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(Tatli MM)

Richard Cheng, Emily Tat, Robert J Siegel, Reza Arsanjani, Asma Hussaini, Moody Makar, Yukiko Mizutani, Alfredo Trento, Saibal Kar
AIMS: Mitral annular calcification (MAC) negatively influences outcomes in surgical mitral valve (MV) repair for mitral regurgitation (MR). However, there are no data on whether MAC impacts on outcomes of MitraClip percutaneous MV edge-to-edge repair. This study sought to investigate whether the presence of MAC impacts on the procedural success and durability of percutaneous transcatheter repair of MR using the MitraClip. METHODS AND RESULTS: One hundred and seventy-three patients undergoing MitraClip repair for significant MR were studied...
October 20, 2016: EuroIntervention
Yao Li, Feng Cao, Tat Thang Vo Doan, Hirotaka Sato
The mechanisms and principles of insect flight have long been investigated by researchers working on micro and nano air vehicles (MAVs/NAVs). However, studies of insect flight maneuvers require high speed filming and high spatial resolution in a small experimental space, or the tethering of the insect to a fixed place. Under such artificial conditions, the insects may deviate its flying behavior from that of regular flight. In this study, we mounted a tiny wireless system, or 'backpack', on live beetles (Mecynorrhina torquata; length 62 ± 8 mm; mass 7...
2016: Bioinspiration & Biomimetics
Chin Tat Lim, David Q K Ng, Ken Jin Tan, Amit K Ramruttun, Wilson Wang, Desmond Y R Chong
BACKGROUND: Autologous bone graft remains the gold standard source of bone graft. Iliac crest has traditionally been the most popular source for autologous bone graft. However, iliac crest bone graft harvesting is associated with high donor site morbidity. Bone graft harvesting from the proximal tibia has shown great potential with reported low complication rates. However, there is a paucity of biomechanical studies concerning the safety as well as yield of proximal bone graft harvesting...
September 13, 2016: Injury
Parvaneh Saffarian, Shahin Najar Peerayeh, Jafar Amani, Firooz Ebrahimi, Hamid Sedighianrad, Raheleh Halabian, Abbas Ali Imani Fooladi
Botulinum toxin type A can temporarily inhibit muscle contraction. Currently, physicians administer this toxin as a bio-drug in treatment of some muscle contraction disorders. TAT-BoNT/A(1-448) is a functional recombinant protein derived from botulinum toxin light chain. Unlike the full length botulinum toxin, TAT-BoNT/A(1-448) is a self-permeable molecule which can pass through bio-surfaces so can be used as a topical therapeutic agent without injection. To maintain the functionality of TAT-BoNT/A(1-448), it is necessary to restore its normal folding upon expression and purification...
August 26, 2016: Bioengineered
Nuran Sungu, Sibel Yavuz, Seda Marali, Serdar Balci, Aydan Kilicarslan, Canan Altunkaya, Hayriye Tatli Dogan, Gülnur Güler
BACKGROUND: We intended to study whether there is a meaningful difference in microscopic examination between dividing a biopsy section into two equal parts before tissue processing (first method) or after (second method). METHODS: A total of 400 cases were included in the study. Punch biopsies (PB) were cut into two pieces using the first method in 200 cases and just before paraffin embedding in another 200 cases using the second method. We microscopically evaluated the epidermal mesh view, the presence of a cross-cut hair follicle and bow shape because of epidermal angling, the presence of two pieces on the slide and if there was a difference of >2 mm between the parts, and the number of new sections and new slides...
August 11, 2016: Journal of Cutaneous Pathology
Christian Matano, Stephan Kolkenbrock, Stefanie N Hamer, Elvira Sgobba, Bruno M Moerschbacher, Volker F Wendisch
BACKGROUND: In Gram-positive Corynebacterium glutamicum and other members of the suborder Corynebacterianeae, which includes mycobacteria, cell elongation and peptidoglycan biosynthesis is mainly due to polar growth. C. glutamicum lacks an uptake system for the peptidoglycan constituent N-acetylglucosamine (GlcNAc), but is able to catabolize GlcNAc-6-phosphate. Due to its importance in white biotechnology and in order to ensure more sustainable processes based on non-food renewables and to reduce feedstock costs, C...
2016: BMC Microbiology
Pan Fu, Maozhong Sun, Liguang Xu, Xiaoling Wu, Liqiang Liu, Hua Kuang, Shanshan Song, Chuanlai Xu
Circular dichroism (CD) has allowed the construction of various chiral nanomaterials for different applications, including biosensing. However, the determination of a simple target-specific, economical, and biocompatible platform using CD with intracellular detection and in situ molecular probing is still required. Here, we show that a DNA zip-fastener structure self-assembled chiral-aptasensor based on gold nanoparticle heterodimers provided an outstanding capability to quantify adenosine-5'-triphosphate (ATP) by addition...
August 11, 2016: Nanoscale
Linda L D Zhong, Wai Kun, Tsz Fung Lam, Shi Ping Zhang, Jun Jun Yang, Tat Chi Ziea, Bacon Ng, Zhao Xiang Bian
BACKGROUND: Obesity is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. Excess body weight is a risk factor contributing to diseases such as hypertension, heart disease, hypercholesterolaemia, diabetes mellitus, cerebrovascular disease, gall bladder disease, and some types of cancer. Almost all the Western anti-obesity drugs have adverse effects or body weight is regained upon cessation of therapy. Recent studies have found that acupuncture had a similar efficacy as the Western anti-obesity drugs with fewer reported adverse effects...
2016: Trials
Yoshitaka Yasuda, Guo-Gang Feng, Jiazheng Li, Emi Nakamura, Hisaki Hayashi, Motohiko Sato, Yoshihiro Fujiwara, Hiroyuki Kinoshita
Whether high oxygen is harmful to the vascular function is unclear. The present study examined if high oxygen modifies vasodilator effect of cysteine via enhanced oxidative stress and thromboxane production. Rat mesenteric arteries with endothelium at 95 or 50 % oxygen were subjected to isometric force recordings, measurement of thromboxane B2 levels, determination of superoxide and peroxynitrite levels and evaluation of NADPH oxidase subunit protein expression, respectively. L-cysteine (0.01-3 mM) constricted or dilated arteries at 95 and 50 % oxygen, respectively...
September 2016: Pflügers Archiv: European Journal of Physiology
Joyce Veld, Elizabeth K O'Donnell, Michaela R Reagan, Andrew J Yee, Martin Torriani, Clifford J Rosen, Miriam A Bredella
OBJECTIVE: To determine abdominal adipose tissue parameters on PET/CT in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) that may serve as predictors of progression of MGUS to MM. We hypothesized that patients with MM had higher abdominal adiposity and higher fat metabolic activity compared to patients with MGUS. MATERIALS AND METHODS: Our retrospective study was IRB approved and HIPAA compliant. The study group comprised 40 patients (mean age 64 ± 13 years) with MGUS and 32 patients (mean age 62 ± 10 years) with recently diagnosed MM (mean time since diagnosis of MM 3...
September 2016: Skeletal Radiology
Chung-Lieh Hung, Chun-Ho Yun, Yau-Huei Lai, Kuo-Tzu Sung, Hiram G Bezerra, Jen-Yuan Kuo, Charles Jia-Yin Hou, Tze-Fan Chao, Bernard E Bulwer, Hung-I Yeh, Shou-Chuan Shih, Shing-Jong Lin, Ricardo C Cury
Excessive visceral adiposity, hypothesized to be a key mediator in metabolic derangements, has recently been shown to exert toxic effects on cardiac structure and function. Data regarding the mechanistic link between regional adiposity, left atrial (LA) electromechanical remodeling, and heart failure with preserved ejection fraction (HFpEF) have been lacking.Various visceral adiposity measures, including pericardial fat (PCF), thoracic periaortic (TAT) fat, regional inter-atrial fat (IAF), and atrioventricular groove fat (AV Groove Fat), were assessed by multidetector computed tomography in 2 study cohorts (an annual health survey cohort and an outpatient cohort)...
June 2016: Medicine (Baltimore)
Dominique Pepe, Vanessa Fm Carvalho, Melissa McCall, Débora P de Lemos, Luciana B Lopes
In this study, the ability of nanocarriers containing protein transduction domains (PTDs) of various classes to improve cutaneous paclitaxel delivery and efficacy in skin tumor models was evaluated. Microemulsions (MEs) were prepared by mixing a surfactant blend (polyoxyethylene 10 oleoyl ether, ethanol and propylene glycol), monocaprylin, and water. The PTD transportan (ME-T), penetratin (ME-P), or TAT (ME-TAT) was added at a concentration of 1 mM to the plain ME. All MEs displayed nanometric size (32.3-40...
2016: International Journal of Nanomedicine
Jimmy Tat, Ioannis N Psaromiligkos, Stella S Daskalopoulou
Longitudinal motion of the artery, a cyclical, bidirectional movement of the wall in the long axis of the artery, has recently gained interest in the characterization of artery function. The aim of this study was to evaluate longitudinal motion in patients with internal carotid atherosclerotic plaques. Speckle tracking ultrasound was used to assess common carotid artery wall motion in 12 patients with carotid plaque causing either moderate (50%-79%) or severe (80%-99%) stenosis based on the North American Carotid Endarterectomy Trial, and 23 healthy participants...
September 2016: Ultrasound in Medicine & Biology
V H Nguyen, V L Nguyen, N S Hoang, T K Do
BACKGROUND: The discovery of proteins with inherent cell membrane-translocating activity will expand our ability to study and manipulate various intracellular processes in living systems. OBJECTIVE: We investigated the effect of TAT-EGFP (trans-activator of transcription-enhanced green fluorescent protein) intra-cellular delivery on the survival and development of mature porcine oocytes after cryopreservasion. MATERIALS AND METHODS: Cumulus-oocyte complexes (COCs) collected from follicles 3 to 6 mm in diameter in abattoir-derived oocytesries of prepubertal gilts were on vitro matured (IVM)...
March 2016: Cryo Letters
Faik Tatli, Ugur Ekici, Murat Kanlioz, Orhan Gozeneli, Ali Uzunkoy, Yusuf Yucel, Abuzer Dirican
PURPOSE: Acute appendicitis is the most common surgical abdominal emergency. In the early diagnosis of acute appendicitis, the fact that there is no a sign which could be a reliable indicator in most of the patients increases the complications. In this study we aimed to search the relation between Ultrasonography(US) findings in patients with diagnosis of acute appendicitis and postoperative histopathologic investigation on remoced appendix.. MATERIALS AND METHODS: The files of 174 patients who came in our emergency department with lower right abdominal pain were studied retrospectively from January 2013 to May 2014...
2016: Annali Italiani di Chirurgia
Soichiro Tani, Servet Tatli, Nobuhiko Hata, Xavier Garcia-Rojas, Olutayo I Olubiyi, Stuart G Silverman, Junichi Tokuda
PURPOSE: Contrast-enhanced MR images are widely used to confirm the adequacy of ablation margin after liver ablation for early prediction of local recurrence. However, quantitative assessment of the ablation margin by comparing pre- and post-procedural images remains challenging. We developed and tested a novel method for three-dimensional quantitative assessment of ablation margin based on non-rigid image registration and 3D distance map. METHODS: Our method was tested with pre- and post-procedural MR images acquired in 21 patients who underwent image-guided percutaneous liver ablation...
June 2016: International Journal of Computer Assisted Radiology and Surgery
Jeffrey M Jacobson, Lu Zheng, Cara C Wilson, Pablo Tebas, Roy M Matining, Michael A Egan, John Eldridge, Alan L Landay, David B Clifford, Anne F Luetkemeyer, Jennifer Tiu, Ana L Martinez, Jennifer Janik, Teresa A Spitz, John Hural, Juliana McElrath, Nicole Frahm
BACKGROUND: Therapeutic vaccination is being studied in eradication and "functional cure" strategies for HIV-1. The Profectus Biosciences multiantigen (MAG) HIV-1 DNA vaccine encodes HIV-1 Gag/Pol, Nef/Tat/Vif, and Envelope, and interleukin-12 (IL-12) and is delivered by electroporation combined with intramuscular injection (IM-EP). METHODS: Sixty-two HIV-1-infected patients on antiretroviral therapy (plasma HIV-1 RNA levels ≤ 200 copies/mL; CD4(+) T-cell counts ≥ 500 cells/mm(3)) were randomly allocated 5:1 to receive vaccine or placebo...
February 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Seyda Gündüz, Sema Sezgin Göksu, Deniz Arslan, Ali Murat Tatli, Mükremin Uysal, Umut Riza Gündüz, Mert Mahsuni Sevinç, Hasan Senol Coşkun, Hakan Bozcuk, Hasan Mutlu, Burhan Savas
Breast cancer is the most frequently diagnosed cancer in women worldwide and the second cause of cancer-related mortality. A total of 20-30% of patients with early-stage breast cancer develop recurrence within the first 5 years following diagnosis. Trastuzumab significantly improves overall survival and disease-free survival (DFS) in women with human epidermal growth factor receptor 2 (HER2)-positive early and locally advanced breast cancer. This study aimed to determine the factors that affect DFS following adjuvant transtuzumab therapy...
September 2015: Molecular and Clinical Oncology
Sjoerd A A van den Berg, Monique J M de Groot, Lorenzo P W Salden, Patrick J G J Draad, Ineke M Dijkstra, Simone Lunshof, Sjoerd W van Thiel, Kristel J M Boonen, Marc H M Thelen
In vitro glycolysis poses a problem during diabetes screening, especially in remote laboratories. Point-of-care analysis (POC) may provide an alternative. We compared POC, routine and STAT analysis and a feasible protocol during glucose tolerance test (GTT) for pregnancy diabetes (GDM) screening. In the routine protocol, heparin tubes were used and turn-around-time (TAT) was unsupervised. In the STAT protocol, tubes were processed immediately. The feasible protocol comprised of citrated tubes with a TAT of 1 hour...
November 6, 2015: Scientific Reports
Benjamin M Howard, Byron Y Miyazawa, Weifeng Dong, Wendy J Cedron, Ryan F Vilardi, Wolfram Ruf, Mitchell Jay Cohen
BACKGROUND: The initiation of coagulation in trauma is thought to originate from exposed tissue factor (TF); recent data have led to the alternative hypothesis that damage-associated molecular patterns may contribute to postinjury coagulation. In acute traumatic coagulopathy, aberrant coagulation is mediated via the activated protein C (aPC) pathway; the upstream regulators of this process and its relation to TF remain uncharacterized. To examine the role of the TF pathway in mediating acute traumatic coagulopathy, we used specific antibody blockades in an established murine model of traumatic hemorrhagic shock, hypothesizing that both coagulation activation after injury and aPC-mediated coagulopathy are driven by TF via thrombin...
December 2015: Journal of Trauma and Acute Care Surgery
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