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https://www.readbyqxmd.com/read/28942639/mechanistic-basis-for-efficient-site-selective-aerobic-catalytic-turnover-in-pd-catalyzed-c-h-imidoylation-of-heterocycle-containing-molecules
#1
Stephen J Tereniak, Shannon S Stahl
A recently reported Pd-catalyzed oxidative C-H imidoylation of N-methoxybenzamides to iminoisoindolinones with tBuNC exhibits a number of unique features that have important implications for Pd-catalyzed aerobic oxidation catalysis: (1) The reaction tolerates heterocycles that commonly poison PdII oxidation catalysts. (2) The site selectivity of C-H activation is controlled by an N-methoxyamide group in the substrate rather than a suitably positioned heterocycle. (3) A Pd0 source, Pd2(dba)3 (dba = dibenzylideneacetone), is superior to Pd(OAc)2 as a precatalyst, and other PdII sources [PdCl2, Pd(TFA)2, Pd(OTf)2] are ineffective (TFA = trifluoroacetate, OTf = trifluoromethanesulfonate)...
September 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28942506/production-of-tiger-puffer-takifugu-rubripes-offspring-from-triploid-grass-puffer-takifugu-niphobles-parents
#2
Masaomi Hamasaki, Yutaka Takeuchi, Ryosuke Yazawa, Souta Yoshikawa, Kazushi Kadomura, Toshiyuki Yamada, Kadoo Miyaki, Kiyoshi Kikuchi, Goro Yoshizaki
The tiger puffer Takifugu rubripes is one of the most popular aquacultural fish; however, there are two major obstacles to selective breeding. First, they have a long generation time of 2 or 3 years until maturation. Second, the parental tiger puffer has a body size (2-5 kg) much larger than average market size (0.6-1.0 kg). The grass puffer Takifugu niphobles is closely related to the tiger puffer and matures in half the time. Furthermore, grass puffer can be reared in small areas since their maturation weight is about 1/150 that of mature tiger puffer...
September 23, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28940946/islet-neuropeptide-y-receptors-are-functionally-conserved-and-novel-targets-for-the-preservation-of-beta-cell-mass
#3
Z J Franklin, A Tsakmaki, P Fonseca Pedro, A J King, G C Huang, S J Persaud, G A Bewick
OBJECTIVE: Two unmet therapeutic strategies for diabetes treatment are prevention of beta-cell death and stimulation of beta-cell replication. Our aim was to characterise the role of Neuropeptide Y receptors in the control of beta-cell mass. METHODS: We used endogenous and selective agonists of the NPY receptor system to explore its role in the prevention of beta-cell apoptosis and proliferation in islets isolated from both mouse and human donors. We further explored the intra-cellular signalling cascades involved using chemical inhibitors of key signalling pathways...
September 22, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28940887/association-of-hla-polymorphisms-with-occult-hepatitis-b-virus-infection-in-shaanxi-han-population
#4
Tianju Wang, Chunmei Shen, Liping Chen, Sheng Liu, Yanhong Ji
BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) is defined as HBV DNA detection in serum or in the liver by sensitive diagnostic tests in HBsAg negative patients with or without serologic markers of previous HBV exposure. Since the human leukocyte antigen (HLA) system is an integral component of the immune response, we hypothesized that the highly polymorphic HLA genes were the key determinants of HBV persistence and clearance. The aim of the study was to calculate the allelic frequency of HLA loci and investigate the association between HLA alleles and the outcome of OBI in Shaanxi Han populations in the northwest of China...
September 20, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28940842/an-unsymmetrical-squaraine-dye-based-chemical-platform-for-multiple-analyte-recognition
#5
Ayyappanpillai Ajayaghosh, Divya Susan Philips, Samrat Ghosh, Karivachery V Sudheesh, Cherumuttathu H Suresh
Design of fluorescent molecular platforms capable of responding to multiple analytes is a topic of great interest. Herein, we report the use of a Zn2+-complexed unsymmetrical squaraine dye, Sq-Zn2+ as a chemical platform for recognizing structurally distinct analytes. The squaraine ring is substituted on one side with a dipicolylamine unit which acts as the metal ion receptor while the other part of the molecule carries a dibutyl aniline moiety which is an electron donor. The molecular system is unique as it could respond specifically to different types of analytes viz atmospheric carbon dioxide, cyclic phosphates and picric acid...
September 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28940540/successful-kidney-transplantation-in-a-patient-with-congenital-thrombotic-thrombocytopenic-purpura-upshaw-schulman-syndrome
#6
Hasan Fattah, Dhiren Kumar, James N George, H Davis Massey, Anne L King, Kenneth D Friedman, Gaurav Gupta
BACKGROUND: Congenital thrombotic thrombocytopenic purpura (TTP) may not be recognized until organ failure related to the microvascular thrombosis occurs. Kidney failure may be the initial presenting clinical feature. Kidney transplantation has been contraindicated because of the assumption that the continuing microvascular thrombosis will cause inevitable graft failure. CASE REPORT: We report a 48-year-old nulliparous woman who presented with end-stage kidney disease that was attributed to hypertension...
September 20, 2017: Transfusion
https://www.readbyqxmd.com/read/28938860/pharmacophore-generation-atom-based-3d-qsar-molecular-docking-and-molecular-dynamics-simulation-studies-on-benzamide-analogues-as-ftsz-inhibitors
#7
Swayansiddha Tripathy, Mohammed Afzal Azam, Srikanth Jupudi, Susanta Kumar Sahu
FtsZ is an appealing target for the design of antimicrobial agent that can be used to defeat the multidrug-resistant (MDR) bacterial pathogens. Pharmacophore modelling, molecular docking, and molecular dynamics (MD) simulation studies were performed on a series of 3-substituted benzamide derivatives. In the present study a five-featured pharmacophore model with one hydrogen bond acceptors (A), one hydrogen bond donors (D), one hydrophobic (H) and two aromatic rings (RR) was developed using 97 molecules having MIC values ranging from 0...
September 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28938416/pancreatic-histopathology-of-human-monogenic-diabetes-due-to-causal-variants-in-kcnj11-hnf1a-gata6-and-lmna
#8
May Sanyoura, Laura Jacobsen, David Carmody, Daniela Del Gaudio, Gorka Alkorta-Aranburu, Kelly Arndt, Ying Ying Hu, Frances Kobiernicki, Irina Kusmartseva, Mark A Atkinson, Louis H Philipson, Desmond Schatz, Martha Campbell-Thompson, Siri Atma W Greeley
Context: Monogenic diabetes is thought to account for 2% of all diabetes cases but most patients are misdiagnosed as type 1 or type 2 diabetes. To date, little is known about the histopathological features of pancreases from patients with monogenic diabetes. Objective: Retrospective study of the JDRF Network for Pancreatic Organ donors with Diabetes biorepository was used to identify possible cases with monogenic diabetes and to compare effects of genetic variants on pancreas histology...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937364/nucleic-acid-amplification-testing-in-indian-blood-banks-a-review-with-perspectives
#9
Kanjaksha Ghosh, Kanchan Mishra
BACKGROUND: Nucleic acid amplification testing (NAT) is restricted to a few blood banks in India since 2008. This review was directed toward understanding NAT yield in different parts of the country and prevalence in the NAT of different types of virus. MATERIALS AND METHODS: English literature was searched from 1990 to 2016 in PubMed, Scopus, Ind med, and Google database using properly constructed key words. Literature was collected and finally the data were synthesized...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936819/-the-scope-quality-and-safety-requirements-of-drug-abuse-testing
#10
Tuncay Küme, Çiğdem Karakükcü, Aslı Pınar, Hakan Coşkunol
The aim of this review is to inform about the scopes and requirements of drug abuse testing. Drug abuse testing is one of the tools for determination of drug use. It must fulfill the quality and safety requirements in judgmental legal and administrative decisions. Drug abuse testing must fulfill some requirements like selection of the appropriate test matrix, appropriate screening test panel, sampling in detection window, patient consent, identification of the donor, appropriate collection site, sample collection with observation, identification and control of the sample, specimen custody chain in preanalytical phase; analysis in authorized laboratories, specimen validity tests, reliable testing METHODS, strict quality control, two-step analysis in analytical phase; storage of the split specimen, confirmation of the split specimen in the objection, result custody chain, appropriate cut-off concentration, the appropriate interpretation of the result in postanalytical phase...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936496/h-pylori-%C3%AE-1-3-4-fucosyltransferase-hp3-4ft-catalyzed-one-pot-multienzyme-opme-synthesis-of-lewis-antigens-and-human-milk-fucosides
#11
Hai Yu, Yanhong Li, Zhigang Wu, Lei Li, Jie Zeng, Chao Zhao, Yijing Wu, Nova Tasnima, Jing Wang, Huaide Liu, Madhusudhan Reddy Gadi, Wanyi Guan, Peng G Wang, Xi Chen
Helicobacter pylori α1-3/4-fucosyltransferase (Hp3/4FT) was expressed in Escherichia coli at a level of 30 mg L(-1) culture and used as a diverse catalyst in a one-pot multienzyme (OPME) system for high-yield production of l-fucose-containing carbohydrates including Lewis antigens such as Lewis a, b, and x, O-sulfated Lewis x, and sialyl Lewis x and human milk fucosides such as 3-fucosyllactose (3-FL), lacto-N-fucopentaose (LNFP) III, and lacto-N-difuco-hexaose (LNDFH) II and III. Noticeably, while difucosylation of tetrasaccharides was readily achieved using an excess amount of donor, the synthesis of LNFP III was achieved by Hp3/4FT-catalyzed selective fucosylation of the N-acetyllactosamine (LacNAc) component in lacto-N-neotetraose (LNnT)...
September 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28935102/biosynthesis-of-legionaminic-acid-and-its-incorporation-into-glycoconjugates
#12
Ian C Schoenhofen, N Martin Young, Michel Gilbert
Legionaminic acids are analogs of sialic acid that occur in cell surface glycoconjugates of several bacteria. Because legionaminic acids share the same stereochemistry as sialic acid but differ at C7 and C9, they are interesting analogs to probe the impact of varying exocyclic moieties (C7-C9) on biological activities such as susceptibilities to sialidases, interactions with Siglecs and immunogenicity. There are currently no reports on the bacterial enzymes that transfer legionaminic acids to these cell surface glycoconjugates, but some mammalian and bacterial sialyltransferases display donor promiscuity and can use CMP-Leg5,7Ac2 efficiently enough to transfer Leg5,7Ac2 to their natural acceptor glycans...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28934518/acute-hemolytic-transfusion-reaction-caused-by-a-red-cell-antibody-that-was-missed-by-pretransfusion-testing-using-tube-method
#13
Aaron Shmookler, Diane Hamad, Scott Scrape, Jian Chen
Pretransfusion testing is very important to prevent transfusion of incompatible red cells, which might result in a hemolytic transfusion reaction. This includes the detection of antibodies in recipients' serum and compatibility testing between donor cells and recipient serum. The most commonly used methods include gel and tube techniques. We present a case in which an anti-E alloantibody was detected by gel method but not by tube testing. As a result, red cells that were retrospectively phenotyped as positive for E antigen were inadvertently selected and transfused after crossmatch using the same tube method...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28933841/supramolecular-self-assembly-and-dual-switch-vapochromic-vapoluminescent-and-resistive-memory-behaviors-of-amphiphilic-platinum-ii-complexes
#14
Yongguang Li, Ling Chen, Yeye Ai, Eugene Yau-Hin Hong, Alan Kwun-Wa Chan, Vivian Wing-Wah Yam
A series of amphiphilic platinum(II) complexes with tridentate N-donor ligands has been synthesized and characterized. Different supramolecular architectures are constructed using the amphiphilic molecules as the building blocks through the formation of Pt···Pt and π-π stacking interactions in aqueous media. The aggregation-deaggregation-aggregation self-assembly behavior together with obvious spectroscopic changes could be fine-tuned by the addition of THF in aqueous media. More interestingly, one of the complexes is found to show fast response and high selectivity toward alcohol and water vapors with good reversibility, leading to drastic color and luminescence changes, and hence unique dual switching behavior, with the water molecules readily displaced by the alcohol vapor...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933827/three-cadmium-coordination-polymers-with-carboxylate-and-pyridine-mixed-ligands-luminescent-sensors-for-fe-iii-and-cr-vi-ions-in-an-aqueous-medium
#15
Yanna Lin, Xiaoping Zhang, Wenjie Chen, Wei Shi, Peng Cheng
Three new water-stable luminescent Cd(II) coordination polymers (CPs), {[Cd2(bptc)(2,2'-bipy)2(H2O)2]}n (1), {[Cd2(bptc)(phen)2]·4H2O}n (2), and {[Cd2(bptc)(4,4'-bipy)(H2O)2]·4H2O}n (3), were solvothermally synthesized with mixed ligands of 3,3',5,5'-biphenyltetracarboxylic acid (H4bptc) and N-donor ligands (2,2'-bipy = 2,2'-bipyridine; phen = 1,10-phenanthroline; 4,4'-bipy = 4,4'-bipyridine). The CPs 1-3 show structural diversity from a 1D ladder chain to a 2D layer to a 3D porous framework, tuned by different ancillary ligands...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28931929/a-resource-of-large-scale-molecular-markers-for-monitoring-agropyron-cristatum-chromatin-introgression-in-wheat-background-based-on-transcriptome-sequences
#16
Jinpeng Zhang, Weihua Liu, Yuqing Lu, Qunxing Liu, Xinming Yang, Xiuquan Li, Lihui Li
Agropyron cristatum is a wild grass of the tribe Triticeae and serves as a gene donor for wheat improvement. However, very few markers can be used to monitor A. cristatum chromatin introgressions in wheat. Here, we reported a resource of large-scale molecular markers for tracking alien introgressions in wheat based on transcriptome sequences. By aligning A. cristatum unigenes with the Chinese Spring reference genome sequences, we designed 9602 A. cristatum expressed sequence tag-sequence-tagged site (EST-STS) markers for PCR amplification and experimental screening...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931910/the-role-of-charge-balance-and-excited-state-levels-on-device-performance-of-exciplex-based-phosphorescent-organic-light-emitting-diodes
#17
Sangyeob Lee, Hyun Koo, Ohyun Kwon, Young Jae Park, Hyeonho Choi, Kwan Lee, Byungmin Ahn, Young Min Park
The design of novel exciplex-forming co-host materials provides new opportunities to achieve high device performance of organic light emitting diodes (OLEDs), including high efficiency, low driving voltage and low efficiency roll-off. Here, we report a comprehensive study of exciplex-forming co-host system in OLEDs including the change of co-host materials, mixing composition of exciplex in the device to improve the performance. We investigate various exciplex systems using 5-(3-4,6-diphenyl-1,3,5-triazin-2-yl)phenyl-3,9-diphenyl-9H-carbazole, 5-(3-4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-9-phenyl-9H-3,9'-bicarbazole, and 2-(3-(6,9-diphenyl-9H-carbazol-4-yl)phenyl)-4-phenylbenzo[4,5]thieno[3,2-d]pyrimidine, as electron transporting (ET: electron acceptor) hosts and 9,9'-dipenyl-9H, 9'H-3,3'-bicarbazole and 9-([1,1'-biphenyl]-4-yl)-9'-phenyl-9H,9'H-3,3'-bicarbazole as hole transporting (HT: electron donor) hosts...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931278/fluorescence-resonance-energy-transfer-based-dna-nanoprism-with-a-split-aptamer-for-atp-sensing-in-living-cells
#18
Xiaofang Zheng, Ruizi Peng, Xi Jiang, Yaya Wang, Shuai Xu, Guoliang Ke, Ting Fu, Qiaoling Liu, Shuang-Yan Huan, Xiaobing Zhang
We have developed a DNA nanoprobe for adenosine triphosphate (ATP) sensing in living cells, based on the split aptamer and the DNA triangular prism (TP). In which nucleic acid aptamer was split into two fragments, the stem of the split aptamer was respectively labeled donor and acceptor fluorophores that underwent an fluorescence resonance energy transfer if two ATP molecules were bound as target molecule to the recognition module. Hence, ATP as a target induced the self-assembly of split aptamer fragments and thereby brought the dual fluorophores into close proximity for high FRET efficiency...
September 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28931074/genetic-and-phenotypic-effects-of-chromosome-segments-introgressed-from-gossypium-barbadense-into-gossypium-hirsutum
#19
Weiwu Song, Mi Wang, Wei Su, Quanwei Lu, Xianghui Xiao, Juan Cai, Zhen Zhang, Shaoqi Li, Pengtao Li, Juwu Gong, Wankui Gong, Haihong Shang, Aiying Liu, Junwen Li, Tingting Chen, Qun Ge, Yuzhen Shi, Youlu Yuan
MBI9915 is an introgression cotton line with excellent fiber quality. It was obtained by advanced backcrossing and continuous inbreeding from an interspecific cross between the upland cotton (Gossypium hirsutum) cultivar CCRI36 as the recurrent parent and the sea island cotton (G. barbadense) cultivar Hai1, as the donor parent. To study the genetic effects of the introgressed chromosome segments in G. hirsutum, an F2 secondary segregating population of 1537 individuals was created by crossing MBI9915 and CCRI36, and an F2:3 population was created by randomly selecting 347 individuals from the F2 generation...
2017: PloS One
https://www.readbyqxmd.com/read/28930976/detection-of-residual-donor-erythroid-progenitor-cells-after-hematopoietic-stem-cell-transplantation-for-patients-with-hemoglobinopathies
#20
Roman Crazzolara, Gabriele Kropshofer, Michael Steurer, Sieghart Sopper, Wolfgang Schwinger
The presence of incomplete chimerism is noted in a large proportion of patients following bone marrow transplant for thalassemia major or sickle cell disease. This observation has tremendous implications, as subsequent therapeutic immunomodulation strategies can improve clinical outcome. Conventionally, polymerase chain reaction-based analysis of short tandem repeats is used to identify chimerism in donor-derived blood cells. However, this method is restricted to nucleated cells and cannot distinguish between dissociated single-cell lineages...
September 6, 2017: Journal of Visualized Experiments: JoVE
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