women of AMA (≥35 years) and young controls (20-30 years) with uncomplicated pregnancies were studied. Placentas from AMA women exhibited increased syncytial nuclear aggregates and decreased proliferation, and had increased amino acid transporter activity. Chorionic plate and myometrial artery relaxation was increased compared to controls...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846666/interleukin-6-il-6-and-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-single-nucleotide-polymorphisms-snps-inflammation-and-metabolism-in-gestational-diabetes-mellitus-in-inner-mongolia
#20
Jie Zhang, Haiyi Chi, Huiying Xiao, Xiaoyan Tian, Yilin Wang, Xia Yun, Yancheng Xu
BACKGROUND Gestational diabetes mellitus (GDM) is common all over the world. GDM women are with inflammatory and metabolisms abnormalities. However, few studies have focused on the association of IL-65-72C/G and TNF-α -857C/T single nucleotide polymorphisms (SNPs), inflammatory biomarkers, and metabolic indexes in women with GDM, especially in the Inner Mongolia population. The aim of this study was to investigate the associations of IL-65-72C/G and TNF-α -857C/T SNPs, and inflammation and metabolic biomarkers in women with GDM pregnancies...
August 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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