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https://www.readbyqxmd.com/read/28634514/cystic-lesions-of-peripheral-nerves-are-we-missing-the-diagnosis-of-the-intraneural-ganglion-cyst
#1
Jyoti Panwar, Anil Mathew, Binu P Thomas
AIM: To highlight the salient magnetic resonance imaging (MRI) features of the intraneural ganglion cyst (INGC) of various peripheral nerves for their precise diagnosis and to differentiate them from other intra and extra-neural cystic lesions. METHODS: A retrospective analysis of the magnetic resonance (MR) images of a cohort of 245 patients presenting with nerve palsy involving different peripheral nerves was done. MR images were analyzed for the presence of a nerve lesion, and if found, it was further characterized as solid or cystic...
May 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28632904/ngf-and-fgf-2-promote-reinnervation-by-nerve-muscle-endplate-grafting
#2
Liancai Mu, Stanislaw Sobotka, Jingming Chen, Themba Nyirenda
INTRODUCTION: This study was designed to test whether exogenous application of nerve growth factor (NGF) and basic fibroblast growth factor (FGF-2) to muscles reinnervated with nerve-muscle-endplate band grafting (NMEG) could promote specific outcomes. METHODS: The right sternomastoid muscle in adult rats was experimentally denervated and immediately reinnervated by implanting a NMEG pedicle from the ipsilateral sternohyoid muscle. A fibrin sealant containing NGF and FGF-2 was focally applied to the implantation site...
June 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632750/renal-sodium-handling-and-blood-pressure-changes-in-gestational-protein-restricted-offspring-role-of-renal-nerves-and-ganglia-neurokinin-expression
#3
Augusto H Custódio, Marcelo C de Lima, Bárbara Vaccari, Patrícia A Boer, José A R Gontijo
BACKGROUND: Considering long-term changes in renal sodium handling and blood pressure in maternal protein-restricted (LP) offspring, we assumed that the development of LP hypertension results from abnormal dorsal root ganglia (DRG) neurokinin expression associated with impaired responsiveness of renal sensory receptors, promoting a reduced urinary excretion of sodium. The present study investigates whether increased blood pressure in protein-restricted offspring would be associated with changes in the DRG cells and in renal pelvic wall expression of NK1R, SP and CGRP when compared to NP offspring...
2017: PloS One
https://www.readbyqxmd.com/read/28632695/serum-ceruloplasmin-and-striatal-dopamine-transporter-density-in-parkinson-disease-comparison-with-123i-fp-cit-spect
#4
Yoo Sung Song, Jong-Min Kim, Kyeong Joon Kim, Ji Young Yun, Sang Eun Kim
PURPOSE: In patients with Parkinson disease (PD), decreased serum ceruloplasmin levels have been observed. This study investigated a correlation between serum ceruloplasmin-along with its related serum markers- and striatal presynaptic dopaminergic denervation measured with I-FP-CIT SPECT. METHODS: We analyzed a total of 141 de novo patients divided into 2 groups: the PD group (107 patients with PD) and the disease control group (34 patients with vascular pseudoparkinsonism, essential tremor, or drug-induced parkinsonism)...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28627693/renal-denervation-attenuates-cardiac-hypertrophy-in-spontaneously-hypertensive-rats-via-regulation-of-autophagy
#5
Jionghua Huang, He Huang, Wei Pan, Dejin Ou, Wenjun Dai, Yuhui Lin, Jinlei Wu, Wenjie Xie, Ximing Chen
It has been suggested that renal denervation (RD) may attenuate left ventricular (LV) hypertrophy. However, the role that autophagy serves in this process is currently unclear. In the present study, utilizing a model of hypertension‑induced cardiac hypertrophy in spontaneous hypertensive rats, it was demonstrated that RD was significantly associated with a reduction in LV hypertrophy. Furthermore, a decrease in the myocardial mRNA of hypertrophy‑associated genes was demonstrated in RD rats compared with sham controls...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28621056/denervation-effectively-aggravates-rat-experimental-periodontitis
#6
X Yu, Z Gong, Q Lin, W Wang, S Liu, S Li
BACKGROUND: Nerve and its related factors in the occurrence and development of periodontitis are worthy of further study. Denervation research is a useful addition to nerve and innervation studies. The aim of this study is to establish a rat model of inferior alveolar nerve transection combined with ligature-induced periodontitis to elucidate the effects of denervation on ligature-induced rat periodontitis. MATERIAL AND METHODS: Sixty-four Wistar rats were distributed to the four groups randomly: ligation (L); denervation (D); ligation+denervation (LD); and normal (N) as control...
June 16, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28620841/device-based-approaches-for-the-treatment-of-arterial-hypertension
#7
REVIEW
Jens Jordan
Device-based antihypertensive treatments have primarily been developed and clinically tested for patients with hypertension refractory to pharmacological treatment. Most but not all device-based treatments target the sympathetic nervous system and provided important new insight in the mechanisms of human hypertension. This review provides an overview on the scientific rational and clinical data on recent device-based antihypertensive treatment approaches. Device-based treatments targeting the sympathetic nervous system include catheter-based renal nerve ablation, electrical carotid sinus stimulation, modulation of baroreflex transduction through a dedicated carotid stent, carotid body denervation, and deep brain stimulation...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28616718/effect-of-intrastriatal-6-ohda-lesions-on-extrastriatal-brain-structures-in-the-mouse
#8
Birte Becker, Melek Demirbas, Sonja Johann, Adib Zendedel, Cordian Beyer, Hans Clusmann, Stefan Jean-Pierre Haas, Andreas Wree, Sonny Kian Hwie Tan, Markus Kipp
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor and non-motor symptoms. The underlying pathology of non-motor symptoms is poorly understood. Discussed are pathological changes of extrastriatal brain structures. In this study, we characterized histopathological alterations of extrastriatal brain structures in the 6-hydroxydopamine (6-OHDA) PD animal model. Lesions were induced by unilateral stereotactic injections of 6-OHDA into the striatum or medial forebrain bundle of adult male mice...
June 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28616552/effectiveness-of-renal-sympathetic-denervation-in-renal-function-and-blood-pressure-in-ckd-and-non-ckd-patients-with-controlled-vs-uncontrolled-hypertension
#9
Márcio Galindo Kiuchi, Shaojie Chen
No abstract text is available yet for this article.
December 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28616236/effect-of-applied-energy-in-renal-sympathetic-denervation-with-magnetic-resonance-guided-focused-ultrasound-in-a-porcine-model
#10
Jill Shea, Joshua de Bever, Eugene Kholmovski, Hannah Beal, J Rock Hadley, Emilee Minalga, Mohamed E Salama, Nassir F Marrouche, Allison Payne
BACKGROUND: Past catheter-based and focused ultrasound renal denervation studies have indicated that procedure efficacy is related to the number of ablations performed or the amount of energy used for the ablation. This study extends those prior results and investigates energy level effects on the efficacy of MR guided focused ultrasound renal denervation performed in a porcine model. METHODS: Twenty-four normotensive pigs underwent unilateral denervation at three intensity levels...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28616024/chronically-denervated-distal-nerve-stump-inhibits-peripheral-nerve-regeneration
#11
Giulia Ronchi, Stefania Raimondo
No abstract text is available yet for this article.
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615421/outcomes-of-colorado-children-with-acute-flaccid-myelitis-at-1-year
#12
Jan A Martin, Kevin Messacar, Michele L Yang, John A Maloney, Jennifer Lindwall, Terri Carry, Patricia Kenyon, Stefan H Sillau, Joyce Oleszek, Kenneth L Tyler, Samuel R Dominguez, Teri L Schreiner
OBJECTIVE: We describe long-term functional, neurodiagnostic, and psychosocial outcomes of a cohort of 12 children from Colorado diagnosed with acute flaccid myelitis (AFM) in 2014. METHODS: Children were assessed every 3 months for 1 year or until clinical resolution. Assessments included neurologic examination, MRI, EMG/nerve conduction studies (NCS), functional measures (Assisting Hand Assessment, Hammersmith Functional Motor Scale), and Patient-Reported Outcomes Measurement Information System questionnaires...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28614767/changes-in-caveolin-1-caveolin-3-and-vascular-endothelial-growth-factor-expression-and-protein-content-after-botulinum-toxin-a-injection-in-the-right-masseter-muscle-of-dystrophin-deficient-mdx-mice
#13
U U Botzenhart, V Vaal, I Rentzsch, T Gredes, T Gedrange, C Kunert-Keil
Progressive muscle wasting, frequently associated with inflammation, muscle fibre degeneration and fibrosis, is a characteristic of DMD (Duchenne muscular dystrophy). Its most common used animal model, the mdx mouse, however can overcome muscle degeneration by regeneration processes and is for this reason not suitable to answer all scientific questions. The aim of this study was to evaluate the ability of botulinum toxin A (BTX-A) in breaking down muscle regeneration in mdx mice. For this purpose, the right masseter muscle of 100 days old mdx and healthy mice was paralyzed by a single specific intramuscular injection of BTX-A...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28611687/the-effect-of-renal-denervation-on-plasma-adipokine-profile-in-patients-with-treatment-resistant-hypertension
#14
Nina Eikelis, Dagmara Hering, Petra Marusic, Jacqueline Duval, Louise J Hammond, Antony S Walton, Elisabeth A Lambert, Murray D Esler, Gavin W Lambert, Markus P Schlaich
Background: We previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. A number of adipocyte-derived factors are implicated in BP control in obesity. Aim: The aim of this study was to examine whether RDN may have salutary effects on the adipokine profile in patients with resistant hypertension (RH). Methods: Fifty seven patients with RH undergoing RDN program have been included in this study (65% males, age 60...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28608267/renal-denervation-as-a%C3%A2-treatment-strategy-for-vasospastic-angina-induced-ventricular-tachycardia
#15
L Feyz, S Wijchers, J Daemen
No abstract text is available yet for this article.
June 12, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28607624/percutaneous-renal-sympathetic-denervation-in-catecholaminergic-polymorphic-ventricular-tachycardia
#16
Tolga Aksu, Erdem Guler
Catheter-based renal sympathetic denervation may be an alternative after unsuccessful conventional ablation attempts.
June 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28607168/subthalamic-nucleus-deep-brain-stimulation-employs-trkb-signaling-for-neuroprotection-and-functional-restoration
#17
D Luke Fischer, Christopher J Kemp, Allyson Cole-Strauss, Nicole K Polinski, Katrina L Paumier, Jack W Lipton, Kathy Steece-Collier, Timothy J Collier, Daniel J Buhlinger, Caryl E Sortwell
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the most common neurosurgical treatment for Parkinson's disease motor symptoms. In preclinical models, STN DBS provides neuroprotection for substantia nigra (SN) dopamine neurons and increases brain-derived neurotrophic factor (BDNF) in the nigrostriatal system and primary motor cortex. However, whether BDNF signaling in the SN participates in the neuroprotective effects of DBS remains unknown. We demonstrate that STN DBS in male rats activates signaling downstream of tropomyosin receptor kinase type B (trkB), namely phosphorylation of Akt and ribosomal protein S6, in SN neurons...
June 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28600097/renal-denervation-to-modify-hypertension-and-the-heart-failure-state
#18
REVIEW
Ming Zhong, Luke K Kim, Rajesh V Swaminathan, Dmitriy N Feldman
Sympathetic overactivation of renal afferent and efferent nerves have been implicated in the development and maintenance of several cardiovascular disease states, including resistant hypertension and heart failure with both reduced and preserved systolic function. With the development of minimally invasive catheter-based techniques, percutaneous renal denervation has become a safe and effective method of attenuating sympathetic overactivation. Percutaneous renal denervation, therefore, has the potential to modify and treat hypertension and congestive heart failure...
July 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28598433/refinement-of-learned-skilled-movement-representation-in-motor-cortex-deep-output-layer
#19
Qian Li, Ho Ko, Zhong-Ming Qian, Leo Y C Yan, Danny C W Chan, Gordon Arbuthnott, Ya Ke, Wing-Ho Yung
The mechanisms underlying the emergence of learned motor skill representation in primary motor cortex (M1) are not well understood. Specifically, how motor representation in the deep output layer 5b (L5b) is shaped by motor learning remains virtually unknown. In rats undergoing motor skill training, we detect a subpopulation of task-recruited L5b neurons that not only become more movement-encoding, but their activities are also more structured and temporally aligned to motor execution with a timescale of refinement in tens-of-milliseconds...
June 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28592193/permanent-chronotropic-impairment-after-closure-of-atrial-or-ventricular-septal-defect
#20
Johan Heiberg, Camilla Nyboe, Vibeke E Hjortdal
OBJECTIVES: Atrial and ventricular septal defects are commonly closed surgically with low rates of post-operative morbidity, and the long-term outcome has widely been described as benign. Nevertheless, there is an increasing understanding of late morbidity, and the possibility of postoperative chronotropic impairment is continuously questioned. Furthermore, potentially abnormal chronotropic responses may be associated with the recently demonstrated overrepresentation of late arrhythmias...
June 8, 2017: Scandinavian Cardiovascular Journal: SCJ
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