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https://www.readbyqxmd.com/read/29054896/metastatic-melanoma-of-unknown-primary-in-the-temporalis-muscle
#1
Marco Dalle Carbonare, Mei Xien Goh, Zainab AlshiekhAli, David Howlett
Melanomas are aggressive cancers that present as cutaneous, mucosal and ocular lesions with the ability to metastasise widely. There are, however, occasions where lesions are found in distant sites such as lymph nodes, viscera and subcutaneous tissues without clinically apparent skin involvement. This is known as metastatic melanoma of unknown primary (MUP). Its presentation in skeletal muscle is rare, and the available literature is sparse. This article presents an 85-year-old woman with a MUP presenting in the right temporalis muscle, which was diagnosed with the aid of the ultrasound-guided core biopsy...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054718/determination-of-the-impact-of-melanoma-surgical-timing-on-survival-using-the-national-cancer-database
#2
Ruzica Z Conic, Claudia I Cabrera, Alok A Khorana, Brian R Gastman
BACKGROUND: The ideal timing for melanoma treatment, predominantly surgery, remains undetermined. Patient concern for receiving immediate treatment often exceeds surgeon or hospital availability, requiring establishment of a safe window for melanoma surgery. OBJECTIVE: To assess the impact of time to definitive melanoma surgery on overall survival. METHODS: Patients with stage I to III cutaneous melanoma and with available time to definitive surgery and overall survival were identified by using the National Cancer Database (N = 153,218)...
September 27, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29054599/indoleamine-2-3-dioxygenase-expression-in-primary-cutaneous-melanoma-correlates-with-breslow-thickness-and-is-of-significant-prognostic-value-for-progression-free-survival
#3
Felicia Rubel, Johannes S Kern, Kristin Technau-Hafsi, Sibylle Uhrich, Kaethe Thoma, Georg Häcker, Nikolas von Bubnoff, Frank Meiss, Dagmar von Bubnoff
The enzyme indoleamine 2,3-dioxygenase (IDO) is emerging as a facilitator of cancer development through its effects on cancer-associated inflammation. Recent studies report a significant improvement of the response rates in melanoma patients to PD-1 antibodies when IDO-inhibitors were added to the regimen. Data on IDO-expression in primary human melanomas are however incomplete and conflicting. Here, we show that the level of IDO-expression in primary human melanoma cells significantly correlates with Breslow thickness (p = 0...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29052960/treatment-and-outcomes-of-melanoma-in-asia-results-from-the-national-cancer-centre-singapore
#4
Yi Lin Teh, Wei Lin Goh, Sze Huey Tan, Grace Yong, Alisa Noor Hidayah Sairi, Khee Chee Soo, Johnny Ong, Claramae Chia, Grace Tan, Henry Soeharno, Mann Hong Tan, Michelle Chan, Selvarajan Sathiyamoorthy, Kesavan Sittampalam, Jonathan Teh, Francis Chin, Vijay Sethi, Melissa Teo, Richard Quek, Mohamad Farid
BACKGROUND: Acral melanoma (AM) and mucosal melanoma (MM) make up more than half of melanomas in Asia but comprise only 5% of cases in Caucasians, where cutaneous melanoma (CM) predominates. AM and MM are thought to be genetically and biologically distinct from CM. We report the characteristics and outcomes of melanoma patients from the National Cancer Centre Singapore. METHODS: Case records of 210 patients treated between 2002 and 2014 were reviewed. RESULTS: Median follow-up was 2...
October 20, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29052750/impact-of-a-cd4-gene-haplotype-on-the-immune-response-in-minipigs
#5
Fany Blanc, Françoise Créchet, Nicolas Bruneau, Guillaume Piton, Jean-Jacques Leplat, Fabrice Andréoletti, Giorgia Egidy, Silvia Vincent-Naulleau, Emmanuelle Bourneuf
The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive sequencing revealed a high genetic variability of CD4 and the existence of several haplotypes segregating in MeLiM. Forty polymorphisms were identified in the coding sequence, out of which 20 correspond to non-synonymous variants and 10 are located in the 3'UTR of CD4 transcripts...
October 20, 2017: Immunogenetics
https://www.readbyqxmd.com/read/29049843/metabolic-strategies-of-melanoma-cells-mechanisms-interactions-with-the-tumor-microenvironment-and-therapeutic-implications
#6
REVIEW
Grant M Fischer, Y N Vashisht Gopal, Jennifer L McQuade, Weiyi Peng, Ralph J DeBerardinis, Michael A Davies
Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a variety of fuels that facilitate tumor progression and metastasis. The significance of metabolism in melanoma is supported by growing evidence of impact on the efficacy of contemporary therapies for this disease. There is also data to support that the metabolic phenotypes of melanoma cells depend upon contributions from both intrinsic oncogenic pathways and extrinsic factors in the tumor microenvironment. This review summarizes current understanding of the metabolic processes that promote cutaneous melanoma tumorigenesis and progression, the regulation of cancer cell metabolism by the tumor microenvironment, and the impact of metabolic pathways on targeted and immune therapies...
October 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29049612/long-term-change-in-the-risk-of-skin-cancer-after-organ-transplantation-a-population-based-nationwide-cohort-study
#7
Syed Mohammad Husain Rizvi, Bjarte Aagnes, Hallvard Holdaas, Einar Gude, Kristin Muri Boberg, Øystein Bjørtuft, Per Helsing, Torbjørn Leivestad, Bjørn Møller, Petter Gjersvik
Importance: The high risk of skin cancer after organ transplantation is a major clinical challenge and well documented, but reports on temporal trends in the risk of posttransplant cutaneous squamous cell carcinoma (SCC) are few and appear contradictory. Objective: To study temporal trends for the risk of skin cancer, particularly SCC, after organ transplantation. Design, Setting, and Participants: Population-based, nationwide, prospective cohort study of 8026 patients receiving a kidney, heart, lung, or liver transplant in Norway from 1968 through 2012 using patient data linked to a national cancer registry...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29048595/ultraviolet-radiation-and-skin-cancer-risk-in-offshore-workers
#8
J S Stenehjem, T E Robsahm, M Bråtveit, S O Samuelsen, J Kirkeleit, T K Grimsrud
Background: Excess skin cancer mortality and incidence have been reported among both land-based and offshore petroleum workers. The association between skin cancer and ultraviolet radiation (UVR) exposure has not been examined in these workers, although they have long off-duty periods and high average income that may allow travelling to sunny destinations. In addition, they have access to solariums free of charge on many accommodation platforms. Aims: To prospectively examine risk of incident cutaneous melanoma (CM) and non-melanoma skin cancer (NMSC), according to sun-tanning habits with adjustment for aromatic hydrocarbon exposure...
October 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29044793/clustering-of-prevention-behaviours-in-patients-with-high-risk-primary-melanoma
#9
Adèle C Green, Maria Celia B Hughes, Lena A von Schuckmann, Kiarash Khosrotehrani, B Mark Smithers
OBJECTIVE: Because melanoma patients are at high risk of further disease, we aimed to study their melanoma prevention behaviours. METHODS: In a large cohort of patients newly diagnosed with high-risk melanoma in Queensland, Australia, we assessed clustering of preventive behaviours using latent class analysis. We assessed associated factors with prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) estimated by Poisson regression, and also if preventive behaviour was associated with better tumour prognosis at diagnosis...
October 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29044660/real-world-treatment-patterns-and-outcomes-among-metastatic-cutaneous-melanoma-patients-treated-with-ipilimumab
#10
P M Mohr, P A Ascierto, A A Arance, G M McArthur, A H Hernaez, P K Kaskel, R S Shinde, K S Stevinson
BACKGROUND: There is a scarcity of real-world data on treatment patterns and outcomes among advanced melanoma patients treated with immunotherapies including ipilimumab, an anti-CTLA-4 antibody approved since 2011. OBJECTIVE: To evaluate ipilimumab and post-ipilimumab treatment patterns and outcomes among patients with advanced melanoma in Australia, Germany, Italy and Spain following regulatory approval. METHODS: Retrospective multicentre, multinational, observational chart review study...
October 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29038913/-ocular-melanomas-an-update
#11
REVIEW
H Kalirai, P L Müller, D Jaehne, S E Coupland
Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression...
October 16, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29036293/rare-germline-variants-in-known-melanoma-susceptibility-genes-in-familial-melanoma
#12
Alisa M Goldstein, Yanzi Xiao, Joshua Sampson, Bin Zhu, Melissa Rotunno, Hunter Bennett, Yixuan Wen, Kristine Jones, Aurelie Vogt, Laurie Burdette, Wen Luo, Bin Zhu, Meredith Yeager, Belynda Hicks, Jiali Han, Immaculata De Vivo, Stella Koutros, Gabriella Andreotti, Laura Beane-Freeman, Mark Purdue, Neal D Freedman, Stephen J Chanock, Margaret A Tucker, Xiaohong R Yang
Known high-risk cutaneous malignant melanoma (CMM) genes account for melanoma risk in < 40% of melanoma-prone families, suggesting the existence of additional high-risk genes or perhaps a polygenic mechanism involving multiple genetic modifiers. The goal of this study was to systematically characterize rare germline variants in 42 established melanoma genes among 144 CMM patients in 76 American CMM families without known mutations using data from whole-exome sequencing. We identified 68 rare (<0.1% in public and in-house control datasets) nonsynonymous variants in 25 genes...
October 3, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036262/granuloma-annulare-secondary-to-vemurafenib-therapy-for-lung-adenocarcinoma
#13
Helena A Jenkinson, Alan E Siroy, Adrienne Choksi
Numerous cutaneous manifestations have been associated with use of BRAF inhibitors, including two previously reported cases of granuloma annulare (GA) eruptions associated with vemurafenib therapy. Both of these patients were being treated for metastatic melanoma. In this report, we describe the case of a 71-year-old man who developed classic GA lesions while being treated with vemurafenib monotherapy for nonmelanoma cancer, specifically metastatic lung adenocarcinoma positive for BRAF V600 mutation. <p><em>J Drugs Dermatol...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29036261/development-of-halo-nevi-in-a-lung-cancer-patient-a-novel-immune-related-cutaneous-event-from-atezolizumab
#14
Mathew R Birnbaum, Michelle W Ma, Michael A Casey, Bijal D Amin, Mark Jacobson, Haiying Cheng, Beth N McLellan
Immunotherapy-induced vitiligo is an immune-related adverse event (irAE) observed in metastatic melanoma patients treated with immune checkpoint inhibitors that target the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) pathways. To date, the development of leukoderma, poliosis, and halo nevi during immunotherapy has largely been reported in metastatic melanoma patients. We report a case of immunotherapy-induced leukoderma presenting as halo nevi in a patient with non-small cell lung cancer (NSCLC) treated with atezolizumab, a programmed cell death ligand (PD-L1) antibody...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29036257/improvement-of-actinic-keratoses-using-topical-dna-repair-enzymes-a-randomized-placebo-controlled-trial
#15
Marie Stoddard, Jennifer Herrmann, Lauren Moy, Ronald Moy
BACKGROUND: Actinic keratoses (AKs) are proliferations of abnormal keratinocytes, which may progress into non-melanoma skin cancers. Although multiple treatment modalities exist for AKs, their incidence continues to rise, making new methods of both prevention and treatment necessary. DNA repair enzymes have been shown to reverse sun-damage, resulting in reduced rates of AKs and non-melanoma skin cancer (NMSC) in specific patient populations. OBJECTIVE: We investigated the efficacy of a topical DNA repair enzyme lotion as a field therapy for AKs...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29034279/rare-and-extensive-malignant-melanoma-of-the-oral-cavity-report-of-two-cases
#16
Parviz Deyhimi, Sayed Mohammad Razavi, Shirin Shahnaseri, Saeedeh Khalesi, Solmaz Homayoni, Payam Tavakoli
Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor. This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29033813/recurrence-of-melanoma-after-starting-apremilast-for-psoriasis
#17
Thomas G Salopek
This is a report on a 32-year-old man with a history of two previous melanomas with concurrent plaque-type psoriasis. His history dates to 2009, when he was diagnosed with his first melanoma on the right occiput, Clark's level IV, tumor thickness 1.53 mm, nonulcerated, mitotic index 1/mm(2). He subsequently developed nodal recurrence after an initial negative sentinel lymph node biopsy and was treated with complete lymph node dissection. In 2012, he was diagnosed with a second primary melanoma on the right upper chest, Clark's level IV, tumor thickness 0...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033677/diagnostic-accuracy-and-impact-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-preoperative-staging-of-cutaneous-malignant-melanoma-results-of-a-prospective-study-in-indian-population
#18
Piyush Chandra, Nilendu Purandare, Sneha Shah, Archi Agrawal, Ajay Puri, Ashish Gulia, Venkatesh Rangarajan
The aim of the study was to evaluate the diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) in staging patients with primary cutaneous malignant melanoma (CMM). We further compared the performance of PET/CT with conventional imaging (CI) (CT and ultrasonography [USG]) and assessed the impact of PET/CT on disease management. This was a single institution, prospective, double-blinded study, recruiting a total of 70 treatment naïve patients. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of PET/CT for N staging were 86%, 96%, 80%, and 97%, respectively...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033353/melanocyte-stem-cell-activation-and-translocation-initiate-cutaneous-melanoma-in-response-to-uv-exposure
#19
Hyeongsun Moon, Leanne R Donahue, Eunju Choi, Philip O Scumpia, William E Lowry, Jennifer K Grenier, Jerry Zhu, Andrew C White
Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor initiation remain unclear. The majority of melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melanomas can arise from melanocyte stem cells (MCSCs). Here we employ mouse models to define the role of MCSCs as melanoma cells of origin, demonstrate that MCSC quiescence acts as a tumor suppressor, and identify the extrinsic environmental and molecular factors required for the critical early steps of melanoma initiation...
October 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29033351/mouse-cutaneous-melanoma-induced-by-mutant-braf-arises-from-expansion-and-dedifferentiation-of-mature-pigmented-melanocytes
#20
Corinna Köhler, David Nittner, Florian Rambow, Enrico Radaelli, Fabio Stanchi, Niels Vandamme, Arianna Baggiolini, Lukas Sommer, Geert Berx, Joost J van den Oord, Holger Gerhardt, Cedric Blanpain, Jean-Christophe Marine
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and transcriptomics approaches with time-lapse imaging. A mouse model that recapitulates key histopathological features of human melanomagenesis was created by inducing a BRafV600E-driven melanomagenic program in tail interfollicular melanocytes. Most targeted mature, melanin-producing melanocytes expanded clonally within the epidermis before losing their differentiated features through transcriptional reprogramming and eventually invading the dermis...
October 4, 2017: Cell Stem Cell
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