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https://www.readbyqxmd.com/read/29118299/the-effect-of-cilostazol-on-the-angiographic-outcome-of-drug-eluting-coronary-stents-angiographic-analysis-of-the-cilon-t-influence-of-cilostazol-based-triple-antiplatelet-therapy-on-ischemi-complication-after-drug-eluting-stent-implantation-trial
#1
Jung-Won Suh, Seung-Pyo Lee, KyungWoo Park, Hyun-Jae Kang, Bon-Kwon Koo, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Seung-Woon Rha, Jang-Ho Bae, Taek-Geun Kwon, Jang-Whan Bae, Myeong-Chan Cho, Hyo-Soo Kim
It is not clear if anti-restonotic effect of cilostazol is consistent for different types of drug-eluting stents (DES).The purpose of this study was to compare the anti-proliferative effect of cilostazol between DAT and TAT with consideration of confounding influences of DES type.Nine hundred and fifteen patients were randomized to either dual antiplatelet therapy (DAT; aspirin and clopidogrel) or triple antiplatelet therapy (TAT; aspirin, clopidogrel, and cilostazol) in the previous CILON-T trial. After excluding 70 patients who received both or neither stents, we analyzed 845 patients who received exclusively PES or ZES, and compared in-stent late loss at 6 months between both antiplatelet regimens (DAT versus TAT)...
November 8, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29115910/factors-associated-with-long-turnaround-time-for-early-infant-diagnosis-of-hiv-in-myanmar
#2
Soe Thiha, Hemant Deepak Shewade, Sairu Philip, Thet Ko Aung, Nang Thu Thu Kyaw, Myo Minn Oo, Khine Wut Yee Kyaw, May Wint War, Htun Nyunt Oo
BACKGROUND: A previous review of early infant diagnosis (EID) using polymerase chain reaction technology (PCR) under integrated HIV care (IHC) program in Myanmar revealed a low uptake of timely (within 6 to 8 weeks of babies' age) EID and a long turnaround time (TAT) of receiving results. OBJECTIVE: This study aimed to determine the proportion and factors associated with the composite outcome of a long TAT (≥7 weeks; from sample collection to receipt of result by mother) or nonreceipt of result among HIV-exposed babies whose blood samples were collected for PCR at <9 months of age under the IHC program, Myanmar (2013-15)...
2017: Global Health Action
https://www.readbyqxmd.com/read/29025679/relation-of-residual-mitral-regurgitation-despite-elevated-mitral-gradients-to-risk-of-heart-failure-hospitalization-after-mitraclip-repair
#3
Richard Cheng, Sam Dawkins, Emily Tat, Moody Makar, Asma Hussaini, Raj R Makkar, Alfredo Trento, Robert J Siegel, Saibal Kar
Achieving minimal residual mitral regurgitation (MR) after percutaneous MitraClip repair is limited by iatrogenic mitral stenosis. It is unknown whether allowing moderately elevated postprocedural mean mitral gradients (MMGs) to achieve < moderate residual MR is preferable to moderate residual regurgitation. Patients with less-than-moderate residual MR but a MMG of ≥5 mm Hg (Group 1) were compared with patients with moderate residual MR (Group 2). The primary end point was heart failure hospitalization...
November 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28844037/targeting-the-anterior-superior-iliac-spine-yields-significantly-longer-bone-marrow-cores
#4
Louis Reed, Shirin Attarian, Gopichand Pendurti, Aditi P Singh, Anjali Budhathoki, Simon Abi-Aad, Urvi A Shah, Salem Kim, Kimo Bachiashvili, Jee Young Moon, Mimi Kim, Tarek Elrafei, Karenza Alexis, Marianna Strakhan, Weijuan Li, Ellen Friedman
Pathologists and haematologists generally agree that the length of the biopsy core is a good surrogate for the diagnostic quality of the bone marrow. Previous studies suggested that the angulation of the biopsy needle from the posterior superior iliac spine (PSIS) could influence the length of the biopsy cores, targeting the anterior superior iliac spine (ASIS) from the PSIS would yield longer specimens than the traditional angulation technique (TAT), where the biopsy needle is directed straight in, perpendicular to the plane of the back...
August 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28832072/can-cutting-needle-biopsy-be-an-alternative-to-excisional-biopsy-in-lymph-node-pathologies
#5
Aydan Kiliçarslan, Mehmet Doğan, Nuran Süngü, Emre Karakök, Leman Karabekmez, Mesut Akyol, Hayriye Tatli Doğan
OBJECTIVE: We aimed to compare cutting-needle biopsy (CNB) diagnoses with excisional biopsy diagnoses of enlarging lymph nodes and to determine the diagnostic value of CNB. MATERIAL AND METHOD: Out of the 291 cases that underwent CNB from lymph nodes between 2010 and 2016, 60 were included in the study in which pathological lymph nodes were excised after CNB. Demographic information, pathology and imaging reports, the diameters of the lymph nodes and the length of the CNBs of these cases were obtained from the hospital registry system...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28687763/a-tyrosine-aminotransferase-involved-in-rosmarinic-acid-biosynthesis-in-prunella-vulgaris-l
#6
Mei Ru, Kunru Wang, Zhenqing Bai, Liang Peng, Shaoxuan He, Yong Wang, Zongsuo Liang
Rosmarinic acid (RA) and its derivants are medicinal compounds that comprise the active components of several therapeutics. We isolated and characterised a tyrosine aminotransferase of Prunella vulgaris (PvTAT). Deduced PvTAT was markedly homologous to other known/putative plant TATs. Cytoplasmic localisation of PvTAT was observed in tobacco protoplasts. Recombinantly expressed and purified PvTAT had substrates preference for L-tyrosine and phenylpyruvate, with apparent K m of 0.40 and 0.48 mM, and favoured the conversion of tyrosine to 4-hydroxyphenylpyruvate...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28593463/factors-which-modulate-the-rates-of-skeletal-muscle-mass-loss-in-non-small-cell-lung-cancer-patients-a-pilot-study
#7
Philippe Atlan, Mohamed Amine Bayar, Emilie Lanoy, Benjamin Besse, David Planchard, Jordy Ramon, Bruno Raynard, Sami Antoun
PURPOSE: Advanced non-small cell lung cancer (NSCLC) is associated with weight loss which may reflect skeletal muscle mass (SMM) and/or total adipose tissue (TAT) depletion. This study aimed to describe changes in body composition (BC) parameters and to identify the factors unrelated to the tumor which modulate them. METHODS: SMM, TAT, and the proportion of SMM to SMM + TAT were assessed with computed tomography. Estimates of each BC parameter at follow-up initiation and across time were derived from a mixed linear model of repeated measurements with a random intercept and a random slope...
November 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28574351/fabrication-and-characterization-of-a-20-mhz-microlinear-phased-array-transducer-for-intervention-guidance
#8
Chi Tat Chiu, Bong Jin Kang, Payam Eliahoo, Theodore Abraham, K Kirk Shung
This paper describes the design and fabrication of a miniature ultrasonic phased-array transducer used for intervention guidance. Currently, ultrasound probes are often placed at the body surface of the patients, leading to several drawbacks including the limitation of penetration and image quality. In order to improve the reliability of the guiding process, we propose a miniature phased-array transducer that can be placed adjacent to the intervention device during the interventional procedure. In this paper, we report the work that has been carried out on the development of this miniature phased-array transducer...
August 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28465260/is-ultrasonographically-detected-nodule-diameter-concordant-with-pathological-tumor-size
#9
Muhammet Cuneyt Bilginer, Didem Ozdemir, Husniye Baser, Hayriye Tatli Dogan, Abdussamed Yalcin, Reyhan Ersoy, Bekir Cakir
INTRODUCTION: We aimed to compare preoperative ultrasonographical and postoperative histopathological diameters of differentiated thyroid cancer (DTC) lesions and investigate possible factors that can predict the discordance between two measurements. METHODS: Data of patients with histopathologically confirmed DTC were reviewed retrospectively. Nodules evaluated by preoperative US were matched with histopathologically examined nodules. Incidental tumors and nodules that can not be matched in US and histopathology reports were excluded...
June 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28272688/can-cutting-needle-biopsy-be-an-alternative-to-excisional-biopsy-in-lymph-node-pathologies
#10
Aydan Kiliçarslan, Mehmet Doğan, Nuran Süngü, Emre Karakök, Leman Karabekmez, Mesut Akyol, Hayriye Tatli Doğan
OBJECTIVE: We aimed to compare cutting-needle biopsy (CNB) diagnoses with excisional biopsy diagnoses of enlarging lymph nodes and to determine the diagnostic value of CNB. MATERIAL AND METHOD: Out of the 291 cases that underwent CNB from lymph nodes between 2010 and 2016, 60 were included in the study in which pathological lymph nodes were excised after CNB. Demographic information, pathology and imaging reports, the diameters of the lymph nodes and the length of the CNBs of these cases were obtained from the hospital registry system...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28154562/indian-long-term-non-progressors-show-broad-adcc-responses-with-preferential-recognition-of-v3-region-of-envelope-and-a-region-from-tat-protein
#11
Archana Kulkarni, Swarali Kurle, Ashwini Shete, Manisha Ghate, Sheela Godbole, Vijaya Madhavi, Stephen J Kent, Ramesh Paranjape, Madhuri Thakar
HIV-specific antibody-dependent cell cytotoxicity (ADCC) is likely to be important in governing protection from human immunodeficiency virus (HIV) and slowing disease progression. Little is known about the ADCC responses to HIV-1 subtype C. We characterized ADCC responses in HIV-1 subtype C-infected Indian subjects with slow disease progression and identified the dominant antigenic regions recognized by these antibodies. ADCC responses were measured in plasma from 34 long-term non-progressors (LTNPs), who were asymptomatic and maintained CD4 count above 500 cells/mm(3) for the last 7 years in the absence of antiretroviral therapy (ART), and 58 ART naïve progressors with CD4 count <500 cells/mm(3) against overlapping HIV-1 peptides using a flow cytometry-based antibody-dependent natural killer (NK) cell activation assay...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28144149/can-achilles-tendon-be-used-as-a-new-distal-landmark-for-coronal-tibial-component-alignment-in-total-knee-replacement-surgery-an-observational-mri-study
#12
Uğur Tiftikçi, Sancar Serbest, Veysel Burulday
BACKGROUND: In total knee arthroplasty, it is better to use more than one reference point for correct alignment of the components. By measuring the distances of Achilles tendon (AT) and other conventional landmarks from the mechanical axis in magnetic resonance imaging (MRI) of the ankle, we aimed to demonstrate that, as a novel landmark which can help for correct alignment in the coronal plane, AT is a better option than other landmarks. MATERIALS AND METHODS: This retrospective study was done on 53 ankle MRIs that met the criteria for inclusion to the study among 158 ankle MRIs...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28130016/cortical-strut-allograft-support-of-modular-femoral-junctions-during-revision-total-hip-arthroplasty
#13
Chin Tat Lim, Derek F Amanatullah, James I Huddleston, Katherine L Hwang, William J Maloney, Stuart B Goodman
BACKGROUND: There is risk of junction failure when using modular femoral stems for revision total hip arthroplasty (THA), especially with loss of bone stock in the proximal femur. Using a cortical strut allograft may provide additional support of a modular femoral construct in revision THA. METHODS: We reviewed prospectively gathered clinical and radiographic data for 28 revision THAs performed from 2004 to 2014 using cementless modular femoral components with cortical strut allograft applied to supplement proximal femoral bone loss: 5 (18%) were fluted taper designs and 23 (82%) were porous cylindrical designs All the patients had a Paprosky grade IIIA or greater femoral defect...
May 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28128891/nuclear-targeted-multifunctional-magnetic-nanoparticles-for-photothermal-therapy
#14
Haibao Peng, Jing Tang, Rui Zheng, Guannan Guo, Angang Dong, Yajun Wang, Wuli Yang
The pursuit of multifunctional, innovative, more efficient, and safer cancer treatment has gained increasing interest in the research of preclinical nanoparticle-mediated photothermal therapy (PTT). Cell nucleus is recognized as the ideal target for cancer treatment because it plays a central role in genetic information and the transcription machinery reside. In this work, an efficient nuclear-targeted PTT strategy is proposed using transferrin and TAT peptide (TAT: YGRKKRRQRRR) conjugated monodisperse magnetic nanoparticles, which can be readily functionalized and stabilized for potential diagnostic and therapeutic applications...
January 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28119014/a-retrospective-analysis-of-nebulized-versus-intravenous-fentanyl-for-renal-colic
#15
COMPARATIVE STUDY
Melih Imamoglu, Ali Aygun, Omer Bekar, Erkan Erdem, Mustafa Cicek, Ozgur Tatli, Yunus Karaca, Aynur Sahin, Suha Turkmen, Suleyman Turedi
STUDY OBJECTIVE: To assess the effectiveness of nebulized fentanyl used for analgesia in renal colic. MATERIALS/METHODS: This research was planned as a randomized, blinded study in which prospectively collected data were analyzed retrospectively to compare nebulized and intravenous (iv) fentanyl therapies. Patients with renal colic with 'moderate' or worse pain on a four-point verbal pain score (VPS) or with pain of 20mm or above on a 100-mm visual analogue score (VAS) at time of presentation were randomized into iv fentanyl (n=62) or nebulized fentanyl (n=53) study groups...
May 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28030717/pathologic-evaluation-of-skin-tumors-with-ex-vivo-dermoscopy-with-derm-dotting
#16
Marc Haspeslagh, Isabelle Hoorens, Nele Degryse, Ine De Wispelaere, Annemarie Degroote, Sarah Van Belle, Jan Verboven, Katrien Vossaert, Fabio Facchetti, Jo Van Dorpe, Sofie De Schepper, Lieve Brochez
Importance: Ex vivo dermoscopy (EVD) with derm dotting (DD) improves clinicopathologic correlation and the quality of diagnosis in skin tumors. Objective: To compare the diagnostic performance of the standard method of skin biopsy processing with the practice of EVD with DD. Design, Setting, and Participants: This retrospective study compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a standard method of processing with 8584 biopsy specimens examined in 2015 with EVD and DD...
December 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27923596/revision-hip-arthroplasty-using-a-modular-cementless-femoral-stem-intermediate-term-follow-up
#17
Sureshan Sivananthan, Chin-Tat Lim, Rapeepat Narkbunnam, Alex Sox-Harris, James I Huddleston, Stuart B Goodman
BACKGROUND: Modular femoral stem provides flexibility in femoral reconstruction, ensuring improved "fit and fill". However, there are risks of junction failure and corrosion, as well as cost concerns in the use of modular femoral stems. METHODS: We reviewed prospectively-gathered clinical and radiographic data on revision total hip arthroplasties (THAs) performed from 2001-2007 using modular, cementless femoral component performed by the 2 senior authors. Patients with a minimum follow-up of 7 years were included in this study...
April 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27889091/breath-hold-pet-ct-guided-tumour-ablation-under-general-anaesthesia-accuracy-of-tumour-image-registration-and-projected-ablation-zone-overlap
#18
P B Shyn, S Tremblay-Paquet, K Palmer, S Tatli, K Tuncali, O I Olubiyi, N Hata, S G Silverman
AIM: To assess single-breath-hold combined positron-emission tomography/computed tomography (PET/CT) for accuracy of tumour image registration and projected ablation volume overlap in patients undergoing percutaneous PET/CT-guided tumour-ablation procedures under general anaesthesia. MATERIALS AND METHODS: Eight patients underwent 12 PET/CT-guided tumour-ablation procedures to treat 20 tumours in the lung, liver, or adrenal gland. Using breath-hold PET/CT, the centre of the tumour was marked on each PET and CT acquisition by four readers to assess two- (2D) and three-dimensional (3D) spatial misregistration...
March 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27753604/mitral-annular-calcification-is-not-associated-with-decreased-procedural-success-durability-of-repair-or-left-ventricular-remodelling-in-percutaneous-edge-to-edge-repair-of-mitral-regurgitation
#19
Richard Cheng, Emily Tat, Robert J Siegel, Reza Arsanjani, Asma Hussaini, Moody Makar, Yukiko Mizutani, Alfredo Trento, Saibal Kar
AIMS: Mitral annular calcification (MAC) negatively influences outcomes in surgical mitral valve (MV) repair for mitral regurgitation (MR). However, there are no data on whether MAC impacts on outcomes of MitraClip percutaneous MV edge-to-edge repair. This study sought to investigate whether the presence of MAC impacts on the procedural success and durability of percutaneous transcatheter repair of MR using the MitraClip. METHODS AND RESULTS: One hundred and seventy-three patients undergoing MitraClip repair for significant MR were studied...
October 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27679933/controlled-banked-turns-in-coleopteran-flight-measured-by-a-miniature-wireless-inertial-measurement-unit
#20
Yao Li, Feng Cao, Tat Thang Vo Doan, Hirotaka Sato
The mechanisms and principles of insect flight have long been investigated by researchers working on micro and nano air vehicles (MAVs/NAVs). However, studies of insect flight maneuvers require high speed filming and high spatial resolution in a small experimental space, or the tethering of the insect to a fixed place. Under such artificial conditions, the insects may deviate its flying behavior from that of regular flight. In this study, we mounted a tiny wireless system, or 'backpack', on live beetles (Mecynorrhina torquata; length 62 ± 8 mm; mass 7...
2016: Bioinspiration & Biomimetics
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