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https://www.readbyqxmd.com/read/29340600/development-and-impact-of-a-massive-open-online-course-mooc-for-antimicrobial-stewardship
#1
Jacqueline Sneddon, Gavin Barlow, Sally Bradley, Adrian Brink, Sujith J Chandy, Dilip Nathwani
Background: The University of Dundee and the BSAC developed a massive open online course (MOOC) to address the global need for education to support antimicrobial stewardship in low- and middle-income countries. Methods: An interactive course, Antimicrobial Stewardship: Managing Antibiotic Resistance, was developed and delivered via the FutureLearn© platform. The course ran over four 6 week periods during 2015 and 2016 supported by educators and was evaluated via data on uptake and feedback from learners on impact on clinical practice...
January 10, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29338025/adolescent-cohorts-assessing-growth-cardiovascular-and-cognitive-outcomes-in-low-and-middle-income-countries
#2
Joseph L Ward, Katherine Harrison, Russell M Viner, Anthony Costello, Michelle Heys
INTRODUCTION: Life-course studies are needed to explore how exposures during adolescence, particularly puberty, contribute to later cardiovascular risk and cognitive health in low and middle-income countries (LMIC), where 90% of the world's young people live. The extent of any existing cohorts investigating these outcomes in LMIC has not previously been described. METHODS: We performed a systematic literature review to identify population cohort studies of adolescents in LMIC that assessed anthropometry and any of cardiovascular risk (blood pressure, physical activity, plasma glucose/lipid profile and substance misuse), puberty (age at menarche, Tanner staging, or other form of pubertal staging) or cognitive outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29334944/changes-in-malaria-epidemiology-in-germany-2001-2016-a-time-series-analysis
#3
Sabine Vygen-Bonnet, Klaus Stark
BACKGROUND: German surveillance data showed a sharp rise of malaria cases in 2014 and 2015 due to the increased arrival of refugees from malaria endemic countries. A time series analysis of data from 2001 to 2016 was performed in order to describe the epidemiology of imported malaria in Germany in general and of the recent increase in particular. RESULTS: In total, 11,678 malaria cases were notified between 2001 and 2016 (range 526-1063 cases/year). Newly arriving refugees averaged 10 cases/year (1...
January 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29333149/a-summary-of-worldwide-national-activities-in-chronic-kidney-disease-ckd-testing
#4
Roberto Ruiz-Arenas, Rosa Sierra-Amor, David Seccombe, Stella Raymondo, Maria Stella Graziani, Mauro Panteghini, Tewogbade A Adedeji, Shanthi Naidu Kamatham, Vanja Radišić Biljak
Chronic kidney disease (CKD) is a major public health issue worldwide and is associated with adverse health outcomes, especially in low- and middle-income countries. In a cash limited healthcare system, guidelines that improve the efficiency of health care free up resources needed for other healthcare services. This short review presents some examples from national acitivities in CKD testing, including countries throughout the globe: Mexico in North America, Uruguay in South America, Italy in Europe, Nigeria in Africa and India in Asia...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29332634/reports-of-wheezing-and-of-diagnosed-asthma-are-associated-with-impaired-social-functioning-secondary-analysis-of-the-cross-sectional-world-health-survey-data
#5
Adrian Loerbroks, Jos A Bosch, Aziz Sheikh, Shelby Yamamoto, Raphael M Herr
OBJECTIVE: We sought to investigate whether there are associations between asthma and social functioning in adults from Western and non-Western countries. METHODS: We analyzed data on individuals (94% aged 20+, 52% female) from 50 countries participating in the cross-sectional World Health Survey. We used information on self-reports of wheezing and an asthma diagnosis. Social functioning was defined by reports of severe or extreme difficulties related to personal relationships or participation in the community...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29327947/secnidazole-next-generation-antimicrobial-agent-for-bacterial-vaginosis-treatment
#6
Paul Nyirjesy, Jane R Schwebke
Secnidazole is a next-generation 5-nitroimidazole approved for more than three decades in Europe, Asia, South America and Africa and recently in the USA as a single-dose (2 g) treatment of bacterial vaginosis (BV). Secnidazole is characterized by potent in vitro antimicrobial activity against BV-associated pathogens, as well as prolonged terminal elimination half-life and systemic exposure. These characteristics form the basis of effective and safe treatment of BV with a 2-g single-dose secnidazole regimen, which was recently confirmed in double-blind, placebo-controlled clinical trials conducted in the USA...
January 12, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29325943/neurosurgical-care-availability-and-access-in-low-and-middle-income-countries
#7
Maria Punchak, Swagoto Mukhopadhyay, Sonal Sachdev, Ya-Ching Hung, Sophie Peeters, Abbas Rattani, Michael Dewan, Walter D Johnson, Kee B Park
BACKGROUND: An estimated 5 billion people worldwide lack access to basic surgical care. In particular, the vast majority of low- and middle-income countries (LMICs) currently struggle to provide adequate neurosurgical services. Significant barriers exist, including limited access to trained medical, nursing and allied health staff, lack of equipment, and availability of services at reasonable distance and at reasonable cost to patients. An accurate assessment of current neurosurgical capacity in LIMCs is an essential first step in tackling this deficit...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325554/an-analysis-of-the-global-pharmacy-workforce-capacity-trends-from-2006-to-2012
#8
Ian Bates, Christopher John, Priyanka Seegobin, Andreia Bruno
BACKGROUND: Human resources for health are at a critical low. The World Health Organization estimates that the current shortage of health workers, including pharmacists, is in excess of 7.2 million worldwide and that, by 2035, the shortage will reach 12.9 million. Pharmacists, in particular, are lacking in the workforce in many countries. The International Pharmaceutical Federation (FIP) and academic partners have conducted periodic global pharmacy workforce surveys in 2006, 2009 and 2012 which have monitored and reported on the status of the pharmacy workforce at the country and territory levels...
January 11, 2018: Human Resources for Health
https://www.readbyqxmd.com/read/29323294/terminal-pleistocene-alaskan-genome-reveals-first-founding-population-of-native-americans
#9
J Víctor Moreno-Mayar, Ben A Potter, Lasse Vinner, Matthias Steinrücken, Simon Rasmussen, Jonathan Terhorst, John A Kamm, Anders Albrechtsen, Anna-Sapfo Malaspinas, Martin Sikora, Joshua D Reuther, Joel D Irish, Ripan S Malhi, Ludovic Orlando, Yun S Song, Rasmus Nielsen, David J Meltzer, Eske Willerslev
Despite broad agreement that the Americas were initially populated via Beringia, the land bridge that connected far northeast Asia with northwestern North America during the Pleistocene epoch, when and how the peopling of the Americas occurred remains unresolved. Analyses of human remains from Late Pleistocene Alaska are important to resolving the timing and dispersal of these populations. The remains of two infants were recovered at Upward Sun River (USR), and have been dated to around 11.5 thousand years ago (ka)...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29322642/peste-des-petits-ruminants-in-china-since-its-first-outbreak-in-2007-a-10-year-review
#10
REVIEW
F Liu, J Li, L Li, Y Liu, X Wu, Z Wang
Peste des petits ruminants (PPR) is a highly infectious disease of small ruminants and caused by small ruminant morbillivirus (SRMV), formerly called peste-des-petits-ruminants virus (PPRV). This disease is circulating in Africa (except most countries in southern Africa), the Arabian Peninsula, the Middle East, and Central, East and South-East Asia. Peste des petits ruminants is still regarded as an exotic disease in China, where its first outbreak was reported in the Ngari region of Tibet in 2007, but effectively controlled by slaughter, vaccination and animal movement restriction in PPR-infected areas...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29321868/global-mtdna-genetic-structure-and-hypothesized-invasion-history-of-a-major-pest-of-citrus-diaphorina-citri-hemiptera-liviidae
#11
Yufa Luo, Ingi Agnarsson
The Asian citrus psyllid Diaphorina citri Kuwayama is a key pest of citrus as the vector of the bacterium causing the "huanglongbing" disease (HLB). To assess the global mtDNA population genetic structure, and possible dispersal history of the pest, we investigated genetic variation at the COI gene collating newly collected samples with all previously published data. Our dataset consists of 356 colonies from 106 geographic sites worldwide. High haplotype diversity (H-mean = 0.702 ± 0.017), low nucleotide diversity (π-mean = 0...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29320572/international-migration-patterns-of-red-throated-loons-gavia-stellata-from-four-breeding-populations-in-alaska
#12
Sarah E McCloskey, Brian D Uher-Koch, Joel A Schmutz, Thomas F Fondell
Identifying post-breeding migration and wintering distributions of migratory birds is important for understanding factors that may drive population dynamics. Red-throated Loons (Gavia stellata) are widely distributed across Alaska and currently have varying population trends, including some populations with recent periods of decline. To investigate population differentiation and the location of migration pathways and wintering areas, which may inform population trend patterns, we used satellite transmitters (n = 32) to describe migration patterns of four geographically separate breeding populations of Red-throated Loons in Alaska...
2018: PloS One
https://www.readbyqxmd.com/read/29318332/-zika-virus-infection-and-the-nervous-system
#13
REVIEW
I W Husstedt, M Maschke, C Eggers, E Neuen-Jacob, G Arendt
Zika virus is an arbovirus from the family of flaviviruses, which is transmitted by the mosquito Aedes aegyptii and also by the Asian mosquito Aedes albopticus. The largest observed Zika virus epidemic is currently taking place in North and South America, in the Caribbean, southern USA and Southeast Asia. In most cases the infection is an unspecific, acute, febrile disease. Neurological manifestations consist mainly of microcephaly in newborns and Guillain-Barré syndrome but other rare manifestations have also become known in the meantime, such as meningoencephalitis and myelitis...
January 9, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29316694/blood-lead-levels-and-risk-factors-for-lead-exposure-in-a-pediatric-population-in-ho-chi-minh-city-vietnam
#14
Deborah Havens, Minh Hong Pham, Catherine J Karr, William E Daniell
Although lead recycling activities are a known risk factor for elevated blood levels in South East Asia, little is known regarding the prevalence of and risk factors for elevated blood lead levels (BLL) among the general pediatric population in Vietnam. This study is a cross-sectional evaluation of 311 children from Children's Hospital #2 in Ho Chi Minh City, Vietnam. Capillary blood lead testing was performed using the LeadCare II. Mean BLLs were 4.97 μg/dL (Standard Deviation (SD) 5.50), with 7% of the participants having levels greater than 10 μg/dL...
January 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29316293/estimating-radiotherapy-demands-in-south-east-asia-countries-in-2025-and-2035-using-evidence-based-optimal-radiotherapy-fractions
#15
Noorazrul Yahya, Nurhaziqah Roslan
BACKGROUND AND PURPOSE: As about 50% of cancer patients may require radiotherapy, the demand of radiotherapy as the main treatment to treat cancer is likely to rise due to rising cancer incidence. This study aims to quantify the radiotherapy demand in countries in Southeast Asia (SEA) in 2025 and 2035 using evidence-based optimal radiotherapy fractions. MATERIALS AND METHODS: SEA country-specific cancer incidence by tumor site for 2015, 2025 and 2035 was extracted from the GLOBOCAN database...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29316136/transrectal-prostate-biopsy-sepsis-rate-following-reduced-quinolone-antibiotic-prophylaxis-from-six-doses-to-single-dose
#16
Haider K Bangash, Cynthia Hawks, Steve P McCombie, Matthew Brown, Dickon Hayne
BACKGROUND: This study aimed to evaluate the rates of infective complication related to transrectal prostate biopsy (TRPB) as our centre changed its protocol from six doses over 3 days to a single pre-procedure prophylactic dose. METHODS: This prospective cohort study identified infective complication in patients who attended and subsequently underwent TRPB at the time of their one-stop prostate clinic at our public tertiary hospital between August 2011 and April 2017...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29304792/aberrant-use-and-poor-quality-of-trypanocides-a-risk-for-drug-resistance-in-south-western-ethiopia
#17
T Tekle, G Terefe, T Cherenet, H Ashenafi, K G Akoda, A Teko-Agbo, J Van Den Abbeele, G Gari, P-H Clausen, A Hoppenheit, R C Mattioli, R Peter, T Marcotty, G Cecchi, V Delespaux
BACKGROUND: Trypanocidal drugs have been used to control African animal trypanosomosis for several decades. In Ethiopia, these drugs are available from both authorized (legal) and unauthorized (illegal) sources but documentation on utilization practices and quality of circulating products is scanty. This study looked at the practices of trypanocidal drug utilization by farmers and the integrity of active ingredient in trypanocides sold in Gurage zone, south western Ethiopia. The surveys were based on a structured questionnaire and drug quality determination of commonly used brands originating from European and Asian companies and sold at both authorized and unauthorized markets...
January 5, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29302865/global-polio-eradication-way-ahead
#18
Sunil Bahl, Pankaj Bhatnagar, Roland W Sutter, Sigrun Roesel, Michel Zaffran
In 1988, the World Health Assembly resolved to eradicate poliomyelitis by the year 2000. Although substantial progress was achieved by 2000, global polio eradication proved elusive. In India, the goal was accomplished in 2011, and the entire South-East Asia Region was certified as polio-free in 2014. The year 2016 marks the lowest wild poliovirus type 1 case count ever, the lowest number of polio-endemic countries (Afghanistan, Nigeria and Pakistan), the maintenance of wild poliovirus type 2 eradication, and the continued absence of wild poliovirus type 3 detection since 2012...
January 5, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29299682/genetic-characterization-of-low-pathogenic-avian-influenza-viruses-isolated-on-the-izumi-plain-in-japan-possible-association-of-dynamic-movements-of-wild-birds-with-aiv-evolution
#19
Hiroko Nakagawa, Kosuke Okuya, Toshiko Kawabata, Aya Matsuu, Kozo Takase, Masakazu Kuwahara, Shigehisa Toda, Makoto Ozawa
The Izumi plain in Kagoshima Prefecture, Japan, is an overwintering site of endangered cranes (hooded cranes and white-naped cranes) and of many other migratory birds (including wild ducks) that are considered carriers of avian influenza viruses (AIVs). To assess the risks of a highly pathogenic avian influenza outbreak in the crane populations, we tested various environmental samples for AIVs in this area. In the 2014-2015 winter season, we isolated one AIV of the H6N2 subtype from the cranes' roost water and two AIVs of the H11N9 subtype from a crane fecal sample and a cloacal swab of a dead spot-billed duck...
January 3, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29297395/between-lake-baikal-and-the-baltic-sea-genomic-history-of-the-gateway-to-europe
#20
Petr Triska, Nikolay Chekanov, Vadim Stepanov, Elza K Khusnutdinova, Ganesh Prasad Arun Kumar, Vita Akhmetova, Konstantin Babalyan, Eugenia Boulygina, Vladimir Kharkov, Marina Gubina, Irina Khidiyatova, Irina Khitrinskaya, Ekaterina E Khrameeva, Rita Khusainova, Natalia Konovalova, Sergey Litvinov, Andrey Marusin, Alexandr M Mazur, Valery Puzyrev, Dinara Ivanoshchuk, Maria Spiridonova, Anton Teslyuk, Svetlana Tsygankova, Martin Triska, Natalya Trofimova, Edward Vajda, Oleg Balanovsky, Ancha Baranova, Konstantin Skryabin, Tatiana V Tatarinova, Egor Prokhortchouk
BACKGROUND: The history of human populations occupying the plains and mountain ridges separating Europe from Asia has been eventful, as these natural obstacles were crossed westward by multiple waves of Turkic and Uralic-speaking migrants as well as eastward by Europeans. Unfortunately, the material records of history of this region are not dense enough to reconstruct details of population history. These considerations stimulate growing interest to obtain a genetic picture of the demographic history of migrations and admixture in Northern Eurasia...
December 28, 2017: BMC Genetics
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