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Diabetes and Cardiovascular disease

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https://www.readbyqxmd.com/read/29475075/nesfatin-1-and-visfatin-expression-is-associated-with-reduced-atherosclerotic-disease-risk-in-patients-with-rheumatoid-arthritis
#1
Chanel Robinson, Linda Tsang, Ahmed Solomon, Angela J Woodiwiss, Sule Gunter, Mervyn Mer, Hon-Chun Hsu, Monica Gomes, Gavin R Norton, Aletta M E Millen, Patrick H Dessein
Nesfatin is an anti-inflammatory molecule that reduces atherosclerotic cardiovascular risk. By contrast, visfatin has pro-inflammatory properties and is pro-atherogenic. We examined the potential impact of nesfatin and visfatin on atherosclerotic disease in 232 (113 black and 119 white) consecutive rheumatoid arthritis (RA) patients from 2 centers. Independent relationships of nesfatin and visfatin concentrations with metabolic risk factors, endothelial activation, carotid atherosclerosis and altered plaque stability were determined in multivariable regression models...
February 20, 2018: Peptides
https://www.readbyqxmd.com/read/29475022/association-between-depressive-symptoms-and-dietary-intake-in-patients-with-type-1-diabetes
#2
Aila J Ahola, Carol Forsblom, Per-Henrik Groop
AIMS: Depressive mood negatively affects self-care practices, and thereby increases the risk of long-term complications. Not much is known about the association between depressive symptoms and dietary intake in patients with type 1 diabetes, a population with high risk of cardiovascular disease. METHODS: Subjects (n=976, 41% men, age 48±14 years) were participants in the Finnish Diabetic Nephropathy Study. Depressive symptomatology was assessed with the Beck Depression Inventory (BDI)...
February 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29474971/pre-diagnosis-use-of-statins-associates-with-increased-survival-times-of-patients-with-pancreatic-cancer
#3
Tsuyoshi Hamada, Natalia Khalaf, Chen Yuan, Vicente Morales-Oyarvide, Ana Babic, Jonathan A Nowak, Zhi Rong Qian, Kimmie Ng, Douglas A Rubinson, Peter Kraft, Edward L Giovannucci, Meir J Stampfer, Charles S Fuchs, Shuji Ogino, Brian M Wolpin
BACKGROUND & AIMS: Statin medications, most commonly prescribed to reduce lipid levels and prevent cardiovascular disease, may be associated with longer survival times of patients with cancer. However, the association of statins with outcomes of patients with pancreatic adenocarcinoma is not clear. METHODS: We analyzed the association of statin use before a diagnosis of pancreatic cancer with survival times of 648 participants in the Nurses' Health Study and Health Professionals Follow-up Study who were diagnosed with pancreatic adenocarcinoma from 2000 through 2013...
February 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#4
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474816/coffee-for-cardioprotection-and-longevity
#5
REVIEW
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29474499/risk-factors-control-for-primary-prevention-of-cardiovascular-disease-in-men-evidence-from-the-aragon-workers-health-study-awhs
#6
Isabel Aguilar-Palacio, Sara Malo, Cristina Feja, MªJesús Lallana, Montserrat León-Latre, José Antonio Casasnovas, MªJosé Rabanaque, Eliseo Guallar
Benefits of cardiovascular disease (CVD) risk factors control are well known, but goals achievement remains low. The objective of this study is to evaluate the prevalence of CVD risk factors among men ina worker's cohort with no previous CVD, to study control variations across time and the factors associated with poor control. To this end, we conducted a cohort reexamination (2010-2014) within the context of the Aragon Workers Health Study (AWHS). Data from working characteristics, analytical values and pharmacological prescription were included in the analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29474454/the-impact-of-poverty-reduction-and-development-interventions-on-non-communicable-diseases-and-their-behavioural-risk-factors-in-low-and-lower-middle-income-countries-a-systematic-review
#7
Jessie Pullar, Luke Allen, Nick Townsend, Julianne Williams, Charlie Foster, Nia Roberts, Mike Rayner, Bente Mikkelsen, Francesco Branca, Kremlin Wickramasinghe
INTRODUCTION: Non-communicable diseases (NCDs) disproportionately affect low- and lower-middle income countries (LLMICs) where 80% of global NCD related deaths occur. LLMICs are the primary focus of interventions to address development and poverty indicators. We aimed to synthesise the evidence of these interventions' impact on the four primary NCDs (cardiovascular disease, diabetes, chronic respiratory disease and cancer) and their common behavioural risk factors (unhealthy diets, physical inactivity, tobacco and alcohol use)...
2018: PloS One
https://www.readbyqxmd.com/read/29474174/the-economic-costs-of-cardiovascular-disease-diabetes-mellitus-and-associated-complications-in-south-asia-a-systematic-review
#8
REVIEW
Ian F Walker, Fredrike Garbe, Judy Wright, Ian Newell, Naveen Athiraman, Nida Khan, Helen Elsey
BACKGROUND: More than 80% of global deaths caused by cardiovascular disease (CVD) and diabetes mellitus (DM) occur in developing countries. The burden of noncommunicable disease in South Asia is increasing rapidly. OBJECTIVES: To estimate the costs of CVD and the costs of DM to individuals and society in Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka. METHODS: We systematically searched six health and economic databases for studies identifying costs related to CVD or DM and their respective complications...
July 3, 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29473870/prevalence-and-gender-specific-influencing-factors-of-hypertension-among-chinese-adults-a-cross-sectional-survey-study-in-nanchang-china
#9
Hui Zhou, Kai Wang, Xiaojun Zhou, Shiying Ruan, Shaohui Gan, Siyuan Cheng, Yuanan Lu
Hypertension has become the leading cause of death worldwide; data on hypertension among Nanchang adults are sparse. The aim of this study was to investigate the prevalence and gender-specific influencing factors of hypertension in adults in Nanchang, China. A cross-sectional survey was conducted with a representative sample of 2722 Chinese residents aged 18 years and above between May and September 2016, with a response rate of 92.4% (2516/2722). A stratified cluster sampling method was adopted in this study...
February 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29473517/the-prevalence-of-dyslipidemia-and-other-cardiovascular-risk-factors-in-youth-with-diabetes
#10
Don P Wilson, Luke Hamilton, Jose Gonzalez
BACKGROUND: Individuals diagnosed with diabetes mellitus have an increased risk of cardiovascular disease, often leading to morbidity and premature mortality. As the number of youth developing T1D and T2D continues to grow, this early onset predisposes patients to a longer burden of disease and earlier onset of cardiovascular complications. Early identification and effective management and treatment of these risk factors can lead to decreased cardiovascular events and improved quality of life...
February 21, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29473384/five-year-prospective-study-on-cardiovascular-events-in-patients-with-erectile-dysfunction-and-hypotestosterone
#11
Rosanna Iacona, Vito Bonomo, Mariaconcetta Di Piazza, Angela Sansone, Manuela Usala, Salvatore Novo, Carlo Pavone
OBJECTIVE: Testosterone levels play a role in cardiac and vascular pathology. In the present study we investigated the prognostic significance of this hormone for cardiovascular outcome, in a 5-year follow-up. MATERIALS AND METHODS: Our cohort included 802 adult subjects, from 40 to 80 years. Patients were excluded if they had a past history of peripheral or coronary artery disease, and revascularization. A blood sample was drawn to valuate testosterone level, and we considered normal testosterone levels 300 ng/dl...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473119/impact-of-age-at-diagnosis-and-duration-of-type-2-diabetes-on-mortality-in-australia-1997-2011
#12
Lili Huo, Dianna J Magliano, Fanny Rancière, Jessica L Harding, Natalie Nanayakkara, Jonathan E Shaw, Bendix Carstensen
AIMS/HYPOTHESIS: Current evidence suggests that type 2 diabetes may have a greater impact on those with earlier diagnosis (longer duration of disease), but data are limited. We examined the effect of age at diagnosis of type 2 diabetes on the risk of all-cause and cause-specific mortality over 15 years. METHODS: The data of 743,709 Australians with type 2 diabetes who were registered on the National Diabetes Services Scheme (NDSS) between 1997 and 2011 were examined...
February 22, 2018: Diabetologia
https://www.readbyqxmd.com/read/29473098/ischemic-heart-disease-and-ankylosing-spondylitis-assessing-the-role-of-inflammation
#13
Michal Vinker Shuster, Omer Gendelman, Shmuel Tiosano, Doron Comaneshter, Arnon D Cohen, Howard Amital
To assess the association of ankylosing spondylitis (AS) and ischemic heart disease (IHD) compared to traditional cardiovascular (CV) risk factors. Primary care and hospital records of patients with AS were analyzed, using the largest health maintenance organization in Israel, the "Clalit" Health Services data. These patients were compared with age- and gender-matched controls regarding the proportion of IHD in a cross-sectional study. Parameters including socioeconomic status, body mass index (BMI), smoking habits, and coexistent medical conditions hypertension, hyperlipidemia, and diabetes mellitus (DM) - as well as the use of NSAIDs and anti-TNFs were also assessed...
February 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29473039/surfactant-protein-d-in-respiratory-and-non-respiratory-diseases
#14
REVIEW
Grith L Sorensen
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts antimicrobial effects and dampens inflammation through direct microbial interactions and modulation of host cell responses via a series of cellular receptors. However, low protein concentrations, genetic variation, biochemical modification, and proteolytic breakdown can induce decomposition of multimeric SP-D into low-molecular weight forms, which may induce pro-inflammatory SP-D signaling...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29472266/long-term-mortality-in-outpatients-with-type-2-diabetes-in-a-reference-hospital-in-cameroon-a-retrospective-cohort-study
#15
Joyce B Foryoung, Chobufo Ditah, Peter Nde Fon, Yannick Mboue-Djieka, Daniel N Nebongo, Noel D Mbango, Vanessa Balla, Simeon-Pierre Choukem
OBJECTIVES: There are limited data on mortality in patients with type 2 diabetes mellitus (T2DM) in Sub-Saharan Africa. We aimed at determining the mortality rate, and the causes and the predictors of death in patients with T2DM followed as outpatients in a reference hospital in Cameroon. DESIGN: Retrospective cohort study. SETTING: A reference hospital in Cameroon. PARTICIPANTS: From December 2015 to March 2016, patients with T2DM aged 18 years and older and who consulted between January 2009 and December 2014, were contacted directly or through their next of kin, and included in this study...
February 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29472231/carotid-artery-remodeling-is-segment-specific-an-in-vivo-study-by-vessel-wall-magnetic-resonance-imaging
#16
Hiroko Watase, Jie Sun, Daniel S Hippe, Niranjan Balu, Feiyu Li, Xihai Zhao, Venkatesh Mani, Zahi A Fayad, Valentin Fuster, Thomas S Hatsukami, Chun Yuan
OBJECTIVE: Early atherosclerosis is often undetected due in part to compensatory enlargement of the outer wall, termed positive remodeling. Variations in hemodynamic conditions and clinical factors influence the patterns of remodeling. The carotid artery provides an opportunity to examine these variations because of the unique geometry of the carotid bulb. This study aimed to determine differences in remodeling of the common, internal, and bifurcation segments of the carotid using magnetic resonance imaging...
February 22, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29472009/long-term-change-in-cardiorespiratory-fitness-in-relation-to-atrial-fibrillation-and-heart-failure-from-the-kuopio-ischemic-heart-disease-risk-factor-study
#17
Hassan Khan, Setor K Kunutsor, Rainer Rauramaa, Faisal M Merchant, Jari A Laukkanen
The benefits of aerobic fitness in relation to all-cause and cardiovascular mortality is well established; however, the associations of long-term change in cardiorespiratory fitness (CRF) with incident heart failure (HF) and atrial fibrillation (AF) have not been studied before. The Kuopio Ischaemic Heart Disease Risk Factor Study is a prospective cohort comprising men aged 42 to 60 years from the city of Kuopio and its surroundings, with a baseline examination between 1984 and 1989 (V1), a re-examination at 11 years (V2), and up to 15 years of follow-up from V2...
February 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29471918/pathophysiology-and-prevention-of-heart-disease-in-diabetes-mellitus
#18
Ahmet Afşin Oktay, Halis Kaan Akturk, Kerim Esenboğa, Fahad Javed, Nichole M Polin, Eiman Jahangir
Diabetes mellitus (DM) has become a public health problem worldwide, and it has large implications for cardiovascular disease (CVD). In this article, we discuss the etiology and pathophysiology of CVD in DM including the effects of abnormal glucose homeostasis, genetic factors, epigenetics, apoptosis, common pathophysiological mechanisms shared by both DM and CVD, and contributions of other comorbidities. We then cover the pathogenesis of both atherosclerotic disease and cardiomyopathy in relation to DM. Finally, we discuss the prevention of heart disease in DM with a focus on hypertension and dyslipidemia management, weight loss, lifestyle changes, antiplatelet therapy, and glycemic control...
March 2018: Current Problems in Cardiology
https://www.readbyqxmd.com/read/29471856/quantitative-cardiovascular-magnetic-resonance-perfusion-imaging-identifies-reduced-flow-reserve-in-microvascular-coronary-artery-disease
#19
Benjamin Zorach, Peter W Shaw, Jamieson Bourque, Sujith Kuruvilla, Pelbreton C Balfour, Yang Yang, Roshin Mathew, Jonathan Pan, Jorge A Gonzalez, Angela M Taylor, Craig H Meyer, Frederick H Epstein, Christopher M Kramer, Michael Salerno
BACKGROUND: Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial perfusion reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether fully quantitative CMR identifies reduced MPR in this population, and to investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), and perfusion...
February 22, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29471811/ethnic-differences-in-infectious-burden-and-the-association-with-metabolic-risk-factors-for-cardiovascular-disease-a-cross-sectional-analysis
#20
Lara Hartog, Martijn S van Rooijen, Joanne Ujčič-Voortman, Maria Prins, Irene G M van Valkengoed
BACKGROUND: The burden of metabolic risk factors for cardiovascular disease (CVD), such as type 2 diabetes, elevated cholesterol and hypertension, is unequally distributed across ethnic groups. Recent findings suggest an association of infectious burden (IB) and metabolic risk factors, but data from ethnic groups are scarce. Therefore, we investigated ethnic differences in IB and its association with metabolic risk factors. METHODS: We included 440 Dutch, 320 Turkish and 272 Moroccan participants, 18-70 years, of the 2004 general health survey in Amsterdam, the Netherlands...
February 22, 2018: BMC Public Health
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