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https://www.readbyqxmd.com/read/28453557/perivascular-radiofrequency-renal-denervation-lowers-blood-pressure-and-ameliorates-cardiorenal-fibrosis-in-spontaneously-hypertensive-rats
#1
Shujie Wei, Dan Li, Yan Zhang, Linan Su, Yunrong Zhang, Qiang Wang, Dachun Yang, De Li, Yongjian Yang, Shuangtao Ma
BACKGROUND: Catheter-based renal denervation (RDN) is a promising approach to treat hypertension, but innervation patterns limit the response to endovascular RDN and the post-procedural renal artery narrowing or stenosis questions the endovascular ablation strategy. This study was performed to investigate the anti-hypertensive and target organ protective effects of perivascular RDN in spontaneously hypertensive rats (SHR). METHODS: SHR and normotensive Wistar-Kyoto (WKY) rats were divided into sham group (n = 10), radiofrequency ablation group (n = 20) in which rats received bilateral perivascular ablation with radiofrequency energy (2 watts), and chemical (10% phenol in 95% ethanol) ablation group (n = 12)...
2017: PloS One
https://www.readbyqxmd.com/read/28448180/renal-denervation-decreases-blood-pressure-and-renal-tyrosine-hydroxylase-but-does-not-augment-the-effect-of-hypotensive-drugs
#2
Janusz Skrzypecki, Maciej Gawlak, Tomasz Huc, Paweł Szulczyk, Marcin Ufnal
The effect of renal denervation on the efficacy of antihypertensive drugs has not yet been elucidated. Twenty-week-old spontaneously hypertensive rats were treated with metoprolol, losartan, indapamide, or saline (controls) and assigned to renal denervation or a sham procedure. Acute hemodynamic measurements were performed ten days later. Series showing a significant interaction between renal denervation and the drugs were repeated with chronic telemetry measurements. In the saline series, denervated rats showed a significantly lower mean arterial blood pressure (blood pressure) than the sham-operated rats...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28446003/effects-of-canine-and-murine-mesenchymal-stromal-cell-transplantation-on-peripheral-nerve-regeneration
#3
Diego Noe Rodriguez Sanchez, Matheus Bertanha, Thiago Dias Fernandes, Luiz Antônio de Lima Resende, Elenice Deffune, Rogério Martins Amorim
Background and Objectives: Maintaining a permissive microenvironment is essential for adequate nerve regeneration. Cell-based therapy has the potential based cell replacement and promotion of axonal growth. The adipose tissue derived mesenchymal stromal cells (Ad-MSC) attract interest because neuroregenerative and anti-inflammatory properties. The aim of this study was to evaluate the effects of canine and murine Ad-MSC transplantation on the sciatic nerve regeneration. Methods: Forty Wistar rats were divided randomly into: control group - CG (n=8); denervated group - DG (n=8); decellularized vein group - VG (n=8); decellularized vein+canine MSC-cMSC (n=8); descellularized vein+murine MSC-mMSC (n=8)...
April 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28445258/renal-vascular-calcification-and-response-to-renal-nerve-denervation-in-resistant-hypertension
#4
Annemiek F Hoogerwaard, Mark R de Jong, Ahmet Adiyaman, Jaap Jan J Smit, Peter P H M Delnoy, Jan-Evert Heeg, Boudewijn A A M van Hasselt, Anand R Ramdat Misier, Arif Elvan
Renal sympathetic nerve denervation (RDN) is accepted as a treatment option for patients with resistant hypertension. However, results on decline in ambulatory blood pressure (BP) measurement (ABPM) are conflicting. The high rate of nonresponders may be related to increased systemic vascular stiffness rather than sympathetic overdrive. A single center, prospective registry including 26 patients with treatment resistant hypertension who underwent RDN at the Isala Hospital in the Netherlands. Renal perivascular calcium scores were obtained from noncontrast computed tomography scans...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445207/effect-of-renal-sympathetic-denervation-on-short-term-blood-pressure-variability-in-resistant-hypertension-a-meta-analysis
#5
Nikos Vogiatzakis, Costas Tsioufis, Georgios Georgiopoulos, Costas Thomopoulos, Kyriakos Dimitriadis, Alexandros Kasiakogias, Dimitrios Konstantinidis, Thodoris Kalos, Felix Mahfoud, Michael Doumas, Vasilios Papademetriou, Dimitrios Tousoulis
BACKGROUND/OBJECTIVES: Short-term blood pressure variability (BPV) is affected by multiple factors including the sympathetic nervous system drive. Regarding the latter, the novel interventional technology of renal denervation (RDN), by modulating the sympathetic system activation, could have a beneficial impact on BPV. The aim of the current study is to review and meta-analyze the available evidence on the effect of RDN on short-term BPV. METHODS: We searched Medline/PubMed database until October 2016 for studies with eligible content...
April 25, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28444093/electrical-stimulation-attenuates-morphological-alterations-and-prevents-atrophy-of-the-denervated-cranial-tibial-muscle
#6
Cleuber Rodrigo de Souza Bueno, Mizael Pereira, Idvaldo Aparecido Favaretto, Carlos Henrique Fachin Bortoluci, Thais Caroline Pereira Dos Santos, Daniel Ventura Dias, Letícia Rossi Daré, Geraldo Marco Rosa
Objective: To investigate if electrical stimulation through Russian current is able to maintain morphology of the cranial tibial muscle of experimentally denervated rats. Methods: Thirty-six Wistar rats were divided into four groups: the Initial Control Group, Final Control Group, Experimental Denervated and Treated Group, Experimental Denervated Group. The electrostimulation was performed with a protocol of Russian current applied three times per week, for 45 days...
January 2017: Einstein
https://www.readbyqxmd.com/read/28443356/sham-or-no-sham-control-that-is-the-question-in-trials-of-renal-denervation-for-resistant-hypertension-a-systematic-meta-analysis
#7
Fadl Elmula M Fadl Elmula, Ying-Mei Feng, Lotte Jacobs, Anne C Larstorp, Sverre E Kjeldsen, Alexandre Persu, Jan A Staessen
BACKGROUND: Studies of renal denervation (RDN) in patients with apparent treatment resistant hypertension have been hampered by a number of patient and physician related confounders on blood pressure (BP) including poor drug adherence. It remains uncertain whether RDN lowers BP. We aimed to investigate whether the use of sham control is essential in RDN studies or whether systematic use of 24-hour ambulatory BP provides enough information thereby making an invasive sham control redundant...
April 26, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28442746/ultrastructural-characterization-of-the-lower-motor-system-in-a-mouse-model-of-krabbe-disease
#8
Valentina Cappello, Laura Marchetti, Paola Parlanti, Silvia Landi, Ilaria Tonazzini, Marco Cecchini, Vincenzo Piazza, Mauro Gemmi
Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells. Despite the wide use of Twitcher mice as experimental model for KD, the ultrastructure of this model is partial and mainly addressing peripheral nerves. More details are requested to elucidate the basis of the motor defects, which are the first to appear during KD onset. Here we use transmission electron microscopy (TEM) to focus on the alterations produced by KD in the lower motor system at postnatal day 15 (P15), a nearly asymptomatic stage, and in the juvenile P30 mouse...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28442357/dl-3-n-butylphthalide-promotes-neuroplasticity-and-motor-recovery-in-stroke-rats
#9
Yefei Sun, Xi Cheng, Huibin Wang, Xiaopeng Mu, Yifan Liang, YuJia Luo, Huiling Qu, Chuansheng Zhao
BACKGROUNDS AND AIMS: Racemic l-3-n-butylphthalide (dl-NBP), is able to achieve a functional recovery in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease. In this study, we investigated the effect of dl-NBP on axonal growth, neurogenesis and behavioral performances in rats with cerebral ischemia. METHODS: Focal cerebral ischemia in rats was produced by intracerebral injection of endothelin-1. Starting from postoperative day 7, the experimental rats were administered 70mg/kg dl-NBP by oral gavage for two weeks...
April 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28441700/ultrasound-based-renal-sympathetic-denervation-for-the-treatment-of-therapy-resistant-hypertension-a-single-center-experience
#10
Karl Fengler, Robert Höllriegel, Thomas Okon, Thomas Stiermaier, Karl-Philipp Rommel, Stephan Blazek, Christian Besler, Max von Roeder, Martin Petzold, Gerhard Schuler, Philipp Lurz
INTRODUCTION: The effectiveness of renal sympathetic denervation (RDN) as a treatment for therapy-resistant hypertension has been doubted as the Simplicity-HTN-3 trial was unable to show any treatment benefit over sham procedure. This might partly be explained by a high procedural variability in treatment with radiofrequency-based catheters. Recently, newer systems for RDN, like ultrasound-based devices, have been introduced into practice. To date however, data on their effectiveness for the treatment of resistant hypertension are scarce...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28436415/blood-pressure-reduction-in-patients-with-accessory-renal-arteries-and-bilateral-single-renal-arteries-after-catheter-based-renal-denervation-prospective-study-with-3-year-follow-up
#11
Krzysztof Bartus, Jakub Podolec, Jerzy Sadowski, Radosław Litwinowicz, Wojciech Zajdel, Magdalena Bartus, Janusz Konstanty-Kalandyk, Artur Dziewierz, Rafał Trąbka, Stanisław Bartus, Anna Chrapusta, Bogusław Kapelak
INTRODUCTION    Catheter-based renal denervation is an effective treatment leading to significant reduction of systolic and diastolic blood pressure in patients with resistant hypertension. OBJECTIVES    The aim of this prospective study was to assess the BP-lowering effect and pulse pressure lowering effects in patients with accessory and bilateral single renal arteries after catheter-based renal denervation procedure in a 3-year follow-up period. PATIENTS AND METHODS    31 patients with diagnosed resistant hypertension were enrolled in this study...
April 24, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28433644/supraspinal-respiratory-plasticity-following-acute-cervical-spinal-cord-injury
#12
Tatiana Bezdudnaya, Vitaliy Marchenko, Lyandysha V Zholudeva, Victoria M Spruance, Michael A Lane
Impaired breathing is a devastating result of high cervical spinal cord injuries (SCI) due to partial or full denervation of phrenic motoneurons, which innervate the diaphragm - a primary muscle of respiration. Consequently, people with cervical level injuries often become dependent on assisted ventilation and are susceptible to secondary complications. However, there is mounting evidence for limited spontaneous recovery of respiratory function following injury, demonstrating the neuroplastic potential of respiratory networks...
April 19, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28432873/conditional-deletion-of-bmal1-accentuates-microvascular-and-macrovascular-injury
#13
Ashay D Bhatwadekar, Eleni Beli, Diao Yanpeng, Jonathan Chen, Qianyi Luo, Alpha Alex, Sergio Caballero, James M Dominguez, Tatiana E Salazar, Julia V Busik, Mark S Segal, Maria B Grant
The brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein (BMAL)-1 constitutes a major transcriptional regulator of the circadian clock. Here, we explored the impact of conditional deletion of Bmal1 in endothelium and hematopoietic cells in murine models of microvascular and macrovascular injury. We used two models of Bmal1(fx/fx);Tek-Cre mice, a retinal ischemia/reperfusion model and a neointimal hyperplasia model of the femoral artery. Eyes were enumerated for acellular capillaries and were stained for oxidative damage markers using nitrotyrosine immunohistochemistry...
April 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28431026/minimally-invasive-sacroiliac-joint-fusion-radiofrequency-denervation-and-conservative-management-for-sacroiliac-joint-pain-6-year-comparative-case-series
#14
Vicente Vanaclocha, Juan Manuel Herrera, Nieves Sáiz-Sapena, Marlon Rivera-Paz, Francisco Verdú-López
BACKGROUND: Sacroiliac joint (SIJ) pain is an under-recognized condition. Substantial information supports the safety and effectiveness of SIJ fusion (SIJF). Long-term follow-up after SIJF has not been reported. OBJECTIVE: To determine responses to conservative management (CM), SIJ denervation, and SIJF in patients with SIJ pain unresponsive to CM. METHODS: Retrospective study with long-term (up to 6 yr) follow-up of 137 patients with SIJ pain seen in an outpatient neurosurgery clinic who received either CM (n = 63), sacroiliac denervation (n = 47), or minimally invasive SIJF (n = 27)...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28430843/carotid-body-denervation-markedly-improves-survival-in-rats-with-hypertensive-heart-failure
#15
Kana Fujii, Keita Saku, Takuya Kishi, Yasuhiro Oga, Takeshi Tohyama, Takuya Nishikawa, Takafumi Sakamoto, Masataka Ikeda, Tomomi Ide, Hiroyuki Tsutsui, Kenji Sunagawa
BACKGROUND: Hypertension is a major cause of heart failure. Excessive sympathoexcitation in patients with heart failure leads to poor prognosis. Since carotid body denervation (CBD) has been shown to reduce sympathetic nerve activity in animal models of hypertension and heart failure, we examined if bilateral CBD attenuates the progression of hypertensive heart failure and improves survival. METHODS: We randomly allocated Dahl salt-sensitive rats fed a high-salt diet from 6 weeks of age into CBD (n = 31) and sham-operation (SHAM; n = 50) groups, and conducted CBD or SHAM at 7 weeks of age...
April 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28428900/asymptomatic-severe-vagal-and-sympathetic-cardiac-denervation-in-holmes-adie-s-syndrome
#16
B Estañol, R C Callejas-Rojas, S Cortés, R Martínez-Memije, O Infante-Vázquez, G Delgado-García
A 40-year-old woman was found to have bilateral Adie's pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic blood pressure variability (SBPV) in supine and standing position and also during rhythmic breathing. We found a decreased HRV in the time domain with very low standard deviation in supine and standing position and during rhythmic breathing...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28426701/exploratory-study-on-the-effect-of-osteoactivin-on-muscle-regeneration-in-a-rat-volumetric-muscle-loss-model
#17
Jinjin Ma, Andrew R Baker, Anthony Calabro, Kathleen A Derwin
Wounds causing extensive injury loss of muscle, also known as volumetric muscle loss (VML), are frequently associated with high-energy civilian trauma and combat-related extremity injuries. Currently, no effective clinical therapy is available for promoting de novo muscle tissue regeneration to restore muscle function following VML. Recent studies have shown evidence that osteoactivin (OA), a transmembrane glycoprotein, has the ability to prevent skeletal muscle atrophy in response to denervation. Therefore the objective of this study is to investigate the potential regenerative effect of OA embedded and delivered via a cross-linked gelatin hydrogel within a volumetric tibialis anterior muscle defect in a rat model...
2017: PloS One
https://www.readbyqxmd.com/read/28423234/pulmonary-vein-isolation-with%C3%A2-concomitant%C3%A2-renal-artery-denervation%C3%A2-is-associated-with-reduction-of-both-arterial-blood-pressure-and-atrial-fibrillation-burden-data-from-implantable-cardiac-monitor
#18
Alexander Romanov, Evgeny Pokushalov, Dmitry Ponomarev, Artem Strelnikov, Vitaliy Shabanov, Denis Losik, Alexander Karaskov, Jonathan S Steinberg
BACKGROUND: Renal artery denervation (RDN) has provided incremental atrial fibrillation (AF) suppression after pulmonary vein isolation (PVI) in patients with AF in the setting of drug-resistant hypertension. OBJECTIVE: To assess the relationship between changes of mean blood pressure (BP) and AF recurrences/AF burden after PVI combined with RDN. METHODS: All patients from two randomized studies with symptomatic paroxysmal AF and/or persistent AF and resistant hypertension who underwent PVI only (n=37) or PVI with RDN (n=39), and implantable cardiac monitor (ICM) implantation, were eligible for this study...
April 19, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28421719/therapeutic-value-of-renal-denervation-in-cardiovascular-disease
#19
EDITORIAL
M Carlstrom
No abstract text is available yet for this article.
May 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28419739/cardiac-troponin-t-and-fast-skeletal-muscle-denervation-in-ageing
#20
Zherong Xu, Xin Feng, Juan Dong, Zhong-Min Wang, Jingyun Lee, Cristina Furdui, Daniel Clark Files, Kristen M Beavers, Stephen Kritchevsky, Carolanne Milligan, Jian-Ping Jin, Osvaldo Delbono, Tan Zhang
BACKGROUND: Ageing skeletal muscle undergoes chronic denervation, and the neuromuscular junction (NMJ), the key structure that connects motor neuron nerves with muscle cells, shows increased defects with ageing. Previous studies in various species have shown that with ageing, type II fast-twitch skeletal muscle fibres show more atrophy and NMJ deterioration than type I slow-twitch fibres. However, how this process is regulated is largely unknown. A better understanding of the mechanisms regulating skeletal muscle fibre-type specific denervation at the NMJ could be critical to identifying novel treatments for sarcopenia...
April 16, 2017: Journal of Cachexia, Sarcopenia and Muscle
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