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https://www.readbyqxmd.com/read/29470772/robotics-confers-an-advantage-in-right-hemicolectomy-with-intracorporeal-anastomosis-when-matched-against-conventional-laparoscopy
#1
James Chi-Yong Ngu, Yvonne Ying-Ru Ng
Comparisons between robotic and laparoscopic right hemicolectomy have been confounded by variations in operative technique. This study evaluates the two procedures after standardizing the intraoperative steps and perioperative management. Patients who underwent robotic right hemicolectomy with intracorporeal bowel anastomosis between July 2015 and June 2017 were matched with a laparoscopic group. Perioperative management was in accordance to an enhanced recovery protocol. Outcomes and histopathological data were compared...
February 22, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29468162/short-term-oral-antibiotics-treatment-promotes-inflammatory-activation-of-colonic-invariant-natural-killer-t-and-conventional-cd4-t-cells
#2
Claudia Burrello, Federica Garavaglia, Fulvia Milena Cribiù, Giulia Ercoli, Silvano Bosari, Flavio Caprioli, Federica Facciotti
The gut mucosa is continuously exposed to a vast community of microorganisms, collectively defined as microbiota, establishing a mutualistic relationship with the host and contributing to shape the immune system. Gut microbiota is acquired at birth, and its composition is relatively stable during the entire adult life. Intestinal dysbiosis, defined as a microbial imbalance of gut bacterial communities, can be caused by several factors, including bacterial infections and antibiotic use, and has been associated with an increased risk to develop or exacerbate immune-mediated pathologies, such as allergic reactions, asthma, and inflammatory bowel diseases...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29467549/glucose-transporter-expression-in-the-human-colon
#3
Flavia Merigo, Alessandro Brandolese, Sonia Facchin, Silvia Missaggia, Paolo Bernardi, Federico Boschi, Renata D'Incà, Edoardo Vincenzo Savarino, Andrea Sbarbati, Giacomo Carlo Sturniolo
AIM: To investigate by immunostaining glucose transporter expression in human colorectal mucosa in controls and patients with inflammatory bowel disease (IBD). METHODS: Colorectal samples were obtained from patients undergoing lower endoscopic colonoscopy or recto-sigmoidoscopy. Patients diagnosed with ulcerative colitis ( n = 18) or Crohn's disease ( n = 10) and scheduled for diagnostic colonoscopy were enrolled. Patients who underwent colonoscopy for prevention screening of colorectal cancer or were followed-up after polypectomy or had a history of lower gastrointestinal symptoms were designated as the control group (CTRL, n = 16)...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29462379/a-cross-talk-between-microbiota-derived-short-chain-fatty-acids-and-the-host-mucosal-immune-system-regulates-intestinal-homeostasis-and-inflammatory-bowel-disease
#4
Pedro Gonçalves, João Ricardo Araújo, James P Di Santo
Gut microbiota has a fundamental role in the energy homeostasis of the host and is essential for proper "education" of the immune system. Intestinal microbial communities are able to ferment dietary fiber releasing short-chain fatty acids (SCFAs). The SCFAs, particularly butyrate (BT), regulate innate and adaptive immune cell generation, trafficing, and function. For example, BT has an anti-inflammatory effect by inhibiting the recruitment and proinflammatory activity of neutrophils, macrophages, dendritic cells, and effector T cells and by increasing the number and activity of regulatory T cells...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29460920/long-term-safety-of-in-utero-exposure-to-anti-tnf%C3%AE-drugs-for-the-treatment-of-inflammatory-bowel-disease-results-from-the-multicenter-european-teddy-study
#5
M Chaparro, A Verreth, T Lobaton, E Gravito-Soares, M Julsgaard, E Savarino, F Magro, I Avni Biron, P Lopez-Serrano, M J Casanova, M Gompertz, S Vitor, M Arroyo, D Pugliese, Y Zabana, R Vicente, M Aguas, A Bar-Gil Shitrit, A Gutierrez, G A Doherty, L Fernandez-Salazar, J Martínez Cadilla, J M Huguet, A O'Toole, E Stasi, N Manceñido Marcos, A Villoria, K Karmiris, J F Rahier, C Rodriguez, M Diz-Lois Palomares, G Fiorino, J M Benitez, M Principi, T Naftali, C Taxonera, G Mantzaris, L Sebkova, B Iade, D Lissner, I Ferrer Bradley, A Lopez-San Roman, I Marin-Jimenez, O Merino, M Sierra, M Van Domselaar, F Caprioli, I Guerra, P Peixe, M Piqueras, I Rodriguez-Lago, Y Ber, K van Hoeve, P Torres, M Gravito-Soares, D Rudbeck-Resdal, O Bartolo, A Peixoto, G Martin, A Armuzzi, A Garre, M G Donday, F J Martín de Carpi, J P Gisbert
OBJECTIVES: The long-term safety of exposure to anti-tumor necrosis factor (anti-TNFα) drugs during pregnancy has received little attention. We aimed to compare the relative risk of severe infections in children of mothers with inflammatory bowel disease (IBD) who were exposed to anti-TNFα drugs in utero with that of children who were not exposed to the drugs. METHODS: Retrospective multicenter cohort study. Exposed cohort: children from mothers with IBD receiving anti-TNFα medication (with or without thiopurines) at any time during pregnancy or during the 3 months before conception...
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29460802/can-quantab-titrator-sticks-reliably-predict-urinary-sodium
#6
Fergus W Hamilton, Chris M Penfold, Andrew R Ness, Kirsty P Stevenson, Charlotte Atkinson, Andrew M Day, Gregory M Sebepos-Rogers, Jonathan Tyrrell-Price
BACKGROUND & AIMS: Urinary sodium concentration is a commonly used marker for extracellular fluid depletion which is often associated with dehydration. A point of care test for urinary sodium may reduce delays in clinical decision making by offering more timely guidance leading to improved salt and fluid management. We compared laboratory assessed urinary sodium with a potential point of care measure of urinary chloride in a variety of in- and outpatient specialities, to explore its use as an indicator of low urine sodium...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460659/video-assisted-patient-education-improves-compliance-with-follow-up-and-depression-scores-in-inflammatory-bowel-diseases
#7
Nagesh Kamat, Surulivel Rajan Mallayasamy, P S V N Sharma, Asha Kamath, C Ganesh Pai
OBJECTIVES: Patients with inflammatory bowel diseases (IBD) have to deal with a poor quality of life (QOL) and psychomorbidity resulting from an incurable illness. We aimed to study the effect of patient education on QOL, compliance, anxiety and depression in IBD. METHODS: Patients were prospectively enrolled over two years beginning July 2014 and divided into an interventional and usual care group. Both received the standard of care, but the former in addition received an 8 minute session of video-assisted education...
February 20, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29459005/three-extreme-cases-of-short-bowel-syndrome-step-and-neovalves-decision-algorithm
#8
Antonio Alastrué, Pau Moreno, Jordi Tarascó, Sandra Vela, Eva Martínez
No abstract text is available yet for this article.
February 16, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29452701/corrigendum-to-inhibition-of-fgf-signaling-in-short-bowel-syndrome-increases-weight-loss-and-epithelial-proliferation-surgery-volume-161-number-3-2017-694-703
#9
Kathy A Schall, Kathleen A Holoyda, Mubina Isani, Ching-Ling Lien, Denise Al Alam, Tracy C Grikscheit
No abstract text is available yet for this article.
February 13, 2018: Surgery
https://www.readbyqxmd.com/read/29441452/long-term-follow-up-of-the-effects-of-fecal-microbiota-transplantation-in-combination-with-soluble-dietary-fiber-as-a-therapeutic-regimen-in-slow-transit-constipation
#10
Xueying Zhang, Hongliang Tian, Lili Gu, Yongzhan Nie, Chao Ding, Xiaolong Ge, Bo Yang, Jianfeng Gong, Ning Li
As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation (FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation (STC), we conducted a single-center, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber (pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber (pectin) daily during the follow-up...
February 6, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29439318/the-effect-of-three-different-surgical-techniques-for-colon-anastomosis-on-regional-postoperative-microperfusion-laser-doppler-flowmetry-study-in-pigs
#11
Milan Kaska, Slavomir Blazej, Zdenek Turek, Ales Ryska, Boris Jegorov, Vera Radochova, Jan Bezouska, Jiri Paral
BACKGROUND: The optimal surgical approach to reconnecting bowel ends safely after resection is of great importance. OBJECTIVES: This project is focused on assessment of the perianastomotic microcirculation quality in the short postoperative period when using three different anastomosis techniques in experimental animal. METHODS: The experimental study involved 27 young female domestic pigs divided into three subgroups of 9 animals according to each surgical method of anastomosis construction in the sigmoid colon region: by manual suture, by stapler, or by gluing...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29434841/sodium-butyrate-induces-senescence-and-inhibits-the-invasiveness-of-glioblastoma-cells
#12
Hidemitsu Nakagawa, Satoru Sasagawa, Kazuyuki Itoh
Sodium butyrate (SB), a short chain (C-4) saturated fatty acid, is present in the human bowel at increased concentrations (~2 mM) as a food metabolite. It has been demonstrated that SB exerts an anti-tumor effect as a histone deacetylase inhibitor; however, its precise mechanism of action remains to be elucidated. The present study focused on the mechanisms underlying the effects of SB on glioblastoma (GB) cell proliferation, motility and invasion. In human GB A172 cells, flow cytometry and a Boyden chamber assay demonstrated that physiological concentrations of SB (0...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432213/regulation-of-intestinal-lipid-and-lipoprotein-metabolism-by-the-proglucagon-derived-peptides-glucagon-like-peptide-1-and-glucagon-like-peptide-2
#13
Erin E Mulvihill
PURPOSE OF REVIEW: The intestine is highly efficient at absorbing and packaging dietary lipids onto the structural protein apoB48 for distribution throughout the body. Here, we summarize recent advances into understanding the physiological and pharmacological actions of the proglucagon-derived peptides: glucagon like peptide 1 (GLP-1) and glucagon like peptide 2 (GLP-2) on intestinal lipoprotein secretion. RECENT FINDINGS: Several recent studies have elucidated mechanisms underlying the paradoxical effects of GLP-1 and GLP-2 on intestinal production of triglyceride-rich lipoproteins (TRLs)...
February 9, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29423160/stricturoplasty-a-bowel-sparing-option-for-long-segment-small-bowel-crohn-s-disease
#14
Alexandra M Limmer, Hoey C Koh, Andrew Gilmore
Stricturoplasty is a surgical option for management of severe stricturing Crohn's disease of the small bowel. It avoids the need for small bowel resection and the associated metabolic complications. This report contrasts the indications and technical aspects of two different stricturoplasty techniques. Case 1 describes an extensive Michelassi (side-to-side isoperistaltic) stricturoplasty performed for a 100 cm segment of diseased small bowel in a 45-year-old patient. Case 2 describes the performance of 12 Heineke-Mikulicz stricturoplasties in a 23-year-old patient with multiple short fibrotic strictures...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29415840/palliative-home-parenteral-nutrition-clinical-service-evaluation-and-identifying-potential-prognostic-factors-to-assist-with-patient-selection
#15
B Drinkwater, B K Clarke, J Jones, J Ratcliffe, P Deel-Smith, S C Cooper
BACKGROUND AND AIMS: Home parenteral nutrition (HPN) for palliation has little evidence supporting existing guidance. Patient selection remains challenging. We aimed to evaluate use of palliative HPN in our service against ESPEN guidance, and to identify potential prognostic indicators. METHODS: Palliative care patients commenced on HPN were identified. Medical notes, computer records and HPN database were accessed to identify patient demographics, primary diagnosis and aetiology of intestinal failure, blood test results potentially associated with prognosis (eGFR, albumin, CRP, Hb), presence of ascites, and PN duration...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29415499/in-vivo-assessment-of-resistant-starch-degradation-by-the-caecal-microbiota-of-mice-using-rna-based-stable-isotope-probing-a-proof-of-principle-study
#16
Elena Herrmann, Wayne Young, Verena Reichert-Grimm, Severin Weis, Christian U Riedel, Douglas Rosendale, Halina Stoklosinski, Martin Hunt, Markus Egert
Resistant starch (RS) is the digestion resistant fraction of complex polysaccharide starch. By reaching the large bowel, RS can function as a prebiotic carbohydrate, i.e., it can shape the structure and activity of bowel bacterial communities towards a profile that confers health benefits. However, knowledge about the fate of RS in complex intestinal communities and the microbial members involved in its degradation is limited. In this study, 16S ribosomal RNA (rRNA)-based stable isotope probing (RNA-SIP) was used to identify mouse bowel bacteria involved in the assimilation of RS or its derivatives directly in their natural gut habitat...
February 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29413019/nutritional-therapy-in-adult-short-bowel-syndrome-patients-with-chronic-intestinal-failure
#17
REVIEW
Palle Bekker Jeppesen, Kristian Asp Fuglsang
Intestinal failure (IF) is the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that parenteral support (PS) is required to maintain health and/or growth. This article critically revises the gaps in and evidence for providing general nutritional therapy recommendations in the Short Bowel Syndrome-IF population. It addresses the need for an individualized approach, aiming to reduce or even eliminate the need for PS, and emphasizes a need to focus on effects of dietary interventions on the quality of life of these patients...
March 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29409620/necrotizing-enterocolitis-as-a-prognostic-factor-for-the-neurodevelopmental-outcome-of-preterm-infants-match-control-study-after-2years
#18
Antje Allendorf, Ruth Dewitz, Joy Weber, Shahrzad Bakthiar, Rolf Schloesser, Udo Rolle
PURPOSE: Necrotizing enterocolitis (NEC) in very low birth weight infants is a risk factor for developmental delay. To our knowledge, there are no studies published investigating the neurodevelopmental outcome of patients with NEC comparing surgically treated and conservatively treated patients versus match paired controls. The aim of this retrospective case control study was to measure the neurodevelopmental outcome of patients with NEC who were treated surgically or conservatively METHODS: All patients were identified, who have been diagnosed with NEC (ICD-10 code, P77) born between 2006 and 2013...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29405492/effects-of-naloxegol-on-whole-gut-transit-in-opioid-na%C3%A3-ve-healthy-subjects-receiving-codeine-a-randomized-controlled-trial
#19
H Halawi, P Vijayvargiya, I Busciglio, I Oduyebo, D Khemani, M Ryks, D Rhoten, D Burton, L A Szarka, A Acosta, M Camilleri
BACKGROUND: Nausea, vomiting, and constipation (OIC) are common adverse effects of acute or chronic opioid use. Naloxegol (25 mg) is an approved peripherally active mu-opiate opioid receptor antagonist. AIM: To compare the effects on pan-gut transit of treatment with codeine, naloxegol, or combination in healthy volunteers. METHODS: We conducted a randomized, double-blind, placebo-controlled, single-center, parallel-group study in 72 healthy opioid-naïve adults, randomized to: codeine (30 mg q...
February 6, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29405447/nutritional-therapy-complications-in-children-with-ultra-short-bowel-syndrome-include-growth-deficiency-but-not-cholestasis
#20
Katarzyna Olszewska, Janusz Ksiazyk, Dariusz Kozlowski, Magdalena Pajdowska, Malgorzata Janusz, Maciej Jaworski
AIM: Children with ultra-short bowel syndrome (USBS) have not been extensively studied to date because the condition is rare. The aim of the study was to assess the nutritional status of children with USBS receiving home parenteral nutrition, by using citrulline serum concentration and cholestasis. METHODS: We studied 17 patients with USBS, with a median age of 6.6 years and median duration of parenteral nutrition of 6.6 years. The study was carried out at The Children's Memorial Health Institute, Warsaw, from January 2014 to January 2015...
February 6, 2018: Acta Paediatrica
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