keyword
MENU ▼
Read by QxMD icon Read
search

Selection donor

keyword
https://www.readbyqxmd.com/read/29782618/liver-targeted-therapies-for-hepatocellular-carcinoma-prior-to-transplant-contemporary-management-strategies
#1
Mustafa Nazzal, Sameer Gadani, Abdullah Said, Mandy Rice, Obi Okoye, Ahmad Taha, Krista L Lentine
Hepatocellular carcinoma (HCC) is an aggressive neoplastic disease that has been rapidly increasing in incidence. It usually occurs in the background of liver disease, and cirrhosis. Definitive therapy requires surgical resection. However, in majority of cases surgical resection is not tolerated, especially in the presence of portal hypertension and cirrhosis. Orthotopic liver transplant (OLT) in well selected candidates has been accepted as a viable option. Due to a relative scarcity of donors compared to the number of listed recipients, long waiting times are anticipated...
April 2018: Glob Surg
https://www.readbyqxmd.com/read/29782203/extracellular-vesicles-extracted-from-young-donor-serum-attenuate-inflammaging-via-partially-rejuvenating-aged-t-cell-immunotolerance
#2
Weikan Wang, Liefeng Wang, Linhui Ruan, Jiyoung Oh, Xiaowei Dong, Qichuan Zhuge, Dong-Ming Su
Biologic aging results in a chronic inflammatory condition, termed inflammaging, which establishes a risk for such age-related diseases as neurocardiovascular diseases; therefore, it is of great importance to develop rejuvenation strategies that are able to attenuate inflammaging as a means of intervention for age-related diseases. A promising rejuvenation factor that is present in young blood has been found that can make aged neurons younger; however, the component in the young blood and its mechanism of action are poorly elucidated...
May 21, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29781853/the-use-of-pedicled-perforator-flaps-in-chest-reconstruction-a-systematic-review-of-outcomes-and-reliability
#3
Anne-Sophie Florczak, Benoit Chaput, Christian Herlin, Pascal Rousseau, Eric Watier, Nicolas Bertheuil
BACKGROUND: In recent years, pedicled perforator flaps have revolutionized plastic surgery by reducing donor site morbidity and ensuring larger and deeper reconstructions with local pedicled cutaneous flaps. The aim of the study was to make a systematic review of perforator pedicled propeller flaps (PPPFs) in chest reconstruction. METHODS: Pubmed and Cochrane databases were searched from 1989 to October 2016 for articles describing the use of PPPFs in chest reconstruction...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781684/husbands-participation-in-birth-preparedness-and-complication-readiness-and-associated-factors-in-wolaita-sodo-town-southern-ethiopia
#4
Minyahil Tadesse, Andualem T Boltena, Benedict O Asamoah
BACKGROUND:  The poor emphasis on the role of husbands in birth preparedness and complication readiness (BPCR) is a major factor that should be addressed in tackling maternal mortality. AIM:  To assess the level of husbands' participation in BPCR and associated factors. SETTING:  Wolaita Sodo town, Southern Ethiopia. METHODS:  A community based cross-sectional study was conducted among 608 husbands of pregnant women and nursing mothers...
April 11, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29780525/cyclometalated-gold-iii-complexes-noticeable-differences-between-n-c-and-p-c-ligands-in-migratory-insertion
#5
Jordi Serra, Pau Font, E Daiann Sosa Carrizo, Sonia Mallet-Ladeira, Stéphane Massou, Teodor Parella, Karinne Miqueu, Abderrahmane Amgoune, Xavi Ribas, Didier Bourissou
Gold(iii) complexes are garnering increasing interest for opto-electronic, therapeutic and catalytic applications. But so far, very little is known about the factors controlling their reactivity and the very influence of the ancillary ligand. This article reports the first comprehensive study on this topic. The reactivity of a cationic (N,C) gold(iii) complex, namely 1A , towards ethylene has been thoroughly studied and compared with that of the related (P,C) complex 1C . A cationic gold(iii) complex 5A resulting from double insertion of ethylene was selectively obtained...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779660/in-vitro-analysis-of-cyanobacterial-nonheme-iron-dependent-aliphatic-halogenases-welo5-and-ambo5
#6
Xinyu Liu
Aliphatic carbon-halogen (C-X) bonds are prevalent in modern pharmaceuticals and bioactive natural products. Three distinct chemical strategies are known in Nature to generate these structural motifs. The first is via the nucleophilic substitution at a prefunctionalized electrophilic carbon center with a halide anion (X- ), known for the S-adenosyl-l-methionine-dependent halogenases. The second is via the electrophilic activation of an alkene or its equivalent by a halenium ion (X+ ) donor, known for the haloperoxidases and flavin-dependent halogenases...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29776850/what-is-the-best-protocol-to-cryopreserve-immature-mouse-testicular-cell-suspensions
#7
Jaime Onofre, Katrien Faes, Prashant Kadam, Elena Vicini, Ans M M van Pelt, Ellen Goossens
RESEARCH QUESTION: From a clinical perspective, which parameters grant optimal cryopreservation of mouse testicular cell suspensions? DESIGN: We studied the effect of different cryopreservation rates, the addition of sugars, different vessels and the addition of an apoptotic inhibitor on the efficiency of testicular cell suspension cryopreservation. After thawing and warming, testicular cell suspensions were transplanted to recipient mice for further functional assay...
April 27, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29774177/the-new-direct-antiviral-agents-and-hepatitis-c-in-thoracic-transplantation-impact-on-donors-and-recipients
#8
REVIEW
Robert L Gottlieb, Shelley A Hall
Purpose of Review: The landscape of abdominal organ transplantation has been altered by the emergence of curative direct-acting antiviral agents for hepatitis C. Expansion of the thoracic donor pool to include the hearts and the lungs from hepatitis C-positive donors holds promise to increase available donor organs. Recent Findings: Case reports have documented separate lung and heart transplant patients who acquired, and then were cured of, donor-derived hepatitis C using these newer, more effective therapies...
2018: Current Transplantation Reports
https://www.readbyqxmd.com/read/29772386/novel-anticancer-hybrids-from-diazen-1-ium-1-2-diolate-nitric-oxide-donor-and-ros-inducer-plumbagin-design-synthesis-and-biological-evaluations
#9
Na Bao, Jinfeng Ou, Na Li, Pian Zou, Jianbo Sun, Li Chen
High levels of both nitric oxide (NO) and reactive oxygen species (ROS) could act as pro-apoptotic signals in cancerous cells. In this study, we conjugated diazeniumdiolates (NONOates), an important class of NO donors, with a natural occurring plumbagin (PL) which is primarily an excellent ROS inducer. Herein, a total of 12 novel plumbagin/NONOate hybrids have been synthesized and evaluated for their inhibitory effects on a panel of human cancer cell lines (MDA-MB-231, A549, HepG2 and HCT-116 cells) and two normal human cells (HK-2 and WRL-68 cells)...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29771491/modification-of-side-chains-of-conjugated-molecules-and-polymers-for-charge-mobility-enhancement-and-sensing-functionality
#10
Zitong Liu, Guanxin Zhang, Deqing Zhang
Organic semiconductors have received increasing attentions in recent years because of their promising applications in various optoelectronic devices. The key performance metric for organic semiconductors is charge carrier mobility, which is governed by the electronic structures of conjugated backbones and intermolecular/interchain π-π interactions and packing in both microscopic and macroscopic levels. For this reason, more efforts have been paid to the design and synthesis of conjugated frameworks for organic semiconductors with high charge mobilities...
May 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29769208/infusion-of-alloanergized-donor-lymphocytes-after-cd34-selected-haploidentical-myeloablative-hematopoietic-stem-cell-transplantation
#11
Jeff K Davies, Lisa L Brennan, John Wingard, Christopher R Cogle, Neena Kapoor, Ami J Shah, Bimalangshu R Dey, Thomas R Spitzer, Marcos De Lima, Laurence Jn Cooper, Peter Thall, Richard E Champlin, Lee M Nadler, Eva C Guinan
PURPOSE: Allogeneic haematopoietic stem-cell transplantation (HSCT) is a curative treatment for many haematologic cancers. Use of haploidentical (mismatched) donors increases HSCT availability but is limited by severe graft-versus-host disease (GvHD) and delayed immune reconstitution. Alloanergization of donor T-cells is a simple approach to rebuild immunity whilst limiting GvHD after haploidentical HSCT but the optimal T-cell dose and impact on immune reconstitution remain unknown.  Experimental Design: We performed a multicentre Phase 1 trial of alloanergized donor lymphocyte infusion (aDLI) after CD34-selected myeloablative haploidentical HSCT...
May 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29769179/rna-profiles-of-circulating-tumor-cells-and-extracellular-vesicles-for-therapy-stratification-of-metastatic-breast-cancer-patients
#12
Corinna Keup, Pawel Mach, Bahriye Aktas, Mitra Tewes, Hans-Christian Kolberg, Siegfried Hauch, Markus Sprenger-Haussels, Rainer Kimmig, Sabine Kasimir-Bauer
BACKGROUND: Liquid biopsies are discussed to provide surrogate markers for therapy stratification and monitoring. We compared messenger RNA (mRNA) profiles of circulating tumor cells (CTCs) and extracellular vesicles (EVs) in patients with metastatic breast cancer (MBC) to estimate their utility in therapy management. METHODS: Blood was collected from 35 hormone receptor-positive/HER2-negative patients with MBC at the time of disease progression and at 2 consecutive staging time points...
May 16, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29769007/qsar-and-docking-studies-on-piperidyl-cyclohexylurea-derivatives-for-prediction-of-selective-and-potent-inhibitor-of-matriptase
#13
Agha Zeeshan Mirza, Hina Shamshad
QSAR models as PLS, GFA, and 3D were developed for series of matriptase inhibitors using 35 piperidyl-cyclohexylurea compounds. The training and test sets were divided into a set of 28 and 8 compounds, respectively and the pki values of each compound were used in the analysis. Docking and alignment methodologies were used to develop models in 3D QSAR. The best models among all were selected on the basis of regression statistics as r2, predictive r2 and Friedman Lack of fit measure. Hydrogen donors and rotatable bonds were found to be positively correlated properties for this target...
May 16, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29768174/hiv-1-vaccines-based-on-antibody-identification-b-cell-ontogeny-and-epitope-structure
#14
REVIEW
Peter D Kwong, John R Mascola
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion surface. Antibodies isolated from HIV-1-infected donors, however, have been shown to recognize all major exposed regions of the prefusion-closed Env trimer, and an emerging understanding of the immunological and structural characteristics of these antibodies and the epitopes they recognize is enabling new approaches to vaccine design...
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29767983/reductive-radical-cascades-triggered-by-alkoxyl-radicals-in-the-%C3%AE-cyclodextrin-framework
#15
Elisa I León, Angeles Martín, Inés Pérez-Martín, Ernesto Suárez
The generation and fate of 2I-VII ,3I-VII ,6II-VII -icosa- O-methyl-β-cyclomaltoheptaos-6I - O-yl radical under reductive conditions is described. Two radical cascade reactions are involved: the main one is triggered by a 1,8-HAT of the hydrogen at 5VII C. The radical can reach the anomeric hydrogen at 1V C three sugar units ahead using a six-step sequence. The different hydrogen donor ability of the group 14 hydrides permits one to selectively stop the cascade at 5VII C, 2VI C, and 4VI C to obtain β-CD with a β-l-Ido p unit, acyclic hepta-, and hexa-saccharide structures, respectively...
May 16, 2018: Organic Letters
https://www.readbyqxmd.com/read/29766821/docking-and-3d-qsar-studies-on-substituted-cyclobutylphenyl-quinoline-derivatives-as-inhibitors-of-bacterial-dna-gyrase
#16
Rucha R Wani, Hemchandra K Chaudhari
Docking and 3D QSAR studies were performed on Inhibitor of Bacterial DNA gyrase to develop a predictive Common Pharmacophore Hypothesis (CPH) and use it for alignment in PHASE; with a diverse set of 58 bacterial DNA gyrase inhibitors. A five point CPH with H-bond acceptor(A), Hydrophobic (H), Hydrogen bond Donor(D), Aromatic ring(R), a basic or positively ionizable feature. From them, the best pharmacophore hypothesis AAAPR gives a statistically significant and 3D QSAR model with 0.92 as R-squared value and 0...
May 15, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29766775/deceased-donor-smoking-history-is-associated-with-increased-recipient-mortality-after-kidney-transplant-a-population-cohort-study
#17
Holly Gillott, Francesca Jackson Spence, Sanna Tahir, James Hodson, Jay Nath, Adnan Sharif
OBJECTIVES: Historical data have suggested that donor smoking is associated with detrimental clinical outcomes for recipients of kidneys from deceased donors. However, the effects of smoking status of a kidney donor on the outcomes of the recipient in a contemporary setting of immunosuppression and transplant practice have not yet been ascertained. MATERIALS AND METHODS: This retrospective, population-cohort study analyzed data of all deceased-donor kidney-alone transplant procedures performed in the United Kingdom between April 2001 and April 2013...
May 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29766160/on-the-relationship-between-the-structural-and-volumetric-properties-of-solvated-metal-ions-in-o-donor-solvents-using-new-structural-data-in-amide-solvents
#18
Daniel Lundberg, Dorota Warmińska, Anna Fuchs, Ingmar Persson
The structures of the N,N-dimethylformamide (dmf), N,N-dimethylacetamide (dma), and N,N-dimethylpropionamide (dmp) solvated strontium and barium ions have been determined in solution using large angle X-ray scattering and EXAFS spectroscopy. The strontium ion has a mean coordination number (CN) between 6.2 and 6.8, and the barium ion has a mean CN between 7.1 and 7.8 in these amide solvents. The non-integer numbers indicates that equilibria between different coordination numbers and geometries exist in these systems...
May 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29765587/variation-in-the-degree-of-reciprocal-herkogamy-affects-the-degree-of-legitimate-pollination-in-a-distylous-species
#19
Xian-Feng Jiang, Xing-Fu Zhu, Qing-Jun Li
Distyly is a widespread floral polymorphism characterized by the flowers within a population showing reciprocal placement of the anthers and stigma. Darwin hypothesizes that distyly evolves to promote precise pollen transfer between morphs. Primula chungensis exhibits two types of anther heights, and these two types of anthers show pollen of two different size classes. To understand whether the stigma could capture more pollen grains from the anthers of the pollen donor as the separation between the stigma of pollen receiver and the anther of pollen donor decreased, the present research assessed the source of the pollen load in a series of open-pollinated flowers with continuous variation of style lengths...
June 2018: AoB Plants
https://www.readbyqxmd.com/read/29765294/which-infectious-blood-donors-could-be-identified-by-the-donor-history-questionnaire-comparison-of-blood-donors-infected-with-hiv-or-hcv-with-notified-cases-from-general-population-in-germany
#20
Karina Preußel, Ruth Offergeld
Background: Potential risks for transfusion-transmissible infections are identified by donor history questionnaires (DHQs), and donors with higher risks are deferred from donation. We assessed to which extent the currently used DHQs support the identification of infections among blood donors. Methods: Between 2006 and 2013, we analyzed data from notified HIV and HCV cases in the general population and positive blood donors in Germany. Logistic regressions were used to identify relevant infection risks...
April 2018: Transfusion Medicine and Hemotherapy
keyword
keyword
82752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"