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Artery stiffness

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https://www.readbyqxmd.com/read/29148291/effectiveness-and-safety-of-anti-ischemic-trimetazidine-in-patients-with-stable-angina-pectoris-and-type-2-diabetes
#1
Zsófia Meiszterics, Attila Kónyi, Gábor Hild, Zsolt Sárszegi, Balázs Gaszner
Aim & methods: This 6-month prospective, observational, noninterventional, open-label clinical study assessed the effectiveness/safety of trimetazidine in 737 patients with stable angina pectoris and Type 2 diabetes mellitus (OGYI/51534-1/2014). RESULTS: Trimetazidine-based therapy was effective in stable coronary artery disease, with significant improvements from baseline (p < 0.05) in: number of angina attacks/week (2.9 ± 2.4 vs 1.1 ± 1.6), angina severity (Canadian Cardiovascular Society Classification 1...
November 17, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29147168/study-of-the-characteristics-of-pulmonary-trunk-in-pulmonary-hypertension-secondary-to-left-heart-disease-using-pressure-velocity-loops-pu-loops
#2
Shizuo Hanya, Kengo Yoshii, Motoaki Sugawara
Objectives: Although pulmonary hypertension (PH) caused by left heart disease (PH-LHD) is more common in PH, little is known about its properties of pulmonary artery (PA) in PH-LHD. The purpose of this study was to measure pulmonary regional pulse wave velocity (PWV) and to quantify the magnitude of reflected waves in patients with PH-LHD by the analysis of the pressure-velocity loops (PU-loop). Methods: High-fidelity PA pressure (Pm) and PA velocity (Vm) were measured in 11 subjects with PH-LHD (mean Pm>25 mmHg), 1 subject with atrial septal defect (ASD) without PH and 12 control subjects, using multisensor catheters...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29147132/numerical-investigation-of-pulse-wave-propagation-in-arteries-using-fluid-structure-interaction-capabilities
#3
Hisham Elkenani, Essam Al-Bahkali, Mhamed Souli
The aim of this study is to present a reliable computational scheme to serve in pulse wave velocity (PWV) assessment in large arteries. Clinicians considered it as an indication of human blood vessels' stiffness. The simulation of PWV was conducted using a 3D elastic tube representing an artery. The constitutive material model specific for vascular applications was applied to the tube material. The fluid was defined with an equation of state representing the blood material. The onset of a velocity pulse was applied at the tube inlet to produce wave propagation...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29145340/open-repair-of-intraoperative-popliteal-artery-injury-during-total-knee-arthroplasty-in-a-patient-with-severe-hemophilia-a-a-case-report-and-literature-review
#4
Bin Feng, Ke Xiao, Jiang Shao, Yu Fan, Xisheng Weng
RATIONALE: Arterial injuries during total knee arthroplasty (TKA) though rare may occur. Hemophilia may further challenge the management of such injury. PATIENT CONCERNS: A 48-year-old male patient with severe hemophilia type A and stiff knee arthropathy underwent bilateral TKAs. Left popliteal artery injury was detected at the end of the left TKA. DIAGNOSES: Urgent angiography confirmed the diagnosis of the left popliteal artery transection...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145217/association-of-female-sex-and-heart-rate-with-increased-arterial-stiffness-in-patients-with-type-2-diabetes-mellitus
#5
Min Kyung Kang, Jae Myung Yu, Kwang Jin Chun, Jaehuk Choi, Seonghoon Choi, Namho Lee, Jung Rae Cho
OBJECTIVE: This study aimed to evaluate the factors associated with increased arterial stiffness (IAS) measured by pulse wave velocity (PWV) and its clinical implications in patients with type 2 diabetes mellitus (DM). METHODS: This was an observational, cross-sectional study. The ankle-brachial PWV was used to measure arterial stiffness, and 310 patients (mean age, 49±9 years; 180 men) with type 2 DM were divided into two groups according to the results of PWV: Group 1 (IAS; n=214) and Group 2 (normal arterial stiffness; n=96)...
November 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29143384/enhanced-ventricular-arterial-coupling-during-a-2-year-physical-activity-program-in-patients-with-rheumatoid-arthritis
#6
Philip Sarajlic, Cecilia Fridén, Lars H Lund, Aristomenis Manouras, Ashwin Venkateshvaran, Susanna C Larsson, Birgitta Nordgren, Christina H Opava, Ingrid E Lundberg, Magnus Bäck
OBJECTIVE: To establish how guided physical activity in patients with rheumatoid arthritis (RA) without known cardiovascular disease affected vascular and cardiac function, and how these two entities were prospectively interconnected in this patient group. METHODS: Prospective substudy of 29 participants in the Physical Activity in RA (PARA) 2010 trial. All subjects were examined at baseline, at year 1 and 2 with measures of pulse wave velocity and arterial augmentation index, as well as echocardiographic evaluation of diastolic parameters and ventricular-arterial coupling...
November 15, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29142811/carotid-artery-stiffness-and-development-of-hypertension-in-people-with-paraplegia-and-no-overt-cardiovascular-disease-a-7-year-follow-up-study
#7
Olga Vriz, Nicole Bertin, Arianna Ius, Emiliana Bizzarini, Eduardo Bossone, Francesco Antonini-Canterin
Objectives: The aim of this study was to compare arterial stiffness between people with paraplegia and able-bodied persons (ABPs) and to assess cardiovascular markers that may be predictive of the development of arterial hypertension in people with spinal cord injury (SCI). Setting: This study was conducted at rehabilitation Hospital, Udine (Italy). Methods: Fifty-seven patients with SCI were prospectively enrolled and compared with 88 healthy ABPs...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29142490/postoperative-elevated-resistive-indices-do-not-predict-hepatic-artery-thrombosis-in-extended-criteria-donor-livers
#8
Eric J Siskind, Fauzia Vandermeer, Tamar R Siskind, David A Bruno, Samuel Sultan, Josue Alvarez-Casas, Arielle Stafford, Barton Lane, John C Lamattina, Rolf N Barth, Steven I Hanish
Postoperative transplant liver ultrasounds were analyzed in standard criteria donor (SCD), extended criteria donor (ECD), and donation after cardiac death (DCD) liver allografts to determine if elevated resistive indices (RIs) are consistently present and if they are pathological. Postoperative transplant liver ultrasounds were reviewed from 115 consecutive patients. Hepatic arterial RIs were stratified based on the type of donor: DCD, macrosteatosis (>30%), or standard criteria. In all patients with elevated RI, subsequent ultrasounds were reviewed to demonstrate RI normalization...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29131886/determinant-factors-for-arterial-hemodynamics-in-hypertension-theoretical-insights-from-a-computational-model-based-study
#9
Fuyou Liang, Debao Guan, Jordi Alastruey
Hypertension is a well-documented predictive factor for cardiovascular events. Clinical studies have extensively demonstrated the differential hemodynamic consequences of various anti-hypertensive drugs, but failed to clearly elucidate the underlying mechanisms due to the difficulty in performing a quantitative deterministic analysis based on clinical data that carry confounding information stemming from inter-patient differences and the nonlinearity of cardiovascular hemodynamics. In the present study, a multi-scale model of the cardiovascular system was developed to quantitatively investigate the relationships between hemodynamic variables and cardiovascular properties under hypertensive conditions, aiming to establish a theoretical basis for assisting in the interpretation of clinical observations or optimization of therapy...
November 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29129735/arterial-stiffness-and-cerebral-hemodynamic-pulsatility-during-cognitive-engagement-in-younger-and-older-adults
#10
Kevin S Heffernan, Jacqueline A Augustine, Wesley K Lefferts, Nicole L Spartano, William E Hughes, Randall S Jorgensen, Brooks B Gump
This study examined central artery stiffness and hemodynamic pulsatility during cognitive engagement in younger and older adults. METHODS: Vascular-hemodynamic measures were completed in 19 younger (age 35±1yrs) and 20 older (age 69±2yrs) adults at rest and during a Stroop task. Aortic stiffness (carotid-femoral pulse wave velocity, PWV) and carotid pulse pressure (PP) were assessed using applanation tonometry. Carotid stiffness was assessed as a single-point PWV using Doppler Ultrasound...
November 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29126178/the-impact-of-intradialytic-pedaling-exercise-on-arterial-stiffness-a-pilot-randomized-controlled-trial-in-a-hemodialysis-population
#11
Alexandra B Cooke, Vincent Ta, Sameena Iqbal, Yessica-Haydee Gomez, Thomas Mavrakanas, Paul Barré, Murray Vasilevsky, Elham Rahme, Stella S Daskalopoulou
Objectives: Regular exercise is known to reduce arterial stiffness (AS) in hemodialysis patients. However, the impact of a more realistic intradialytic form of exercise, such as pedaling, is unclear. We aimed to examine 1) the effect of intradialytic pedaling exercise on AS over 4 months, and 2) the longer-term effect of pedaling on AS 4 months after exercise cessation. Methods: Patients on stable in-center hemodialysis (3x/week) were randomly assigned 1:1 to either intradialytic pedaling exercise (EX) or to a control group receiving usual hemodialysis (nonEX) for 4 months...
November 6, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29122942/a-special-report-on-the-nhlbi-initiative-to-study-cellular-and-molecular-mechanisms-of-arterial-stiffness-and-its-association-with-hypertension
#12
Young S Oh, Dan E Berkowitz, Richard A Cohen, C Alberto Figueroa, David G Harrison, Jay D Humphrey, Douglas F Larson, Jane A Leopold, Robert P Mecham, Nelson Ruiz-Opazo, Lakshmi Santhanam, Francesca Seta, John Y J Shyy, Zhongjie Sun, Philip S Tsao, Jessica E Wagenseil, Zorina S Galis
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29122572/characterization-of-vessel-deformations-during-evar-a-preliminary-retrospective-analysis-to-improve-fidelity-of-endovascular-simulators
#13
Laura Cercenelli, Barbara Bortolani, Guido Tiberi, Chiara Mascoli, Ivan Corazza, Mauro Gargiulo, Emanuela Marcelli
OBJECTIVE: During endovascular aneurysm repair (EVAR), vessel deformations occur due to the insertion of tools and deployment of stent grafts in the arteries. We present a method for the characterization of vessel deformations during EVAR, and its application on patient datasets for a preliminary retrospective analysis that may be used to improve fidelity of endovascular simulators. DESIGN: The method provides the extraction of vessel profiles from intraoperative fluoroscopic images and the calculation of a tortuosity index in the 2D fluoroscopy view (τ2D) used to quantify the vessel deformations (δ%) during EVAR caused by the stiff guidewire insertion (δ%Stiff) and the stent graft deployment (δ%Graft), when compared with the undeformed vessel configuration (no device inserted)...
November 6, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29121871/predictive-abilities-of-cardiovascular-biomarkers-to-rapid-decline-of-renal-function-in-chinese-community-dwelling-population-a-5-year-prospective-analysis
#14
Shihui Fu, Chunling Liu, Leiming Luo, Ping Ye
BACKGROUND: Predictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m(2), and long-term prospective study is an optimal choice to explore this problem. Aim of this analysis was to observe this problem during the follow-up of 5 years. METHODS: In a large medical check-up program in Beijing, there were 948 participants with renal function evaluated at baseline and follow-up of 5 years...
November 9, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29120994/inhaled-corticosteroids-in-asthma-promoting-or-protecting-against-atherosclerosis
#15
Michał Podgórski, Maciej Kupczyk, Piotr Grzelak, Małgorzata Bocheńska-Marciniak, Michał Polguj, Piotr Kuna, Ludomir Stefańczyk
BACKGROUND Bronchial asthma is an inflammatory disease of the respiratory system. However, it may also induce systemic effects. Although reports suggest patients with asthma are at increased risk of cardiovascular events, the association between asthma and atherosclerosis is unclear. The aim of the present study was to compare the progression of atherosclerosis between patients with asthma treated with inhaled corticosteroids and healthy controls. MATERIAL AND METHODS In 102 adult patients with asthma, markers of arterial stiffness (pulse wave velocity and augmentation index) were evaluated by applanation tonometry...
November 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29120961/carotid-stiffness-is-significantly-correlated-with-wall-to-lumen-ratio-of-retinal-arterioles
#16
Anna Paini, Maria L Muiesan, Claudia Agabiti-Rosei, Carlo Aggiusti, Carolina De Ciuceis, Fabio Bertacchini, Sarah Duse, Francesco Semeraro, Damiano Rizzoni, Enrico Agabiti-Rosei, Massimo Salvetti
BACKGROUD AND PURPOSE: Wall-to-lumen ratio of retinal arterioles (W/L ratio) might serve as an in-vivo parameter of microvascular damage. No study has investigated the relationship between carotid stiffness and W/L ratio of retinal arteries. Therefore, the aim of the current study was to assess the correlation between local carotid stiffness, as assessed by echotracking technique, and W/L ratio of retinal arterioles, as assessed by noninvasive flowmetry in normotensive patients and in patients with primary hypertension...
November 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29120452/vascular-aging-and-cardiac-maladaptation-in-growth-restricted-preterm-infants
#17
A Sehgal, B J Allison, S M Gwini, S Menahem, S L Miller, G R Polglase
OBJECTIVE: To assess arterial morphology and mechanics in preterm infants with fetal growth restriction (FGR) compared with those appropriate for gestational age (AGA) in the early neonatal period. STUDY DESIGN: This observational study involved 20 preterm FGR infants (28 to 32 weeks) of gestational age (GA) and birth weight (BW) <10th centile and 20 preterm AGA infants. Vascular ultrasound was performed to measure aortic properties. RESULTS: GA and BW of FGR and AGA infants were 29...
November 9, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29119836/the-effects-of-tapering-and-artery-wall-stiffness-on-treatments-for-coarctation-of-the-aorta
#18
Dilan Pathirana, Barbara Johnston, Peter Johnston
Coarctation of the Aorta is a congenital narrowing of the aorta. Two commonly used treatments are resection and end-to-end anastomosis, and stent placements. We simulate blood flow through one-dimensional models of aortas. Different artery stiffnesses, due to treatments, are included in our model, and used to compare blood flow properties in the treated aortas. We expand our previously published model to include the natural tapering of aortas. We look at change in aorta wall radius, blood pressure and blood flow velocity, and find that, of the two treatments, the resection and end-to-end anastomosis treatment more closely matches healthy aortas...
November 9, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29119519/brief-report-physical-activity-body-mass-index-and-arterial-stiffness-in-children-with-autism-spectrum-disorder-preliminary-findings
#19
Kevin S Heffernan, Luis Columna, Natalie Russo, Beth A Myers, Christine E Ashby, Michael L Norris, Tiago V Barreira
We examined the association between physical activity (PA), body mass index (BMI) and novel measures of subclinical cardiovascular disease (CVD) in 15 children with autism spectrum disorder (ASD) (mean age 7 ± 2 years, 2 girls). PA was objectively assessed using accelerometry as time spent in moderate-vigorous physical activity (MVPA). Arterial stiffness was measured via aortic pulse wave velocity (PWV) and taken as a marker of subclinical CVD risk. MVPA was inversely associated with aortic PWV (r = - 0...
November 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29119005/differences-in-left-ventricular-functional-adaptation-to-arterial-stiffness-and-neurohormonal-activation-in-patients-with-hypertension-a-study-with-two-dimensional-layer-specific-speckle-tracking-echocardiography
#20
Darae Kim, Chi Young Shim, Geu-Ru Hong, Sungha Park, InJeong Cho, Hyuk-Jae Chang, Jong-Won Ha, Namsik Chung
Background: Arterial stiffness increases pressure load to the left ventricle (LV), leading to LV hypertrophy and subendocardial ischemia. Neurohormones stimulate myocardial fibrosis and LV dysfunction. We aimed to explore the associations of arterial stiffness and plasma aldosterone with multi-directional, layer-specific LV, and left atrial (LA) mechanical function in hypertensive patients. Methods: Layer-specific LV global longitudinal strain (GLS-trans, GLS-endo, GLS-epi), global circumferential strain (GCS-trans, GCS-endo, GCS-epi), LV torsional parameters, and LA global longitudinal strain (LA GLS) were analyzed by two-dimensional speckle tracking echocardiography in 195 hypertensive patients (110 men, mean age 55 years)...
2017: Clinical Hypertension
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