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Reactive hypoxia index

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https://www.readbyqxmd.com/read/27913427/intermittent-hypoxia-during-recovery-from-neonatal-hyperoxic-lung-injury-causes-long-term-impairment-of-alveolar-development-a-new-rat-model-of-bpd
#1
Anastasiya Mankouski, Crystal Kantores, Mathew J Wong, Julijana Ivanovska, Amish Jain, Eric J Benner, Stanley N Mason, A Keith Tanswell, Richard L Auten, Robert P Jankov
Bronchopulmonary dysplasia (BPD) is a chronic lung injury characterized by impaired alveologenesis that may persist into adulthood. Rat models of BPD using varying degrees of hyperoxia to produce injury either cause early mortality or spontaneously recover following removal of the inciting stimulus, thus limiting clinical relevance. We sought to refine an established rat model induced by exposure to 60% O2 from birth by following hyperoxia with intermittent hypoxia (IH). Rats exposed from birth to air or 60% O2 until day 14 were recovered in air with or without IH (FiO2 = 0...
December 2, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27844208/sirtuins-1-7-expression-in-human-adipose-derived-stem-cells-from-subcutaneous-and-visceral-fat-depots-influence-of-obesity-and-hypoxia
#2
Stefania Mariani, Giuliana Di Rocco, Gabriele Toietta, Matteo A Russo, Elisa Petrangeli, Luisa Salvatori
The sirtuin family comprises seven NAD(+)-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways. Sirtuins are important modulators of adipose tissue metabolism and their expression is higher in lean than obese subjects. At present, the role of sirtuins in adipose-derived stem cells has not been investigated yet. Therefore, in this study, we evaluated the expression of the complete panel of sirtuins in adipose-derived stem cells isolated from both subcutaneous and visceral fat of non-obese and obese subjects...
November 14, 2016: Endocrine
https://www.readbyqxmd.com/read/27699083/oxidative-stress-induced-telomere-length-shortening-of-circulating-leukocyte-in-patients-with-obstructive-sleep-apnea
#3
Kyung Soo Kim, Jin Wook Kwak, Su Jin Lim, Yong Kyun Park, Hoon Shik Yang, Hyun Jik Kim
The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden of oxidative stress during sleep. We aimed to search the predictive markers which reflect the burden of systemic oxidative stress in patients with OSA and whether excessive telomere length shortening is a characteristic feature that can assess oxidative stress levels. We used quantitative PCR to measure telomere length using peripheral blood genomic DNA...
October 2016: Aging and Disease
https://www.readbyqxmd.com/read/27501738/nocturnal-hypoxia-induced-oxidative-stress-promotes-progression-of-pediatric-non-alcoholic-fatty-liver-disease
#4
Shikha S Sundaram, Ann Halbower, Zhaoxing Pan, Kristen Robbins, Kelley E Capocelli, Jelena Klawitter, Colin T Shearn, Ronald J Sokol
BACKGROUND & AIMS: Oxidative stress is proposed as a central mediator in NAFLD pathogenesis, but the specific trigger for reactive oxygen species generation has not been clearly delineated. In addition, emerging evidence shows that obesity related obstructive sleep apnea (OSA) and nocturnal hypoxia are associated with NAFLD progression in adults. The aim of this study was to determine if OSA/nocturnal hypoxia-induced oxidative stress promotes the progression of pediatric NAFLD. METHODS: Subjects with biopsy proven NAFLD and lean controls were studied...
September 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27445853/inflammatory-role-of-ros-sensitive-amp-activated-protein-kinase-in-the-hypersensitivity-of-lung-vagal-c-fibers-induced-by-intermittent-hypoxia-in-rats
#5
Chang-Huan Yang, Yan-Jhih Shen, Ching Jung Lai, Yu Ru Kou
Obstructive sleep apnea (OSA), manifested by airway exposure to intermittent hypoxia (IH), is associated with excess reactive oxygen species (ROS) production in airways, airway inflammation, and hyperreactive airway diseases. The cause-effect relationship for these events remains unclear. We investigated the inflammatory role of ROS-sensitive AMP-activated protein kinase (AMPK) in IH-induced airway hypersensitivity mediated by lung vagal C fibers (LVCFs) in rats. Conscious rats were exposed to room air (RA) or IH with or without treatment with N-acetyl-L-cysteine (NAC, an antioxidant), Compound C (an AMPK inhibitor), ibuprofen (a cyclooxygenase inhibitor), or their vehicles...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27415798/evaluation-of-vitamin-c-supplementation-on-kidney-function-and-vascular-reactivity-following-renal-ischemic-injury-in-mice
#6
Yao-Bin Zhu, Ya-Ping Zhang, Jing Zhang, Yan-Bo Zhang
BACKGROUND/AIMS: Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS: IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced glutathione (GSH), total reactive oxygen species (ROS) level and superoxide dismutase (SOD) were examined...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27356574/effectiveness-of-sodium-dichloroacetate-against-glioma-c6-depends-on-administration-schedule-and-dosage
#7
A G Fedorchuk, O N Pyaskovskaya, G V Gorbik, I V Prokhorova, D L Kolesnik, G I Solyanik
BACKGROUND: Anticancer action of sodium dichloroacetate (DCA) could be related to its ability to activate oxidative phosphorylation leading to enhanced generation of reactive oxygen species and induction of apoptosis. On the other hand, activation of oxidative phosphorylation could promote tumor cell survival, in particular, via increased ATP synthesis. Such ambiguous effects of DCA could influence its anticancer effectiveness, depending on biological properties of a tumor, schedule of DCA administration and its dosage...
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27281472/increased-cardiometabolic-risk-and-worsening-hypoxemia-at-high-altitude
#8
Catherine H Miele, Alan R Schwartz, Robert H Gilman, Luu Pham, Robert A Wise, Victor G Davila-Roman, Jonathan C Jun, Vsevolod Y Polotsky, J Jaime Miranda, Fabiola Leon-Velarde, William Checkley
Miele, Catherine H., Alan R. Schwartz, Robert H. Gilman, Luu Pham, Robert A. Wise, Victor G. Davila-Roman, Jonathan C. Jun, Vsevolod Y. Polotsky, J. Jaime Miranda, Fabiola Leon-Velarde, and William Checkley. Increased cardiometabolic risk and worsening hypoxemia at high altitude. High Alt Med Biol. 17:93-100, 2016.-Metabolic syndrome, insulin resistance, diabetes, and dyslipidemia are associated with an increased risk of cardiovascular disease. While excessive erythrocytosis is associated with cardiovascular complications, it is unclear how worsening hypoxemia of any degree affects cardiometabolic risk factors in high-altitude populations...
June 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27242540/nadph-oxidase-derived-ros-induced-by-chronic-intermittent-hypoxia-mediates-hypersensitivity-of-lung-vagal-c-fibers-in-rats
#9
Chang-Huan Yang, Wei-Ling Zhuang, Yan-Jhih Shen, Ching Jung Lai, Yu Ru Kou
Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which may contribute to airway hypersensitivity pathogenesis. We investigated whether CIH augments the reflex and afferent responses of LVCFs to chemical stimulants and the roles of ROS and NADPH oxidase in such airway hypersensitivity...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27225949/cerebral-blood-flow-regulation-in-women-across-menstrual-phase-differential-contribution-of-cyclooxygenase-to-basal-hypoxic-and-hypercapnic-vascular-tone
#10
Garrett L Peltonen, John W Harrell, Benjamin P Aleckson, Kaylie M LaPlante, Meghan K Crain, William G Schrage
In healthy young women, basal cerebral blood flow (CBF) and cerebrovascular reactivity may change across the menstrual cycle, but mechanisms remain untested. When compared with the early follicular phase of the menstrual cycle, we hypothesized women in late follicular phase would exhibit: 1) greater basal CBF, 2) greater hypercapnic increases in CBF, 3) greater hypoxic increases in CBF, and 4) increased cyclooxygenase (COX) signaling. We measured middle cerebral artery velocity (MCAv, transcranial Doppler ultrasound) in 11 healthy women (23 ± 1 yr) during rest, hypoxia, and hypercapnia...
August 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27139126/prognostic-value-of-blood-biomarkers-related-to-hypoxia-inflammation-immune-response-and-tumour-load-in-non-small-cell-lung-cancer-a-survival-model-with-external-validation
#11
Sara Carvalho, Esther G C Troost, Judith Bons, Paul Menheere, Philippe Lambin, Cary Oberije
AIM: Improve the prognostic prediction of clinical variables for non-small cell lung cancer (NSCLC), by selecting from blood-biomarkers, non-invasively describing hypoxia, inflammation and tumour load. METHODS: Model development and validation included 182 and 181 inoperable stage I-IIIB NSCLC patients treated radically with radiotherapy (55.2%) or chemo-radiotherapy (44.8%). Least absolute shrinkage and selection operator (LASSO), selected from blood-biomarkers related to hypoxia [osteopontin (OPN) and carbonic anhydrase IX (CA-IX)], inflammation [interleukin-6 (IL-6), IL-8, and C-reactive protein (CRP)], and tumour load [carcinoembryonic antigen (CEA), and cytokeratin fragment 21-1 (Cyfra 21-1)]...
June 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26995743/effects-of-hypoxia-and-reoxygenation-on-the-antioxidant-defense-system-of-the-locomotor-muscle-of-the-crab-neohelice-granulata-decapoda-varunidae
#12
Márcio Alberto Geihs, Marcelo Alves Vargas, Fábio Everton Maciel, Olli Vakkuri, Victor Benno Meyer-Rochow, Silvana Allodi, Luiz Eduardo Maia Nery
Crustaceans often occur in areas with variations in oxygen and experience situations known as hypoxia and reoxygenation. Consequences of such situations are increased levels of reactive oxygen species. To avoid oxidative damage intertidal crabs appear to possess an efficient antioxidant defense system (ADS). However, to date, studies have not addressed the strategies that are adopted by the crabs when exposed to hypoxia/reoxygenation cycles. Towards this end we evaluated the ADS and the role of melatonin as an antioxidant in the locomotor muscle of the crab Neohelice granulata under conditions of severe hypoxia and reoxygenation...
July 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/26993342/effect-of-cpap-therapy-on-c-reactive-protein-and-cognitive-impairment-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#13
Shu Qing Wu, Qing Chi Liao, Xing Xiang Xu, Li Sun, Jing Wang, Rui Chen
PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with neurocognitive impairment. We examined the role of the systemic inflammatory response, measured by high-sensitivity C-reactive protein (hsCRP) assay, and the effect of CPAP treatment on hsCRP and cognitive impairment in patients with OSAHS. METHODS: Eligible subjects (n = 178) were categorized into two groups: absent or mild OSAHS, and moderate to severe OSAHS. First, the Montreal Cognitive Assessment (MoCA) and serum hsCRP concentration were measured...
March 18, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/26937636/early-diagnosis-of-pneumonia-in-severe-stroke-clinical-features-and-the-diagnostic-role-of-c-reactive-protein
#14
Anushka Warusevitane, Dumin Karunatilake, Julius Sim, Craig Smith, Christine Roffe
BACKGROUND: Accurate diagnosis of pneumonia complicating severe stroke is challenging due to difficulties in physical examination, altered immune responses and delayed manifestations of radiological changes. The aims of this study were to describe early clinical features and to examine C-reactive protein (CRP) as a diagnostic marker of post-stroke pneumonia. METHODS: Patients who required nasogastric feeding and had no evidence of pneumonia within 7 days of stroke onset were included in the study and followed-up for 21 days with a daily clinical examination...
2016: PloS One
https://www.readbyqxmd.com/read/26811929/observational-study-of-obstructive-sleep-apnea-in-wake-up-stroke-the-sleep-tight-study
#15
Brian B Koo, Daawn M Bravata, Lauren A Tobias, Jason S Mackey, Edward J Miech, Marianne S Matthias, Stephanie M Stahl, Jason J Sico, Carlos A Vaz Fragoso, Linda S Williams, Rachel Lampert, Li Qin, Henry Klar Yaggi
BACKGROUND: Wake-up stroke (WUS) accounts for a quarter of all ischemic strokes. Its conspicuous occurrence during sleep suggests that WUS may be associated with obstructive sleep apnea (OSA). We investigated the potential association among WUS, OSA, and measures of sympathetic hyperactivity. METHODS: This is a cross-sectional analysis of data from the Sleep Apnea in Transient Ischemic Attack and Stroke (SLEEP TIGHT) study. Ischemic stroke patients were divided into WUS and non-WUS groups...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26568619/placental-programmed-cell-death-insights-into-the-role-of-aquaporins
#16
N Szpilbarg, M Castro-Parodi, J Reppetti, M Repetto, B Maskin, N Martinez, A E Damiano
STUDY HYPOTHESIS: Are the placental aquaporins (AQPs) involved in the apoptosis of human trophoblast? STUDY FINDING: The general blocking of placental AQPs with HgCl2 and, in particular, the blocking of AQP3 activity with CuSO4 abrogated the apoptotic events of human trophoblast cells. WHAT IS KNOWN ALREADY: Although apoptosis of trophoblast cells is a natural event involved in the normal development of the placenta, it is exacerbated in pathological processes, such as pre-eclampsia, where an abnormal expression and functionality of placental AQPs occur without alterations in the feto-maternal water flux...
January 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/26542522/measuring-the-human-ventilatory-and-cerebral-blood-flow-response-to-co2-a-technical-consideration-for-the-end-tidal-to-arterial-gas-gradient
#17
Michael M Tymko, Ryan L Hoiland, Tomas Kuca, Lindsey M Boulet, Joshua C Tremblay, Bryenna K Pinske, Alexandra M Williams, Glen E Foster
Our aim was to quantify the end-tidal-to-arterial gas gradients for O2 (PET-PaO2) and CO2 (Pa-PETCO2) during a CO2 reactivity test to determine their influence on the cerebrovascular (CVR) and ventilatory (HCVR) response in subjects with (PFO+, n = 8) and without (PFO-, n = 7) a patent foramen ovale (PFO). We hypothesized that 1) the Pa-PETCO2 would be greater in hypoxia compared with normoxia, 2) the Pa-PETCO2 would be similar, whereas the PET-PaO2 gradient would be greater in those with a PFO, 3) the HCVR and CVR would be underestimated when plotted against PETCO2 compared with PaCO2, and 4) previously derived prediction algorithms will accurately target PaCO2...
January 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/26387470/serum-cxcl12-levels-on-hospital-admission-predict-mortality-in-patients-with-severe-sepsis-septic-shock
#18
Stefano Franchini, Teodoro Marcianò, Cristina Sorlini, Corrado Campochiaro, Moreno Tresoldi, Maria Grazia Sabbadini, Lorenzo Dagna
OBJECTIVES: We evaluated serum levels of CXCL12 in patients with severe sepsis/septic shock and controls. METHODS: We enrolled 27 patients admitted to our emergency department with severe sepsis/septic shock and 20 healthy controls. Complete blood count, serum levels of CXCL12, C-reactive protein, lactate, Charlson comorbidity index, sequential organ failure score on hospital admission, and inhospital mortality were evaluated at baseline (T0) and after 24 hours (T24)...
December 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26359028/-the-effects-of-continuous-positive-airway-pressure-ventilation-on-hypersensitive-c-reaction-protein-and-8-isoprostane-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#19
Jin Qian, Xiaorong Ma, Lei Pan, Zhenning Zhang, Yali Xu, Yong Wang
OBJECTIVE: To observe the effect of continuous positive airway pressure ventilation on hypersensitive C reaction protein (hsCRP) and 8-isoprostane in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: A total of 78 OSAHS patients were enrolled and monitored by polysomnography (PSG) in January to March, 2013. Another 40 healthy persons were chosen as controls during the same time. According to apnea hypopnea index (AHI) and oxygen saturation, the patients were divided into mild, moderate and severe groups...
July 2015: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/26186298/heart-fat-infiltration-in-subjects-with-and-without-coronary-artery-disease
#20
Gloria Mazzali, Francesco Fantin, Elena Zoico, Anna Sepe, Clara Bambace, Silvia Faccioli, Martina Pedrotti, Francesca Corzato, Vanni Rizzatti, Giuseppe Faggian, Rocco Micciolo, Saverio Cinti, Francesco Santini, Mauro Zamboni
CONTEXT: Fat may accumulate around the heart in epicardial adipose tissue or inside the heart as lipid droplets (LDs). OBJECTIVE: To compare myocardial steatosis between subjects with and without coronary artery disease (CAD and non-CAD) and to identify which cells contain LDs. DESIGN: Body mass index, waist circumference, glucose, insulin, homeostasis model assessment index, leptin, adiponectin, and high-sensitivity C-reactive protein were evaluated in CAD and non-CAD subjects...
September 2015: Journal of Clinical Endocrinology and Metabolism
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