keyword
https://read.qxmd.com/read/38452866/developing-advanced-patient-specific-in-silico-models-a-new-era-in-biomechanical-analysis-of-tooth-autotransplantation
#1
JOURNAL ARTICLE
Pierre Lahoud, Reinhilde Jacobs, Seyed Ali Elahi, Maxime Ducret, Wout Lauwers, G Harry van Lenthe, Raphaël Richert, Mostafa EzEldeen
INTRODUCTION: As personalized medicine advances, there is an escalating need for sophisticated tools to understand complex biomechanical phenomena in clinical research. Recognizing a significant gap, this study pioneers the development of patient-specific in-silico models for tooth autotransplantation (TAT), setting a new standard for predictive accuracy and reliability in evaluating TAT outcomes. MATERIALS AND METHODS: Development of the models relied on six consecutive cases of young patients (mean age 11...
March 5, 2024: Journal of Endodontics
https://read.qxmd.com/read/38087140/tfp5-a-peptide-derived-from-cdk5-activator-p35-protects-pancreatic-%C3%AE-cells-from-glucose-toxicity
#2
JOURNAL ARTICLE
S-Y Liu, S-L Cao, H-Y Luo, L Bao, J E, B Li, X-M Lan, G-Q Zhang, X Bao, Y-L Zheng
We studied the effect of TFP5 on MIN6 cells (cultured mouse islet β cells) treated with different concentrations of glucose (5 or 25 mM). The results were verified in C57BL/6J mice (control; n=12) and db/db mice with type 2 diabetes mellitus (n=12). To synthesize TFP5, peptide p5 (a derivative of p35 protein, activator of cyclin-dependent kinase 5, Cdk5) was conjugated with a FITC tag at the N-terminus and an 11-amino acid TAT protein transduction domain at the C-terminus. TFP5 was employed to inhibit Cdk5 activity and then to evaluate its efficiency in treating experimental type 2 diabetes mellitus...
December 13, 2023: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38072667/interactive-multi-stage-robotic-positioner-for-intra-operative-mri-guided-stereotactic-neurosurgery
#3
JOURNAL ARTICLE
Zhuoliang He, Jing Dai, Justin Di-Lang Ho, Hon-Sing Tong, Xiaomei Wang, Ge Fang, Liyuan Liang, Chim-Lee Cheung, Ziyan Guo, Hing-Chiu Chang, Iulian Iordachita, Russell H Taylor, Wai-Sang Poon, Danny Tat-Ming Chan, Ka-Wai Kwok
Magnetic resonance imaging (MRI) demonstrates clear advantages over other imaging modalities in neurosurgery with its ability to delineate critical neurovascular structures and cancerous tissue in high-resolution 3D anatomical roadmaps. However, its application has been limited to interventions performed based on static pre/post-operative imaging, where errors accrue from stereotactic frame setup, image registration, and brain shift. To leverage the powerful intra-operative functions of MRI, e.g., instrument tracking, monitoring of physiological changes and tissue temperature in MRI-guided bilateral stereotactic neurosurgery, a multi-stage robotic positioner is proposed...
December 10, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37957034/enhancement-of-adeno-associated-virus-serotype-6-transduction-into-t-cells-with-cell-penetrating-peptides
#4
JOURNAL ARTICLE
Pablo D Moço, Shantoshini Dash, Amine A Kamen
BACKGROUND: Adeno-associated viruses (AAVs) are gaining interest in the development of cellular immunotherapy. Compared to other viral vectors, AAVs can reduce the risk of insertional oncogenesis. AAV serotype 6 (AAV6) shows the highest efficiency for transducing T cells. Nevertheless, a multiplicity of infection (MOI) of up to one million viral genomes per cell is required to transduce the target cells effectively. Cell-penetrating peptides (CPPs) are short, positively charged peptides that easily translocate the plasma membranes and can facilitate the cellular uptake of a wide variety of cargoes, including small molecules, nucleic acids, drugs, proteins and viral vectors...
November 13, 2023: Journal of Gene Medicine
https://read.qxmd.com/read/37774737/the-geometry-of-cold-snare-polypectomy
#5
JOURNAL ARTICLE
Oliver Cronin, David Kirszenblat, Nauzer Forbes, Sunil Gupta, Anthony Whitfield, Timothy O'Sullivan, Julia Gauci, Muhammad Abuarisha, Hunter Wang, Stephen J Williams, Eric Yong Tat Lee, Nicholas Graeme Burgess, Michael J Bourke
Background and Aims Cold snare polypectomy (CSP) is safer and equi-efficacious to hot snare polypectomy (HSP) for the removal of small (<10mm) colorectal polyps. The upper limit of polyp size that can be effectively managed by piecemeal CSP (p-CSP) without an excessive burden of recurrence is unknown. Methods Resection error rate (RER) for CSP and HSP were calculated based on the rate of incomplete resection in the literature. Polyp area, snare size, estimated number of resections and optimal resection defect area were modelled...
September 29, 2023: Endoscopy
https://read.qxmd.com/read/37685768/the-natural-history-and-management-of-hepatic-hemangioma
#6
JOURNAL ARTICLE
Shigeo Maruyama, Tomomitsu Matono, Masahiko Koda
BACKGROUND: Knowledge of the natural history and management of hepatic hemangiomas is lacking. The aim of this study was to investigate the natural history of hemangiomas and to elucidate the factors that determine tumor growth and optimal management. METHODS: A total of 211 adult patients were enrolled, with follow-up for more than three years. Follow-up was performed with repeated ultrasonography (US) and laboratory tests for liver function and coagulation factors (platelets, prothrombin time (PT), fibrinogen, thrombin-antithrombin III complex (TAT), D-dimer, and fibrin and fibrinogen degradation products (FDP))...
September 1, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37502705/evaluating-the-genotoxicity-of-salinity-stress-and-secondary-products-gene-manipulation-in-lime-citrus-aurantifolia-plants
#7
JOURNAL ARTICLE
Hadeer Darwish, Ghaida S Al-Osaimi, Najla Amin T Al Kashgry, Hana Sonbol, Aisha A M Alayafi, Nadiyah M Alabdallah, Abdulrahman Al-Humaid, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Zahid Khorshid Abbas, Doaa Bahaa Eldin Darwish, Mohamed F M Ibrahim, Ahmed Noureldeen
Salinity is a significant abiotic stress that has a profound effect on growth, the content of secondary products, and the genotoxicity of cells. Lime, Citrus aurantifolia , is a popular plant belonging to the family Rutaceae. The interest in cultivating this plant is due to the importance of its volatile oil, which is included in many pharmaceutical industries, but C. aurantifolia plants are affected by the NaCl salinity levels. In the present study, a comet assay test has been applied to evaluate the genotoxic impact of salinity at 0, 50, 100, and 200 mM of NaCl on C...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37209218/sequential-car-t-cell-and-targeted-alpha-immunotherapy-in-disseminated-multiple-myeloma
#8
JOURNAL ARTICLE
Dennis Awuah, Megan Minnix, Enrico Caserta, Theophilus Tandoh, Vikram Adhikarla, Erasmus Poku, Russell Rockne, Flavia Pichiorri, John E Shively, Xiuli Wang
Multiple myeloma (MM) is still an incurable disorder despite improved antibody and cellular therapies against different MM antigens. Single targeted antigens have so far been ineffective against MM with most patients relapsing after initial response. Hence, sequential immunotherapies directed at different targets are expected to perform better than monotherapy alone. Here, we optimized and established in preclinical studies the therapeutic rationale of using targeted alpha therapy (TAT) directed against CD38 antigen (225 Ac-DOTA-daratumumab) with CAR T cell therapy directed at CS1 antigen in a systemic MM model...
May 20, 2023: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/37120310/clinical-and-radiological-outcome-of-osteoscopic-assisted-treatment-of-enchondroma-in-hand-with-artificial-bone-substitute-or-bone-graft-a-7-year-case-series-and-literature-review
#9
JOURNAL ARTICLE
Wai Tat Bernard Yung, Siu Cheong Jeffrey Justin Koo, Chu Kay Michael Mak, Wai Ping Fiona Yu, Wing Lim Tse, Pak Cheong Ho
Background: This study aims to look at the intermediate-term clinical, functional and radiological outcomes of patients with enchondroma in hand treated with osteoscopic-assisted curettage and artificial bone substitute or bone graft. The addition of osteoscopy allows direct visualisation of the bone cavity during and after curettage of tumour tissue without the need of creating a large opening in the bone cortex. This could lead to better clearance of tumour tissue and lower risk of iatrogenic fracture. Methods: A total of 11 patients who received surgery from December 2013 to November 2020 were retrospectively reviewed...
April 2023: Journal of Hand Surgery Asian-Pacific Volume
https://read.qxmd.com/read/37111490/development-of-a-high-throughput-urosepsis-mouse-model
#10
JOURNAL ARTICLE
Roman Herout, Sreeparna Vappala, Sarah Hanstock, Igor Moskalev, Ben H Chew, Jayachandran N Kizhakkedathu, Dirk Lange
Murine sepsis models are typically polymicrobial, and are associated with high mortality. We aimed to develop a high-throughput murine model that mimics a slow-paced, monomicrobial sepsis originating from the urinary tract. A total of 23 male C57Bl/6 mice underwent percutaneous insertion of a 4 mm catheter into the bladder using an ultrasound-guided method, previously developed by our group. The following day, Proteus mirabilis (PM) was introduced percutaneously in the bladder in three groups: g1-50 µL 1 × 108 CFU/mL solution ( n = 10); g2-50 µL 1 × 107 CFU/mL solution ( n = 10); and g3 (sham mice)-50 µL sterile saline ( n = 3)...
April 15, 2023: Pathogens
https://read.qxmd.com/read/36902994/deep-learning-based-acoustic-metamaterial-design-for-attenuating-structure-borne-noise-in-auditory-frequency-bands
#11
JOURNAL ARTICLE
Ting-Wei Liu, Chun-Tat Chan, Rih-Teng Wu
In engineering acoustics, the propagation of elastic flexural waves in plate and shell structures is a common transmission path of vibrations and structure-borne noises. Phononic metamaterials with a frequency band gap can effectively block elastic waves in certain frequency ranges, but often require a tedious trial-and-error design process. In recent years, deep neural networks (DNNs) have shown competence in solving various inverse problems. This study proposes a deep-learning-based workflow for phononic plate metamaterial design...
February 24, 2023: Materials
https://read.qxmd.com/read/36710047/clonogenic-assay-to-measure-bystander-cytotoxicity-of-targeted-alpha-particle-therapy
#12
JOURNAL ARTICLE
Julie Constanzo, Clara Diaz Garcia-Prada, Jean-Pierre Pouget
Radiation therapy induces targeted effects in the cells that are irradiated and also non-targeted effects (i.e. bystander effects) in non-irradiated cells that are close to or at short distance (<∼1 mm) from irradiated cells. Bystander effects are mediated by intercellular communications and may result in cytotoxic and genotoxic modifications. Their occurrence and relative contribution to the irradiation outcome are influenced by several parameters among which the particle linear energy transfer seems to be prominent...
2023: Methods in Cell Biology
https://read.qxmd.com/read/36385944/enhanced-recruitment-of-glutamate-receptors-underlies-excitotoxicity-of-mitral-cells-in-acute-hyperammonemia
#13
JOURNAL ARTICLE
Mingxian Li, Zhenqi Liu, Ke Lai, Hanwei Liu, Lina Gong, Haosong Shi, Weitian Zhang, Hui Wang, Haibo Shi
Hepatic encephalopathy (HE)-a major complication of liver disease-has been found to increase the risk of olfactory dysfunction, which may be attributed to elevated levels of ammonia/ammonium in the blood and cerebrospinal fluid. However, the cellular mechanisms underlying hyperammonemia-induced olfactory dysfunction remain unclear. By performing patch-clamp recordings of mitral cells (MCs) in the mouse olfactory bulb (OB), we found that 3 mM ammonium (NH4 + ) increased the spontaneous firing frequency and attenuated the amplitude, but synaptic blockers could prevent the changes, suggesting the important role of glutamate receptors in NH4 + -induced hyperexcitability of MCs...
2022: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/36302508/one-pot-biosynthesis-of-l-aspartate-from-maleic-anhydride-via-a-thermostable-dual-enzyme-system-under-high-temperature
#14
JOURNAL ARTICLE
Hongming Liu, Xuan Zong, Yuanxiu Wang, Xiaye Yin, Mengna Liu, Shiyan Liu, Guoping Zhu, Shangping Fang
l-Aspartate is an important chemical in the food and pharmaceutical industries. Herein, a dual-enzyme system was constructed to synthesize l-aspartate from maleic anhydride at 50 °C, which can reduce the byproduct production. Maleate transformed from maleic anhydride in the solution was converted into l-aspartate via fumarate catalyzed by maleate isomerase (MaiA) and thermostable aspartase (AspB), respectively. Because MaiA is a rate-limiting enzyme, enzyme activities of various MaiAs were compared, and the efficient and thermostable maleate isomerase Aa MaiA from Alicyclobacillus acidoterrestris was chosen...
October 27, 2022: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/36223000/does-conduction-heterogeneity-determine-the-supervulnerable-period-after-atrial-fibrillation
#15
JOURNAL ARTICLE
Annejet Heida, Willemijn F B van der Does, Mathijs S van Schie, Lianne N van Staveren, Yannick J H J Taverne, Ad J J C Bogers, Natasja M S de Groot
Atrial fibrillation (AF) resumes within 90 s in 27% of patients after sinus rhythm (SR) restoration. The aim of this study is to compare conduction heterogeneity during the supervulnerable period immediately after electrical cardioversion (ECV) with long-term SR in patients with AF. Epicardial mapping of both atria was performed during SR and premature atrial extrasystoles in patients in the ECV (N = 17, age: 73 ± 7 years) and control group (N = 17, age: 71 ± 6 years). Inter-electrode conduction times were used to identify areas of conduction delay (CD) (conduction times 7-11 ms) and conduction block (CB) (conduction times ≥ 12 ms)...
October 12, 2022: Medical & Biological Engineering & Computing
https://read.qxmd.com/read/36208666/associations-of-secretory-activation-breastmilk-biomarkers-with-breastfeeding-outcome-measures
#16
JOURNAL ARTICLE
Anita L Esquerra-Zwiers, Carly Mulder, Lauren Czmer, Anastasia Perecki, Emilie Dykstra Goris, Ching Tat Lai, Donna Geddes
OBJECTIVE(S): To explore associations between day 10 postpartum (D10) secretory activation biomarkers with the breastfeeding outcome measures. STUDY DESIGN: This prospective longitudinal descriptive study collected antepartum, D10 and day 60 postpartum (D60) questionnaire data, and D10 milk samples. Protein, lactose, and citrate were analyzed with enzymatic spectrophotometric assays. Sodium and potassium were analyzed with inductively coupled plasma optical emission spectrophotometry...
October 5, 2022: Journal of Pediatrics
https://read.qxmd.com/read/36143576/microstructural-characteristics-and-hardness-enhancement-of-super-duplex-stainless-steel-by-friction-stir-processing
#17
JOURNAL ARTICLE
Linlin Pan, Chi Tat Kwok, Kin Ho Lo
In the present study, microstructural evolution and hardness of the friction stir processed (FSPed) SAF 2507 super duplex stainless steel fabricated at a rotational speed of 650 rpm and a traverse speed of 60 mm/min were investigated. A scanning electron microscope (SEM) equipped with an electron backscatter diffraction (EBSD) detector was used to study the microstructure of the stir zone. The grain sizes of austenite and ferrite in the FSPed 2507 were found to be smaller (0.75 and 0.96 μm) than those of the substrate (6...
September 9, 2022: Materials
https://read.qxmd.com/read/36094609/the-thoracoacromial-trunk-a-detailed-analysis
#18
JOURNAL ARTICLE
Michał Bonczar, Kamil Gabryszuk, Patryk Ostrowski, Jakub Batko, Daniel Jakub Rams, Agata Krawczyk-Ożóg, Wadim Wojciechowski, Jerzy Walocha, Mateusz Koziej
PURPOSE: The thoracoacromial trunk (TAT) originates from the second part of the axillary artery and curls around the superomedial border of the pectoralis minor, subsequently piercing the costocoracoid membrane. Knowledge about the location, morphology, and variations of the TAT and its branches is of great surgical importance due to its frequent use in various reconstructive flaps. METHODS: A retrospective study was conducted to establish anatomical variations, their prevalence, and morphometric data on TAT and its branches...
September 12, 2022: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/35924260/tat-rgd-peptide-modified-naringin-loaded-lipid-nanoparticles-promote-the-osteogenic-differentiation-of-human-dental-pulp-stem-cells
#19
JOURNAL ARTICLE
Chun-Yan Zheng, Xiao-Yang Chu, Chun-Yan Gao, Hua-Ying Hu, Xin He, Xu Chen, Kai Yang, Dong-Liang Zhang
Background: Naringin is a naturally occurring flavanone that promotes osteogenesis. Owing to the high lipophilicity, poor in vivo bioavailability, and extensive metabolic alteration upon administration, the clinical efficacy of naringin is understudied. Additionally, information on the molecular mechanism by which it promotes osteogenesis is limited. Methods: In this study, we prepared TAT & RGD peptide-modified naringin-loaded nanoparticles (TAT-RGD-NAR-NPs), evaluated their potency on the osteogenic differentiation of human dental pulp stem cells (hDPSCs), and studied its mechanism of action through metabolomic analysis...
2022: International Journal of Nanomedicine
https://read.qxmd.com/read/35881112/developing-high-affinity-decoy-receptors-to-treat-multiple-myeloma-and-diffuse-large-b-cell-lymphoma
#20
JOURNAL ARTICLE
Yu Rebecca Miao, Kaushik Thakkar, Can Cenik, Dadi Jiang, Kazue Mizuno, Chenjun Jia, Caiyun Grace Li, Hongjuan Zhao, Anh Diep, Yu Xu, Xin Eric Zhang, Teddy Tat Chi Yang, Michaela Liedtke, Parveen Abidi, Wing-Sze Leung, Albert C Koong, Amato J Giaccia
Disease relapse and treatment-induced immunotoxicity pose significant clinical challenges for patients with hematological cancers. Here, we reveal distinctive requirements for neutralizing TNF receptor ligands APRIL and BAFF and their receptor activity in MM and DLBCL, impacting protein translation and production in MM cells and modulating the translation efficiency of the ATM interactor (ATMIN/ACSIZ). Therapeutically, we investigated the use of BCMA decoy receptor (sBCMA-Fc) as an inhibitor of APRIL and BAFF...
September 5, 2022: Journal of Experimental Medicine
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