keyword
https://read.qxmd.com/read/38537186/can-the-width-of-lower-tongue-base-preoperative-sonography-measurements-predict-hypoxemia-during-esophagogastroduodenoscopy-under-sedation-in-asa-i-ii-patients
#1
JOURNAL ARTICLE
Hao Wu, Min Xia, Xu Chen, Sheng Wang, Wei Zhang
The most common complication during esophagogastroduodenoscopy (EGD) under sedation is hypoxemia. There is a scarcity of indicators to predict the risk of hypoxemia during EGD under sedation accurately. The width of the lower tongue base measured by ultrasound (US) is considered to be a significant predictor of the presence and severity of obstructive sleepapnea syndrome (OSAS), which develops hypoxemia by a similar mechanism to EGD under sedation. This study aimed to observe its ability to predict hypoxemia during EGD under sedation...
January 30, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38536888/barriers-and-benefits-of-online-group-exercise-programs-for-older-adults
#2
JOURNAL ARTICLE
Md Shafiqul Islam, Mary C Frazier, Samantha M Harden, Sol Lim
Engaging in regular physical activity offers a myriad of benefits, including the improvement of mental health, social well-being, and cognitive function. Unfortunately, obstacles, such as transportation constraints, time limitations, and inadequate exercise facilities, hinder the regular participation of older adults in physical activity. Online group physical activity programs present a promising solution to enhance the involvement of older adults; however, several barriers impede their effective utilization...
March 27, 2024: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/38536761/perspectives-on-the-impact-of-vortioxetine-on-the-treatment-armamentarium-of-major-depressive-disorder
#3
JOURNAL ARTICLE
Alessandro Cuomo, Giovanni Barillà, Matteo Cattolico, Simone Pardossi, Elisa Mariantoni, Despoina Koukouna, Pietro Carmellini, Andrea Fagiolini
INTRODUCTION: Major Depressive Disorder (MDD) is a mental health issue that significantly affects patients' quality of life and functioning. Despite available treatments, many patients continue to suffer due to incomplete symptom resolution and side effects. AREAS COVERED: This manuscript examines Vortioxetine's role in Major Depressive Disorder (MDD) treatment, highlighting its potential to reshape therapeutic strategies due to its unique Multimodal action and proven broad-spectrum efficacy in multiple depressive domains...
March 27, 2024: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/38536627/fatal-intoxications-with-zopiclone-a-cause-for-concern
#4
JOURNAL ARTICLE
Lova Tralla, Sara Gustavsson, Carl Söderberg, Anna K Jönsson, Fredrik C Kugelberg
INTRODUCTION: Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. METHODS: All forensic autopsy cases positive for zopiclone in femoral blood during 2012-2020 were selected. Among these cases, fatalities caused by intoxication according to the cause of death certificates issued by the forensic pathologist were identified...
March 27, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38536526/pharmacological-and-immunomodulatory-modes-of-action-of-medically-important-phytochemicals-against-arthritis-a-molecular-insight
#5
REVIEW
Aqsa, Shaukat Ali, Muhammad Summer, Saima Yousaf, Laiba Nazakat, Shehzeen Noor
Arthritis is a common illness that affects joints and it may result in inflammation and pain. Even though arthritis usually affects older people, it can also affect children, adults, and both genders. Numerous arthritic mouse models have been developed but the CIA model of rheumatoid arthritis (RA) has received the most attention. With the use of steroids, DMARDs, and NSAIDs, therapy objectives such as reduced disease incidence and better pain management are achieved. Long-term usage of these therapeutic approaches may have negative side effects...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536227/patient-education-and-decision-support-for-long-acting-injectable-hiv-antiretroviral-therapy-protocol-for-tool-development-and-pilot-testing-with-ryan-white-hiv-aids-program-medical-case-management-programs-in-new-york
#6
JOURNAL ARTICLE
Mary Kathryn Irvine, Rebecca Zimba, Tigran Avoundjian, Meghan Peterson, Connor Emmert, Sarah G Kulkarni, Morgan M Philbin, Elizabeth A Kelvin, Denis Nash
BACKGROUND: Long-acting injectable (LAI) HIV antiretroviral therapy (ART) presents a major opportunity to facilitate and sustain HIV viral suppression, thus improving health and survival among people living with HIV and reducing the risk of onward transmission. However, realizing the public health potential of LAI ART requires reaching patients who face barriers to daily oral ART adherence and thus can clinically benefit from alternative treatment modalities. Ryan White HIV/AIDS Program Part A medical case management (MCM) programs provide an array of services to address barriers to HIV care and treatment among economically and socially marginalized people living with HIV...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536212/interphase-engineering-via-solvent-molecule-chemistry-for-stable-lithium-metal-batteries
#7
JOURNAL ARTICLE
Jiahang Chen, Huichao Lu, Xirui Kong, Jian Liu, Jiqiong Liu, Jun Yang, Yanna Nuli, Jiulin Wang
Lithium metal battery has been regarded as promising next-generation battery system aiming for higher energy density. However, the lithium metal anode suffers severe side-reaction and dendrite issues. Its electrochemical performance is significantly depended on the electrolyte components and solvation structure. Herein, a series of fluorinated ethers are synthesized with weak-solvation ability owing to the duple steric effect derived from the designed longer carbon chain and methine group. The electrolyte solvation structure rich in AGGs (97...
March 27, 2024: Angewandte Chemie
https://read.qxmd.com/read/38535858/comparison-of-detomidine-or-romifidine-in-combination-with-morphine-for-standing-magnetic-resonance-imaging-in-horses
#8
JOURNAL ARTICLE
Cecilia Vullo, Enrico Gugliandolo, Vito Biondi, Marco Biffarella, Giuseppe Catone, Adolfo Maria Tambella
The aim of this study was to determine the most appropriate sedation protocol for a standing magnetic resonance imaging (MRI) examination in horses, comparing continuous rate infusions (CRIs) of detomidine and romifidine combined with a single bolus of morphine. Sixteen horses referred for standing low-field open-magnet MRI were randomly assigned to one of two sedation protocols. The horses were premedicated with 0.03 mg/kg of intramuscular acepromazine, and those animals belonging to Group D received an intravenous (IV) loading dose of detomidine (0...
March 8, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535810/environmental-toxin-biliatresone-induced-biliary-atresia-like-abnormal-cilia-and-bile-duct-cell-development-of-human-liver-organoids
#9
JOURNAL ARTICLE
Yue Hai-Bing, Menon Sudheer Sivasankaran, Babu Rosana Ottakandathil, Wu Zhong-Luan, So Man-Ting, Chung Patrick Ho-Yu, Wong Kenneth Kak-Yuen, Tam Paul Kwong-Hang, Lui Vincent Chi-Hang
Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns. Biliatresone, a plant toxin, causes BA-like syndrome in some animals, but its relevance in humans is unknown. To validate the hypothesis that biliatresone exposure is a plausible BA disease mechanism in humans, we treated normal human liver organoids with biliatresone and addressed its adverse effects on organoid development, functions and cellular organization. The control organoids (without biliatresone) were well expanded and much bigger than biliatresone-treated organoids...
March 11, 2024: Toxins
https://read.qxmd.com/read/38535786/bee-venom-composition-and-anticancer-properties
#10
REVIEW
Goran Gajski, Elina Leonova, Nikolajs Sjakste
Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535776/chelating-additive-regulating-zn-ion-solvation-chemistry-for-highly-efficient-aqueous-zinc-metal-battery
#11
JOURNAL ARTICLE
Dongming Xu, Xueting Ren, Haoyu Li, Yuran Zhou, Simin Chai, Yining Chen, Hang Li, Lishun Bai, Zhi Chang, Anqiang Pan, Haoshen Zhou
Aqueous zinc-metal batteries (AZMBs) usually suffered from poor reversibility and limited lifespan because of serious water induced side-reactions, hydrogen evolution reactions (HER) and rampant zinc (Zn) dendrite growth. Reducing the content of water molecules within Zn-ion solvation sheaths can effectively suppress those inherent defects of AZMBs. In this work, we originally discovered that the two carbonyl groups of N-Acetyl-ε-caprolactam (N-ac) chelating ligand can serve as dual solvation sites to coordinate with Zn2+, thereby minimizing water molecules within Zn-ion solvation sheaths, and greatly inhibit water-induced side-reactions and HER...
March 27, 2024: Angewandte Chemie
https://read.qxmd.com/read/38535737/impact-force-and-velocities-for-kicking-strikes-in-combat-sports-a-literature-review
#12
REVIEW
Daniel Corcoran, Mike Climstein, John Whitting, Luke Del Vecchio
Kicking strikes are fundamental in combat sports such as Taekwondo, karate, kickboxing, Muay Thai, and mixed martial arts. This review aimed to explore the measurement methods, kinematics such as velocities, kinetics such as impact force, determinants, and injury potential of kicking strikes in combat sports. Searches of Academic Search Premier, The Allied and Complementary Medicine Database, CINAHL Plus, MEDLINE, SPORTDiscus, Scopus, and Web of Science databases were conducted for studies that measured kicking velocity and impact force...
March 6, 2024: Sports
https://read.qxmd.com/read/38535582/brucellar-endocarditis-of-the-tricuspid-valve-a-case-report-and-review-of-the-literature
#13
Evangelo Boumis, Pierangelo Chinello, Vincenzo Galati, Simone Topino, Francesca Gavaruzzi, Stefania Cicalini
Brucellar endocarditis is a rare entity commonly described as a severe disease associated with high mortality and generally requiring valve surgery for cure. Right-sided endocarditis, a very uncommon presentation of brucellosis, may be associated with a better prognosis. We describe the case of a 72-year-old woman admitted to our institution with a persistent fever and multiple pulmonary infiltrates. Transthoracic echocardiography and serologic tests led to the diagnosis of brucellar tricuspid endocarditis...
March 8, 2024: Pathogens
https://read.qxmd.com/read/38535286/numerical-simulation-of-mass-transfer-in-hollow-fiber-membrane-module-for-membrane-based-artificial-organs
#14
JOURNAL ARTICLE
Ziheng Wang, Shaofeng Xu, Yifan Yu, Wei Zhang, Xuechang Zhang
The mass transfer behavior in a hollow fiber membrane module of membrane-based artificial organs (such as artificial liver or artificial kidney) were studied by numerical simulation. A new computational fluid dynamics (CFD) method coupled with K-K equation and the tortuous capillary pore diffusion model (TCPDM) was proposed for the simulations. The urea clearance rate predicted by the use of the numerical model agrees well with the experimental data, which verifies the validity of our numerical model. The distributions of concentration, pressure, and velocity in the hollow fiber membrane module were obtained to analyze the mass transfer behaviors of bilirubin and bovine serum albumin (BSA), and the effects of tube-side flow rate, shell-side flow rate, and fiber tube length on the bilirubin or BSA clearance rate were studied...
March 10, 2024: Membranes
https://read.qxmd.com/read/38535285/permeance-of-condensable-gases-in-rubbery-polymer-membranes-at-high-pressure
#15
JOURNAL ARTICLE
Karina Schuldt, Jelena Lillepärg, Jan Pohlmann, Torsten Brinkmann, Sergey Shishatskiy
The gas transport properties of thin film composite membranes (TFCMs) with selective layers of PolyActive™, polydimethylsiloxane (PDMS), and polyoctylmethylsiloxane (POMS) were investigated over a range of temperatures (10-34 °C; temperature increments of 2 °C) and pressures (1-65 bar abs; 38 pressure increments). The variation in the feed pressure of condensable gases CO2 and C2 H6 enabled the observation of peaks of permeance in dependence on the feed pressure and temperature. For PDMS and POMS, the permeance peak was reproduced at the same feed gas activity as when the feed temperature was changed...
March 6, 2024: Membranes
https://read.qxmd.com/read/38535268/toxicological-evaluation-toward-refined-montmorillonite-with-human-colon-associated-cells-and-human-skin-associated-cells
#16
JOURNAL ARTICLE
Zhou Wang, Yibei Jiang, Guangjian Tian, Chuyu Zhu, Yi Zhang
Montmorillonite has been refined to overcome uncertainties originating from different sources, which offers opportunities for addressing various health issues, e.g., cosmetics, wound dressings, and antidiarrheal medicines. Herein, three commercial montmorillonite samples were obtained from different sources and labeled M1, M2, and M3 for Ca-montmorillonite, magnesium-enriched Ca-montmorillonite, and silicon-enriched Na-montmorillonite, respectively. Commercial montmorillonite was refined via ultrasonic scission-differential centrifugation and labeled S, M, or L according to the particle sizes (small, medium, or large, respectively)...
March 20, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535260/effect-of-dmso-on-structural-properties-of-dmpc-and-dppc-liposome-suspensions
#17
JOURNAL ARTICLE
Luísa M P F Amaral, Maria Rangel, Margarida Bastos
The study and characterization of the biophysical properties of membranes and drug-membrane interactions represent a critical step in drug development, as biological membranes act as a barrier that the drug must overcome to reach its active site. Liposomes are widely used in drug delivery to circumvent the poor aqueous solubility of most drugs, improving systemic bioavailability and pharmacokinetics. Further, they can be targeted to deliver to specific disease sites, thus decreasing drug load, and reducing side effects and poor adherence to treatment...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535236/a-comprehensive-assessment-of-ultraviolet-radiation-induced-mutations-in-flammulina-filiformis-using-whole-genome-resequencing
#18
JOURNAL ARTICLE
Qianhui Huang, Xing Han, Zongjun Tong, Youjin Deng, Luyu Xie, Shengrong Liu, Baogui Xie, Weirui Zhang
Nucleotide substitutions have played an important role in molecular evolution, and understanding their dynamics would contribute to genetic studies. Related research with defined DNA sequences lasted for decades until whole-genome sequencing arose. UV radiation (UVR) can generate base changes and other genetic variations in a short period of time, so it would be more meaningful to explore mutations caused by UVR from a genomic perspective. The monokaryon enoki strain WT583 was selected as the experimental material in this study because it can spontaneously produce large amounts of oidia on PDA plates, and the monokaryons originating from oidia have the same genotype as their mother monokaryon...
March 20, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535074/combined-anti-pd-1-and-anti-ctla-4-treatment-in-stage-iv-melanoma-patients-a-bicentric-analysis-of-real-world-data-and-a-modern-treatment-scenario-proving-lactate-dehydrogenase-s-usefulness
#19
JOURNAL ARTICLE
Alexandru Dorin Adrian Silași, Anna Carolin Sievert, Paul Danciu, Andrei Vlad Lefter, Vlad Adrian Afrasanie, Daniel Sur
BACKGROUND: This retrospective study evaluates patients with stage IV melanoma treated with nivolumab and ipilimumab combination therapy from two regional oncology centers in Romania from the year 2019 to the end of 2022. METHODS: The data were analyzed in SAS for Windows, V9.4. LDH means were stratified by the number of metastatic sites before treatment and compared using an independent sample T-test. The survival curves were estimated using the Kaplan-Meier method, and the survival distributions were compared with the log-rank test...
March 20, 2024: Diagnostics
https://read.qxmd.com/read/38535010/relationship-between-bilateral-landmarks-of-facial-asymmetry-in-skeletal-class-ii-and-class-iii-in-vertical-dimension-3d-facial-scan-and-cone-beam-computed-tomography
#20
JOURNAL ARTICLE
Tanapat Jearanai, Bancha Samruajbenjakun, Pannapat Chanmanee
Significant facial asymmetry can lead to both functional and aesthetic issues. Often, such asymmetry originates from irregularities in the jaw structure. It is critical to recognize that asymmetries can be concealed by soft tissue, which may be overlooked. The aim of this study is to investigate the relationships between bilateral landmarks in the vertical dimension of facial asymmetry among individuals with skeletal Class II and Class III malocclusions. Fifty-two adult patients with a mean age of 24.4 ± 3...
March 11, 2024: Diagnostics
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