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https://www.readbyqxmd.com/read/28325493/determining-the-epidemiologic-outcome-and-prognostic-factors-of-oral-malignant-melanoma-by-using-the-surveillance-epidemiology-and-end-results-database
#1
Robert J Lee, Serena A Lee, Thomas Lin, Kevin K Lee, Russell E Christensen
BACKGROUND: The authors conducted a retrospective analysis to determine the epidemiologic, outcome, and prognostic factors in patients with oral malignant melanoma (OMM). METHODS: The authors used the US National Cancer Institute's Surveillance, Epidemiology, and End Results database to analyze patients with OMM from 1973 to 2012. Study variables included age, sex, race, decade of diagnosis, extent of disease, tumor size, treatment modality, and socioeconomic status (SES)...
March 18, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28221789/raman-spectroscopy-reveals-selective-interactions-of-cytochrome-c-with-cardiolipin-that-correlate-with-membrane-permeability
#2
Jay P Kitt, David A Bryce, Shelley D Minteer, Joel M Harris
Permeabilization of the outer mitochondrial membrane is an integral step in apoptosis. The resulting release of pro-apoptotic signaling proteins leads to cell destruction through activation of the cysteine-aspartic protease (caspase) cascade. However, the mechanism of outer mitochondrial membrane (OMM) permeabilization remains unclear. It was recently shown that cytochrome c can induce pore formation in cardiolipin-containing phospholipid membranes, leading to large dextran and protein permeability. In this work, the interaction of cytochrome c with cardiolipin-containing phospholipid vesicles, serving as models of the OMM, is investigated to probe cytochrome c-induced permeability...
March 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28154412/superresolution-imaging-identifies-that-conventional-trafficking-pathways-are-not-essential-for-endoplasmic-reticulum-to-outer-mitochondrial-membrane-protein-transport
#3
Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K Jaiswal, Anamaris M Colberg-Poley
Most nuclear-encoded mitochondrial proteins traffic from the cytosol to mitochondria. Some of these proteins localize at mitochondria-associated membranes (MAM), where mitochondria are closely apposed with the endoplasmic reticulum (ER). We have previously shown that the human cytomegalovirus signal-anchored protein known as viral mitochondria-localized inhibitor of apoptosis (vMIA) traffics from the ER to mitochondria and clusters at the outer mitochondrial membrane (OMM). Here, we have examined the host pathways by which vMIA traffics from the ER to mitochondria and clusters at the OMM...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28055087/osteopathic-philosophy-and-manipulation-enhancement-program-influence-on-osteopathic-medical-students-interest-in-osteopathic-manipulative-medicine
#4
Mikhail Volokitin, Pavan V Ganapathiraju
CONTEXT: Interest in osteopathic manipulative medicine (OMM) among first- and second-year osteopathic medical students typically declines toward the end of the second year of medical school. An osteopathic philosophy and manipulation enhancement (OPME) program was implemented for osteopathic medical students to gain additional exposure to OMM at the Touro College of Osteopathic Medicine in New York, New York. OBJECTIVE: To assess how additional exposure to OMM through the OPME program influenced first- and second-year students' interest in using OMM...
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28042535/effects-of-mono-2-ethylhexyl-phthalate-and-di-2-ethylhexyl-phthalate-administrations-on-oocyte-meiotic-maturation-apoptosis-and-gene-quantification-in-mouse-model
#5
Forouzan Absalan, Sadegh Saremy, Esrafil Mansori, Mahin Taheri Moghadam, Ali Reza Eftekhari Moghadam, Razie Ghanavati
OBJECTIVE: Phthalates, which are commonly used to render plastics into soft and flexible materials, have also been determined as developmental and reproductive toxicants in human and animals. The purpose of this study was to evaluate the effect of mono-(2- ethylhexyl) phthalate (MEHP) and di-(2-ethylhexyl) phthalate (DEHP) oral administrations on maturation of mouse oocytes, apoptosis and gene transcription levels. MATERIALS AND METHODS: In this experimental study, immature oocytes recovered from Naval Medical Research Institute (NMRI) mouse strain (6-8 weeks), were divided into seven different experimental and control groups...
2017: Cell Journal
https://www.readbyqxmd.com/read/28028129/long-term-outcomes-after-carbon-ion-radiotherapy-for-oral-mucosal-malignant-melanoma
#6
Kensuke Naganawa, Masashi Koto, Ryo Takagi, Azusa Hasegawa, Hiroaki Ikawa, Kazuo Shimozato, Tadashi Kamada, Yoshitaka Okamoto
Oral mucosal malignant melanoma (OMM) is extremely rare and has a poor prognosis. Owing to its rarity, it has not yet been possible to establish an optimal treatment modality. The objective of this study was to evaluate the long-term efficacy of carbon-ion radiotherapy (C-ion RT) for OMM. Between 1997 and 2013, 19 patients with OMM were treated with C-ion RT alone. Patient ages ranged from 44 to 84 years (median, 69 years). Nine men and 10 women were included. OMMs were restaged in accordance with the seventh edition of the tumour/node/metastasis (TNM) Staging System of the International Union Against Cancer...
December 26, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27989758/low-level-of-mono-2-ethylhexyl-phthalate-reduces-oocyte-developmental-competence-in-association-with-impaired-gene-expression
#7
D Kalo, Z Roth
Di-(2-ethylhexyl) phthalate (DEHP) and its metabolite, mono-(2-ethylhexyl) phthalate (MEHP), are reproductive toxicants. However, disruptive effects of MEHP at low concentrations on the oocyte and developing blastocyst are unknown. Previously, we detected low levels of MEHP in follicular fluid aspirated from DEHP-treated cows associated with reduced estradiol levels. Moreover, the MEHP concentrations found were similar to those reported for follicular fluid aspirated from women who have undergone IVF cycles...
December 15, 2016: Toxicology
https://www.readbyqxmd.com/read/27960556/acetaminophen-toxicity-in-rat-and-mouse-hepatocytes-in-vitro
#8
Otto Kučera, René Endlicher, David Rychtrmoc, Halka Lotková, Ondřej Sobotka, Zuzana Červinková
CONTEXT: Acetaminophen (APAP) hepatotoxicity is often studied in primary cultures of hepatocytes of various species, but there are only few works comparing interspecies differences in susceptibility of hepatocytes to APAP in vitro. OBJECTIVES: The aim of our work was to compare hepatotoxicity of APAP in rat and mouse hepatocytes in primary cultures. MATERIALS AND METHODS: Hepatocytes isolated from male Wistar rats and C57Bl/6J mice were exposed to APAP for up to 24 h...
December 14, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27932492/novel-regulatory-roles-of-mff-and-drp1-in-e3-ubiquitin-ligase-march5-dependent-degradation-of-mid49-and-mcl1-and-control-of-mitochondrial-dynamics
#9
Edward Cherok, Shan Xu, Sunan Li, Shweta Das, W Alex Meltzer, Michal Zalzman, Chunxin Wang, Mariusz Karbowski
MARCH5, an OMM-associated E3 ubiquitin ligase, controls mitochondrial function. Despite its importance, the mechanism and factors controlling MARCH5 activity are largely unknown. Here we report that the MARCH5 C-terminal domain plays a critical role in degradation of MARCH5 substrates, likely by facilitating release of ubiquitinated proteins from the OMM. We also found that the mitochondrial fission proteins Drp1 and Mff negatively regulate MARCH5's activity toward MiD49 and Mcl1. Knockouts of either Drp1 or Mff led to reduced expression, shorter half-lives, and increased ubiquitination of MiD49 and Mcl1...
December 8, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27913278/molecular-basis-for-the-dual-subcellular-distribution-of-microsomal-glutathione-transferase-1
#10
Miyuki Shimoji, Ricardo A Figueroa, Etienne Neve, Danuta Maksel, Gabriela Imreh, Ralf Morgenstern, Einar Hallberg
Microsomal glutathione transferase 1 (MGST1) is a membrane bound enzyme involved in the detoxification of reactive electrophiles and protection of membranes from oxidative stress. The enzyme displays an unusual and broad subcellular distribution with especially high levels in the endoplasmic reticulum (ER) and outer mitochondrial membrane (OMM). Here we examined the molecular basis for this dual distribution. We hypothesized that the amphipathic properties of the first transmembrane segment (TMS), that contains a positively charged lysine (K25), is a central feature guiding dual targeting...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27913212/vcp-cooperates-with-ubxd1-to-degrade-mitochondrial-outer-membrane-protein-mcl1-in-model-of-huntington-s-disease
#11
Xing Guo, Xin Qi
Proteasome-dependent turnover of mitochondrial outer membrane (OMM)-associated proteins is one of the mechanisms for maintaining proper mitochondrial quality and function. However, the underlying pathways and their implications in human disease are poorly understood. Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder caused by expanded CAG repeats in the N terminal of the huntingtin gene (mutant Huntingtin, mtHtt). In this study, we show an extensive degradation of the OMM protein MCL1 (Myeloid cell leukemia sequence 1) in both HD mouse striatal cells and HD patient fibroblasts...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27893142/assessment-of-hospital-staff-s-knowledge-of-osteopathic-manipulative-medicine-a-survey-based-study
#12
Jessica B Smith-Kelly, Andres Cardenas
CONTEXT: Research has shown that osteopathic manipulative treatment (OMT) in hospitalized patients can shorten hospital length of stay. However, hospital staff may be unfamiliar with OMT and its use in this setting. OBJECTIVE: To assess a hospital staff's knowledge of osteopathic manipulative medicine (OMM) and investigate whether there is a correlation between job category and knowledge of OMM. METHODS: The study used a 13-item survey that was developed using SurveyMonkey...
December 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27814309/osteopathic-manipulation-as%C3%A2-a%C3%A2-complementary-approach-to%C3%A2-parkinson-s%C3%A2-disease-a%C3%A2-controlled-pilot%C3%A2-study
#13
Joanne DiFrancisco-Donoghue, Theresa Apoznanski, Kristen de Vries, Min-Kyung Jung, Jayme Mancini, Sheldon Yao
BACKGROUND: Osteopathic Manipulative Medicine (OMM) is a therapy of manual forces that is directed to improve function and homeostasis. It has been shown to improve balance in individuals with dizziness, and improve gait in Parkinson's disease (PD). This study was designed to determine if our pre-defined OMM protocol would improve motor function and balance in individuals with PD. METHODS: A randomized controlled trial to test OMM on balance and motor function in PD measured by the Mini-BESTest, Sensory Organization Test (SOT), and MDS-UPDRS...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/27806990/influence-of-own-mother-s-milk-on-bronchopulmonary-dysplasia-and-costs
#14
Aloka L Patel, Tricia J Johnson, Beverley Robin, Harold R Bigger, Ashley Buchanan, Elizabeth Christian, Vikram Nandhan, Anita Shroff, Michael Schoeny, Janet L Engstrom, Paula P Meier
BACKGROUND: Human milk from the infant's mother (own mother's milk; OMM) feedings reduces the risk of several morbidities in very low birthweight (VLBW) infants, but limited data exist regarding its impact on bronchopulmonary dysplasia (BPD). OBJECTIVE: To prospectively study the impact of OMM received in the neonatal intensive care unit (NICU) on the risk of BPD and associated costs. DESIGN/METHODS: A 5-year prospective cohort study of the impact of OMM dose on growth, morbidity and NICU costs in VLBW infants...
November 2, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27763642/bcl-2-proteins-bid-and-bax-form-a-network-to-permeabilize-the-mitochondria-at-the-onset-of-apoptosis
#15
Robert F Gahl, Pallavi Dwivedi, Nico Tjandra
The most critical step in the initiation of apoptosis is the activation of the Bcl-2 family of proteins to oligomerize and permeabilize the outer-mitochondrial membrane (OMM). As this step results in the irreversible release of factors that enhance cellular degradation, it is the point of no return in programmed cell death and would be an ideal therapeutic target. However, the arrangement of the Bcl-2 proteins in the OMM during permeabilization still remains unknown. It is also unclear whether the Bcl-2 protein, Bid, directly participates in the formation of the oligomers in live cells, even though it is cleaved and translocates to the OMM at the initiation of apoptosis...
October 20, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27697863/endoplasmic-reticulum-stress-enhances-mitochondrial-metabolic-activity-in-mammalian-adrenals-and-gonads
#16
Manoj Prasad, Anna N Walker, Jasmeet Kaur, James L Thomas, Shirley A Powell, Amit V Pandey, Randy M Whittal, William E Burak, Guy Petruzzelli, Himangshu S Bose
The acute response to stress consists of a series of physiological programs to promote survival by generating glucocorticoids and activating stress response genes that increase the synthesis of many chaperone proteins specific to individual organelles. In the endoplasmic reticulum (ER), short-term stress triggers activation of the unfolded protein response (UPR) module that either leads to neutralization of the initial stress or adaptation to it; chronic stress favors cell death. UPR induces expression of the transcription factor, C/EBP homology protein (CHOP), and its deletion protects against the lethal consequences of prolonged UPR...
December 15, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27660309/the-role-of-drp1-adaptor-proteins-mid49-and-mid51%C3%A2-in-mitochondrial-fission-implications-for-human-disease
#17
REVIEW
Kathleen Atkins, Asish Dasgupta, Kuang-Hueih Chen, Jeff Mewburn, Stephen L Archer
Mitochondrial morphology is governed by the balance of mitochondrial fusion, mediated by mitofusins and optic atrophy 1 (OPA1), and fission, mediated by dynamin-related protein 1 (Drp1). Disordered mitochondrial dynamics alters metabolism, proliferation, apoptosis and mitophagy, contributing to human diseases, including neurodegenerative syndromes, pulmonary arterial hypertension (PAH), cancer and ischemia/reperfusion injury. Post-translational regulation of Drp1 (by phosphorylation and SUMOylation) is an established means of modulating Drp1 activation and translocation to the outer mitochondrial membrane (OMM)...
November 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27637331/strategic-positioning-and-biased-activity-of-the-mitochondrial-calcium-uniporter-in-cardiac-muscle
#18
Sergio De La Fuente, Celia Fernandez-Sanz, Caitlin Vail, Elorm J Agra, Kira Holmstrom, Junhui Sun, Jyotsna Mishra, Dewight Williams, Toren Finkel, Elizabeth Murphy, Suresh K Joseph, Shey-Shing Sheu, György Csordás
Control of myocardial energetics by Ca(2+) signal propagation to the mitochondrial matrix includes local Ca(2+) delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial membrane (IMM) Ca(2+) uniporter (mtCU). mtCU activity in cardiac mitochondria is relatively low, whereas the IMM surface is large, due to extensive cristae folding. Hence, stochastically distributed mtCU may not suffice to support local Ca(2+) transfer. We hypothesized that mtCU concentrated at mitochondria-SR associations would promote the effective Ca(2+) transfer...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27597980/the-relationship-of-metabolic-syndrome-traits-with-beta-cell-function-and-insulin-sensitivity-by-oral-minimal-model-assessment-in-south-asian-and-european-families-residing-in-the-netherlands
#19
Thekla Geragotou, Sjaam Jainandunsing, Behiye Özcan, Felix W M de Rooij, Alexander Kokkinos, Nicholas Tentolouris, Eric J G Sijbrands
Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity index (ISI), static, dynamic, and total beta-cell responsivity indices (Φ), and disposition indices (DIs) were calculated with the use of oral minimal model (OMM). Results. In both ethnicities, ISI was lower in the subgroup with MetS and T2D as compared to the subgroup without MetS nor T2D (P < 0...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27531991/regulation-of-star-by-the-n-terminal-domain-and-coinduction-of-sik1-and-tis11b-znf36l1-in-single-cells
#20
Jinwoo Lee, Tiegang Tong, Haichuan Duan, Yee Hoon Foong, Ibrahim Musaitif, Takeshi Yamazaki, Colin Jefcoate
The cholesterol transfer function of steroidogenic acute regulatory protein (StAR) is uniquely integrated into adrenal cells, with mRNA translation and protein kinase A (PKA) phosphorylation occurring at the mitochondrial outer membrane (OMM). The StAR C-terminal cholesterol-binding domain (CBD) initiates mitochondrial intermembrane contacts to rapidly direct cholesterol to Cyp11a1 in the inner membrane (IMM). The conserved StAR N-terminal regulatory domain (NTD) includes a leader sequence targeting the CBD to OMM complexes that initiate cholesterol transfer...
2016: Frontiers in Endocrinology
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